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Dissertations / Theses on the topic 'Bioanalytical methods'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Cannan, Susan. "Microelectrode methods for bioanalytical and biophysical applications." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397013.

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2

Brown, Stacy D., and Tyler C. Melton. "Trends in Bioanalytical Methods for Club Drugs: 2000-2010." Digital Commons @ East Tennessee State University, 2011. https://doi.org/10.1002/bmc.1549.

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The term 'club drug' can be loosely defined as any substance used to enhance social settings. Such drugs are commonly found at raves or similar all-night dance parties and include methamphetamine, 3,4-methylenedioxymethamphetamine, gamma-hydroxybutyrate (GHB), ketamine (KET), and flunitrazepam (FLU). These drugs have potentially dangerous side effects including hallucinations, paranoia, amnesia and hyperthermia. In addition, GHB, KET and FLU are considered predatory drugs due to their roles in drug-facilitated sexual assault. Forensic and regulatory agencies routinely have the need for determi

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3

Pihlblad, Alma. "Development and comparison of bioanalytical methods to measure free analyte." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413669.

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Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. In this project, several immunoassays were developed for the bioanalytical methods Gyrolab and ELISA to measure free analyte, where the biotherapeutics Avastin® and Lucentis®, and the ligand VEGF were used as analytes. One difference between the methods is the short contact time of

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4

Cai, Xiaohan. "¿¿¿¿¿¿Development of Bioanalytical Methods for Clinical Applications and Drug Screening." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1314982525.

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5

Kunati, Sandeep Reddy. "DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919.

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6

Feng, Ye. "DEVELOPMENT OF QUANTITATIVE BIOANALYTICAL METHODS FOR THE PHARMACOLOGICAL STUDIES OF ANTI-CANCER DRUGS." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1392249778.

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7

Deupree, Susan M. Schoenfisch Mark H. "Bioanalytical methods for investigating bacterial adhesion and the antibacterial action of nitric oxide." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2314.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 26, 2009). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry Biological Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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8

Römsing, Susanne. "Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131519.

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This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. Developed methods were validated according to international guidelines. Melatonin is a hormone secreted by the pineal gland with a robust circadian rhythm. Bioanalytical methods for determination of melatonin in plasma and saliva have been developed which were used for monitoring melatonin levels in volu

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9

LIPARI, Elisa. "DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497430.

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Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the bio

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10

Atherton, Adrian Ashley. "Nonlinear wave-mixing spectroscopic methods for bioanalytical and biophysical applications with sensitive detection at the single cell level." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3230037.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2006.<br>Title from first page of PDF file (viewed November 17, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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11

McCulloch, Melissa. "Development of Quantitative Bioanalytical Methods for the Measurement of Pharmaceutical Compounds via HPLC-UV and HPLC-MS/MS." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1255046678.

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12

Charkiewicz, Elzbieta [Verfasser]. "Identification of antioxidant active trace element proteins in animal cells and human cell lines using bioanalytical methods / Elzbieta Charkiewicz." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1028496818/34.

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13

Feuerstein, Delphine. "Development and use of bioanalytical instrumentation and signal analysis methods for rapid sampling microdialysis monitoring of neuro-intensive care patients." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5649.

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This thesis focuses on the development and use of analysis tools to monitor brain injury patients. For this purpose, an online amperometric analyzer of cerebral microdialysis samples for glucose and lactate has been developed and optimized within the Boutelle group. The initial aim of this thesis was to significantly improve the signal-to-noise ratio and limit of detection of the assay to allow reliable quantification of the analytical data. The first approach was to re-design the electronic instrumentation of the assay. Printed-circuit boards were fabricated and proved very low noise, stable

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14

Noreen, Razia. "FTIR imaging of collagens in gliomas." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14316/document.

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Le gliome est le type le plus agressif et mortel de tumeur cérébrale. Ces tumeurs se caractérisent par la présence conjointe de phénotypes solides (de bas grade, moins invasif, hautement vascularisé) et diffus (haut grade, très envahissant et diffus) des glioblastomes multiformes. Les collagènes sont des composants majeurs de la MEC des cellules tumorales des gliomes, et sont également présents dans la membrane basale des vaisseaux sanguins, mais avec une composition différente entre vasculatures saine et tumorale. L'abondance et la typologie des collagènes dans la MEC des cellules tumorales e

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15

Hassan, Rabeay Younes Abdelfattah [Verfasser], and Ursula [Akademischer Betreuer] Bilitewski. "Bioanalytical Studies on the Effects of Chemical Compounds on the Respiratory Chain of Candida albicans focusing on Electrochemical Methods / Rabeay Younes Abdelfattah Hassan ; Betreuer: Ursula Bilitewski." Braunschweig : Technische Universität Braunschweig, 2011. http://d-nb.info/117582528X/34.

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16

Wang, Bo. "Novel statistical methods for evaluation of metabolic biomarkers applied to human cancer cell lines." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1399046331.

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17

Zhou, Mowei. "Incorporation of Surface Induced Dissociation into a Commercial Ion Mobility - Tandem Mass Spectrometer and Application of Mass Spectrometry Methods for Structural Analysis of Non-covalent Protein Complexes." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373977026.

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18

Malm, Mikaela. "Drug Analysis : Bioanalytical Method Development and Validation." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8547.

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This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. Developed bioanalytical methods are validated according to international guidelines. Eflornithine (DFMO) is a chiral drug, used for treating human African trypanosomiasis. A bioanalytical method for determination of DFMO enantiomers in plasma is presented. The enantiomers are detected by evaporative light-scatteri

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19

Medeiros, Francinalva Dantas de. "Investigação da influência da velocidade de liberação do fármaco metoprolol a partir da forma farmacêutica sobre seu processo de absorção e de seus enantiômeros." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-04042014-113927/.

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A Agência Nacional de Vigilância Sanitária (ANVISA) não exige a realização de ensaios de bioequivalência utilizando métodos enantiosseletivos de quantificação de fármacos para o registro de medicamentos genéricos ou similares contendo fármacos racêmicos. Porém, existe a possibilidade das diferenças de concentrações plasmáticas dos enantiômeros entre o medicamento referência e os genéricos e/ou similares comercializados no Brasil serem maiores que as estabelecidas pelos limites de bioequivalência. Esse estudo teve a finalidade de investigar a influência da velocidade de liberação do fármaco met

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20

Carmical, Jennifer, and Stacy D. Brown. "The Impact of Phospholipids and Phospholipid Removal on Bioanalytical Method Performance." Digital Commons @ East Tennessee State University, 2016. https://doi.org/10.1002/bmc.3686.

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Phospholipids (PLs) are a component of cell membranes, biological fluids and tissues. These compounds are problematic for the bioanalytical chemist, especially when PLs are not the analytes of interest. PL interference with bioanalysis highly impacts reverse-phase chromatographic methods coupled with mass spectrometric detection. Phospholipids are strongly retained on hydrophobic columns, and can cause significant ionization suppression in the mass spectrometer, as they out-compete analyte molecules for ionization. Strategies for improving analyte detection in the presence of PLs are reviewed,

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21

Yao, Seydou. "Imagerie IRTF de haute résolution des interactions cellules-fibres pour l'étude des effets pathogènes des amiantes." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14611/document.

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Les maladies pulmonaires tel que l’amiantose ou le mésotheliome proviennent de l‘interaction entre les fibres d’amiantes et les cellules humaines. L’hétérogénéité morphologique et chimique des fibres nous oblige à disposer de moyens analytique capable d’analyser l’interaction organique – inorganique. Nos travaux ont pour but de développer une méthodologie d'imagerie infrarouge couplé avec le rayonnement synchrotron. Grâce à cette technique, nous pourrons analyser les effets des fibres d'amiantes sur une cellule unique. La méthodologie a été testée sur des cellules cultivées directement sur des

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22

Hendriks, Gert. "Theoretical models in bioanalytical method development development and use of theoretical models in pharmaceutical bioanalysis of small molecules /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irsw.ub.rug/nl/ppn/316.

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23

Ali, Mohsin [Verfasser]. "Bioanalytical method performance verification concept for cardiovascular research in pediatrics: From development to application in clinical trials / Mohsin Ali." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1205544135/34.

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24

Oliveira, Maysa Aparecida de. "Obtenção e caracterização química e farmacocinética do produto de fotodegradação do nifedipino." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/8672.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2018-07-09T16:12:59Z No. of bitstreams: 2 Tese- Maysa Aparecida de Oliveira - 2013.pdf: 2303389 bytes, checksum: d6b1b0186001f327c5e50809b8d401fb (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-10T11:10:17Z (GMT) No. of bitstreams: 2 Tese- Maysa Aparecida de Oliveira - 2013.pdf: 2303389 bytes, checksum: d6b1b0186001f327c5e50809b8d401fb (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Mad

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25

Gorityala, Shashank. "TARGETED AND UNTARGETED OMICS FOR DISEASE BIOMARKERS USING LC-MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1547093694357568.

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26

Shah, Kumar. "Quantitative Analysis of Tobacco Specific Nitrosamine in Human Urine Using Molecularly Imprinted Polymers as a Potential Tool for Cancer Risk Assessment." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1954.

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Measuring urinary tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide conjugate may provide the best biomarker of tobacco smoke lung carcinogen metabolism. Existence of differences in the extent of NNAL metabolism rates may be potentially related to an individuals’ lung cancer susceptibility. Low concentrations of NNAL in smokers urine (<1 ng/mL) require sensitive and selective methods for analysis. Traditionally, this involves extensive, time-consuming sample preparation that limits throughput and adds to measurement variability. Molecularly i

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27

Caufield, William Vincent. "Development and validation of stability indicating high performance liquid chromatography methods for the analysis of selected pharmaceuticals in intravenous fluid mixtures ; development and validation of bioanalytical high performance liquid chromatography methods for the analysis of selected pharmaceuticals." 2002. http://purl.galileo.usg.edu/uga%5Fetd/caufield%5Fwilliam%5Fv%5F200205%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2002.<br>Directed by William Vincent Caufield. Includes articles published in Chromatographia, and an article accepted by Journal of liquid chromatography and related technologies. Includes bibliographical references.

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28

SINGH, LOVELY. "ANALYTICAL AND BIOANALYTICAL METHOD DEVELOPMENT OF MONOMETHYL FUMARATE AND ITS APPLICATION FOR PHARMACOKINETIC STUDY." Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18362.

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Monomethyl fumarate is the pharmacologically active metabolite of immune modulator dimethyl fumarate. It is used f0r the treatment 0f relapsing f0rms 0f multiple scler0sis, relapsing-remitting disease, and active sec0ndary pr0gressive disease, in adults. The maj0r 0bjective 0f this thesis was t0 devel0p selective and sensitive meth0d f0r HPLC and LCMS analysis 0f MMF, t0 study its pharmac0kinetics in rat plasma. The chr0mat0graphic separati0n was achieved 0n a HYPERSIL GOLD, 50 ×4.6 mm,5u C18 by using a 70:30 (v/v) mixture 0f acet0nitrile and 10mM amm0nium f0rmate as the m0bile p

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29

Choi, Yong Seok. "The development of new nanoelectrospray techniques and a noble stable isotope labeling method for bioanalytical mass spectrometry." 2007. http://proquest.umi.com/pqdweb?did=1397910281&sid=3&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on Feb. 15, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Wood, Troy D. Includes bibliographical references.

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30

Meirinho, Sara Alexandra. "Bioanalytical method validation of Venlafaxine and Desvenlafaxine in mouse plasma, brain and liver using a MEPS/HPLC assay: a path to study these drugs’ intranasal administration." Master's thesis, 2015. http://hdl.handle.net/10400.6/6438.

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The present thesis was elaborated aiming to obtain the master’s degree in pharmaceutical sciences. In here, it is described all the scientific investigation work done to reach the proposed objective, as well as all tasks and learnings that I have taken along my community and hospital pharmacy internships. Chapter 1 is related with my scientific investigation work entitled “Bioanalytical method validation of Venlafaxine and Desvenlafaxine in mouse plasma, brain and liver using a MEPS/HPLC assay: a path to study these drugs’ intranasal administration”. Since major depressive disorder is one of t

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31

Batista, Diana Patricia Goncalves. "Administração de alergénios da pele na prevenção da doença de Alzheimer: avaliação farmacocinética pré-clínica." Master's thesis, 2021. http://hdl.handle.net/10316/99126.

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Dissertação de Mestrado em Farmacologia Aplicada apresentada à Faculdade de Farmácia<br>Alzheimer's disease (AD) is a neurodegenerative disorder, frequently associated with advancing age. Its global incidence has been increasing dramatically and significant efforts have been made to develop new methods of treatment. However, there are still no available treatments for all patients that effectively slow or block disease progression. Thus, the discovery of innovative therapeutic approaches for the prevention or treatment of AD is necessary. A skin allergen was identified as an activator of the t

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