Journal articles: 'Bini'

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Wester, Susan. "Barbara Bini: Archaeological Photographer." Visual Resources 5, no. 1 (1988): 33–40. http://dx.doi.org/10.1080/01973762.1988.9659155.

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Nurhasybi, NFN, and Tati Suharti. "Control of Seed-borne Disease (Octomeles Sumatrana) during Storage." Jurnal Perbenihan Tanaman Hutan 8, no. 2 (2020): 133–44. http://dx.doi.org/10.20886/bptpth.2020.8.2.133-144.

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The forest tree species that are widely grown to produce pulp and paper raw materials are Acacia spp. and Eucalyptus spp. One alternative species is binuang bini (Octomeles sumatrana) which can be developed for plantations. To maintain high seed viability, it is necessary to know the handling of seeds and control of seed-borne diseases during storage. The purpose of this study was to determine the method of the effective technique to control the seed-borne diseases of binuang bini during seed storage. The techniques for Seed disease kontrol methods in seed storage are carried out using chemical and natural fungicide. The results showed that the pure live seed was influenced by a single factor of fungicide and storage room, interactions between fungicides and storage room, interactions between fungicides and storage periods as well as interactions between fungicides and storage space and storage periods. Seed handling of binuang bini can be conducted effectively and efficiently by storing the seed in refrigerator for 3 months without using fungicides, but it will be better if the seed is given benomil fungicide and stored in airconditioned room (temperature of 18℃-20℃ and relative humidity of 50%-60 %).

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Cohen, Jonathan. "In Memoriam—Dr. Edmund J. Bini." Gastrointestinal Endoscopy 71, no. 7 (2010): 1113. http://dx.doi.org/10.1016/j.gie.2010.04.008.

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Nuraeni, Yeni, Illa Anggraeni, and Rina Bogidarmanti. "IDENTIFIKASI RAYAP BENUANG BINI (Octomeles sumatrana Miq) DI KHDTK HAURBENTES." JURNAL HUTAN PULAU-PULAU KECIL 1, no. 2 (2016): 92. http://dx.doi.org/10.30598/jhppk.2016.1.2.92.

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Benuang Bini Plant is one of alternative plant as raw material for the pulp industry. This species hasn’t been develoved extensively in the form forest plantation in Indonesia. Development activities in the form of pilot project has been developed by the Forestry Reseach and Development in KHDTK Haurbentes, West Java. In the benuang bini plant development, have various constraints such as pest and diseases attack. One of the pest that attack benuang bini plant in KHDTK Haurbentes is termite. The study was conducted in October 2014 in KHDTK Haurbentes, aims to identify the species of termites, knowing the percentage and observation of symptoms of termite attack. The study was conducted by survey method, sampling termites and termite species identication in the laboratory. The identication result termites that attack benuang bini is Microtermes sp. famili Termitidae. The percentage of attack are relatively low at 0,8 %. Termite control done by eradication and extermination from planting area.

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Lewis, Demola. "Linguistic Prehistory and Identity in Nigeria’s Bini-Ife Pre-eminence Contestation." Multilingual Margins: A journal of multilingualism from the periphery 5, no. 1 (2018): 2. http://dx.doi.org/10.14426/mm.v5i1.86.

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On the basis of genetic classification, Edoid (of the Bini people of Nigeria) is conceivedas an offshoot of Benue-Congo earlier than Yoruboid (of the Ife people of Nigeria).However, the reverse is the case when viewed from the sociolinguistic platforms ofpopulation, prestige and power. Thus, in 2004, the Edoid patriarch of Bini launcheda biography, wherein he narrated the Bini origin of the Ife monarchy. This sparked abarrage of unguarded responses from both sides of the controversy, largely centredon different interpretations to oral tradition. By exploring language as custodian ofprehistory, this paper makes a linguistic contribution to the continuing debate aboutwhich predates the other between Ife (Yoruboid) and Bini (Edoid) of southwesternNigeria. It pieces together evidence of cognate lexical simplification, patterns ofcognate counting systems, sound inventory, and decadence of vowel harmony, whichsupport the chronological pre-eminence of Edoid over Yoruboid; thus, calling forarchaeological, anthropological and geographical inspection.

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Bondarenko, Dmitri M. "Advent of the Second (Oba) Dynasty: Another Assessment of a Benin History Key Point." History in Africa 30 (2003): 63–85. http://dx.doi.org/10.1017/s0361541300003144.

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There is no other theme in precolonial Benin Kingdom studies around which so many lances have been broken as that of consolidation of the present-day Second (Oba) dynasty and the person of its founder Oranmiyan (Oranyan in Yoruba). The main reason for this is the existence of considerable disagreements between numerous Bini and Yoruba versions of the oral historical tradition. Besides this, the story of Oranmiyan is one of the Bini and Yoruba oral history pages most tightly connected with mythology. This fact becomes especially important if one takes into account that the oral tradition is no doubt the main (though not the only) source on the consolidation of the Oba Dynasty in Benin. The key point on which different Bini and Yoruba traditions openly contradict each other, and which scholars debate, is the origin of the Dynasty. Who initiated its founding: Bini or Yoruba? Was it a request or a conquest? Are the characters of the oral tradition relations historical figures? Finally, what were historical, sociocultural, and political circumstances of the Oba accession?If one disengages from details, three groups of traditional versions that describe the origin and life of Oranmiyan (including its period connected with Benin) can be distinguished. These groups may be designated as the Yoruba one, the Benin “official” (i.e., traditionally recognized by Oba themselves and most widely spread among common Bini) and Benin “apocryphal” traditions. In the meantime it should be borne in mind that Bini and Yoruba native gatherers and publishers of the oral historical tradition could influence each other. For example, the Yoruba Johnson could influence the Bini Egharevba, while the latter in his turn could influence another Yoruba, Fabunmi, and so on.

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Baidha, Wardatul. "IMPLEMENTASI HITUNG BINI PADA PEMBELAJARAN BERHITUNG DI KALANGAN WARGA KEAKSARAAN FUNGSIONAL BUDI MULIA DI DESA BAKAPAS KECAMATAN BARABAI." Khazanah: Jurnal Studi Islam dan Humaniora 13, no. 2 (2017): 195. http://dx.doi.org/10.18592/khazanah.v14i2.1669.

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Dalam mengembangkan kemajuan warga belajar, pendidikan kekasaraan fungsional sangat penting. Pendidikan keaksaraan fungsional adalah program pengembangan kemampuan seseorang dalam menguasai dan menggunakan keterampilan membaca, menulis dan menghitung. Salah satu kemampuan yang ingin dicapai dalam pendidikan keaksaraan fungsional adalah kemampuan berhitung dan dalam masyarakat Banjar ada salah satu cara berhitung cepat yang dinamakan Hitung Bini. Cara ini bisa diterapkan pada operasi hitung matematika seperti, penjumlahan, pegurangan, perkalian dan pembagian. Penelitian ini merupakan penelitian lapangan dengan pendekatan deskriptif kualitatif Subyek dalam penelitian ini adalah 1 tutor berhitung dan 20 warga belajar, sedangkan obyeknya adalah implementasi pendidikan keaksaraan fungsional Budi Mulia, implementasi Hitung Bini dan kendala-kendala dalam pengimplementasian Hitung Bini pada Pembelajaran berhitung di kalangan warga keaksaraan fungsional di Desa Bakapas Kecamatan Barabai. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Dari penelitian ini ditemukan bahwa proses pembelajaran berhitung di PKF Budi Mulia menggunakan hitungan tradisional yang dikenal dengan istilah Hitung Bini yang merupakan hitung kira-kira atau perkiraan. Kendala dalam pengimplementasiaan Hitung Bini, pertama kemampuan tutor dalam melaksanakan pembelajaran. Kedua, faktor usia dari warga belajar. Ketiga, daya pikir dan daya ingat dari para warga belajar yang berbeda-beda. Keempat, latar belakang sosial (pekerjaan) dari para warga belajar.

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Omotoso, D. R., A. J. Olanrewaju, U. C. Okwuonu, O. Adagboyin, and E. O. Bienonwu. "Morphometric study of cephalo-facial indices among Bini children in southern Nigeria." Anatomy Journal of Africa 8, no. 2 (2019): 1580–85. http://dx.doi.org/10.4314/aja.v8i2.189031.

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Cephalometry is an important branch of anthropometry which involves the morphological study of structures present in the human head or scientific measurement of the dimensions of the head. Some of the most important cephalometric parameters include the length/height and breadth/width of the head, the face and the nose as well as their respective indices. These cephalometric parameters are vital in the description of variation which is a common phenomenon that characterizes human physiognomy. They are also useful in the description of human inter-racial and intra-racial similarities both within and across gender. This study involved 450 Bini children (235 males and 215 females) between ages 5-12 years. The length and width of the head and face of each subject was measured between the appropriate anatomical landmarks using spreading and sliding calipers. The measurements were used to calculate the cephalic and facial indices for each subject. The result showed sexual variation in both cephalic and facial indices among the Bini children with the males having higher values than the females. Also, the result of this study showed that prevalence of brachycephalic head type among both male (51.1%) and female (49.8%) Bini children. The mesoproscopic face type was the most prevalent face type among both male (62.6%) and female (47.4%) Bini children. The cephalo-facial indices are vital in demonstrating similarity and variation in physical morphologies of individuals or group of people of different ethnicity, races, gender and geographical locations. Keywords: Cephalometry, Cephalic index, facial index, Bini children, Nigeria

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Omotoso, D. R., A. J. Olanrewaju, U. C. Okwuonu, O. Adagboyin, and E. O. Bienonwu. "Retracted: Morphometric study of cephalo-facial indices among Bini children in southern Nigeria." Anatomy Journal of Africa 8, no. 2 (2019): 1552–57. http://dx.doi.org/10.4314/aja.v8i2.188222.

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This article has been retracted by the Editor.Cephalometry is an important branch of anthropometry which involves the morphological study of structures present in the human head or scientific measurement of the dimensions of the head. Some of the most important cephalometric parameters include the length/height and breadth/width of the head, the face and the nose as well as their respective indices. These cephalometric parameters are vital in the description of variation which is a common phenomenon that characterizes human physiognomy. They are also useful in the description of human inter-racial and intra-racial similarities both within and across gender. This study involved 450 Bini children (235 males and 215 females) between ages 5-12 years. The length and width of the head and face of each subject was measured between the appropriate anatomical landmarks using spreading and sliding calipers. The measurements were used to calculate the cephalic and facial indices for each subject. The result showed sexual variation in both cephalic and facial indices among the Bini children with the males having higher values than the females. Also, the result of this study showed that prevalence of brachycephalic head type among both male (51.1%) and female (49.8%) Bini children. The mesoproscopic face type was the most prevalent face type among both male (62.6%) and female (47.4%) Bini children. The cephalo-facial indices are vital in demonstrating similarity and variation in physical morphologies of individuals or group of people of different ethnicity, races, gender and geographical locations.Keywords: Cephalometry, Cephalic index, facial index, Bini children, Nigeria

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10

Saleh, Raja. "BENTUK SAPAAN KEKERABATAN DALAM BAHASA BANJAR DI TEMBILAHAN, RIAU." Madah: Jurnal Bahasa dan Sastra 8, no. 1 (2017): 19. http://dx.doi.org/10.31503/madah.v8i1.471.

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Penelitian ini bertujuan untuk mendeskripsikan bentuk sapaan kekerabatan yang digunakan dalam bahasa Banjar di Tembilahan, Riau. Metode yang dugunakan dalam penelitian ini adalah metode deskriptif kualitatif. Data dikumpulkan melalaui teknik wawancara dan catat. Teknik analisis data yang digunakan adalah metode padan, dengan langkah-langkah mengklasifikasikan data menurut jenisnya, mendeskripsikan masing-masing sapaan, dan pemberian contoh sapaan (pemadanan) dalam kalimat. Hasil penelitian ini menunjukkan bentuk kata sapaan berdasarkan garis keturunan adalah abah, uwak laki, uwak bini, nanang, acik, abang, kakak, ading, anak, cucu, nenek laki, dan datuk. Sedangkan bentuk kata sapaan kekerabatan berdasarkan garis perkawinan adalah umak, abah mintuhak, umak mintuhak, nenek bini, nenek laki, nanang, acik, ulak, uwak, mantu, bini, laki, kakak ipar, abang ipar, dan ading ipar. Penelitian ini menyimpulkan ada dua bentuk sapaan kekerabatan dalam bahasa Banjar di Tembilahan, Riau, yaitu bentuk kata sapaan kekerabatan berdasarkan garis keturunan dan bentuk kata sapaan kekerabatan berdasarkan garis perkawinan.

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Eboh, D. E. O. "Nasal Indices among Bini Adolescents in Edo State, Nigeria." International Journal of Morphology 29, no. 4 (2011): 1231–34. http://dx.doi.org/10.4067/s0717-95022011000400027.

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12

Lang, Les. "Editorial Board Member Dr. Edmund J. Bini (1967–2010)." Gastroenterology 139, no. 1 (2010): 5–6. http://dx.doi.org/10.1053/j.gastro.2010.05.011.

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BEST, JAN. "THE MANY FACES OF JABU-RE AND BINI-RE." Kadmos 42, Jahresband (2003): 39–46. http://dx.doi.org/10.1515/kadm.2003.42.1.39.

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Dereli, Tekin. "Giorgio Ferrarese, Donato Bini: Introduction to relativistic continuum mechanics." General Relativity and Gravitation 41, no. 2 (2008): 449–50. http://dx.doi.org/10.1007/s10714-008-0729-y.

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15

Bräu, Norbert. "In Memoriam: Edmund J. Bini, MD, MPH (1967–2010)." Digestive Diseases and Sciences 55, no. 5 (2010): 1193. http://dx.doi.org/10.1007/s10620-010-1224-3.

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Bendell, Johanna C., Scott Kopetz, Mark R. Middleton, et al. "Phase 1b/2 study of binimetinib (BINI) in combination with nivolumab (NIVO) or NIVO plus ipilimumab (IPI) in patients (pts) with previously treated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) with RAS mutation." Journal of Clinical Oncology 36, no. 4_suppl (2018): TPS870. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.tps870.

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TPS870 Background: Approximately 96% of CRCs have an MSS phenotype, which results in more immunologically quiescent tumors for which immunotherapies are largely ineffective (Lee et al. 2015; Overman et al. 2016). Pts with MSS CRC and activating RAS mutation (35%–45% of CRCs) have treatment options limited still further because anti-EGFR monoclonal antibodies (eg, cetuximab) are ineffective owing to dominant activation of RAS in the MAPK pathway (Douillard et al. 2014). However, preclinical and preliminary clinical data suggest that MAPK pathway inhibition enhances antigen presentation and T-cell cytotoxicity to positively modulate the efficacy of checkpoint inhibitors (Brea et al. 2016; Bendell et al. 2014). The main objective of this open-label multicenter phase 1b/2 study is to evaluate whether the potential positive modulation of NIVO or NIVO plus IPI, when combined with BINI, translates into clinically meaningful overall response in pts with MSS mCRC and RAS mutation. Methods: The study will enroll ~90 previously treated pts (1 or 2 prior regimens), ~42 in phase 1b and ~48 in phase 2. The primary objective of phase 1b will be to determine the recommended phase 2 dose (RP2D) of BINI in combination with NIVO ± IPI. Dose finding in the doublet arm will begin with BINI 45 mg BID + NIVO 480 mg Q4W; the triplet arm will begin with the BINI RP2D from the doublet arm + NIVO 480 mg Q4W + IPI 1 mg/kg Q8W. In phase 2, pts will be randomized 1:1 to doublet or triplet arms, incorporating the BINI RP2Ds found in phase 1b; treatment will continue in 28-day cycles until disease progression, unacceptable toxicity, withdrawal of consent, initiation of subsequent anticancer therapy, loss to follow-up, or death. The primary objective for phase 2 will be to assess response by RECIST version 1.1. The study will also characterize safety and PK. CT.gov Identifier: Clinical trial information: NCT03271047.

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Ruck, Michael. "Die Kristallstruktur von BiNi: eine komplexe Ausdünnungsvariante des InNi2-Typs." Zeitschrift für anorganische und allgemeine Chemie 625, no. 12 (1999): 2050–54. http://dx.doi.org/10.1002/(sici)1521-3749(199912)625:12<2050::aid-zaac2050>3.0.co;2-r.

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Лёкина, Ю. О., Я. С. Глазкова, А. А. Белик, И. А. Пресняков та А. В. Соболев. "Зондовое мессбауэровское исследование BiNi 0.96 57 Fe 0.04 O 3". Неорганические материалы 54, № 10 (2018): 1046–54. http://dx.doi.org/10.1134/s0002337x18100123.

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Rotimi, Omotoso Dayo, Baxter-Grillo Dorothea, Adagboyin Osa, and Bienonwu Emmanuel. "COMPARATIVE ASSESSMENT OF CEPHALIC INDEX AMONG BINI AND IGBO TRIBES IN BENIN CITY, NIGERIA." International Journal of Anatomy and Research 7, no. 2.3 (2019): 6685–89. http://dx.doi.org/10.16965/ijar.2019.208.

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Kania, P. W., H. Taraschewski, Y. S. Han, D. K. Cone, and K. Buchmann. "Divergence between Asian, European and Canadian populations of the monogenean Pseudodactylogyrus bini indicated by ribosomal DNA patterns." Journal of Helminthology 84, no. 4 (2010): 404–9. http://dx.doi.org/10.1017/s0022149x10000088.

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AbstractThe monogenean Pseudodactylogyrus bini parasitizes the gills of eels belonging to the genus Anguilla. Circumstantial evidence suggests that the parasite has been spread accidentally from the Pacific area (East Asia) to Europe by the intercontinental eel trade. This is based on early descriptions of the parasites from Asian regions and the lack of records of the parasites in Europe before 1977. In addition, the susceptibility of European eels to infections with the parasite is significantly higher compared to that of Japanese eels, which could indicate that the European eel had not undergone co-evolution with this parasite. The present study was undertaken to elucidate the origin of the parasite by using molecular tools. Parasite samples were obtained from Europe (Germany), Asia (Taiwan) and Nova Scotia, the latter of which is the first record of P. bini in Canada. Sequencing of rDNA comprising part of the internal transcribed spacer 1 (ITS1) gene, 5.8S and part of ITS2 (1323 bp) showed that P. bini isolates from the first two regions showed high variability. One sequence was found both in a number of Asian parasites and with one to a few transitions in European parasites, which could indicate that they were split recently into the two regions. Other sequence variations suggested that one or a few genotypes of P. bini were imported on one occasion from Asia to Europe and that the two geographic isolates subsequently developed differently in the two regions. The Nova Scotian/Canadian isolates showed no variation and were found to be unique compared to the European and Taiwanese forms, indicating that this population is independent in origin. This could indicate that the Canadian parasites were introduced to North America on another occasion and independently of the European colonization.

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Dummer, Reinhard, Shahneen Kaur Sandhu, Wilson H. Miller, et al. "A phase II, multicenter study of encorafenib/binimetinib followed by a rational triple-combination after progression in patients with advanced BRAF V600-mutated melanoma (LOGIC2)." Journal of Clinical Oncology 38, no. 15_suppl (2020): 10022. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.10022.

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10022 Background: LOGIC2 evaluates the benefit of a 3rd agent added to encorafenib (enco)/binimetinib (bini), selected at progression based on the genetic tumor evolution. Methods: In part I/run-In, pts were treated with enco/bini until disease progression (as defined per RECIST v1.1). Foundation One NGS was applied on a baseline sample and on a PD sample. Based on the genetic evolution between the biopsy at inclusion (bxI) and at progression (bxPD) and clinical considerations, pts entered part II and received one of four 3rd agent additions to enco/bini combinations: A. LEE011 (CDK4/6 inhibitor), B. BKM120 (PI3K inhibitor), C. INC280 (c-Met inhibitor), or D. BGJ398 (FGFR inhibitor). An adaptive Bayesian logistic regression model (BLRM) guided by the escalation with overdose control (EWOC) principle was used to make dose escalation decisions. Assessments include objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and safety. Data cutoff for this analysis was May 12, 2019. Data is as is. Part 1 of study is ongoing. Part 2 of study is closed to enrollment. Results: 58 pts enrolled into part II (group A=38; B=6; C=13; D=1). 29 pts were assigned to treatment based on bxPD results (Table). In groups A, B, and C, the confirmed ORR was 5.3%, 0%, and 0%, and the DCR was 26.3%, 16.7%, and 15.4%, with median PFS of 2.1, 1.6, and 2.2 months, respectively. Safety was consistent with known profiles of the individual agents. Conclusions: Triple therapy is feasible when a 3rd agent is added to enco/bini at progression based on genetic alterations, although activity observed was low. Further exploration to identify patterns of resistance susceptible to the addition of a 3rd agent is needed. Gene alterations for enrollment into part 2. Clinical trial information: NCT02159066. [Table: see text]

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Aruta, Alessandro. "Shocking Waves at the Museum: The Bini–Cerletti Electro-shock Apparatus." Medical History 55, no. 3 (2011): 407–12. http://dx.doi.org/10.1017/s0025727300005482.

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The historian of science, Lorraine Daston, has written about things that talk. But how much can an artefact in a museum communicate its history to the public? Artefacts in museums speak, but it is not necessarily, or even at all, in the language of their original time and place. Cultural baggage, memories, and imagination all come into play, including those held by museum curators, and not least those contained within the operational and historical frameworks of such institutions. At the Museo di Storia della Medicina della Sapienza at the University of Rome we are organising an exhibition around an artefact that more than any other elicits emotive reactions – the Bini–Cerletti apparatus for the administration of electro-shock. This prototype of the first ECT machine, along with various historical documents, manuals, and textbooks relating to it, is a valued part of the Museo's collection. We are proud of it, yet as a display item, it is also something of golden chalice. Leaving aside the ethical question of whether we can (or should) convey to visitors the anxiety and pain of the patients who once submitted to the device, and leaving aside the different loads of historical and contemporary baggage that visitors will bring to it, how can such an object be represented in an historically honest way? This is the problem, for while we might be true to the context of its emergence, within that context (of Fascist Italy) the Bini–Cerletti apparatus was at one and the same time a blessing, a hope, a lie, and a profitable commercial product.

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Marie, Sieliechi Joseph, Dangwang Dikdim Jean-Marie, and Noumi Guy Bertrand. "Speciation of phosphorus in the sediments of Lake Bini (Ngaoundere-Cameroon)." Environmental Technology 35, no. 14 (2014): 1831–39. http://dx.doi.org/10.1080/09593330.2014.884171.

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Buchmann, Kurt. "The Effects of Praziquantel on the Monogenean Gill Parasite Pseudodactylogyrus Bini." Acta Veterinaria Scandinavica 28, no. 3-4 (1987): 447–50. http://dx.doi.org/10.1186/bf03548614.

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Breathnach, C. S. "Cerletti." Irish Journal of Psychological Medicine 7, no. 2 (1990): 177. http://dx.doi.org/10.1017/s0790966700016839.

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Abstract:Electroconvulsive therapy was introduced in 1938 by Ugo Cerletti (1877-1963) of Rome in association with “young Dr. Bini”. Cerletti's training and his development of the electrical technique as an alternative to chemically-induced convulsions are briefly outlined.

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Rotimi, Omotoso Dayo, Adagbonyin Osahenrhumwen, Bienonwu Emmanuel, and Uwagbor Victor. "ANTHROPOMETRIC EVALUATION OF NASAL HEIGHT, NASAL BREADTH AND NASAL INDEX AMONG BINI CHILDREN IN SOUTHERN NIGERIA." International Journal of Anatomy and Research 7, no. 3.2 (2019): 6896–900. http://dx.doi.org/10.16965/ijar.2019.255.

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Ascierto, Paolo Antonio, Oliver Bechter, Pascal Wolter, et al. "A phase Ib/II dose-escalation study evaluating triple combination therapy with a BRAF (encorafenib), MEK (binimetinib), and CDK 4/6 (ribociclib) inhibitor in patients (Pts) with BRAF V600-mutant solid tumors and melanoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 9518. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.9518.

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9518 Background: The benefits of BRAF + MEK inhibition (dual combo) in pts with BRAF V600-mutant ( BRAFV600) melanoma are known. Preclinical data supports inhibiting CDK 4/6 and BRAF + MEK (triple combo) to improve antitumor activity. We report safety and preliminary efficacy from a phase 1b/2 study (NCT01543698) of encorafenib (ENCO; a selective BRAF kinase inhibitor), binimetinib (BINI; a MEK inhibitor), and ribociclib (RIBO; a CDK 4/6 inhibitor). Methods: Phase 1b of this open-label, multicenter study enrolled pts with confirmed BRAFV600advanced solid tumors. Escalating doses of RIBO 100 mg-600 mg QD for 3 wk on/1 wk off were administered with ENCO 200 mg QD + BINI 45 mg BID in successive cohorts (6 pts each) until the maximum tolerated or recommended phase 2 dose (RP2D) was reached. Due to potential pharmacokinetic interactions with RIBO, the ENCO dose was lower than the dual combo RP2D (450 mg QD). Dose escalations followed an adaptive Bayesian model. In phase 2, the triple combo was tested in pts with BRAFV600melanoma naïve to prior BRAF inhibitor treatment; the primary endpoint was objective response rate (ORR) per RECIST v1.1. Results: In phase 1b (n = 21), no dose-limiting toxicities were reported and the triple combo RP2D was ENCO 200 mg QD + BINI 45 mg BID + RIBO 600 mg QD. ENCO AUC was slightly lower than at the dual combo RP2D. In phase 2 (n = 42), 59.5% pts had an ECOG PS of 0 and 43% of pts had elevated lactate dehydrogenase. The most common (≥5%) grade 3/4 toxicities were neutropenia (26.2%), increased alanine transaminase (14.3%), diarrhea (7.1%), and anemia (7.1%). Ten pts (23.8%) discontinued treatment due to an AE, of which 4 were increased transaminases. The confirmed ORR was 52.4%, including 4 complete responses, 18 partial responses, and 15 pts with stable disease. Median duration of exposure in phase 2 was 9.1 mo (range, 0.0-21.6). Median progression-free survival was 9.0 mo (95% confidence interval, 7.0-11.1). Conclusions: Triple therapy with ENCO + BINI + RIBO in this small trial of pts with high disease burden was associated with responses in over half of pts and some evidence of increased toxicity. Clinical trial information: NCT01543698.

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Schuler, Martin H., Paolo A. Ascierto, Filip Yves Francine Leon De Vos, et al. "Phase 1b/2 trial of ribociclib+binimetinib in metastatic NRAS-mutant melanoma: Safety, efficacy, and recommended phase 2 dose (RP2D)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 9519. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.9519.

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9519 Background: Simultaneous inhibition of MEK and CDK4/6 may suppress MAPK pathway activation and cell-cycle checkpoint dysregulation in NRAS-mutant melanoma, resulting in enhanced antitumor activity. Phase 1b data are reported. Methods: The phase 1b primary objective was to determine maximum tolerated dose (MTD)/RP2D. A 28-d cycle of oral ribociclib (RIBO) once daily (QD) for 21 d + oral binimetinib (BINI) twice daily (BID) for 28 d, and a 21-d cycle of RIBO QD + BINI BID, both for 14 d per cycle, were evaluated. Secondary objectives were to evaluate efficacy, safety and pharmacodynamics. Results: Based on dose escalation (van Herpen, ESMO 2015), MTD was 600mg RIBO/45mg BINI for the 21-d and 200/45 for the 28-d regimens. Due to promising activity, the 28-d cycle was selected as RP2D(unconfirmed partial response [PR] with limited follow-up occurred in 35% of pts). This finding was supported by comparable and manageable safety and the Bayesian logistic regression model.As of Jan 2017, the RP2D was received by 16 pts in phase 1b (ECOG PS 0/1/2, 63%/31%/6%; elevated lactate dehydrogenase, 44%; stage IVM1c disease, 50%; prior ipilimumab [ipi], 44%; prior anti–programmed death [PD]-1/PD-L1, 31%). Median (range) exposure was 4 (0–13) mo. Common adverse events (AEs) were increased blood creatine phosphokinase, elevated AST, peripheral edema, acneiform dermatitis, diarrhea and fatigue. Common grade 3/4 AEs were elevated AST and ALT (19%/6%), nausea (19%/0%), rash (19%/0%), vomiting (6%/6%) and neutropenia (12%/0%). Confirmed PR (cPR) occurred in 4 pts (25%; time to response, 48–168 d), stable disease in 7 pts (44%), disease progression in 3 pts (19%); 2 pts (12%) were not evaluable. Among cPR pts, 3 had prior ipi and/or anti–PD-1/PD-L1. Median progression-free survival (mPFS) was 6.7 (95% CI, 3.5–9.2) mo. Sequence analysis of synchronous non- RAS genetic alterations will be presented. Conclusions: Combined RIBO/BINI at the selected RP2D had a manageable safety profile and favorable efficacy (based on mPFS) for NRAS-mutant melanoma in phase 1b. Based on these promising data, the phase 2 expansion is underway to assess antitumor activity at the RP2D. Clinical trial information: NCT01781572.

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Metastasio, Antonio, and David Dodwell. "A translation of "L´Elettroshock" by Cerletti & Bini, with an introduction." European Journal of Psychiatry 27, no. 4 (2013): 231–39. http://dx.doi.org/10.4321/s0213-61632013000400001.

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Buchmann, K., and P. Prento. "Cholinergic and aminergic elements in the nervous system of Pseudodactylogyrus bini (Monogenea)." Diseases of Aquatic Organisms 6 (1989): 89–92. http://dx.doi.org/10.3354/dao006089.

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Chi, Ping, Li-Xuan Qin, Ciara Marie Kelly, et al. "A phase II study of MEK162 (binimetinib [BINI]) in combination with imatinib in patients with untreated advanced gastrointestinal stromal tumor (GIST)." Journal of Clinical Oncology 38, no. 15_suppl (2020): 11508. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.11508.

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11508 Background: ETV1 and KIT are lineage-specific master transcriptional and signaling survival factors in GIST. In preclinical models, dual lineage targeting of ETV1 by MEK inhibition with BINI and KIT by imatinib are synergistic in suppressing GIST tumorigenesis and progression. This single-arm phase II study is designed to test the efficacy of the BINI+imatinib as a first-line treatment in patients (pts) with advanced GIST. Methods: Adult pts with untreated advanced GIST received imatinib (400mg daily) plus BINI (30mg twice daily), 28-day cycles. The primary endpoint (EP) was RECIST1.1 objective response rate (ORR) (complete response [CR]+partial response [PR]). The study was designed to detect a 20% improvement in the ORR of imatinib alone (unacceptable rate of 45%; acceptable rate of 65%). A sample size of 44 patients was required, using an exact binomial test, one-sided type I error of 0.08 and type II error of 0.1. Confirmed PR in > 24 pts would be considered positive. Secondary EPs included RR by Choi and EORTC criteria, resectability conversion rate (RCR), progression free survival (PFS), overall survival (OS) and long-term AEs. Correlatives included characterization of tumor genomics by MSK-IMPACT, cfDNA by MSK-ACCESS, ETV1 protein levels and transcriptomes and signaling inhibition. Results: At data cutoff of Jan 31, 2020, 38/39 pts with advanced GIST of all genotypes, including 3 KIT/PDGFRA-wild type GIST pts, were evaluable for primary EP. Median age 60 (range 29-78), 29% female. 26/38 pts with confirmed PR; Best ORR was 68.4% (two-sided 95% CI, 51-83%; one-sided 90% CI, 57-100%). 8/9 pts became resectable after treatment; RCR was 88.9% (95% CI, 52-100%). 13 pts remain on trial (2-159 weeks [wks]). 9 pts discontinued trial due to disease progression (11-159 wks); one pt progressed within 3 months, indicating primary resistance. Grade 3/4 toxicity included CPK elevation (asymptomatic, 61%), neutrophil decrease (11%), maculopapular rash (8%), anemia (8%). No unexpected toxicities observed. Correlation of outcome with MSK-IMPACT, MSK-Access and paired tumor biopsies will be presented. Conclusions: This study met its primary endpoint. BINI plus imatinib is highly effective in treatment-naive advanced GIST, with expected and manageable long-term treatment-associated toxicities. The combination strategy warrants further evaluation in direct comparison with imatinib in the frontline treatment of GIST. Clinical trial information: NCT01991379 .

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Lim, Yongdo. "Stopping criteria for the Ando–Li–Mathias and Bini–Meini–Poloni geometric means." Linear Algebra and its Applications 434, no. 8 (2011): 1884–92. http://dx.doi.org/10.1016/j.laa.2010.12.013.

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Eberly, Wayne. "Polynomial and Matrix Computations Volume 1: Fundamental Algorithms (Dario Bini and Victor Pan)." SIAM Review 38, no. 1 (1996): 161–65. http://dx.doi.org/10.1137/1038020.

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Huijberts, Sanne, Jan H. M. Schellens, Marwan Fakih, et al. "BEACON CRC (binimetinib [BINI], encorafenib [ENCO], and cetuximab [CTX] combined to treat BRAF-mutant metastatic colorectal cancer [mCRC]): A multicenter, randomized, open-label, three-arm phase III study of ENCO plus CTX plus or minus BINI vs irinotecan (IRI)/CTX or infusional 5-fluorouracil/folinic acid/IRI (FOLFIRI)/CTX with a safety lead-in of ENCO + BINI + CTX in patients (Pts) with BRAFV600E mCRC." Journal of Clinical Oncology 35, no. 15_suppl (2017): TPS3622. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.tps3622.

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TPS3622 Background: BRAF mutations are found in ≈10% of mCRC cases. Pts with BRAFV600E mCRC have a poor prognosis, with shorter progression-free survival (PFS) and overall survival (OS) than pts with BRAFwt mCRC (Van Cutsem et al 2011; Modest et al 2012; Sorbye et al 2015). The benefits of combined BRAF + EGFR inhibition in mCRC have been demonstrated in vitro (Corcoran et al 2012; Prahallad et al 2012; Yang et al 2012), and preclinical evidence suggests that adding MEK signaling inhibition improves antitumor activity. Early clinical data indicate that BRAF + EGFR + MEK inhibition has greater activity than BRAF + EGFR inhibition in pts with BRAFV600E mCRC (Van Cutsem et al 2016). Our study will examine the combination of BINI (a MEK inhibitor) + ENCO (a selective BRAF kinase inhibitor) + CTX (an anti-EGFR antibody) and of ENCO + CTX in pts with BRAFV600E mCRC. Methods: BEACON CRC (NCT02928224) is enrolling pts with BRAFV600E mCRC whose disease has progressed after 1 or 2 prior regimens in the metastatic setting. A safety lead-in phase (≈30 pts) will determine the safety and tolerability of oral ENCO 300 mg QD + oral BINI 45 mg BID + intravenous CTX 400 mg/m2 followed by 250 mg/m2 QW. In the phase 3 portion, ≈615 pts will be randomized 1:1:1 to triplet (ENCO + BINI + CTX), doublet (ENCO + CTX), or control (investigator’s choice of IRI/CTX or FOLFIRI/CTX) arms. Pts will be treated in 28-day cycles until disease progression, unacceptable toxicity, withdrawal of consent, initiation of subsequent anticancer therapy, or death. The primary endpoint is OS (triplet vs control). Secondary endpoints include OS (doublet vs control), confirmed investigator-assessed objective response rate according to RECIST version 1.1 (triplet or doublet vs control; triplet vs doublet), PFS (triplet or doublet vs control), duration of response, time to response, pharmacokinetics, and pt-reported outcomes. Safety will be summarized using standard adverse event reporting. Clinical trial information: NCT02928224.

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Bini, Valerio. "Politiques sanitaires et ségrégation urbaine dans les villes africaines: de la peur de l’épidémie à l’épidémie de la peur." Ponts-Ponti: Langues littératures civilisations des Pays francophones, no. 13 (November 2013): 35–42. http://dx.doi.org/10.7358/pont-2013-013-bini.

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Ban, Gaofang, Fenglian Sun, Yang Liu, and Shaonan Cong. "Effect of nano-Cu addition on microstructure evolution of Sn0.7Ag0.5Cu-BiNi/Cu solder joint." Soldering & Surface Mount Technology 29, no. 2 (2017): 92–98. http://dx.doi.org/10.1108/ssmt-06-2016-0013.

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Purpose The purpose of this paper is to focus on the fabrication of SnAgCu (SAC) nanocomposites solder and study the effect of Cu nanopowders (nano-Cu) addition on the microstructure evolution of resultant nanocomposite solder after reflow and thermal aging. Design/methodology/approach Mechanical mixing is used in this work to incorporate nanoparticles into the solder and produce more homogeneous mixture. Standard metallographic procedures are applied for microstructural analysis of solder joints. Findings It is found that nano-Cu doped into Sn0.7Ag0.5Cu-BiNi solder has no appreciable influence on melting temperature of the composite solder. The addition of Cu nanoparticles refines the microstructure of bulk solder and suppresses the growth of interfacial intermetallic compound (IMC) layers. However, interfacial IMC grain size increases slightly after 1.0 per cent nano-Cu added. Originality/value The paper demonstrates a method of nano-composite solder paste preparation by means of mechanical mixing and a comparison study of the microstructure evolution of composite solder with the basic SAC solder.

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Liu, Yang, Fenglian Sun, Hongwu Zhang, and Pengfei Zou. "Solderability, IMC evolution, and shear behavior of low-Ag Sn0.7Ag0.5Cu-BiNi/Cu solder joint." Journal of Materials Science: Materials in Electronics 23, no. 9 (2012): 1705–10. http://dx.doi.org/10.1007/s10854-012-0649-1.

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Buchmann, K. "Temperature-dependent reproduction and survival ofPseudodactylogyrus bini (Monogenea) on the European eel (Anguilla anguilla)." Parasitology Research 75, no. 2 (1988): 162–64. http://dx.doi.org/10.1007/bf00932717.

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Shishelov, Nikita S. "BINI THE PROPHET AND RELIGIOUS FEVER AMONG THE CARRIER INDIANS IN 1834 - THE 1840S." Study of Religion, no. 1 (2018): 71–83. http://dx.doi.org/10.22250/2072-8662.2018.1.71-83.

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The article deals with the phenomenon of religious fever among the indigenous people of central British Columbia in the second quarter of the 19th century. In a short time, the traditional belief system of the Carrier Indians adopted some of the Christian doctrines and symbolism. This took place in the period before the first missionaries came to the region. Paradoxically, at the initial stage, the enculturation of Christianity started without participation of Christians themselves. The transformation of the Indians’ religious views wasn’t accompanied by European cultural expansion. In the late 1860s, when the missionaries started their active agency, the Indians were ready to accept the new religion without resistance. This article is based on the analysis of folk tales, historical dates and researches devoted to this subject. The channels of cultural diffusion and the integration of elements of Christianity into traditional beliefs are revealed. The psychological reasons of acceptance of the new religion by the Indians are also in the focus of attention. The author determines the date of the beginning of the Prophet's movement among the Carrier. The key source of this dating was John McLean's journal, which has not previously been used in researches of the subjects. The author proposes accounting this cultural phenomenon as a spontaneous movement, not a cult of a religious leader.

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Okunola, Rashidi Akanji, and Adediran Daniel Ikuomola. "Festival of Curses: A Traditional Crime Control Method In Edo State –Nigeria." Issues in Ethnology and Anthropology 7, no. 1 (2016): 85–106. http://dx.doi.org/10.21301/eap.v7i1.4.

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Festivals and ceremonies are part and parcel of African culture, usually in all its pump, merriment and pageantry. However, with the increasing wave of criminal activities in Nigeria especially in Edo state, festivals and ceremonies are being redefined and conceptualized in practice. Only recently a new festival ‘Festival of Curses’ was brought to the fore in combating crime in Edo state. The study therefore seeks to explain the festival as a traditional mechanism in crime control, the nature of the festival, the factors that led to its emergence in the 21st century, the level of acceptance and its impact in reducing criminal activities in the State. The study employed principally secondary literature and in-depth interviews among a cross section of the Bini. Major findings revealed that immediately after the festival of curses, a lot of criminals in the state besieged the Bini Monarch’s Palace to confess their atrocities; and pleaded for forgiveness. There was an overwhelming acceptance of the festival irrespective of the people’s religious affiliations to Christianity and Islam as a result of the potency and sudden drop in crime during the period. The study concludes that the festival should be taken as a mechanism of crime control and policing in Nigeria.

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Kopetz, Scott, Axel Grothey, Rona Yaeger, et al. "Updated results of the BEACON CRC safety lead-in: Encorafenib (ENCO) + binimetinib (BINI) + cetuximab (CETUX) for BRAFV600E-mutant metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 37, no. 4_suppl (2019): 688. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.688.

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688 Background: BRAFV600E mutation occurs in 10%-15% of patients (pts) with mCRC and confers a poor prognosis. After first-line therapy, standard second-line therapies provide limited benefit, with objective response rates (ORRs) < 10%, and overall survival (OS) of 46 months (mo). BEACON CRC (NCT02928224) is a 3-arm phase 3 trial of triplet therapy with the BRAF inhibitor ENCO + MEK inhibitor BINI + antiEGFR antibody CETUX vs ENCO + CETUX vs a control arm (irinotecan/FOLFIRI + CETUX) in pts with BRAFV600E mCRC in the second or third-line setting. A safety lead-in (SLI) of the triplet therapy was conducted in 30 pts prior to initiation of the randomized part of the trial. Previously reported confirmed ORR in 29 pts with BRAFV600E mCRC was 48% and median progression-free survival (PFS) was 8.0 mo (Van Cutsem E, et al. Ann Oncol. 2018;29:O-027). Here we present updated safety and efficacy results including mature OS. Methods: All pts in the SLI received ENCO 300 mg once daily + BINI 45 mg twice daily + CETUX standard weekly dose. Assessments included efficacy (ORR, duration of response, time to response, PFS, and OS), safety, and tolerability. Results: Among 30 pts treated, 1 had a BRAF non-V600E mutation and is not included in the efficacy analyses. At data cutoff, the median follow-up time for survival was 18.2 mo and median exposure was 7.8 mo (range 0.521.4 mo). The confirmed ORR and median PFS remain unchanged from the previous report (ORR, 48% [95%CI, 29.467.5]; PFS, 8.0 mo [95% CI, 5.69.3 mo]). Mature median OS is 15.3 mo (95% CI, 9.6 monot reached). The triplet continues to be well-tolerated with no unexpected toxicities. The most common grade 3/4 toxicities were fatigue (13%), anemia, increases in creatine phosphokinase and/or aspartate aminotransferase, and urinary tract infections (each 10%). The rate of grade 3/4 skin toxicities continues to be lower than generally observed with CETUX in mCRC. Conclusions: With longer follow-up, triplet therapy with ENCO + BINI + CETUX continues to be well tolerated. Median PFS and now mature median OS are substantially improved over historical data for current standard-of-care options. Clinical trial information: NCT02928224.

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Ezeuko, VitalisC, and PaulO Eboigbe. "Angular photogrammetric analysis of the facial profile of the adults of Bini ethnicity of Nigeria." Annals of Bioanthropology 3, no. 1 (2015): 14. http://dx.doi.org/10.4103/2315-7992.160737.

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Ogunduyileabimbola, Ogunduyileabimbola. "Gestures, Dance and Colour: Non-Lingusitic Communication in Emobo and Ewere Celebrations in Bini Kingdom." International Journal of English and Literature 7, no. 4 (2017): 187–96. http://dx.doi.org/10.24247/ijelaug201725.

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Ruck, Michael. "ChemInform Abstract: The Crystal Structure of BiNi: A Complex Superstructure of the InNi2 Structure Type." ChemInform 31, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.200012004.

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Ban, G. F., F. L. Sun, J. J. Fan, Y. Liu, and S. N. Cong. "Influence of Cu Nanoparticles on Microstructure and Mechanical Properties of Sn0.7Ag0.5Cu-BiNi/Cu Solder Joint." Journal of Materials Engineering and Performance 26, no. 3 (2017): 1069–75. http://dx.doi.org/10.1007/s11665-017-2528-7.

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Bini, Dante N., and Stefano Pietrogrande. "Self-Shaping Space Structures." International Journal of Space Structures 4, no. 2 (1989): 67–80. http://dx.doi.org/10.1177/026635118900400201.

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This paper describes the evolution of an innovative concept devised by Dante Bini in the early Sixties and later developed in a series of construction systems. This concept is based on the use of air pressure as a source of power for developing an automatic building process. The idea has further developed into a series of technologies based on the use of energy stored within various components of a self-shaping structure. These concepts may represent a first step toward “Auto-construction”.

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Van Cutsem, Eric, Pieter-Jan Cuyle, Sanne Huijberts, et al. "BEACON CRC study safety lead-in (SLI) in patients with BRAFV600E metastatic colorectal cancer (mCRC): Efficacy and tumor markers." Journal of Clinical Oncology 36, no. 4_suppl (2018): 627. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.627.

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627 Background: The SLI of the BEACON CRC phase 3 study assessed the safety and efficacy of the combination of the BRAF inhibitor encorafenib (ENCO) + MEK inhibitor binimetinib (BINI) + anti-EGFR antibody cetuximab (CETUX) in pts with BRAFV600E-mutant mCRC after 1 or 2 prior regimens. CEA and CA19-9 are tumor markers that are widely used to monitor the effectiveness of systemic therapies for mCRC; here we report on the association of CEA and CA19-9 changes while on treatment with clinical outcomes in pts from the SLI. Methods: Pts in the SLI received the triplet of ENCO 300 mg QD + BINI 45 mg BID + CETUX 400 mg/m2 (initial dose) then 250 mg/m2 QW in 28-day cycles. Pts were evaluated for safety, radiographic response, and change in tumor markers CEA and CA19-9. Results: 30 pts were treated. The triplet was generally well tolerated, and adverse events were consistent with known BRAF, MEK, and EGFR inhibitor toxicities. The rate of severe skin toxicities (grade 3/4) was lower than generally observed for CETUX in mCRC. Of the 29 pts with a BRAFV600E mutation, the median time on study treatment was 5.6 mo (range, 1.0–9.3 mo), and 22 (76%) remained on study treatment at the time of data cutoff. The confirmed overall response rate (ORR) was 41%, with 1 complete and 11 partial responses. In addition, 9 pts had prolonged stable disease (SD) up to 9.3 mo.CEA and CA19-9 were analyzed in 28 pts. CEA and CA19-9 decreased in 96% and 82% of these pts, respectively. Among 15 pts with treatment duration ≥5.6 mo, median/mean % decreases were 97%/79% for CEA and 92%/82% for CA19-9 in confirmed responders (n=6). Respective decreases in pts with prolonged SD (n=9) were similar: 84%/68% for CEA and 89%/68% for CA19-9. Updated safety, efficacy, and tumor marker results will be provided. Conclusions: ENCO + BINI + CETUX is generally well tolerated and has encouraging clinical activity in BRAFV 600E mCRC, with a confirmed ORR of 41%. In pts with study treatment duration ≥5.6 mo, the tumor markers CEA and CA19-9 decreased markedly and to the same degree in responders vs pts with prolonged SD, providing additional evidence of the meaningful clinical activity of this regimen. Clinical trial information: NCT02928224.

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Emiris, I. Z., and A. Galligo. "Book Review: Polynomial and Matrix Computations Volume 1: Fundamental Algorithms by D. Bini and V. Pan." ACM SIGSAM Bulletin 30, no. 3 (1996): 21–23. http://dx.doi.org/10.1145/240065.570109.

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Buchmann, K., and J. Bresciani. "Ultrastructural evalution of mebendazole action in Pseudodactylogyrus bini (Monogenea), gill parasites from Luopean eel Anguilla Anguilla." Diseases of Aquatic Organisms 19 (1994): 55–60. http://dx.doi.org/10.3354/dao019055.

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Wu, Shu-Lin, and Tao Zhou. "Diagonalization-based parallel-in-time algorithms for parabolic PDE-constrained optimization problems." ESAIM: Control, Optimisation and Calculus of Variations 26 (2020): 88. http://dx.doi.org/10.1051/cocv/2020012.

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Solving parabolic PDE-constrained optimization problems requires to take into account the discrete time points all-at-once, which means that the computation procedure is often time-consuming. It is thus desirable to design robust and analyzable parallel-in-time (PinT) algorithms to handle this kind of coupled PDE systems with opposite evolution directions. To this end, for two representative model problems which are, respectively, the time-periodic PDEs and the initial-value PDEs, we propose a diagonalization-based approach that can reduce dramatically the computational time. The main idea lies in carefully handling the associated time discretization matrices that are denoted by Bper and Bini for the two problems. For the first problem, we diagonalize Bper directly and this results in a direct PinT algorithm (i.e., non-iterative). For the second problem, the main idea is to design a suitable approximation B̂per of Bini, which naturally results in a preconditioner of the discrete KKT system. This preconditioner can be used in a PinT pattern, and for both the Backward-Euler method and the trapezoidal rule the clustering of the eigenvalues and singular values of the preconditioned matrix is justified. Compared to existing preconditioners that are designed by approximating the Schur complement of the discrete KKT system, we show that the new preconditioner leads to much faster convergence for certain Krylov subspace solvers, e.g., the GMRES and BiCGStab methods. Numerical results are presented to illustrate the advantages of the proposed PinT algorithm.

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Journal articles on the topic 'Bini'

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