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Journal articles on the topic 'Bioavailability – Research – Statistical methods'

Author: Grafiati

Published: 30 June 2021

Last updated: 6 February 2022

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1

Kruijtzer, C. M. F., J. H. Beijnen, H. Rosing, et al. "Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918." Journal of Clinical Oncology 20, no. 13 (2002): 2943–50. http://dx.doi.org/10.1200/jco.2002.12.116.

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PURPOSE: We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate–binding cassette drug transporter, substantially limits the oral bioavailability of topotecan in mdr1a/1b(−/−) P-glycoprotein (P-gp) knockout and wild-type mice. GF120918 is a potent inhibitor of BCRP and P-gp. The aim was to increase the bioavailability of topotecan by GF120918. PATIENTS AND METHODS: In cohort A, eight patients received 1.0 mg/m2 oral topotecan with or without coadministration of one single oral dose of 1,000 mg GF120918 (day 1 or day 8). In cohort B, eight other

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2

van Leeuwen, Roelof W. F., Robert Peric, Koen G. A. M. Hussaarts, et al. "Influence of the Acidic Beverage Cola on the Absorption of Erlotinib in Patients With Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 34, no. 12 (2016): 1309–14. http://dx.doi.org/10.1200/jco.2015.65.2560.

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Purpose Erlotinib depends on stomach pH for its bioavailability. When erlotinib is taken concurrently with a proton pump inhibitor (PPI), stomach pH increases, which results in a clinically relevant decrease of erlotinib bioavailability. We hypothesized that this drug-drug interaction is reversed by taking erlotinib with the acidic beverage cola. The effects of cola on erlotinib bioavailability in patients not treated with a PPI were also studied. Patients and Methods In this randomized, cross-over, pharmacokinetic study in patients with non–small-cell lung cancer, we studied intrapatient diff

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Selvaraj, Brito R., Seshaiah K. Sridhar, Bhaskar R. Kesavan, and Sucharitha Palagati. "Application of Statistical Tooling Techniques for Designing of Carvedilol Nanolipid Transferosomes and its Dermatopharmacokinetic and Pharmacodynamic Studies." Pharmaceutical Nanotechnology 8, no. 6 (2020): 452–70. http://dx.doi.org/10.2174/2211738508666200928164820.

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Background: The hypothesis is to augment the bioavailability and therapeutic potential of low bioavailable Carvedilol (25-35%) through Nanostructured Lipid Carrier (NLC) loaded Transdermal patch (Nanolipid Transferosomes). Methods: Box-Behnken design was designed to formulate NLC through a hot homogenization technique. About 17 formulations (C1-C17) were formulated by varying the critical material attribute and critical process parameter. Optimization was done based on its critical quality attributes like particle size, zeta potential and entrapment efficiency. Selected NLC (C16) has been fabr

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Urminská, Jana, Tomáš Tóth, Renáta Benda Prokeinová, and Peter Ondrišík. "The effect of the selected remediation medium on the cadmium bioavailability in the selected ecosystem in the Southwestern locality of Slovakia." Ekológia (Bratislava) 38, no. 3 (2019): 214–24. http://dx.doi.org/10.2478/eko-2019-0017.

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AbstractSoil is a sensitive ecological factor. Biodegradable materials from the environment can also be used to deal with serious ecological problems. Soil affecting by remediation medium - garden compost - was analysed for toxic cadmium (Cd) in terms of environmental protection. The objective of this research was to analyse soil and compost at foothill locality of the Tribeč Mountains (Southwestern Slovakia) in the years 2015−2017 to determine Cd contents in soil and compost, pH and to assess Cd bioavailability. The analyses were carried out using the Atomic Absorption Spectrometry with seven

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5

Zhang, Xuhuiqun, Amandeep Sandhu, Jiayi Fan, Di Xiao, Indika Edirisinghe, and Britt Burton-Freeman. "Metabolic Status and Gender Affect the Absorption and Metabolism of Red Raspberry (Poly)phenols." Current Developments in Nutrition 5, Supplement_2 (2021): 385. http://dx.doi.org/10.1093/cdn/nzab037_095.

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Abstract Objectives Red raspberries are rich in bioactive (poly)phenols, particularly anthocyanins and ellagitannins. A substantial amount of variability is observed in the bioavailability and metabolism of (poly)phenols in humans. This study aimed to investigate the potential factors, i.e., metabolic status, body mass index (BMI), age, gender and race, on (poly)phenol metabolism in individuals with different health statuses. Methods After 3-day wash-in and overnight fasting, subjects (n = 65, male: female 32:33, age 34 ± 1 years, BMI 27 ± 1 kg/m2, mean ± SEM) consumed 250 g red raspberries (2

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6

Hussaini, Azra, Anthony J. Olszanski, Cy Aaron Stein, Bill Bosch, and Paul Nemeth. "Relative bioavailability (BA) and bioequivalence (BE) study of abiraterone acetate (AA) fine particle (AAFP) with methylprednisolone (MP) and a reference formulation with prednisone (PN) in healthy male subjects." Journal of Clinical Oncology 35, no. 15_suppl (2017): e16538-e16538. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e16538.

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e16538 Background: AA is approved for treatment of metastatic castration-resistant prostate cancer when taken in combination with PN. The originator AA (OAA) formulation is poorly absorbed and exhibits large pharmacokinetic (PK) variability. AAFP is a proprietary formulation (utilizing SoluMatrix Fine-Particle Technology™) that was designed to provide improved BA. In a prior study in healthy subjects, AAFP 500 mg was established as bioequivalent to OAA 1000 mg when given in the fasted state. In this study, AAFP was evaluated in subjects in a fasted state with steady state (SS) MP, an alternati

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7

Morris, Claudia R., Frans Kuypers, Robert W. Hagar, et al. "Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results." Blood 116, no. 21 (2010): 1636. http://dx.doi.org/10.1182/blood.v116.21.1636.1636.

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Abstract Abstract 1636 Introduction: The erythrocyte redox environment may contribute to increased hemolysis and decreased nitric oxide (NO) bioavailability in pulmonary hypertension (PH) of sickle cell disease (SCD). Glutathione (GSH) is the principal thiol redox buffer in erythrocytes and its depletion has been linked to hemolysis. Glutamine plays an additional anti-oxidant role through preservation of the intracellular nicotinamide adenine dinucleotide (NAD) levels, required for reducing GSSG back to GSH. Altered GSH and glutamine metabolism will promote hemolysis and contribute to altered

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8

Dhillon, N., B. B. Aggarwal, R. A. Newman, et al. "Curcumin and pancreatic cancer: Phase II clinical trial experience." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4599. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4599.

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4599 Background: Pancreatic cancer is virtually always lethal, and the only FDA-approved therapies–gemcitabine and erlotinib–produce objective responses in less than 10% of patients. Curcumin (diferuloyl methane) is a plant-derived dietary ingredient that suppresses NF-κB and numerous other pathways relevant to pancreatic cancer and has potent preclinical anti-tumor activity. Herein, we evaluated the safety and potential antitumor activity of curcumin against advanced pancreatic cancer, and its impact on biologic correlates. Methods: Patients received 8 grams of curcumin by mouth daily for two

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9

Lalani, Aly-Khan A., Rana R. McKay, Xun Lin, Ronit Simantov, Marina D. Kaymakcalan, and Toni K. Choueiri. "Proton pump inhibitors (PPIs) and survival outcomes in patients with metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 35, no. 6_suppl (2017): 493. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.493.

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493 Background: PPIs are potent inhibitors of gastric acid secretion and can affect the bioavailability of orally administered cancer targeting therapies, such as vascular endothelial growth factor tyrosine-kinase inhibitors (VEGF-TKIs). Smaller preclinical and clinical studies have attempted to assess the interaction between VEGF-TKIs and PPIs in patients with advanced cancers; however, these studies are limited and larger analyses from rigorous datasets have been lacking. We investigate the impact of PPI use on survival in patients with mRCC treated with oral VEGF-TKIs. Methods: A pooled ana

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10

Nagler, Arnon, Vanderson Rocha, Myriam Labopin, et al. "Allogeneic Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia in Remission: Comparison of Intravenous Busulfan Plus Cyclophosphamide (Cy) Versus Total-Body Irradiation Plus Cy As Conditioning Regimen—A Report From the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation." Journal of Clinical Oncology 31, no. 28 (2013): 3549–56. http://dx.doi.org/10.1200/jco.2013.48.8114.

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Purpose Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu. Patients and Methods We performed a retrospective registry-based study comparing outcomes

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11

Umanzor Funez, Gerardo Antonio, Hope S. Rugo, Jorge Umanzor, et al. "Confirmed tumor response by molecular subtype in patients with metastatic breast cancer: Sub-analysis from a phase 3 clinical study comparing oral paclitaxel and encequidar to IV paclitaxel." Journal of Clinical Oncology 39, no. 15_suppl (2021): 1073. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1073.

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1073 Background: Paclitaxel, a foundation treatment in MBC, is hydrophobic and must be formulated for IV administration with Cremophor EL, increasing the risk of infusion reactions and necessitating pre-treatment with corticosteroids and antihistamines. Paclitaxel cannot be administered orally because it is a substrate for P-gp. The oral bioavailability of paclitaxel is improved when administered 1 hour after the highly selective, potent, and minimally absorbed P-gp inhibitor encequidar. As oral paclitaxel is Cremophor-free there is no need for pretreatment for infusion reactions. While target

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12

Hsu, CS, W.-H. Hao, J.-J. Wang, T.-H. Lin, and R.-Y. Kuo. "Antitumor efficacy and pharmacokinetics of a novel gemcitabine oral formulation (INNO-D07001) in xenograft animal models." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14699-e14699. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14699.

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e14699 Background: INNO-D07001 is a novel oral gemcitabine formulation which was developed to enhance the oral bioavailability of gemcitabine and it has been successfully demonstrated in both beagle dogs as well as nude mice. The objectives of this study were to examine the antitumor activity of this novel gemcitabine oral formulation in human xenograft models of pancreatic tumors with different daily doses as well as various dosing schedules. Methods: The INNO-D07001 dosing solutions (gemcitabine oral formulation) were formulated freshly before treatment and water for injection (USP) was used

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13

Kumar, Inder, Dipima Chaudhary, Bhumika Thakur, and Vinay Pandit. "Formulation and Evaluation of Piroxicam Fast Dissolving Tablets Using Direct Compression and Sublimation Method." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 17–25. http://dx.doi.org/10.22270/jddt.v10i3-s.4063.

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Objective: In the present research work, fast dissolving tablets of Piroxicam were formulated by two different techniques i.e. direct compression method and sublimation method using different superdisintegrants. Methods: Twelve formulations were prepared (PXM1 to PXM12) in which first six formulation were prepared by direct compression technique and other six formulation were prepared by sublimation method by using camphor as a sublimating agent. Result and Discussion: All the formulations were subjected for precompression, post compression parameters, and shows all the data within

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14

Greenberg, E. R., Ta Stukel, J. A. Baron, and D. H. Freeman. "Statistical methods in research." Lancet 342, no. 8878 (1993): 1055. http://dx.doi.org/10.1016/0140-6736(93)92911-c.

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15

Cody, Rebecca L., and Marion K. Slack. "Crossover Design in Pharmacy Research." Annals of Pharmacotherapy 26, no. 3 (1992): 327–33. http://dx.doi.org/10.1177/106002809202600303.

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OBJECTIVE: Reports of pharmacy research using crossover designs were reviewed to determine if the studies adequately consider interaction effects and use appropriate statistical analyses. DATA SOURCES: All crossover studies published in DICP, The Annals of Pharmacotherapy during 1988 and 1989 were analyzed. STUDY SELECTION: Reports of crossover studies were included only if at least two treatments were applied in a different order to two or more groups of subjects. DATA EXTRACTION: The principal characteristics of crossover studies and the critical design variables were listed and each study a

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16

Trang, Michael, Justin C. Bader, Eric A. Ople, et al. "1340. Population Pharmacokinetic (PK) Analysis of APX001 Using Phase 1 Data." Open Forum Infectious Diseases 5, suppl_1 (2018): S409—S410. http://dx.doi.org/10.1093/ofid/ofy210.1172.

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Abstract Background APX001 is a novel antifungal agent which is rapidly converted to the active metabolite APX001A. APX001A exhibits in vitro activity against many clinically important yeast and fungi, including echinocandin- and azole-resistant Candida species. Given this activity, intravenous (IV) and oral (PO) formulations of APX001 are being developed for the treatment of patients with candidemia or invasive candidiasis. Phase 1 data were used to develop a population PK (PPK) model to describe the time-course of APX001A in plasma. Methods The PPK model was developed using 3,736 plasma PK s

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17

Miller, A. A., J. E. Herndon, D. R. Hollis, et al. "Schedule dependency of 21-day oral versus 3-day intravenous etoposide in combination with intravenous cisplatin in extensive-stage small-cell lung cancer: a randomized phase III study of the Cancer and Leukemia Group B." Journal of Clinical Oncology 13, no. 8 (1995): 1871–79. http://dx.doi.org/10.1200/jco.1995.13.8.1871.

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PURPOSE This was a randomized phase III study to test the schedule dependency of etoposide given as a conventional 3-day intravenous (IV) regimen versus a prolonged 21-day oral regimen for extensive-stage small-cell lung cancer (SCLC). Both regimens contained IV cisplatin. The objectives were to compare survival (primary end point) and to establish response rates, failure-free survival, and toxicity (secondary end points). PATIENTS AND METHODS Patients with untreated measurable or assessable disease and normal organ function were eligible. Randomization was stratified according to performance

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18

Seragel-Deen, Fatma, Seham A. Abdel Ghani, Houry M. Baghdadi, and Ali M. Saafan. "Combined Cisplatin Treatment and Photobiomodulation at High Fluence Induces Cytochrome c Release and Cytomorphologic Alterations in HEp-2 Cells." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 366–73. http://dx.doi.org/10.3889/oamjms.2020.4561.

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BACKGROUND: Photochemotherapy is thought to be a novel therapeutic modality for cancer. The photobiomodulation (PBM), applied through high fluence low-level laser irradiation (HF-LLLI), can be combined with the chemotherapeutic drug cisplatin to gain the benefit of potentiating its cytotoxic effect at possibly lower doses. AIM: The study aimed at investigation of the apoptotic effect of PBM, through LLLI (at HF), alone and in combination with cisplatin on cultured laryngeal cancer (HEp-2) cells. MATERIALS AND METHODS: In the current experimental in vitro research, cultured laryngea

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19

Chan, Wenyaw. "Statistical Methods in Medical Research." Model Assisted Statistics and Applications 8, no. 2 (2013): 83–84. http://dx.doi.org/10.3233/mas-130255.

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20

Gibbons, Robert R., Donald R. Hedeker, and Alexander von Eye. "Statistical Methods in Longitudinal Research:." Journal of the American Statistical Association 86, no. 416 (1991): 1146. http://dx.doi.org/10.2307/2290546.

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21

Armitage, P., and G. Berry. "Statistical Methods in Medical Research." Biometrics 53, no. 1 (1997): 391. http://dx.doi.org/10.2307/2533132.

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22

Satagopan, Jaya M., and Alex D. Smith. "Statistical Methods in Genomics Research." Heart Drug 3, no. 1 (2003): 48–60. http://dx.doi.org/10.1159/000070907.

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23

Wickham, Carol A. C., P. Armitage, and G. Berry. "Statistical Methods in Medical Research." Journal of the Royal Statistical Society. Series A (Statistics in Society) 151, no. 2 (1988): 361. http://dx.doi.org/10.2307/2982765.

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24

Simpson, Pippa M., John A. Spratt, and John S. Spratt. "Statistical methods in cancer research." Journal of Surgical Oncology 76, no. 3 (2001): 201–23. http://dx.doi.org/10.1002/jso.1035.

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25

Gardner, Bernard. "Statistical methods in cancer research." Journal of Surgical Oncology 78, no. 4 (2001): 281. http://dx.doi.org/10.1002/jso.1170.

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26

Newgard, Craig D., and Roger J. Lewis. "Statistical Methods for Prehospital Care Research." Prehospital Emergency Care 6, sup2 (2002): S9—S17. http://dx.doi.org/10.3109/10903120209102676.

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27

Wegner, Gail D. "Statistical Methods for Health Care Research." Journal of Gerontological Nursing 21, no. 7 (1995): 52. http://dx.doi.org/10.3928/0098-9134-19950701-15.

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28

Sanchis, Juan, Pablo Avanzas, Antoni Bayes-Genis, Leopoldo Pérez de Isla, and Magda Heras. "New Statistical Methods in Cardiovascular Research." Revista Española de Cardiología (English Edition) 64, no. 6 (2011): 499–500. http://dx.doi.org/10.1016/j.rec.2011.01.016.

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29

Hagan, Paul, and Dymphna Fellowes. "Multivariate statistical methods in battery research." Journal of Power Sources 122, no. 1 (2003): 77–84. http://dx.doi.org/10.1016/s0378-7753(03)00344-6.

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30

Marzjarani, Morteza. "Statistical Methods in Social Science Research." Technometrics 62, no. 2 (2020): 1–288. http://dx.doi.org/10.1080/00401706.2020.1744914.

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31

Akimova, O. V., and N. V. Zakharchenko. "THE STATISTICAL METHODS IN PEDAGOGICAL RESEARCH." Innovate Pedagogy 1, no. 20 (2020): 68–71. http://dx.doi.org/10.32843/2663-6085-2020-20-1-14.

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32

Johnson, Marsha. "Statistical Methods for Health Care Research." Gastroenterology Nursing 19, no. 4 (1996): 153. http://dx.doi.org/10.1097/00001610-199607000-00010.

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33

Schinka, John A., Leif LaLone, and Jo Ann Broeckel. "Statistical Methods in Personality Assessment Research." Journal of Personality Assessment 68, no. 3 (1997): 487–96. http://dx.doi.org/10.1207/s15327752jpa6803_2.

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34

Schober, Patrick, and Thomas R. Vetter. "Nonparametric Statistical Methods in Medical Research." Anesthesia & Analgesia 131, no. 6 (2020): 1862–63. http://dx.doi.org/10.1213/ane.0000000000005101.

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35

Lovell, David. "Statistical methods for pharmaceutical research planning." Food and Chemical Toxicology 25, no. 11 (1987): 879. http://dx.doi.org/10.1016/0278-6915(87)90272-9.

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36

Vasovic, Velibor, Sasa Vukmirovic, Momir Mikov, et al. "Influence of bile acid derivates on morphine analgesic effect in mice." Vojnosanitetski pregled 71, no. 8 (2014): 767–71. http://dx.doi.org/10.2298/vsp121010007v.

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Background/Aim. It is known that bile acids improve the absorption, bioavailability and pharmacodynamic characteristics of some drugs. Morphine analgesia is produced by activation of opioid receptors within the central nervous system (CNS) at both spinal and supraspinal levels. Since a morphine molecule contains 3 polar groups and therefore hard to transfer through the blood-brain barrier, the aim of the study was to examine the potential influence of bile acids derivates, namely sodium salt of monoketocholic acid (MKH-Na) and methyl ester of monoketocholic acid (MKH-Me), on analgesic effect o

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37

Bumbăcilă, Bogdan, and Mihai V. Putz. "Neurotoxicity of Pesticides: The Roadmap for the Cubic Mode of Action." Current Medicinal Chemistry 27, no. 1 (2020): 54–77. http://dx.doi.org/10.2174/0929867326666190704142354.

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Pesticides are used today on a planetary-wide scale. The rising need for substances with this biological activity due to an increasing consumption of agricultural and animal products and to the development of urban areas makes the chemical industry to constantly investigate new molecules or to improve the physicochemical characteristics, increase the biological activities and improve the toxicity profiles of the already known ones. Molecular databases are increasingly accessible for in vitro and in vivo bioavailability studies. In this context, structure-activity studies, by their in silico -

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38

Shukla, Arvind Kumar, Sartaj Ahmad, Saurabh Sharma, et al. "Utilization of Statistical Methods in Microbiological Research." International Journal of Contemporary Microbiology 1, no. 1 (2015): 126. http://dx.doi.org/10.5958/2395-1796.2015.00028.9.

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39

Jacob, KS. "Statistical Methods in Psychiatric Research and SPSS." Indian Journal of Psychiatry 58, no. 3 (2016): 356. http://dx.doi.org/10.4103/0019-5545.192008.

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40

Chalmers, Colin, and P. V. Rao. "Statistical Research Methods in the Life Sciences." Mathematical Gazette 83, no. 498 (1999): 569. http://dx.doi.org/10.2307/3621027.

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41

Derringer, George C. "Statistical Methods in Rubber Research and Development." Rubber Chemistry and Technology 61, no. 3 (1988): 377–421. http://dx.doi.org/10.5254/1.3536194.

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Abstract As this article has demonstrated, statistical methods have considerable utility in rubber research and development. Such methods are cost effective and perhaps, more important, help the user to formulate questions in such a way as to make research programs more productive. The use of statistical methods in formulation development have been particularly fruitful. For example, without statistical methods, the compounders common task of simultaneously achieving a specific balance of cost, property levels, and processing behavior would be an expensive undertaking at best and hopeless at w

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42

Topchishvili, Alexander, and Stan Lipovetsky. "Statistical methods in optimization and operations research." Model Assisted Statistics and Applications 6, no. 3 (2011): 161–62. http://dx.doi.org/10.3233/mas-2011-0202.

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GORE, W. L. "STATISTICAL METHODS IN PLASTICS RESEARCH AND DEVELOPMENT." Quality Engineering 2, no. 1 (1989): 81–89. http://dx.doi.org/10.1080/08982118908962699.

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44

Stapleton, John, Robert West, John Marsden, and Wayne Hall. "Research methods and statistical techniques in addiction." Addiction 107, no. 10 (2012): 1724–25. http://dx.doi.org/10.1111/j.1360-0443.2012.03969.x.

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45

Heath, Andrew C., Pamela AF Madden, and Nicholas G. Martin. "Statistical methods in genetic research on smoking." Statistical Methods in Medical Research 7, no. 2 (1998): 165–86. http://dx.doi.org/10.1177/096228029800700205.

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46

Ferrão, Maria Eugénia. "Statistical Methods in Recent Higher Education Research." Journal of College Student Development 61, no. 3 (2020): 366–71. http://dx.doi.org/10.1353/csd.2020.0033.

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47

Heath, A. C., P. A. M. Madden, and N. G. Martin. "Statistical methods in genetic research on smoking." Statistical Methods in Medical Research 7, no. 2 (1998): 165–86. http://dx.doi.org/10.1191/096228098676685170.

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48

Purdie, D. "Statistical Methods in Medical Research, 4th edn." Internal Medicine Journal 33, no. 1-2 (2003): 67. http://dx.doi.org/10.1046/j.1445-5994.2002.00319.x.

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49

Pande, Hemlata, and H. S. Dhami. "Statistical Methods in Language and Linguistic Research." Journal of Quantitative Linguistics 21, no. 3 (2014): 295–97. http://dx.doi.org/10.1080/09296174.2014.911507.

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50

Farnum, Nicholas R. "Statistical Methods." Journal of Quality Technology 22, no. 3 (1990): 252–53. http://dx.doi.org/10.1080/00224065.1990.11979254.

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