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Relevant bibliographies by topics / Bio-behavior / Dissertations / Theses

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Dissertations / Theses on the topic 'Bio-behavior'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Karimi, Shima. "Corrosion behavior of metallic bio-implant alloys." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46510.

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The most common metallic biomaterials are 316L, Co-28Cr-6Mo, and Ti-6Al-4V alloys used as prostheses and fixation devices. These materials are biocompatible and have high corrosion resistance. However, metallic biomaterials are not completely inert in the body. The presence of dissolved oxygen, chloride, phosphate, and organic molecules in the body fluids could influence their corrosion behavior. Protein is one of the components of the human body fluids. Body fluids contain different concentrations of protein and even the protein concentration varies at the implant/tissue interface during th

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2

Xu, Peng. "Bio-inspired VLSI systems from synapse to behavior/." College Park, Md. : University of Maryland, 2008. http://hdl.handle.net/1903/8367.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Electrical and Computer Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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3

Rozite, Liva. "Non-linear behavior of bio-based composite : characterization and modeling." Licentiate thesis, Luleå tekniska universitet, Materialvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-18691.

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The development and application of bio-based composite materials have been frequently studied. Most of the work is done on quasi-static performance of these materials. However, these composites are highly non-linear therefore there is need for investigation of their viscelastic and viscoplastic behavior. This thesis is dealing with characterization and modeling of behavior of bio-based composite. The effect of temperature and relative humidity on mechanical behavior of natural fiber reinforced bio-based matrix composites subjected to tensile loading was investigated. Composites with different

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4

Hosseini, Moghadam Seyed Mazdak, and Mohamed Alshihabi. "Mechanical behavior of a bio-based composite : influences of production conditions." Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-57314.

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Some mechanical properties of DuraPulp, a bio-based, bio-degradable composite made from polylactic acid (PLA) and pulp fibers, were determined. Focus was put on the conditions during productions whereby three different press times were studied. Additionally, two different material compositions (PLA to fiber ratios) were used. Uniaxial tensile tests with two different load rates, one and 50 mm/min, were performed. An increase in maximum strength and E-modulus of DuraPulp was observed by increasing the press time, while PLA content decreased the maximum strength and E modulus.

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Aryaei, Ashkan. "Mechanical Properties of Bio-nanocomposites and Cellular Behavior under Mechanical Stimulation." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1398361357.

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6

Li, Si Wan. "A study of micro-rheological behavior of bio-degradable PHA blends /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?CENG%202003%20LI.

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7

Mai, Ngoc Anh, and Klaus Janschek. "Bio-inspired Optical Flow Interpretation with Fuzzy Logic for Behavior-Based Robot Control." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-26252.

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This paper presents a bio-inspired approach for optical flow data interpretation based on fuzzy inference decision making for visual mobile robot navigation. The interpretation results of regionally averaged optical flow patterns with pyramid segmentation of the optical flow field deliver fuzzy topological and topographic information of the surrounding environment (topological structure from motion). It allows a topological localization in a global map as well as controlled locomotion (obstacle avoidance, goal seeking) in a changing and dynamic environment. The topological optical flow process

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Srinivasan, Jagannathan. "Sensing animal group behavior and bio-clutter in the ocean over continental shelf scales." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67587.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 267-294).<br>Fish populations often comprise the largest biomass in a productive marine ecosystem. They typically play an essential role in inter-trophic energy transport, and serve as a mainstay for human consumption comprising roughly 16% of the animal protein consumed by the world's population. Despite their ecological importance, there is substantial evidence that fish populations are declining worldwide, motivati

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Wenner, Benjamin A. "Effect of Bio-Mos® and outdoor access housing on pig growth, feed efficiency, health, behavior and carcass ultrasound traits." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1345574215.

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10

CUCCA, FLAVIA. "Dopamine responsiveness in Nucleus Accumbens Shell and Core and Prefrontal Cortex during operant behavior for sucrose." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266445.

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Dopamine is implicated in the responsiveness to rewarding properties of natural and pharmacological stimuli. Conditioned stimuli (CS), linked to rewards such as food or drugs of abuse (uncontidioned stimuli, US), are essential to support the motivated behaviour. The role of mesocortical and mesolimbic DA in response to food CS after instrumental paradigm still remains unclear. The aim of our study was to investigate by microdialysis the impact of instrumental food CSs and US on behaviour and on basal DA in three terminal DA areas: shell and core of nucleus accumbens (NAc) and medial prefronta

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11

Farhadi-Khouzani, Masoud [Verfasser]. "Study of Structures and Crystallization Behavior of Amorphous Calcium Carbonate (ACC) and its Application in Bio-inspired Materials / Masoud Farhadi-Khouzani." Konstanz : Bibliothek der Universität Konstanz, 2017. http://d-nb.info/1132995663/34.

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12

Gaburro, Stefano. "Autonomic function in mice with altered anxiety/depression related behavior." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426126.

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Autonomic dysregulation has been described in patients suffering from anxiety and depression disorders. The vast majority of animal studies investigating autonomic function in anxiety and depression involve “non pathological” models. Thus, the aim of the present study was to investigate parameters of autonomic regulation (e.g. body temperature, heart rate and heart rate variability) in a mouse model selectively bred for high innate anxiety (HAB) versus normal anxiety like behaving mice (NAB). Basal (home cage) and mild unconditioned stressor conditions (e.g. novel cage, open field) did not r

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MORBIATO, ELISA. "Modulation of circadian rhythms by glucocorticoids." Doctoral thesis, Università degli studi di Ferrara, 2020. http://hdl.handle.net/11392/2478787.

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Il comportamento è concepito come una relazione dipendente stimolo-risposta tra un input sensoriale e una risposta motoria. Nel passaggio da input a output, l’omeostasi interna è continuamente modellata per mantenere un equilibrio ottimale della spesa energetica. Lo scopo ultimo di mantenere l’omeostasi in relazione al mondo circostante viene raggiunto attraverso la produzione di comportamenti adattativi che permettono di incrementare la fitness alla luce della selezione naturale. L’ambiente circostante può essere sia prevedibile sia imprevedibile. La prima condizione ha portato all’evoluzion

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Cisneros, Luis. "The Organized Melee: Emergence of Collective Behavior in Concentrated Suspensions of Swimming Bacteria and Associated Phenomena." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195513.

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Suspensions of the aerobic bacteria {\it Bacilus subtilis} develop patterns and flows from the interplay of motility, chemotaxis and buoyancy.In sessile drops, such bioconvectively driven flows carry plumes down the slanted meniscus and concentrate cells at the drop edge, while in pendant drops such self-concentration occurs at the bottom.These dynamics are explained quantitatively by a mathematical model consisting of oxygen diffusion and consumption, chemotaxis, and viscous fluid dynamics.Concentrated regions in both geometries comprise nearly close-packed populations, forming the collective

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15

Karimian, Kimia. "BioCompT - A Tutorial on Bio-Molecular Computing." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367943120.

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16

Richetto, J. "LATE PRENATAL INFECTION AND NEURODEVELOPMENTAL DISORDERS: CHARACTERIZATION OF AN IMMUNE-MEDIATED MOUSE MODEL." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/244209.

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Compelling evidence suggests that the aetiology of multifactorial and multisymptomatic psychiatric diseases include exposures to adverse events during prenatal and early postnatal life, which may disrupt the correct maturation of neural system and lead to long-lasting changes in brain function. Prenatal insults, and in particular prenatal infection, could thus act as a “primer” for the neuropsychiatric route, even if the specificity of the illness that develops is strongly influenced by the genetic and environmental context in which the process occurs (Meyer, 2013b). A similar concept of “earl

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Ogabi, Raphael. "Experimental study of the fire behavior of synthetic and bio-sourced composite materials impacted by heat flux density on a medium and large scale." Electronic Thesis or Diss., Bourges, INSA Centre Val de Loire, 2024. http://www.theses.fr/2024ISAB0001.

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Dans le but d'améliorer la compréhension du comportement au feu des matériaux composites synthétiques et biosourcés, l'objectif de cette thèse vise à mettre en évidence des phénomènes physico-chimiques en rapport avec la sécurité incendie pour des matériaux pouvant être utilisés dans des applications aéronautiques et/ou automobiles. Dans ce contexte, une partie des tests expérimentaux a été réalisée à l'aide du brûleur NexGen développé suivant les exigences de la FAA afin de réaliser des tests de certification au feu. La deuxième partie des résultats a été obtenue à l’aide d’un cône calorimètr

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Mohan, Adithya Venkatesh. "Training an Artificial Bat: Modeling Sonar-based Obstacle Avoidance using Deep-reinforcement Learning." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613685804686552.

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Patil, Indrajeet. "A multimodal investigation of moral decision making in harmful contexts." Doctoral thesis, SISSA, 2016. http://hdl.handle.net/20.500.11767/4910.

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Since the two landmark publications in moral psychology (Greene, Sommerville, Nystrom, Darley, & Cohen, 2001; Haidt, 2001), the field has experienced an affective revolution that has put emotions at the center of the stage. Although work on exploring role of emotions in assessing morality of various types of moral acts (impure, unfair, etc.; Haidt, 2007) abounds, studying its role in harmful behaviors presents a unique challenge. The aversion to harming others is an integral part of the foundations of human moral sense and it presents itself in the form of deeply ingrained moral intuitions (Ha

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Robles, Astrid. "Bio-coal pre-treatmeant for maximized addition in briquettes and coke." Thesis, Luleå tekniska universitet, Industriell miljö- och processteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-66465.

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Carbon dioxide emissions to the atmosphere today cause problems around the world. In Sweden, the steel production contributes significantly to carbon dioxide emissions. The steel industry challenge is to improve the metallurgical processes to decrease the carbon dioxide emissions. One way to reduce the emissions is to use renewable carbon sources. The blast furnace process is a counter current reduction process for ironmaking. Raw materials such as iron ore agglomerates, coke and slag formers are charged at the top of the furnace while oxygen-rich blast air and powdered coal are injected in th

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21

PASINI, SILVIA. "Role of activated transcription factor 4 (ATF4) in learning and memory." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/27132.

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The aim of this study is to understand the role of Activated Transcription Factor 4 (ATF4) in the processes of learning and memory. The topic of learning and memory has always aroused great interest from time immemorial and although a lot of researches have been focused on this subject for a long time, many mechanisms have not yet been fully understood. Identifying the players and the mechanisms involved in learning and memory is of utmost importance because deficits in these cognitive functions are symptoms of common neurological diseases like stoke, depression, dementia and Alzheimer’s dis

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Cattaneo, A. M. "UNVEILING SENSORY MECHANISMS FOR THE CONTROL OF TWO INSECT PESTS: FROM BEHAVIOR TO MOLECULAR INTERACTIONS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/347230.

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Pest control strategies targeting insect olfaction represent a promising venue for control of tortricid insects (Lepidoptera: Tortricidae). Among tortricids, the grapevine moth Lobesia botrana (Denis and Schiffermüller) and the codling moth Cydia pomonella (L.) are serious pests for worldwide production of fruit crops. We employed several approaches to the olfactory system, from electrophysiological and behavioral studies in the grapevine moth, to bioinformatic and molecular studies of olfactory sensory proteins in the codling moth. At the receptor level, we studied both the Olfactory Receptor

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DE, ROSE FRANCESCAELENA. "Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266643.

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Drosophila melanogaster (Dm) is a valuable genetic model for exploring molecular, genetic and cellular aspects of neurodegeneration in Parkinson's disease (PD), for further understanding its etiology and pathogenesis and making valid contributions to drug screening. This study used two loss-of-function Dm mutants, PINK1B9 and LRRK2WD40 (deletion of WD40 domain), that both express essential phenotypic characteristics of PD in humans, albeit with a different biochemical mechanism and pathways. Since therapeutic treatments to limit the onset of PD are not yet available and the common approach to

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COZZI, LORENA. "AN EXPLORATIVE ASSESSMENT OF POTENTIAL NOVEL DIAGNOSTIC AND PROGNOSTIC BIOMARKERS FOR IDENTIFICATION OF PRODROMAL PARKINSON¿S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/482005.

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ABSTRACT Background - Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer, primarily affecting about 6 million people worldwide. An early identification of PD is one of the main challenges in neurological research because to date, its diagnosis is still largely based on the clinical assessment of cardinal motor signs (bradykinesia, rigidity, resting tremor and postural instability) resulting by a progressive degeneration of dopaminergic neurons of the substantia nigra and locus coeruleus. However, impaired motor function appears when over 60% of t

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RAMUNDO, GRETA. "Effetti dell’ambiente materno precoce e dell’espressione di NPY-1r in area limbica su comportamento e riproduzione di topi femmine KO condizionali." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2022. https://hdl.handle.net/11380/1293287.

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Il fenotipo di un organismo, cioè l’insieme delle sue caratteristiche morfologiche e funzionali, è determinato dall’espressione del suo patrimonio genetico e dalle influenze dell’ambiente circostante. Nei mammiferi l’ambiente materno precoce riveste un ruolo fondamentale nel regolare lo sviluppo postnatale e il fenotipo. Studi condotti su roditori hanno dimostrato come la qualità delle cure materne influenzi comportamento, risposta allo stress e metabolismo della progenie in età adulta. Nel modello murino caratterizzato dalla delezione condizionale (ristretta ai neuroni eccitatori del prosence

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CAVIOLA, GIADA. "Impatto dell’ambiente materno precoce e del sesso sul comportamento e metabolismo in due modelli murini KO." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1200998.

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Le interazioni gene-ambiente svolgono un ruolo critico nella modulazione dello sviluppo dell’organismo: in particolare l’ambiente materno precoce sembra essere un fattore chiave dello sviluppo neuro-comportamentale. Il legame tra la madre e il figlio infatti è considerato la relazione sociale più comune e duratura nei mammiferi, filogeneticamente conservato tra le diverse specie. Evidenze sperimentali indicano che l’ambiente materno precoce può modulare la regolazione dell’espressione genica; diversi studi hanno dimostrato che animali che avevano ricevuto maggiori cure materne durante il primo

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NIGRO, MARCO. "Cortical and subcortical neuronal substrates of social behavior." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/939848.

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Social behavior is one of the most important properties of animal life and it plays a critical role in biological adaptations. However, the neural substrates of social cognitive processing are complex and largely unknown. The “social brain” network, involving a range of cortical and subcortical regions and connective pathways, varies depending on task demands. The aim of this thesis was to clarify the implication of different brain pathways and systems in different aspects of mice social behavior. The work presented in the first two chapters of the thesis was to develop and validated a new beh

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MANCHIA, MIRKO. "Valutazione del rischio genetico di comportamento suicidario nel disturbo bipolare: analisi di 737 pedigrees." Doctoral thesis, Università degli Studi di Cagliari, 2012. http://hdl.handle.net/11584/266088.

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Suicide is a significant cause of mortality in patients with major affective disorders(MAD). Suicidal acts are typically more lethal in MAD. A large contribution to the suicide risk derives from the presence of family history of suicidal behavior. Other clinical factors, such as treatment with lithium can reduce the suicide risk in patients with MAD. In this work the results of the distribution of suicidal behavior in a large sample of families with bipolar-spectrum disorder, and its relation to family history of MAD and bipolar disorder (BD) are presented. Methods: The lifetime prevalence o

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Bellanger, Manuel. "Modélisation de mécanismes institutionnels et impacts bio-économiques de systèmes de gestion de quotas : application à la pêcherie de sole du golfe de Gascogne." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0037/document.

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En France, où les droits de pêches ne sont pas transférables, la gestion des quotas de pêche est essentiellement déléguée aux organisations de producteurs (OP), lesquelles se voient attribuer des allocations collectives et sont responsables de la gestion des possibilités de pêche de leurs adhérents. On peut ainsi s’interroger sur la manière dont la présence des OP au sein des institutions peut permettre d’améliorer les performances écologiques,économiques et sociales de la gestion des pêches en comparaison avec d’autres formes institutionnelles telles que les systèmes de quotas individuels tra

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Cattaneo, Alberto Maria. "Unveiling sensory mechanisms for the control of two insect pests: from behaviour to molecular interactions." Doctoral thesis, country:IT, 2015. http://hdl.handle.net/10449/29924.

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Pest control strategies targeting insect olfaction represent a promising venue for control of tortricid insects (Lepidoptera: Tortricidae). Among tortricids, the grapevine moth Lobesia botrana (Denis and Schiffermüller) and the codling moth Cydia pomonella (L.) are serious pests for worldwide production of fruit crops. We employed several approaches to the olfactory system, from electrophysiological and behavioral studies in the grapevine moth, to bioinformatic and molecular studies of olfactory sensory proteins in the codling moth. At the receptor level, we studied both the Olfactory Receptor

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PAGET, BLANC VINCENT. "Investigating the molecular basis of the shift from goal-directed to habitual behavior." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/931913.

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According to current theories, actions are controlled by the balance between two dissociable processes acquired during learning. The flexible, goal-directed control of behavior, which is dependent on the causal relationship between the action and its outcome (A-O) and the automatic and inflexible habitual behavior that is insensitive to changes in A-O contingencies. The amount of training critically defines which cognitive process determines action control. Whilst at early stages behavior is goal-directed; with repeated practice behavior gradually becomes automatic and habitual. Lesion studies

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Mazzoni, Alberto. "From neuronal networks to behavior: dynamics of spontaneous activity and onset of movement in the leech." Doctoral thesis, SISSA, 2007. http://hdl.handle.net/20.500.11767/4000.

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Animal behavior was once seen as a chain of reactions to stimuli from the environment. From chemotaxis in bacteria to mammals withdrawing from painful stimuli, most of the actions taken by animals are clearly driven by external inputs. Reflexes were among the first phenomena to be studied to have an insight on the dynamics of the nervous system. Later, a step forward was the discovery of central pattern generators: once a behavior is started by a stimulus, some neuronal networks are able to maintain it without further inputs from the environment. The nervous system of all animals, howeve

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SAPORITI, SIMONA. "IN SILICO INVESTIGATIONS OF N-GLYCOSYLATION ROLE IN MODULATING IGG1 CONFORMATIONAL BEHAVIOR AND FC EFFECTOR FUNCTIONS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/796070.

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Nowadays, monoclonal antibodies (mAbs) occupy a relevant position in the pharmaceutical market, since they are often the preferred choice in the treatment of several diseases. Both for mAbs and other biopharmaceutical products, a decisive step in their development is represented by the critical quality attribute (CQA) assessment. Recently, with the advent of novel computational resources and high-performance computers, many in silico approaches have been implemented by companies to speed up the identification of potential CQAs and to drive the product characterization. Within this context, amo

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Howe, Margaret Lillian. "The bio-sociological relationship between Western Australian Aboriginals and their dogs." Thesis, Howe, Margaret Lillian (1993) The bio-sociological relationship between Western Australian Aboriginals and their dogs. PhD thesis, Murdoch University, 1993. https://researchrepository.murdoch.edu.au/id/eprint/78/.

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The hypothesis central to this study is that distinctly Aboriginal patterns of relationship between humans and dogs are still evident in contemporary Aboriginal groups. The relationship's sociological characteristics in traditional and contemporary settings and its implications for canine and human health are also investigated. Field research employing survey, quantitative observation and specimen analysis techniques was conducted in 9 Western Australian Aboriginal groups of various backgrounds and settings. Results were compared to historic-traditional accounts and dog ownership studies in

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Howe, Margaret Lillian. "The bio-sociological relationship between Western Australian Aboriginals and their dogs /." Access via Murdoch University Digital Theses Project, 1993. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060815.151043.

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MELIS, MELANIA. "Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266417.

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In this thesis, we studied two examples of the sensitivity to chemical stimuli and its role in the food preferences in two models of the evolutionary scale. The red swamp crayfish Procambarus clarkii (Girard, 1852) (Crustacea: Decapoda) is an invasive species of freshwater habitats that has spread worldwide. In crayfish, like in other decapod crustaceans, reception of chemical cues occurs by way of peripheral chemoreceptors grouped within sensory hairs and typically located on the cuticle of cephalothoracic appendages. Antennules and pereopods (walking legs), in particular, have been reported

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FIGORILLI, MICHELA. "Polysomnographic markers of REM sleep behavior disorder in Parkinson’s Disease: methodological issues, diagnostic accuracy and progression over time." Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/260589.

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Up to 60% of Parkinson’s disease (PD) patients have REM sleep behavior disorder (RBD), a parasomnia characterized by a loss of REM sleep muscle atonia and dream-enacting behaviors, usually associated to vivid dreams. REM sleep without atonia (RSWA), characterized by a sustained tonic and/or phasic muscle activity during REM sleep, is the polysomnographic hallmark of RBD. PD patients with RBD (PDRBD+) are more severely impaired in both motor and non-motor domains, compared to those without RBD, and they have an increased risk of dementia. Thus, RBD may be a biomarker of more widespread/malignan

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PANDOLFI, LAURA. "Investigating the effects of drug-loaded nanoparticles on the cellular behavior of proliferative diseases." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/101974.

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A common feature of nanoparticles (NPs) is their large surface area to volume ratio that makes them an attractive tools for the development of drug delivery systems, improving several properties of ‘‘free’’ drugs: solubility, pharmacokinetic profile and biodistribution. During my PhD, I studied different nanovehicles loaded with “free” hydrophobic drugs against three “over-proliferative” diseases to evaluate the efficacy and safety of nanodrugs. In the first year, I focused the anti-proliferative effect of ASC-J9, a promise in the treatment of prostate cancer. ASC-J9 is a very hydrophobic

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PODDA, MARTA. "Indagine conoscitiva sul comportamento sesuale dai 2 ai 12 anni attraverso il child sexul behavior inventory: considerazioni neuropsicoendocrinologiche." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/746.

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Scopo: Scopo del presente lavoro è stato quello di indagare la sessualità infantile nella popolazione italiana fra i 2 ed i 12 anni attraverso l’osservazione materna e valutare le differenze di genere nell’espressione di tali comportamenti. Parallelamente si sono volute creare le condizioni per la validazione del Child Sexual Behavior Inventory 3 (Friedrich, 1997) in lingua italiana. Materiali e Metodi: Dopo aver tradotto il Child Sexual Behavior Inventory mediante translation back translation, si è svolta una ricerca pilota per valutare l’applicabilità dello strumento nella popolazione ita

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Castellan, Martina. "YAP/TAZ in the regulation of epidermal stem cell fate and glioblastoma cell behavior." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427144.

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Cells within a tissue respond to mechanical forces and changes in the physical properties of the external microenvironment; the two transcriptional regulators YAP and TAZ transduce these physical inputs into biological responses. In this scenario the epidermis is a point in case as it represents a real mechanosensitive tissue for its structure and functions. In the first part of this thesis, we showed that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) controls the balance between proliferation and differentiation in epidermal SCs. Furthermore, we established a

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CESARINI, VALERIANA. "Regulation of neuroectodermal cancers invasive behavior: role of PDE5 in Glioblastoma Multiforme and of Sox2 in Melanoma." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/203040.

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Neuroectoderm is one of the earliest cell lineages that establish at gastrulation. Neuroectodermal tumors arise from cells originating from the primitive neuroectoderm, which include glial cells, neurons, neural crest cells, parenchymal cells of the pineal gland and primitive embryonic cells of brain and retina. Both melanocytes and glial cells are derived embryologically from the neuroectoderm. Their malignant transformed counterparts, melanoma and glioma cells, respectively, may share common antigens. Numerous tumor-associated antigens have been identified in melanomas but only a few in glio

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Liaudanskaya, Volha. "Bottom-up Tissue Engineering: The Effect of 3D Tissue Fabrication Strategies on Cellular Behavior." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/367766.

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Organ failure is one the biggest problems, doctors face every day. Many patients are not able to get a transplant, but even those who recieved it, may undergo painful process of organ rejection and be on the transplant waiting list again. Organ transplants shortage is severe problem in current medicine that has many ethical and medical issues. To solve this problem, the new direction in regenerative medicine was formed, organ prinitng. The main goal of organ printing is fabrication of organ replacements that would mimic the original ones in terms of complexity and functionality. By direct fabr

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MELONI, MARIO. "A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of the 5-Hydroxytryptophan on REM Sleep Behavior Disorder, Levodopa-Induced Motor Complications and Neuropsychiatric Disorders in Idiopathic Parkinson's disease." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255971.

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Background and purpose: Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by the motor symptoms of bradykinesia, tremor, rigidity and postural instability. However, non-motor symptoms such as depression, apathy and rapid eye movement sleep behavior disorder (RBD) are also frequent and play a significant role. Several studies have indicated that altered serotonergic neurotransmission may contribute to the motor and non-motor features commonly associated with PD such as levodopa-induced motor complications, sleep disorders, apathy and depression.The 5-Hydroxytrypt

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Liaudanskaya, Volha. "Bottom-up Tissue Engineering: The Effect of 3D Tissue Fabrication Strategies on Cellular Behavior." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1471/1/10.03.15_Doctoral_thesis_modified.pdf.

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Organ failure is one the biggest problems, doctors face every day. Many patients are not able to get a transplant, but even those who recieved it, may undergo painful process of organ rejection and be on the transplant waiting list again. Organ transplants shortage is severe problem in current medicine that has many ethical and medical issues. To solve this problem, the new direction in regenerative medicine was formed, organ prinitng. The main goal of organ printing is fabrication of organ replacements that would mimic the original ones in terms of complexity and functionality. By direct fabr

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Chollet, Benjamin. "Étude du comportement au feu de matériaux polymères contenant des bio-nanoparticules fonctionnalisées." Thesis, IMT Mines Alès, 2018. http://www.theses.fr/2018EMAL0004/document.

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La volonté croissante de diminuer l’empreinte écologique des matières plastiques favorise le développement de polymères et d’additifs issus de ressources renouvelables afin de limiter leur impact environnemental. Les retardateurs de flamme sont une famille d’additifs qui jouent un rôle crucial dans de nombreux domaines d’application où le risque d’incendie est avéré. Cette étude vise donc à développer de nouveaux systèmes retardateurs de flamme à partir de composés issus de la biomasse afin d’améliorer le comportement au feu d’un polymère bio-sourcé, l’acide polylactique (PLA). La lignine et l

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VOLTA, Mattia. "Leucine-rich repeat kinase 2, synaptic morphology and motor behavior." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389441.

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Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are known to cause late-onset, familial forms of Parkinson’s Disease, with prevalence up to 40% in specific populations. These mutations are also linked to sporadic PD, highlighting the importance of the related protein in the development of the disease. LRRK2 is a large, complex, multi-domain protein, with two main enzymatic activities: a GTPase domain (bearing three pathogenic mutations) and a kinase domain, in which the most common mutation (G2019S) is found. Even though the precise cellular functions of LRRK2 are not known, LRRK2

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Figura, Andrea. "Psychological and psychosomatic aspects of bariatric surgery for the treatment of obesity in adults." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19115.

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Das Krankheitsbild der Adipositas hat sich weltweit zu einem relevanten Gesundheitsproblem entwickelt. Die bariatrische Chirurgie wird zunehmend als wirkungsvolle Behandlung bei schwer ausgeprägter Adipositas eingesetzt. Jedoch ist über die Rolle psychologischer Variablen im bariatrischen Behandlungsverlauf noch wenig bekannt. Die vorliegende Dissertation untersucht Einfluss und Veränderung patientenberichteter Gesundheitsmerkmale in der chirurgischen Adipositastherapie. Dazu werden in einer naturalistischen Beobachtungsstudie Patienten mit schwerer Adipositas vor und im Durchschnitt zwei Jahr

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BARBIERI, VALENTINA. "Computational modeling of the enzymatic activities of biomolecules at different scales: from quantum mechanical reaction studies to systemic understanding of cell behavior." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29145.

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The aim of the thesis is the development of computational models of the enzymatic activity of biomolecules at different scales. Parallel investigations have been carried out at a quantum level to study the reactivity of an enzyme from an electronic point of view, and at a systemic level using simulation techniques to determine the role of enzymes in the network of cellular reactions. Starting from the lowest complexity level, the thesis begins with two computational studies with the aims of describing the molecular mechanism of the catalytic reaction between amavadin and methyl mercaptoacet

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Chen, Keke. "Roll-to-Roll Manufacturing and Real-Time Characterization of Bio-Functional Polymers." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1548177736839976.

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Bartiromo, Fiorina <1977&gt. "Development of functional MRI protocols in the study of neurodegenerative diseases: MRI study in patients with REM sleep behavior disorder, idiopathic Parkinson's disease and multisystem atrophy." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10475/1/vers%20finale%2030_09_22%20FB%20File%20unico%20frontespizio.pdf.

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In the central nervous system, iron in several proteins is involved in many important processes: oxygen transportation, oxidative phosphorylation, mitochondrial respiration, myelin production, the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation, modification of lipids, proteins, carbohydrates, and DNA, lead to neurotoxicity. Moreover increased levels of iron are harmful and iron accumulations are typical hallmarks of brain ageing and several neurodegenerative disorders part

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