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Dissertations / Theses on the topic 'Bioassay-guided fractionation'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 January 2023

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1

Mianda, Mutombo Sephora. "Isolation of antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus sp. through bioassay-guided fractionation." Diss., University of Pretoria, 2019. http://hdl.handle.net/2263/77853.

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Ancistrocladus is the only genus in the Ancistrocladaceae family and together with the closely related Dioncophyllaceae, they produce naphthylisoquinoline (NIQ) alkaloids. This class of compounds exhibits a very interesting large spectrum of bioactivities. Some of these compounds have shown very promising antiplasmodial activity. Leaves of an as yet unidentified Ancistrocladus sp collected in the region of Bonsolerive (Northwestern part of DRC), were investigated for their antiplasmodial activity. They were air dried at room temperature and ground. The ground plant material was extracted seque

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2

Jia, Xuegang. "Optimization methods for analytical separations : MALDI, dynamic IEF and bioassay guided fractionation /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1650505471&sid=13&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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3

Mokwelu, Onyinye Vivian. "Bioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatum." University of the Western Cape, 2019. http://hdl.handle.net/11394/6975.

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Magister Pharmaceuticae - MPharm<br>Due to the contribution of hypertension to various cardiovascular diseases, many studies are currently focused on identifying efficient bioactive compounds with antihypertensive activity and thus reducing the levels of cardiovascular disease. ACE inhibitors are an important component of the therapeutic regimen for treating hypertension, but due to the increase in the prevalence of side effects of synthetic compounds, alternative and complementary medicines which may consist of pure bioactive compound or a combination of various compounds from natural sources

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4

Abrahams, Meryl Arlene. "Bioassay-guided fractionation of Artemisia afra for in vitro antimalarial activity against Plasmodium falciparum." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26263.

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With the increase in recent years in the prevalence of malaria, and in drug resistance of Plasmodium falciparum, there has been much interest in natural plant products for new antimalarials with novel modes of action against Plasmodium. Artemisinin or Qinghaosu is one such antimalarial isolated from a Chinese herb, Anemisia annua (Asteraceae) and it is currently undergoing phase I and II clinical trials. The Southern African species, Artemisia afra (African wormwood, wildeals, lengana) is commonly used by local traditional healers for symptoms of malaria, in particular fever. Thus it seemed ap

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5

Sevak, Hamel P. "Potential chemical defenses against diatom fouling in macroalgae from the Antarctic Peninsula insights from bioassay guided fractionation /." Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2009m/sevak.pdf.

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6

Wilson, Shannon Courtney. "Applications and Advancements of Dynamic Isoelectric Focusing." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/865.

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The work in the dissertation expands the applications of DIEF and describes the development of incorporating DIEF in a microfluidic chip to create a comprehensive proteomics tool. Proof-of-concept DIEF experiments have been done previously, so the focus of this work is to explore the capabilities of DIEF. Dynamic isoelectric focusing (DIEF) is a separation technique invented by Dr. Luke Tolley. It is similar to capillary isoelectric focusing except it uses four high voltage electrodes to form a pH gradient instead of only two. The additional two electrodes are able to manipulate the pH gra

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7

Segopa, Ellen Kelebogile. "Marine bacteria as a potential source for novel antimicrobial compounds." University of the Western Cape, 2021. http://hdl.handle.net/11394/7918.

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>Magister Scientiae - MSc<br>The high rate of rediscovery of known compounds has led to a decline in the discovery of novel natural products. The high biodiversity of organisms growing in extreme conditions such as oceans has led to the increased interest by researchers for their use as a source of novel natural products. Marine bacteria are known for their extensive biosynthetic capacity to produce diverse natural products, which are suitable for various biotechnology applications such as in agriculture, for treatment of fungal plant pathogens, and as antibiotics, for treatment of bacterial i

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Marion, Zachary Harrison. "Ecological efficacy of chemically-mediated antipredator defenses in the Eastern newt Notophthalmus viridescens." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34856.

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Frogs, toads, and salamanders are well known for harboring an array of distasteful (and poisonous) secondary metabolites, presumably as antipredator defenses; yet few experiments have rigorously demonstrated the efficacy of amphibian chemical defenses against ecologically relevant consumers. For example, despite an absence of rigorous statistical evidence showing their distastefulness to predators, eastern newts (Notophthalmus viridescens (Rafinesque))--a common salamander in lentic North American habitats--are assumed to tolerate diverse predator assemblages because newts secrete tetrodotoxin

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9

Neves, Michelline Viviane Marques das. "Fracionamento biomonitorado da própolis vermelha de Igarassu, Pernambuco, Brasil." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/6840.

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Made available in DSpace on 2015-05-14T13:00:09Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 6176997 bytes, checksum: 84882ba9517a6db053cc7c655b0e9d39 (MD5) Previous issue date: 2014-08-25<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Propolis is an heterogeneous mixture of substances, produced by melliferous bees from plants in close proximity with the bee´s hives. It is usually classified according to its botanical origin and chemical composition that vary according to geographical origin. Studies have shown that red propolis have physicochemical and biol

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10

Segopa, Ellen Kelebogile. "Marine bacteria as a potential source for novel antimicrobial compounds." University of the Western Cape, 2020. http://hdl.handle.net/11394/7828.

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>Magister Scientiae - MSc<br>The high rate of rediscovery of known compounds has led to a decline in the discovery of novel natural products. The high biodiversity of organisms growing in extreme conditions such as oceans has led to the increased interest by researchers for their use as a source of novel natural products. Marine bacteria are known for their extensive biosynthetic capacity to produce diverse natural products, which are suitable for various biotechnology applications such as in agriculture, for treatment of fungal plant pathogens, and as antibiotics, for treatment of bacterial i

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11

Naman, Charles Benjamin. "Phytochemical Investigation of the Medicinal Plant Taxodium distichum and Library Screening of Thalictrum Alkaloids for New Antileishmanial Drug Leads." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429283826.

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12

Peti, Ana Paula Ferranti. "Identificação de agentes antimicrobianos produzidos por actinobactérias de solo com potencial aplicação no controle da mastite bovina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-08072016-165557/.

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Neste trabalho foi explorado o potencial das actinobactérias como produtoras de agentes antimicrobianos contra bactérias causadoras da mastite bovina. Para este fim, foram otimizados dois diferentes bioensaios um de antagonismo e o outro de antibiose, contra 13 bactérias Gram-positivas e Gram-negativas relacionadas a mastite bovina. Através do bioensaio de antagonismo 120 actinobactérias foram triadas, sendo 55% delas consideradas ativas. Para o ensaio de antibiose foram triados 70 extratos brutos e 60% mostram a formação de halos de inibição. Os extratos brutos Caat 1-54, Caat 2-63 e Caat 8-2

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13

Brochini, Cláudia Barbosa. "Terpenos de Guarea guidonia (Meliaceae) e fracionamento de extratos vegetais biomonitorado por linhagens mutantes de Saccharomyces cerevisiae)." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-10102014-122847/.

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Da fração hexânica do extrato metanólico das folhas de Guarea guidonia (Meliaceae), foram isolados os diterpenos: [11S-(1α,2E,6E,10α)]-3,7,11-trimetil-11-(4-metil-pent-3-en-1-i1)biciclo[8.1.0]undeca-2,6-dieno e [1S(1aβ,4aα,7aβ,7bβ)]-decaidro-1,7-dimetil-1-(4-metil-pent-3-en-1-il)-4-metilen-1H-cicloprop[e]azulen-7-ol, já descritos na literatura, além de dois novos isômeros de [1S-(1aβ,4aα,7aβ, 7aβ)]-decaidro-1,7-dimetil-1-(2-hidroxi-4-metil-pent-3-en-1-il)-4metilen-1H-cicloprop[e]azulen-7-ol. No óleo essencial obtido das folhas do mesmo espécime

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14

Pheiffer, Fazlin. "Investigating the antimicrobial potential of Thalassomonas actiniarum." University of Western Cape, 2020. http://hdl.handle.net/11394/7995.

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Philosophiae Doctor - PhD<br>The World Health Organisation predicts that by the year 2050, 10 million people could die annually as a result of infections caused by multidrug resistant bacteria. Individuals with compromised immune systems, caused by underlying disease such as HIV, MTB and COVID-19, are at a greater risk. Antibacterial resistance is a global concern that demands the discovery of novel drugs. Natural products, used since ancient times to treat diseases, are the most successful source of new drug candidates with bioactivities including antibiotic, antifungal, anticancer, antiviral

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15

Blanco, Carcache Peter Josephin. "Chemical Characterization and Biological Evaluation of Secondary Metabolites Isolated from Glycosmis ovoidea." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1580383951030389.

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16

Rapado, Ludmila Nakamura. "Obtenção e avaliação da atividade de compostos isolados de Piper em modelos biológicos para o controle da esquistossomose mansônica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-21092012-104513/.

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A esquistossomose é incidente em países tropicais e subtropicais e o uso de moluscicidas é adequado para prevenir a infecção de pessoas. O objetivo deste estudo foi buscar compostos em Piper ativos em Biomphalaria glabrata e avaliar a atividade esquistossomicida e toxicidade do composto mais ativo. O fracionamento biomonitorado de Piper diospyrifolium resultou no isolamento da flavocavaína A e ácido 4-hidroxi-3-[3,7,11-trimetildodeca-2,6,10-trienil]benzoico. A busca de compostos também foi realizada em amidas e chalconas e dos oito compostos avaliados, quatro foram ativos, sendo a piplartina m

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17

Andraud-Dieu, Amandine. "Recherche de molécules antimicrobiennes d'origine lichénique : Etude phytochimique de trois lichens & approche synthétique de deux composés actifs." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0029/document.

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L’étude physicochimique de trois lichens récoltés en Limousin, Usnea florida, Flavoparmelia caperata et Cladonia incrassata, a permis d’isoler et de caractériser 16 composés issus du métabolisme secondaire. Dans un premier temps, ces lichens ont été sélectionnés lors d’un criblage analytique préliminaire réalisé sur 17 espèces. L’activité antimicrobienne des extraits acétoniques a été évaluée, puis leur fractionnement bioguidé a été mis en œuvre. Les deux isomères de l’acide usnique, 3 dibenzofuranes, 4 depsides, 3 depsidones, un acide aliphatique, un phtalide et un stérol ont été isolés. Une

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18

Conan, Cécile. "Metabolomics investigations of seaweed extracts used as plant growth biostimulants and transcriptomic studies of their physiological effects on A. thaliana." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066760.

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Développer une agriculture durable et respectueuse de l’environnement, implique l’utilisation de biostimulants tels que les extraits de macro-algues marines dans le but d’améliorer la croissance des plantes ainsi que leur tolérance aux stress biotiques et abiotiques. Ces extraits commerciaux d’algues sont utilisés en agriculture afin de favoriser la nutrition des plantes, d’améliorer leur qualité nutritionnelle et d’accroitre leur rendement. Dans ce domaine quelques modes d’action ont été élucidés par le centre R&D des Laboratoires Goëmar-Arysta. Cependant, jusqu’à présent, les matières ac

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19

Techer, Sophie. "Criblage d’activités biologiques de plantes endémiques ou indigènes de La Réunion - Recherche de molécules antivirales ciblant le virus du chikungunya." Thesis, La Réunion, 2013. http://www.theses.fr/2013LARE0014/document.

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Ce travail de thèse s'attache à identifier des plantes et/ou molécules à activités cytotoxique, antioxydante, anti-inflammatoire et antivirale ciblant le virus du chikungunya (CHIKV) dans le but de trouver des alternatives thérapeutiques vis-à-vis du stress oxydatif et de l'inflammation, mécanismes impliqués dans les maladies chroniques non transmissibles (diabète, obésité…), et de la maladie du chikungunya, maladie vectorielle réémergente. La première partie de ces travaux présente les résultats obtenus lors d'un criblage d'activités biologiques réalisé sur une sélection de dix-huit plantes e

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20

Hsu, Kuei-Ming, and 許貴明. "Bioassay-guided fractionation of anti-inflammatory components from residue of aqueous extract of Chinese olive." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/61846939870770993964.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>104<br>Chronic inflammation is one of the factors causing chronic disorders. Many secondary metabolites extracted from herbs exhibit both anti-oxidative and anti-inflammatory activities, and may have potential against inflammation-induced chronic diseases. Canarium album is a common herb and food with excellent anti-oxidative and hepatoprotective effects. Its ethyl acetate fraction from methanol extract has been proved to exhibit good anti-inflammatory potential in our previous work.The objective of this research is to use different isolation techniques to screen bi

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21

Elkins, Aaron. "Bioassay Guided Fractionation and Structural Elucidation of Environmental Attractants for Juvenile European Carp (Cyprinus carpio)." Phd thesis, 2021. http://hdl.handle.net/1885/242805.

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Pheromones, semiochemicals that trigger a natural response in a second member of the same species, have been extensively investigated across a variety of vertebrates and invertebrates to manipulate their behaviour. In aquatic species, these pheromones play important roles in larval settlement and metamorphosis, courtship and mating, and foraging. Pheromones responsible for the initiation of mating behaviour in carp and goldfish have been investigated extensively in sexually mature carp but there has been limited investigation on the role the environment plays on behaviour. The introduction of

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22

Holland, Ian P. "1. Dynamin-I inhibitors from sessile marine invertebrates; 2. Chemotaxonomy of Cystophora spp." Thesis, 2011. http://hdl.handle.net/1959.13/927961.

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Research Doctorate - Doctor of Philosophy (PhD)<br>A colourimetric GTPase assay was utilised to screen a marine natural products library of extracts with the goal of identifying novel dynamin-I inhibitors. Bioassay-guided fractionation of an active marine sponge (unknown Australian species) fraction led to the isolation of the methyl esters of eicosapentaenoic acid (EPA) (15) and Arachidonic acid (16). These compounds are structurally similar to the known dynamin-I inhibitors MiTMAB (1) and OcTMAB (2), however, 15 and 16 were inactive in the dynamin-I GTPase bioassay. An extract of another Aus

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23

Pujiastuti, Dwi Yuli, and 鄭優麗. "Screening of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Soft Shelled Turtle Yolk using Orthogonal Bioassay Guided Fractionation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/66047059141639463913.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>104<br>The renin-angiotensin-aldosteron system (RAAS) plays a prominent role in maintaining of blood pressure. Angiotensin-I converting enzyme inhibitory peptides is one of the key therapeutic targets for combating hypertension. This study was conducted to apply an orthogonal bioassay-guided fractionation to efficiently screen ACE inhibitory peptides from soft-shelled turtle yolk (TY). TY proteins were digested using various proteases followed by ultrafiltration (MWCO 3 kDa). The data indicated that thermolysin hydrolysate showed higher inhibition compared with the

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24

"In vitro and in vivo mechanistic studies of the wound-healing effects of Astragali Radix and phytochemical analysis of its active fractions/components isolated using bioassay-guided fractionation." 2013. http://library.cuhk.edu.hk/record=b5884429.

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Lai, Kwok Kin.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 229-251).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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25

Shang, Nan. "Bioassay-guided fractionation of Larix laricina du Roi, and antidiabetic potentials of ethanol and hot water extracts of seventeen medicinal plants from the traditional pharmacopeia of the James Bay Cree." Thèse, 2013. http://hdl.handle.net/1866/12626.

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Nous avons utilisé une approche ethnobotanique pour identifier des espèces de plantes utilisées par les Cris afin de traiter les symptômes du diabète de type 2. Larix laricina du Roi (L. laricina) a récemment été identifiée comme une des meilleures plantes qui a stimulé le transport de glucose dans les cellules C2C12 et fortement potentialisé la différenciation des 3T3-L1 en indiquant une sensibilité potentiellement accrue à l’insuline. Ensuite, ces études de criblage ont été effectuées sur des extraits éthanolique (EE) en utilisant une série de bioessais in vitro. Cependant, les préparations

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26

"Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights." Thesis, 2013. http://hdl.handle.net/10388/ETD-2013-06-1066.

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Activation of mammalian stress responsive pathways by plant secondary metabolites may contribute to the protection against certain chronic diseases afforded by fruit and vegetable consumption. This work focuses on the identification of plant compounds that activate the stress-responsive enzyme quinone reductase (QR) by stabilizing the transcription factor NF-E2 related factor-2 (Nrf2). Screening methanolic extracts of plants from Western Canada for QR induction in a mouse hepatoma cell line (Hepa-1c1c7) led to the identification of twenty-one extracts capable of doubling the activity of QR. Bi

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Bhuyan, Deep Jyoti. "Phytochemicals derived from Australian eucalypts as anticancer agents for pancreatic malignancies." Thesis, 2018. http://hdl.handle.net/1959.13/1388005.

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Research Doctorate - Doctor of Philosophy (PhD)<br>The poorest prognostic outcome for pancreatic cancer (PC) patients, among all gastrointestinal malignancies, can be attributed to the molecular heterogeneity and lack of specific therapeutic strategies. The emergence of resistance against the common chemotherapeutic drug gemcitabine has also been widely reported. Several studies have demonstrated improved efficacy using gemcitabine in conjunction with plant polyphenolics and antioxidants for PC treatment. This suggests that plant secondary metabolites should be investigated further in a search

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