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Journal articles on the topic 'Biochemical Mice'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Leung, Gordon K., Walter K. Schmidt, Martin O. Bergo, et al. "Biochemical Studies ofZmpste24-deficient Mice." Journal of Biological Chemistry 276, no. 31 (2001): 29051–58. http://dx.doi.org/10.1074/jbc.m102908200.

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2

Choudhury, Chinmoy, Meenakshi Bawari, and G. D. Sharma G. D. Sharma. "Biochemical Screening of The Effect of a Plant Extract on Albino Mice Physiology." International Journal of Scientific Research 2, no. 8 (2012): 38–39. http://dx.doi.org/10.15373/22778179/aug2013/13.

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3

Calhoun, S. W., M. D. Engstrom, and I. F. Greenbaum. "Biochemical Variation in Pygmy Mice (Baiomys)." Journal of Mammalogy 70, no. 2 (1989): 374–81. http://dx.doi.org/10.2307/1381521.

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4

Sharma, Archana, Deepak Bhatnagar, and Rashmi Sisodia. "10 Ghz Microwaves Induced Biochemical, Learning and Memory Alterations in Swiss Albino Mice Brain." Indian Journal of Applied Research 4, no. 5 (2011): 1–5. http://dx.doi.org/10.15373/2249555x/may2014/215.

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5

Banchaabouchi, Mumna Al, Bart Marescau, Rudi D'Hooge, et al. "Biochemical and histopathological changes in nephrectomized mice." Metabolism 47, no. 3 (1998): 355–61. http://dx.doi.org/10.1016/s0026-0495(98)90271-2.

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6

Monfared, A. Louei. "Biochemical toxicity of phenol in treated mice." Toxicology Letters 196 (July 2010): S106. http://dx.doi.org/10.1016/j.toxlet.2010.03.378.

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7

Ukpo, GraceE, O. A. T. Ebuehi, and AA Kareem. "Evaluation of moxifloxacin-induced biochemical changes in mice." Indian Journal of Pharmaceutical Sciences 74, no. 5 (2012): 454. http://dx.doi.org/10.4103/0250-474x.108422.

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8

Cardona, Maria E., Elisabeth Norin, and Tore Midtvedt. "Biochemical Functions of Bacillus licheniformis in Gnotobiotic Mice." Microbial Ecology in Health and Disease 15, no. 1 (2003): 40–42. http://dx.doi.org/10.1080/08910600310012045.

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9

Tanu, Tanzina, Adiba Anjum, Momotaj Jahan, et al. "Antimony-Induced Neurobehavioral and Biochemical Perturbations in Mice." Biological Trace Element Research 186, no. 1 (2018): 199–207. http://dx.doi.org/10.1007/s12011-018-1290-5.

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10

Barbosa, Brenna De Sousa, Érika Almeida Praxedes, Mikael Almeida Lima, et al. "Haematological and Biochemical Profile of Balb-c Mice." Acta Scientiae Veterinariae 45, no. 1 (2017): 5. http://dx.doi.org/10.22456/1679-9216.80473.

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Background: Animal models are widely used in scientific research because of the ability to generate information from an organism like everything under a given experimental condition. Hematological and biochemical tests in laboratory animals are essential for the validation of several scientific studies. In addition, it standardizes physiological values for these animals according to their sex, age, lineage, environment, and nutritional status. The present work aims to establish reference values for biochemical and hematological standards in Balb/c mice, for males and females.Materials, Methods & Results: A total of 50 male and female mice were used at reproductive age. The procedures for collecting, processing, and analyzing the samples were standardized. The collected blood samples were immediately transferred to eppendorf tubes containing heparin, and intended for hematological and biochemical evaluation. The hematological evaluation consisted of Red blood cell count (RBC), Leukocyte counts (WBC), Platelet counts (PLT), Hematocrit (HCT), Hemoglobin concentration (HGB), Mean corpuscular volume (MCV), and Mean corpuscular hemoglobin concentration (MCHC). Already the quantified biochemical parameters were: urea, creatinine, alanina aminotransaminase (ALT), aspartato aminotransaminase (AST) and fosfatase alcalina (FAL). The differential leukocyte count was also performed. Hematological results obtained for males and females were: 9.19 ± 3.35 (106/mm³) and 7.3 ± 2.01(106/mm³) of RBC; 35.8 ± 6.7% and 38.44 ± 3.93% of HCT; 11.51 ± 2.17 g/dL and 11.85 ± 1.56 g/dL of HGB; 45.83 ± 15.03 fL and 60.26 ± 18.25 fL of VCM; 31.80 ± 1.15% and 31.88 ± 0.99% of MCHC; and, 5380 ± 1994.21(10³/mm³) and 3564 ± 1071(10³/mm³) of WBC. The platelet counts were 878.92 ± 84.19 and 678.28 ± 227.21, for males and females respectively. And for differential leukocyte counts, for males and females: eosinophils 2.12 ± 1.09% and 2.16 ± 1.71%; monocytes 2.84 ± 1.03% and 2.68 ± 1%; lymphocytes 68 ± 8.36% and 71.76 ± 5.9%; neutrophils 27.04 ± 8.55% and 22.96 ± 5.54%. Basophils were not quantified in the samples. As for the biochemical parameters, values of 54.16 ± 27.8 UI/L and 29.72 ± 4.4 UI/L of ALT; 89.56 ± 47.73 UI/L and 71.32 ± 8.12 UI/L of AST; 3.76 ± 2.08 UI/L and 2.32 ± 0.85 UI/L of FAL; 31.76 ± 21.08 mg/dL and 41.48 ± 13.61 mg/dL of urea; and 0.76 ± 0.18 mg/dL and 0.44 ± 0.11 mg/dL of creatinine.Discussion: The mean corpuscular volume, mean corpuscular hemoglobin concentration, leukocyte, and platelet counts diverged from those found in literature. For the biochemical values, it was observed that creatinine values were different from those exhibited by other authors. Such divergences might be explained by the activity of endocrine organs, such as the production and/or release of activation/differentiation factors, and stress, applied methodology, lineage, or individual variability. In addition, differences in the methodologies applied may be responsible for variations in hematological and biochemical values, requiring the standardization of the equipment and reagents used, as well as the adoption of a range that represents the minimum and maximum values within the normal physiological standard for given mouse lineage. In conclusion, the values presented in the present work are within the variation curve for rodents, and can be used as reference for other studies that use these animals.

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11

Takaori, Kazuo, Shokei Kim, Akiyoshi Fukamizu, et al. "Biochemical characteristics of human renin expressed in transgenic mice." Clinical Science 84, no. 1 (1993): 21–29. http://dx.doi.org/10.1042/cs0840021.

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1. Biochemical properties of human renin expressed in transgenic mice (hRN8-12 mice) carrying the human renin gene (Fukamizu et al. Biochem Biophys Res Commun 1989; 165: 826–32) were examined. The optimum pH of the enzymic activity against human angiotensinogen was 5.5 for both plasma and renal human renin in the hRN8-12 mice. Plasma concentrations of human active and inactive renin in the plasma of hRN8-12 mice were 16.7 ± 2.8 and 79.9 ± 14.0 pmol of angiotensin 1 h−1 ml−1, respectively, thereby indicating that the predominant form of plasma human renin is the inactive form, as is the case in humans. 2. The molecular masses of plasma human active and inactive renin and renal human active renin in the hRN8-12 mice were estimated to be 46kDa, 48kDa and 44kDa, respectively, as determined by h.p.l.c. on G3,000SW. 3. Human renin in the hRN8-12 mouse kidney was bound to a concanavalin A-Sepharose column, and was eluted with α-methyl-d-mannoside, showing that this renin is glycosylated, as is native human renin. 4. Low sodium treatment of the hRN8-12 mice for 2 weeks increased plasma human active renin, renal human renin and renal human renin mRNA levels by 2.6-, 3.8- and 2.8-fold, respectively. Thus, the biosynthesis and secretion of renal human renin in these transgenic mice are obviously stimulated by sodium depletion.

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C Onyishi, Grace, Godwin C Nwosu, and Joseph E Eyo. "In vivo studies on the biochemical indices of Plasmodium berghei infected mice treated with Alstonia boonei leaf and root extracts." African Health Sciences 20, no. 4 (2020): 1698–709. http://dx.doi.org/10.4314/ahs.v20i4.21.

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Background: A study on the biochemical indices of albino mice infected with Plasmodium berghei and treated with Alstonia boonei aqueous and ethanolic extracts was undertaken. Methods: 216 males mice were randomly assigned to six treatment groups each containing six mice for both aqueous and ethanolic extracts experiments. P. berghei NK-65 was inoculated into the mice intraperitoneally and establishment of infection confirmed. Administration of extracts of was done after phytochemical and acute toxicity tests at varying concentrations, for both suppressive and curative tests. Blood samples collected by ocular puncturing were examined for the biochemical indices; ALT, AST, ALP, creatinine and total protein using the standard procedures. Results: A. boonei extracts suppression of P. berghei in mice was comparable to the standard drug. Significantly higher (p<0.05) recovery of mice treated with A. boonei extracts was observed. The biochemical indices examined all had signif- icantly (p<0.05) increased concentration after 7 days post-infection, except for total protein concentration which had no significant increase or decrease due to A. boonei extracts administration. Conclusion: The antiplasmodial potentials of A. boonei leaf and root extracts were dosage and duration-dependent, and have demonstrated satisfactory normalization of altered biochemical indices due to malaria. Keywords: In vivo; anti-malaria; Alstonia boonei; biochemical; Plasmodium berghei; mice.

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13

Zein, Nabila, Enaiat K. Mohamed, and Fatma EL Zahraa El Sayed. "Biochemical Studies of Eucalyptus as an Antitumor in Mice." Biochemistry Letters 11, no. 1 (2016): 115–29. http://dx.doi.org/10.21608/blj.2016.47873.

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14

Lem, J., N. V. Krasnoperova, P. D. Calvert, et al. "Morphological, physiological, and biochemical changes in rhodopsin knockout mice." Proceedings of the National Academy of Sciences 96, no. 2 (1999): 736–41. http://dx.doi.org/10.1073/pnas.96.2.736.

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15

El-Sawi, Nagwa M., Mohamed T. El-Wassimy, and Osama A. Youssef. "BIOCHEMICAL STUDIES OF VERRUCARIN J IN MALE MICE LIVER." Journal of Toxicology: Toxin Reviews 19, no. 3-4 (2000): 265–73. http://dx.doi.org/10.1081/txr-100102323.

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16

Filazi, Ayhan, Meltem Sireli, and Faruk Kalkan. "The influence of amitraz on biochemical parameters in mice." Human & Experimental Toxicology 22, no. 2 (2003): 99–101. http://dx.doi.org/10.1191/0960327103ht339cr.

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In this study, the effect of amitraz on biochemical parameters of mice was studied. Mice were given amitraz by gavage at 15 or 45 mg/kg body weight. Since the drug was diluted with dimethylsulphoxide (DMSO), it was administered to another experimental animal group in order to determine its own effects on biochemical parameters. Following drug administration, 48 hours passed to let hepatic lesions develop and after that 1 mL of blood was taken from each mouse. They were killed by ether euthanasia for histopathological examination. The result of the analyses revealed that amitraz had no effect on serum glucose concentration, whereas DMSO led to a significant decrease in blood sugar concentration. Increase in urea, phosphorous, aspartate transaminase and alanine amino transferase values were observed only in the group given 45 mg/kg body weight amitraz. A decrease in creatinine and alkaline phosphatase concentrations was observed in all groups. No differences were observed in serum calcium and bilirubin concentrations. No pathological changes were detected in the kidneys and livers. It was concluded that, even in asymptomatic amitraz toxicity cases, adverse effects on kidney and liver functions were likely to develop.

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17

Gordon, Irit, Idit Genis, Ettie Grauer, Ephraim Sehayek, and Daniel M. Michaelson. "Biochemical and cognitive studies of apolipoprotein-E-deficient mice." Molecular and chemical neuropathology 28, no. 1-3 (1996): 97–103. http://dx.doi.org/10.1007/bf02815210.

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18

Mita, Takashi, Shunsuke Sashihara, Ikuho Aramaki, Yukiko Fueta, and Hideyasu Hirano. "Unusual biochemical development of genetically seizure-susceptible El mice." Developmental Brain Research 64, no. 1-2 (1991): 27–35. http://dx.doi.org/10.1016/0165-3806(91)90205-w.

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19

Goodrich, Cecilie A., Peter C. Baker, and Gregory P. Bauman. "Biochemical and functional effects of fenfluramine in maturing mice." General Pharmacology: The Vascular System 17, no. 4 (1986): 457–60. http://dx.doi.org/10.1016/0306-3623(86)90192-8.

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20

Liu, Huiting, Linglan Ma, Jinfang Zhao, et al. "Biochemical Toxicity of Nano-anatase TiO2 Particles in Mice." Biological Trace Element Research 129, no. 1-3 (2008): 170–80. http://dx.doi.org/10.1007/s12011-008-8285-6.

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21

Roberts, Nathan W., Jenan Holley-Cuthrell, Magdalis Gonzalez-Vega, Aaron J. Mull, and Ahlke Heydemann. "Biochemical and Functional Comparisons ofmdxandSgcg−/−Muscular Dystrophy Mouse Models." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/131436.

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Mouse models have provided an essential platform to investigate facets of human diseases, from etiology, diagnosis, and prognosis, to potential treatments. Muscular dystrophy (MD) is the most common human genetic disease occurring in approximately 1 in 2500 births. Themdxmouse, which is dystrophin-deficient, has long been used to model this disease. However, this mouse strain displays a rather mild disease course compared to human patients. Themdxmice have been bred to additional genetically engineered mice to worsen the disease. Alternatively, other genes which cause human MD have been genetically disrupted in mice. We are now comparing disease progression from one of these alternative gene disruptions, theγ-sarcoglycan null mouseSgcg−/−on the DBA2/J background, to themdxmouse line. This paper aims to assess the time-course severity of the disease in the mouse models and determine which is best for MD research. TheSgcg−/−mice have a more severe phenotype than themdxmice. Muscle function was assessed by plethysmography and echocardiography. Histologically theSgcg−/−mice displayed increased fibrosis and variable fiber size. By quantitative Evan’s blue dye uptake and hydroxyproline content two key disease determinants, membrane permeability and fibrosis respectively, were also proven worse in theSgcg−/−mice.

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22

Yu, Ping, Nicholas A. Di Prospero, Michael T. Sapko, et al. "Biochemical and Phenotypic Abnormalities in Kynurenine Aminotransferase II-Deficient Mice." Molecular and Cellular Biology 24, no. 16 (2004): 6919–30. http://dx.doi.org/10.1128/mcb.24.16.6919-6930.2004.

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ABSTRACT Kynurenic acid (KYNA) can act as an endogenous modulator of excitatory neurotransmission and has been implicated in the pathogenesis of several neurological and psychiatric diseases. To evaluate its role in the brain, we disrupted the murine gene for kynurenine aminotransferase II (KAT II), the principal enzyme responsible for the synthesis of KYNA in the rat brain. mKat-2−/− mice showed no detectable KAT II mRNA or protein. Total brain KAT activity and KYNA levels were reduced during the first month but returned to normal levels thereafter. In contrast, liver KAT activity and KYNA levels in mKat-2−/− mice were decreased by >90% throughout life, though no hepatic abnormalities were observed histologically. KYNA-associated metabolites kynurenine, 3-hydroxykynurenine, and quinolinic acid were unchanged in the brain and liver of knockout mice. mKat-2−/− mice began to manifest hyperactivity and abnormal motor coordination at 2 weeks of age but were indistinguishable from wild type after 1 month of age. Golgi staining of cortical and striatal neurons revealed enlarged dendritic spines and a significant increase in spine density in 3-week-old mKat-2−/− mice but not in 2-month-old animals. Our results show that gene targeting of mKat-2 in mice leads to early and transitory decreases in brain KAT activity and KYNA levels with commensurate behavioral and neuropathological changes and suggest that compensatory changes or ontogenic expression of another isoform may account for the normalization of KYNA levels in the adult mKat-2−/− brain.

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23

Miller, R. Lance. "Transgenic mice: beyond the knockout." American Journal of Physiology-Renal Physiology 300, no. 2 (2011): F291—F300. http://dx.doi.org/10.1152/ajprenal.00082.2010.

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Transgenic mice have had a tremendous impact on biomedical research. Most researchers are familiar with transgenic mice that carry Cre recombinase (Cre) and how they are used to create conditional knockouts. However, some researchers are less familiar with many of the other types of transgenic mice and their applications. For example, transgenic mice can be used to study biochemical and molecular pathways in primary cultures and cell suspensions derived from transgenic mice, cell-cell interactions using multiple fluorescent proteins in the same mouse, and the cell cycle in real time and in the whole animal, and they can be used to perform deep tissue imaging in the whole animal, follow cell lineage during development and disease, and isolate large quantities of a pure cell type directly from organs. These novel transgenic mice and their applications provide the means for studying of molecular and biochemical events in the whole animal that was previously limited to cell cultures. In conclusion, transgenic mice are not just for generating knockouts.

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24

Yuan, Xiaohong, Shu Yang, Wen Li, et al. "Construction of fibronectin conditional gene knock-out mice and the effect of fibronectin gene knockout on hematopoietic, biochemical and immune parameters in mice." PeerJ 8 (October 30, 2020): e10224. http://dx.doi.org/10.7717/peerj.10224.

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Fibronectin (FN) is a multi-functional glycoprotein that primarily acts as a cell adhesion molecule and tethers cells to the extra cellular matrix. In order to clarify the effect of FN deficiency on hematopoiesis, biochemical and immune parameters in mice. We constructed a tamoxifen-induced conditional (cre-loxp system) fibronectin knock-out (FnKO) mouse model on a C57BL/6 background, and monitored their behavior, fertility, histological, hematopoietic, biochemical and immunological indices. We found that the Fn KO mice had reduced fertility, high platelet counts, smaller bone marrow megakaryocytes and looser attachment between the hepatocyte and vascular endothelial junctions compared to the wild type (WT) mice. In contrast, the behavior, hematological counts, serum biochemical indices and vital organ histology were similar in both Fn KO and WT mice. This model will greatly help in elucidating the role of FN in immune-related diseases in future.

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25

Jeong, Seong-Wook, Yong-Soo Han, and Heung-Jai Park. "Risk Assessment of Nitrogen Dioxide for Hematological and Biochemical Parameter in Mice." Journal of Environmental Science International 16, no. 5 (2007): 665–70. http://dx.doi.org/10.5322/jes.2007.16.5.665.

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26

Yamate, J., M. Tajima, Y. Maruyama, and S. Kudow. "Observations on soft tissue calcification in DBA/2NCrj mice in comparison with CRJ:CD-1 mice." Laboratory Animals 21, no. 4 (1987): 289–98. http://dx.doi.org/10.1258/002367787781363309.

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Male and female DBA/2NCrj (DBA/2) mice 3, 4, 5 and 10 weeks old were examined biochemically and pathologically and the results obtained were compared with those for CRJ:CD-1 (ICR) mice of the same age. The plasma levels of glucose, triglyceride and total cholesterol tended to be lower in DBA/2 mice than in ICR mice but the levels of non-esterified fatty acid, calcium and inorganic phosphorus were almost the same in the two strains. The mean body weight of DBA/2 mice was significantly lower than that of ICR mice at each examination, and the relative weights of the hearts of male and female DBA/2 mice were significantly greater than those of male and female ICR mice. Cardiac calcinosis, tongue calcification and corneal degeneration occurred exclusively in DBA/2 mice with incidences of 30%-100%. The incidence and severity of these lesions increased with age but no sex differences were seen. It was difficult to relate differences in biochemical features of the two strains with pathological findings obtained in the DBA/2 mice. The numbers of cells secreting adrenocorticotropic hormone in the pituitary glands were significantly greater in male and female DBA/2 mice than in ICR mice, suggesting a higher secretion of corticosteroids in the former strain.

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27

Brun, Alejandro, Alfonso Gutiérrez-Adán, Joaquín Castilla, et al. "Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats." Journal of General Virology 88, no. 6 (2007): 1842–49. http://dx.doi.org/10.1099/vir.0.82568-0.

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In this work, transgenic (Tg) mice were generated expressing a bovine prion protein containing five octarepeats (BoPrP5OR-Tg). After intracerebral inoculation of bovine spongiform encephalopathy (BSE) inoculum, these mice suffered a BSE-like neuropathology but survived longer compared with homologous Tg mice expressing similar levels of a six octarepeat BoPrP protein (BoPrP6OR-Tg). De novo-generated five octarepeat (5OR) PrPSc showed no biochemical differences from 6OR-PrPSc, and the proteinase K-resistant core (PrPres) was biochemically indistinguishable from the 6OR counterpart. Lower susceptibility to BSE is suggested for BoPrP5OR-Tg mice, as they were not as efficient at replicating BSE prions from the same natural source inoculum as BoPrP6OR-Tg mice expressing similar PrPC levels. These results raise the possibility of selecting cattle breeds bearing the 5OR Prnp allele that are less susceptible to prion infection.

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28

Choi, Seong-Kwan. "Biochemical Changes in the Tissue of Mice Irradiated with LINAC." Journal of the Korea Contents Association 16, no. 3 (2016): 661–66. http://dx.doi.org/10.5392/jkca.2016.16.03.661.

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29

M. Al-Amoudi, Wael. "Haematological and Biochemical Effects of Metalaxyl Fungicide on Albino Mice." American Journal of Biochemistry 2, no. 5 (2012): 62–66. http://dx.doi.org/10.5923/j.ajb.20120205.03.

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30

Salahuddin, M., H. Akhter, S. Akter, MA Miah, and N. Ahmad. "Effects of probiotics on haematology and biochemical parameters in mice." Bangladesh Veterinarian 30, no. 1 (2013): 20–24. http://dx.doi.org/10.3329/bvet.v30i1.16281.

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Probiotic organisms are live microorganisms thought to be beneficial to the host. To know the effect of probiotic supplemented food on haemato-biochemical parameters in mice, a total of 20 two-month-old Swiss Albino mice were randomly divided into four equal groups. Group A was control, fed commercial mouse pellets, and others were treated with 5 g (group B), 10 g (group C) and 20 g (group D) probiotics (curd), respectively, in mouse pellets for 45 days. Total erythrocyte count and haemoglobin concentration were significantly (P<0.01) higher in treated group than in controls. Total serum cholesterol, triglyceride, high density lipoprotein and low density lipoprotein values decreased significantly (P<0.01) in treated groups. Serum uric acid value was significantly higher (P<0.01) in treated groups. It is suggested that probiotics help improve haematology and lipid profile but not kidney function. DOI: http://dx.doi.org/10.3329/bvet.v30i1.16281 Bangl. vet. 2013. Vol. 30, No. 1, 20-24

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Santos, D. B., D. Colle, E. L. G. Moreira, et al. "Probucol mitigates streptozotocin-induced cognitive and biochemical changes in mice." Neuroscience 284 (January 2015): 590–600. http://dx.doi.org/10.1016/j.neuroscience.2014.10.019.

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Miller, Richard A., Scott B. Berger, David T. Burke, et al. "T cells in aging mice: genetic, developmental, and biochemical analyses." Immunological Reviews 205, no. 1 (2005): 94–103. http://dx.doi.org/10.1111/j.0105-2896.2005.00254.x.

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Brotto, Marco A. P., Mauro T. Marrelli, Leticia S. Brotto, Marcelo Jacobs-Lorena, and Thomas M. Nosek. "Functional and biochemical modifications in skeletal muscles from malarial mice." Experimental Physiology 90, no. 3 (2005): 417–25. http://dx.doi.org/10.1113/expphysiol.2004.028316.

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Mezhzherin, S. V., and E. V. Kotenkova. "Biochemical systematics of House mice from the central Palearctic region." Journal of Zoological Systematics and Evolutionary Research 30, no. 3 (1992): 180–88. http://dx.doi.org/10.1111/j.1439-0469.1992.tb00167.x.

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35

Spooren, W. P. J. M., C. Wiessner, R. Waldmeier, and C. Gentsch. "BEHAVIOURAL AND BIOCHEMICAL CHARACTERIZATION OF MPTP TREATED C57BL/6 MICE." Behavioural Pharmacology 9, Supplement (1998): S83. http://dx.doi.org/10.1097/00008877-199808001-00194.

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Spooren, W. P. J. M., C. Wiessner, R. Waldmeier, and C. Gentsch. "BEHAVIOURAL AND BIOCHEMICAL CHARACTERIZATION OF MPTP TREATED C57BL/6 MICE." Behavioural Pharmacology 9, no. 1 (1998): S83. http://dx.doi.org/10.1097/00008877-199812001-00194.

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Spooren, W. P. J. M., C. Wiessner, R. Waldmeier, and C. Gentsch. "BEHAVIOURAL AND BIOCHEMICAL CHARACTERIZATION OF MPTP TREATED C57BL/6 MICE." Behavioural Pharmacology 9, no. 1 (1998): S83. http://dx.doi.org/10.1097/00008877-199808000-00194.

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Dominguez, Diana, Jos Tournoy, Dieter Hartmann, et al. "Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice." Journal of Biological Chemistry 280, no. 35 (2005): 30797–806. http://dx.doi.org/10.1074/jbc.m505249200.

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39

Vogel, Silke, Roseann Piantedosi, Sheila M. O'Byrne, et al. "Retinol-Binding Protein-Deficient Mice: Biochemical Basis for Impaired Vision†." Biochemistry 41, no. 51 (2002): 15360–68. http://dx.doi.org/10.1021/bi0268551.

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40

Kanyuka, O. P., Ye Z. Filyak, S. V. Afanasyev, and N. O. Sybirna. "Some blood biochemical indices of mice with pttg gene knockout." Studia Biologica 5, no. 3 (2011): 41–48. http://dx.doi.org/10.30970/sbi.0503.178.

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Adamson, I. Y. R., H. Prieditis, and C. Hedgecock. "Pulmonary response of mice to fiberglass: Cytokinetic and biochemical studies." Journal of Toxicology and Environmental Health 46, no. 4 (1995): 411–24. http://dx.doi.org/10.1080/15287399509532046.

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42

Weihmuller, F. B., M. Hadjiconstantinou, and J. P. Bruno. "Dissociation between biochemical and behavioral recovery in MPTP-treated mice." Pharmacology Biochemistry and Behavior 34, no. 1 (1989): 113–17. http://dx.doi.org/10.1016/0091-3057(89)90362-6.

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Prohaska, Joseph R., and Omelan A. Lukasewycz. "Biochemical and immunological changes in mice following postweaning copper deficiency." Biological Trace Element Research 22, no. 1 (1989): 101–12. http://dx.doi.org/10.1007/bf02917420.

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Al-Bekairi, A. M., S. Qureshi, M. A. Chaudhry, D. R. Krishna, and A. H. Shah. "Mitodepressive, clastogenic and biochemical effects of (+)-usnic acid in mice." Journal of Ethnopharmacology 33, no. 3 (1991): 217–20. http://dx.doi.org/10.1016/0378-8741(91)90079-s.

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El-Ashmawy, Nahla E., Hoda A. El-Bahrawy, Maha M. Shamloula, and Ola A. El-Feky. "Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice." Tumor Biology 35, no. 6 (2014): 5459–66. http://dx.doi.org/10.1007/s13277-014-1714-6.

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Miller, Richard A. "Biochemical and genetic analyses of T cell aging in mice." Springer Seminars in Immunopathology 24, no. 1 (2002): 61–73. http://dx.doi.org/10.1007/s00281-001-0097-0.

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Berezkin, M. V., Yu N. Gratsinskii, V. F. Kudinova, and T. S. Chusovkova. "Seasonal and circadian rhythms of blood biochemical parameters in mice." Bulletin of Experimental Biology and Medicine 104, no. 6 (1987): 1641–44. http://dx.doi.org/10.1007/bf00835984.

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George, Jeneesha, A. Thabitha, N. Vignesh, et al. "Antiskin Cancer and Antioxidant Activities of Formulated Agar from Brown Seaweed Laminaria digitata (Hudson) in Dimethyl Benzanthracene-Induced Swiss Albino Mice." International Journal of Polymer Science 2021 (June 15, 2021): 1–12. http://dx.doi.org/10.1155/2021/9930777.

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Abstract:

This study explores the antiskin cancer effect of formulated agar (FA) from Laminaria digitata on dimethyl benzanthracene- (DMBA-) induced skin cancer mice. The agar was extracted and formulated (emulgel), and FA was biochemically characterized. The in vitro cytotoxicity of FA was tested using NTT 3T3 mice fibroblast cells. The mice were divided into 5 groups: group 1 served as control mice, group 2 mice were considered as DMBA-induced cancer control, group 3 mice were FA pretreated (low dose) + DMBA-induced mice, group 4 mice were FA pretreated (high dose) + DMBA-induced mice, and group 5 were positive control + DMBA-induced mice. The behaviour and biochemical markers of cancer were significantly decreased in group 2 (DMBA-induced) mice, which were brought to near normalcy by FA pretreated mice (groups 3 and 4). The levels of p53 and keratin were significantly elevated in group 2 mice and these levels were decreased in 3 and 4 mice as well. The histopathological examination of DMBA-induced mice was shown degenerated cervical patches in the skin, cirrhosis in liver, oedema in the renal tissue, and swollen and damage in cardiac tissue, which were reduced for the mice applied with FA. This confirms that FA pretreatment offered potential antiskin cancer property.

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SCHWAHN, Bernd C., Maurice D. LARYEA, Zhoutao CHEN, et al. "Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency." Biochemical Journal 382, no. 3 (2004): 831–40. http://dx.doi.org/10.1042/bj20030822.

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MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine. A severe deficiency of MTHFR results in hyperhomocysteinaemia and homocystinuria. Betaine supplementation has proven effective in ameliorating the biochemical abnormalities and the clinical course in patients with this deficiency. Mice with a complete knockout of MTHFR serve as a good animal model for homocystinuria; early postnatal death of these mice is common, as with some neonates with low residual MTHFR activity. We attempted to rescue Mthfr−/− mice from postnatal death by betaine supplementation to their mothers throughout pregnancy and lactation. Betaine decreased the mortality of Mthfr−/− mice from 83% to 26% and significantly improved somatic development from postnatal day 1, compared with Mthfr−/− mice from unsupplemented dams. Biochemical evaluations demonstrated higher availability of betaine in suckling pups, decreased accumulation of homocysteine, and decreased flux through the trans-sulphuration pathway in liver and brain of Mthfr−/− pups from betaine-supplemented dams. We observed disturbances in proliferation and differentiation in the cerebellum and hippocampus in the knockout mice; these changes were ameliorated by betaine supplementation. The dramatic effects of betaine on survival and growth, and the partial reversibility of the biochemical and developmental anomalies in the brains of MTHFR-deficient mice, emphasize an important role for choline and betaine depletion in the pathogenesis of homocystinuria due to MTHFR deficiency.

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Raymond Bess Bila, Germain Sotoing Taiwe, David Denis Feugaing Sofeu, et al. "Prophylactic antimalarial effects of Cymbopogon citratus (DC.) Stapf (Poaceae) in a mouse model of Plasmodium berghei ANKA infection: normalisation of haematological and serum biochemical status." GSC Biological and Pharmaceutical Sciences 15, no. 1 (2021): 05–017. http://dx.doi.org/10.30574/gscbps.2021.15.1.0084.

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Ethnopharmacological relevance: Cymbopogon citratus (DC.) Stapf (Poaceae) is a medicinal plant known for its antimalarial, antipyretic and antifatigue activities in Cameroonian folk medicine. Aim of the study: The aim of this work was to evaluate the prophylactic antimalarial effects of the decoction prepared from the leaves of Cymbopogon citratus on Plasmodium berghei ANKA infection in mice and investigate its action on haematological and serum biochemical status. Materials and methods: Swiss mice were treated with Cymbopogon citratus leaf decoction (25, 50, 100 and 200 mg/kg) and later inoculated with Plasmodium berghei ANKA. The prophylactic antimalarial activity of the decoction was evaluated by determining the parasitaemia, percentage chemosuppression, body weight, body temperature, food and water intake in pretreated parasitised mice. The possible ameliorative effects of the decoction on malaria associated haematological and serum biochemical changes were also assessed. Results: The decoction exhibited a prophylactic activity of 85.32% and its chemotherapeutic effects ranged from 56.88 – 85.32% with maximum effect observed at the highest experimental dose. It significantly inhibited parasitaemia (P < 0.001) compared to the negative control group. Interestingly, treatment of parasitised mice with the decoction significantly restored the malaria modified haematological and biochemical status compared with distilled water-treated parasitised mice. Conclusion: The results of this prophylactic assay indicated that Cymbopogon citratus decoction has antimalarial effects and normalised haematological and serum biochemical aberrations generated by malaria. Hence, Cymbopogon citratus represents a promising source of new antimalarial agents.

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