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1

Zhang, Y., and D. Donnelly. "In Vitro Bioassays as Indicators of Salinity Tolerance in Potato." HortScience 32, no. 3 (1997): 472A—472. http://dx.doi.org/10.21273/hortsci.32.3.472a.

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The relative salinity tolerance of three potato cultivars, including `Russet Burbank', `Kennebec', and `Norland', were compared using three in vitro bioassays (single node cuttings, root tip segments, and microtuberization) and yield data from field lysimeters irrigated with salinized water. The single-node cutting bioassay was simpler to perform than the root tip segment and microtuberization bioassays. The single-node cutting bioassay can be recommended as a substitute for more laborintensive and costly field assessments of salinity effects on yield.
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2

Sjödin, Lars, Thore Nederman, Per Anders Olsson, and Eila Viitanen. "In-vitro Bioassays for Cholecystokinin." Journal of Pharmacy and Pharmacology 41, no. 6 (1989): 402–6. http://dx.doi.org/10.1111/j.2042-7158.1989.tb06486.x.

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3

Neale, Peta A., Werner Brack, Selim Aït-Aïssa, et al. "Solid-phase extraction as sample preparation of water samples for cell-based and other in vitro bioassays." Environmental Science: Processes & Impacts 20, no. 3 (2018): 493–504. http://dx.doi.org/10.1039/c7em00555e.

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4

Matthiessen, J. N., and M. A. Shackleton. "Advantageous attributes of larval whitefringed weevil, Naupactus leucoloma (Coleoptera: Curculionidae) for bioassaying soil fumigants, and responses to pure and plant-derived isothiocyanates." Bulletin of Entomological Research 90, no. 4 (2000): 349–55. http://dx.doi.org/10.1017/s000748530000047x.

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AbstractFirst instars of the soil-inhabiting whitefringed weevil, Naupactus leucoloma(Boheman), are a particularly good bioassay model for assessing volatile soil fumigants and biofumigants. Eggs are readily obtained and can be stored for long periods with larvae hatched on demand and the first instar is non-feeding, surviving without food or shelter. Longevity varies with temperature, but readily accommodates the period required to conduct bioassays without appreciable mortality of untreated controls. In vitro bioassays of pure methyl isothiocyanate, the active ingredient from metham sodium s
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5

MARKIEWICZ, LESZEK, and ERLIO GURPIDE. "In Vitro Bioassays for Hormonal Activities." Annals of the New York Academy of Sciences 828, no. 1 Uterus, The (1997): 95–102. http://dx.doi.org/10.1111/j.1749-6632.1997.tb48526.x.

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6

Rose, MP, and RE Gaines-Das. "Characterisation, calibration and comparison by international collaborative study of international standards for the calibration of therapeutic preparations of FSH." Journal of Endocrinology 158, no. 1 (1998): 97–114. http://dx.doi.org/10.1677/joe.0.1580097.

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Therapeutic preparations of FSH, used primarily for treatment of infertility, are calibrated by in vivo bioassay against international standards (IS) derived from different sources deemed appropriate to their use according to pharmacopoeial monographs. Menotrophins, which have been used for several decades to treat infertility, have been calibrated against the IS for urinary FSH and LH (ISU) but are now being replaced by highly purified urinary FSH or rDNA-derived FSH (rFSH). The aim of this study was to evaluate two preparations of human rFSH and one preparation of highly purified urinary FSH
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7

Manger, Ronald L., Linda S. Leja, Sue Y. Lee, et al. "Detection of Paralytic Shellfish Poison by Rapid Cell Bioassay: Antagonism of Voltage-Gated Sodium Channel Active Toxins in vitro." Journal of AOAC INTERNATIONAL 86, no. 3 (2003): 540–43. http://dx.doi.org/10.1093/jaoac/86.3.540.

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Abstract Although cytotoxicity assays provide several advantages over mouse bioassays, sodium channel-blocking marine toxins, such as those associated with paralytic shellfish poison (PSP), require prolonged incubation periods of 24–48 h. This is in marked contrast to in vitro detection of sodium channel-enhancing marine toxins such as ciguatoxins or brevetoxins which can be accomplished in as few as 4–6 h. We developed a modified PSP cell bioassay that is as rapid as in vitro methods for sodium channel-enhancing toxins. The cell bioassay is based on a saxitoxin-dependent antagonism of the rap
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8

Layman, Lawrence C., Adriana L. A. Porto, Jun Xie та ін. "FSHβ Gene Mutations in a Female with Partial Breast Development and a Male Sibling with Normal Puberty and Azoospermia". Journal of Clinical Endocrinology & Metabolism 87, № 8 (2002): 3702–7. http://dx.doi.org/10.1210/jcem.87.8.8724.

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FSH is a dimeric pituitary glycoprotein hormone that regulates gonadal function. Human mutations in the FSHβ gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited. To date, no patients with partial or complete pubertal development due to FSHβ mutations have been documented in humans. We describe and characterize affected siblings, a male and a female, with evidence of pubertal development due to homozygosity for a Tyr76X nonsense mutation in the FSHβ gene. In vitro analysis of this mutant demonstrates unmeasurable FSH b
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9

Sundstrom, G., T. Sawyer, O. Hutzinger, and S. Safe. "In vitro bioassays for toxic polychlorinated azobenzenes." Chemosphere 15, no. 9-12 (1986): 2105–7. http://dx.doi.org/10.1016/0045-6535(86)90524-2.

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10

Yu, Xiaoqin, Yang Zhang, Mingjun Yang, et al. "Cytotoxic effects of tebufenozide in vitro bioassays." Ecotoxicology and Environmental Safety 129 (July 2016): 180–88. http://dx.doi.org/10.1016/j.ecoenv.2016.03.025.

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11

Markiewicz, Leszek, Joan Garey, Herman Adlercreutz, and Erlio Gurpide. "In vitro bioassays of non-steroidal phytoestrogens." Journal of Steroid Biochemistry and Molecular Biology 45, no. 5 (1993): 399–405. http://dx.doi.org/10.1016/0960-0760(93)90009-l.

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12

Holland, P. T. "Analysis of endocrine active substances in food and the environment." Pure and Applied Chemistry 75, no. 11-12 (2003): 1843–57. http://dx.doi.org/10.1351/pac200375111843.

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A critical review is made of techniques for analysis of residues of endocrine active substances (EASs) including sampling, extraction cleanup and determination based on GC/MS, LC/MS, ELISA, and bioassays. The growing importance of receptor-based in vitro bioassays is highlighted for integrated monitoring of environmental levels of certain classes of EASs and for establishing exposures. Some recent advances in methods of analysis for each of the key classes of EASs are summarized including for organochlorines, PCBs, dioxins and dioxin-like substances, polybrominated diphenyl ethers, phenolic xe
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13

van den Heuvel, Michael R., Pierre H. Martel, Tibor G. Kovacs, et al. "Evaluation of Short-Term Fish Reproductive Bioassays for Predicting Effects of a Canadian Bleached Kraft Mill Effluent." Water Quality Research Journal 45, no. 2 (2010): 175–86. http://dx.doi.org/10.2166/wqrj.2010.021.

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Abstract Under the Canadian Environmental Effects Monitoring (EEM) program for pulp and paper effluents, the observation of a national response pattern of decreased gonad size and increased fish condition and liver size has triggered a centralized multiagency investigation of cause (IOC) of reproductive impacts in fishes. The purpose of the component of the IOC study presented here is to compare a number of fish bioassays for determining reproductive and reproductive-endocrine effects of a bleached kraft mill effluent. The bleached kraft mill chosen for this study had demonstrated the national
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14

Storring, P. L., and Gaines Das R. E. "The International Standard for Pituitary FSH: Collaborative study of the Standard and of four other purified human FSH preparations of differing molecular composition by bioassays, receptor assays and different immunoassay systems." Journal of Endocrinology 123, no. 2 (1989): 275–93. http://dx.doi.org/10.1677/joe.0.1230275.

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ABSTRACT The International Standard for Pituitary FSH (IS; in ampoules coded 83/575) was assayed in terms of the Second International Reference Preparation of Human Pituitary FSH and LH for Bioassay (IRP 78/549) by 27 laboratories in 13 countries using bioassays, receptor assays and immunoassays. Estimates of the FSH content of the IS by in-vivo bioassay were homogeneous both within and between laboratories and gave a combined geometric mean (with 95% fiducial limits) of 79·9 (74·6–85·4) i.u./ampoule. Estimates by different in-vitro bioassays and receptor assays were also homogeneous between a
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15

Harrison, Howard F., Joseph K. Peterson, Christopher A. Clark, and Maurice E. Snook. "Sweetpotato Periderm Components Inhibit In Vitro Growth of Root Rotting Fungi." HortScience 36, no. 5 (2001): 927–30. http://dx.doi.org/10.21273/hortsci.36.5.927.

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Sweetpotato [Ipomoea batatas (L.) Lam.] periderm components were tested for their effect on four fungi that infect sweetpotato roots: Fusarium oxysporum Schlecht. f. sp. batatas (Wollenw.) Snyd. & Hans. and F. solani (Sacc.) Mart., both of which cause stem and root disease; and Lasiodiplodea theobromae (Pat.) Griffon & Maubl. and Rhizopus stolonifer (Ehr. ex Fr.) Lind., both of which cause storage root disease. Sequential extracts of `Regal' sweetpotato periderm with hexane, methanol, and 50% methanol were inhibitory to the four fungi when incorporated into potato dextrose agar medium
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16

Neale, Peta A., Jake W. O’Brien, Lisa Glauch, et al. "Wastewater treatment efficacy evaluated with in vitro bioassays." Water Research X 9 (December 2020): 100072. http://dx.doi.org/10.1016/j.wroa.2020.100072.

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17

Fischer, Fabian C., Luise Henneberger, Maria König, et al. "Modeling Exposure in the Tox21 in Vitro Bioassays." Chemical Research in Toxicology 30, no. 5 (2017): 1197–208. http://dx.doi.org/10.1021/acs.chemrestox.7b00023.

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18

Agarwal, Amit, Prashanth D'Souza, T. Sudhakar Johnson, Shekhar M. Dethe, and CV Chandrasekaran. "Use of in vitro bioassays for assessing botanicals." Current Opinion in Biotechnology 25 (February 2014): 39–44. http://dx.doi.org/10.1016/j.copbio.2013.08.010.

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19

Neale, Peta A., and Beate I. Escher. "In vitro bioassays to assess drinking water quality." Current Opinion in Environmental Science & Health 7 (February 2019): 1–7. http://dx.doi.org/10.1016/j.coesh.2018.06.006.

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20

Storring, P. L., and R. E. Gaines Das. "The International Standard for Recombinant DNA-derived Erythropoietin: collaborative study of four recombinant DNA-derived erythropoietins and two highly purified human urinary erythropoietins." Journal of Endocrinology 134, no. 3 (1992): 459–84. http://dx.doi.org/10.1677/joe.0.1340459.

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ABSTRACT The International Standard (IS) for Recombinant DNA-Derived (rDNA) Erythropoietin (EPO) (in ampoules coded 87/684) and three other rDNA EPO preparations in ampoules coded 87/690, 87/696 and 88/574 respectively, were compared with two preparations of highly purified human urinary (HU) EPO and the 2nd International Reference Preparation of Human Urinary Erythropoietin for Bioassay (2nd IRP) by 26 laboratories in 11 countries using a wide range of in-vivo and in-vitro bioassays and immunoassays. These EPO preparations were also compared by electrophoresis and isoelectric focusing. Estima
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21

Tsonis, C. G., A. S. McNeilly, and D. T. Baird. "Measurement of exogenous and endogenous inhibin in sheep serum using a new and extremely sensitive bioassay for inhibin based on inhibition of ovine pituitary FSH secretion in vitro." Journal of Endocrinology 110, no. 2 (1986): 341–52. http://dx.doi.org/10.1677/joe.0.1100341.

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ABSTRACT An extremely sensitive and reliable bioassay for inhibin based on inhibition of ovine pituitary FSH secretion in vitro was developed and used to measure exogenous and endogenous inhibin activity in the ewe. The sheep inhibin bioassay is 30- to 40-fold more sensitive than conventional rat inhibin bioassays. The minimum sensitivity of each bioassay in the measurement of inhibin activity in 1 ml of sheep serum is 220 mu. and 4080 mu. in the sheep and rat bioassays respectively. This sensitive inhibin bioassay has permitted, for the first time, the measurement of endogenous inhibin in the
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22

Storring, P. L., and R. E. Gaines Das. "The second International Standard for Human Pituitary LH: its collaborative study by bioassays and immunoassays." Journal of Endocrinology 138, no. 2 (1993): 345–59. http://dx.doi.org/10.1677/joe.0.1380345.

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ABSTRACT The second International Standard for Human Pituitary LH (in ampoules coded 80/552; 2nd IS) and LH 81/535 (prepared in the same way as the 2nd IS from the same LH preparation) were compared with the International Reference Preparation of Human Pituitary LH for Immunoassay (IRP 68/40) by 19 laboratories in 11 countries, using in-vivo and in-vitro bioassays, a receptor assay and immunoassays. Geometric mean estimates of the LH content of the 2nd IS (with 95% fiducial limits) in terms of IRP 68/40 were: 34·6 (29·1–41·0) IU/ampoule by in-vivo bioassays; 35·8 (27·0–47·4) IU/ampoule by in-v
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23

Sakai, Shin-ichi, Hidetaka Takigami, Kazunori Hosoe, and Peter Behnisch. "In Vitro Bioassays for Dioxin and Dixin-like Compounds." Waste Management Research 14, no. 1 (2003): 34–50. http://dx.doi.org/10.3985/wmr.14.34.

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24

Roy, P., M. Alevizaki, and I. Huhtaniemi. "In vitro bioassays for androgens and their diagnostic applications." Human Reproduction Update 14, no. 1 (2007): 73–82. http://dx.doi.org/10.1093/humupd/dmm038.

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25

Zhang, Yanling, and Danielle J. Donnelly. "In vitro bioassays for salinity tolerance screening of potato." Potato Research 40, no. 3 (1997): 285–95. http://dx.doi.org/10.1007/bf02358010.

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26

Safe, S., G. Mason, K. Farrell, et al. "Validation of in vitro bioassays for 2,3,7,8-TCDD equivalents." Chemosphere 16, no. 8-9 (1987): 1723–28. http://dx.doi.org/10.1016/0045-6535(87)90157-3.

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27

Habtemariam, Solomon. "Applying New Science for Old Medicines: Targeting Leukocyte-Endothelial Adhesions by Antiinflammatory Herbal Drugs." Natural Product Communications 5, no. 8 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500839.

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During the last two decades, considerable progress has been made in understanding the molecular mechanisms of the various leukocytes and endothelial cell adhesion molecules (cell adhesion molecules - CAMs) involved in cell-cell and cell matrix interactions. This understanding has opened up a new avenue of novel chemotherapeutic targets and bioassay models for inflammatory diseases. Recently developed In Vitro bioassays on leukocyte/endothelial cell adhesions can now offer rapid and inexpensive assessment methods for herbal medicines with claimed antiinflammatory uses. Through the use of these
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28

Petit, F., P. Le Goff, JP Cravedi, Y. Valotaire, and F. Pakdel. "Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures." Journal of Molecular Endocrinology 19, no. 3 (1997): 321–35. http://dx.doi.org/10.1677/jme.0.0190321.

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A relation between the chemical structure of a xenobiotic and its steroidal action has not yet been clearly established. Thus, it is not possible to define the estrogenic potency of different xenobiotics. An assessment may be accomplished by the use of different bioassays. We have previously developed a yeast system highly and stably expressing rainbow trout estrogen receptor (rtER) in order to analyze the biological activity of the receptor. The recombinant yeast system appears to be a reliable, rapid and sensitive bioassay for the screening and determination of the direct interaction between
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29

Ferrer, Rosa María Giménez, Joseph C. Scheerens, and W. Alan Erb. "In Vitro Screening of 76 Strawberry Cultivars for Twospotted Spider Mite Resistance." HortScience 28, no. 8 (1993): 841–44. http://dx.doi.org/10.21273/hortsci.28.8.841.

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Leaf disk bioassays based on oviposition and damage accrued during 72 hours were used to screen 76 strawberry (Fragaria spp.) cultivars for resistance to the twospotted spider mite (Tetranychus urticae Koch). Oviposition rates (eggs/female per day) and damage scores were both highly variable, allowing cultivars to be classified, according to a combination of these two variables, into six categories of susceptibility or resistance: highly susceptible- `Canoga', `Ozark Beauty', `Scott', and `Tangi'; resistant—'Aiko', `Annapolis', `Apollo', `Bounty', `Cardinal', `Douglas', `Dover', `Fairfax', `Fe
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30

Lafeber, F. P., M. P. Herrmann-Erlee, G. Flik, and S. E. Wendelaar Bonga. "Rainbow trout hypocalcin stimulates bone resorption in embryonic mouse calvaria in vitro in a PTH-like fashion." Journal of Experimental Biology 143, no. 1 (1989): 165–75. http://dx.doi.org/10.1242/jeb.143.1.165.

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Hypocalcin, the major hormone with hypocalcaemic action in fish, was isolated from trout corpuscles of Stannius (SCs). The bioactivity of hypocalcin was assessed in a parathyroid hormone (PTH) bioassay involving bone resorption in embryonic mouse calvaria. Calcium and phosphate release and lactate production were stimulated in a dose-dependent manner by hypocalcin. On a molar basis about equal amounts of hypocalcin and PTH were required to obtain similar effects in this assay. Hypocalcin did not stimulate cyclic AMP production either in mouse calvaria or in cultured osteoblasts. In this respec
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31

Neale, Peta A., Cedric Feliers, Lisa Glauch, et al. "Application of in vitro bioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection." Environmental Science: Water Research & Technology 6, no. 9 (2020): 2444–53. http://dx.doi.org/10.1039/c9ew00987f.

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32

Nazir, Talha, Abdul Basit, Abdul Hanan, Muhammad Majeed, and Dewen Qiu. "In Vitro Pathogenicity of Some Entomopathogenic Fungal Strains against Green Peach Aphid Myzus persicae (Homoptera: Aphididae)." Agronomy 9, no. 1 (2018): 7. http://dx.doi.org/10.3390/agronomy9010007.

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Green peach aphid, Myzus persicae (Hemiptera: Aphididae), is an economically important pest of crops within more than 40 plant families all over the world. This study encompasses in-vitro pathogenicity of two strains of Beauveria bassiana (BB-72 and BB-252) and one strain of Lecanicillium lecanii (V-4) against green peach aphid (M. persicae). Using a leaf-dip method, three different bioassays were conducted comprised of filtrates and conidial concentrations of BB-72, BB-252 and V-4 fungal strains and their binary combinations. Infiltrate bioassays, 2 mL fungal filtrate of each strain was used.
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33

Kwon, Jung-Hwan, Thomas Wuethrich, Philipp Mayer, and Beate I. Escher. "Development of a dynamic delivery method for in vitro bioassays." Chemosphere 76, no. 1 (2009): 83–90. http://dx.doi.org/10.1016/j.chemosphere.2009.02.023.

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34

Kajjumba, George William, Matias Attene-Ramos, and Erica J. Marti. "Toxicity of lanthanide coagulants assessed using four in vitro bioassays." Science of The Total Environment 800 (December 2021): 149556. http://dx.doi.org/10.1016/j.scitotenv.2021.149556.

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35

Jenkins, PJ, TA Cross, LA Perry, SA Medbak, GM Besser, and AJ Clark. "The influence of plasma on basal and ACTH-stimulated in vitro adrenocortical steroidogenesis." Journal of Endocrinology 162, no. 1 (1999): 155–61. http://dx.doi.org/10.1677/joe.0.1620155.

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Early descriptions of in vitro ACTH bioassays all emphasised the need to use extracted plasma samples due to interference by an unidentified component. The aim of these studies was to elucidate the effects of whole plasma on ACTH steroidogenic activity in vitro and to identify the responsible factor. A sensitive in vitro dispersed bovine adrenocortical cell bioassay was established. The addition of 10% ACTH-depleted human pooled plasma to the incubation media resulted in basal steroidogenesis equivalent to that achieved with 10(-9) M ACTH1-24 and potentiated the steroidogenic activity of 10(-9
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Kim, S. H., K. Ichikawa, I. Koshiishi, and H. Utsumi. "Development of rapid in vitro assay for oxidative liver injury and its application to 230 chemicals." Water Science and Technology 46, no. 11-12 (2002): 337–41. http://dx.doi.org/10.2166/wst.2002.0759.

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Water environments are thought to be polluted with thousands of synthetic chemicals and biproducts involving persistent organic pollutants and endocrine disrupters, and their human and ecological impacts are causing serious anxiety. Many bioassays have been undertaken to evaluate the hazardous impacts of toxic chemicals dissolved in water. Reactive Oxygen Species (ROS) are well known to be involved in the toxicity of various chemicals. ROS are mostly generated in liver and cause oxidative damage to DNA, lipids and proteins, resulting in the failure of cellular functions. In order to develop an
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Kuo, Ching-Te, Siang-Rong Lu, Wei-Min Chen, et al. "Facilitating tumor spheroid-based bioassays and in vitro blood vessel modeling via bioinspired self-formation microstructure devices." Lab on a Chip 18, no. 16 (2018): 2453–65. http://dx.doi.org/10.1039/c8lc00423d.

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Generalova, Alla, Kristina Mironova, Natalya Sholina, et al. "Upconversion nanoparticles: on the way from diagnostics to theranostics." EPJ Web of Conferences 190 (2018): 03001. http://dx.doi.org/10.1051/epjconf/201819003001.

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We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue “transparency window”, as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility o
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39

Robacker, Carol D., and S. K. Braman. "In Vitro Screening of Azalea for Resistance to Azalea Lace Bug." HortScience 33, no. 3 (1998): 506b—506. http://dx.doi.org/10.21273/hortsci.33.3.506b.

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Azalea lace bug (Stephanitis pyrioides) is the most serious pest on azalea. Results of laboratory bioassays and field evaluations of 17 deciduous azalea taxa have identified three resistant taxa: R. canescens, R. periclymenoides, and R. prunifolium. Highly susceptible taxa are `Buttercup', `My Mary', R. oblongifolium, and the evergreen cultivar `Delaware Valley White'. To determine whether in vitro techniques would have potential value in screening or selecting for resistance, or for the identification of morphological or chemical factors related to resistance, an in-vitro screening assay was
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40

Kittinger, Clemens, Rita Baumert, Bettina Folli, et al. "Preliminary Toxicological Evaluation of the River Danube Using in Vitro Bioassays." Water 7, no. 12 (2015): 1959–68. http://dx.doi.org/10.3390/w7051959.

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41

Simoni, M., and E. Nieschlag. "In vitro bioassays of follicle-stimulating hormone: methods and clinical applications." Journal of Endocrinological Investigation 14, no. 11 (1991): 983–97. http://dx.doi.org/10.1007/bf03347131.

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42

Jia, Ai, Beate I. Escher, Frederic D. L. Leusch, et al. "In vitro bioassays to evaluate complex chemical mixtures in recycled water." Water Research 80 (September 2015): 1–11. http://dx.doi.org/10.1016/j.watres.2015.05.020.

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43

Santa Maria, A., A. Lopez, M. M. Diaz, et al. "Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro." Journal of Ethnopharmacology 57, no. 3 (1997): 183–87. http://dx.doi.org/10.1016/s0378-8741(97)00067-6.

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44

Cooper, Elliot, Kristine McGrath, and Alison Heather. "In Vitro Androgen Bioassays as a Detection Method for Designer Androgens." Sensors 13, no. 2 (2013): 2148–63. http://dx.doi.org/10.3390/s130202148.

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MARKIEWICZ, LESZEK, and ERLIO GURPIDE. "In Vitro Bioassays for Drugs with Dual Estrogenic and Progestagenic Activities." Annals of the New York Academy of Sciences 734, no. 1 The Human End (1994): 285–97. http://dx.doi.org/10.1111/j.1749-6632.1994.tb21758.x.

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46

Zhang, Yang, Jigang Wu, Wenping Xu, et al. "Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays." Environmental Pollution 220 (January 2017): 1127–37. http://dx.doi.org/10.1016/j.envpol.2016.11.022.

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47

Safe, S., D. Davis, M. Romkes, et al. "Development and validation of in vitro bioassays for 2,3,7,8-TCDD equivalents." Chemosphere 19, no. 1-6 (1989): 853–60. http://dx.doi.org/10.1016/0045-6535(89)90421-9.

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Lund, Rachel A., Elliot R. Cooper, Hui Wang, Zoe Ashley, Adam T. Cawley, and Alison K. Heather. "Nontargeted detection of designer androgens: Underestimated role of in vitro bioassays." Drug Testing and Analysis 13, no. 5 (2021): 894–902. http://dx.doi.org/10.1002/dta.3049.

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KUHN, KERSTIN, BERNHARD NOWAK, GÜNTER KLEIN, ANDREAS BEHNKE, ALBRECHT SEIDEL, and ALFONSO LAMPEN. "Determination of Polycyclic Aromatic Hydrocarbons in Smoked Pork by Effect-Directed Bioassay with Confirmation by Chemical Analysis." Journal of Food Protection 71, no. 5 (2008): 993–99. http://dx.doi.org/10.4315/0362-028x-71.5.993.

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Polycyclic aromatic hydrocarbons (PAHs) are generated during smoke curing and other heating treatments of food and represent a large class of chemical pollutants including a number of carcinogens. At present, PAHs are frequently detected by costly and time-consuming chemical analysis. Effect-directed in vitro cell–based bioassays of contaminants can offer a rapid, sensitive, and relatively inexpensive alternative for screening of contaminants in comparison to instrumental analysis. They enable estimation of total biological activity of all compounds acting through the same mode of binding. The
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Wide, Leif, and Bruce Hobson. "Influence of the assay method used on the selection of the most active forms of FSH from the human pituitary." Acta Endocrinologica 113, no. 1 (1986): 17–22. http://dx.doi.org/10.1530/acta.0.1130017.

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Abstract. The biological properties of different forms of human pituitary FSH, varying in their molecular charge, were investigated. FSH in two individual human pituitaries and a pool of 30 human pituitaries was extracted and subjected to electrophoresis. From each electrophoresis 14 consecutive fractions with the highest RIA activity were examined with in vitro and in vivo bioassays. The in vitro assay was based upon the estimation of oestradiol produced by cultured Sertoli cells from 10 day old rats. The in vivo bioassay was an hCG augmented test using immature female mice injected on 3 cons
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