Relevant bibliographies by topics / Binding posts

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Binding posts'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Binding posts"

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Vujevic, D. "Transient thermoelectromotive forces on binding posts." IEEE Transactions on Instrumentation and Measurement 45, no. 1 (1996): 341–44. http://dx.doi.org/10.1109/19.481367.

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KIRPSZA, Adam KIRPSZA. "Duch d’Hondta w Strasburgu. Zasada proporcjonalnej dystrybucji stanowisk w Parlamencie Europejskim." Przegląd Politologiczny, no. 3 (November 2, 2018): 147–66. http://dx.doi.org/10.14746/pp.2011.16.3.9.

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Proportionality is an intrinsic feature of parliamentary democracy. It is a principle stating that, depending on its size, each political party has a commensurate ability to influence legislature. This is confirmed by comparative studies which show that proportionality is a significant principle in the distribution of parliamentary posts in a majority of West European states. Consequently, even deputies from the smallest parties can chair commissions or lead sessions of the chambers, and by this token participate in the political decision-making process. This softens the domination of the majority party and – in line with Arend Lijphart’s concept – generates consensual democracy, based on the search for broad compromises instead of simply outvoting the opponent. Given this picture, a question emerges whether the situation is similar in the representative institution of the European Union, i.e. the European Parliament. The paper answers this question positively. The standard of proportionality has strong roots in the European Parliament forming a fundamental principle expressed in terms of d’Hondt’s formula applied to distribute posts among different political groups. This mainly concerns the division of the members of the Presidium and commission chairmen, who exercise the most important decisive functions. The implementation of the idea of appropriate representation may not be ideal, but divergences are rare, insignificant and usually they result from political bargaining that favors smaller fractions. The proportionality principle is also binding when distributing parliamentary posts inside political groups. There is a strong and positive correlation between the size of national delegations and the number of key posts they obtain in the Parliament – members of the Presidium, commission chairmen and coordinators. Only in the case of the latter is proportionality subjected to certain distortions, following from their key political importance. This, however, does not interfere with the general picture of symmetric participation of national groups in appointing parliamentary posts. In conclusion, the standard of proportionality allows all political groups to adequately participate in the work of the European Parliament, which deserves to be emphasized, the more so, as it is not formalized.
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Lehto, Mari. "Bare Flesh and Sticky Milk: An Affective Conflict Over Public Breastfeeding." Social Media + Society 5, no. 4 (2019): 205630511988169. http://dx.doi.org/10.1177/2056305119881696.

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On New Year’s Day 2016, a photograph of a breastfeeding woman taken by a Finnish celebrity sparked a social media debate over mothers nursing in public. By analyzing Instagram posts and a discussion forum thread, this article explores the affective body politics involved in this short-lived yet intense social media debate. It examines the power of hashtags and images in mobilizing motherhood as a site of political agency. Concurrently, it investigates how social media users negotiated the appropriate public presentations of the female body and how the celebrity’s gayness became an object of negative affect. The analysis of the incident makes visible how social norms concerning motherhood and heteronormativity are articulated in social media. It also demonstrates how affect sticks to images, texts, and bodies and becomes a binding force in social media discussions concerning them. The article argues that Instagram’s hashtag practices facilitated affective engagement for those following #teriniitti. It further argues that the affective dynamics of the case demonstrate how affective intensities stick on gay bodies and lactating bodies as objects of disgust, fascination, and desire.
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Roscoe, Lucy. "A thing to hold: The visual language of the book form." Journal of Illustration 6, no. 1 (2019): 77–98. http://dx.doi.org/10.1386/jill_00005_1.

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This article considers the book form itself as an ornamental object. The binding, paper and ink appeal to the senses and all add to experience of the reader. The future is a place of e-books, online publications and Instagram posts, and yet this arguably makes the carefully considered design of the book form even more important in the physical books that we do chose to view. The study examines a series of examples, drawing from artists' books, pop-up books and mainstream publishing. The work draws strongly on the collection of pop-up books at the National Library of Scotland and the artists' book collection at Edinburgh College of Art, looking at both historical and contemporary works. Initially exploring how the form of the book itself can visually communicate a narrative, the study goes on reflect on the emotion associated with opening a pop-up book, as if in the presence of a theatrical production, made more extreme by the embellishments employed. The place of the book form within a digital world is considered and, finally, the emergence of decorative books in the form of colouring books related to mindfulness.
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Babiychuk, Eduard B., and Annette Draeger. "Annexins in Cell Membrane Dynamics." Journal of Cell Biology 150, no. 5 (2000): 1113–24. http://dx.doi.org/10.1083/jcb.150.5.1113.

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The sarcolemma of smooth muscle cells is composed of alternating stiff actin-binding, and flexible caveolar domains. In addition to these stable macrodomains, the plasma membrane contains dynamic glycosphingolipid- and cholesterol-enriched microdomains, which act as sorting posts for specific proteins and are involved in membrane trafficking and signal transduction. We demonstrate that these lipid rafts are neither periodically organized nor exclusively confined to the actin attachment sites or caveolar regions. Changes in the Ca2+ concentration that are affected during smooth muscle contraction lead to important structural rearrangements within the sarcolemma, which can be attributed to members of the annexin protein family. We show that the associations of annexins II, V, and VI with smooth muscle microsomal membranes exhibit a high degree of Ca2+ sensitivity, and that the extraction of annexins II and VI by detergent is prevented by elevated Ca2+ concentrations. Annexin VI participates in the formation of a reversible, membrane–cytoskeleton complex (Babiychuk, E.B., R.J. Palstra, J. Schaller, U. Kämpfer, and A. Draeger. 1999. J. Biol. Chem. 274:35191–35195). Annexin II promotes the Ca2+-dependent association of lipid raft microdomains, whereas annexin V interacts with glycerophospholipid microcompartments. These interactions bring about a new configuration of membrane-bound constituents, with potentially important consequences for signaling events and Ca2+ flux.
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Re, Suyong, Hiraku Oshima, Kento Kasahara, Motoshi Kamiya, and Yuji Sugita. "Encounter complexes and hidden poses of kinase-inhibitor binding on the free-energy landscape." Proceedings of the National Academy of Sciences 116, no. 37 (2019): 18404–9. http://dx.doi.org/10.1073/pnas.1904707116.

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Modern drug discovery increasingly focuses on the drug-target binding kinetics which depend on drug (un)binding pathways. The conventional molecular dynamics simulation can observe only a few binding events even using the fastest supercomputer. Here, we develop 2D gREST/REUS simulation with enhanced flexibility of the ligand and the protein binding site. Simulation (43 μs in total) applied to an inhibitor binding to c-Src kinase covers 100 binding and unbinding events. On the statistically converged free-energy landscapes, we succeed in predicting the X-ray binding structure, including water positions. Furthermore, we characterize hidden semibound poses and transient encounter complexes on the free-energy landscapes. Regulatory residues distant from the catalytic core are responsible for the initial inhibitor uptake and regulation of subsequent bindings, which was unresolved by experiments. Stabilizing/blocking of either the semibound poses or the encounter complexes can be an effective strategy to optimize drug-target residence time.
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Nelson, Stephen C. "Playing Favorites: How Shared Beliefs Shape the IMF's Lending Decisions." International Organization 68, no. 2 (2014): 297–328. http://dx.doi.org/10.1017/s0020818313000477.

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AbstractInternational organizations (IOs) suffuse world politics, but the International Monetary Fund (IMF) stands out as an unusually important IO. My research suggests that IMF lending is systematically biased. Preferential treatment is largely driven by the degree of similarity between beliefs held by IMF officials and key economic policy-makers in the borrowing country. This article describes the IMF's ideational culture as “neoliberal,” and assumes it to be stable during the observation window (1980–2000). The beliefs of top economic policy-makers in borrowing countries, however, vary in terms of their distance from IMF officials' beliefs. When fellow neoliberals control the top economic policy posts the distance between the means of the policy team's beliefs and the IMF narrows; consequently, IMF loans become less onerous, more generous, and less rigorously enforced. I gathered data on the number of conditions and the relative size of loans for 486 programs in the years between 1980 and 2000. I collected data on waivers, which allow countries that have missed binding conditions to continue to access funds, as an indicator for enforcement. I rely on indirect indicators, gleaned from a new data set that contains biographical details of more than 2,000 policy-makers in ninety developing countries, to construct a measure of the proportion of the top policy officials that are fellow neoliberals. The evidence from a battery of statistical tests reveals that as the proportion of neoliberals in the borrowing government increases, IMF deals get comparatively sweeter.
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ZHONG, SHIJUN, and ALEXANDER D. MACKERELL. "POSE SCALING: GEOMETRICAL ASSESSMENT OF LIGAND BINDING POSES." Journal of Theoretical and Computational Chemistry 07, no. 04 (2008): 833–52. http://dx.doi.org/10.1142/s0219633608004155.

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A descriptor, the pose scaling factor, is proposed to quantitatively evaluate the geometrical match between a ligand and a target binding site. The pose scaling factor can be used to readily rank results of target-based in silico database screening or docking on large numbers of compounds. Such an approach will be of utility in the development and refinement of docking algorithms.
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TANIDA, Yoshiaki, and Azuma MATSUURA. "Binding Free Energy Calculation of Small Molecules to Rna with Multiple Binding Poses." Journal of Computer Chemistry, Japan 14, no. 3 (2015): 80–82. http://dx.doi.org/10.2477/jccj.2015-0029.

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Nguyen, Nguyen Thanh, Trung Hai Nguyen, T. Ngoc Han Pham, et al. "Autodock Vina Adopts More Accurate Binding Poses but Autodock4 Forms Better Binding Affinity." Journal of Chemical Information and Modeling 60, no. 1 (2019): 204–11. http://dx.doi.org/10.1021/acs.jcim.9b00778.

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Dissertations / Theses on the topic "Binding posts"

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Kalibjian, J. R., T. J. Voss, J. J. Yio, and B. Hedeline. "Automated Binding of Attributes to Telemetry Data." International Foundation for Telemetering, 1993. http://hdl.handle.net/10150/608880.

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International Telemetering Conference Proceedings / October 25-28, 1993 / Riviera Hotel and Convention Center, Las Vegas, Nevada<br>An automated method is described for binding attributes to extracted data from a telemetry stream. These attributes can be used by post processing utilities to facilitate efficient analysis. A practical implementation of such a scheme is described.
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Wolf, Joshua Jaeger. "Post-transcriptional coordination by an RNA-binding protein." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57893.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular processes in response to various stimuli. Filamentous growth in Saccharomyces cerevisiae is a morphogenetic switch that occurs in response to nitrogen starvation and requires alterations in cell growth, cell cycle, and cell wall functions. Tyl element retrotransposition is also induced under conditions of nitrogen starvation. I describe a role for the RNA-binding protein Khdl in regulating these two responses to environmental stress through its mRNA targets. I identified the RNA targets of Khdl using in vivo crosslinking and immunoprecipitation (CLIP), combined with deep sequencing. This produced a high-resolution map of Khdl binding sites across the transcriptome, and provided unprecedented insight into its biological functions. Khdl regulates multiple post-transcriptional regulatory loops to coordinate the components of filamentous growth and Tyl retrotransposition. Although similar mechanisms were known to transcriptionally regulate these processes, the posttranscriptional coordination is a novel discovery. The feed-forward regulation that Khdl confers on FLO11, which encodes a protein required for filamentous growth, enables asymmetric expression between mother and daughter cells to switch between filamentous and yeast form growth. In this thesis, I describe regulation of gene expression by RNA-binding proteins, methods to identify their target transcripts and recognition sequences, the KH domain, known functions of Khdl, and the phenotypes it coordinates. My work represents the first application of CLIP to budding yeast, and the growing understanding of RNA-binding proteins in this organism facilitated the placement of Khdl into its posttranscriptional regulatory network. While many questions remain regarding the role Khdl plays in regulating cellular activities, this thesis addresses its direct role in key processes.<br>by Joshua Jaeger Wolf.<br>Ph.D.
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Taylor, W. J. "Post-synaptic actions of opiate peptides and gamma-aminobutyrate." Thesis, University of Leeds, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372580.

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Tierney, Marcus John 1973. "Post-transcriptional regulation of plasminogen activator inhibitor type 2." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8496.

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Ademokun, Alexander. "Post-transcriptional regulation of BLIMP-1 by the RNA-binding protein TIS11b." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612489.

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Sawicka, Kirsty J. "Post-transcriptional regulation of gene expression by the polypyrimidine tract binding protein." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537674.

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Nguyen, Chi Mai. "Post-transcriptional regulation during spermatogenesis : Role of the RNA-binding protein hu." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/365/.

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La spermatogenèse est un processus élaboré permettant d'une part le maintien de cellules souches par divisions mitotiques et d'autre part la production de spermatozoïdes par différenciation. Au cours des dernières étapes de la différenciation, la chromatine se compacte, ne laissant plus à la cellule la possibilité de transcrire ses gènes. Du fait de l'arrêt brutal de la transcription, bien avant la fin du processus de différenciation, la cellule germinale utilise le stock d'ARN messagers (ARNm) préexistants pour finaliser sa différenciation. Ce phénomène repose sur la régulation fine du stockage et de la traduction des ARNm au cours du temps, deux régulations post-transcriptionnelles encore très peu documentées dans les cellules germinales. Au cours de ma thèse je me suis intéressée au rôle potentiel de deux protéines de liaison à l'ARN exprimées dans le testicule de souris: HuR/ELAVL1 et AUF1/hnRNP D. Dans les cellules somatiques, ces protéines lient les séquences riches en adénines et uridines (AU-rich element ou ARE) localisées dans la région 3' non codante de certains ARNm (ARN à ARE). HuR protége de la dégradation ses ARN à ARE cibles et favorise leur traduction, alors qu'AUF1 induit leur dégradation. Afin d'étudier la contribution d'HuR et d'AUF1 aux mécanismes post-transcriptionnels indispensables au bon déroulement de la spermatogénèse, nous avons dans un premier temps examiné leur patron d'expression. Nous avons montré que l'expression d'HuR est étroitement régulée au cours de la spermatogénèse, alors que celle d'AUF1 est ubiquitaire. Dans un second temps, nous avons utilisé des lignées de souris transgéniques surexprimant HuR (HuRtg) ou AUF1 (AUF1tg) établies au laboratoire et montré que la surexpression d'HuR et non celle d'AUF1 altère la spermatogenèse, entraînant leur stérilité dans 25% des cas (Sertoli Cells Only syndrome). Par la suite, nous avons mis évidence que de nombreux ARN à ARE, naturellement abondamment exprimés dans le testicule, sont dérégulés dans les cellules germinales HuRtg et AUF1tg. Une étude approfondie des ARN cibles d'HuR et d'AUF1, a révélé que ces deux protéines ont une activité différente car elles s'associent à des ARN différents dans les cellules germinales. .<br>Spermatogenesis, the elaborate process by which sperm are produced, is marked by dramatic proliferation and differentiation. During the late steps of spermatogenesis, transcription suddenly ceases prior the end of differentiation, because of drastic epigenetic modifications that result in chromatin compaction. Thus, haploid germ cells make use of extensive temporal mRNA storage and translation regulation to ensure stage-specific protein synthesis. Factors and cellular compartments involved in these post-transcriptional controls are still poorly understood. During my PhD, I hypothesized that the two RNA binding proteins HuR/ELAVL1 and AUF1/hnRNP D, might play a role in these controls. They bind AU-rich element-containing mRNAs (ARE-mRNAs) in somatic cells and regulate their stability and translation: HuR protects ARE-mRNAs from degradation and favours their translation, whereas AUF1 usually induces their degradation. First, to investigate the contribution of HuR and AUF1 to the post-transcriptional mechanisms occurring in germ cells, I used transgenic mice derived in our laboratory overexpressing HuR (HuRtg) and AUF1 (AUF1tg) in their testes. Strikingly, whereas spermatogenesis proceeded normally in AUF1tg mice, HuR overexpression impaired spermatogenesis, revealing the importance of a regulated expression of HuR to fulfill male germ cell differentiation. The comparative analysis of AU-transcriptome of pre-pubertal wild type testes with that of HuRtg and AUF1tg testes, combined with computational analyses and RNA/Protein immunoprecipitation experiments, revealed that these two proteins regulate different targets mRNAs and thus exhibit different activities. .
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Almlöf, Tova. "Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2675-1.

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Liu, Qingbin. "Post-translational modification on arginine and function of CCAAT/enhancer binding protein alpha." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16620.

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Der Transkriptionsfaktor CCAAT/enhancer-binding protein α (C/EBPα) kontrolliert Zellzyklusarrest und terminale Differenzierung von neutrophilen Granulozyten und Adipozyten. Mutationen von C/EBPα treten häufig im Zusammenhang mit akuter myeloischer Leukämie auf. Massenspektrometrische Untersuchungen zeigten, dass C/EBPα an mehreren konservierten Argininen citrunilliert ist, einschließlich R297 in der C-terminalen basischen Region von C/EBPα. Mutationen von C/EBPα R297 wurden bereits beschrieben, weshalb der Schwerpunkt dieser Arbeit auf die Analyse der Modifikation dieses Aminosäurerestes gelegt wurde. Die Ergebnisse zeigen, dass die Peptidyl-Arginin-Deaminase (PADI4) mit C/EBPα interagiert und an mehreren Aminosäureresten citrunilliert. Citrunillierung oder Mutation von R297 beeinflusst die Aktivität von C/EBPα, einschließlich DNA-Bindung und Interaktion mit Partnerproteinen. Mutationsanalysen legen nahe, dass die positive Ladung des Aminosäurerestes R297 für die Bindung an cis-regulatorische DNA-Elemente, Protein Interaktionen, Genaktivierung, Fettzelldifferenzierung und Zellzyklusarrest ausschlaggebend ist. Knock-down von PADI4 in der myeloischen Vorläufer-Zelllinie 32D oder in der leukämischen U937 Zelllinie induziert Granulozyten-Differenzierung, möglicherweise durch Blockierung der PADI4-vermittelten Citrunillierung und Inaktivierung von C/EBPα. Zusammengefasst ergibt sich aus den Daten, dass PADI4 die positiv-geladene Seitenkette von C/EBPα R297 in eine ungeladene, citrunillierte Form umwandelt, die die Assoziation mit DNA destabilisiert und die C/EBPα-E2F-Interaktion beeinflusst, was wiederum das Gleichgewicht zwischen Proliferation und Differenzierung bestimmt.<br>The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) coordinates cell cycle arrest and terminal differentiation of neutrophil granulocytes and adipocytes. Mutations in C/EBPα are frequently associated with acute myeloid leukemia. Mass spectrometric analysis revealed that citrullination occurred on multiple conserved C/EBPα arginine residues including R297 in the C/EBPα basic region. C/EBPα R297 was previously reported to be mutated in acute myeloid leukemia and we therefore focused on the modification this residue. Data presented here show that peptidylarginine deiminase 4 (PADI4) interacts with and citrullinates C/EBPα at several sites. Citrullination or mutation of R297 dramatically changed C/EBPα activities, including DNA binding and interaction with protein partners. Mutational analysis demonstrated that the positive charge of residue R297 was critical for binding to cis-regulatory sites on DNA, gene activation, adipocytic differentiation, and cell cycle arrest. Knock down of PADI4 in the myeloid precursor cell line 32D or U937 leukemia cells induced granulocyte differentiation, potentially through relieving PADI4 mediated citrullination and inactivation of C/EBPα. Taken together, the data suggest that PADI4 converts the positive C/EBPα R297 side chain to the non-charged citrulline side chain which destabilizes the association with DNA and affects C/EBPα - E2F interaction that determines the balance between proliferation and differentiation.
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Zhou, Shanggen. "Post-translational regulation of CCAAT/enhancer binding protein [delta] (C/EBP[delta]) by ubiquitin family proteins." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195227986.

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Books on the topic "Binding posts"

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Survey, Illinois State Water. Streambank erosion: Solve the problem with the willow-post method. Illinois State Water Survey, 1991.

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Hullebroeck, Margo. Characterization of the post-translational modifications of kainate binding proteins and glutamate receptors. National Library of Canada = Bibliothèque nationale du Canada, 1992.

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Office, World Bank Indonesia. Aceh growth diagnostic: Identifiying the binding constraints to growth in a post-conflict and post-disaster environment : investing in Indonesia's institutions for inclusive and sustainable development. The World Bank Office Jakarta, 2009.

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Post-transcriptional regulation by STAR proteins : control of RNA metabolism in development and disease. Springer Science+Business Media, LLC, 2010.

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Symposium, Italian Poetry Society of America. Binding the lands: Present day poets, present day poetry : proceedings of the Third Annual Symposium of IPSA (Italian Poetry Society of America) : New York, November 11-13, 1999. New Jersey Institute of Italian and Italian American Heritage Studies, 2004.

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Yuter, Seymour C. Mefta: A key to Jewish and Israel-Arab peace, nuclear peace, and properity : a Middle East free trade area (Mefta) for Jewish and Israel-Arab peace, a universally-binding test ban to block Iran and North Korea bombs, and cheap oil to spur economy. 2nd ed. Expedited Pub., 1996.

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King, Stephen. The Stand (Turtleback School & Library Binding Edition). Turtleback Books, 2011.

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McCarthy, Cormac. The Road (Turtleback School & Library Binding Edition). Turtleback Books, 2007.

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King, Stephen. Night Shift (Turtleback School & Library Binding Edition). Turtleback Books, 2011.

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Parker, Philip M. The 2007-2012 World Outlook for Printing and Binding of Hardbound College and Post-High School Level Textbooks. ICON Group International, Inc., 2006.

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Book chapters on the topic "Binding posts"

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Lovci, Michael T., Mario H. Bengtson, and Katlin B. Massirer. "Post-Translational Modifications and RNA-Binding Proteins." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29073-7_12.

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Baroni, Timothy E., Sridar V. Chittur, Ajish D. George, and Scott A. Tenenbaum. "Advances in RIP-Chip Analysis: RNA-Binding Protein Immunoprecipitation-Microarray Profiling." In Post-Transcriptional Gene Regulation. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-033-1_6.

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Müller, P. P., S. Blum, M. Altmann, S. Lanker, and H. Trachsel. "Initiation Factors Involved in mRNA Binding to Ribosomes in Saccharomyces Cerevisiae." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_45.

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Russell, John H., and Rawleigh C. Howe. "Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic T Lymphocytes." In Advances in Experimental Medicine and Biology. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-8326-0_30.

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Malim, Michael H., David F. McCarn, Laurence S. Tiley, and Bryan R. Cullen. "The HIV-1 REV Trans-Activator is a Sequence Specific RNA Binding Protein." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_34.

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David, Frank S., Andreas Kern, and Eugene E. Marcantonio. "Post-Ligand Binding Events: Outside-In Signaling Through the Integrins." In Integrin-Ligand Interaction. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4757-4064-6_11.

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Frederickson, R., A. Lazaris-Karatzas, and N. Sonenberg. "The Eukaroyotic mRNA Cap Binding Protein (eIF-4E): Phosphorylation and Regulation of Cell Growth." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_46.

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Bailey, Christopher R., Allison M. Greene, and Alexander Neumeister. "PET Ligand-Binding-Specific Imaging Proteins in the Brain: The Application in PTSD." In Sleep and Combat-Related Post Traumatic Stress Disorder. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7148-0_13.

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Ma, C., J. E. Gonzalez, C. C. Case, T. Sonnabend, J. Rayner, and R. W. Simons. "Post-Transcriptional Control of IS10 Transposase Expression: Antisense RNA Binding and Other Conformational Changes Affecting Messenger RNA Stability and Translation." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_10.

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Riederer, Peter, Kurt Jellinger, and Eberhard Gabriel. "3H-Spiperone Binding to Post Mortem Human Putamen in Paranoid and Nonparanoid Schizophrenics." In Clinical Psychopathology Nomenclature and Classification. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-5049-9_97.

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Conference papers on the topic "Binding posts"

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Feghhi, Shirin, Adam D. Munday, Wes W. Tooley, Jose A. Lopez, and Nathan J. Sniadecki. "E-Beam Nanopost Arrays Reveal That Glycoprotein Ib-IV-X Complex and Von Willebrand Factor Interactions Transmit Platelet Cytoskeletal Forces." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14694.

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We have developed a new tool to measure the contractility of single platelets. This tool consists of an array of nano-scale polydimethylsiloxane (PDMS) posts. Von Willebrand factor (VWF) and a recombinant protein encompassing the GPIb-IX-V binding region of VWF (A1 domain) were used to study the role of GPIb-VWF interactions in platelet contractility. Platelets were treated with AK2 and 7E3 antibodies to block platelet adhesion through receptors GPIb and α IIbβ 3, respectively. Platelets treated with these antibodies showed reduced spread area and forces in comparison to untreated platelets on VWF. Furthermore, platelets were able to generate contractile forces on substrates coated with A1 domain of VWF. These results suggest that platelet contractile forces can be transmitted through a non-integrin receptor, such as GPIb.
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2

SUKHORUCHKIN, S. I. "CLUSTER EFFECTS IN NUCLEAR BINDING ENERGIES." In Proceedings of the International Symposium on Post-Symposium of YKIS01. WORLD SCIENTIFIC, 2002. http://dx.doi.org/10.1142/9789812777577_0044.

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Liu, Yaling, Kytai Nguyen, Manohara Mariyappa, Soujanya Kona, and Jifu Tan. "A Coupled Particle-Continuum Model of Nanoparticle Targeted Delivery Under Vascular Flow With Experimental Validation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19035.

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Nanomedicine poses a new frontier in medical technology with the advantages of targeted delivery and patient specific design. In applications of nanoparticle targeted drug delivery, the delivery efficiency is controlled by the physical properties of the nanoparticle such as its size, shape, ligand density, as well as external environmental conditions such as flow rate and blood vessel diameter. Proper drug dosage choice relies on determination of the attachment and detachment rates of the nanoparticles at the active region and the understanding of the complex process of targeted drug delivery. A few particulate models have been proposed to study the adhesion individual spherical or non-spherical nanoparticles on receptor coated wall. Meanwhile, continuum convection-diffusion-reaction models have been widely used to calculate the drug concentration under various conditions, which usually assumes specific binding and de-binding constants. In reality, these binding and de-binding rates largely vary with physical properties of the particles and local flow conditions. However, there has not been any study that links the particulate level nanoparticle size and shape information to the system level bounded particle concentration. A hybrid particle binding dynamics and continuum convection-diffusion-reaction model is presented to study the effect of shear flow rate and particle size on binding efficiency. The simulated concentration of bounded nanoparticles agrees well with experimental results in flow chamber studies.
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4

de Agostini, A., J. Marcum, and R. Rosenberg. "THE BINDING OF ANTITHROMBIN TO CAPILLARY ENDOTHELIAL CELLS GROWN IN VITRO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643343.

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Cloned endothelial cells from rat epididymal fat pads synthesize anticoagulantly active heparan sulfate proteoglycans containing the disaccharide, GlcA→ AMN-3,6-O-SO3, which is a marker for the antithrombin-binding domain of heparin. To demonstrate that antithrombin (AT) binds to cell surface heparan sulfate, a binding assay employing 125I-AT and cell monolayers has been developed. Post-confluent endothelial cells (7 days) were incubated with radiolabeled AT for 1 h at 4° and washed with PBS. Bound radioactivity was quantitated after solubilizing whole cells. Under these conditions, ∼1% (2174±50 cpm/5x104 cells) of the 125I-AT bound to the endothelial cell monolayer, whereas none of the radiolabeled protein bound to CHO cells or bovine smooth muscle cells. Utilization of unlabeled AT (1 μM) in experiments conducted as described above resulted in a reduction (73%) of the binding of the labeled species to endothelial cells. To assess whether heparan sulfate was responsible for AT binding, cell monolayers were incubated for 1 h at 37° with purified Flavobacterium heparinase (0.2 units). Over 90% of 125I-AT binding to these cellular elements was suppressed with the bacterial enzyme. Internalization of radiolabeled AT by endothelial cells was examined by incubating the protease inhibitor and cells at 4° and 37 . An initial rapid binding was observed at both temperatures. At 4° AT binding plateaued within 15 min, whereas at 37° binding did not plateau until 60 min and was 30% greater than that observed at 4. These data suggest that surface-associated AT can be internalized by endothelial cells. In addition, AT binding was shown to increase with the length of endothelial cell postconfluence, indicating an accumulation of heparan sulfate by these cells during quiescence. In conclusion, our studies support the hypothesis that the vascular endothelium is coated with heparan sulfate-bound AT, which is responsible for the antithrombotic properties of these natural surfaces.
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5

Steurer, G., H. Sinzinger, and P. Fitscha. "THE PLATELET “REBOUND-PHENOMENON” DURING PROLONGED, CONTINUOUS PGI2 INFUSION OCCURS AT THE RECEPTOR LEVEL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643452.

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During earlier attempts in optimizing the therapeutic regimen with PGI2 we were able to discover an “ intra- and post-infusion platelet rebound” being characterized by an activated platelet function and a diminished responsiveness of platelets to the action of PGI2 in-vitro.In order to verify this phenomenon at the receptor level we infused continuously 6 patients suffering from peripheral vascular disease (PVD) with PGI2 at a rate of 5 ng/kg/min for 5 days. Anticoagulated venous blood has been drawn at different intervals. Saturation binding experiments on platelet membrane fraction have been performed using [3H]iloprost, a stable PGI2 analoque. Analysis of the binding data according to Scatchard demonstrated a decrease of receptor affinity with an increased number of binding sites.It is concluded, that intrainfusion rebound occurs at the receptor level, whereas the postinfusion rebound does not. This is a further piece of evidence that an intermittent infusion regimen is preferable.
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6

Burkhart, Richard, Danielle Pineda, Joseph Cozzitorto, Charles Yeo, Jonathan Brody, and Jordan Winter. "Abstract 5144: RNA-binding protein HuR supports post-transcriptional regulation of pancreatic cancer cell metabolism." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5144.

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7

Kress, V., A. Bittner, M. Kopp, K. Weidner, and J. Junge-Hoffmeister. "Mütterliche Feinfühligkeit, Bindung und psychische Belastung – Eine Prä-Post-Untersuchung einer Mutter-Kind-Behandlung bei postpartalen Erkrankungen." In Kontroversen und Gewissheiten in der Psychosomatischen Frauenheilkunde. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1622751.

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8

GRUEL, Y., P. MOALIC, E. DUROUCHET, C. GUEROIS, B. DELAHOUSSE, and J. LEROY. "LEVELS OF TOTAL AND FREE PROTEIN S DURING NORMAL AND PATHOLOGICAL PREGNANCY AND IN POST-PARTUM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644281.

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Levels of total and free Protein S (PS) were measured on plasmas from 28 women during normal (n = 15, mean age = 25) and pathological pregnancy (Hypertension or preeclampsia, n = 13, mean age = 27). Prepartum (PreP) samples were obtained in the third trimester between the 30th and the 40th weeks of gestation, and postpartum (PostP) blood collected in the 5 days after delivery. Total PS level was determined using Laurel 1 rocket immunoelectrophoresis (Diagnostica Stago, Asnifcres-France). Free PS was measured using the same method after precipitation of C4b-BP-Bound-PS by polyethylene glycol. C4b-Binding Protein (C4b-BP) determinations were conducted by Laurel 1 method as well. Results were expressed as a percentage (Mean ± SD) of a normal adult pool (n = 15).A significant decrease of free PS level was observed both in normal or pathological pregnancy and in postpartum. These data might be explained, by the increase of C4b-BP plasmatic level.*= p&lt;0.05 (as compared to normal controls), **= p&lt;0.01, ***= p&lt;0.001 (Student´s t test).
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9

Blanco, Fernando F., Nicole C. Meisner-Kober, Eric Londin, et al. "Abstract A05: The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through post-transcriptional regulation of the serine-threonine kinase PIM1." In Abstracts: AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; June 18-21, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.pms14-a05.

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10

Pestell, RG, K. Chen, K. Wu, et al. "Abstract P5-11-04: Post-translational modification of the cell-fate factor Dachshund determines p53 binding and signaling modules in breast cancer." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p5-11-04.

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