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Relevant bibliographies by topics / Bioadhesive drug delivery systems

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Academic literature on the topic 'Bioadhesive drug delivery systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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Journal articles on the topic "Bioadhesive drug delivery systems"

1

Nielsen, Lise Sylvest, Lene Schubert, and Jens Hansen. "Bioadhesive drug delivery systems." European Journal of Pharmaceutical Sciences 6, no. 3 (July 1998): 231–39. http://dx.doi.org/10.1016/s0928-0987(97)10004-5.

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Duchêne, Dominique. "Bioadhesive drug delivery systems." Journal of Controlled Release 15, no. 1 (February 1991): 84. http://dx.doi.org/10.1016/0168-3659(91)90106-n.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (March 1, 2005): 293–310. http://dx.doi.org/10.1081/ddc-200052073.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (January 2005): 293–310. http://dx.doi.org/10.1081/ddc-52073.

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Gavrovic-Jankulovic, Marija, and Radivoje Prodanovic. "Drug Delivery: Plant Lectins as Bioadhesive Drug Delivery Systems." Journal of Biomaterials and Nanobiotechnology 02, no. 05 (2011): 614–21. http://dx.doi.org/10.4236/jbnb.2011.225073.

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Ahmad, Farhan, Mohd Alam, Zeenat Khan, Roop Khar, and Mushir Ali. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica 58, no. 4 (December 1, 2008): 407–19. http://dx.doi.org/10.2478/v10007-008-0023-2.

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Development andin vitroevaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infectionsAn acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along withLactobacillusspores to treat mixed vaginal infections. Theex vivoretention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of thein vitroantimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in anex vivoretention experiment.

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Gupta, Sabnam, Sudip Das, Abhay Singh, and Suman Ghosh. "A Brief Review on Bucco-adhesive Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 4-S (August 15, 2021): 231–35. http://dx.doi.org/10.22270/jddt.v11i4-s.4934.

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The buccal region within the mucosal cavity of the mouth provides an alternative route over an oral drug administration for systemic as well as local drug delivery. As the buccal mucosa has an abundant blood supply and is relatively permeable, it can be considered as most accessible and desired location for both local and systemic drug delivery. The buccal method for medication delivery greatly helps in avoiding issues in the gastrointestinal environment, such as increased first-pass metabolism and medication degradation. Bucco-adhesive systems offer varieties of advantages such as convenience in administration and termination of therapy in case of emergency, higher patient compliance, better bioavailability, rapid absorption, etc. This current review highlights the bucco-adhesive drug delivery system, its advantages and limitations, mechanisms and theories of mucoadhesion, different bucco-adhesive dosage forms, and bioadhesive polymers. It also highlights the current status on mucoadhesive drug delivery methods for the buccal cavity or bucco-adhesive systems. Keywords: Bioadhesion, mucoadhesion, bucco-adhesive drug delivery system, oral mucosa, first-pass metabolism, bioadhesive polymers.

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Prasad, G., K. Devika, P. Varshith, B. Shravani, E. Pavithra, and Ch Swathi. "Design and Optimizations of Aceclofenac Bioadhesive Extended Release Microspheres." Pharmaceutics and Pharmacology Research 4, no. 4 (December 3, 2021): 01–15. http://dx.doi.org/10.31579/2693-7247/055.

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The oral route for drug delivery is the most popular, desirable, and most preferred method for administrating therapeutically agents for systemic effects because it is a natural, convenient, and cost effective to manufacturing process. Oral route is the most commonly used route for drug administration. Although different route of administration are used for the delivery of drugs, oral route remain the preferred mode. Even for sustained release systems the oral route of administration has been investigated the most because of flexibility in designing dosage forms. Present controlled release drug delivery systems are for a maximum of 12 hours clinical effectiveness. Such systems are primarily used for the drugs with short elimination half life.

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Roychowdhury, Santanu, Rajesh Gupta, and Sourav Saha. "A Review on Buccal Mucoadhesive Drug Delivery Systems." Indo Global Journal of Pharmaceutical Sciences 01, no. 03 (2011): 223–33. http://dx.doi.org/10.35652/igjps.2011.22.

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Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. In this review article the advantages and limitations related to the buccal drug delivery has also been discussed. In buccal drug delivery systems mucoadhesion is the key element so various mucoadhesive polymers have been utilized in different dosages form. Various bioadhesive dosages form such as Chewing gum, tablets, Patches, Hydrogel, Thiolated tablets are discussed in this review article. Lastly the absorption/permeation study and different dissolution testing methods for bioadhesive dosages forms have also been discussed. © 2011 IGJPS. All rights reserved.

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Syeda Sualyha Noor and Muhammad Akram Choohan. "Formulation and evaluation of buccal bioadhesive tablets using glimepiride as a model drug." Journal of Contemporary Pharmacy 4, no. 2 (January 31, 2021): 34–38. http://dx.doi.org/10.56770/jcp2020422.

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Objectives: The present investigation is concerned with formulation and evaluation of bioadhesive buccal tabletscontaining antidiabetic drug, Glimepiride to circumvent the first pass effect and to improve its bioavailability because bioadhesion has shown renewed interest for prolonging the residence time of bioadhesive dosage forms through various mucosal routes in drug delivery applications. Bioadhesive-based topical and local systems have shown enhanced bioavailability. Bioadhesive drug delivery gives rapid absorption and good bioavailability due to itsconsiderable surface area and high blood flow. Drug delivery across the mucosa bypasses the first-pass hepaticmetabolism and avoiding the degradation of gastrointestinal enzymes and with reduction in dosing frequency and dose related side effects. Methods: The tablets were prepared by direct compression method. Six formulations weredeveloped with varying concentrations of polymers like sodium alginate, PVP and magnesium stearate. The tabletswere tested for weight variation, hardness, surface pH, drug content uniformity, percentage swelling index,bioadhesive strength, ex-vivo residence time in-vitro drug dissolution study, in-vitro drug release kinetic study, exvivo permeation study and Stability study. Results: FTIR studies showed no evidence on interactions between drug, polymers, and excipients. The surface pH, bioadhesive strength was found to be 6.22, 16g and, respectively. The formulation containing 4 mg of Glimepiride exhibited 6 h sustained drug release i.e. 93.98±0.8% with desiredtherapeutic concentration. The drug permeation from the formulation was slow and steady and 3.56 mg of Glimepiride could permeate through sheep buccal membrane with a flux of 0.27 mg hr-1 cm-2. The in-vitro release kinetics studies reveal that the formulation fits well with zero order kinetics. Conclusion: Hence, it was concluded that the formulation was suitable for all the evaluation parameters and can be permeated through human buccal mucosa.

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Dissertations / Theses on the topic "Bioadhesive drug delivery systems"

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Lawlor, Michelle S. "Rheological characterisation of bioadhesive drug delivery systems." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326370.

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Armstrong, Michelle. "Elucidating bioadhesive processes in nasal drug delivery systems." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23193.

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Mucoadhesive formulations have been used to increase the residence time and improve bioavailability of nasal dosage forms. The exact nature of the interplay between formulations and the mucus layer has not been defined, although theories have been proposed suggesting that certain characteristics are required for optimum mucoadhesivity. This thesis presents an investigation into the effects of the properties of excipients in nasal formulations on their mucoadhesive performance. The main factors that were investigated included molecular weight, concentration, crosslinking density, charge, and viscosity. It was established using rotational and oscillation rheology that the polymeric formulations with the highest molecular weight expressed the highest viscosity. Thixotropy, a vital property in mucoadhesion, was also assessed. The greatest thixotropy was found with polymers of increasing molecular weight whereas low molecular weight polymers exhibited little or no thixotropy. As expected, high molecular weight polymers produced strongly gelled networks; a requirement for mucoadhesion. Mucoadhesive interactions between polymers and mucin were analysed using standard rheology and microrheology. Greater synergy was found with high molecular weight, linear, ionic polymers; factors which allow for improved chain interactions. Texture analysis of the formulations confirmed that the adhesive forces increased for higher molecular weight, ionic polymers. In conclusion, it was found that a combination of a high molecular weight, increased viscosity, charge, and a moderate level of crosslinking are all favourable properties in a polymeric nasal spray. The formulation of a mucoadhesive dosage form with these characteristics may improve the retention time of the formulation within the nose, resulting in an increased opportunity for drug absorption and thus greater bioavailability.

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Caston, Antony James. "The potential of fimbriae for bioadhesive drug delivery systems." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315131.

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Soane, Robert J. "Bioadhesive polymers as intranasal drug delivery systems for peptide and protein drugs." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298078.

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Donnelly, R. F. "Bioadhesive drug delivery systems for photodynamic therapy of vulval intraepithelial neoplasia." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398149.

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Jackson, Sarah J. "The use of ion exchange resins as potential bioadhesive drug delivery systems." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311924.

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Birudaraj, Kondamraj. "Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/2733.

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The objective of this research was to investigate two important aspects of buccal drug delivery, transport and mucoadhesion. Buspirone was chosen as a model drug for the in vitro buccal transport studies, polyvinyl alcohol and sodium alginate polymer blends were prepared to investigate the mucoadhesive properties through a Lewis acid-base approach and finally, the effect of formulation factors on the force of mucoadhesion, surface energy parameters, release rate and flux was studied. In vitro permeation studies were conducted to investigate the buccal transport pathway of buspirone. Mathematical models were developed to quantify the process of permeation. Permeation enhancement of buspirone across the buccal mucosa was investigated using bile salts (sodium glycocholate and taurodeoxycholate), propylene glycol, propylene. Effect of formulation factors like drug, enhancer, and plasticizer was studied through statistically designed experiments. These experiments aided in characterizing the buccal delivery system. Mathematical models were developed for surface energy parameters, force of mucoadhesion, release rate, and flux. Research conducted in this dissertation focused on two important aspects of transbuccal delivery, drug transport and mucoadhesion by studying a model drug and polymer blends. The results obtained in these investigations can be utilized in the development of other bioadhesive delivery systems with respect to drug transport and mucoadhesion. Polymer blends of polyvinyl alcohol (PVA) and sodium alginate (Alg) were prepared to evaluate their mucoadhesive properties and investigate mucoadhesive mechanism by a Lewis acid-base approach. (Abstract shortened by UMI.)

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Goswani, Tarun. "Sublingual drug delivery : in vitro characterization of barrier properties and prediction of permeability." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/708.

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Xiang, Jun. "In vitro study of transbuccal drug delivery systems: Mucoadhesion of a novel bioadhesive and permeation of zalcitabine." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2744.

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A novel mucoadhesive poly[acrylic acid-co-poly(ethylene glycol) monomethylether monomethacrylate-co-2-(N, N-Dimethylamino)ethyl methacrylate], [poly(AA-PEGMM-DMEMA)], was designed and synthesized based on a hypothesis that interactions between the negative charged surface of the buccal mucosa and the positive charged constituent in bioadhesive would increase the mucoadhesion. Introducing the cationic monomer DMEMA to poly(AA-PEGMM) increased the Lewis acid-base interaction between the polymer and the buccal mucosa, which led to a thermodynamic favorable mucoadhesion process. The polymer containing 1% DMEMA yielded the highest force of mucoadhesion among the polymers studied. The ATR-FTIR study revealed that intrapolymer interactions between the carboxyl groups in AA and the amino groups in DMEMA and interactions between polymer and buccal surface played important roles in the mucoadhesion of poly(AA-PEGMM-DMEMA). The optimal mucoadhesion can be achieved by balancing these two interactions. The thermodynamic analysis revealed the contributions of Lifshitz-van der Waals interaction and Lewis acid-base interaction, such as the interactions between the hydroxyl groups and the ester groups, to the mucoadhesion. A general trend of mucoadhesion of the polymer can be predicted from the total free energy of adhesion (Δ G TOT ) at different hydration levels. A mathematical model was established to quantitatively describe the contributions of the three stages that involved in the process of adhesion to the force of mucoadhesion by the surface free energy, the total free energy of adhesion, and the hydration of the polymer. Zalcitabine (ddC) was selected as the model drug in the drug loading, in vitro release and permeation studies. Changing the pH of the swelling medium can greatly affect the swelling of the polymer. The drug loading increased 3.6 times when the pH of the loading solution was changed from 2.2 to 8. The process of the swelling and drug release followed Fickian diffusion mechanism. Compared to the permeation of ddC through the polymer, the permeation of ddC through the buccal mucosa was the rate-limiting barrier to the transbuccal delivery of ddC. ddC permeated through buccal mucosa by passive diffusion over the range of concentrations examined. The total permeability of ddC through the buccal mucosa was contributed by the permeation of ionized and unionized species of ddC. A bilayer diffusion model was established to describe the relations among the permeability of the epithelium, the connective tissue and the full-thickness buccal mucosa. The histological study revealed that the basal lamina within the epithelium of buccal mucosa acted as the major barrier to the permeation of ddC. The permeation of ddC through the buccal mucosa can be effectively enhanced by co-administrating a penetration enhancer sodium glycodeoxycholate (GDC). GDC enhanced the buccal permeability of ddC up to 32 times. A zero-order delivery of the currently approved dosage of ddC can be achieved by a poly(AA-PEGMM-DMEMA) transbuccal drug delivery device with GDC as the penetration enhancer. The transbuccal delivery is a potential route for the administration of ddC.

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Liu, Ping. "Preparation and evaluation of alginate-pectin-poly-/-lysine particulates for drug delivery and evaluation of melittin as a novel absorption enhancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0002/MQ42408.pdf.

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Books on the topic "Bioadhesive drug delivery systems"

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Vincent, Lenaerts, and Gurny Robert, eds. Bioadhesive drug delivery systems. Boca Raton, Fla: CRC Press, 1990.

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Khutoryanskiy, Vitaliy V. Mucoadhesive materials and drug delivery systems. Chichester, West Sussex: John Wiley & Sons, Inc., 2014.

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International, Joint Workshop of the Association for Pharmaceutical Technology (APV) and the Controlled Release Society (CRS) (1st 1989 Leiden Netherlands). Bioadhesion: Possibilities and future trends ; first International Joint Workshop of the Association for Pharmaceutical Technology (APV) and the Controlled Release Society (CRS), Leiden, 22-24 May, 1989. Stuttgart: Wissenschaftliche Verlagsgsellschaft, 1990.

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Coghlan, Andy. Drug delivery systems. Letchworth: Society of Chemical Industry, 1985.

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A, Hollinger Mannfred, ed. Drug delivery systems. 2nd ed. Boca Raton: CRC Press, 2004.

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Ranade, Vasant V. Drug delivery systems. 3rd ed. Boca Raton: CRC Press, 2011.

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Jain, Kewal K., ed. Drug Delivery Systems. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-210-6.

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Jain, Kewal K., ed. Drug Delivery Systems. New York, NY: Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4939-9798-5.

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Ranade, Vasant V. Drug delivery systems. Boca Raton, Fla: CRC Press, 1996.

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Popescu, Maria A. Drug delivery. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Book chapters on the topic "Bioadhesive drug delivery systems"

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Hoffman, A. S., G. H. Chen, S. Y. Kaang, Z. L. Ding, K. Randeri, and B. Kabra. "Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 62–66. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_12.

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Leung, Sau-Hung S., and Joseph R. Robinson. "Bioadhesive Drug Delivery." In ACS Symposium Series, 350–66. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0467.ch023.

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Larrañeta, Eneko, and Ryan F. Donnelly. "Bioadhesive Polymers for Drug Delivery." In Polymers for Biomedicine, 559–601. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118967904.ch18.

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Holowka, Eric P., and Sujata K. Bhatia. "Controlled-Release Systems." In Drug Delivery, 7–62. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1998-7_2.

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Hombach, Juliane, and Andreas Bernkop-Schnürch. "Mucoadhesive Drug Delivery Systems." In Drug Delivery, 251–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00477-3_9.

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Holowka, Eric P., and Sujata K. Bhatia. "Smart Drug Delivery Systems." In Drug Delivery, 265–316. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1998-7_7.

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Lowman, A. M., Nicholas A. Peppas, M. Morishita, and T. Nagai. "Novel Bioadhesive Complexation Networks for Oral Protein Drug Delivery." In ACS Symposium Series, 156–64. Washington, DC: American Chemical Society, 1998. http://dx.doi.org/10.1021/bk-1998-0709.ch012.

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Shakesheff, Kevin M. "Drug Delivery Systems." In Handbook of Biodegradable Polymers, 363–78. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527635818.ch15.

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Ito, Yoshihiro. "Drug Delivery Systems." In Photochemistry for Biomedical Applications, 231–75. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0152-0_9.

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Bondi, Joseph V., and D. G. Pope. "Drug Delivery Systems." In Drug Discovery and Development, 291–325. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4828-6_11.

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Conference papers on the topic "Bioadhesive drug delivery systems"

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Fischer, Kathleen, Sarah Tao, Hugh Daniels, Esther Li, and Tejal Desai. "Silicon nanowires for bioadhesive drug delivery." In 2008 IEEE International Electron Devices Meeting (IEDM). IEEE, 2008. http://dx.doi.org/10.1109/iedm.2008.4796686.

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George, Ashline, and Jerin Cyriac. "Nano particle based drug delivery systems." In 2017 Third International Conference on Advances in Electrical, Electronics, Information, Communication and Bio-Informatics (AEEICB). IEEE, 2017. http://dx.doi.org/10.1109/aeeicb.2017.7972386.

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Chen, Michael. "Nanotechnologies for Advanced Drug Delivery Systems." In The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icbb19.02.

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Bellazzi, R. "Predictive fuzzy controllers for drug delivery." In Second International Conference on `Intelligent Systems Engineering'. IEE, 1994. http://dx.doi.org/10.1049/cp:19940635.

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Breland, Matthew, Badal Patel, and Hassan Bajwa. "Engineered nanoparticles for targeted drug delivery." In 2012 IEEE Long Island Systems, Applications and Technology Conference (LISAT). IEEE, 2012. http://dx.doi.org/10.1109/lisat.2012.6223198.

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Po-Ying Li, Jason Shih, Ronalee Lo, Bonnie Adams, Rajat Agrawa, Saloomeh Saati, Mark S. Humayun, Yu-Chong Tai, and Ellis Meng. "An electrochemical intraocular drug delivery device." In 2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2007. http://dx.doi.org/10.1109/memsys.2007.4433047.

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Langer, Robert S. "Microtechnologies and Nanotechnologies in Drug Delivery." In 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2021. http://dx.doi.org/10.1109/mems51782.2021.9375270.

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Terracciano, M., L. De Stefano, H. A. Santos, A. Lamberti, N. M. Martucci, M. A. Shahbazi, A. Correia, I. Ruggiero, I. Rendina, and I. Rea. "Diatomite nanoparticles as potential drug delivery systems." In 2015 International Conference on BioPhotonics (BioPhotonics). IEEE, 2015. http://dx.doi.org/10.1109/biophotonics.2015.7304032.

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Choudhary, S., J. M. Reck, and S. R. Bhatia. "Hydrophobically modified alginate for drug delivery systems." In 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967735.

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Meng, Ellis. "Polymer BioMEMS for implantable drug delivery systems." In 2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2009. http://dx.doi.org/10.1109/nems.2009.5068786.

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Reports on the topic "Bioadhesive drug delivery systems"

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada439254.

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Popova, Teodora, Borislav Tzankov, Christina Voycheva, Krassimira Yoncheva, and Nikolai Lambov. Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2019. http://dx.doi.org/10.7546/crabs.2019.12.08.

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada469974.

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Zarabi, Bahar. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, December 2007. http://dx.doi.org/10.21236/ada480781.

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