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Dissertations / Theses on the topic 'Binding assay'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Kopanchuk, Sergei. "Regulation of ligand binding of melanocortin receptor subtypes /." Online version, 2006. http://dspace.utlib.ee/dspace/bitstream/10062/950/5/kopanchuk.pdf.

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2

Nguyen, Loc Tien. "BIV TAR RNA binding glycine mutant Tat peptides| An integrated modeling and binding assay approach." Thesis, San Jose State University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1602943.

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<p> Interactions between viral encoded regulatory proteins and RNA target sequences control gene expression of Lentiviruses, including human immunodeficiency virus (HIV).  Bovine immunodeficiency virus (BIV) provides a simpler model of interaction between the viral trans-activating protein (Tat) and trans-activation response RNA element (TAR), using Tat peptides binding to TAR RNA fragments. The resulting characterization of the hinge region of native BIV TAR-Tat complex was confirmed by more comprehensive calculations, involving an exhaustive generation of lattice chains. This modeled

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3

Meddins, Anna Kathryn. "Isolating candidate cyclin-binding proteins using the Yeast Two-Hybrid assay." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627268.

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4

Pueblo, Hanna Elizabeth. "APPLICATIONS OF DYNAMIC ISOELECTRIC/ANISOTROPY BINDING LIGAND ASSAY FOR PROTEOMIC RESEARCH." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/494.

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The work presented in this dissertation centers around the development of analytical tools for the study of advanced proteomics. Section 1 of this work reviews the need for high efficiency protein separation techniques. Dynamic isoelectric focusing (DIEF) is new technique similar to capillary isoelectric focusing (CIEF) invented by Dr. Luke Tolley at Southern Illinois University Carbondale. Using DIEF, the electric field inside the separation capillary can be modified using high voltage electrodes, additional to the anode and cathode, to control the depth and shape of the resulting pH gradi

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5

Sudlow, James. "Design, synthesis and high-throughput assay of inhibitors for p97-cofactor binding." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24875.

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p97 is an abundant protein in human cells and is essential for many forms of life. Its putative mechanism of action is the binding of adaptor proteins, which mediate its functions, and subsequent transfer of energy from ATP hydrolysis through the adaptor to substrate proteins. The unfolding or degradation of these substrates is known to regulate a diverse number of processes and the malfunction of p97 in many of these has been linked to a range of diseases. Developing inhibitors for p97-cofactor binding may help uncover further functions, as well as potentially providing a treatment for a numb

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6

Bourns, Brenda. "Development and characterization of a new assay to examine telomere-protein interactions in vivo /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6336.

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7

Engqvist, Martin. "A generic capture assay for immunogenicity, using Biacore." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198767.

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The purpose of this investigation was to create and optimise a capture assay for the detectionof anti-drug antibodies (ADA) in human plasma, using Biacore. We also dealt with the nonspecificplasma binding to mouse-derived anti-biotin which may occur in the capture assay.By paying attention to these things we aimed at reaching as high sensitivity as possible for theADA detection. The capture assay also benefited and gained flexibility from using the same regenerationsolution irrespective of drug and from having a composition that minimises the risk ofdamaging drug epitopes.

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8

Mahatnirunkul, Thanisorn. "One-step gold nanoparticle size-shift assay using synthetic binding proteins and dynamic light scattering." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19216/.

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Gold nanoparticles (AuNPs) have attracted significant interest for biosensing applications because of their distinctive optical properties including light scattering. Dynamic light scattering (DLS) is an analytical tool used routinely for measuring the hydrodynamic size of colloids and nanoparticles in liquid environment. By combining the light scattering properties of AuNPs with DLS, a label-free, facile and sensitive assay has been developed. There have been several reports showing that NPcoupled DLS size shift assays are capable of quantitative analysis for target analytes ranging from meta

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9

Xie, Tian. "Scintillation proximity assay (SPA) measuring p53 DNA binding and total p53 level in human thyroid cancer cell line ARO." Diss., Online access via UMI:, 2007.

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10

Wan, Jonathan. "Development of a Pulse Proteolysis Assay to Investigate Stability in the Measles Polymerase Nucleocapsid Binding Domain." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297801.

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The nucleocapsid-binding domains (NBDs) form part of the paramyxovirus replication complex and mediate attachment to the nucleocapsid, a nucleoprotein complex containing the viral RNA genome. NBDs form a very simple helical bundle, and vary between intrinsically unstructured and highly stable in the case of mumps and measles respectively. Despite the differences in properties, these domains show similar sequence and structure. The differences between mumps and measles NBDs provide a point of comparison to investigate differences in structural stability. Using the measles protein as a starting

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11

Tan, Chik Kaw. "Development of a ligand-receptor binding assay for characterizing AVP receptors in isolated rat kidney tubules." Thesis, Keele University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262383.

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12

Faradj, Lana. "Improving Caco-2 cell permeability assay using phospholipid covered silica beads." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-432865.

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The Caco-2 cell assay is widely used for in vitro permeability measurements. However, a draw back with the assay that this study will focus on improving, is compound adsorption to the plastic material. Lipophilic compounds such as Cyclosporin A and Peptide J, that will be used in this study, tend to bind to the plastic material in the assay. This can result in poor recovery and misleading permeability predictions. Bovine serum albumin (BSA) is an alternative used today to prevent this but is not always successful. The aim of this study is therefore to improve the Caco-2 permeability assay b

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13

Keymanesh, Keykhosrow. "The yeast-one-hybrid assay identifies LHCA2 and HSPRO2 as double-SORLIP1 element binding proteins in Arabidopsis thaliana." Thesis, California State University, Long Beach, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1522636.

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<p> Early light induced proteins (ELIPs) are widely distributed in the plant kingdom. Members of the extended light harvesting complex (LHC) superfamily, <i> ELIP</i>s are expressed in the nucleus and the ELIP protein is transiently localized to the thylakoid membranes. Significant increase in expression of <i> ELIP</i>s has been reported in response to stresses such as high light, high and low temperature, exposure to UV and salinity. ELIP expression also increases at transitional stages of chloroplast development such as deetiolation, conversion to chromoplast, and senescence.</p><p> In se

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14

Siu, Long-kei, and 蕭朗基. "Von Willebrand factor: collagen binding assay(VWF: CBA) assisting in diagnosis of von Willebrand disease inindividuals with menorrhagia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632645.

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15

Rutter, Brian Douglas. "Catch of the Day: A yeast One-Hybrid Assay Identifies a Novel DNA-Binding Domain in Phytophthora Sojae." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1339861904.

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16

Hawkins, Caitlin Marie. "Development of a FRET-based assay to determine binding affinities of RsmG to 30S 5'-domain RNA-protein complexes." Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1557447007620285.

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17

Hata, Misako. "Comparison of a novel cell-based reporter assay and a competitive binding ELISA for the detection of thyrotropin-receptor (TSHR) autoantibodies (TRAb) in Graves' disease patients." Ohio : Ohio University, 2010. http://www.ohiolink.edu/etd/view.cgi?ohiou1262099140.

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18

Kaskar, Khalied. "Evaluation of quantitative motility and zona pellucida binding of human spermatozoa in an assisted reproductive programme." University of the Western Cape, 1994. http://hdl.handle.net/11394/8416.

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>Magister Scientiae - MSc<br>Male factor disorders affect more than 30% of infertile couples. Thus, it has become important to perform a andrological consultation and a basic semen evaluation in all male partners of couples consulting for infertility. The advent and development of assisted reproductive technologies has not only improved clinical results but also enhanced our basic understanding of the physiology of sperm and sperm preparation methods. Assisted reproduction has become among the more successful therapeutic modalities for a wide variety of sperm function disorders e.g. artificial

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19

McGuire, Kelly Lewis. "Governing Dynamics of Divalent Copper Binding by Influenza A Matrix Protein 2 His37 Imidazole." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8647.

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Influenza A is involved in hundreds of thousands of deaths globally every year resulting from viral infection-related complications. Previous efforts to subdue the virus by preventing proper function of wild-type (WT) neuraminidase (N), and M2 proteins using oseltamivir and amantadine (AMT) or rimantadine (RMT), respectively, exhibited success initially. Over time, these drugs began exhibiting mixed success as the virus developed drug resistance. M2 is a proton channel responsible for the acidification of the viral interior which facilitates release of the viral RNA into the host. M2 has a His

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20

Berugoda, Arachchige Danushka M. "Targeting Anti-apoptotic Bcl-2 Proteins with Scyllatoxin-based BH3 Domain Mimetics." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1578306165965544.

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21

Nakath, Gamlath Ralalage Dayan Elshan. "Targeting Melanocortin and Cholecystokinin Receptors via Multivalent Molecules Bearing Peptide Ligands." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338883.

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Peptide receptor overexpression in diseased cells and tissues, including carcinomas provides an opportunity to develop therapeutics and imaging agents that selectively bind to such cells and tissues. This dissertation presents tools and processes that can be utilized to target melanocortin and cholecystokinin receptors through multivalent binding. In Chapter 2, improved synthesis and purification methods are described for the production of Eu-chelated probes that serve to evaluate the binding efficacy of multivalent molecules through competition binding assays. Specifically, a xylenol orange-b

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22

Elmore, Calvin Lee. "MODIFICATION OF THE NUCLEOTIDE COFACTOR-BINDING SITE OF CYTOCHROME P450 REDUCTASE TO ENHANCE TURNOVER WITH NADH IN VIVO." UKnowledge, 2003. http://uknowledge.uky.edu/gradschool_diss/467.

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NADPH-cytochrome P450 reductase is the electron transfer partner for the cytochromes P450, heme oxygenase, and squalene monooxygenase, and is a component of the nitric oxide synthases and methionine synthase reductase. P450 reductase shows very high selectivity for NADPH and uses NADH only poorly. Substitution of tryptophan 677 with alanine (W677A) has been shown by others to yield a 3-fold increase in turnover with NADH, but profound inhibition by NADP+ makes the enzyme unsuitable for in vivo applications. In the present study site-directed mutagenesis of amino acids in the 2'-phosphate-bindi

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23

Bachhawat, Kiran. "Garlic (Allium Sativum) Agglutinin I: Specificity, Binding And Folding Mechanism." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/243.

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Lectins are a class of proteins that bind to carbohydrates with a high degree of specificity. They are involved in various cellular processes such as, host - pathogen interactions, targeting of proteins within cells, cell - cell interaction, cellular segregation and development. They serve as important tools for probing the carbohydrate structures in biological systems such as cell membranes and also as model systems for elucidating protein - carbohydrate interactions. Lectins are distributed ubiquitously in nature ranging from microorganisms to the plants and animals. Plant lectins are a gro

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24

Al-Khafaf, Tanya, Persson Björn Ancker, Johanna Cederblad, et al. "Technology Development in the Field of Ligand Binding Assays : Comparison between ELISA and other methods." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412000.

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25

Somasundaram, Balaji. "A surface plasmon resonance assay to determine the effect of influenza neuraminidase mutations on its affinity with antiviral drugs." Thesis, University of Canterbury. Chemical and Process Engineering, 2013. http://hdl.handle.net/10092/9183.

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The outbreak of pandemic influenza and its ability to spread rapidly makes it a severe threat to public health. Antiviral drugs such as oseltamivir (Roche’s Tamiflu™) and zanamivir (GlaxoSmithKline’s Relenza™) are neuraminidase (NA) inhibitors (NI), which bind more tightly to NA than its natural substrate, sialic acid. However, the virus can acquire resistance to antiviral drugs by developing single point mutations (such as H274Y) in the target protein. Thus in some cases the drugs may not be as effective as expected. The high level of inconsistency exhibited by fluorometric assays and the sho

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26

Scott, Sarah E. "Binding of Sry1, Sry2, and Sry3 to promoter regions of the Rattus norvegicus Ace and Ace2 genes." Akron, OH : University of Akron, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1247602160.

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Thesis (M.S.)--University of Akron, Dept. of Biology, 2009.<br>"August, 2009." Title from electronic thesis title page (viewed 10/7/2009). Advisor, Amy Milsted; Committee members, Monte Turner, Richard Londraville; Department Chair, Monte Turner; Dean of the College, Chand Midha; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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27

Emelie, Zemowska. "Characterization of the binding of the novel compound GT-002 to GABAA receptors in the mammalian brain : Development and validation of a radioligand binding assay. A comparative study to Flumazenil." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143817.

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Gamma-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and inhibits the neurotransmission by targeting the ionotropic transmembrane GABAA receptor. Modulators of the GABAA receptor targets the allosteric binding sites and modifies the GABA effect and these sites acts as superior drug targets within psychopharmacology. Gabather AB has developed the novel compound GT-002 that is known to target the receptor and cause a behavioral effect in rodents. This project characterized the binding of the lead compound GT-002 to GABAA receptor

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28

Smiljanic-Georgijev, Natasha. "Evaluation of the hydrophobic and oligosaccharide binding functions of the G[subscript]M¦2 activator protein by fluorescence dequenching assay." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28763.pdf.

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29

Kalluri, Anila. "EXPRESSION OF CHOLERA TOXIN B SUBUNIT-ROTAVIRUS NSP4 ENTEROTOXIN FUSION PROTEIN IN TRANSGENIC CHLOROPLASTS." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3069.

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Rotavirus, the major cause of life-threatening infantile gastroenteritis, is a member of the Reoviridae family and is considered to be the single most important cause of virus-based severe diarrheal illness in infants and young children particularly 6 months to 2 years of age in industrialized and developing countries. Infection in infants and young children is often accompanied by severe life threatening diarrhea, most commonly following primary infection. Diarrhea is the major cause of death among children around the world. Responsible for 4 to 6 million deaths per year according to the Worl

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30

Brimson, James M. "The pharmacology of the sigma-1 receptor." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518104.

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The sigma-1 receptor, although originally classified as an opioid receptor is now thought of as distinct receptor class, sharing no homology with any other known mammalian protein. The receptor has been implicated with a number of diseases including cancer and depression. Modulation of the receptors activity with agonists has potential antidepressant activity whereas antagonists lead to death of cancer cells. Using radioligand binding assays, utilizing the cancer cell line MDA-MB-468, which highly expresses the sigma-1 receptor, a series of novel specific, high affinity, sigma-1 receptor ligan

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31

Huang, Xinyi. "Enzymatic Characterization of N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50947.

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Mycobacterium species, which contain the causative agent for human tuberculosis (TB), produce inositol derivatives including mycothiol (MSH). MSH is a unique and dominant cytosolic thiol that protects mycobacterial pathogens against the damaging effects of reactive oxygen species and is involved in antibiotic detoxification. Therefore, MSH is considered a potential drug target. The deacetylase MshB catalyzes the committed step in MSH biosynthesis by converting N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) to 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyra

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32

Zargham, Emilia Ohsone. "INVESTIGATIONS OF BINDING TARGETS OF THE PRO-MUTAGEN 2-AMINOANTHRACENE IN FISCHER-344 RATS." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/718.

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Environmental exposures causing ingestions of toxic chemicals, such as the polycyclic aromatic hydrocarbon 2-aminoanthracene (2-AA), may increase the risk of developing cancer and other diseases such as diabetes. To understand the mode of action of 2-AA as it relates to diabetogenic processes and pancreatic cancer, 2-AA binding to soluble protein mixtures was investigated using a novel technique called dynamic isoelectric anisotropy ligand binding assay (DIABLA). Twenty four post-weaning 3-4 week old Fischer-344 (F-344) male rats were fed 0 mg/kg (control), 50 mg/kg (low dose), 75 mg/kg (med

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33

Hutchinson, Dana Sabine 1976. "Pharmacological characterisation and signalling pathways of recombinant and endogenously expressed mouse β₃-adrenoceptors". Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8516.

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34

Roberts, Anthony Simon. "The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15914/.

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This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display to antibody engineering. The variable domain genes were isolated from the hybridoma cell line producing the monoclonal antibody and successfully joined by PCR for the construction of the scFv, named anti-GPE. Sequencing of the gene revealed an unusually short heavy chain CDR2 region. The cloned scFv was expressed in E. coli and purified. Ex

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35

Mackenzie, Janet Fraser. "Development of a radioligand binding assay for detection of gastrin/CCKâ†#â†Bâ†Eâ†Tâ†Aâ†# receptors in the human gastrointestinal tract." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318169.

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36

Larsson, Caroline. "Bacterial Sortase A as a drug target." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176862.

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Sortase A is a housekeeping enzyme of Gram-positive bacteria that catalyses the anchoring of surface proteins to the bacterial peptidoglycan. The enzyme works to establish an interaction between bacteria and host cells and is essential for pathogenesis. This makes Sortase A a potential suitable target for inhibition, in order to treat bacterial infections. In this degree project Sortase A from Staphylococcus aureus was explored and potential inhibitors were investigated by performing enzyme activity and bacterial binding assays. A robust FRET assay was developed and optimized for a recombinant

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37

Ansideri, Francesco [Verfasser], and Pierre [Akademischer Betreuer] Koch. "Multiple strategies targeting c-Jun N-terminal kinases : synthesis of novel inhibitors and development of a new binding assay methodology / Francesco Ansideri ; Betreuer: Pierre Koch." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1199268585/34.

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Hemmingsson, Lovisa, and Johan Klasén. "In vitro studies of Thiopurine S-Methyltransferase: Ligand binding interactions and development of a new enzymatic activity assay for TPMTwt, TPMT*6 and TPMT*8." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119652.

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Acute lymphoblastic leukemia, one of the most malignant cancer forms in children is commonly treated with the thiopurine 6-mercaptopurine (6-MP) in combination with a high dose of methotrexate (MTX). 6-Mercaptopurine is in the body metabolized by the enzyme thiopurine S-methyltransferase (TPMT). Polymorphic variants of TPMT express different catalytic activities, and for this reason the dosage of 6-MP needs to be individualized. In order to better optimize the treatment it is important to understand how mutations in TPMT affect its enzymatic activity. In this thesis we have investigated how th

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Kröger, Tobias [Verfasser], Holger [Gutachter] Gohlke, and Georg [Gutachter] Groth. "Assay development and optimization for the validation and quantification of NHR2 tetramerization inhibitors and prediction of the binding mode / Tobias Kröger ; Gutachter: Holger Gohlke, Georg Groth." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1172967989/34.

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Myrie, Latoya T. "Optimization of the conditions necessary to show binding of the Plasmodium yoelii RHOP-3 rhoptry protein to mouse erythrocytes." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1213361087.

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Thesis (M.S.)--Cleveland State University, 2008.<br>Abstract. Title from PDF t.p. (viewed on July 29, 2008). Includes bibliographical references (p. 66-73). Available online via the OhioLINK ETD Center. Also available in print.

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Connell, Bridgette Janine. "Development of a binding assay between the HIV-1 envelope protein (gp120) and coreceptors CCR5/CXCR4 by Surface Plasmon Resonance: Screening and optimization of viral entry inhibitors." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-01063128.

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La gp120 du VIH-1 se fixe aux héparane sulfate (HS) cellulaires, par le biais de la boucle V3 ce qui favorise l'infectivité virale. Cependant, une polyanion solubles (HS12), conjugués à CD4 (mCD4-HS12) a des propriétés antivirales et a montré in vitro une activité contre le VIH-1 à de concentrations nM. En raison de la complexité structurale des HS, le criblage d'oligosaccharides différenciellement sulfatés pour améliorer l'activité de la molécule serait trop difficile. En vue d'obtenir une molécule plus spécifique, de plus haute affinité et plus facile à produire, des peptides mimant les HS o

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Balanarasimha, Madhumitha. "STRUCTURAL AND FUNCTIONAL ALTERATION OF FULL LENGTH PPARα AND LXRα BY FATTY ACIDS AND THEIR THIOESTERS". Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1324531803.

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Pinyot, Comelles Armand 1981. "Assessment of growth hormone secretagogues in anti-doping." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/96913.

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La present tesis doctoral desenvolupa una nova metodologia analítica antidopatge. Degut a que actualment la detecció de l'abús d'hormona del creixement recombinant està relativament resolt, es tem que els secretagogs de la hormona del creixement (GHS) siguin el relleu natural ja que es creu provoquen efectes anabòlics semblants. L'objectiu de la tesi és la detecció de secretagogs de l'hormona del creixement (GHS) a partir de mostres d’orina. Els GHS presenten gran diversitat estructural que fa difícil una única determinació química convencional. Per això s'ha optat per utilitzar la seva pr

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Tevis, Denise Susanne. "Heterocyclic Diamidines Induce Sequence Dependent Topological Changes in DNA; A Study Using Gel Electrophoresis." unrestricted, 2009. http://etd.gsu.edu/theses/available/etd-04162009-154105/.

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Thesis (M.S.)--Georgia State University, 2009.<br>Title from file title page. W. David Wilson, committee chair; Stewart A. Allison, Kathryn B. Grant, committee members. College of Arts and Sciences.Description based on contents viewed July 22, 2009. Includes bibliographical references (p. 85-87).

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Wirth, Pamela. "THE PROGNOSTIC POTENTIAL OF THE EPIDERMAL GROWTH FACTOR RECEPTOR AND NUCLEAR FACTOR KAPPA B PATHWAYS AND ASSOCIATED THERAPEUTIC STRATEGIES IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2229.

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Little is known about the signaling pathways that contribute to treatment response in advanced stage head and neck tumors. Increased expression of epidermal growth factor receptor (EGFR) and downstream pathways such as nuclear factor kappa B (NFκB) are implicated in aggressive tumor phenotypes and limited response to therapy. This study explored the rationale for combining the proteasome inhibitor bortezomib with the EGFR inhibitor gefitinib in a subset of head and neck squamous cell carcinomas with high EGFR gene amplification. Drug responses of gefitinib and bortezomib as single agents and i

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Shi, Zhen. "Heme biosynthesis: structure-activity studies of murine ferrochelatase." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001450.

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47

Lai, John. "Functional analyses of polymorphisms in the promoters of the KLK3 and KLK4 genes in prostate cancer." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16454/.

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This PhD aimed to elucidate the mechanisms by which polymorphisms may alter androgen-induced transactivation of androgen receptor (AR) target genes which may be important in prostate cancer aetiology. The second aspect of this PhD focused on identifying and characterising functional polymorphisms that may have utility as predictive risk indicators for prostate cancer and which may aid in earlier therapeutic intervention and better disease management. Analyses were carried out on the kallikrein-related peptidase 3 (KLK3), also known as the prostate specific antigen (PSA), gene and the kallikrei

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48

Clement, Ella Chow. "Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/28271.

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Numerous previous studies of GABAAR ligands have suggested that GABAAR agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7-6.0 Ã ). We have demonstrated that monomeric, homodimeric and heterodimeric non-zwitterionic GABA amides are partial, full, or superagonists at the murine GABAA receptor (GABAAR). The agonism of these GABA amides is comparable to that of THIP, as shown by in vitro assay results. The assay data indicate that the agonism of GABA amides is tether length-dependent. Optimum agonism is achieved with a tether length of four

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49

Silva, Igor Henrique Sena da [UNESP]. "Interação da toxina Cry1ac de Bacillus thuringiensis às microvilosidades apicais das células colunares do intestino médio de Helicoverpa armigera Hübner, 1805 (Lepidoptera: Noctuidae) em diferentes ínstares larvais." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151547.

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Submitted by IGOR HENRIQUE SENA DA SILVA null (igor.sena@outlook.com.br) on 2017-09-05T13:59:07Z No. of bitstreams: 1 DISSERTAÇÃO_Igor_Henrique_Sena_Silva.pdf: 1536012 bytes, checksum: da24e2e008037696caee4c8842fc8f05 (MD5)<br>Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-09-06T13:13:51Z (GMT) No. of bitstreams: 1 silva_ihs_me_jabo.pdf: 1536012 bytes, checksum: da24e2e008037696caee4c8842fc8f05 (MD5)<br>Made available in DSpace on 2017-09-06T13:13:51Z (GMT). No. of bitstreams: 1 silva_ihs_me_jabo.pdf: 1536012 bytes, checksum: da24e2e008037696caee4c8842fc8f0

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Boone, Lindsey R. "Thyroid Hormone Regulation of Cholesterol Metabolism." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003089.

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