Academic literature on the topic 'Bioanalytical methods'

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Journal articles on the topic "Bioanalytical methods"

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Woltman, Steven J. "Bioanalytical methods." TrAC Trends in Analytical Chemistry 15, no. 5 (1996): VI. http://dx.doi.org/10.1016/0165-9936(96)80634-0.

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Anjani, M. Nikhare* R. T. Lohiya S. W. Rangari M. J. Umekar. "An Overview of the Development and Validation of Bioanalytical Methods using HPLC." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 319–25. https://doi.org/10.5281/zenodo.14045042.

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A key component of successful drug development is the creation of sensitive, dependable, and selective bioanalytical techniques for the quantitative assessment of medications and their metabolites in biological matrices. The pharmacokinetic and toxicokinetic analyses of investigational new drug applications (INDs), new drug applications (NDAs), and abbreviated new drug applications (ANDAs) all require the data gathered from these techniques. Critical judgments supporting a drug's safety and efficacy are based on the findings of human clinical trials, including bioavailability and bioequivalenc
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Skrzydlewska, Elżbieta. "Bioanalytical Methods in Toxicology." Toxicology Mechanisms and Methods 18, no. 6 (2008): 453. http://dx.doi.org/10.1080/15376510802156655.

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Hartmann, C., J. Smeyers-Verbeke, D. L. Massart, and R. D. McDowall. "Validation of bioanalytical chromatographic methods." Journal of Pharmaceutical and Biomedical Analysis 17, no. 2 (1998): 193–218. http://dx.doi.org/10.1016/s0731-7085(97)00198-2.

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Labuda, Ján, Richard P. Bowater, Miroslav Fojta, et al. "Terminology of bioanalytical methods (IUPAC Recommendations 2018)." Pure and Applied Chemistry 90, no. 7 (2018): 1121–98. http://dx.doi.org/10.1515/pac-2016-1120.

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AbstractRecommendations are given concerning the terminology of methods of bioanalytical chemistry. With respect to dynamic development particularly in the analysis and investigation of biomacromolecules, terms related to bioanalytical samples, enzymatic methods, immunoanalytical methods, methods used in genomics and nucleic acid analysis, proteomics, metabolomics, glycomics, lipidomics, and biomolecules interaction studies are introduced.
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Van Emon, Jeanette M. "Bioanalytical Methods for Food Contaminant Analysis." Journal of AOAC INTERNATIONAL 93, no. 6 (2010): 1681–91. http://dx.doi.org/10.1093/jaoac/93.6.1681.

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Abstract Foods are complex mixtures of lipids, carbohydrates, proteins, vitamins, organic compounds, and other naturally occurring substances. Sometimes added to this mixture are residues of pesticides, veterinary and human drugs, microbial toxins, preservatives, contaminants from food processing and packaging, and other residues. This milieu of compounds can pose difficulties in the analysis of food contaminants. There is an expanding need for rapid and cost-effective residue methods for difficult food matrixes to safeguard our food supply. Bioanalytical methods are established for many food
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Gleason, Carol R., Qin C. Ji, and Enaksha R. Wickremsinhe. "Evaluation of correlation between bioanalytical methods." Bioanalysis 12, no. 6 (2020): 419–26. http://dx.doi.org/10.4155/bio-2020-0019.

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Bioanalytical methods evolve throughout clinical development timelines, resulting in the need for establishing equivalency or correlation between different methods to enable comparison of data across different studies. This is accomplished by the conduct of cross validations and correlative studies to compare and describe the relationship. The incurred sample reanalysis acceptance criterion seems to be adopted universally for cross validations and correlative studies; however, this does not identify any trends or biases between the two methods (datasets) being compared. Presented here are grap
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Singh, Anamika, and Tamanna Narsinghan. "BIOANALYTICAL METHOD VALIDATION: A COMPREHENSIVE ASSESSMENT OF VARIOUS REGULATORY GUIDELINES." Indian Drugs 60, no. 06 (2023): 7–25. http://dx.doi.org/10.53879/id.60.06.12583.

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Bioanalytical methods are used to analyse an analyte in a biological matrix. Bioanalytical method validation is the process of determining the suitability of the given bioanalytical methodology for providing the required analytical data. Validation of the bioanalytical methods demonstrates and ensures that the methods used for the quantification of analyte in biological fluids are reliable, reproducible and suitable for its intended application. Different regulatory agencies like Food and Drug administration (FDA), The National Health Surveillance Agency or Agência Nacional de Vigilância Sanit
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Jordan, Gregor, and Roland F. Staack. "Toward comparability of anti-drug antibody assays: is the amount of anti-drug antibody–reagent complexes at cut-point (CP-ARC) the missing piece?" Bioanalysis 12, no. 14 (2020): 1021–31. http://dx.doi.org/10.4155/bio-2020-0143.

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Immunogenicity testing is a mandatory and critical activity during the development of therapeutic proteins. Multiple regulatory guidelines provide clear recommendations on appropriate immunogenicity testing strategies and required bioanalytical assay performances. Unfortunately, it is still generally accepted that a comparison of the immunogenicity of different compounds is not possible due to apparent performance differences of the used bioanalytical methods. In this perspective, we propose the ‘cut-point anti-drug antibody–reagents complex’ (CP-ARC) concept for technical comparability of the
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Waikar, Sakshi S., Manisha Raut, Tejashree Dugaje, Vasim T. Pathan, Atul R. Bendale, and Anil G. Jadhav. "Extensive assessment of fundamental factors in the development and validation of bioanalytical methods: Highlighting accuracy and reliability." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 4 (2024): 274–80. https://doi.org/10.18231/j.ijpca.2024.040.

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Bioanalysis is a pivotal method employed in the pharmaceutical industry for the quantitative analysis of drugs and their metabolites within biological samples. It plays a crucial role in various aspects of pharmaceutical research, including bioequivalence, pharmacokinetic, and toxicokinetic studies. Method development, validation, and sample analysis are integral components of bioanalytical processes, ensuring the accuracy and reliability of results. Throughout each stage of analysis, careful evaluation is required to identify and mitigate any potential sources of interference, such as environ
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Dissertations / Theses on the topic "Bioanalytical methods"

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Cannan, Susan. "Microelectrode methods for bioanalytical and biophysical applications." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397013.

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Brown, Stacy D., and Tyler C. Melton. "Trends in Bioanalytical Methods for Club Drugs: 2000-2010." Digital Commons @ East Tennessee State University, 2011. https://doi.org/10.1002/bmc.1549.

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The term 'club drug' can be loosely defined as any substance used to enhance social settings. Such drugs are commonly found at raves or similar all-night dance parties and include methamphetamine, 3,4-methylenedioxymethamphetamine, gamma-hydroxybutyrate (GHB), ketamine (KET), and flunitrazepam (FLU). These drugs have potentially dangerous side effects including hallucinations, paranoia, amnesia and hyperthermia. In addition, GHB, KET and FLU are considered predatory drugs due to their roles in drug-facilitated sexual assault. Forensic and regulatory agencies routinely have the need for determi
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Pihlblad, Alma. "Development and comparison of bioanalytical methods to measure free analyte." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413669.

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Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. In this project, several immunoassays were developed for the bioanalytical methods Gyrolab and ELISA to measure free analyte, where the biotherapeutics Avastin® and Lucentis®, and the ligand VEGF were used as analytes. One difference between the methods is the short contact time of
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Cai, Xiaohan. "¿¿¿¿¿¿Development of Bioanalytical Methods for Clinical Applications and Drug Screening." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1314982525.

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Kunati, Sandeep Reddy. "DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919.

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Feng, Ye. "DEVELOPMENT OF QUANTITATIVE BIOANALYTICAL METHODS FOR THE PHARMACOLOGICAL STUDIES OF ANTI-CANCER DRUGS." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1392249778.

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Deupree, Susan M. Schoenfisch Mark H. "Bioanalytical methods for investigating bacterial adhesion and the antibacterial action of nitric oxide." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2314.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 26, 2009). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry Biological Chemistry." Discipline: Chemistry; Department/School: Chemistry.
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Römsing, Susanne. "Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131519.

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This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. Developed methods were validated according to international guidelines. Melatonin is a hormone secreted by the pineal gland with a robust circadian rhythm. Bioanalytical methods for determination of melatonin in plasma and saliva have been developed which were used for monitoring melatonin levels in volu
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LIPARI, Elisa. "DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497430.

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Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the bio
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Atherton, Adrian Ashley. "Nonlinear wave-mixing spectroscopic methods for bioanalytical and biophysical applications with sensitive detection at the single cell level." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3230037.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2006.<br>Title from first page of PDF file (viewed November 17, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Books on the topic "Bioanalytical methods"

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Vogel, Patric U. B. Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0.

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Van Emon, Jeanette M., 1956-, ed. Immunoassay and other bioanalytical techniques. CRC Press/Taylor & Francis, 2007.

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Christine T. C. Fook Sheung. The applicability of ASTED/HPLC to the development of bioanalytical methods. De Montfort University, 1996.

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Barceló, Damià. Biosensors for the environmental monitoring of aquatic systems: Bioanalytical and chemical methods for endocrine disruptors. Springer, 2009.

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Vogel, Patric U. B. Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden GmbH, 2022.

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Methods of Biochemical Analysis: Bioanalytical Instrumentation. Wiley-Interscience, 1993.

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Validation of Bioanalytical Methods and Document Bioequivalence (ANDA). CRC Press LLC, 1999.

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Biopolymer Mass Spectrometry: Methods, Ion Chemistry, Bioanalytical Applications. Wiley & Sons, Limited, John, 2018.

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Wells, David Ames, and Wells David. High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies. Elsevier Science & Technology Books, 2003.

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High Throughput Bioanalytical Sample Preparation - Methods and Automation Strategies. Elsevier, 2003. http://dx.doi.org/10.1016/s1464-3456(03)x8001-1.

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Book chapters on the topic "Bioanalytical methods"

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Stead, Sara, and Jacques Stark. "Bioanalytical Screening Methods." In Chemical Analysis of Antibiotic Residues in Food. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118067208.ch5.

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Vogel, Patric U. B. "Validation of Bioanalytical Methods." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_5.

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Vogel, Patric U. B. "Method Categories." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_2.

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Rup, Bonita, Corinna Krinos-Fiorotti, Boris Gorovits, and Hendrik Neubert. "Bioanalytical Methods and Immunogenicity Assays." In Biophysical Methods for Biotherapeutics. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118354698.ch8.

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Vogel, Patric U. B. "Validation Parameters." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_3.

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Vogel, Patric U. B. "Validation Environment and Validation Planning." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_4.

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Vogel, Patric U. B. "Introduction." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_1.

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Vogel, Patric U. B. "Summary." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_7.

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Vogel, Patric U. B. "Errors, Problems and Risks Associated with Insufficient Method Validation." In Validation of Bioanalytical Methods. Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-38913-0_6.

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Loos, Walter J., Peter de Bruijn, and Alex Sparreboom. "Bioanalytical Methods in Clinical Drug Development." In Principles of Anticancer Drug Development. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7358-0_3.

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Conference papers on the topic "Bioanalytical methods"

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Narayanan, Narasimhachari, Garrick Little, Ramesh Raghavachari, and Gabor Patonay. "New near-infrared dyes for applications in bioanalytical methods." In Photonics West '95, edited by Joseph R. Lakowicz. SPIE, 1995. http://dx.doi.org/10.1117/12.208471.

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Lin, Hao, Rajiv Bharadwaj, Juan G. Santiago, and Bijan Mohammadi. "A High-Fidelity Electrokinetic Flow Model for the Prediction of Electrophoregrams in On-Chip Eletrophoresis Applications." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79439.

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On-chip electrophoresis is a growing field with increasing chemical and bioanalytical applications such as genomics and proteomics. The use of multicomponent and heterogeneous electrolyte configurations can often lead to complex flow behavior. In this work, we present a high-fidelity, low computational cost electrokinetic flow model for the modeling and optimization of electrophoretic separations. The model adopts a depth-averaged approach that captures convective-dispersion processes, and includes important physical effects such as electrical body force and fully nonlinear multi-species elect
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Lytle, Fred E. "Identification of Bacterial Pathogens by Laser Excited Fluorescence." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.ma7.

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Aminopeptidase profiling is an established bioanalytical technique used for the identification of bacterial pathogens. This method is based on the production of highly fluorescent β-naphthylamine (BNA) through aminopeptidase hydrolysis of a series of nonfluorescent L-aminoacid-β-naphthylamide substrates by the microorganism of interest. The resultant profiles used to make the identification are bar graphs of the extent of hydrolysis of the substrate versus the identity of the nutrient. The shape of the plot is indicative of the pathogen.
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Spadafora, Debora, Manuel Daldin, Elisa Marchegiani, et al. "D002 Development of a new bioanalytical method for selective measurement of wild-type Huntingtin in human cerebrospinal fluid." In EHDN and Enroll-HD 2024 abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jnnp-2024-ehdn.78.

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Yedlapalli, Govindarao, and Y. Ganesh Kumar. "Optimization of Bioanalytical Liquid Chromatography - Tandem Mass Spectrometric Method for Quantification of Tazemetostat: An Epithelioid Sarcoma Treatment Drug in Human Plasma." In 2023 12th International Conference on System Modeling & Advancement in Research Trends (SMART). IEEE, 2023. http://dx.doi.org/10.1109/smart59791.2023.10428339.

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RÜBENSAM, Gabriel, and Henrique Bordin Lucena BORGES. "VALIDATION OF A GC-FID METHODOLOGY FOR THE DETERMINATION OF 2,5-HEXANEDIONE IN URINE." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.33_abstract_borges.pdf.

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2,5-hexanedione is the main metabolite of hexane and methyl butyl ketone excreted into urine and is currently used to estimate the human exposure levels to these solvents in professional environments. In Brazil, occupational exposure is regulated by a national control program (PCMSO) and applied to public and private organizations that hire your employees according to the actual Brazilian legislation. In the present work, we validated a methodology based on a gas chromatography−flame ionization detector (GC-FID) for the quantification of 2,5-hexanedione in urine to attend the new occupational
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Castro, SM, LA Azevedo, S. Eller, et al. "DESENVOLVIMENTO DE MÉTODO ANALÍTICO PARA DETERMINAÇÃO DE ANTIEPILÉPTICOS EM AMOSTRAS DE SORO POR LC-MS/MS." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8134.

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Objetivo: A terapia farmacológica com antiepilépticos (AE) apresenta faixa terapêutica estreita, de forma que é necessária a dosagem de AE em soro, a fim de proceder com a monitorização terapêutica e promover melhor resultado clínico. Atualmente, os principais métodos de análise de AE se baseiam em testes imunoquímicos, cujos resultados apresentam seletividade e especificidade limitados. Este estudo tem como objetivo desenvolver e validar método de determinação de quatro antiepilépticos usados tradicionalmente na clínica e presentes na RENAME (ácido valproico, carbamazepina, fenitoína e fenoba
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