Journal articles: 'Bioadhesive drug delivery systems'

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Nielsen, Lise Sylvest, Lene Schubert, and Jens Hansen. "Bioadhesive drug delivery systems." European Journal of Pharmaceutical Sciences 6, no. 3 (July 1998): 231–39. http://dx.doi.org/10.1016/s0928-0987(97)10004-5.

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Duchêne, Dominique. "Bioadhesive drug delivery systems." Journal of Controlled Release 15, no. 1 (February 1991): 84. http://dx.doi.org/10.1016/0168-3659(91)90106-n.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (March 1, 2005): 293–310. http://dx.doi.org/10.1081/ddc-200052073.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (January 2005): 293–310. http://dx.doi.org/10.1081/ddc-52073.

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Gavrovic-Jankulovic, Marija, and Radivoje Prodanovic. "Drug Delivery: Plant Lectins as Bioadhesive Drug Delivery Systems." Journal of Biomaterials and Nanobiotechnology 02, no. 05 (2011): 614–21. http://dx.doi.org/10.4236/jbnb.2011.225073.

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Ahmad, Farhan, Mohd Alam, Zeenat Khan, Roop Khar, and Mushir Ali. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica 58, no. 4 (December 1, 2008): 407–19. http://dx.doi.org/10.2478/v10007-008-0023-2.

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Development andin vitroevaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infectionsAn acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along withLactobacillusspores to treat mixed vaginal infections. Theex vivoretention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of thein vitroantimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in anex vivoretention experiment.

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Gupta, Sabnam, Sudip Das, Abhay Singh, and Suman Ghosh. "A Brief Review on Bucco-adhesive Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 4-S (August 15, 2021): 231–35. http://dx.doi.org/10.22270/jddt.v11i4-s.4934.

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The buccal region within the mucosal cavity of the mouth provides an alternative route over an oral drug administration for systemic as well as local drug delivery. As the buccal mucosa has an abundant blood supply and is relatively permeable, it can be considered as most accessible and desired location for both local and systemic drug delivery. The buccal method for medication delivery greatly helps in avoiding issues in the gastrointestinal environment, such as increased first-pass metabolism and medication degradation. Bucco-adhesive systems offer varieties of advantages such as convenience in administration and termination of therapy in case of emergency, higher patient compliance, better bioavailability, rapid absorption, etc. This current review highlights the bucco-adhesive drug delivery system, its advantages and limitations, mechanisms and theories of mucoadhesion, different bucco-adhesive dosage forms, and bioadhesive polymers. It also highlights the current status on mucoadhesive drug delivery methods for the buccal cavity or bucco-adhesive systems. Keywords: Bioadhesion, mucoadhesion, bucco-adhesive drug delivery system, oral mucosa, first-pass metabolism, bioadhesive polymers.

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Prasad, G., K. Devika, P. Varshith, B. Shravani, E. Pavithra, and Ch Swathi. "Design and Optimizations of Aceclofenac Bioadhesive Extended Release Microspheres." Pharmaceutics and Pharmacology Research 4, no. 4 (December 3, 2021): 01–15. http://dx.doi.org/10.31579/2693-7247/055.

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The oral route for drug delivery is the most popular, desirable, and most preferred method for administrating therapeutically agents for systemic effects because it is a natural, convenient, and cost effective to manufacturing process. Oral route is the most commonly used route for drug administration. Although different route of administration are used for the delivery of drugs, oral route remain the preferred mode. Even for sustained release systems the oral route of administration has been investigated the most because of flexibility in designing dosage forms. Present controlled release drug delivery systems are for a maximum of 12 hours clinical effectiveness. Such systems are primarily used for the drugs with short elimination half life.

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Roychowdhury, Santanu, Rajesh Gupta, and Sourav Saha. "A Review on Buccal Mucoadhesive Drug Delivery Systems." Indo Global Journal of Pharmaceutical Sciences 01, no. 03 (2011): 223–33. http://dx.doi.org/10.35652/igjps.2011.22.

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Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. In this review article the advantages and limitations related to the buccal drug delivery has also been discussed. In buccal drug delivery systems mucoadhesion is the key element so various mucoadhesive polymers have been utilized in different dosages form. Various bioadhesive dosages form such as Chewing gum, tablets, Patches, Hydrogel, Thiolated tablets are discussed in this review article. Lastly the absorption/permeation study and different dissolution testing methods for bioadhesive dosages forms have also been discussed. © 2011 IGJPS. All rights reserved.

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Syeda Sualyha Noor and Muhammad Akram Choohan. "Formulation and evaluation of buccal bioadhesive tablets using glimepiride as a model drug." Journal of Contemporary Pharmacy 4, no. 2 (January 31, 2021): 34–38. http://dx.doi.org/10.56770/jcp2020422.

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Objectives: The present investigation is concerned with formulation and evaluation of bioadhesive buccal tabletscontaining antidiabetic drug, Glimepiride to circumvent the first pass effect and to improve its bioavailability because bioadhesion has shown renewed interest for prolonging the residence time of bioadhesive dosage forms through various mucosal routes in drug delivery applications. Bioadhesive-based topical and local systems have shown enhanced bioavailability. Bioadhesive drug delivery gives rapid absorption and good bioavailability due to itsconsiderable surface area and high blood flow. Drug delivery across the mucosa bypasses the first-pass hepaticmetabolism and avoiding the degradation of gastrointestinal enzymes and with reduction in dosing frequency and dose related side effects. Methods: The tablets were prepared by direct compression method. Six formulations weredeveloped with varying concentrations of polymers like sodium alginate, PVP and magnesium stearate. The tabletswere tested for weight variation, hardness, surface pH, drug content uniformity, percentage swelling index,bioadhesive strength, ex-vivo residence time in-vitro drug dissolution study, in-vitro drug release kinetic study, exvivo permeation study and Stability study. Results: FTIR studies showed no evidence on interactions between drug, polymers, and excipients. The surface pH, bioadhesive strength was found to be 6.22, 16g and, respectively. The formulation containing 4 mg of Glimepiride exhibited 6 h sustained drug release i.e. 93.98±0.8% with desiredtherapeutic concentration. The drug permeation from the formulation was slow and steady and 3.56 mg of Glimepiride could permeate through sheep buccal membrane with a flux of 0.27 mg hr-1 cm-2. The in-vitro release kinetics studies reveal that the formulation fits well with zero order kinetics. Conclusion: Hence, it was concluded that the formulation was suitable for all the evaluation parameters and can be permeated through human buccal mucosa.

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Brahmbhatt, Devarshi. "Bioadhesive drug delivery systems: Overview and recent advances." International Journal of Chemical and Life Sciences 6, no. 3 (June 16, 2017): 2016. http://dx.doi.org/10.21746/ijcls.2017.3.1.

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Bio adhesive systems have gained growing interest due to its ability to localize the drug delivery along with sustained release. This leads to reduction of side-effects due to non-specific targeting. This review provides an overview of the understanding of bioadhesive drug delivery system along with the recent advances in their formulation development.

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Raj, Hans, Shagun Sharma, Ankita Sharma, Kapil Kumar Verma, and Amit Chaudhary. "A Novel Drug Delivery System: Review on Microspheres." Journal of Drug Delivery and Therapeutics 11, no. 2-S (April 15, 2021): 156–61. http://dx.doi.org/10.22270/jddt.v11i2-s.4792.

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Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the right timeframe, resulting in little toxicity and minimal side effects. There are different approaches to supplying the medicinal drug to the target site in a continuous managed manner. One such strategy is the use of microspheres as drug carriers. In this article, the value of the microsphere is seen as a novel drug delivery carrier to achieve site-specific drug delivery was discussed. Keywords: microspheres, method of preparations, polymer, bioadhesion, types of microspheres

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Walia, Smily, J. S. Dua, and D. N. Prasad. "A Novel Drug Delivery of Microspheres." Journal of Drug Delivery and Therapeutics 11, no. 6 (November 15, 2021): 257–64. http://dx.doi.org/10.22270/jddt.v11i6.5059.

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Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to a specific region. Microspheres are free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging from 1 to 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption and desorption by regeneration .The study demonstrates how microsphere parameters are planned and measured. Bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, and radioactive microspheres are only a few examples of complicated microspheres. Cosmetics, oral medication administration, target drug delivery, ocular drug delivery, gene delivery, and other industries covered in the paper could all benefit from microspheres. To ensure best therapeutic effectiveness, the agent must be delivered to target tissue at an optimal amount during the appropriate timeframe, with low toxicity and adverse effects. There are several methods for delivering the therapeutic substance to the target site in a controlled manner. The use of microspheres as medication carriers is one such technique. The value of microspheres as a novel drug delivery carrier to accomplish site-specific drug delivery was discussed in this article. Keywords: Microspheres, method of preparations, polymer bioadhesion, types of microspheres.

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Hussain, N. "Bioadhesive Drug Delivery Systems: Fundamentals, novel approaches and development." International Journal of Pharmaceutics 205, no. 1-2 (September 2000): 201–2. http://dx.doi.org/10.1016/s0378-5173(00)00502-0.

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Lehr, Claus-Michael, and Jochen Haas. "Developments in the area of bioadhesive drug delivery systems." Expert Opinion on Biological Therapy 2, no. 3 (March 2002): 287–98. http://dx.doi.org/10.1517/14712598.2.3.287.

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Pattan, S. R., N. P. Wani, M. U. Shelar, S. A. Nirmal, P. D. Chaudhari, and R. S. Gude. "SCOPE AND SIGNIFICANCE OF FLOATING DRUG DELIVERY SYSTEM." INDIAN DRUGS 49, no. 10 (October 28, 2012): 5–12. http://dx.doi.org/10.53879/id.49.10.p0005.

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In recent years there have been several scientific and technological advancements in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities,such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems,polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

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Ankit Kumar and Sanjeev Kumar. "Intra Vaginal Drug Delivery System (Novel Drug Delivery System)." International Journal for Research in Applied Sciences and Biotechnology 7, no. 6 (December 26, 2020): 234–41. http://dx.doi.org/10.31033/ijrasb.7.6.33.

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In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections, cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as locally active drugs (metronidazole Zidovudine, Lamivudine) can be effectively delivered for an extended period of time by the help of intra-vaginal controlled release system. Continuous infusion of drugs through vaginal mucosa results in the reduced possibilities of Hepatic- gastrointestinal first-pass metabolism, gastric impatience of drugs and vacillation of dosing interval. Current study focus on the, use of various polymers which are used in hydrogels, these polymers provide bioadhesive property to the vaginal formulations, so that the vaginal formulation remains on vaginal tissues for 3- 4 days. Currently available vaginal dosage forms have several limitations, such as leakage and messiness necessitating the need to develop novel drug delivery systems.

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Dubashynskaya, Natallia V., and Yury A. Skorik. "Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives." International Journal of Molecular Sciences 23, no. 21 (October 26, 2022): 12980. http://dx.doi.org/10.3390/ijms232112980.

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Mucoadhesive polymer patches are a promising alternative for prolonged and controlled delivery of topical corticosteroids (CS) to improve their biopharmaceutical properties (mainly increasing local bioavailability and reducing systemic toxicity). The main biopharmaceutical advantages of patches compared to traditional oral dosage forms are their excellent bioadhesive properties and their increased drug residence time, modified and unidirectional drug release, improved local bioavailability and safety profile, additional pain receptor protection, and patient friendliness. This review describes the main approaches that can be used for the pharmaceutical R&D of oromucosal patches with improved physicochemical, mechanical, and pharmacological properties. The review mainly focuses on ways to increase the bioadhesion of oromucosal patches and to modify drug release, as well as ways to improve local bioavailability and safety by developing unidirectional -release poly-layer patches. Various techniques for obtaining patches and their influence on the structure and properties of the resulting dosage forms are also presented.

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Ibrahim, Mohamed Moustafa, Doaa Nabih Maria, XiangDi Wang, Raven N. Simpson, T. J. Hollingsworth, and Monica M. Jablonski. "Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology." Pharmaceutics 12, no. 8 (July 26, 2020): 704. http://dx.doi.org/10.3390/pharmaceutics12080704.

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Corneal penetration is a key rate limiting step in the bioavailability of topical ophthalmic formulations that incorporate poorly permeable drugs. Recent advances have greatly aided the ocular delivery of such drugs using colloidal drug delivery systems. Ribavirin, a poorly permeable BCS class-III drug, was incorporated in bioadhesive multiple W/O/W microemulsion (ME) to improve its corneal permeability. The drug-loaded ME was evaluated regarding its physical stability, droplet size, PDI, zeta potential, ultrastructure, viscosity, bioadhesion, in vitro release, transcorneal permeability, cytotoxicity, safety and ocular tolerance. Our ME possessed excellent physical stability, as it successfully passed several cycles of centrifugation and freeze–thaw tests. The formulation has a transparent appearance due to its tiny droplet size (10 nm). TEM confirmed ME droplet size and revealed its multilayered structure. In spite of the high aqueous solubility and the low permeability of ribavirin, this unique formulation was capable of sustaining its release for up to 24 h and improving its corneal permeability by 3-fold. The in vitro safety of our ME was proved by its high percentage cell viability, while its in vivo safety was confirmed by the absence of any sign of toxicity or irritation after either a single dose or 14 days of daily dosing. Our ME could serve as a vehicle for enhanced ocular delivery of drugs with different physicochemical properties, including those with low permeability.

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Tiwari, Sarika Sharma, Shailesh K. Gupta, Sumeet Dwivedi, and Raghvendra Dubey. "Formulation and evaluation of in situ herbal gel containing aqueous and methanolic extract of fruits of Quercus infectoria Oliv. for vaginal application." Journal of Drug Delivery and Therapeutics 8, no. 5 (September 14, 2018): 495–503. http://dx.doi.org/10.22270/jddt.v8i5.1913.

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Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of an antifungal drug to formulated In-situ gel. Quercus infectoria is medicinally important plant grown wildly in India and is useful in the treatment of fungal and microbial infection by tribal’s of India. The plant is used by tribal women to treat vaginal infection as mentioned in folk-lore. Therefore, the present plant as selected to formulate in-situ herbal gel using Quercus infectoria as active ingredients for the treatment of vaginal infection. Keywords: Herbal Gels, Quercus infectoria, bioadhesive, vaginal drug delivery

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Venkateswara Rao, Korlapati, and V. V. Venkatachalam. "Recent Advances in Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 3 (May 31, 2016): 3221–54. http://dx.doi.org/10.37285/ijpsn.2016.9.3.1.

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Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, muco-adhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive drug delivery systems. Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by a narrow absorption window. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. So, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and required benefits to patients. The purpose of writing the article was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In particular, bioadhesive, size-increasing and floating drug delivery systems are presented and their major advantages and shortcomings are critically discussed in this review. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients

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Singh, Sudarshan, and Hitesha Goswami. "Formulation of Oral Mucoadhesive Tablets of Pioglitazone using Natural Gum from Seeds of Pithecellobium Dulce." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (November 30, 2015): 3031–38. http://dx.doi.org/10.37285/ijpsn.2015.8.4.6.

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The plant derived gums and mucilage’s comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified to meet the specific need. The present study was undertaken to isolate mucilage from the seeds of Pithecellobium dulce (P. dulce). The mucilage isolated from P. dulce were used as a bioadhesive polymer in tablet formulation and evaluated for the parameters such as swelling, pH, and bioadhesive property like bioadhesive strength, and ex-vivo residence time. The oral mucoadhesive tablets were prepared using Pioglitazone as model drug and P. dulce seeds mucilage as mucoadhesive polymer. The prepared tablets were evaluated against existing mucoadhesive polymer such as Xanthan gum and Hydroxyl Propyl Methyl Cellulose K4M to explore its use as Pharmaceutical excipients. Swelling index of P. dulce was found to be 87.46 ± 0.11 % which was higher than Xanthan gum but lower than HPMC K4M having swelling index 73.28 ± 0.01 % and 98.88 ± 0.03 % respectively. The results showed that Bioadhesion strength of P. dulce was found to be 50.86 ± 0.03N which was higher than HPMC K4M but lower than Xanthan gum having Force of adhesion 32.81 ± 0.04N and 57.17 ± 0.01N respectively. The percentage cumulative drug release drug release of optimize batch F8 was found to be 101.71 %. So, it was concluded that the mucilage of P. dulce can be used as a pharmaceutical excipient in oral bioadhesive drug delivery systems.

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Margalit, Rimona, Malka Okon, Noga Yerushalmi, and Einat Avidor. "Bioadhesive liposomes as topical drug delivery systems: molecular and cellular studies." Journal of Controlled Release 19, no. 1-3 (March 1992): 275–87. http://dx.doi.org/10.1016/0168-3659(92)90083-4.

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Salem-Bekhit, Mounir M., Abdullah M. E. Youssof, Fars K. Alanazi, Fadilah Sfouq Aleanizy, Alsuwyeh Abdulaziz, Ehab I. Taha, and Amro Abd Al Fattah Amara. "Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems." Pharmaceutics 13, no. 12 (November 23, 2021): 1984. http://dx.doi.org/10.3390/pharmaceutics13121984.

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Bacterial ghosts (BGs) are empty cell envelopes of nonliving evacuated bacterial cells. They are free from their cytoplasmic contents; however, they sustain their cellular 3D morphology and antigenic structures, counting on bioadhesive properties. Lately, they have been tested as an advanced drug delivery system (DDS) for different materials like DNA, peptides, or drugs, either single components or combinations. Different studies have revealed that, BG DDS were paid the greatest attention in recent years. The current review explores the impact of BGs on the field of drug delivery and drug targeting. BGs have a varied area of applications, including vaccine and tumor therapy. Moreover, the use of BGs, their synthesis, their uniqueness as a delivery system and application principles in cancer are discussed. Furthermore, the safety issues of BGs and stability aspects of using ghost bacteria as delivery systems are discussed. Future perspective efforts that must be followed for this important system to continue to grow are important and promising.

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Silva, Silas Arandas Monteiro e., Rísia Lacerda, Jéssica Bernegossi, Marlus Chorilli, and Gislaine Ricci Leonardi. "Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application." Brazilian Journal of Pharmaceutical Sciences 52, no. 1 (March 2016): 211–20. http://dx.doi.org/10.1590/s1984-82502016000100023.

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ABSTRACT Liquid-Crystalline Systems represent active compounds delivery systems that may be able to overcome the physical barrier of the skin, especially represented by the stratum corneum. To obtain these systems, aqueous and oily components are used with surfactants. Of the different association structures in such systems, the liquid-crystalline offer numerous advantages to a topical product. This manuscript presents the development of liquid-crystalline systems consisting, in which the oil component is olive oil, its rheological characterizations, and the location of liquid crystals in its phase map. Cytotoxic effects were evaluated using J-774 mouse macrophages as the cellular model. A phase diagram to mix three components with different proportions was constructed. Two liquid crystalline areas were found with olive oil in different regions in the ternary diagram with two nonionic surfactants, called SLC1 (S1) and SLC2 (S2). These systems showed lamellar liquid crystals that remained stable during the entire analysis time. The systems were also characterized rheologically with pseudoplastic behavior without thixotropy. The texture and bioadhesion assays showed that formulations were similar statistically (p < 0.05), indicating that the increased amount of water in S2 did not interfere with the bioadhesive properties of the systems. In vitro cytotoxic assays showed that formulations did not present cytotoxicity. Olive oil-based systems may be a promising platform for skin delivery of drugs.

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Umar, Hassaan, Habibah A. Wahab, Amirah Mohd Gazzali, Hafsa Tahir, and Waqas Ahmad. "Cubosomes: Design, Development, and Tumor-Targeted Drug Delivery Applications." Polymers 14, no. 15 (July 31, 2022): 3118. http://dx.doi.org/10.3390/polym14153118.

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Because of the extraordinary advancements in biomedical nanotechnology over the last few decades, traditional drug delivery systems have been transformed into smart drug delivery systems that respond to stimuli. These well-defined nanoplatforms can boost therapeutic targeting efficacy while reducing the side effects/toxicities of payloads, which are crucial variables for enhancing patient compliance by responding to specific internal or external triggers. Cubosomes are lipid-based nano systems that are analogous to well-known vesicular systems, such as lipo- and niosomes. They could be used as part of a unique drug delivery system that includes hydro-, lipo-, and amphiphilic drug molecules. In this review, we critically analyze the relevant literature on cubosomesregarding theories of cubosomeself-assembly, composition, and manufacturing methods, with an emphasis on tumor-targeted drug delivery applications. Due to the bioadhesive and -compatible nature of cubosome dispersion, this review also focuses on a variety of drug delivery applications, including oral, ophthalmic and transdermal.

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Singh, Sudarshan, Sandip G. Maru, and Sunil Bothara B. "Formulation and Ex-vivo Evaluation of Glipizide Buccal Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (May 31, 2014): 2487–93. http://dx.doi.org/10.37285/ijpsn.2014.7.2.10.

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Bioadhesive materials are agents which adhere to the mucous membrane due to specific properties and release the drug at the site of action in controlled manner. Since the biodegradability of the synthetic polymer is at some instance hesitant. In this exploration, a bioadhesive polymer has been developed which was isolated from leaves of Aloe vera (L.) Burm. f. The mucilage isolated from A. vera were used as a bioadhesive polymer in tablet formulation and evaluated for the parameters such as swelling, pH, and bioadhesive property like bioadhesive strength, record of adherence and ex-vivo residence time. The buccal bioadhesive tablet was prepared using glipizide as model drug. The prepared tablet was evaluated against existing bioadhesive polymer such as guar gum and hydroxyl propyl cellulose. Swelling index and surface pH was found to be 13.12-18.06% and 6.5-6.9 respectively. The drug permeation through goat buccal mucosa was found to be 60.21 ± 0.06 % in the end of 7 h with a Jss of 0.24 mg h-1 cm-2. The stability studies were performed on optimized formulation as per ICH guideline, result showed that there was no significant change in physical characteristic, adhesive strength and in vitro release. It was observed that as the concentration of mucilage increases swelling index also increases. Results of pH showed that mucilage is slightly near to neutral in nature. Formulations were evaluated for preformulation parameters, in vitro drug release profile and release kinetics. The formulations were found to have good preformulation characteristics. FTIR spectroscopy showed no significant chemical interaction within drug and excipients. The release mechanism of glipizide from buccal tablets indicated anomalous (non-fickian) transport mechanism and followed zero order kinetics. It was concluded that the mucilage of A. vera can be used as a pharmaceutical excipient in buccal bioadhesive drug delivery systems.

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Kumari, Reena, Nishant Verma, Nidhi Chaudhary, and Umesh Kumar. "Gastro retentive Ethyl Cellulose Floating Microspheres containing ATENOLOL." International Journal of Advance Research and Innovation 3, no. 2 (2015): 209–19. http://dx.doi.org/10.51976/ijari.321537.

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Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Incorporation of the drug in a controlled release gastro -retentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current recently developments of Stomach Specific FDDS are discussed that helps to overcome physiological adversities like short gastric residence times and unpredictable gastric emptying times

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Kumar, Abhishek, and Meenakshi Bharkatiya. "A Review on Updates to Increase the Residence Time of Drug in the Stomach for Gastro Retentive Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 11, no. 02 (2021): 130–42. http://dx.doi.org/10.35652/igjps.2021.112008.

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Orally-administered controlled-release drug delivery systems are associated with the shortcomings of relatively short residence times in the human stomach as well as highly variable gastrointestinal (GI) transit times. Thus, considerable intra-individual and inter-individual differences in the bioavailability of drugs are observable. There are numerous drug substances which may benefit from prolonged and controlled GI passage times. As a solution to the problem, gastroretentive drug delivery systems (GRDDS), which feature an enhanced gastric residence time (GRT), were developed. Several approaches are currently used including Floating Drug Delivery System (FDDS), swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. The drugs having absorption window in the upper part of Gastro Intestinal Tract (GIT) have enhanced bioavailability when formulated through these techniques. The recent technological development for enhancing GRT including the physiological and formulation variables affecting gastric retention, patented delivery systems, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Despite the extensive research performed in the field of GRDDS, the development, the production, and the evaluation of floating devices are still challenging. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

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Gordeeva, D. S., A. V. Sitenkova (Bukhovets), and R. I. Moustafine. "Interpolyelectrolyte Complexes Based on Eudragit® Copolymers as Carriers for Bioadhesive Gastroretentive Metronidazole Delivery System." Drug development & registration 9, no. 2 (May 30, 2020): 72–76. http://dx.doi.org/10.33380/2305-2066-2020-9-2-72-76.

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Introduction. There are a number of drugs, the absorption zone of which is the upper region of the gastrointestinal tract (GIT) – the stomach and duodenum. To increase bioavailability, gastroretentive (intragastric) systems for the controlled drug delivery are being developed. To date, there are various approaches to ensure intragastric drug delivery. One of the most promising approaches is the use of excipients with bioadhesive properties, both individually and in combination with other types of gastroretentive systems.Aim. Development and research of new carriers for gastroretentive bioadhesive drug delivery systems based on interpolyelectrolyte complexes (IPEC) with the participation of chemically complementary poly(meth)acrylates of the Eudragit®.Materials and methods. The study of swelling ability was carried out in a medium of 0.1 M hydrochloric acid solution (pH 1.2) at a temperature of 37 ± 0.5 °C for 6 hours. The study of the release of metronidazole (MZ) from matrices based on the corresponding IPEC was performed on a DFZ II instrument (ERWEKA, Germany) according to the Flow Trough Cell method in 0.1 M HCl medium, pH 1.2, flow rate 4 ml/min in a closed cycle within 6 hours. The amount of released MZ was estimated by UV spectrophotometry on a Lambda 25 instrument (PerkinElmer, USA) at a wavelength of 274 nm. IPEC adhesion was studied using a TA.XTplus texture analyzer (Stable Micro Systems, UK).Results and discussion. Matrices based on IPEC 1 were disintegrated after being in a medium with a pH of 1.2 for 4 hours, matrices based on IPEC 4 were dissolved in an acidic medium for 3 hours. At the same time, matrices based on IPEC 2 and IPEC 3 retain their shape throughout the experiment and are characterized by rather high values of the degree of swelling. IPEC samples are characterized by higher adhesion performance compared to individual copolymers. The release of metronidazole from matrices based on IPEC 1 occurs in accordance with Fick's law of diffusion; from the matrix based on IPEC 4, MZ is released according to the anomalous transport mechanism.Conclusion. IPEC 3 is promising for use as carrier for gastroretentive bioadhesive systems of controlled delivery of metronidazole.

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Sip, Szymon, Magdalena Paczkowska-Walendowska, Natalia Rosiak, Andrzej Miklaszewski, Katarzyna Grabańska-Martyńska, Karolina Samarzewska, and Judyta Cielecka-Piontek. "Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems." Pharmaceuticals 14, no. 8 (July 23, 2021): 712. http://dx.doi.org/10.3390/ph14080712.

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Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with carvedilol (beta-blocker) to develop a formulation with a modified carvedilol release profile. As part of the research, six physical mixtures of chitosan with carvedilol were obtained and identified by spectral (PXRD, FT-IR, and Raman), thermal (DSC), and microscopic (SEM) methods. The next stage of the research estimated the profile changes and the dissolution rate for carvedilol in the obtained drug delivery systems; the reference sample was pure carvedilol. The studies were conducted at pH = 1.2 and 6.8, simulating the gastrointestinal tract conditions. Quantitative changes of carvedilol were determined using the developed isocratic UHPLC-DAD method. Established apparent permeability coefficients proved the changes in carvedilol’s permeability after introducing a drug delivery system through membranes simulating the gastrointestinal tract and skin walls. A bioadhesive potential of carvedilol–chitosan systems was confirmed using the in vitro model. The conducted research and the obtained results indicate a significant potential of using chitosan as an excipient in modern oral or epidermal drug delivery systems of carvedilol.

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de Oliveira, Rafaela Santos, Nadine Lysyk Funk, Juliana dos Santos, Thayse Viana de Oliveira, Edilene Gadelha de Oliveira, Cesar Liberato Petzhold, Tania Maria Haas Costa, Edilson Valmir Benvenutti, Monique Deon, and Ruy Carlos Ruver Beck. "Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process." Pharmaceutics 15, no. 1 (December 21, 2022): 20. http://dx.doi.org/10.3390/pharmaceutics15010020.

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The alliance between 3D printing and nanomaterials brings versatile properties to pharmaceuticals, but few studies have explored this approach in the development of skin delivery formulations. In this study, clobetasol propionate (CP) was loaded (about 25% w/w) in mesoporous silica nanomaterial (MSN) to formulate novel bioadhesive and hydrophilic skin delivery films composed of pectin (5% w/v) and carboxymethylcellulose (5% w/v) by 3D printing. As a hydrophobic model drug, CP was encapsulated in MSN at a 3:1 (w/w) ratio, resulting in a decrease of CP crystallinity and an increase of its dissolution efficiency after 72 h (65.70 ± 6.52%) as compared to CP dispersion (40.79 ± 4.75%), explained by its partial change to an amorphous form. The CP-loaded MSN was incorporated in an innovative hydrophilic 3D-printable ink composed of carboxymethylcellulose and pectin (1:1, w/w), which showed high tensile strength (3.613 ± 0.38 N, a homogenous drug dose (0.48 ± 0.032 mg/g per film) and complete CP release after 10 h. Moreover, the presence of pectin in the ink increased the skin adhesion of the films (work of adhesion of 782 ± 105 mN·mm). Therefore, the alliance between MSN and the novel printable ink composed of carboxymethylcellulose and pectin represents a new platform for the production of 3D-printed bioadhesive films, opening a new era in the development of skin delivery systems.

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Sontakke, Rupali, Rohit Singhal, Neetesh K. Jain, and Shantanu Sontakke. "Formulation and Evaluation of Polyherbal Gel containing Ethanolic Extract used as Local Anesthetics in Oral Cavity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (June 25, 2022): 85–88. http://dx.doi.org/10.25258/ijddt.12.1.16.

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Conventional dosage forms frequently produce leakages and drip. There is a need for the development of innovative formulation technology that fulfills certain criteria such as desirable product dispersion throughout the system, retention for intended intervals, and adequate release of drug. These features can be achieved using bioadhesives based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of drug to formulated In-situ polyherbal gel. Piper betel L. (Pan, leaves) fam. Piperaceae; Spilanthesacmella Murr. (Akarkara, fruit), fam. Asteraceae; Foeniculum vulgare Mill. (Fennel, fruits) fam. (Umbelliferae); Eugenia caryophyllus (Spreng.) Bullock and S.G. Harrison (Clove, clove bud) fam. (Myrataceae) and Capsicum annum L. (Capsicum, fruits) fam. Solanaceae is medicinally important and is used as local anesthetics in oral cavity and these herbs were taken for formulation of polyherbal gel using Carbopol 934 and HPMC. The prepared formulation was evaluated, and the results were presented. The results indicate that the PHG-3 have satisfactory results when compared with other formulated PHG.

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Aminu, Nafiu, and Seok Ming Toh. "APPLICABILITY OF NANOPARTICLES-HYDROGEL COMPOSITE IN TREATING PERIODONTAL DISEASES AND BEYOND." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (February 1, 2017): 65. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15709.

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Nanoparticles-Hydrogel Composite (nanogels) have yielded a surge in the design and development of novel drug delivery systems for the treatment of many ailments, including periodontal disease. The recent innovations in nanotechnological drug carrier systems seem promising, as it provides a means to improve the bioavailability of poorly soluble drugs, formulations of controlled and targeted drug delivery systems, drug release control base on the stimuli response, among others. Several polymeric nanoparticles-hydrogel co-formulations have been investigated during the last few years, mostly using synthetic & natural polymers. Some of the results and rewards achieved from these novel approaches are the use of bioadhesive polymers to achieve prolong drug release, the increment of intra-pocket drug penetration, the enhancement of mechanical properties using chemical crosslinkers and the possibility of loading multiple drugs in a unit delivery system. Furthermore, these nanotechnological advances have also shown that nanoparticles (NPs) possess great potential as drug carriers in periodontal disease treatment. The future utilization of these advantages will significantly improve dental care. The co-formulation of nanoparticles-hydrogel composite will yield additional benefits that are much greater than ordinary NPs or hydrogels in delivering of drug into the periodontal pockets. The aim of this review article is to summarises updates on the current and future nanotechnological approaches that are being investigated for the treatment of periodontitis, with particular attention to the nanogels, and to identify arenas which its exploration might lead to the development of an effective intra-pocket drug delivery systems for the treatment of periodontal diseases. The review also provided brief applications of nanogels in the management of other diseases.Keywords: Nanocomposite, Hydrogels, Nanoparticles, Nanogels, Periodontal intra-pocket drug delivery system, Nanotechnological approaches.

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Andrews, Gavin P., and David S. Jones. "Rheological Characterization of Bioadhesive Binary Polymeric Systems Designed as Platforms for Drug Delivery Implants." Biomacromolecules 7, no. 3 (March 2006): 899–906. http://dx.doi.org/10.1021/bm050620y.

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Lehr, Claus-Michael, Joke A. Bouwstra, Wouter Kok, Arthur B. J. Noach, Albertus G. de Boer, and Hans E. Junginger. "Development of bioadhesive drug delivery systems on the basis of specifically binding tomato lectin." Journal of Controlled Release 21, no. 1-3 (July 1992): 208. http://dx.doi.org/10.1016/0168-3659(92)90040-x.

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Baranowski, Przemysław, Bożena Karolewicz, Maciej Gajda, and Janusz Pluta. "Ophthalmic Drug Dosage Forms: Characterisation and Research Methods." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/861904.

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This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments,in situgels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommendedin vitroandin vivostudies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance.

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Karmakar, Anirban, Soumya Dev Maity, Shayeree Barua, and Raneet Das. "Microsphere: A Wander around Drug Delivery." Bionatura 7, no. 1 (February 15, 2022): 1–11. http://dx.doi.org/10.21931/rb/2022.07.01.13.

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Microspheres have free-flowing powder characteristics consisting of synthetic polymers and proteins with a particle size of 1-1000 μm. Microsphere improves bioavailability, stability and targets the drug to a selected site at a predetermined rate. Sorts of microspheres are bioadhesive, floating, radioactive, polymeric, and biodegradable microspheres. Therefore, the array of practices for the groundwork of microspheres offers a chance to regulate drug administration properties and develop the therapeutic efficacy of a given drug. The microsphere is spherical microparticles & is employed where predictable & consistent particle area is vital. The microspheres have the drug located centrally within the particle encased within the unique polymeric membrane. The present review highlights various sorts of microspheres, different methods of preparation, their applications, and various parameters to gauge their efficiency. Microspheres have received much attention not just for prolonged release but also for targeted medicine. A systematic review of one of the most promising drug delivery systems should be easier to read than the medical research articles, as they target a wider audience. The systematic reviews of the microparticles conclude that spherical microspheres & are accustomed to delivering the drug at the target site with specificity if modified and take care of the specified concentration at the location of interest without the untoward effects presented during a consistent therapy to help research and retrieval of health.

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Khadem, Elham, Mahshid Kharaziha, Hamid Reza Bakhsheshi-Rad, Oisik Das, and Filippo Berto. "Cutting-Edge Progress in Stimuli-Responsive Bioadhesives: From Synthesis to Clinical Applications." Polymers 14, no. 9 (April 22, 2022): 1709. http://dx.doi.org/10.3390/polym14091709.

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With the advent of “intelligent” materials, the design of smart bioadhesives responding to chemical, physical, or biological stimuli has been widely developed in biomedical applications to minimize the risk of wounds reopening, chronic pain, and inflammation. Intelligent bioadhesives are free-flowing liquid solutions passing through a phase shift in the physiological environment due to stimuli such as light, temperature, pH, and electric field. They possess great merits, such as ease to access and the ability to sustained release as well as the spatial transfer of a biomolecule with reduced side effects. Tissue engineering, wound healing, drug delivery, regenerative biomedicine, cancer therapy, and other fields have benefited from smart bioadhesives. Recently, many disciplinary attempts have been performed to promote the functionality of smart bioadhesives and discover innovative compositions. However, according to our knowledge, the development of multifunctional bioadhesives for various biomedical applications has not been adequately explored. This review aims to summarize the most recent cutting-edge strategies (years 2015–2021) developed for stimuli-sensitive bioadhesives responding to external stimuli. We first focus on five primary categories of stimuli-responsive bioadhesive systems (pH, thermal, light, electric field, and biomolecules), their properties, and limitations. Following the introduction of principal criteria for smart bioadhesives, their performances are discussed, and certain smart polymeric materials employed in their creation in 2015 are studied. Finally, advantages, disadvantages, and future directions regarding smart bioadhesives for biomedical applications are surveyed.

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Bernkop-Schnürch, Andreas, Claudia Humenberger, and Claudia Valenta. "Basic studies on bioadhesive delivery systems for peptide and protein drugs." International Journal of Pharmaceutics 165, no. 2 (May 1998): 217–25. http://dx.doi.org/10.1016/s0378-5173(98)00017-9.

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Pandey, Chandra Prakash, ,. Archana, and Abadhesh Kumar Niranjan. "A Comprehensive Review on Bio-Adhesive Microspheres." Journal of Drug Delivery and Therapeutics 12, no. 4-S (August 25, 2022): 239–44. http://dx.doi.org/10.22270/jddt.v12i4-s.5536.

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A controlled medication delivery system has historically been used to produce certain rates of release or spatial concentrations of active compounds. Recent developments in drugs and polymer science delivery technology have improved innovative drug delivery systems made of bio-adhesive microspheres, advancing the use of "bio-adhesion" in drug delivery. This research evaluates the bio-adhesive MSs via transmucosal management routes, comprising the mucosal in the gastrointestinal system and other lumen, based on the advantages of adhesion arrangements and the usefulness status of MSs in mucous transport. A few new-style bio-adhesive MSs and specific studies on cell adhesive MSs are specifically mentioned. Additionally, this study aims to demonstrate the improvements made by cell-selective bio-adhesion systems known as bio-adhesive Microspheres and a few MSs with a novel bio-adhesive design are mentioned. Additionally, this evaluation aims to demonstrate the developments of site-specific medication release through stimuli-responsive MSs and bio-adhesive MSs as cell-selective bio-adhesion systems. Even if those MSs exhibit real strength, agendas need to include a few insightful ideas. In the future, processes should be closely scrutinized, and more attention should be paid to powerful bio-adhesives and "second-generation mucoadhesives." These new MSs' meaningful scientific curricula address contemporary concerns and call for further focused studies. Keywords: Transmucosal delivery; stimuli-responsiveness; bioavailability; bioadhesive microspheres.

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Abourehab, Mohammad A. S., Rahul R. Rajendran, Anshul Singh, Sheersha Pramanik, Prachi Shrivastav, Mohammad Javed Ansari, Ravi Manne, Larissa Souza Amaral, and A. Deepak. "Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art." International Journal of Molecular Sciences 23, no. 16 (August 12, 2022): 9035. http://dx.doi.org/10.3390/ijms23169035.

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Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

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Moloney, Cara, Phoebe McCrorie, Chiara Bastianchich, Bernard Ucakar, Cameron Alexander, Maria Marlow, Véronique Préat, and Ruman Rahman. "DDEL-03. ASSESSING THE DEPTH OF DRUG PENETRATION INTO BRAIN PARENCHYMA FROM LOCAL DRUG DELIVERY SYSTEMS IN AN ORTHOTOPIC HIGH GRADE GLIOMA ALLOGRAFT USING ORBITRAP-SECONDARY ION MASS SPECTROMETRY." Neuro-Oncology 24, Supplement_7 (November 1, 2022): vii94. http://dx.doi.org/10.1093/neuonc/noac209.349.

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Abstract Local intracranial drug delivery for high-grade glioma has been developed over the last two decades with chemotherapeutic agents administered immediately adjuvant to neurosurgery to overcome poor blood brain barrier permeability. In addition to this, the incorporation of nanoparticles (NPs) into local drug delivery systems (DDS) can result in increased penetration of chemotherapeutics through brain parenchyma, transporting the drug further from the administration site than by drug molecule diffusion alone.Here we adopted two model local DDS containing NPs to compare the depth of penetration through brain parenchyma. Approach one consisted of a thermosensitive in situ assembling polymer matrix loaded with polymer-doxorubicin conjugated NPs which can line the resection cavity walls, while approach two consisted of drug-loaded (etoposide and olaparib) poly(lactic acid)-poly(ethylene glycol) polymeric NPs held within a bioadhesive pectin hydrogel and delivered via a spray device.We assessed the efficacy of both DDS at preventing recurrence of high-grade glioma in an orthotopic rat 9L gliosarcoma model following surgical resection. In addition to monitoring long-term survival, the effect of each DDS was measured histologically by H&E and by caspase-1 (inflammatory response) and ki67 (cell proliferation) immunostaining staining. Depth of drug penetration was evaluated on post-sacrificial sections using Orbitrap-Secondary Ion Mass Spectroscopy (OrbiSIMS) and fluorescent microscopy. In vivo data suggests that the delivery mechanism of the NPs affects the efficacy of the DDS, whereby long-term survival was observed in rats treated with the sprayed olaparib/etoposide NP formulation, relative to rats where olaparib/etoposide was simply pipetted into the resection cavity. OrbiSIMS confirmed the presence of doxorubicin, olaparib and etoposide in brain tissue. Our work encourages consideration of mass spectrometry modalities to complement in vivo efficacy studies, as an analytical tool to assess brain distribution of systemically administered drugs, or localised brain penetration of drugs released biomaterial-based DDS.

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Lu, Zhilei, Weiyang Chen, Josias H. Hamman, Jian Ni, and Xiaoling Zhai. "Chitosan-Polycarbophil Interpolyelectrolyte Complex as an Excipient for Bioadhesive Matrix Systems to Control Macromolecular Drug Delivery." Pharmaceutical Development and Technology 13, no. 1 (January 2008): 37–47. http://dx.doi.org/10.1080/10837450701702636.

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Gupta, A., S. Garg, and R. K. Khar. "Interpolymer Complexation and its Effect on Bioadhesive Strength 6 Dissolution Characteristics of Buccal Drug Delivery Systems." Drug Development and Industrial Pharmacy 20, no. 3 (January 1994): 315–25. http://dx.doi.org/10.3109/03639049409050185.

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Moustafine, R. I., V. V. Budnikov, S. G. Abdullina, Sh F. Nasibullin, and R. A. Saleev. "Polycomplex Carrier for Buccal Mucoadhesion Delivery of Metronidazole." Drug development & registration 9, no. 2 (May 30, 2020): 83–90. http://dx.doi.org/10.33380/2305-2066-2020-9-2-83-90.

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Introduction. One of the well-known requirements for buccal drug delivery systems is the demonstration of mucoadhesive properties of the carrier, ensuring retention on the mucosa for a long time with the gradual release of the included drug. It should be noted that one of the advantages of buccal systems compared with oral ones is the absence of the «first pass effect» through the liver.Aim. To carry out a physicochemical and pharmaceutical research of the interpolyelectrolyte complex (IPEC), obtained on the basis of pharmaceutically acceptable polymers – Eudragit® EPO and Noveon® AA-1, in comparison with the physical mixture and individual polymers, as a mucoadhesive delivery system of metronidazole for the treatment of periodontal diseases.Materials and methods. Obtained on the basis of a pair of pharmaceutical polymers (Eudragit® EPO and Noveon® AA-1), two IPEC samples were characterized by elemental analysis, FTIR spectroscopy, and modulated temperature differential scanning calorimetry (mDSC) in comparison with individual polymers and their physical mixtures. The study of swelling ability, bioadhesion and release was carried out in a medium simulating artificial salivary fluid (pH 7.0) at a temperature of 37 ± 0.1 °C. Mucoadhesion of polymer samples and IPEC was studied using a TA.XTplus texture analyzer (Stable Micro Systems, UK). The release of metronidazole (MD) from matrices based on the developed IPEC was studied on a CE 7Smart USP 4 apparatus (Sotax, Switzerland) using the Flow Trough Cell method at a speed a flow of 20 ml/min in an open cycle within 5 hours. The amount of released MD was estimated by UV spectrophotometry on a Lambda 25 instrument (PerkinElmer, USA) at a wavelength of 319 nm.Results and discussion. As a result of studies on the physicochemical and pharmaceutical properties, there was selected the optimal composition of a polycomplex carrier (IPEC 2) based on Eudragit® EPO and Noveon® AA-1, which is characterized by the required bioadhesive properties and the ability of providing controlled release of drug from the tablet matrix (with weight ratio MD/IPEC-2 1:0.5) in conditions mimicking oral cavity environment, which provides the necessary mode of buccal delivery of metronidazole in accordance with Fick's law of diffusion.Conclusion. IPEC 2 is a perspective for use as carrier for buccal controlled delivery of metronidazole.

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Singh, Sudarshan, Ayaz Ahmad, and Sunil Bothara B. "Formulation of Oral Mucoadhesive Tablets using Mucilage Isolated from Buchanania lanzan spreng Seeds." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (May 31, 2014): 2494–503. http://dx.doi.org/10.37285/ijpsn.2014.7.2.11.

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The present study was taken to formulate and evaluate mucilage obtained from Buchanania lanzan spreng seeds (BL) belonging to family anacardiacea for oral mucoadhesive drug delivery system containing losartan potassium. Physiochemical characteristics of mucilage, such as swelling index, microbial count, viscosity, hydration capacity, flow property, and pH were studied. The mucilage was evaluated for its mucoadhesive properties in compressed tablet, containing losartan potassium. Granules were prepared by wet granulation process using polyvinylpyrrolidone as binding agent. Mucilage was used in four different concentrations i.e., 21, 42 and 55% w/w. The tablet were prepared and evaluated for its physical property. Further, in vitro dissolution and swelling index was determined. The property of bioadhesive strength of isolated mucilage was compared with Guar gum and HPMC E5LV, which was used as standard mucoadhesive agent concentration. Bioadhesive strength of the tablet was measured on the modified physical balance. Result revealed that tablets had good physiochemical properties, and drug release was retarded as concentration of mucilage was increased. The force of adhesion was obtained 0.1238N, 0.2822N, 0.5175N, 0.8679N and 0.3983N respectively for F1, F2, F3, F4 and F5. Formulations were subjected for study the effect of agitation at different rpm. Formulation showed relative effect on release of drug from formulation. All the formulations were subjected to stability studies for three months, all formulations showed stability with respect to release pattern. In conclusions, these results indicate that the seed mucilage of BL can be a suitable excipient for oral mucoadhesive drug delivery systems.

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Rath, Rishi, Siddharth Tevatia, Anukriti Rath, Ashish Behl, Vishal Modgil, and Nikhil Sharma. "Mucoadhesive systems in dentistry: A review." International Journal of Dental Research 4, no. 2 (June 21, 2016): 25. http://dx.doi.org/10.14419/ijdr.v4i2.6283.

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For any treatment plan to succeed, two factors are paramount correct selection and application of pharmacologic agents and patient compliance. But what happens when both these are followed judiciously, but the medicine itself does not stay long enough to finish its action? Then we need something that will make the medicine stick literally. That is when bioadhesives have their say. Long-term adhesion of drugs to the oral mucosa is usually prevented by the continuous salivary flow and the mechanical movements of the tongue. Therefore, formulations acting as vehicle for local drug delivery to the oral mucosa need to have excellent mucoadhesive properties. The present article reviews mucoadhesive systems with various formulations that can be used in dentistry to improve local drug delivery.

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Prokes, Libor, Eva Snejdrova, Tomas Soukup, Jana Malakova, Vladislav Frolov, Jan Loskot, Rudolf Andrys, and Tomas Kucera. "Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study." Molecules 27, no. 19 (October 1, 2022): 6487. http://dx.doi.org/10.3390/molecules27196487.

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Although progress is evident in the effective treatment of joint replacement-related infections, it still remains a serious issue in orthopedics. As an example, the local application of antibiotics-impregnated bone grafts supplies the high drug levels without systemic side effects. However, antibiotics in the powder or solution form could be a risk for local toxicity and do not allow sustained drug release. The present study evaluated the use of an antibiotic gel, a water-in-oil emulsion, and a PLGA microparticulate solid dispersion as depot delivery systems impregnating bone grafts for the treatment of joint replacement-related infections. The results of rheological and bioadhesive tests revealed the suitability of these formulations for the impregnation of bone grafts. Moreover, no negative effect on proliferation and viability of bone marrow mesenchymal stem cells was detected. An ex vivo dissolution test of vancomycin hydrochloride and gentamicin sulphate from the impregnated bone grafts showed a reduced burst and prolonged drug release. The PLGA-based formulation proved to be particularly promising, as one-day burst release drugs was only 15% followed with sustained antibiotics release with zero-order kinetics. The results of this study will be the basis for the development of a new product in the Tissue Section of the University Hospital for the treatment of bone defects and infections of joint replacements.

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Pandu Ranga K R, Prakash Rao B, and Kalavathy D J. "Design, development, in vitro evaluation and pharmcokinetic studies of bioadhesive buccal patches for pioglitazone and glimepiride." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (November 9, 2020): 6654–62. http://dx.doi.org/10.26452/ijrps.v11i4.3579.

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The buccal film know-how has arisen as an advanced substitute to the other conventional types of drug delivery systems. The buccal mucosa is a suitable route of administration. In this study, a bioadhesive buccal therapeutic system using Glimepiride and Pioglitazone to prolong the residence time at its point of administration. The FTIR studies showed no chemical incompatibility between drugs and excipients. The DSC of the product showed two separate peaks for Pioglitazone and Glimepiride, indicating no potential incompatibility. It was found that the breadth of all buccal films ranges from 0.28 to 0.30 mm. In all formulations, drug content was determined to be in the range of 1.97 to 2.02 mg for glimepiride and 14.95 to 15.01 mg for pioglitazone. Total percentage of cumulative of drug released from all formulations are from 64.12% to 87.0% for glimepiride and 70.0% to 92.2% for pioglitazone. The predicted values by the model agree with actual values. The drugs were released for 12 h, and it was found to be Cmax for pioglitazone was 467.5 ng/mL and for glimepiride was 65 ng/mL. Tmax was determined for pioglitazone was three h and for glimepiride was 2.8 h. The drugs are released for 12 h AUC of pioglitazone is 4031.25 h ng/mL, and AUC of glimepiride is 505 h ng/mL. Buccal patch for glimepiride and pioglitazone was prepared successfully.

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Journal articles on the topic 'Bioadhesive drug delivery systems'

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