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Journal articles on the topic 'Bioactive gla'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Zhu, Weidong, Yi Zhang, Yueshan Li та Hao Wu. "Glaucocalyxin A Attenuates IL-1β-Induced Inflammatory Response and Cartilage Degradation in Osteoarthritis Chondrocytes via Inhibiting the Activation of NF-κB Signaling Pathway". Disease Markers 2022 (26 лютого 2022): 1–9. http://dx.doi.org/10.1155/2022/6516246.

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Glaucocalyxin A (GLA) is a bioactive natural compound with anti-inflammatory activity. Herein, the role of GLA in osteoarthritis (OA) was evaluated. Our results demonstrated that the IL-1β-induced inducible nitric oxide synthase (iNOS) and cyclooygenase-2 (COX-2) expression, two enzymes resulting in the release of nitric oxide (NO) and PGE2, were also prevented by GLA in chondrocytes. Moreover, GLA suppressed inflammatory cytokines production in chondrocytes. In addition, the elevated expressions of MMPs and ADAMTSs and the degradation of aggrecan and collagen II were reversed by GLA in chondr

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González-Fernández, María José, Ignacio Ortea та José Luis Guil-Guerrero. "α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells". Toxicology Research 9, № 4 (2020): 474–83. http://dx.doi.org/10.1093/toxres/tfaa046.

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Abstract α-Linolenic acid (ALA, 18:3n-3) and γ-gamma linolenic acid (GLA, 18:3n-6) are polyunsaturated fatty acids (PUFA) that improve the human health. The present study focused on testing the in vitro antitumor actions of pure ALA and GLA on the HT-29 human colorectal cancer cell line. Cell viability was checked by MTT ((3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test, cell membrane damage by the lactate dehydrogenase assay, apoptosis was tested by both caspase-3 activity trial and transmission electron microscopy images, and protein composition was analyzed by quantitativ

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Das, Undurti N. "“Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications." Biomolecules 11, no. 2 (2021): 241. http://dx.doi.org/10.3390/biom11020241.

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Lipids are an essential constituent of the cell membrane of which polyunsaturated fatty acids (PUFAs) are the most important component. Activation of phospholipase A2 (PLA2) induces the release of PUFAs from the cell membrane that form precursors to both pro- and ant-inflammatory bioactive lipids that participate in several cellular processes. PUFAs GLA (gamma-linolenic acid), DGLA (dihomo-GLA), AA (arachidonic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are derived from dietary linoleic acid (LA) and alpha-linolenic acid (ALA) by the action of desaturases whose activity

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Kousparou, Christina, Maria Fyrilla, Anastasis Stephanou, and Ioannis Patrikios. "DHA/EPA (Omega-3) and LA/GLA (Omega-6) as Bioactive Molecules in Neurodegenerative Diseases." International Journal of Molecular Sciences 24, no. 13 (2023): 10717. http://dx.doi.org/10.3390/ijms241310717.

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Neurodegenerative diseases are characterized by neuroinflammation, neuronal depletion and oxidative stress. They coincide with subtle chronic or flaring inflammation, sometimes escalating with infiltrations of the immune system cells in the inflamed parts causing mild to severe or even lethal damage. Thus, neurodegenerative diseases show all features of autoimmune diseases. Prevalence of neurodegenerative diseases has dramatically increased in recent decades and unfortunately, the therapeutic efficacy and safety profile of available drugs is moderate. The beneficial effects of eicosapentaenoic

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Jayaraju, Kummu Jyothsna, and Beludari Mohammed Ishaq. "Analytical characterization of biomarkers in an optimized novel antidiabetic polyherbal formulation using high-performance thin-layer chromatography and liquid chromatography with tandem mass spectrometry." Egyptian Pharmaceutical Journal 20, no. 4 (2021): 329–38. http://dx.doi.org/10.4103/epj.epj_35_21.

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Background Diabetes mellitus is a chronic health issue that requires novel approaches to treatment and a multimodal approach to prevention. In the treatment of diabetes, a polyherbal formulation is the finest alternative medicine. A polyherbal formulation was developed in-house and evaluated for its antidiabetic potential on streptozotocin-induced diabetes rat. The same extract was now characterized analytically utilizing a variety of methods. Objective The goal of this study was to quantify the biomarkers in a novel antidiabetic polyherbal formulation made in-house with Cinnamonum zeylanicium

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Berzal, Gonzalo, Martín García-González, Natalia Castejón, Paz García-García, Gloria Fernández-Lorente, and Francisco J. Señoráns. "Biocatalysts Based on Immobilized Lipases for the Production of Ethyl Esters of Fatty Acids including Bioactive Gamma-Linolenic Acid from Borage Oil." Catalysts 13, no. 9 (2023): 1275. http://dx.doi.org/10.3390/catal13091275.

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In the present work, borage oil (Borago officinalis) was used as the main source of gamma linolenic acid (GLA) to obtain ethyl esters by enzymatic ethanolysis using immobilized enzymes for its application in the food industry. Commercial Thermomyces lanuginosus lipase (TLL) was compared to chemical ethanolysis in alkaline medium. In addition, TLL was immobilized by adsorption on hydrophobic porous support (Octadecyl-Sepabeads®) to compare the results. Fatty acid ethyl ester (FAEE) yields of both reactions were compared under the same conditions (25 °C and 200 rpm) and analyzed by GC-MS. Moreov

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Ciganović, Petar, Katarzyna Jakimiuk, Michał Tomczyk, and Marijana Zovko Končić. "Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity." Antioxidants 8, no. 10 (2019): 445. http://dx.doi.org/10.3390/antiox8100445.

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A green ultrasound-assisted extraction (UAE) method using glycerol/water mixtures for extraction of licorice (Glycyrrhiza glabra) bioactive constituents was developed in this study. The response surface method, according to the Box-Behnken design, was employed to optimize the extraction parameters: glycerol concentration (X1), temperature (X2), and the amount of herbal drug used in the production (X3). The responses were content of total phenols (TP), TP extraction efficiency (TPy) and the content of licorice characteristic constituents, glabridin (Gla) and isoliquiritigenin (Iso). Response su

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Kalampounias, Georgios, Chrysavgi Gardeli, Spyridon Alexis, et al. "Poly-Unsaturated Fatty Acids (PUFAs) from Cunninghamella elegans Grown on Glycerol Induce Cell Death and Increase Intracellular Reactive Oxygen Species." Journal of Fungi 10, no. 2 (2024): 130. http://dx.doi.org/10.3390/jof10020130.

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Cunninghamella elegans NRRL-1393 is an oleaginous fungus able to synthesize and accumulate unsaturated fatty acids, amongst which the bioactive gamma-linolenic acid (GLA) has potential anti-cancer activities. C. elegans was cultured in shake-flask nitrogen-limited media with either glycerol or glucose (both at ≈60 g/L) employed as the sole substrate. The assimilation rate of both substrates was similar, as the total biomass production reached 13.0–13.5 g/L, c. 350 h after inoculation (for both instances, c. 27–29 g/L of substrate were consumed). Lipid production was slightly higher on glycerol

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Neha Kumari and Neelesh Kumar Maurya. "Cyanobacteria's beneficial impacts on human wellness." International Journal of Agricultural Invention 8, no. 2 (2023): 201–5. https://doi.org/10.46492/ijai/2023.8.2.9.

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Because of their colour, cyanobacteria are also known as blue-green algae (BGA). These are gram-positive prokaryotes. They manufacture their own food by photosynthesis and are rich in colours such as chlorophyll a, carotenoids, and phycobilins. Blue-green algae have been demonstrated to be useful in the treatment of hypertension and may be used as a protein supplement. Moreover, it is used to treat high levels of cholesterol or other fats (lipids) in the blood, diabetes, obesity, and a variety of other diseases. BGA are healthy natural products that are high in essential amino acids, gamma-lin

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Arshad, Ahmad Najar, Ashaq Mohd, Ahmad Bhat Nisar, et al. "A Diagnostic approach for same looking plants for their Pharmacognosy value." Indian Journal of Science and Technology 14, no. 14 (2021): 1105–15. https://doi.org/10.17485/IJST/v14i14.2346.

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Abstract <strong>Objective:</strong> To establish diagnostic features of same looking plants (C. gigantea and C. procera) and also to explore the diurnal influence on their Pharmacognosy values. <strong>Methodology:</strong> To meet the objectives, the characteristics of these plants were explored by macroscopic, microscopic (light microscopy), and also by physio-chemical parameters. The physiochemical analysis was performed with air dried leaves and flowers of C. gigantea and C. procera. The collected samples were used for the quantitative determination of ash value (water solu

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Ørnsrud, R., E. J. Lock, C. N. Glover, and G. Flik. "Retinoic acid cross-talk with calcitriol activity in Atlantic salmon (Salmo salar)." Journal of Endocrinology 202, no. 3 (2009): 473–82. http://dx.doi.org/10.1677/joe-09-0199.

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Vitamins A (VA) and D (VD) are metabolised by vertebrates to bioactive retinoic acid (RA) and calcitriol (CTR). RA and CTR involvement in bone metabolism requires fine-tuned regulation of their synthesis and breakdown. In mammals antagonism of VA and VD is observed, but the mechanism of interaction is unknown. We investigated VA–VD interactions in Atlantic salmon (Salmo salar L.) following i.p. injection of RA and/or CTR. VA metabolites, CTR, calcium (Ca), magnesium (Mg) and phosphorus (P) were determined in plasma. Expression of bone matrix Gla protein (mgp), collagen 1 alpha2 chain (col1a2)

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El Baky, Hanaa H. Abd, Gamal S. El Baroty, and Enas M. Mostafa. "Optimization Growth of Spirulina (Arthrospira) Platensis in Photobioreactor Under Varied Nitrogen Concentration for Maximized Biomass, Carotenoids and Lipid Contents." Recent Patents on Food, Nutrition & Agriculture 11, no. 1 (2020): 40–48. http://dx.doi.org/10.2174/2212798410666181227125229.

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Aims and Background: Spirulina (Arthrospira) platensis (SP) microalgae were cultured in Zarrouk Medium (ZM), containing three nitrogen concentrations (N-limited, N-optimal and Nrich medium) in ten liter-photo-bioreactor (10 L PBR) for 15-days, in order to study changes in lipid compounds (total carotenoids and total lipids and their effect on fatty acid profile). Based on US patent, the yield of bioactive compounds (such as gamma-linolenic acid GLA, C18:3) extracted from microalgae biomass, mainly depends on the extraction processes (1). GLA has much attention with respect to its therapeutic p

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Russo, Rita, Antonio Colantuono, Sonia Di Gaetano, et al. "Phaseolus coccineus Seed: A Valued Resource for Bioactive Compounds Targeting Health and Tumor Cells." International Journal of Molecular Sciences 26, no. 5 (2025): 2189. https://doi.org/10.3390/ijms26052189.

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Human galectin-3 (Gal-3), a β-galactoside binding lectin through its Carbohydrate Recognition Domain (CRD), is implicated in a wide range of cellular functions and is involved in critical biological processes including pathogen recognition, immune response, inflammation and fibrosis. Recently, Gal-3 has gained increasing attention for its role in pathological conditions such as cancer, where it influences cancer growth and progression, inflammatory processes and oxidative stress, opening the search for potential inhibitors. In this context, several naturally derived molecules have attracted pa

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Mohanad, Jawad Kadhim, Fauzi Al-Rubaye Abeer, and Hadi Hameed Imad. "Determination of Bioactive Compounds of Methanolic Extract of Vitis vinifera Using GC-MS." International Journal of Toxicological and Pharmacological Research 9, no. 2 (2017): 113–26. https://doi.org/10.5281/zenodo.12725183.

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The objectives of this study were analysis of the secondary metabolite products and evaluation antibacterial activity. Bioactives are chemical compounds often referred to as secondary metabolites. Thirty three bioactive compounds were identified in the methanolic extract of <em>Vitis vinifera</em>. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC-MS analysis of <em>Vitis vinifera</em> revealed the existence of the Butanol , 2-nitro , α-D-Glucopyranoside , methyl 3,6-anhydro , Propanedioic aci

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Chang, Te-Sheng, Horng-Huey Ko, Tzi-Yuan Wang, Chun-Hsien Lee, and Jiumn-Yih Wu. "Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp." Fermentation 4, no. 4 (2018): 101. http://dx.doi.org/10.3390/fermentation4040101.

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The medicinal fungus Ganoderma lucidum contains many bioactive triterpenoids, ganoderic acid A (GAA) being one of the major ones. The present study explored the microbial biotransformation of GAA, isolating 283 strains of soil actinomycetes and determining their abilities to biotransform GAA with ultra-performance liquid chromatography analysis. One positive strain, AI 045, was selected to validate the biotransformation activity. The strain was identified as Streptomyces sp. based on the sequenced 16S rRNA gene. The produced compound obtained from the biotransformation of GAA was purified with

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Sawicka, Monika, Piotr Latocha, and Barbara Łata. "Peel to Flesh Bioactive Compounds Ratio Affect Apple Antioxidant Potential and Cultivar Functional Properties." Agriculture 13, no. 2 (2023): 478. http://dx.doi.org/10.3390/agriculture13020478.

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More than ten thousand apple cultivars with high variability in the quality traits and year-round availability place apples at the forefront of consumed fruits. Yet consumers and producers alike are still looking for new apple cultivars with specific quality attributes such as plant resistance to biotic and abiotic stresses as well as a high health-promoting potential. The model plants were three cultivars: a new ‘Chopin’ and an old ‘Granny Smith’, scab resistant cultivars with green peel, and a red-skinned cultivar ‘Gala Schniga’. Apple peel and flesh were analyzed separately during two growi

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Jiayi, Ma, Ingrid Melinda Gyalai, and Ferenc Lantos. "Investigation of water soluble sugar content and flavour evaluation of Gala Must, Royal Gala and Pinova apple varieties." Review on Agriculture and Rural Development 10, no. 1-2 (2022): 169–75. http://dx.doi.org/10.14232/rard.2021.1-2.169-175.

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Humankind has known regular consumption of apple since ancient times. The fruits contain several bioactive compounds for human. Nowadays, a lot of breeded varieties are in cultivation on the world. There are more than 7,500 known cultivars of apples, resulting in a wide range of desired characteristics. The Gala series apples are one of the most popular and common apples in Hungary in the 21st century. Gala Must was used as the subject of a study to compare the fruit quality of Hungarian Gala Must with Pinova and commercially available Royal Gala apples. By studying the data recorded and sampl

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Carlsen, Sandra C. K., Hans A. Pedersen, Niels H. Spliid, and Inge S. Fomsgaard. "Fate in Soil of Flavonoids Released from White Clover (Trifolium repensL.)." Applied and Environmental Soil Science 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/743413.

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White clover is frequently used as a leguminous cover crop, serving as green manure, and is also included with grasses in cattle feed mixtures. Numerous biological effects reported for clover cultivation have been attributed to the production of bioactive secondary metabolites. Thus far the presence in soil of bioactive secondary metabolites from clover has received limited attention. In this paper we examine for the first time the release of flavonoids both from field-grown white clover and from soil-incorporated white clover plants of flavonoids, as analyzed by LC-MS/MS. The dominant flavono

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Yasinta Moi, Maria, and Vinsensia Ulia Rita Sila. "AKTIVITAS ANTIBAKTERI BUNGA GALA-GALA MERAH (SESBANIA GRANDIFLORA L.) TERHADAP PERTUMBUHAN BAKTERI STAPHYLOCOCCUS EPIDERMIDIS." Jurnal Biogenerasi 9, no. 2 (2024): 1370–74. https://doi.org/10.30605/biogenerasi.v9i2.4370.

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Gala-gala is known to have many benefits as a medicinal plant that can cure some kinds of diseases. People in Timor Island, East Nusa Tenggara, use red gala-gala flowers as a source of vegetables and medicines to cure infectious diseases such as itching that causes abscesses. This study aims to find out the antibacterial activity of red gala-gala flower extract to inhibit the growth of Staphylococcus epidermidis bacteria. The method of antibacterial activity test used paper disk diffusion with concentrations of 20% and 40%. Antibacterial activities are shown by the presence of a halo zone arou

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Chang, Te-Sheng, Chien-Min Chiang, Tzi-Yuan Wang, et al. "One-Pot Bi-Enzymatic Cascade Synthesis of Novel Ganoderma Triterpenoid Saponins." Catalysts 11, no. 5 (2021): 580. http://dx.doi.org/10.3390/catal11050580.

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Ganoderma lucidum is a medicinal fungus whose numerous triterpenoids are its main bioactive constituents. Although hundreds of Ganoderma triterpenoids have been identified, Ganoderma triterpenoid glycosides, also named triterpenoid saponins, have been rarely found. Ganoderic acid A (GAA), a major Ganoderma triterpenoid, was synthetically cascaded to form GAA-15-O-β-glucopyranoside (GAA-15-G) by glycosyltransferase (BtGT_16345) from Bacillus thuringiensis GA A07 and subsequently biotransformed into a series of GAA glucosides by cyclodextrin glucanotransferase (Toruzyme® 3.0 L) from Thermoanaero

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Bhunia, Anirban, Oliver Schwardt, Heiko Gäthje та ін. "Consistent Bioactive Conformation of the Neu5Acα(2→3)Gal Epitope Upon Lectin Binding". ChemBioChem 9, № 18 (2008): 2941–45. http://dx.doi.org/10.1002/cbic.200800458.

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Yang, Li V., Caius G. Radu, Li Wang, Mireille Riedinger, and Owen N. Witte. "Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A." Blood 105, no. 3 (2005): 1127–34. http://dx.doi.org/10.1182/blood-2004-05-1916.

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Abstract G2A is a G-protein–coupled receptor (GPCR) involved in immune regulation. Previous studies have shown that lysophosphatidylcholine (LPC), a bioactive lipid associated with atherosclerosis and autoimmunity, acts through G2A to induce diverse biologic effects. Production of LPC during cell apoptosis serves as a chemotactic signal for macrophage recruitment. Here we demonstrate that macrophage chemotaxis to LPC is dependent on G2A function. Wild-type but not G2A-deficient mouse peritoneal macrophages migrated toward LPC. RNAi-mediated knockdown of G2A in J774A.1 macrophages abolished LPC

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Oliveira, Ellen A. de S., Juliana de A. S. Oliveira, Priscila R. Araújo, Frederico T. S. Tâmega, Ricardo Coutinho, and Angelica R. Soares. "Chemical diversity and antifouling activity of geniculate calcareous algae (Corallinales, Rhodophyta) from Brazil." PeerJ 11 (August 14, 2023): e15731. http://dx.doi.org/10.7717/peerj.15731.

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Marine biofouling is a natural process by which many organisms colonize and grow in submerged structures, causing serious economic consequences for the maritime industry. Geniculate calcareous algae (GCA; Corallinales, Rhodophyta) produce bioactive secondary metabolites and are a promise for new antifouling compounds. Here, we investigated the antifouling activity of four GCA species—Amphiroa beauvoisii, Jania sagittata (formerly Cheilosporum sagittatum), Jania crassa, and Jania prolifera (formerly Amphiroa flabellata)—from the Brazilian coast against macro- and microorganisms. Simultaneously,

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Ma, Zhe, Lin Peng, Wenhui Chu, Pan Wang та Yongqian Fu. "Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways". Molecules 28, № 1 (2023): 443. http://dx.doi.org/10.3390/molecules28010443.

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Osthole, a coumarin derivative, is found in several medicinal herbs. However, the protective effects of osthole against D-galactose (D-Gal)-induced liver injury still remain unclear. In this study, osthole treatment effectively reversed D-Gal-induced liver injury, according to the results of liver HE staining, and improved ALT and AST activities. Feeding with D-Gal significantly increased MDA content, and reduced the level or activity of SOD, CAT and GSH-Px, which were all alleviated by osthole intervention. Meanwhile, osthole treatment significantly inhibited the D-Gal-induced secretion of pr

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Li, Sumei, Min Yin, Peng Wang, et al. "Phenolic Compounds and Antioxidant Capacity Comparison of Wild-Type and Yellow-Leaf gl1 Mutant of Lagerstroemia indica." Plants 13, no. 2 (2024): 315. http://dx.doi.org/10.3390/plants13020315.

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Background: The yellow-leaf gl1 mutant of Lagerstroemia indica exhibits an altered phenylpropanoid metabolism pathway compared to wild-type (WT). However, details on the metabolites associated with leaf color variation, including color-specific metabolites with bioactive constituents, are not fully understood. Methods: Chemical and metabolomics approaches were used to compare metabolite composition and antioxidant capacity between the gl1 mutant and WT leaves. Results: The mutant exhibited an irregular xylem structure with a significantly lower phenolic polymer lignin content and higher solubl

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Arjun, Karmakar. "Pharmacognostic and Conservational Overview of Swertia chirata Buch.- Ham. ex Wall., A Critically Endangered Himalayan Herb." Journal of Food Science and Nutrition Therapy 2, no. 1 (2016): 015–18. https://doi.org/10.17352/jfsnt.000004.

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<strong>Background</strong>: Swertia chirata Buch.-Ham. ex Wall. is an endangered medicinal herb native to the temperate Himalayan region. The species holds immense ethnobotanical importance in India, Nepal, Bangladesh and Bhutan. The herb is known to host a plethora of bioactive phytoconstituents that imbue it with a wide variety of medicinal properties. Modern research has proven that extracts of S. chirata possess antioxidative, anticarcinogenic, antimalarial, anti-infl ammatory and hypoglycaemic activities. The present article aims at highlighting the medicinal importance of S. chirata alo

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Puschmann, Till B., Carl Zandén, Yolanda De Pablo, et al. "Bioactive 3D cell culture system minimizes cellular stress and maintains thein vivo-like morphological complexity of astroglial cells." Glia 61, no. 3 (2013): 432–40. http://dx.doi.org/10.1002/glia.22446.

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G, Tamaddon. "Apoptosis Induction of Ganoderic Acid-A by Downregulating miR- 125b and miR-365a-3p in Nalm-6 cells." Haematology International Journal 6, no. 2 (2022): 1–10. http://dx.doi.org/10.23880/hij-16000201.

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Acute lymphoblastic leukemia is the most common leukemia in children, which is associated with a high relapse rate despite prevalent therapies. Ganoderic acid-A (GAA) is one of the bioactive compounds of Ganoderma lucidum, which possesses potential antileukemic properties. This study aimed to investigate the effect of the GAA extract on the expression of microRNA and the apoptosis induction in the BCP-ALL cell line. In this case-control study, NALM-6 Cells were treated with the GAA extract and L-asparaginase separately. The cell viability and apoptosis rates were examined using MTT and flow cy

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Chang, Te-Sheng, Chien-Min Chiang, Yu-Han Kao, Jiumn-Yih Wu, Yu-Wei Wu, and Tzi-Yuan Wang. "A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis." Molecules 24, no. 19 (2019): 3457. http://dx.doi.org/10.3390/molecules24193457.

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Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American type culture collection) 6633 strain could biotransform GAA into compound (1), GAA-15-O-β-glucoside, and compound (2). Even though we identified two glycosyltransferases (GT) to catalyze the synthesis of GAA-15-O-β-glucoside, the chemical structure of compound (2) and its corresponding enzyme remain elusive. In the present study, we identified BsGT110, a GT from the same B. subtilis strain, for the biotransformation of GAA

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Aureli, Anna, Manuela Del Cornò, Beatrice Marziani, Sandra Gessani, and Lucia Conti. "Highlights on the Role of Galectin-3 in Colorectal Cancer and the Preventive/Therapeutic Potential of Food-Derived Inhibitors." Cancers 15, no. 1 (2022): 52. http://dx.doi.org/10.3390/cancers15010052.

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Colorectal cancer (CRC) is a leading cause of death worldwide. Despite advances in surgical and therapeutic management, tumor metastases and resistance to therapy still represent major hurdles. CRC risk is highly modifiable by lifestyle factors, including diet, which strongly influences both cancer incidence and related mortality. Galectin-3 (Gal-3) is a multifaceted protein involved in multiple pathophysiological pathways underlying chronic inflammation and cancer. Its versatility is given by the ability to participate in a wide range of tumor-promoting processes, including cell–cell/cell–mat

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Falk, Shaun P., Andrew T. Ulijasz, and Bernard Weisblum. "Differential Assay for High-Throughput Screening of Antibacterial Compounds." Journal of Biomolecular Screening 12, no. 8 (2007): 1102–8. http://dx.doi.org/10.1177/1087057107308161.

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The previously described Bacillus subtilis reporter strain BAU-102 is capable of detecting cell wall synthesis inhibitors that act at all stages of the cell wall synthesis pathway. In addition, this strain is capable of detecting compounds with hydrophobic/ surfactant activity and alternative mechanisms of cell wall disruption. BAU-102 sequesters preformed β-gal in the periplasm, suggesting leakage of β-gal as the means by which this assay detects compound activities. A model is proposed according to which β-gal release by BAU-102 reflects activation of pathways leading to autolysis. The autho

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Odun-Ayo, Frederick, and Lalini Reddy. "Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2." J 4, no. 4 (2021): 824–37. http://dx.doi.org/10.3390/j4040056.

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Modified pectin (MP) is a bioactive complex polysaccharide that is broken down into smaller fragments of units and used as an oral dietary supplement for cell proliferation. MP is safe and non-toxic with promising therapeutic properties with regard to targeting galectin-3 (GAL-3) toward the prevention and inhibition of viral infections through the modulation of the immune response and anti-inflammatory cytokine effects. This effect of MP as a GAL-3 antagonism, which has shown benefits in preclinical and clinical models, may be of relevance to the progression of the novel severe acute respirato

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Chen, Sihan, Ying Zong, Jianming Li, Zhongmei He, and Rui Du. "Protective Effects of Deer Antler Peptides on D-Galactose-Induced Brain Injury." Nutrients 17, no. 14 (2025): 2306. https://doi.org/10.3390/nu17142306.

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Background/Objectives: The aim of this study was to investigate the role and potential mechanism of deer antler peptides (DAP) in D-galactose (D-gal)-induced brain injury. Methods: In the in vivo study, C57BL/6J mice were intraperitoneally injected with 400 mg/kg D-gal and gavaged with DAP (50 and 200 mg/kg) for 5 weeks. In vitro studies, D-gal (30 μg/mL) induced senescent BV2 cells were used for further research. Results: DAP increased the expression of BDNF and VEGF in the brain tissue of aging mice, reduced the levels of oxidative stress and inflammatory factors in serum, and decreased the

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Mendes, Luana Guabiraba, Francisco Rogênio da Silva Mendes, Roselayne Ferro Furtado, et al. "Use of cashew gum combined with galactomannan for encapsulation of Rosmarinus officinalis essential oil." Journal of Environmental Analysis and Progress 5, no. 4 (2020): 369–80. http://dx.doi.org/10.24221/jeap.5.4.2020.2748.369-380.

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Encapsulating matrices are important to maintain the properties, promote the low and controlled release, and avoid these bioactive compounds' undesirable reactions. This study's objective was to evaluate cashew gum (CG) use combined with galactomannan (GAL) in the rosemary essential oil encapsulation by atomization. During the emulsification, the polysaccharides were crosslinked with sodium trimetaphosphate. The particles obtained after encapsulation were evaluated for moisture, solubility, particle size, encapsulation efficiency, morphology, antimicrobial activity, and chemical composition of

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Gustavo Sganzerla, William, Mayeve Didomenico Melo, Jocleita Peruzzo Ferrareze, Ana Paula de Lima Veeck, Paula Iaschitzki Ferreira, and César Luis Girardi. "Postharvest treatment with 1-MCP in apple ‘Gala’ mutants: physicochemical characterization, bioactive compounds and antioxidant activity." Communications in Plant Sciences 8, no. 1 (2018): 40–47. http://dx.doi.org/10.26814/cps2018006.

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Aladaileh, Abukhalil, Saghir, et al. "Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity." Biomolecules 9, no. 8 (2019): 346. http://dx.doi.org/10.3390/biom9080346.

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Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive flavonoid with promising biological activities. This study investigated the hepatoprotective effect of Gal in CP-induced rats. Rats received Gal (15, 30 and 60 mg/kg/day) for 15 days followed by a single dose of CP at day 16. Cyclophosphamide triggered liver injury characterized by elevated serum transaminases, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), and histopathological manifestations. Increased hepa

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Julien Armel, ASSIENE AGAMOU, DJEUKEU ASONGNI William, ASSIENE OYONG Damase Serge, et al. "Influence of particle size fraction and bioactive compound contents on the biological activities of Solanum torvum L. leaf powder extracts." Journal of Experimental Biology and Agricultural Sciences 12, no. 2 (2024): 203–17. http://dx.doi.org/10.18006/2024.12(2).203.217.

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This study investigates the bioactive compound content and biological activities of raw powder extracts and particle size fractions from Solanum torvum leaves. The leaves, harvested from Douala, were processed into powders and subsequently divided into different fractions. Methanolic extracts of these powders were analyzed for their content of bioactive compounds (total polyphenols, total flavonoids, and condensed tannins), antioxidant (DPPH, ABTS, FRAP assays), and antimicrobial (bacterial and fungal) activities. The particle size fraction of 250-400 µm constitutes the largest proportion (33.

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Walkowiak-Tomczak, Dorota, Natalia Idaszewska, Grzegorz P. Łysiak, and Krzysztof Bieńczak. "The Effect of Mechanical Vibration during Transport under Model Conditions on the Shelf-Life, Quality and Physico-Chemical Parameters of Four Apple Cultivars." Agronomy 11, no. 1 (2021): 81. http://dx.doi.org/10.3390/agronomy11010081.

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The study assessed the changes in the quality and physical and chemical parameters of apples of four cultivars (‘Gala’, ‘Idared’, ‘Topaz’, ‘Red Prince’) subjected to mechanical vibration during transport under model conditions and after storage (shelf-life). Quality changes in apples were evaluated based on skin and flesh colour, total soluble solids, dry matter, firmness, titratable acidity, pH value, total polyphenol content, and antioxidant capacity. The vibration applied at a frequency of 28 Hz caused changes in the above parameters, which were visible also after storage and depended on th

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Miller, Michelle C., Irina V. Nesmelova, Vladimir A. Daragan, et al. "Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function." Biochemical Journal 477, no. 17 (2020): 3147–65. http://dx.doi.org/10.1042/bcj20200499.

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Human galectin-7 (Gal-7; also termed p53-induced gene 1 product) is a multifunctional effector by productive pairing with distinct glycoconjugates and protein counter-receptors in the cytoplasm and nucleus, as well as on the cell surface. Its structural analysis by NMR spectroscopy detected doubling of a set of particular resonances, an indicator of Gal-7 existing in two conformational states in slow exchange on the chemical shift time scale. Structural positioning of this set of amino acids around the P4 residue and loss of this phenomenon in the bioactive P4L mutant indicated cis–trans isome

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Khawaja, Ghada, Youmna El-Orfali, Aya Shoujaa, and Sonia Abou Najem. "Galangin: A Promising Flavonoid for the Treatment of Rheumatoid Arthritis—Mechanisms, Evidence, and Therapeutic Potential." Pharmaceuticals 17, no. 7 (2024): 963. http://dx.doi.org/10.3390/ph17070963.

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Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation and damage. Oxidative stress plays a critical role in the onset and progression of RA, significantly contributing to the disease’s symptoms. The complex nature of RA and the role of oxidative stress make it particularly challenging to treat effectively. This article presents a comprehensive review of RA’s development, progression, and the emergence of novel treatments, introducing Galangin (GAL), a natural flavonoid compound sourced from various plants, as a promising candidate. The bioact

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Shiwakoti, Saugat, Deepak Adhikari, Jeong Pyo Lee, et al. "Prevention of Fine Dust-Induced Vascular Senescence by Humulus lupulus Extract and Its Major Bioactive Compounds." Antioxidants 9, no. 12 (2020): 1243. http://dx.doi.org/10.3390/antiox9121243.

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Both short- and long-term exposure to fine dust (FD) from air pollution has been linked to various cardiovascular diseases (CVDs). Endothelial cell (EC) senescence is an important risk factor for CVDs, and recent evidence suggests that FD-induced premature EC senescence increases oxidative stress levels. Hop plant (Humulus lupulus) is a very rich source of polyphenols known to have nutritional and therapeutic properties, including antioxidant behavior. The aims of this study were to evaluate whether Humulus lupulus extract prevents FD-induced vascular senescence and dysfunction and, if so, to

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Chung, Nguyễn Thành, Lưu Đức Huy, Hồ Văn Khánh та ін. "ISOLATION AND BIOACTIVE ASSAY OF γ-ORYZANOL FROM RICE BRAN (ORYZA SATIVA)". TNU Journal of Science and Technology 229, № 05 (2024): 153–59. http://dx.doi.org/10.34238/tnu-jst.7466.

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Việt Nam hiện nay là nước xuất khẩu gạo lớn thứ hai trên thế giới. Cám gạo là sản phẩm phụ của quá trình xay xát gạo. Nó chiếm khoảng 14% trọng lượng hạt thóc. Trước đây, cám gạo chỉ được dùng làm thức ăn cho gia súc. Điều này mang lại giá trị kinh tế rất thấp. Gần đây, một lượng nhỏ cám gạo được sử dụng trong mỹ phẩm và thực phẩm bằng cách sử dụng nguyên cám hoặc giàu cám. Để nâng cao giá trị và ứng dụng của cám gạo, chúng tôi tiến hành nghiên cứu thành phần cám gạo của giống lúa Thái Bình. Dầu cám gạo được chiết suất bằng cách sử dụng ethyl acetate. Từ đó, một hợp chất γ-oryzanol là 24-methy

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Seweryn, Ewa, Emilia Królewicz, Kamilla Stach, and Irena Kustrzeba-Wójcicka. "Nutritional and allergenic properties of hen eggs." Postępy Higieny i Medycyny Doświadczalnej 72 (April 6, 2018): 205–14. http://dx.doi.org/10.5604/01.3001.0011.7339.

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Chicken eggs, along with cow milk, are the most important source of proteins and other valuable nutrients that are introduced to a baby`s diet. Certain components of eggs, besides nutritional, also have other biological functions. Both proteins, phospholipids or carotenoids, are bioactive components which affect the physiological processes in the human body. Regular consumption of chicken eggs rich in substances with antibacterial, anti-inflammatory, immunomodulatory and antioxidant properties may contribute to reducing the incidence of certain lifestyle diseases. Ovomucoid, as a glycoprotein

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Gottlieb, Otto R., Maria Renata de M. B. Borin, and Nei Regis S. de Brito. "Quantitative chemobiology." Pure and Applied Chemistry 73, no. 3 (2001): 583–88. http://dx.doi.org/10.1351/pac200173030583.

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One of the mysteries of man's contact with nature concerns the question why shamanism and science so often lead to consistent results in the search for useful natural products. To find clues toward an answer via a coherent chemobiological language, structural and functional information is taken into account. The functional information, given by ethnobotanical codes based on traditional knowledge (via number of useful dicotyledon species), is confronted with the structural information, given by metabolic codes based on micromolecular diversification (via number of occurrences in dicotyledons).

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Kim, Sun-Hee, Woo-Soo Jeong, So-Young Kim, and Soo-Hwan Yeo. "Quality and Functional Characterization of Acetic Acid Bacteria Isolated from Farm-Produced Fruit Vinegars." Fermentation 9, no. 5 (2023): 447. http://dx.doi.org/10.3390/fermentation9050447.

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Acetic acid bacteria (AAB) form a bacterial film on the surface of alcoholic solutions and ferment ethanol to acetic acid while also producing bioactive compounds. To discover functional AAB for industrial use, we isolated and selected strains from farm-produced vinegars using a CaCO3-containing medium. The seven isolated strains belonged to Acetobacter cerevisiae and Acetobacter pasteurianus. These strains were tolerant to ethanol concentrations up to 12% (v/v). Acidification was seen for GHA 7, GYA 23, JGB 21-17, and GHA 20 strains at a growth temperature of 40 °C. The seven AAB isolates had

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Kusnandar, Feri, Asep Safari, and Elvira Syamsir. "Perubahan Karakteristik Fisik Model Minuman Biji Chia Akibat Proses Pemanasan, Perubahan pH, Penambahan Gula dan Garam." Jurnal Mutu Pangan : Indonesian Journal of Food Quality 7, no. 1 (2020): 21–29. http://dx.doi.org/10.29244/jmpi.2020.7.1.21.

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Chia seed is rich in protein, lipid, and carbohydrates as well as bioactive compounds such as phenol. The outer layer of chia seed is made of insoluble polysaccharide (mucilage) which is able to absorb water. For this reason, chia seed is potentially used as a functional ingredient in beverages. This study aimed to evaluate the changes of physical characteristics of chia seeds in beverage models (water absorption capacity or WAC and capsule thickness of chia seeds, and viscosity of beverage model) as the effect of heating temperatures (70, 90oC) and heating times (1, 2 hours), pH changes (3, 5

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Fernandes, Lisete, Pedro B. Tavares, João Siopa, Carla Gonçalves, and Fernando M. Nunes. "Comparative Analysis of the Physicochemical Properties of Fresh, Solar-Dried, Oven-Dried and Commercial Royal Gala Apple Snacks." Applied Sciences 15, no. 12 (2025): 6711. https://doi.org/10.3390/app15126711.

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This study compares the physicochemical properties of Royal Gala apple snacks fresh and processed using different methods: solar-dried (SD), oven-dried at 65 °C (OD65°) and 85 °C (OD85°) and two commercial brands (CC—commercial apple C and CF—commercial apple F). Evaluated parameters included color, microstructure, acidity, sugar content, phenolic compounds, antioxidant activity, and the presence of heat-induced compounds such as 5-hydroxymethylfurfural (5-HMF) and acrylamide. Commercial samples showed more pronounced color changes and a denser microstructure, with higher browning index (BI) v

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Chen, Xiaochun, Zhiying Wei, Xiaoying Mo, et al. "Structural Characterization and Anti-Ultraviolet Radiation Damage Activity of Polysaccharides from Helianthus annuus (Sunflower) Receptacles." Molecules 30, no. 14 (2025): 2943. https://doi.org/10.3390/molecules30142943.

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Helianthus annuus L. (H. annuus) receptacles, a major agricultural by-product generated during seed processing, are currently underutilized. This study aimed to explore the valorization potential of this by-product by extracting H. annuus receptacles total polysaccharides (HRTP) and characterizing their potential as natural ingredients in ultraviolet (UV)-protective cosmetics. A new purified polysaccharide named H. annuus receptacles polysaccharide-1 (HRP-1) was isolated, likely exhibiting a backbone of alternating →4)-α-D-GalA-(1→ and →4)-α-D-GalA(6-OCH3)-(1→ units, with a weight-average mole

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Park, Yoonseong, Donghun Kim, Gunavanthi Boorgula, et al. "Alpha-Gal and Cross-Reactive Carbohydrate Determinants in the N-Glycans of Salivary Glands in the Lone Star Tick, Amblyomma americanum." Vaccines 8, no. 1 (2020): 18. http://dx.doi.org/10.3390/vaccines8010018.

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Ticks are important ectoparasites and vectors of numerous human and animal pathogens. Ticks secrete saliva that contains various bioactive materials to evade the host defense system, and often facilitates the pathogen transmission. In addition, the Lone star tick saliva is thought to be the sensitizer in red meat allergy that is characterized by an allergic reaction to glycan moieties carrying terminal galactose-alpha-1,3-galactose (aGal). To assess N-glycome of Amblyomma americanum, we examined the N-glycan structures in male and female salivary glands at three different feeding stages and in

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Hwang, Ki Cheol, Hyun Young Shin, Woo Jung Kim, Mi Suk Seo, and Hoon Kim. "Effects of a High-Molecular-Weight Polysaccharides Isolated from Korean Persimmon on the Antioxidant, Anti-Inflammatory, and Antiwrinkle Activity." Molecules 26, no. 6 (2021): 1600. http://dx.doi.org/10.3390/molecules26061600.

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Persimmon (Diospyros kaki), a familiar and widespread fruit worldwide, is known to exhibit several physiological effects because of the presence of pharmacologically active compounds called phytochemicals. However, its high-molecular-weight compounds, particularly polysaccharides, have not been extensively studied. In this study, D. kaki extract (DK) was fractionated into low- and high-molecular-weight fractions (DK-L and DK-H, respectively) through ethanol fractionation, and their effects on antioxidant, anti-inflammatory, and antiwrinkle activities were investigated by an in vitro system. DK

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