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Relevant bibliographies by topics / Bioanalytical method development / Dissertations / Theses

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Dissertations / Theses on the topic 'Bioanalytical method development'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Malm, Mikaela. "Drug Analysis : Bioanalytical Method Development and Validation." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8547.

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This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. Developed bioanalytical methods are validated according to international guidelines. Eflornithine (DFMO) is a chiral drug, used for treating human African trypanosomiasis. A bioanalytical method for determination of DFMO enantiomers in plasma is presented. The enantiomers are detected by evaporative light-scatteri

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2

Cai, Xiaohan. "¿¿¿¿¿¿Development of Bioanalytical Methods for Clinical Applications and Drug Screening." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1314982525.

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3

Hendriks, Gert. "Theoretical models in bioanalytical method development development and use of theoretical models in pharmaceutical bioanalysis of small molecules /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irsw.ub.rug/nl/ppn/316.

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4

Ali, Mohsin [Verfasser]. "Bioanalytical method performance verification concept for cardiovascular research in pediatrics: From development to application in clinical trials / Mohsin Ali." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1205544135/34.

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5

Pihlblad, Alma. "Development and comparison of bioanalytical methods to measure free analyte." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413669.

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Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. In this project, several immunoassays were developed for the bioanalytical methods Gyrolab and ELISA to measure free analyte, where the biotherapeutics Avastin® and Lucentis®, and the ligand VEGF were used as analytes. One difference between the methods is the short contact time of

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6

Kunati, Sandeep Reddy. "DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919.

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7

Gorityala, Shashank. "TARGETED AND UNTARGETED OMICS FOR DISEASE BIOMARKERS USING LC-MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1547093694357568.

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8

Feng, Ye. "DEVELOPMENT OF QUANTITATIVE BIOANALYTICAL METHODS FOR THE PHARMACOLOGICAL STUDIES OF ANTI-CANCER DRUGS." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1392249778.

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9

Römsing, Susanne. "Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131519.

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This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. Developed methods were validated according to international guidelines. Melatonin is a hormone secreted by the pineal gland with a robust circadian rhythm. Bioanalytical methods for determination of melatonin in plasma and saliva have been developed which were used for monitoring melatonin levels in volu

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10

LIPARI, Elisa. "DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497430.

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Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the bio

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11

McCulloch, Melissa. "Development of Quantitative Bioanalytical Methods for the Measurement of Pharmaceutical Compounds via HPLC-UV and HPLC-MS/MS." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1255046678.

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12

Feuerstein, Delphine. "Development and use of bioanalytical instrumentation and signal analysis methods for rapid sampling microdialysis monitoring of neuro-intensive care patients." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5649.

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This thesis focuses on the development and use of analysis tools to monitor brain injury patients. For this purpose, an online amperometric analyzer of cerebral microdialysis samples for glucose and lactate has been developed and optimized within the Boutelle group. The initial aim of this thesis was to significantly improve the signal-to-noise ratio and limit of detection of the assay to allow reliable quantification of the analytical data. The first approach was to re-design the electronic instrumentation of the assay. Printed-circuit boards were fabricated and proved very low noise, stable

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13

SINGH, LOVELY. "ANALYTICAL AND BIOANALYTICAL METHOD DEVELOPMENT OF MONOMETHYL FUMARATE AND ITS APPLICATION FOR PHARMACOKINETIC STUDY." Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18362.

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Monomethyl fumarate is the pharmacologically active metabolite of immune modulator dimethyl fumarate. It is used f0r the treatment 0f relapsing f0rms 0f multiple scler0sis, relapsing-remitting disease, and active sec0ndary pr0gressive disease, in adults. The maj0r 0bjective 0f this thesis was t0 devel0p selective and sensitive meth0d f0r HPLC and LCMS analysis 0f MMF, t0 study its pharmac0kinetics in rat plasma. The chr0mat0graphic separati0n was achieved 0n a HYPERSIL GOLD, 50 ×4.6 mm,5u C18 by using a 70:30 (v/v) mixture 0f acet0nitrile and 10mM amm0nium f0rmate as the m0bile p

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14

Choi, Yong Seok. "The development of new nanoelectrospray techniques and a noble stable isotope labeling method for bioanalytical mass spectrometry." 2007. http://proquest.umi.com/pqdweb?did=1397910281&sid=3&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on Feb. 15, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Wood, Troy D. Includes bibliographical references.

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15

Caufield, William Vincent. "Development and validation of stability indicating high performance liquid chromatography methods for the analysis of selected pharmaceuticals in intravenous fluid mixtures ; development and validation of bioanalytical high performance liquid chromatography methods for the analysis of selected pharmaceuticals." 2002. http://purl.galileo.usg.edu/uga%5Fetd/caufield%5Fwilliam%5Fv%5F200205%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2002.<br>Directed by William Vincent Caufield. Includes articles published in Chromatographia, and an article accepted by Journal of liquid chromatography and related technologies. Includes bibliographical references.

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