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Journal articles on the topic 'Biochemical and biophysical PTs variability'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Asner, Gregory P. "Biophysical and Biochemical Sources of Variability in Canopy Reflectance." Remote Sensing of Environment 64, no. 3 (1998): 234–53. http://dx.doi.org/10.1016/s0034-4257(98)00014-5.

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Enemchukwu, Nduka O., Ricardo Cruz-Acuña, Tom Bongiorno, et al. "Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis." Journal of Cell Biology 212, no. 1 (2015): 113–24. http://dx.doi.org/10.1083/jcb.201506055.

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Epithelial cells cultured within collagen and laminin gels proliferate to form hollow and polarized spherical structures, recapitulating the formation of a rudimentary epithelial organ. However, the contributions of extracellular matrix (ECM) biochemical and biophysical properties to morphogenesis are poorly understood because of uncontrolled presentation of multiple adhesive ligands, limited control over mechanical properties, and lot-to-lot compositional variability in these natural ECMs. We engineered synthetic ECM-mimetic hydrogels with independent control over adhesive ligand density, mec

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Haupt, Christian. "The AL Amyloid Fibril: Looking for a Link between Fibril Formation and Structure." Hemato 2, no. 3 (2021): 505–14. http://dx.doi.org/10.3390/hemato2030032.

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The formation and deposition of fibrils derived from immunglobulin light chains is a hallmark of systemic AL amyloidosis. A particularly remarkable feature of the disease is the diversity and complexity in pathophysiology and clinical manifestations. This is related to the variability of immunoglobulins, as virtually every patient has a variety of mutations resulting in their own unique AL protein and thus a unique fibril deposited in the body. Here, I review recent biochemical and biophysical studies that have expanded our knowledge on how versatile the structure of AL fibrils in patients is

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Unger, N., K. Harper, Y. Zheng, et al. "Photosynthesis-dependent isoprene emission from leaf to planet in a global carbon–chemistry–climate model." Atmospheric Chemistry and Physics Discussions 13, no. 7 (2013): 17717–91. http://dx.doi.org/10.5194/acpd-13-17717-2013.

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Abstract. We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar/Ball–Berry leaf model of photosynthesis and stomatal conductance that is embedded within a global chemistry–climate simulation framework. The isoprene production is calculated as a function of electron transport-limited photosynthesis, intercellular carbon dioxide concentration, and canopy temperature. The vegetation biophysics module computes the photosynthetic uptake of carbon dioxide coupled with the transpiration of water vap

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Unger, N., K. Harper, Y. Zheng, et al. "Photosynthesis-dependent isoprene emission from leaf to planet in a global carbon-chemistry-climate model." Atmospheric Chemistry and Physics 13, no. 20 (2013): 10243–69. http://dx.doi.org/10.5194/acp-13-10243-2013.

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Abstract. We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar–Ball–Berry leaf model of photosynthesis and stomatal conductance that is embedded within a global chemistry-climate simulation framework. The isoprene production is calculated as a function of electron transport-limited photosynthesis, intercellular and atmospheric carbon dioxide concentration, and canopy temperature. The vegetation biophysics module computes the photosynthetic uptake of carbon dioxide coupled with the transpirat

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Coward, Jesse, Matthew Hathorn, Volkan Karabacak, Orly Even Dar, and Grégoire Altan-Bonnet. "Single-cell heterogeneity analysis provides rapid validation of biophysical parameters in living cells and quantifies heterogeneous sensitivity to interleukin-2, -7, and -15. (57.12)." Journal of Immunology 186, no. 1_Supplement (2011): 57.12. http://dx.doi.org/10.4049/jimmunol.186.supp.57.12.

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Abstract The single-cell resolution of flow cytometry provides a quantitative measurement of the heterogeneity of protein expression within clonal populations of cells. As the biological significance of this variability is becoming more widely appreciated, there is a need for new tools and methodology to analyze and leverage the effects of endogenous variation. These tools can provide alternatives to genetic methods, such as siRNA knockdown or germline knockout, that are commonly used to manipulate protein expression. We introduce such a new tool, named ScatterSlice, that enables rapid quantif

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Abiakam, Nkemjika S., Hemalatha Jayabal, Shabira Abbas, Davide Filingeri, Dan L. Bader, and Peter R. Worsley. "The Effects of Incontinence Pad Application on Loaded Skin With Reference to Biophysical and Biochemical Parameters." Journal of Wound, Ostomy & Continence Nursing 50, no. 6 (2023): 512–20. http://dx.doi.org/10.1097/won.0000000000001032.

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PURPOSE: The purpose of this study was to evaluate temporal changes in skin responses following exposure to moisture alone or moisture in combination with mechanical loading. DESIGN: Comparison cohort with a repeated-measures design. SUBJECTS AND SETTINGS: The sample comprised 12 healthy volunteers. Participants were purposely sampled from 2 different age groups; half were 32 to 39 years old and half were 50 to 62 years old. Participants identified as White, Black, or mixed; 83% (n = 10) identified as White; 8 (67%) were female. METHODS: Four sites at the sacrum were challenged with the applic

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La Gatta, Annalisa, Maria Aschettino, Antonietta Stellavato, et al. "Hyaluronan Hydrogels for Injection in Superficial Dermal Layers: An In Vitro Characterization to Compare Performance and Unravel the Scientific Basis of Their Indication." International Journal of Molecular Sciences 22, no. 11 (2021): 6005. http://dx.doi.org/10.3390/ijms22116005.

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Background: Skinboosters represent the latest category of hyaluronan (HA) hydrogels released for aesthetic purposes. Different from originally developed gels, they are intended for more superficial injections, claiming a skin rejuvenation effect through hydration and possibly prompting biochemical effects in place of the conventional volumetric action. Here, three commercial skinboosters were characterized to unravel the scientific basis for such indication and to compare their performances. Methods: Gels were evaluated for water-soluble/insoluble-HA composition, rheology, hydration, cohesivit

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Bouanene, Houda, and Abdelhédi Miled. "Conflicting Views on the Molecular Structure of the Cancer Antigen CA125/MUC16." Disease Markers 28, no. 6 (2010): 385–94. http://dx.doi.org/10.1155/2010/918457.

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CA125 is a tumor antigen used to monitor the progression and regression of epithelial ovarian cancer. Despite the widespread use of CA125, the biochemical and molecular nature of this antigen is poorly understood. Analysis of the structure of CA125 is essential for determining the physiological role of this very significant tumor marker. Accumulated experimental evidence has shown that CA125 epitopes reside on a molecule of very complex architecture in terms of both protein backbone and oligosaccharide structures. It is not clear whether the heterogeneity of CA125 molecular characteristics are

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Takagi, Jun, and Yuta Shimamoto. "High-quality frozen extracts of Xenopus laevis eggs reveal size-dependent control of metaphase spindle micromechanics." Molecular Biology of the Cell 28, no. 16 (2017): 2170–77. http://dx.doi.org/10.1091/mbc.e17-03-0174.

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Cell-free extracts from unfertilized Xenopus laevis eggs offer the opportunity for a variety of biochemical and biophysical assays for analyzing essential cell cycle events such as metaphase spindle assembly. However, the extracts often exhibit substantial variation in quality and have low storage stability, factors that hamper their experimental utility. Here we report a simple two-step method for preparing frozen egg extracts that retain spindle assembly activity levels similar to those of freshly prepared extracts. Extract degradation associated with the freeze–thaw process can be substanti

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Orgeig, Sandra, Janna L. Morrison, and Christopher B. Daniels. "Evolution, Development, and Function of the Pulmonary Surfactant System in Normal and Perturbed Environments." Comprehensive Physiology 6, no. 1 (2016): 363–422. https://doi.org/10.1002/j.2040-4603.2016.tb00674.x.

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ABSTRACTSurfactant lipids and proteins form a surface active film at the air‐liquid interface of internal gas exchange organs, including swim bladders and lungs. The system is uniquely positioned to meet both the physical challenges associated with a dynamically changing internal air‐liquid interface, and the environmental challenges associated with the foreign pathogens and particles to which the internal surface is exposed. Lungs range from simple, transparent, bag‐like units to complex, multilobed, compartmentalized structures. Despite this anatomical variability, the surfactant system is r

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Morcillo-Pallarés, Pablo, Juan Pablo Rivera-Caicedo, Santiago Belda, et al. "Quantifying the Robustness of Vegetation Indices through Global Sensitivity Analysis of Homogeneous and Forest Leaf-Canopy Radiative Transfer Models." Remote Sensing 11, no. 20 (2019): 2418. http://dx.doi.org/10.3390/rs11202418.

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Vegetation indices (VIs) are widely used in optical remote sensing to estimate biophysical variables of vegetated surfaces. With the advent of spectroscopy technology, spectral bands can be combined in numerous ways to extract the desired information. This resulted in a plethora of proposed indices, designed for a diversity of applications and research purposes. However, it is not always clear whether they are sensitive to the variable of interest while at the same time, responding insensitive to confounding factors. Hence, to be able to quantify the robustness of VIs, a systematic evaluation

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Pensalfini, Marco, and Adrian Buganza Tepole. "Mechano-biological and bio-mechanical pathways in cutaneous wound healing." PLOS Computational Biology 19, no. 3 (2023): e1010902. http://dx.doi.org/10.1371/journal.pcbi.1010902.

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Injuries to the skin heal through coordinated action of fibroblast-mediated extracellular matrix (ECM) deposition, ECM remodeling, and wound contraction. Defects involving the dermis result in fibrotic scars featuring increased stiffness and altered collagen content and organization. Although computational models are crucial to unravel the underlying biochemical and biophysical mechanisms, simulations of the evolving wound biomechanics are seldom benchmarked against measurements. Here, we leverage recent quantifications of local tissue stiffness in murine wounds to refine a previously-proposed

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Hsu, Miles, Xinhe Shan, Samuel U. Takvorian, et al. "Implementing ¹⁸F-DCFPyL PET in clinical practice: Prescribing patterns and utilization at a large academic center." Journal of Clinical Oncology 41, no. 6_suppl (2023): 42. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.42.

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42 Background: 18F-DCFPyL imaging was recently approved for initial staging in patients (pts) with prostate cancer and suspected metastasis and for those with biochemical recurrence (BCR). 18F-DCFPyL recently became available at our NCI-Designated Comprehensive Cancer Center comprising 6 teaching hospitals and 2 outpatient facilities. As real-world data on 18F-DCFPyL usage in the US are lacking, our objective was to describe prescription patterns and utilization for 18F-DCFPyL. Methods: We identified 18F-DCFPyL scans performed at our center from 1/1/2022-5/10/2022 and abstracted corresponding

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Aguado-García, Alejandro, Daniel A. Priego-Espinosa, Andrés Aldana, Alberto Darszon, and Gustavo Martínez-Mekler. "Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation." PLOS ONE 16, no. 11 (2021): e0245816. http://dx.doi.org/10.1371/journal.pone.0245816.

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Capacitation is a complex maturation process mammalian sperm must undergo in the female genital tract to be able to fertilize an egg. This process involves, amongst others, physiological changes in flagellar beating pattern, membrane potential, intracellular ion concentrations and protein phosphorylation. Typically, in a capacitation medium, only a fraction of sperm achieve this state. The cause for this heterogeneous response is still not well understood and remains an open question. Here, one of our principal results is to develop a discrete regulatory network, with mostly deterministic dyna

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Firozjaei, Mohammad Karimi, Solmaz Fathololoumi, Qihao Weng, Majid Kiavarz, and Seyed Kazem Alavipanah. "Remotely Sensed Urban Surface Ecological Index (RSUSEI): An Analytical Framework for Assessing the Surface Ecological Status in Urban Environments." Remote Sensing 12, no. 12 (2020): 2029. http://dx.doi.org/10.3390/rs12122029.

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Urban Surface Ecological Status (USES) reflects the structure and function of an urban ecosystem. USES is influenced by the surface biophysical, biochemical, and biological properties. The assessment and modeling of USES is crucial for sustainability assessment in support of achieving sustainable development goals such as sustainable cities and communities. The objective of this study is to present a new analytical framework for assessing the USES. This analytical framework is centered on a new index, Remotely Sensed Urban Surface Ecological index (RSUSEI). In this study, RSUSEI is used to ass

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Sanchez, Larysa, Erin Moshier, Alexander Coltoff, et al. "Outcomes in Multiple Myeloma Patients Progressing on Lenalidomide Maintenance." Blood 134, Supplement_1 (2019): 1779. http://dx.doi.org/10.1182/blood-2019-128441.

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Introduction: Lenalidomide (R) maintenance therapy in multiple myeloma (MM) has been shown to improve progression-free survival (PFS) and overall survival (OS) after autologous stem-cell transplantation (ASCT). Even in the transplant ineligible population, R until progression is associated with improved PFS. The ever-increasing use of R maintenance therapy, however, eventually leads to refractoriness to R at maintenance doses. Moreover, clinical trials with len-dex (Rd) backbone regimens including daratumumab, elotuzumab, ixazomib, and carfilzomib have all excluded such patients (pts). This is

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Kobayashi, Tetsuya J., and Atsushi Kamimura. "2SF-02 Information Processing via Noisy Biochemical Channels(2SF Inherent variability and information coding in biological systems,Symposium,The 50th Annual Meeting of the Biophysical Society of Japan)." Seibutsu Butsuri 52, supplement (2012): S14. http://dx.doi.org/10.2142/biophys.52.s14_1.

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Ballesteros, Daniel, Hugh W. Pritchard, and Christina Walters. "Dry architecture: towards the understanding of the variation of longevity in desiccation-tolerant germplasm." Seed Science Research 30, no. 2 (2020): 142–55. http://dx.doi.org/10.1017/s0960258520000239.

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AbstractDesiccation-tolerant (DT) plant germplasm (i.e. seeds, pollen and spores) survive drying to low moisture contents, when cytoplasm solidifies, forming a glass, and chemical reactions are slowed. DT germplasm may survive for long periods in this state, though inter-specific and intra-specific variation occurs and is not currently explained. Such variability has consequences for agriculture, forestry and biodiversity conservation. Longevity was previously considered in the context of morphological features, cellular constituents or habitat characteristics. We suggest, however, that a biop

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20

Frigerio, Roberto, Angelo Musicò, Marco Brucale, et al. "Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols towards Downstream Isolation and Analysis." Cells 10, no. 3 (2021): 544. http://dx.doi.org/10.3390/cells10030544.

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Since the outbreak of the COVID-19 crisis, the handling of biological samples from confirmed or suspected SARS-CoV-2-positive individuals demanded the use of inactivation protocols to ensure laboratory operators’ safety. While not standardized, these practices can be roughly divided into two categories, namely heat inactivation and solvent-detergent treatments. These routine procedures should also apply to samples intended for Extracellular Vesicles (EVs) analysis. Assessing the impact of virus-inactivating pre-treatments is therefore of pivotal importance, given the well-known variability int

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Suarez, Luz Angelica, Andrew Robson, John McPhee, Julie O’Halloran, and Celia van Sprang. "Accuracy of carrot yield forecasting using proximal hyperspectral and satellite multispectral data." Precision Agriculture 21, no. 6 (2020): 1304–26. http://dx.doi.org/10.1007/s11119-020-09722-6.

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Abstract Proximal and remote sensors have proved their effectiveness for the estimation of several biophysical and biochemical variables, including yield, in many different crops. Evaluation of their accuracy in vegetable crops is limited. This study explored the accuracy of proximal hyperspectral and satellite multispectral sensors (Sentinel-2 and WorldView-3) for the prediction of carrot root yield across three growing regions featuring different cropping configurations, seasons and soil conditions. Above ground biomass (AGB), canopy reflectance measurements and corresponding yield measures

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Lamba, S. S., K. Y. Such, and H. Lewis Ill. "The Potential Use of Hydroxyurea as Treatment for Sickle Cell Disease." Current Medicinal Chemistry 1, no. 5 (1995): 366–75. http://dx.doi.org/10.2174/092986730105220216101649.

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Abstract: Recent biochemical and biophysical studies of sickle cell hemoglobin have provided valuable insight into the molecular basis of the sickling phenomenon in sickle cell disease. A large number of compounds have been examined for antisickling potential. These can be characterized as noncovalent or covalent in their mechanism of action. Examples of noncovalent agents include: alkylureas, dimethyl sulfoxide, dimethylforma mide, small peptides, etc. Examples of covalent agents include: nitrogen mustard, glyceraldehyde, aldehydic pyridoxal derivatives, dimethyladipimidate, etc. Also, acyl

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Cole, John A., Joseph R. Peterson, Tyler M. Earnest, et al. "SimBioSys TumorScope: Spatio-temporal modeling of the tumor microenvironment to predict chemotherapeutic response." Journal of Clinical Oncology 38, no. 15_suppl (2020): e12650-e12650. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12650.

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e12650 Background: One of the most important sources of variability affecting each patient’s response to neoadjuvant chemotherapy (NACT) is drug and nutrient perfusion, The SimBioSys TumorScope is a computational decision-support system that is designed to predict the flow of drugs and nutrients throughout the tumor microenvironment, and the subsequent response of the tumor to treatment. By enabling healthcare providers to simulate a range of different standard-of-care treatment regimens in a realistic 3D model of each patient’s tumor, providers can predict which treatments are most effective,

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Balde, Hamadou, Gabriel Hmimina, Yves Goulas, Gwendal Latouche, Abderrahmane Ounis, and Kamel Soudani. "Data-based investigation of the effects of canopy structure and shadows on chlorophyll fluorescence in a deciduous oak forest." Biogeosciences 21, no. 5 (2024): 1259–76. http://dx.doi.org/10.5194/bg-21-1259-2024.

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Abstract. Data from satellite, aircraft, drone, and ground-based measurements have already shown that canopy-scale sun-induced chlorophyll fluorescence (SIF) is tightly related to photosynthesis, which is linked to vegetation carbon assimilation. However, our ability to effectively use those findings are hindered by confounding factors, including canopy structure, fluctuations in solar radiation, and sun–canopy geometry that highly affect the SIF signal. Thus, disentangling these factors has become paramount in order to use SIF for monitoring vegetation functioning at the canopy scale and beyo

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Rossini, M., S. Cogliati, M. Meroni, et al. "Remote sensing-based estimation of gross primary production in a subalpine grassland." Biogeosciences Discussions 9, no. 2 (2012): 1711–58. http://dx.doi.org/10.5194/bgd-9-1711-2012.

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Abstract. This study investigates the performances in a terrestrial ecosystem of gross primary production (GPP) estimation of a suite of spectral vegetation indexes (VIs) that can be computed from currently orbiting platforms. Vegetation indexes were computed from near-surface field spectroscopy measurements collected using an automatic system designed for high temporal frequency acquisition of spectral measurements in the visible near-infrared region. Spectral observations were collected for two consecutive years in Italy in a subalpine grassland equipped with an Eddy Covariance (EC) flux tow

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Rossini, M., S. Cogliati, M. Meroni, et al. "Remote sensing-based estimation of gross primary production in a subalpine grassland." Biogeosciences 9, no. 7 (2012): 2565–84. http://dx.doi.org/10.5194/bg-9-2565-2012.

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Abstract. This study investigates the performances in a terrestrial ecosystem of gross primary production (GPP) estimation of a suite of spectral vegetation indexes (VIs) that can be computed from currently orbiting platforms. Vegetation indexes were computed from near-surface field spectroscopy measurements collected using an automatic system designed for high temporal frequency acquisition of spectral measurements in the visible near-infrared region. Spectral observations were collected for two consecutive years in Italy in a subalpine grassland equipped with an eddy covariance (EC) flux tow

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Díaz, Alejandra I. Ferrer, and John Huang. "Abstract 4209: Unraveling the effects of the microenvironment on glioblastoma multiforme invasiveness using a xeno-free 3D hydrogel platform." Cancer Research 84, no. 6_Supplement (2024): 4209. http://dx.doi.org/10.1158/1538-7445.am2024-4209.

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Abstract Glioblastoma multiforme (GBM) is a grade IV astrocytoma and the most common type of adult brain malignancy. The overall survival of patients diagnosed with GBM is less than 5 years. Therefore, it is imperative to understand the mechanisms contributing to GBM progression, invasiveness, and survival. This study aimed to evaluate the effect of the extracellular matrix (ECM) on GBM cell invasion by performing the traditional invasion assay as well as novel in vitro invasion assay strategies. A significant challenge with in vitro cell invasion assays is the use of animal-based ECM: the com

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28

Ivankova, V., E. Domina, T. Khrulenko, L. Baranovska, and O. Hrinchenko. "IRIDIUM-192 RADIOTHERAPY BENEFITS IN THE MANAGEMENT OF GYNECOLOGICAL TUMORS." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 25 (2020): 569–78. http://dx.doi.org/10.33145/2304-8336-2020-25-569-578.

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Background. Application of the most advanced radiation technologies of brachytherapy featuring the high dose rate sources i.e. 60Co and 192Ir within contemporary management protocols for gynecological cancer provides maximum dose distribution in the clinical target along with minimal radiation exposure on surrounding organs and tissues. It involves irradiation of large spaces with delivery of high therapeutic doses at the tolerance bound of «critical» organs (bladder, rectum) and tissues. Thus minimization of the early and late radiation complications, life span extent and quality of life incr

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Dean, Melinda M., Katrina Kildey, Thu V. Tran, Kelly Rooks, Shoma Baidya та Robert L. Flower. "Single Nucleotide Variations In Spectrin-1β Accentuate The Red Blood Cell Storage Lesion". Blood 122, № 21 (2013): 3422. http://dx.doi.org/10.1182/blood.v122.21.3422.3422.

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Abstract Introduction During routine storage packed red blood cells (PRBC) undergo biochemical and biophysical changes collectively referred to as the “RBC storage lesion”. Donor-to-donor variability in the severity of the storage lesion has been reported. The extent to which donor-associated differences in blood component storage affect blood product quality and post-transfusion outcome remains unknown. Murine models with single nucleotide variants (SNV) in gene encoding spectrin-1β were used to investigate the impact of mutations on the RBC storage lesion. Methods Two murine lineages with N-

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Dean, Melinda M., Luke D. Samson, Kelly Rooks, Jesse Fryk, Shoma Baidya, and Robert L. Flower. "Donor Variation In Biological Mediators During Storage Of Packed Red Blood Cells." Blood 122, no. 21 (2013): 3655. http://dx.doi.org/10.1182/blood.v122.21.3655.3655.

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Abstract Introduction During routine storage, packed red blood cells (PRBC) undergo numerous biochemical and biophysical changes collectively referred to as the “RBC storage lesion”. A number of factors reported to accumulate during the routine storage of PRBCs are hypothesized to mediate inflammatory cell responses and contribute to poor patient outcomes following transfusion. In addition, donor variability in red blood cell (RBC) characteristics and onset of the storage lesion has been reported. We investigated changes in levels of potential biological response modifies in the supernatant (S

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Islamzada, Emel, Kerryn Matthews, Erik Lamoureux, Mark D. Scott, and Hongshen Ma. "Degradation of Red Blood Cell Deformability during Cold Storage in Blood Bags." Blood 138, Supplement 1 (2021): 2143. http://dx.doi.org/10.1182/blood-2021-153760.

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Abstract RBC transfusions are a life-saving procedure, aiding both chronic and acute patients in restoring tissue oxygenation. The ability to store collected RBC units for prolonged periods has been one of the most transformative advances in medicine, significantly improving the reliability and the speed of access to blood. However, RBCs undergo a number of metabolic, structural, and biochemical changes during storage, collectively known as the storage lesion, that is detrimental to the quality of the RBC. A major challenge is the ability to evaluate the extent of the storage lesion, and thus

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Imran, Hafiz Ali, Karolina Sakowska, Damiano Gianelle та ін. "Assessing plant trait diversity as an indicators of species α‐ and β‐diversity in a subalpine grassland of the Italian Alps". Remote Sensing in Ecology and Conservation, 30 жовтня 2023. http://dx.doi.org/10.1002/rse2.370.

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AbstractAs the need for ecosystem biodiversity assessment increases within the climate crisis framework, more and more studies using spectral variation hypothesis (SVH) are proposed to assess biodiversity at various scales. The SVH implies optical diversity (also called spectral diversity) is driven by light absorption dynamics associated with plant traits (PTs) variability (which is an indicator of functional diversity) which is, in turn, determined by biodiversity. In this study, we examined the relationship between PTs variability, optical diversity and α‐ and β‐diversity at different taxon

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Mohana, J., M. Murugan, T. Srinivasan, D. Kavithamani, P. Meenakshi, and K. Prakash. "Biophysical and biochemical parameters of Sorghum associated to shoot fly resistance." Plant Science Today 11, sp4 (2024). http://dx.doi.org/10.14719/pst.5220.

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The sorghum shoot fly, Atherigona soccata (Muscidae: Diptera), represents a significant biotic constraint to sorghum production, leading to considerable yield losses globally. This study aimed to systematically classify sorghum genotypes based on their resistance to A. soccata infestation. A total of 188 genotypes were subjected to rigorous evaluation employing standardized screening methodologies. The analysis revealed substantial variability in resistance levels across the genotypes. Based on damage assessments in field trials, 14 genotypes were selected for further investigation under contr

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Lin, Shuyu, Jialun Zhu, Wenzhuo Yu, et al. "A touch-based multimodal and cryptographic bio-human–machine interface." Proceedings of the National Academy of Sciences 119, no. 15 (2022). http://dx.doi.org/10.1073/pnas.2201937119.

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Significance The awareness of the individuals’ biological status is critical for creating interactive environments. Accordingly, we devised a multimodal cryptographic bio-human–machine interface (CB-HMI), which seamlessly translates touch-based entries into encrypted biochemical, biophysical, and biometric indices (i.e., circulating biomarkers levels, heart rate, oxygen saturation level, and fingerprint pattern). As its central component, the CB-HMI features thin hydrogel-coated chemical sensors and a signal interpretation framework to access/interpret biochemical indices, bypassing the challe

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Rossi, Federica, Luigi Manfrini, Melissa Venturi, Luca Corelli Grappadelli, and Brunella Morandi. "Fruit transpiration drives interspecific variability in fruit growth strategies." Horticulture Research 9 (2022). http://dx.doi.org/10.1093/hr/uhac036.

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Abstract Fruit growth is a complex mechanism resulting from biochemical and biophysical events leading water and dry matter to accumulate in the fruit tissues. Understanding how fruits choose their growth strategies can help growers optimizing their resource management for a more sustainable production and a higher fruit quality. This paper compares the growth strategies adopted by different fruit crops, at different times during the season and relates their fruit surface conductance to key physiological parameters for fruit growth such as phloem and xylem inflows as well transpiration losses.

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Petrovic, Ivana, Stephan Grzesiek, and Polina Isaikina. "Advances in the molecular understanding of GPCR-arrestin complexes." Biochemical Society Transactions, November 7, 2024. http://dx.doi.org/10.1042/bst20240170.

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Arrestins are essential proteins for the regulation of G protein-coupled receptors (GPCRs). They mediate GPCR desensitization after the activated receptor has been phosphorylated by G protein receptor kinases (GRKs). In addition, GPCR-arrestin interactions may trigger signaling pathways that are distinct and independent from G proteins. The non-visual GPCRs encompass hundreds of receptors with varying phosphorylation patterns and amino acid sequences, which are regulated by only two human non-visual arrestin isoforms. This review describes recent findings on GPCR-arrestin complexes, obtained b

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Li, Yitao, Zhao‐Liang Li, Hua Wu, et al. "Biophysical Impact of Multiple Surface Forcings on Land Surface Temperature Over Eastern China." Journal of Geophysical Research: Atmospheres 128, no. 20 (2023). http://dx.doi.org/10.1029/2023jd039315.

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AbstractOver the past decades, human activities have directly or indirectly driven the land surface changes in eastern China. These anthropogenic forcings could trigger biochemical feedback and alter the surface biophysical properties, thus affecting local temperature. However, the latter is recognized as the “noise” and ignored when assessing historical or future climate. Here, we adopt the “observation minus reanalysis” (OMR) method to isolate the biophysical temperature footprint of multiple surface changes in eastern China over 2001–2018, using remote sensing land surface temperature and r

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Anvesh, K., Shivani Choudhary, K. C. Kumawat, G. K. Mittal, and Kiran Gaur. "Morphological and Biochemical Basis of Resistance in Indian Bean, Lablab purpureus var. typicus (L.) Sweet Varieties against Pod Borers." LEGUME RESEARCH - AN INTERNATIONAL JOURNAL, Of (August 10, 2021). http://dx.doi.org/10.18805/lr-4665.

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Background: Indian bean, Lablab purpureus var. typicus (L.) Sweet (family: Fabaceae) is an important vegetable crop in India and other countries. The main reasons of variability in the pattern of resistance shown by different genotypes were explained by Painter (1951). Antibiosis is an adverse impact of the host plant on the biology of the insect pests and their progeny due to the biochemical and biophysical factors present in it. Methods: The experiment was laid out in a simple randomized block design (RBD) with seven treatments, each replicated thrice. The plot size was 1.8x1.8 m2 keeping ro

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Huggannavar, Vinayak, and Indu J. "Coupled Weather-Biosphere Model (WRF-VPRM) Response to Extreme Land Cover Scenarios Over Ganga Basin: A Cross Component Analysis." Environmental Research Communications, July 24, 2023. http://dx.doi.org/10.1088/2515-7620/acea1e.

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Abstract Deforestation can have both biophysical and biochemical effects. In our study we evaluate the impacts of extreme idealized land cover scenarios over Ganga basin, India using an online coupled weather-biosphere model. We present an analysis of the carbon stored, based on introduced afforestation (AFF) and deforestation (DEF) in the Ganga basin of India. WRF-VPRM model simulations were carried out at horizontal resolution of 20 km using optimized downscaling configuration. For DEF case, we found two-fold increase in surface temperatures whereas, AFF scenario exhibited cooling effect. Th

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Hembrom, Richard, Renáta Ünnep, Éva Sárvári, Gergely Nagy, and Katalin Solymosi. "Dynamic in vivo monitoring of granum structural changes of Ctenanthe setosa (Roscoe) Eichler during drought stress and subsequent recovery." Physiologia Plantarum 177, no. 1 (2025). https://doi.org/10.1111/ppl.14621.

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AbstractInvestigating the effects of drought stress and subsequent recovery on the structure and function of chloroplasts is essential to understanding how plants adapt to environmental stressors. We investigated Ctenanthe setosa (Roscoe) Eichler, an ornamental plant that can tolerate prolonged drought periods (40 and 49 days of water withdrawal). Conventional biochemical, biophysical, physiological and (ultra)structural methods combined for the first time in a higher plant with in vivo small‐angle neutron scattering (SANS) were used to characterize the alterations induced by drought stress an

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Capó‐Bauçà, Sebastià, Concepción Iñiguez, and Jeroni Galmés. "The diversity and coevolution of Rubisco and CO₂ concentrating mechanisms in marine macrophytes." New Phytologist, January 10, 2024. http://dx.doi.org/10.1111/nph.19528.

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SummaryThe kinetic properties of Rubisco, the most important carbon‐fixing enzyme, have been assessed in a small fraction of the estimated existing biodiversity of photosynthetic organisms. Until recently, one of the most significant gaps of knowledge in Rubisco kinetics was marine macrophytes, an ecologically relevant group including brown (Ochrophyta), red (Rhodophyta) and green (Chlorophyta) macroalgae and seagrasses (Streptophyta). These organisms express various Rubisco types and predominantly possess CO2‐concentrating mechanisms (CCMs), which facilitate the use of bicarbonate for photosy

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Pierella Karlusich, Juan José, Chris Bowler, and Haimanti Biswas. "Carbon Dioxide Concentration Mechanisms in Natural Populations of Marine Diatoms: Insights From Tara Oceans." Frontiers in Plant Science 12 (April 30, 2021). http://dx.doi.org/10.3389/fpls.2021.657821.

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Marine diatoms, the most successful photoautotrophs in the ocean, efficiently sequester a significant part of atmospheric CO2 to the ocean interior through their participation in the biological carbon pump. However, it is poorly understood how marine diatoms fix such a considerable amount of CO2, which is vital information toward modeling their response to future CO2 levels. The Tara Oceans expeditions generated molecular data coupled with in situ biogeochemical measurements across the main ocean regions, and thus provides a framework to compare diatom genetic and transcriptional flexibility u

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Hellmich, Christian, Niketa Ukaj, Bart Smeets, et al. "Hierarchical Biomechanics: Concepts, Bone as Prominent Example, and Perspectives Beyond." Applied Mechanics Reviews, July 18, 2022. http://dx.doi.org/10.1115/1.4055032.

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Abstract Biological materials and systems are hierarchically organized.The main motivation for hierarchical biomechanics is that the wide variability of mechanical properties encountered at the macroscopic scale may be traced back to just a few universal. i.e. tissue-invariant, mechanical properties of elementary components at a sufficiently small scale (such as collagen, elastin, and water in case of soft tissues; complemented by hydroxyapatite in case of hard tissues), and to the nano and microstructures which the latter build up. This challenging task requires a physically rigorous and math

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Li, Huijie, Jianhe Yuan, Gavin Fennell, et al. "Recent advances in wearable sensors and data analytics for continuous monitoring and analysis of biomarkers and symptoms related to COVID-19." Biophysics Reviews 4, no. 3 (2023). http://dx.doi.org/10.1063/5.0140900.

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The COVID-19 pandemic has changed the lives of many people around the world. Based on the available data and published reports, most people diagnosed with COVID-19 exhibit no or mild symptoms and could be discharged home for self-isolation. Considering that a substantial portion of them will progress to a severe disease requiring hospitalization and medical management, including respiratory and circulatory support in the form of supplemental oxygen therapy, mechanical ventilation, vasopressors, etc. The continuous monitoring of patient conditions at home for patients with COVID-19 will allow e

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Chongtham, Anjalika, Marissa Farinas, Diede Broekaart, et al. "Unraveling the molecular mechanisms underlying neocortical tau propagation in Alzheimer’s disease to reveal novel insights into clinical heterogeneity." Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.084995.

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AbstractBackgroundHeterogeneity in the progression of clinical dementia poses a significant challenge, impeding the effectiveness of current therapies for Alzheimer’s disease (AD). To decipher the molecular mechanisms governing heterogeneity in AD progression that remains a critical knowledge gap precluding rational therapeutic design, we investigated the biochemical and biophysical properties of tau present in the inferior temporal gyrus (ITG) and prefrontal cortex (PFC) brain regions of AD patients who had varying disease progression rates. To explore gene expression changes in the ITG which

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Frigerio, Roberto, Angelo Musicò, Marco Brucale, et al. "Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols towards Downstream Isolation and Analysis." March 4, 2021. https://doi.org/10.3390/cells10030544.

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Since the outbreak of the COVID-19 crisis, the handling of biological samples from confirmed or suspected SARS-CoV-2-positive individuals demanded the use of inactivation protocols to ensure laboratory operators’ safety. While not standardized, these practices can be roughly divided into two categories, namely heat inactivation and solvent-detergent treatments. These routine procedures should also apply to samples intended for Extracellular Vesicles (EVs) analysis. Assessing the impact of virus-inactivating pre-treatments is therefore of pivotal importance, given the well-known variabili

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"Comparison of High Range and Low Range of Sensor eAG and 24-Hour Daily GF Using 3+ years of Continuous Glucose Monitoring Sensor Device Collected Data Based on GH-Method: Math-Physical Medicine (No. 458)." Advances in Bioengineering and Biomedical Science Research 4, no. 3 (2022). http://dx.doi.org/10.33140/abbsr.04.03.003.

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Since 5/5/2018, the author utilized a continuous glucose monitoring (CGM) sensor device to collect his glucoses 96 times each day. He then calculates his average daily sensor glucoses (eAG) and sensor glucose fluctuation (GF) within a 24-hour period each. His GF is defined as the maximum glucose value minus the minimum glucose value within a day. The definition of “eAG” is the mean value of glucose data that is similar to HbA1C which is useful in diabetes control. Moreover, the glucose excursion or GF has noticeable influences on various diabetes complications. During the period of 1,218 days

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Krupczak, Brandon, Camille Farruggio, and Krystyn J. Van Vliet. "Manufacturing mesenchymal stromal cells in a microcarrier-microbioreactor platform can enhance cell yield and quality attributes: case study for acute respiratory distress syndrome." Journal of Translational Medicine 22, no. 1 (2024). http://dx.doi.org/10.1186/s12967-024-05373-7.

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AbstractMesenchymal stem and stromal cells (MSCs) hold potential to treat a broad range of clinical indications, but clinical translation has been limited to date due in part to challenges with batch-to-batch reproducibility of potential critical quality attributes (pCQAs) that can predict potency/efficacy. Here, we designed and implemented a microcarrier-microbioreactor approach to cell therapy manufacturing, specific to anchorage-dependent cells such as MSCs. We sought to assess whether increased control of the biochemical and biophysical environment had the potential to create product with

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Warchol-Celinska, E., A. Mazurek-Kula, P. Gladysz-Piestrzynska, et al. "Current practice of care for adolescent and adult patients after Fontan operation in Poland." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.1631.

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Abstract Introduction For the recent decades advances in surgical and medical care have led to rapid growth in the population of adults after Fontan operation. These patients require regular surveillance testing for both cardiovascular status and multiorgan complications and comorbidities. The practice of care for patients after Fontan operation in Poland has not been systematically evaluated. We conducted an observational study in which frequency and selection of surveillance testing at large centers specialized in congenital heart diseases across Poland were investigated on the basis of mult

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Angoulvant, D., P. Amarenco, A. Bastien, et al. "Design of knowledge-based mechanistic model of atherosclerotic cardiovascular disease for in silico trials." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.2944.

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Abstract In silico trials applying a computational model (CM) of atherosclerotic cardiovascular disease (ASCVD) to virtual patients receiving alternative treatments provide an attractive option to complement randomised clinical trials (RCTs) by adding comparative effectiveness data and facilitating the demonstration of drug benefit. In silico modelling allows comparison between treatments with each virtual patient being his own control, and is not limited by the number of patients, comparative arms or trial duration. This study aims at building a knowledge-based mechanistic model of ASCVD. Onc

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