Academic literature on the topic 'Bioactive Glass, Bone Cement, Antibacterial'

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Journal articles on the topic "Bioactive Glass, Bone Cement, Antibacterial"

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Verné, Enrica, Filippo Foroni, Giovanni Lucchetta, and Marta Miola. "Antibacterial and Bioactive Composite Bone Cements." Current Materials Science 12, no. 2 (March 3, 2020): 144–53. http://dx.doi.org/10.2174/1874464812666190819143740.

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Background:: Peri-prosthetic infections are characterized by high resistance to systemic antibiotic therapy. In this work, commercial PMMA-based bone cement has been loaded with a bioactive glass doped with silver ions, with the purpose to prepare composite bone cement containing a single inorganic phase with both bioactive and antibacterial properties, able to prevent bacterial contamination. Methods:: The glass distribution in the polymeric matrix, the composites radio-opacity, the bending strength and modulus, the morphology of the fracture surfaces, the bioactivity in Simulated Body Fluid (SBF) and the antibacterial effect were evaluated. The glass particles dispersion in the polymeric matrix and their exposition on the polymer surface have been assessed by morphological and compositional characterizations via Scanning Electron Microscopy (SEM) and Energy Dispersion Spectroscopy (EDS). Results:: The introduction of the silver-doped bioactive glass allowed imparting an intrinsic radio-opacity to the cement. The bending strength and modulus were influenced by the glass preparation, amount and grain-size. The polymeric matrix did not affect the composite ability to induce hydroxyapatite precipitation on its surface (bioactivity). Moreover, antibacterial test (inhibition halo evaluation) revealed a significant antibacterial effect toward S. aureus, Bacillus, E. coli and C. albicans strains. Conclusion:: The obtained results motivate further investigations and future in vivo tests.
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Russo, Teresa, Roberto De Santis, Antonio Gloria, Katia Barbaro, Annalisa Altigeri, Inna V. Fadeeva, and Julietta V. Rau. "Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles." Polymers 12, no. 1 (December 25, 2019): 37. http://dx.doi.org/10.3390/polym12010037.

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Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, and repair or regeneration of large cranial defects is particularly challenging from both a functional and aesthetic point of view. PMMA-based bone cement are the most widely biomaterials adopted in the field, with at least four different surgical approaches. Modifications for improving biological and mechanical functions of PMMA-based bone cement have been suggested. To this aim, the inclusion of antibiotics to prevent infection has been shown to provide a reduction of mechanical properties in bending. Therefore, the development of novel antibacterial active agents to overcome issues related to mechanical properties and bacterial resistance to antibiotics is still encouraged. In this context, mechanical, biological, and antibacterial feature against P. aeruginosa and S. aureus bacterial strains of surgical PMMA cement modified with BG and recently developed Cu-TCP bioactive particles have been highlighted.
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Miola, Marta, Giacomo Fucale, Giovanni Maina, and Enrica Verné. "Antibacterial and bioactive composite bone cements containing surface silver-doped glass particles." Biomedical Materials 10, no. 5 (October 20, 2015): 055014. http://dx.doi.org/10.1088/1748-6041/10/5/055014.

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Miola, Marta, Giacomo Fucale, Giovanni Maina, and Enrica Verné. "Composites bone cements with different viscosities loaded with a bioactive and antibacterial glass." Journal of Materials Science 52, no. 9 (January 17, 2017): 5133–46. http://dx.doi.org/10.1007/s10853-017-0750-1.

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Miola, Marta, Andrea Cochis, Ajay Kumar, Carla Arciola, Lia Rimondini, and Enrica Verné. "Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization." Materials 11, no. 6 (June 6, 2018): 961. http://dx.doi.org/10.3390/ma11060961.

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Hasan, Raquib, Kambri Schaner, Pranothi Mulinti, and Amanda Brooks. "A Bioglass-Based Antibiotic (Vancomycin) Releasing Bone Void Filling Putty to Treat Osteomyelitis and Aid Bone Healing." International Journal of Molecular Sciences 22, no. 14 (July 20, 2021): 7736. http://dx.doi.org/10.3390/ijms22147736.

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While the infection rate after primary total joint replacements (TJR) sits at 1–2%, for trauma-related surgery, it can be as high as 3.6 to 21.2% based on the type of trauma; the risk of reinfection after revision surgery is even higher. Current treatments with antibiotic-releasing PMMA-based bone cement/ beads and/or systemic antibiotic after surgical debridement do not provide effective treatment due to fluctuating antibiotic levels at the site of infection, leading to insufficient local antibiotic concentration. In addition, non-biodegradable PMMA does not support bone regrowth in the debrided void spaces and often must be removed in an additional surgery. Here, we report a bioactive glass or bioglass (BG) substrate-based biodegradable, easy to fabricate “press fitting” antibiotic-releasing bone void filling (ABVF-BG) putty to provide effective local antibiotic release at the site of infection along with support for bone regeneration. The ABVF-BG putty formulation had homogenously distributed BG particles, a porous structure, and showed putty-like ease of handling. Furthermore, the ABVF-BG putty demonstrated in vitro antibacterial activity for up to 6 weeks. Finally, the ABVF-BG putty was biodegradable in vivo and showed 100% bacterial eradication (as shown by bacterial cell counts) in the treatment group, which received ABVF-BG putty, compared to the infection control group, where all the rats had a high bacterial load (4.63 × 106 ± 7.9 × 105 CFU/gram bone) and sustained osteomyelitis. The ABVF-BG putty also supported bone growth in the void space as indicated by a combination of histology, µCT, and X-ray imaging. The potential for simultaneous infection treatment and bone healing using the developed BG-based ABVF-BG putty is promising as an alternative treatment option for osteomyelitis.
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Kokubo, Tadashi, Satoru Yoshihara, Naomi Nishimura, Takao Yamamuro, and Takashi Nakamura. "Bioactive Bone Cement Based on CaOSiO2P2O5 Glass." Journal of the American Ceramic Society 74, no. 7 (July 1991): 1739–41. http://dx.doi.org/10.1111/j.1151-2916.1991.tb07176.x.

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Kontonasaki, Eleana, Lambrini Papadopoulou, T. Zorba, E. Siarampi, K. Papazisis, A. Kortsaris, Konstantinos M. Paraskevopoulos, and Petros Koidis. "Effect of Bioactive Glass/Cement Weight Ratio on Bioactivity and Biocompatibility of a Bioactive Glass Modified Glass Ionomer Cement." Key Engineering Materials 309-311 (May 2006): 877–80. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.877.

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The bioactivity of a glass ionomer luting cement (Ketac®-cem, ESPE, Germany), which was modified by Bioglass® (PerioGlas® Synthetic Bone Graft Particulate, US Biomaterials) in different bioglass/powder weight ratios, and the biocompatibility of the produced mixtures were evaluated in this study using different cell lines. The incorporation of Bioglass® in the cement structure resulted in the formation of sparsely located biological apatite aggregations. However, although Bioglass® incorporation seemed to enhance cell proliferation, the materials became eventually brittle and highly soluble depending on Bioglass® amount.
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Lim, Hyoung-Bong, and Cheol-Young Kim. "Setting and Hydroxyapatite Formation of Bioactive Glass Bone Cement." Journal of the Korean Ceramic Society 42, no. 11 (November 1, 2005): 770–76. http://dx.doi.org/10.4191/kcers.2005.42.11.770.

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Fu, Qiang, Nai Zhou, Wenhai Huang, Deping Wang, Liying Zhang, and Haifeng Li. "Preparation and characterization of a novel bioactive bone cement: Glass based nanoscale hydroxyapatite bone cement." Journal of Materials Science: Materials in Medicine 15, no. 12 (December 2004): 1333–38. http://dx.doi.org/10.1007/s10856-004-5742-4.

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Dissertations / Theses on the topic "Bioactive Glass, Bone Cement, Antibacterial"

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Sanders, Lawrence Matthew. "The Synthesis & Characterization of an Antibacterial Bioactive Glass Suitable as a Bone Void Substitute." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo15447109069978.

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Chen, Song. "Glass Ionomer Cements with Improved Bioactive and Antibacterial Properties." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301924.

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Dental restorative cements are placed in a harsh oral environment where they are subjected to thermal shock, chemical degradation, and repeating masticatory force. The ideal restorative dental cements should have superior mechanical properties, chemical stability, aesthetic, good handling properties, biocompatibility, antibacterial properties, and preferably bioactivity. This thesis presents research on dental restorative cements with enhanced properties. The overall aim was to increase the bioactivity and antibacterial properties of dental restorative cements without affecting their other properties. The effect from adding calcium silicate to glass ionomer cement (GIC) was investigated. The results showed that calcium silicate could increase the bioactivity and reduce the cytotoxicity of conventional glass ionomer cement without compromising its setting and mechanical properties. Hydroxyapatite (HA) with a high aspect ratio and thin nacreous-layered monetite sheets were also synthesized. Nano HA particles with an aspect ratio of 50 can be synthesized by both precipitation and hydrothermal methods. The aspect ratio was controlled via the pH of reaction medium. Thin nacreous-layered monetite sheets were synthesized through a self-assembly process in the presence of an amine based cationic quaternary surfactant. Temperature, pH, and presence of surfactant played essential roles in forming the nacreous-layered monetite sheets. Then the effect from adding silver doped HA and monetite particles was investigated. The results showed that the antibacterial properties of GIC could be increased by incorporating silver doped HA and monetite particles. Further examination showed that the pH change, F- ion release, and concentration of released Ag+ ions were not responsible for the improved antibacterial properties. The quasi-static strengths and compressive fatigue limits of four types of the most commonly used dental restorations were evaluated. In our study, resin modified GIC and resin-based composite showed superior static compressive strength and fatigue limits compared to conventional GIC. The static compressive strength of dental cements increased with the aging time. However, aging had no effect on the compressive fatigue limit of resin modified GIC and resin-based composite. The compressive fatigue limit of conventional GIC even showed a drastic decrease after aging.
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Cancian, Daniela Cristina Joannitti [UNESP]. "Utilização de enxerto ósseo autógeno, biovidros e cimento de fosfato de cálcio em defeitos ósseos criados cirurgicamente em mandíbulas de macacos Cebus apella. Estudo histológico." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/104756.

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Made available in DSpace on 2014-06-11T19:33:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-04-04Bitstream added on 2014-06-13T20:25:02Z : No. of bitstreams: 1 cancian_dcj_dr_arafo.pdf: 701669 bytes, checksum: fd8aefd8d48f51c10e40c62ed9f6db8a (MD5)
A proposição deste estudo foi avaliar histologicamente a efetividade do PerioGlass, Fillerbone e Bone Source no preenchimento de cavidades ósseas cirurgicamente criadas em mandíbulas de macacos adultos jovens Cebus apella. Foram criadas duas cavidades transfixantes de 5mm de diâmetro nos ângulos mandibulares. Os defeitos ósseos foram preenchidos aleatoriamente e os grupo divididos da seguinte forma: Grupo I - cavidades preenchidas com osso cortiço-medular autógeno de tíbia; Grupo II - cavidades preenchidas com cimento de fosfato de cálcio (Bone Source); Grupo III - cavidades preenchidas com vidro bioativo (Fillerbone); Grupo IV - cavidades preenchidas com vidro bioativo (PerioGlass). Após 180 dias os animais foram sacrificados, as peças removidas e processadas para obtenção de cortes histológicos. A análise histológica dos resultados demonstrou que a utilização de enxerto ósseo autógeno permitiu reparação total do defeito ósseo; os materiais Fillerbone e PerioGlass permitiram reparo total dos defeitos com íntimo contaato dos grânulos dos materiais com o tecido ósseo neoformado; o material Boné Source não permitiu reparação do defeito ósseo ocorrendo preenchimento do defeito por tecido conjuntivo fibroso e foi em grande parte reabsorvido.
The present study evaluated histological results of filling with autogenous bone, PerioGlass, Fillerbone and Bone Source in bone cavities surgically created in mandible of Cebus apella Monkeys. The surgical cavities were prepared through both mandibular cortices, with a diameter of 5mm, inthe mandibular angle region. The cavities were randomized filled and the groups divided according to the material employed as follow: Group I - Filled with tibial autogenous corticocancellous bone; Group II - Filled with calcium phosphate cement (Bone Source); Group III - Filled with bioactive glass (Fillerbone); Group IV - Filled with bioactive glass (PerioGlass). After 180 days the animals were sacrificed and the specimens followed routine laboratory procedures for hematoxilin/eosin staining and histological evaluation. The histological analysis showed that the autogenous bone allowed total repair of the bone defects; Fillerbone and PerioGlass allowed total repair of the defects with intimate contact of the remaining granules and newly formed bone; Bone Source did not allow bone formation with filling of the defects by connective fibrous tissue and the material was almost totally ressorbed.
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Cancian, Daniela Cristina Joannitti. "Utilização de enxerto ósseo autógeno, biovidros e cimento de fosfato de cálcio em defeitos ósseos criados cirurgicamente em mandíbulas de macacos Cebus apella. Estudo histológico /." Araraquara : [s.n.], 2002. http://hdl.handle.net/11449/104756.

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Orientador: Rosemary Adriana Chiérici Marcantonio
Banca: Luis Carlos Spolidorio
Banca: Marisa Aparecida Cabrini Gabrielli
Banca: Idelmo Rangel Garcia Junior
Banca: Marcio Zaffalon Casati
Resumo: A proposição deste estudo foi avaliar histologicamente a efetividade do PerioGlass, Fillerbone e Bone Source no preenchimento de cavidades ósseas cirurgicamente criadas em mandíbulas de macacos adultos jovens Cebus apella. Foram criadas duas cavidades transfixantes de 5mm de diâmetro nos ângulos mandibulares. Os defeitos ósseos foram preenchidos aleatoriamente e os grupo divididos da seguinte forma: Grupo I - cavidades preenchidas com osso cortiço-medular autógeno de tíbia; Grupo II - cavidades preenchidas com cimento de fosfato de cálcio (Bone Source); Grupo III - cavidades preenchidas com vidro bioativo (Fillerbone); Grupo IV - cavidades preenchidas com vidro bioativo (PerioGlass). Após 180 dias os animais foram sacrificados, as peças removidas e processadas para obtenção de cortes histológicos. A análise histológica dos resultados demonstrou que a utilização de enxerto ósseo autógeno permitiu reparação total do defeito ósseo; os materiais Fillerbone e PerioGlass permitiram reparo total dos defeitos com íntimo contaato dos grânulos dos materiais com o tecido ósseo neoformado; o material Boné Source não permitiu reparação do defeito ósseo ocorrendo preenchimento do defeito por tecido conjuntivo fibroso e foi em grande parte reabsorvido.
Abstract: The present study evaluated histological results of filling with autogenous bone, PerioGlass, Fillerbone and Bone Source in bone cavities surgically created in mandible of Cebus apella Monkeys. The surgical cavities were prepared through both mandibular cortices, with a diameter of 5mm, inthe mandibular angle region. The cavities were randomized filled and the groups divided according to the material employed as follow: Group I - Filled with tibial autogenous corticocancellous bone; Group II - Filled with calcium phosphate cement (Bone Source); Group III - Filled with bioactive glass (Fillerbone); Group IV - Filled with bioactive glass (PerioGlass). After 180 days the animals were sacrificed and the specimens followed routine laboratory procedures for hematoxilin/eosin staining and histological evaluation. The histological analysis showed that the autogenous bone allowed total repair of the bone defects; Fillerbone and PerioGlass allowed total repair of the defects with intimate contact of the remaining granules and newly formed bone; Bone Source did not allow bone formation with filling of the defects by connective fibrous tissue and the material was almost totally ressorbed.
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Book chapters on the topic "Bioactive Glass, Bone Cement, Antibacterial"

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Lindfors, Nina, Jan Geurts, Lorenzo Drago, J. J. Arts, Vesa Juutilainen, Pekka Hyvönen, Arnold J. Suda, et al. "Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections – A Multinational Study." In Advances in Experimental Medicine and Biology, 81–92. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/5584_2016_156.

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Lindfors, Nina, Jan Geurts, Lorenzo Drago, J. J. Arts, Vesa Juutilainen, Pekka Hyvönen, Arnold J. Suda, et al. "Erratum: Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections – A Multinational Study." In Advances in Experimental Medicine and Biology, 115–16. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/5584_2017_13.

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Shinzato, S., Takashi Nakamura, Koji Goto, and Tadashi Kokubo. "Bioactive Bone Cement Composed of Crystallized Glass Beads and PMMA: Evaluation of Degradation by an In Vivo Aging Test." In Bioceramics 17, 133–36. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.133.

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Nishimura, N., T. Yamamuro, T. Nakamura, Y. Taguchi, T. Kokubo, and S. Yoshihara. "A Novel Bioactive Bone Cement based on CaO-SiO2-P2O5-CaF2 Glass." In Bioceramics, 295–99. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-7506-0269-3.50043-8.

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