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1

Niu, Siwen, Dong Liu, Zongze Shao, Peter Proksch, and Wenhan Lin. "Eutypellazines A–M, thiodiketopiperazine-type alkaloids from deep sea derived fungus Eutypella sp. MCCC 3A00281." RSC Advances 7, no. 53 (2017): 33580–90. http://dx.doi.org/10.1039/c7ra05774a.

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2

Verma, Ankita, B. N. Johri, and Anil Prakash. "Antagonistic Evaluation of Bioactive Metabolite from Endophytic Fungus, Aspergillus flavipes KF671231." Journal of Mycology 2014 (August 27, 2014): 1–5. http://dx.doi.org/10.1155/2014/371218.

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Of the total 40 endophytic fungi isolated from foliar tissues of medicinal plant Stevia rebaudiana Bertoni, a fungal isolate, Aspergillus flavipes, was subjected to bioassay guided fractionation. The fractionation was found active against medicinal plant pathogen Sclerotinia sclerotiorum with an inhibition zone of 29 mm in size. Further the metabolite was extracted which shows 20% growth inhibition in 24 h and 46% after 48 h, respectively. Bioassay guided chemical compound was identified as 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester. On the basis of morphological characters and rDN
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3

Uhlig, Silvio, Helene Wisløff, and Dirk Petersen. "Identification of Cytotoxic Constituents ofNarthecium ossifragumUsing Bioassay-Guided Fractionation." Journal of Agricultural and Food Chemistry 55, no. 15 (2007): 6018–26. http://dx.doi.org/10.1021/jf070776k.

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4

Li, Yong, Dong Liu, Zhongbin Cheng, Peter Proksch, and Wenhan Lin. "Cytotoxic trichothecene-type sesquiterpenes from the sponge-derived fungus Stachybotrys chartarum with tyrosine kinase inhibition." RSC Advances 7, no. 12 (2017): 7259–67. http://dx.doi.org/10.1039/c6ra26956g.

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5

López-Ogalla, Javier, Esther García-Palomero, Jorge Sánchez-Quesada, et al. "Bioactive prenylated phenyl derivatives derived from marine natural products: novel scaffolds for the design of BACE inhibitors." MedChemComm 5, no. 4 (2014): 474–88. http://dx.doi.org/10.1039/c3md00236e.

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Bioassay guided-fractionation of active extracts from the sponge Sarcotragus sp. led to the isolation biochemical characterization and development of a chemistry program of bioactive prenylated phenyl derivatives.
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6

Kim, Gyoung-Deuck, Jin Lee, and Joong-Hyuck Auh. "Metabolomic Screening of Anti-Inflammatory Compounds from the Leaves of Actinidia arguta (Hardy Kiwi)." Foods 8, no. 2 (2019): 47. http://dx.doi.org/10.3390/foods8020047.

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The metabolomic screening of potential anti-inflammatory compounds in the leaves of Actinidia arguta was performed by using LC-MS/MS. Ethanol extracts were prepared, and the anti-inflammatory effects were investigated based on nitric oxide (NO) synthesis and inducible nitric oxide synthase expression in lipopolysaccharide-induced RAW 264.7 macrophages. The 75% ethanol extract showed the highest inhibitory effect on nitric oxide (NO) production, and it was further separated by in vitro bioassay-guided fractionation using preparative LC with reversed-phase column separation. Through multiple ste
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Matos Lopes, Tamyris Regina, Fábio Rodrigues de Oliveira, Flávia Filocreão Malheiros, Marcieni Ataíde de Andrade, Marta Chagas Monteiro, and Ana Cristina Baetas Gonçalves. "Antimicrobial bioassay-guided fractionation of a methanol extract ofEupatorium triplinerve." Pharmaceutical Biology 53, no. 6 (2014): 897–903. http://dx.doi.org/10.3109/13880209.2014.948634.

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8

Finger, Daiane, Christiane Schinieder Machado, Yohandra Reyes Torres, et al. "Antifungal Bioassay-Guided Fractionation of an Oil Extract of Propolis." Journal of Food Quality 36, no. 5 (2013): 291–301. http://dx.doi.org/10.1111/jfq.12039.

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9

Melariri, Paula, William Campbell, Paschal Etusim, and Peter Smith. "Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts fromCarica papayaLeaves." Journal of Parasitology Research 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/104954.

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We investigated the antiplasmodial properties of crude extracts fromCarica papayaleaves to trace the activity through bioassay-guided fractionation. The greatest antiplasmodial activity was observed in the ethyl acetate crude extract.C. papayashowed a high selectivity forP. falciparumagainst CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chloroquine-resistant DD2 strains, respectively.Carica papayaethyl acetate extract was subjected to bioassay-guided fractionation to ascertain the most active fraction, which was purified and identified using high-
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10

Shahbazi, Behzad, Saba Feyzmand, Fataneh Jafari, et al. "Antidiabetic Potential of Prosopis farcta Roots: In Vitro Pancreatic Beta Cell Protection, Enhancement of Glucose Consumption, and Bioassay-Guided Fractionation." Evidence-Based Complementary and Alternative Medicine 2020 (January 20, 2020): 1–9. http://dx.doi.org/10.1155/2020/8048273.

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By using the streptozotocin- (STZ-) induced cytotoxicity in β-TC3 cells as an assay model, a bioassay-guided fractionation study was employed to isolate and characterize the potential antidiabetic principles of roots of Prosopis farcta. A combination of open column chromatography on reverse-phase silica gel using a water-ethanol gradient (10 : 90 to 100 : 0) followed by HPLC-based fractionation led to an active compound that appears to be composed of carbohydrate/sugar. When cell viability under STZ was reduced to 49.8 ± 4% (mean ± SD), treatment with the active compound at the concentration o
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11

Caesar, Lindsay, Joshua Kellogg, Olav Kvalheim, Richard Cech, and Nadja Cech. "Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei." Planta Medica 84, no. 09/10 (2018): 721–28. http://dx.doi.org/10.1055/a-0590-5223.

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AbstractBotanical medicines have been utilized for centuries, but it remains challenging to identify bioactive constituents from complex botanical extracts. Bioassay-guided fractionation is often biased toward abundant or easily isolatable compounds. To comprehensively evaluate active botanical mixtures, methods that allow for the prioritization of active compounds are needed. To this end, a method integrating bioassay-guided fractionation, biochemometric selectivity ratio analysis, and molecular networking was devised and applied to Angelica keiskei to comprehensively evaluate its antimicrobi
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12

Dettweiler, Micah, Lewis Marquez, Max Bao, and Cassandra L. Quave. "Quantifying synergy in the bioassay-guided fractionation of natural product extracts." PLOS ONE 15, no. 8 (2020): e0235723. http://dx.doi.org/10.1371/journal.pone.0235723.

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13

Uhlig, Silvio, Helene Wisløff, and Dirk Petersen. "Identification of Cytotoxic Constituents of Narthecium ossifragum Using Bioassay-Guided Fractionation." Journal of Agricultural and Food Chemistry 56, no. 6 (2008): 2297. http://dx.doi.org/10.1021/jf8004433.

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14

Uhlig, Silvio, Arno C. Gutleb, Ulf Thrane, and Arne Flåøyen. "Identification of cytotoxic principles from Fusarium avenaceum using bioassay-guided fractionation." Toxicon 46, no. 2 (2005): 150–59. http://dx.doi.org/10.1016/j.toxicon.2005.03.005.

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15

Brillatz, T., E. Ferreira Queiroz, L. Marcourt, M. Jacmin, AD Crawford, and JL Wolfender. "Anticonvulsant agents from Boswellia sacra identified by zebrafish bioassay-guided fractionation." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596567.

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16

Khalil, Noha, Mohamed Ashour, Abdel Naser Singab, and Osama Salama. "Bioassay guided fractionation and cytotoxic activity of Daucus carota var. boissieri." Future Journal of Pharmaceutical Sciences 4, no. 1 (2018): 14–17. http://dx.doi.org/10.1016/j.fjps.2017.07.002.

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17

Militão, Gardenia C. G., Sávio M. Pinheiro, Ivana N. F. Dantas, et al. "Bioassay-guided fractionation of pterocarpans from roots of Harpalyce brasiliana Benth." Bioorganic & Medicinal Chemistry 15, no. 21 (2007): 6687–91. http://dx.doi.org/10.1016/j.bmc.2007.08.011.

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18

Samy, Mamdouh Nabil, Basma Khalaf Mahmoud, Nourhan Hisham Shady, Usama Ramadan Abdelmohsen, and Samir Anis Ross. "Bioassay-Guided Fractionation with Antimalarial and Antimicrobial Activities of Paeonia officinalis." Molecules 27, no. 23 (2022): 8382. http://dx.doi.org/10.3390/molecules27238382.

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Bioassay-guided fractionation technique of roots of Paeonia officinalis led to isolation and structure elucidation of seven known compounds, including four monoterpene glycosides: lactiflorin (1), paeoniflorin (4), galloyl paeoniflorin (5), and (Z)-(1S,5R)-β-pinen-10-yl β-vicianoside (7); two phenolics: benzoic acid (2) and methyl gallate (3); and one sterol glycoside: β-sitosterol 3-O-β-D-glucopyranoside (6). The different fractions and the isolated compounds were evaluated for their antimicrobial and antimalarial activities. Fraction II and III showed antifungal activity against Candida neof
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19

Lee, Shoei-Sheng, Yue Xi, Chien-Kuang Chen, Ching-Chia Chang, and Sheng-Fa Tsai. "A Novel 3,4-Secocycloartane Triterpene, Bearing a Tetrahydropyran Moiety, from Pasania formosana Leaf." Natural Product Communications 11, no. 8 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100811.

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Bioassay guided fractionation against α-glucosidase and separation of the ethanolic extract of Pasania formosana leaf by chromatographic methods led to the isolation of a novel secocycloartane triterpene. This compound, named pasasecocycloartenoic acid, was elucidated as 21,24( R)-epoxy-25-hydroxy-3,4-secocycloart-4(28)-en-3-oic acid through analysis of 1D and 2D NMR spectra and on the basis of HRESIMS data. The compound showed weak activity against α-glucosidase, but its poor solubility hampered the bioassay.
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20

Suliman Mohamed, Malik, Mona Timan Idriss, Amgad I. M. Khedr, et al. "Activity of Aristolochia bracteolata against Moraxella catarrhalis." International Journal of Bacteriology 2014 (September 28, 2014): 1–6. http://dx.doi.org/10.1155/2014/481686.

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A bioassay-guided fractionation of methanol extract of Aristolochia bracteolata whole plant was carried out in order to evaluate its antimicrobial activity and to identify the active compounds in this extract. Antibacterial and antifungal activities of methanol extract against gram-positive, gram-negative, and fungal strains were investigated by the agar disk diffusion method. Among the strains tested, Moraxella catarrhalis and sea urchin-derived Bacillus sp. showed the highest sensitivity towards the methanol extract and hence they are used as test organisms for the bioassay-guided fractionat
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21

Gadallah, Adel S., Mujeeb-ur-Rehman, Atta-ur-Rahman, et al. "Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study." Molecules 25, no. 13 (2020): 2994. http://dx.doi.org/10.3390/molecules25132994.

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Natural products have served as primary remedies since ancient times due to their cultural acceptance and outstanding biodiversity. To investigate whether Tamarix aphylla L. modulates an inflammatory process, we carried out bioassay-guided isolation where the extracts and isolated compounds were tested for their modulatory effects on several inflammatory indicators, such as nitric oxide (NO), reactive oxygen species (ROS), proinflammatory cytokine; tumour necrosis factor (TNF-α), as well as the proliferation of the lymphocyte T-cells. The aqueous ethanolic extract of the plant inhibited the in
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22

Jamil, Maryam, Ihsan ul Haq, Bushra Mirza, and Mazhar Qayyum. "Isolation of antibacterial compounds from Quercus dilatata L. through bioassay guided fractionation." Annals of Clinical Microbiology and Antimicrobials 11, no. 1 (2012): 11. http://dx.doi.org/10.1186/1476-0711-11-11.

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23

Latif, A., DGI Kingston, SR Dalal, MB Cassera, and M. Goetz. "Bioassay guided fractionation of antimalarial extracts from plants used in traditional medicine." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596300.

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24

Eloff, J. N. "Quantification the bioactivity of plant extracts during screening and bioassay guided fractionation." Phytomedicine 11, no. 4 (2004): 370–71. http://dx.doi.org/10.1078/0944711041495218.

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25

Zhang, Xiaoxue, Feng Han, Ping Gao, Dong Yu, and Shigui Liu. "Bioassay-guided fractionation of antifertility components of castorbean (Ricinus communisL.) seed extracts." Natural Product Research 21, no. 11 (2007): 982–89. http://dx.doi.org/10.1080/14786410701371462.

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26

Yang, Xiaolong, D. Kristen Summerhurst, Susan F. Koval, Christine Ficker, Myron L. Smith, and Mark A. Bernards. "Isolation of an antimicrobial compound fromImpatiens balsamina L. using bioassay-guided fractionation." Phytotherapy Research 15, no. 8 (2001): 676–80. http://dx.doi.org/10.1002/ptr.906.

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27

Cunha, Luís C. S., Sérgio A. L. de Morais, Francisco J. T. de Aquino, et al. "Bioassay-guided fractionation and antimicrobial and cytotoxic activities of Cassia bakeriana extracts." Revista Brasileira de Farmacognosia 27, no. 1 (2017): 91–98. http://dx.doi.org/10.1016/j.bjp.2016.08.002.

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28

Nachar, Abir, Melinda Vinqvist, Lina Musallam, et al. "Elucidation of Glucose Homeostasis and Bioassay-Guided Fractionation of Fermented Blueberry Juice." Canadian Journal of Diabetes 37 (October 2013): S68. http://dx.doi.org/10.1016/j.jcjd.2013.08.207.

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29

Mohd Lazim, M. I., M. A. Mohd Asri, A. Abdul Ghani, N. S. N. Ramli, N. A. Sani, and D. L. Abd. Razak. "Bioassay-guided fractionation of mushroom (Schizophyllum commune) extract using vacuum column chromatography." Food Research 6, Supplementary 2 (2023): 163–70. http://dx.doi.org/10.26656/fr.2017.6(s2).027.

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This study was carried out to evaluate the tyrosinase inhibition activity, which represents anti-pigmentation/browning property and bioactive compounds of sub-fractions of Schizophyllum commune extracts. In this study, two types of crude extracts, namely K4C and K30C, were subjected to chromatographic fractionation in vacuum column chromatography packed with silica gel. The columns were stepwise eluted with different ratios of solvent acetone: methanol (A:M) to obtain several fractions. Anti-pigmentation activity was measured by tyrosinase inhibition assay. The fraction with the highest activi
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30

Isaka, Masahiko, Amonlaya Jaturapat, Jarin Kramyu, Morakot Tanticharoen, and Yodhathai Thebtaranonth. "Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated from Streptomycesspectabilis BCC 4785." Antimicrobial Agents and Chemotherapy 46, no. 4 (2002): 1112–13. http://dx.doi.org/10.1128/aac.46.4.1112-1113.2002.

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ABSTRACT Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A1, and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 ± 0.0010 μg/ml, while its cytotoxicity was much weaker.
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31

Yamaguchi, Tatsuhiro, Kazufumi Toume, Midori A. Arai, Firoj Ahmed, Samir K. Sadhu, and Masami Ishibashi. "Phorbol Esters with Wnt Signal-Augmenting Effects Isolated from Excoecaria Indica." Natural Product Communications 7, no. 4 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700414.

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A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 – 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.
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32

Clark, Trevor N., Katelyn Ellsworth, Haoxin Li, John A. Johnson, and Christopher A. Gray. "Isolation of the Plant Hormone (+)-Abscisic acid as an Antimycobacterial Constituent of the Medicinal Plant Endophyte Nigrospora sp." Natural Product Communications 8, no. 12 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801203.

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An extract of the endophytic fungus Nigropsora sp. (isolate TC2-054) from the Canadian medicinal plant Fragaria virginiana exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation revealed that linoleic acid derivatives and the plant hormone (+)-abscisic acid (ABA) were responsible for the observed antimycobacterial activity. This activity of ABA has not been previously reported.
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33

Clark, Trevor N., Katelyn T. Ellsworth, Stephanie Jean, et al. "Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum." Natural Product Communications 10, no. 10 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001005.

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An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A (1) and 6(E’)-phomopsolide A (2). This is the first report of antimycobacterial activity for 1 and 2.
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Thanh, Nguyen Van, Nguyen Hai Dang, Phan Van Kiem, Nguyen Xuan Cuong, Hoang Thanh Huong, and Chau Van Minh. "A New Triterpene Glycoside from the Sea Cucumber Holothuria Scabra Collected in Vietnam." ASEAN Journal on Science and Technology for Development 23, no. 4 (2017): 253. http://dx.doi.org/10.29037/ajstd.113.

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Bioassay guided fractionation led to the isolation of a new triterpene glycoside, holothurinogenin B (1) along with three known compounds, holothurin B (2), holothurin A (3), and holothurin A2 (4), from the methanol extract of the Vietnamese sea cucumber Holothuria scabra. Their structures were deduced from the spectral analysis (1D-NMR, 2D-NMR, MS) and chemical evidences.
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35

Castro, Amaya, Charles L. Cantrell, Amber L. Hale, and Stephen O. Duke. "Phytotoxic Activity of Flavonoids from Dicranostyles Ampla." Natural Product Communications 5, no. 8 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500817.

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Crude extracts from over 16 species of plants from the family Convolvulaceae were evaluated for phytotoxic activity against Agrostis stolonifera (bentgrass) and Lactuca sativa (lettuce) at 1000 (μg/mL. Ethanol extracts of Dicranostyles ampla Ducke were among the most active of those species tested. Systematic bioassay-guided fractionation of the ethanol extract of the aerial parts from this species was performed to identify specifically the phytotoxic compounds. Two phytotoxic flavonoids, dihydromyricetin (1) and myricetin-3- O-α-rhamnoside or myricetrin (2), were found to be responsible for m
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36

Ribeiro, Alan Bezerra, Dulce Helena Siqueira Silva, and Vanderlan da Silva Bolzani. "Antioxidant flavonol glycosides from Nectandra grandiflora (Lauraceae)." Eclética Química 27, spe (2002): 35–44. http://dx.doi.org/10.1590/s0100-46702002000200004.

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The bioassay-guided fractionation of the ethanol extract from Nectandra grandiflora leaves led to the isolation of two flavonol glycosides which inhibited the bleaching of beta -carotene on the TLC assay. Both compounds had their molecular structures elucidated by means of extensive use of uni- and bidimensional NMR techniques and were identified as 3-O-beta -rhamnosylkaempferol and 3-O-beta -rhamnosylquercetine.
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Redko, Flavia, María L. Clavin, Daniela Weber, Fernando Ranea, Timm Anke, and Virginia Martino. "Antimicrobial Isoflavonoids from Erythrina crista galli Infected with Phomopsis sp." Zeitschrift für Naturforschung C 62, no. 3-4 (2007): 164–68. http://dx.doi.org/10.1515/znc-2007-3-402.

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Abstract The isoflavonoids coumestrol, genistein and daidzein have been isolated and identified by bioassay-guided fractionation from the acetone extract of Erythrina crista galli young twigs infected with Phomopsis sp. These compounds showed antimicrobial activity against Bacillus brevis (MIC values 16.3, 64.8 and 137.8 μm, respectively). This is the first time that coumestrol, besides lutein and n-nonacosane, are reported in this species.
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Tantry, Mudasir A., and Aziz A. Rahman. "Amplexicine, an Antioxidant Flavan-3-ol from Polygonum amplexicaule." Natural Product Communications 6, no. 11 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601111.

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Bioassay guided fractionation of an ethanolic extract of Polygonum amplexicaule D. Don led to the isolation of amplexicine, a new flavan-3-ol (1), along with khellactone (2). The structure of the isolates was established by UV, IR, HRESI/MS and NMR, including 1D and 2D experiments. Compound 1 exhibited considerable antioxidant activity in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay.
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39

Santhirasegaram, Sinthujah, Suranga R. Wickramarachchi, Renuka N. Attanayake, et al. "A Novel Cytotoxic Compound From the Endolichenic Fungus, Xylaria psidii Inhabiting the Lichen, Amandinea medusulina." Natural Product Communications 15, no. 7 (2020): 1934578X2093301. http://dx.doi.org/10.1177/1934578x20933017.

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The lichen host, Amandinea medusulina, collected from mangrove habitats in Sri Lanka, and its associated endolichenic fungi were isolated and identified by rDNA-ITS sequence analysis and morphological features. One of the fungal strains frequently isolated from the lichen thalli was identified as Xylaria psidii. This study aimed at the isolation and identification of the cytotoxic compounds present in this fungus. Secondary metabolites of X. psidii were first extracted into ethyl acetate and subsequently subjected to bioassay-guided fractionation to isolate the bioactive compounds. Sulforhodam
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40

Vigbedor, Bright Yaw, Jonathan Osei-Owusu, Ralph Kwakye, and David Neglo. "Bioassay-Guided Fractionation, ESI-MS Scan, Phytochemical Screening, and Antiplasmodial Activity of Afzelia africana." Biochemistry Research International 2022 (April 13, 2022): 1–11. http://dx.doi.org/10.1155/2022/6895560.

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Background. Afzelia africana is a plant species with reported numerous medicinal potentials and secondary metabolites. Various parts of the plant have been applied for the treatment of hernia, rheumatism, pain, lumbago, malaria, etc. The study seeks to evaluate the phytochemical constituents, antiplasmodial, and ESI-MS scan of bioassay-guided fractions from the methanol extract of the bark of the plant. Aims. The main aim of the study was to carry out bioassay-guided fractionation of the crude methanol extract of Afzelia africana in order to isolate fractions and to evaluate their antiplasmodi
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41

Clark, Trevor N., Amanda I. Bishop, Mark McLaughlin, Larry A. Calhoun, John A. Johnson, and Christopher A. Gray. "Isolation of (–)–Avenaciolide as the Antifungal and Antimycobacterial Constituent of a Seimatosporium sp. Endophyte from the Medicinal Plant Hypericum perforatum." Natural Product Communications 9, no. 10 (2014): 1934578X1400901. http://dx.doi.org/10.1177/1934578x1400901022.

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An extract of Seimatosporium sp., an endophyte from the Canadian medicinal plant Hypericum perforatum, exhibited significant antifungal and antimycobacterial activity against Candida albicans and Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation led to the isolation of (-)–avenaciolide as the only bioactive constituent of the extract. This is the first report of both the antimycobacterial activity of avenaciolide and its isolation from a Seimatosporium sp. fungus.
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42

Fan, Jia-Jia, Xia Liu, Xi-Long Zheng, Hai Yu Zhao, Huan Xia, and Yi Sun. "A Novel Cytotoxic Physalin from Physalis angulata." Natural Product Communications 12, no. 10 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201016.

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Bioassay-guided fractionation from the whole plant of Physalis angulata led to the isolation of a novel physalin, 25-hydroxylisophysalin B (1), together with three megastigmane glucosides (2-4) and eight known physalins (5-12). The structure of compound 1 was elucidated by analysis of spectroscopic data. All of the compounds exhibited cytotoxic activities against MCF-7 human mammary cells and HepG2 human hepatoma cells.
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Ogungbe, Ifedayo V., Gabrielle M. Hill, Rebecca A. Crouch, et al. "Prenylated Isoflavonoids from Rhynchosia edulis." Natural Product Communications 6, no. 11 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601119.

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Four new prenylated isoflavones, rhynedulins A-C (1-3) and rhynedulinal (4), were isolated by bioassay-guided fractionation of the dichloromethane bark extract of Rhynchosia edulis. Five previously described compounds, scandenal, ulexin B, cajanone, cajanin, and cyclochandalone, were also isolated. These isoflavonoids showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei. They also have weak antiproliferative activity towards MCF-7 cells.
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Sudha, A., and P. Srinivasan. "Bioassay-Guided Isolation and Antioxidant Evaluation of Flavonoid Compound from Aerial Parts ofLippia nodifloraL." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/549836.

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The present study was designed to identify the DPPH (2, 2-diphenyl-1-picrylhydrazyl) free-radical scavenging constituents from methanol extract ofL. nodiflorausing bioassay-guided fractionation. The ethyl acetate fraction (EAF) revealed a strong antioxidant activity, compared to other fractions throughin vitroDPPH radical-scavenging assay. The repeated fractionation of active EAF by silica gel column chromatography yielded a compound with strong antioxidant potential. The isolated bioactive compound was determined as 2-(3, 4-dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one (5-hydroxy-3′,
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45

Mulula, A., and G. Mbiye. "HPLC Fingerprint Analysis with in - vitro Antimalarial Activity and Bioassay Guided Fractionation of Two Organic Extract from Ageratum conyzoides Leaves." International Journal of Science and Research (IJSR) 10, no. 10 (2021): 1471–76. http://dx.doi.org/10.21275/mr211026114726.

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Nuzzo, Genoveffa, Carmela Gallo, Fabio Crocetta, et al. "Identification of the Marine Alkaloid Lepadin A as Potential Inducer of Immunogenic Cell Death." Biomolecules 12, no. 2 (2022): 246. http://dx.doi.org/10.3390/biom12020246.

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Natural products and their synthetic analogs and derivatives are a traditional source of bioactive molecules with potential development as drug candidates. In this context, Marine Natural Products (MNPs) represent a rich reservoir of diverse molecular skeletons with potential pharmacological activity that, so far, has been mostly explored in cancer and infectious diseases. Starting from the development of a novel bioassay-guided screening platform for immunomodulatory compounds from an in-house MNPs library, we report the identification of the alkaloid lepadin A as a new model compound for imm
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Mishra, Satyaranjan, Saumya Ranjan Pani, Kedar Kumar Rout, Sukant Kumar Nayak, and Sabuj Sahoo. "Bioassay Guided Fractionation and Hepatoprotective Activity of Oleanolic Acid Acetate Isolated fromVitex negundoLinn." Journal of Biologically Active Products from Nature 4, no. 2 (2014): 89–100. http://dx.doi.org/10.1080/22311866.2013.868704.

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Frank, F. M., J. Ulloa, S. I. Cazorla, et al. "Trypanocidal Activity ofSmallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/627898.

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In order to find novel plant-derived biologically active compounds againstTrypanosoma cruzi, we isolated, from the organic extract ofSmallanthus sonchifolius, the sesquiterpene lactones enhydrin (1), uvedalin (2), and polymatin B (3) by bioassay-guided fractionation technique. These compounds showed a significant trypanocidal activity against the epimastigote forms of the parasite with IC50values of 0.84 μM (1), 1.09 μM (2), and 4.90 μM (3). After a 24 h treatment with 10 μg/mL of enhydrin or uvedalin, parasites were not able to recover their replication rate. Compounds1and2showed IC50values o
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Seida, Ahmed A., Nebal D. El Tanbouly, Wafaa T. Islam, Hanaa H. Eid, Shohda A. El Maraghy, and Amira S. El Senousy. "Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of pea by-product." Natural Product Research 29, no. 16 (2014): 1578–83. http://dx.doi.org/10.1080/14786419.2014.986123.

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Chandra Mohana, N., D. Rakshith, H. C. Yashavantha Rao, K. P. Ramesha, B. R. Nuthan, and S. Satish. "Bioassay guided fractionation of bioactive metabolite from Corynascus verrucosus inhabiting Croton bonplandianus Baill." Process Biochemistry 98 (November 2020): 106–12. http://dx.doi.org/10.1016/j.procbio.2020.07.007.

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