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Journal articles on the topic 'Bioavailability – Research – Statistical methods'

Author: Grafiati

Published: 30 June 2021

Last updated: 29 July 2025

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1

Kondratenko, V. V., and E. Yu Agarkova. "Development of an approach to predicting the bioavailability of enteral nutrition products." Theory and practice of meat processing 9, no. 1 (2024): 15–23. http://dx.doi.org/10.21323/2414-438x-2024-9-1-15-23.

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One of the key factors while developing nutritional supplements is their bioavailability. To determine it, expensive and timeconsuming clinical studies of developed products are necessary. Using in silico methods may speed up and reduce the costs of such clinical studies. The purpose of this study is to develop an approach to predicting the integral bioavailability of enteral nutrition products (ENPs) based on a comprehensive analysis of the matrices of components and indicators. The includes a comprehensive empirical study based on a comparative statistical analysis of the matrix of studied E

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Selvaraj, Brito R., Seshaiah K. Sridhar, Bhaskar R. Kesavan, and Sucharitha Palagati. "Application of Statistical Tooling Techniques for Designing of Carvedilol Nanolipid Transferosomes and its Dermatopharmacokinetic and Pharmacodynamic Studies." Pharmaceutical Nanotechnology 8, no. 6 (2020): 452–70. http://dx.doi.org/10.2174/2211738508666200928164820.

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Background: The hypothesis is to augment the bioavailability and therapeutic potential of low bioavailable Carvedilol (25-35%) through Nanostructured Lipid Carrier (NLC) loaded Transdermal patch (Nanolipid Transferosomes). Methods: Box-Behnken design was designed to formulate NLC through a hot homogenization technique. About 17 formulations (C1-C17) were formulated by varying the critical material attribute and critical process parameter. Optimization was done based on its critical quality attributes like particle size, zeta potential and entrapment efficiency. Selected NLC (C16) has been fabr

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Zhang, Xuhuiqun, Amandeep Sandhu, Jiayi Fan, Di Xiao, Indika Edirisinghe, and Britt Burton-Freeman. "Metabolic Status and Gender Affect the Absorption and Metabolism of Red Raspberry (Poly)phenols." Current Developments in Nutrition 5, Supplement_2 (2021): 385. http://dx.doi.org/10.1093/cdn/nzab037_095.

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Abstract Objectives Red raspberries are rich in bioactive (poly)phenols, particularly anthocyanins and ellagitannins. A substantial amount of variability is observed in the bioavailability and metabolism of (poly)phenols in humans. This study aimed to investigate the potential factors, i.e., metabolic status, body mass index (BMI), age, gender and race, on (poly)phenol metabolism in individuals with different health statuses. Methods After 3-day wash-in and overnight fasting, subjects (n = 65, male: female 32:33, age 34 ± 1 years, BMI 27 ± 1 kg/m2, mean ± SEM) consumed 250 g red raspberries (2

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Urminská, Jana, Tomáš Tóth, Renáta Benda Prokeinová, and Peter Ondrišík. "The effect of the selected remediation medium on the cadmium bioavailability in the selected ecosystem in the Southwestern locality of Slovakia." Ekológia (Bratislava) 38, no. 3 (2019): 214–24. http://dx.doi.org/10.2478/eko-2019-0017.

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AbstractSoil is a sensitive ecological factor. Biodegradable materials from the environment can also be used to deal with serious ecological problems. Soil affecting by remediation medium - garden compost - was analysed for toxic cadmium (Cd) in terms of environmental protection. The objective of this research was to analyse soil and compost at foothill locality of the Tribeč Mountains (Southwestern Slovakia) in the years 2015−2017 to determine Cd contents in soil and compost, pH and to assess Cd bioavailability. The analyses were carried out using the Atomic Absorption Spectrometry with seven

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Morris, Claudia R., Frans Kuypers, Robert W. Hagar, et al. "Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results." Blood 116, no. 21 (2010): 1636. http://dx.doi.org/10.1182/blood.v116.21.1636.1636.

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Abstract Abstract 1636 Introduction: The erythrocyte redox environment may contribute to increased hemolysis and decreased nitric oxide (NO) bioavailability in pulmonary hypertension (PH) of sickle cell disease (SCD). Glutathione (GSH) is the principal thiol redox buffer in erythrocytes and its depletion has been linked to hemolysis. Glutamine plays an additional anti-oxidant role through preservation of the intracellular nicotinamide adenine dinucleotide (NAD) levels, required for reducing GSSG back to GSH. Altered GSH and glutamine metabolism will promote hemolysis and contribute to altered

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Hussaini, Azra, Anthony J. Olszanski, Cy Aaron Stein, Bill Bosch, and Paul Nemeth. "Relative bioavailability (BA) and bioequivalence (BE) study of abiraterone acetate (AA) fine particle (AAFP) with methylprednisolone (MP) and a reference formulation with prednisone (PN) in healthy male subjects." Journal of Clinical Oncology 35, no. 15_suppl (2017): e16538-e16538. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e16538.

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e16538 Background: AA is approved for treatment of metastatic castration-resistant prostate cancer when taken in combination with PN. The originator AA (OAA) formulation is poorly absorbed and exhibits large pharmacokinetic (PK) variability. AAFP is a proprietary formulation (utilizing SoluMatrix Fine-Particle Technology™) that was designed to provide improved BA. In a prior study in healthy subjects, AAFP 500 mg was established as bioequivalent to OAA 1000 mg when given in the fasted state. In this study, AAFP was evaluated in subjects in a fasted state with steady state (SS) MP, an alternati

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Adamiak-Giera, Urszula, Michał Gackowski, Damian Malinowski, et al. "Formulation Approaches for Optimizing Omeprazole Stability in Oral Liquid Dosage Forms." Pharmaceutics 17, no. 5 (2025): 594. https://doi.org/10.3390/pharmaceutics17050594.

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Background/Objectives: This study aimed to evaluate the degradation of omeprazole suspension under various pH conditions and to propose recommendations for preparing compounded suspensions. Given the clinical need for alternative dosage forms for pediatric and geriatric patients and those with dysphagia, the research focused on assessing whether modifications in formulation composition—specifically the inclusion of sodium bicarbonate—could improve omeprazole stability, thus enhancing its bioavailability. Methods: Three formulations were prepared: O1, based on crushed enteric-coated pellets fro

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Tzang, Bor-Show, Chih-Chen Tzang, Pei-Hua Chuang, et al. "Impact of Oseltamivir and Diabetes Development." Pharmaceuticals 18, no. 1 (2025): 128. https://doi.org/10.3390/ph18010128.

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Background/Objectives: Influenza is a major global health challenge, causing thousands of deaths annually. Antiviral drugs, particularly oseltamivir, a neuraminidase inhibitor, have become essential therapeutic options due to their oral bioavailability and efficacy. Previous studies suggest a potential association between oseltamivir use and the onset of diabetes mellitus. However, further investigation is needed to establish a definitive link. Methods: This retrospective cohort study utilized data from the Taiwan National Health Insurance Research Database (NHIRD), including 1,631,968 patient

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Martinez, Imanol, Kenneth Kernan, Piotr Piasecki, et al. "A novel abiraterone acetate oral suspension for patients with metastatic prostate cancer: An open-label, phase 3, randomized trial." Journal of Clinical Oncology 41, no. 16_suppl (2023): 5052. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.5052.

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5052 Background: Abiraterone acetate (AA) is a first-line oral hormone therapy for metastatic prostate cancer (mPC), but the licensed formulation is limited by large tablet size, requirement to take on an empty stomach, and pharmacokinetic variability. TAVT-45, a novel formulation of AA granules for oral suspension, offers improved oral bioavailability (allowing dose reduction), decreased food effect, and may provide an option for the ~20-30% of patients with dysphagia. This Phase 3, open-label global study (NCT04887506) aimed to establish therapeutic equivalence between TAVT-45 granules and r

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Dhillon, N., B. B. Aggarwal, R. A. Newman, et al. "Curcumin and pancreatic cancer: Phase II clinical trial experience." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4599. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4599.

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4599 Background: Pancreatic cancer is virtually always lethal, and the only FDA-approved therapies–gemcitabine and erlotinib–produce objective responses in less than 10% of patients. Curcumin (diferuloyl methane) is a plant-derived dietary ingredient that suppresses NF-κB and numerous other pathways relevant to pancreatic cancer and has potent preclinical anti-tumor activity. Herein, we evaluated the safety and potential antitumor activity of curcumin against advanced pancreatic cancer, and its impact on biologic correlates. Methods: Patients received 8 grams of curcumin by mouth daily for two

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Lalani, Aly-Khan A., Rana R. McKay, Xun Lin, Ronit Simantov, Marina D. Kaymakcalan, and Toni K. Choueiri. "Proton pump inhibitors (PPIs) and survival outcomes in patients with metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 35, no. 6_suppl (2017): 493. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.493.

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493 Background: PPIs are potent inhibitors of gastric acid secretion and can affect the bioavailability of orally administered cancer targeting therapies, such as vascular endothelial growth factor tyrosine-kinase inhibitors (VEGF-TKIs). Smaller preclinical and clinical studies have attempted to assess the interaction between VEGF-TKIs and PPIs in patients with advanced cancers; however, these studies are limited and larger analyses from rigorous datasets have been lacking. We investigate the impact of PPI use on survival in patients with mRCC treated with oral VEGF-TKIs. Methods: A pooled ana

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Awari, Monika* Dr. Tambe Sagar. "Dissolution Profile Evaluation of Anastrozole Tablets: A Review for Biowaiver Consideration." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2474–82. https://doi.org/10.5281/zenodo.15425793.

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Anastrozole, a non-steroidal aromatase inhibitor, is widely used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. The efficacy of Anastrozole is significantly influenced by its dissolution profile, which affects the drug's bioavailability and therapeutic outcomes. This review aims to evaluate the dissolution profiles of Anastrozole tablets and discuss the implications for biowaiver considerations. We summarize the formulation characteristics of Anastrozole tablets, including their composition and manufacturing processes, and highlight the importance of disso

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Firmansyah, Aryan, Syifana Yashuda, Hening Hasyyati Husna Pekerti, Jasmine Aprilia Nur Zharifah, Eva Agustin Nurhadiyanti, and Rista Fauziningtyas. "Effectiveness of Turmeric Rhizome Extract and Egg Shell Waste Ointment in Healing Diabetic Wounds in Mice With DDY Strain." Critical Medical and Surgical Nursing Journal 14, no. 1 (2025): 19–27. https://doi.org/10.20473/cmsnj.v14i1.61095.

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Introduction: One of the complications of diabetes is wounds on the feet. The use of curcumin as a natural ingredient can accelerate the healing of diabetic wounds with its anti-inflammatory and antioxidant properties. However, curcumin has low solubility so it requires a conductor such as hyaluronic acid in egg shells to increase hydration and bioavailability. The aim of this research was to determine the effectiveness of turmeric rhizome and egg shell extract ointment in healing diabetic wounds. Methods: True experimental research was carried out using a pre-post test control group design. T

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Umanzor Funez, Gerardo Antonio, Hope S. Rugo, Jorge Umanzor, et al. "Confirmed tumor response by molecular subtype in patients with metastatic breast cancer: Sub-analysis from a phase 3 clinical study comparing oral paclitaxel and encequidar to IV paclitaxel." Journal of Clinical Oncology 39, no. 15_suppl (2021): 1073. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1073.

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1073 Background: Paclitaxel, a foundation treatment in MBC, is hydrophobic and must be formulated for IV administration with Cremophor EL, increasing the risk of infusion reactions and necessitating pre-treatment with corticosteroids and antihistamines. Paclitaxel cannot be administered orally because it is a substrate for P-gp. The oral bioavailability of paclitaxel is improved when administered 1 hour after the highly selective, potent, and minimally absorbed P-gp inhibitor encequidar. As oral paclitaxel is Cremophor-free there is no need for pretreatment for infusion reactions. While target

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Ogudov, Aleksandr Stepanovich, Olga Anatolievna Shepeleva, Natalya Fedorovna Chuenko, Nikita Alexandrovich Shestakov, Irina Gennadyevna Shevkun, and Irina Igorevna Novikova. "Evaluation of the biological effect of the brown algae Laminaria digitata (based on studies on experimental animals)." Science for Education Today 12, no. 6 (2022): 189–211. http://dx.doi.org/10.15293/2658-6762.2206.08.

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Introduction. Currently, the problem of keeping schoolchildren healthy is acute. One of the leading risk factors for the health of schoolchildren is nutrition, in the organization of which much attention has recently been paid to the inclusion of special foods that help prevent diet-related diseases. The White Sea brown alga, Laminaria digitata, has been shown to be a natural source of bioactive compounds. However, the mechanisms of the kinetics of health-promoting effects during long-term dietary intake of Laminaria digitata are poorly studied which makes it difficult to solve practical probl

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Nurkistin, Dika, Didik Gunawan Tamtomo, and Budiyanti Wiboworini. "Hypolipidemic Effects of Modified Edamame Tempeh Flour on Lipid Profile Levels in Dyslipidemia Rats." Amerta Nutrition 6, no. 4 (2022): 422–31. http://dx.doi.org/10.20473/amnt.v7i4.2022.422-431.

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Background: Dyslipidemia is a lipid metabolism disorder that causes an increase or decrease in plasma lipid concentrations. Comprehensive management is an attempt to prevent and reduce dyslipidemia, one of which is nutritional therapy. Edamame contains nutrients such as protein, fat, fiber, and isoflavones that have the potential to improve lipid profiles. Edamame tempeh production is one way to improve product quality that is improving nutritional quality, digestibility, and bioavailability. Edamame tempeh modification is conducted by adding yeast Saccharomyces cerevisiae. This yeast plays a

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Seragel-Deen, Fatma, Seham A. Abdel Ghani, Houry M. Baghdadi, and Ali M. Saafan. "Combined Cisplatin Treatment and Photobiomodulation at High Fluence Induces Cytochrome c Release and Cytomorphologic Alterations in HEp-2 Cells." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 366–73. http://dx.doi.org/10.3889/oamjms.2020.4561.

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BACKGROUND: Photochemotherapy is thought to be a novel therapeutic modality for cancer. The photobiomodulation (PBM), applied through high fluence low-level laser irradiation (HF-LLLI), can be combined with the chemotherapeutic drug cisplatin to gain the benefit of potentiating its cytotoxic effect at possibly lower doses. AIM: The study aimed at investigation of the apoptotic effect of PBM, through LLLI (at HF), alone and in combination with cisplatin on cultured laryngeal cancer (HEp-2) cells. MATERIALS AND METHODS: In the current experimental in vitro research, cultured laryngea

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Yakubova, E. G. "Features of achieving compensation of hypothyroisis in pregnant women." Clinical and experimental thyroidology 19, no. 1 (2023): 29–34. http://dx.doi.org/10.14341/ket12743.

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BACKGROUND: Hypofunction of the thyroid gland in women at the pre-pregnancy stage and during pregnancy is associated with a high risk of congenital hypothyroidism in children, as a result of which irreversible changes in the nervous system are formed. Despite the mandatory intake of potassium iodide preparations, pregnant women often develop gestational hypothyroidism, which requires the appointment of levothyroxine. Many women have episodic hypofunction of the thyroid gland before pregnancy, associated with various factors. Diagnosed hypothyroidism requires hormonal correction. The recommende

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Dzugkoev, S. G., F. S. Dzugkoeva, O. I. Margieva, A. E. Khubulova, and I. V. Mozhaeva. "EXPERIMENTAL PARTICIPATION OF PHARMACOLOGICAL SUBSTANCES IN MECHANISMS OF LEAD ACETATE TOXICITY." Pharmacy & Pharmacology 10, no. 6 (2023): 589–600. http://dx.doi.org/10.19163/2307-9266-2022-10-6-589-600.

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The aim of the work is to study pharmacological substances that play a role of eNOS expression regulators in the modification of lead intoxication effects in the experiment.Materials and methods. In the experiment, linear male rats of the same age were used: intact and with lead intoxication (120 heads). The study design was the following: group 1 – control; group 2 – intoxication with a lead acetate solution; group 3 – intact + L-nitroarginine methyl ester; group 4 – lead acetate + L-nitroarginine methyl ester; group 5 – intact + L-arginine; group 6 – lead acetate + L-arginine. The research c

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Mehbatool, Hira Iftikhar, Anjum Raza, et al. "Investigating the Influence of Spinach Sauce in Modulating Serum Calcium in Osteoporotic Females." Journal of Health and Rehabilitation Research 4, no. 2 (2024): 719–24. http://dx.doi.org/10.61919/jhrr.v4i2.878.

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Background: The modulation of serum calcium levels through diet is a critical aspect of managing osteoporosis, particularly in postmenopausal women. Spinach, known for its high calcium content, offers potential benefits for bone health due to its rich nutrient profile. This study aimed to develop a spinach sauce, evaluate its consumer acceptability, and investigate its impact on serum calcium levels in osteoporotic females. Objective: To develop a nutritionally rich spinach sauce, assess its sensory acceptability, and evaluate its effectiveness in modulating serum calcium levels among osteopor

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Maslii, Yu.S., B.A. Adler, and O.A. Ruban. "Development of hard candy lozenges composition to promote smoking cessation." Annals of Mechnikov Institute, no. 1 (March 13, 2022): 63–69. https://doi.org/10.5281/zenodo.6350221.

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<strong>Introduction. </strong>Smoking is a complex medical and social problem not only in Ukraine but also around the world, taking into account high prevalence of this bad habit and its negative impact on human health. Tobacco dependence contributes to the emergence and progression of cardiovascular, gastrointestinal and dermatological diseases, adversely affects the psycho-emotional and sexual spheres, increases the risk of cancer and is the most important cause of chronic lung disease. Smoking is characterized by rapid addiction and long-term, and often chronic, addiction (nicotinism). Tod

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Cody, Rebecca L., and Marion K. Slack. "Crossover Design in Pharmacy Research." Annals of Pharmacotherapy 26, no. 3 (1992): 327–33. http://dx.doi.org/10.1177/106002809202600303.

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OBJECTIVE: Reports of pharmacy research using crossover designs were reviewed to determine if the studies adequately consider interaction effects and use appropriate statistical analyses. DATA SOURCES: All crossover studies published in DICP, The Annals of Pharmacotherapy during 1988 and 1989 were analyzed. STUDY SELECTION: Reports of crossover studies were included only if at least two treatments were applied in a different order to two or more groups of subjects. DATA EXTRACTION: The principal characteristics of crossover studies and the critical design variables were listed and each study a

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Bumbăcilă, Bogdan, and Mihai V. Putz. "Neurotoxicity of Pesticides: The Roadmap for the Cubic Mode of Action." Current Medicinal Chemistry 27, no. 1 (2020): 54–77. http://dx.doi.org/10.2174/0929867326666190704142354.

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Pesticides are used today on a planetary-wide scale. The rising need for substances with this biological activity due to an increasing consumption of agricultural and animal products and to the development of urban areas makes the chemical industry to constantly investigate new molecules or to improve the physicochemical characteristics, increase the biological activities and improve the toxicity profiles of the already known ones. Molecular databases are increasingly accessible for in vitro and in vivo bioavailability studies. In this context, structure-activity studies, by their in silico -

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Mimica, Bruna, Viljemka Bučević Popović, Ines Banjari, Antonia Jeličić Kadić, and Livia Puljak. "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials: A Meta-Research Study." Pharmaceuticals 15, no. 8 (2022): 939. http://dx.doi.org/10.3390/ph15080939.

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It is unknown how randomized controlled trials (RCTs) approach the problem related to curcumin bioavailability. We analyzed methods and reporting regarding the bioavailability of systemic oral curcumin used in RCTs. We searched PubMed on 12 September 2020, to find articles reporting RCTs that used curcumin as an intervention. We extracted data about trial characteristics, curcumin products used, methods for improving curcumin bioavailability, and mentions of curcumin bioavailability. We included 165 RCTs. The most common category of intervention was simply described as “curcumin” or “curcumino

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Bučević Popović, Viljemka, Esma Karahmet Farhat, Ines Banjari, Antonia Jeličić Kadić, and Livia Puljak. "Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study." Pharmaceuticals 17, no. 2 (2024): 164. http://dx.doi.org/10.3390/ph17020164.

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Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits its therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered the bioavailability of systemic oral curcumin formulations when synthesizing evidence from human clinical trials. A total of 171 systematic reviews published between 2003 and 2022 were included in the study. From the included studies, we extracted data on study

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Greenberg, E. R., Ta Stukel, J. A. Baron, and D. H. Freeman. "Statistical methods in research." Lancet 342, no. 8878 (1993): 1055. http://dx.doi.org/10.1016/0140-6736(93)92911-c.

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27

Chan, Wenyaw. "Statistical Methods in Medical Research." Model Assisted Statistics and Applications 8, no. 2 (2013): 83–84. http://dx.doi.org/10.3233/mas-130255.

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28

Gibbons, Robert R., Donald R. Hedeker, and Alexander von Eye. "Statistical Methods in Longitudinal Research:." Journal of the American Statistical Association 86, no. 416 (1991): 1146. http://dx.doi.org/10.2307/2290546.

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Armitage, P., and G. Berry. "Statistical Methods in Medical Research." Biometrics 53, no. 1 (1997): 391. http://dx.doi.org/10.2307/2533132.

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30

Satagopan, Jaya M., and Alex D. Smith. "Statistical Methods in Genomics Research." Heart Drug 3, no. 1 (2003): 48–60. http://dx.doi.org/10.1159/000070907.

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31

Wickham, Carol A. C., P. Armitage, and G. Berry. "Statistical Methods in Medical Research." Journal of the Royal Statistical Society. Series A (Statistics in Society) 151, no. 2 (1988): 361. http://dx.doi.org/10.2307/2982765.

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32

Simpson, Pippa M., John A. Spratt, and John S. Spratt. "Statistical methods in cancer research." Journal of Surgical Oncology 76, no. 3 (2001): 201–23. http://dx.doi.org/10.1002/jso.1035.

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Gardner, Bernard. "Statistical methods in cancer research." Journal of Surgical Oncology 78, no. 4 (2001): 281. http://dx.doi.org/10.1002/jso.1170.

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Hande, K. R., M. G. Krozely, F. A. Greco, J. D. Hainsworth, and D. H. Johnson. "Bioavailability of low-dose oral etoposide." Journal of Clinical Oncology 11, no. 2 (1993): 374–77. http://dx.doi.org/10.1200/jco.1993.11.2.374.

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PURPOSE To determine the bioavailability of oral etoposide capsules administered at doses of 100 mg and 400 mg. PATIENTS AND METHODS The bioavailability of oral etoposide was determined by measuring the area under the etoposide plasma concentration versus time curve (AUC) following intravenous (IV) etoposide administration and comparing that value to the AUC achieved following an oral dose administered 1 day later to the same patient. The bioavailability of a 100-mg oral dose of etoposide was measured on 16 occasions in 11 patients. The bioavailability of a 400-mg dose was determined on 12 occ

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35

Detterich, Jon, Adam Bush, Roberta Miyeko Kato, et al. "Elevated Tricuspid Regurgitation Jet Correlates with Decreased Brachial Artery Relaxivity In Sickle Cell Anemia Patients on Chronic Transfusion Therapy." Blood 116, no. 21 (2010): 1645. http://dx.doi.org/10.1182/blood.v116.21.1645.1645.

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Abstract Abstract 1645 Introduction: Vascular disease in both pulmonary and systemic vessels underlies most complications of sickle cell anemia (SCA). Multiple mechanisms contribute to this process, including inflammation, oxidative stress and decreased nitric oxide bioavailability. Chronic transfusion therapy (CTT) is thought to ameliorate some of these factors. Our goal was to determine the relationship between systemic vascular function, as indexed by flow mediated dilation (FMD), and elevated tricuspid regurgitation jet (TRJ) as a surrogate for pulmonary hypertension (PH), in chronically t

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Rehman, Saleha, Bushra Nabi, Mohammad Fazil, et al. "Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir." BioMed Research International 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/8274927.

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Objective. The aim of the present study was to improve bioavailability of an important antiretroviral drug, Darunavir (DRV), which has low water solubility and poor intestinal absorption through solid dispersion (SD) approach incorporating polymer with P-glycoprotein inhibitory potential. Methods. A statistical approach where design of experiment (DoE) was used to prepare SD of DRV with incorporation of P-glycoprotein inhibitors. Using DoE, different methods of preparation, like melt, solvent evaporation, and spray drying method, utilizing carriers like Kolliphor TPGS and Soluplus were evaluat

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Asif, Afzal Haq, Prasanna Kumar Desu, Rajasekhar Reddy Alavala, Gudhanti Siva Naga Koteswara Rao, Nagaraja Sreeharsha, and Girish Meravanige. "Development, Statistical Optimization and Characterization of Fluvastatin Loaded Solid Lipid Nanoparticles: A 32 Factorial Design Approach." Pharmaceutics 14, no. 3 (2022): 584. http://dx.doi.org/10.3390/pharmaceutics14030584.

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The purpose of the present research work was to design, optimize, and evaluate fluvastatin-loaded solid lipid nanoparticles (FLV-SLNPs) using 32 factorial design for enhancing the bioavailability. Fluvastatin has several disadvantages, including the low solubility and substantial first-pass metabolism resulting in a low (30%) bioavailability and a short elimination half-life. FLV-SLNPs were prepared using the nano-emulsion technique. For the optimization of the FLV-SLNPs, a total of nine formulations were prepared by varying two independent factors at three levels, using full factorial design.

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Newgard, Craig D., and Roger J. Lewis. "Statistical Methods for Prehospital Care Research." Prehospital Emergency Care 6, sup2 (2002): S9—S17. http://dx.doi.org/10.3109/10903120209102676.

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Bourke, P. D. "Statistical Methods in Research and Production." Irish Mathematical Society Bulletin 0015 (1985): 75–78. http://dx.doi.org/10.33232/bims.0015.75.78.

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Wegner, Gail D. "Statistical Methods for Health Care Research." Journal of Gerontological Nursing 21, no. 7 (1995): 52. http://dx.doi.org/10.3928/0098-9134-19950701-15.

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Marzjarani, Morteza. "Statistical Methods in Social Science Research." Technometrics 62, no. 2 (2020): 1–288. http://dx.doi.org/10.1080/00401706.2020.1744914.

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Sanchis, Juan, Pablo Avanzas, Antoni Bayes-Genis, Leopoldo Pérez de Isla, and Magda Heras. "New Statistical Methods in Cardiovascular Research." Revista Española de Cardiología (English Edition) 64, no. 6 (2011): 499–500. http://dx.doi.org/10.1016/j.rec.2011.01.016.

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Hagan, Paul, and Dymphna Fellowes. "Multivariate statistical methods in battery research." Journal of Power Sources 122, no. 1 (2003): 77–84. http://dx.doi.org/10.1016/s0378-7753(03)00344-6.

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Lovell, David. "Statistical methods for pharmaceutical research planning." Food and Chemical Toxicology 25, no. 11 (1987): 879. http://dx.doi.org/10.1016/0278-6915(87)90272-9.

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Akimova, O. V., and N. V. Zakharchenko. "THE STATISTICAL METHODS IN PEDAGOGICAL RESEARCH." Innovate Pedagogy 1, no. 20 (2020): 68–71. http://dx.doi.org/10.32843/2663-6085-2020-20-1-14.

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Johnson, Marsha. "Statistical Methods for Health Care Research." Gastroenterology Nursing 19, no. 4 (1996): 153. http://dx.doi.org/10.1097/00001610-199607000-00010.

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Schinka, John A., Leif LaLone, and Jo Ann Broeckel. "Statistical Methods in Personality Assessment Research." Journal of Personality Assessment 68, no. 3 (1997): 487–96. http://dx.doi.org/10.1207/s15327752jpa6803_2.

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Schober, Patrick, and Thomas R. Vetter. "Nonparametric Statistical Methods in Medical Research." Anesthesia & Analgesia 131, no. 6 (2020): 1862–63. http://dx.doi.org/10.1213/ane.0000000000005101.

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Morozkina, E. A., V. V. Vorobyev, and Z. M. Safina. "Statistical research methods in literary translation." Доклады Башкирского университета 8, no. 3 (2023): 130–37. http://dx.doi.org/10.33184/dokbsu-2023.3.15.

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Stielow, Marlena, Adrianna Witczyńska, Natalia Kubryń, Łukasz Fijałkowski, Jacek Nowaczyk, and Alicja Nowaczyk. "The Bioavailability of Drugs—The Current State of Knowledge." Molecules 28, no. 24 (2023): 8038. http://dx.doi.org/10.3390/molecules28248038.

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Abstract:

Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients’ bodies is essential to ensure proper and safe treatment. This publication aims to highlight the relevance of drug bioavailability research and its importance in therapy. In addition to biochemical activity, bioavailability also plays a critical role in achieving the desired therapeutic effects. This may seem obvious, but it is worth noting that a drug can only produce the expected effect if the proper

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