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Dissertations / Theses on the topic 'Biochemical model'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Khoshnaw, Sarbaz Hamza Abdullah. "Model reductions in biochemical reaction networks." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32442.

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Many complex kinetic models in the field of biochemical reactions contain a large number of species and reactions. These models often require a huge array of computational tools to analyse. Techniques of model reduction, which arise in various theoretical and practical applications in systems biology, represent key critical elements (variables and parameters) and substructures of the original system. This thesis aims to study methods of model reduction for biochemical reaction networks. It has three goals related to techniques of model reduction. The primary goal provides analytical approximat

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2

Hughes, Helen Margaret. "Model systems for studying the biochemical effects of hepatotoxins." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254495.

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3

Wu, Zujian. "A generic approach to behaviour-driven biochemical model construction." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/7413.

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Modelling of biochemical systems has received considerable attention over the last decade from bioengineering, biochemistry, computer science, and mathematics. This thesis investigates the applications of computational techniques to computational systems biology, for the construction of biochemical models in terms of topology and kinetic rates. Due to the complexity of biochemical systems, it is natural to construct models representing the biochemical systems incrementally in a piecewise manner. Syntax and semantics of two patterns are defined for the instantiation of components which are exte

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4

Wu, Jialiang. "Hybrid modeling and analysis of multiscale biochemical reaction networks." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/47723.

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This dissertation addresses the development of integrative modeling strategies capable of combining deterministic and stochastic, discrete and continuous, as well as multi-scale features. The first set of studies combines the purely deterministic modeling methodology of Biochemical Systems Theory (BST) with a hybrid approach, using Functional Petri Nets, which permits the account of discrete features or events, stochasticity, and different types of delays. The efficiency and significance of this combination is demonstrated with several examples, including generic biochemical networks with feed

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5

Trumble, Troy Neal. "Early osteoarthritic changes in a canine cranial cruciate deficient model." Access citation, abstract and download form; downloadable file 15.41 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131703.

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6

Quaiser, Tom [Verfasser]. "Data- and model-based identification of biochemical processes / Tom Quaiser." Aachen : Shaker, 2012. http://d-nb.info/1069045845/34.

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7

Gibb, Jason Ocean Telford. "NMR studies on the effects of model pollutants in selected invertebrate species." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268053.

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8

Banks, Christopher Jon. "Spatio-temporal logic for the analysis of biochemical models." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/10512.

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Process algebra, formal specification, and model checking are all well studied techniques in the analysis of concurrent computer systems. More recently these techniques have been applied to the analysis of biochemical systems which, at an abstract level, have similar patterns of behaviour to concurrent processes. Process algebraic models and temporal logic specifications, along with their associated model-checking techniques, have been used to analyse biochemical systems. In this thesis we develop a spatio-temporal logic, the Logic of Behaviour in Context (LBC), for the analysis of biochemical

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9

Reid, Cherith Norma. "Biochemical basis of interspecific cell signalling : an invertebrate and vertebrate model." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326448.

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10

Mintz, Christina. "Predicting Chemical and Biochemical Properties Using the Abraham General Solvation Model." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc28373/.

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Several studies were done to illustrate the versatillity of the Abraham model in mathematically describing the various solute-solvent interactions found in a wide range of different chemical and biological systems. The first study focused on using the solvation model to construct mathematical correlations describing the minimum inhibitory concentration of organic compounds for growth inhibition towards the three bacterial strains Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus. The next several studies expand the practicallity of the Abraham model by predicting fr

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11

Leising, Sophie. "Nonlinear controller synthesis for complex chemical and biochemical reaction systems." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-050205-152657/.

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Thesis (M.S.) -- Worcester Polytechnic Institute.<br>Keywords: model predictive control; discrete-time model; continuous-time model; nonlinear systems; Lyapunov design. Includes bibliographical references (p. 99-102).

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12

Chen, Minghan. "Stochastic Modeling and Simulation of Multiscale Biochemical Systems." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/90898.

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Numerous challenges arise in modeling and simulation as biochemical networks are discovered with increasing complexities and unknown mechanisms. With the improvement in experimental techniques, biologists are able to quantify genes and proteins and their dynamics in a single cell, which calls for quantitative stochastic models for gene and protein networks at cellular levels that match well with the data and account for cellular noise. This dissertation studies a stochastic spatiotemporal model of the Caulobacter crescentus cell cycle. A two-dimensional model based on a Turing mechanism is in

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13

Ngai, H. Y. Heidi. "Proteomics analysis of potential biomarkers and pathogenic mechanisms of membranous nephropathy in a rat model of passive Heymann nephritis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38827372.

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14

Pu, Yang. "The Art of Modeling and Simulation of Multiscale Biochemical Systems." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/52347.

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In this thesis we study modeling and simulation approaches for multiscale biochemical systems. The thesis addresses both modeling methods and simulation strategies. In the first part, we propose modeling methods to study the behavior of the insulin secretion pathway. We first expand the single cell model proposed by Bertram et. al. to model multiple cells. Synchronization among multiple cells is observed. Then an unhealthy cell model is proposed to study the insulin secretion failure caused by weakening of mitochondria function. By studying the interaction between the healthy and unhealthy cel

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15

Naswa, Sudhir. "Representation of Biochemical Pathway Models : Issues relating conversion of model representation from SBML to a commercial tool." Thesis, University of Skövde, School of Humanities and Informatics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-28.

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<p>Background: Computational simulation of complex biological networks lies at the heart of systems biology since it can confirm the conclusions drawn by experimental studies of biological networks and guide researchers to produce fresh hypotheses for further experimental validation. Since this iterative process helps in development of more realistic system models a variety of computational tools have been developed. In the absence of a common format for representation of models these tools were developed in different formats. As a result these tools became unable to exchange models amongst th

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16

Hughes, Alistair Paul. "The accuracy of linear flux models in predicting reaction rate profiles in a model biochemical reaction system." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/9116.

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Includes bibliographical references<br>Metabolic flux analysis is commonly used in the modelling of biochemical reactions. The use of MFA models has gained large amounts of interest due to the simplicity of the computational procedures required for the model, and the exclusion of difficult to measure intracellular reaction data. There are many examples of the use of MFA models in literature studies in a number of applications, ranging from the medical industry through to the development of novel biochemical processes. Little to no mention is provided in literature studies regarding the applica

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Kunsevi-Kilola, Carine. "The effect of Rooibos on trace elements absorption and biochemical parameters-Amurine model." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/1463.

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Thesis submitted in fulfillment of the requirements for the degree Master Technologiae: Biomedical Technology In the Faculty of Health and Wellness Sciences At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY 2014<br>Over the past few decades, it has been shown that various critical diseases including heart disease, cancer, and diabetes associated with free radical generation and low endogenous antioxidant capacity, lead to oxidative stress and cell injury. In recent years, numerous studies have also reported that antioxidants, present in various beverages, vegetables and some foods have attracted

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18

Daruwalla, Anahita. "Understanding Carotenoid and Retinoid Biochemical Diversity using Novel Archaeal and Eukaryotic Model Systems." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1626709424672807.

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Ngai, H. Y. Heidi, and 魏凱怡. "Proteomics analysis of potential biomarkers and pathogenic mechanisms of membranous nephropathy in a rat model of passive Heymann nephritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38827372.

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Kunsevi-Kilola, Carine. "The effect of Rooibos on trace elements absorption and biochemical parameters : a murine model." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/2248.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2014.<br>Over the past few decades, it has been shown that various critical diseases including heart disease, cancer, and diabetes associated with free radical generation and low endogenous antioxidant capacity, lead to oxidative stress and cell injury. In recent years, numerous studies have also reported that antioxidants, present in various beverages, vegetables and some foods have attracted a significant research interest due to their potential benefits to human health. However, epidemiological evidence sh

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21

Jakovljevic, Ivona [Verfasser], Friedemann [Akademischer Betreuer] Kaiser, and Barbara [Akademischer Betreuer] Drossel. "Model for spatiotemporal organization of biochemical circadian clocks / Ivona Jakovljevic. Betreuer: Friedemann Kaiser ; Barbara Drossel." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2011. http://d-nb.info/1105562344/34.

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22

Chen, Zhoutao 1972. "A mouse model for methylenetetrahydrofolate reductase deficiency and biochemical studies of the recombinant human enzyme /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37878.

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Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke. Nutritional and/or genetic disruptions in homocysteine metabolism can cause hyperhomocysteinemia. Mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the 677C → T mutation in the MTHFR gene is the most common genetic cause of hyperhomocysteinemia. The 677C → T variant is associated with an increased risk for neural tube defects, pregnancy complications, schizophrenia and Down syndrome, and with a decreased risk for colon cancer and leukemia. This variant is also a potential risk factor for vas

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23

Paik, Jisun. "CIS-retinol dehydrogenase : characterization and biochemical analysis of 9-cis-retinol metabolism in two model systems /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6600.

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24

Martín, Sómer Ana. "Gas-phase reactivity of Lewis adducts and model biochemical systems : quantum chemistry and molecular dynamics perspectives." Thesis, Evry-Val d'Essonne, 2014. http://www.theses.fr/2014EVRY0057/document.

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La réactivité à la phase gazeuse, ou réactivité intrinsèque, a une grande importance puisque l’absence d’interactions avec un solvant peut donner lieu à une réactivité très diffèrent donc, nous permettant d’avoir une meilleure connaissance des propriétés moléculaires. Avec l’émergence en 1900 de nouvelles techniques expérimentales, plus précisément des techniques pour ioniser plus doucement, la chimie des ions en phase gazeuse s’est développée significativement et a supposé en changement dans l’idée de la réactivité chimique. Cet manuscrit est divisé en deux parties chacune d’elles concernant

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25

Sapotnick, Alexander [Verfasser]. "On a finite element approach for the solution of a mechanically stimulated biochemical fracture healing model / Alexander Sapotnick." Hannover : Technische Informationsbibliothek (TIB), 2015. http://d-nb.info/1129628175/34.

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26

Sáez, Avaria Claudio. "Physiological, biochemical, and molecular responses to copper stress in different strains of the model brown alga Ectocarpus siliculosus." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3008.

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Brown algae have been the focus of metal ecotoxicology research for over 60 years, mainly because of their high metal accumulation capacity and reputed resistance. Now that Ectocarpus siliculosus has been positioned as a model for the study of brown algae, and that the genome has been recently sequenced and annotated, new lines of research have been made possible on these ecologically and economically important organisms, including the field of ecotoxicology. Several strains of E. siliculosus have been collected and isolated from locations around the world, thus providing the opportunity to st

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27

Zhou, Shanshan. "QUARTZ CRYSTAL MICROBALANCE INVESTIGATION OF CELLULOSOME ACTIVITY FROM CLOSTRIDIUM THERMOCELLUM ON MODEL CELLULOSE FILMS." UKnowledge, 2014. http://uknowledge.uky.edu/cme_etds/31.

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The cost of deconstructing cellulose into soluble sugars is a key impediment to the commercial production of lignocellulosic biofuels. The use of the quartz crystal microbalance (QCM) to investigate reaction variables critical to enzymatic cellulose hydrolysis is investigated here, extending previous studies of fungal cellulase activity for the first time to whole cell cellulases. Specifically, the activity of the cellulases of Clostridium thermocellum, which are in the form of cellulosomes, was investigated. To clearly differentiate the activity of free cellulosome and cell-bound cellulosome,

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28

Alinde, Olatogni Berenice Lidwine. "Effects of red palm oil-supplementation on oxidative stress biomarkers in an experimental rat model." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/2257.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2012.<br>Oxidative stress, in recent times appears to be a major underlying risk factor in the occurrence of various diseases such as cardiovascular disease (CVD) and ischemic heart disease (IHD). During oxidative stress, there is an imbalance between the production of reactive oxygen species (ROS) and antioxidant defence mechanisms in favour of ROS. This results in severe cellular damages in the heart, vascular membranes and other organs. Potential benefits of dietary supplements as one of the major quenchin

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Moore, Leah Kathryn. "Neuronal viability and biochemical alterations after mechanical stretch injury: ban in vitro model of traumatic brain injury-induced neourodegeneration." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5362.

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Niu, Zhuolu [Verfasser], and Martin [Akademischer Betreuer] Biel. "Biochemical and functional analysis of a genetic mouse model with altered HCN channel expression / Zhuolu Niu ; Betreuer: Martin Biel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/113104052X/34.

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31

Hurter, Etienne. "Biochemical and physiological changes associated with estrogenic activity in Xenopus laevis : a model for the detection of endocrine disruption." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53309.

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Dissertation (PhD)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: Concern has increased that widespread adverse effects are occurring in humans and wildlife populations as a result of exposure to environmental chemicals (mostly man-made) that disrupt the normal functioning of the endocrine system. Many pharmaceutical, agricultural and industrial chemicals, acting as endocrine modulating compounds (EDCs), have been detected in an accumulated form in food, in drinking water and in the environment. Although the levels of these chemicals can be measured analytically, it is important

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Sequeira, Suzanne Simone. "'1 NMR spectroscopic investigations into the metabolism and biochemical effects of model drugs and enzyme inducers in the rat." Thesis, Birkbeck (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342211.

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33

Moore, Leah Kathryn. "Neuronal viability and biochemical alterations after mechanical stretch injury an in vitro model of traumatic brain injury-induced neourodegeneration /." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180116/unrestricted/moore%5Fleah%5Fk%5F200312%5Fms.pdf.

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Jha, Sumit Kumar. "Model Validation and Discovery for Complex Stochastic Systems." Research Showcase @ CMU, 2010. http://repository.cmu.edu/dissertations/10.

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In this thesis, we study two fundamental problems that arise in the modeling of stochastic systems: (i) Validation of stochastic models against behavioral specifications such as temporal logics, and (ii) Discovery of kinetic parameters of stochastic biochemical models from behavioral specifications. We present a new Bayesian algorithm for Statistical Model Checking of stochastic systems based on a sequential version of Jeffreys’ Bayes Factor test. We argue that the Bayesian approach is more suited for application do- mains like systems biology modeling, where distributions on nuisance paramete

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Bermúdez, Mei-Ling. "Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126.

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Tokimatsu, Toshiaki. "Biochemical Roles of Oxalic Acid in Wood Decay Model Systems and Characteristics of a New Oxalic Acid Producing Enzyme Glyoxylate Dehydrogenase." Kyoto University, 1999. http://hdl.handle.net/2433/182430.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第7591号<br>農博第1030号<br>新制||農||773(附属図書館)<br>学位論文||H11||N3226(農学部図書室)<br>UT51-99-D208<br>京都大学大学院農学研究科林産工学専攻<br>(主査)教授島田幹夫, 教授桒原正章, 教授中坪文明<br>学位規則第4条第1項該当

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Pfeiffer, Brent J. "Role of Proa(2)I collagen chains and collagen crosslinking in thoracic aortic biochemical integrity during aging using the OIM mouse model." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4397.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>Title from title screen of research.pdf file (viewed on December 22, 2006). The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2006" Includes bibliographical references.

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Petrides, Andreas. "Advances in the stochastic and deterministic analysis of multistable biochemical networks." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279059.

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This dissertation is concerned with the potential multistability of protein concentrations in the cell that can arise in biochemical networks. That is, situations where one, or a family of, proteins may sit at one of two or more different steady state concentrations in otherwise identical cells, and in spite of them being in the same environment. Models of multisite protein phosphorylation have shown that this mechanism is able to exhibit unlimited multistability. Nevertheless, these models have not considered enzyme docking, the binding of the enzymes to one or more substrate docking sites, w

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Schleissing, Mary Rucker. "Biochemical and functional analysis after in utero delivery of recombinant adeno-associated virus to a mouse model of glycogen storage disease type II." [Gainesville, Fla.] : University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE0000603.

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Lane, Emma Louise. "A behavioural and biochemical evaluation of the momoamine uptake inhibitor BTS 73 398 in the 6-hydroxydopamine lesioned rat model of Parkinson's disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411513.

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Hernandez, Gabriella Veronica, Victoria Alice Smith, Morgan Coffin, et al. "Development of a Pediatric Model of Nafld in Neonatal Iberian Pigs." DigitalCommons@CalPoly, 2019. https://digitalcommons.calpoly.edu/theses/2097.

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The prevalence of non-alcoholic fatty liver disease (NAFLD) in children has increased over the past decades, creating a need for animal models that recapitulate the features of the pediatric disease. Iberian pigs have a leptin-resistant phenotype characterized by hyperleptinemia, hyperphagia, and extreme adipogenesis. We hypothesized that neonatal Iberian pigs fed a high fat high-fructose (HFF) diet will develop a pattern of liver injury resembling pediatric NAFLD. In addition, we sought to determine if a mixture of probiotics would prevent the disease. Animals were fed 1 of 4 diets containing

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Pinart, Gilberga Mariona. "Time course of biochemical, biomechanical, and histological changes for the assesment of inflammation and remodelling in a bleomycin-induced murine model of lung injury." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/1140.

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Las enfermedades pulmonares intersticiales difusas (EPID), constituyen un grupo variado de trastornos inflamatorios difusos de las vías aéreas inferiores causadas por inflamación, fibrosis (cicatritzación) de las paredes alveolares y grosor del espacio intersticial. Como muchas de estas EPID dan lugar a la formación de fibrosis, también se las llama fibrosis pulmonar (FP). Tanto la fisiopatología de la enfermedad como los mecanismos bioquímicos que se desencadenan son poco conocidos. La lesión pulmonar inducida por fármacos como la bleomicina, es heterogénea y rápida en su inicio, con una fase

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Ly, Philip Tuan Thanh. "In vitro analysis of the biochemical pathways activated by cholesteryl glucoside in a motor neuron hybrid model of amyotrophic lateral sclerosis-parkinsonism dementia complex." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31979.

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Steryl glycosides are a family of compounds commonly found in the environment with unclear biological roles. Cycad seeds, a dietary link to the etiology of the Guamanian amyotrophic lateral sclerosis-Parkinsonism dementia complex (ALS-PDC) have an abundant amount of steryl glycosides. Previously, our laboratory demonstrated that several members of the cycad-derived steryl glycosides have toxic properties. Cholesteryl glucosides (CG), a variant form of the cycad-derived steryl glycosides have been found to induce cell death in primary rat cortical neurons. However, other groups have demon

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Bou, Khalil Maroun. "Elucidation of the biochemical significance of GMb1 ganglioside in model membranes of perdeuterated 1,2-dimyristoyl-L-[alpha]-phosphatidylcholine : a Fourier Transform Infrared spectroscopic investigation." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8864.

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The monosialoganglioside GM1 is an anionic glycosphingolipid found ubiquitously in the plasma membrane of mammalian cells. Although its exact normal biological function(s) and physical properties are unknown, it is speculated that GM1 may play a role in calcium transport and synaptic transmission in neural tissues. Fourier Transform Infrared (FTIR) spectroscopy was employed to test the model of bovine brain GM1 ganglioside incorporated into perdeuterated dimyristoylphosphatidylcholine (DMPCd54) multilamellar dispersions. The interaction of Ca 2+ ions with the mixed DMPCd54/GM1 bilayers and its

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Hoffman, Jared D. "THE PREBIOTIC INULIN BENEFICIALLY MODULATES THE GUT-BRAIN AXIS BY ENHANCING METABOLISM IN AN APOE4 MOUSE MODEL." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/24.

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Alzheimer’s disease (AD) is the most common form of dementia and a growing disease burden that has seen pharmacological interventions primarily fail. Instead, it has been suggested that preventative measures such as a healthy diet may be the best way in preventing AD. Prebiotics are one such potential measure and are fermented into metabolites by the gut microbiota and acting as gut-brain axis components, beneficially impact the brain. However, the impact of prebiotics in AD prevention is unknown. Here we show that the prebiotic inulin increased multiple gut-brain axis components such as scyll

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Bou, Khalil Maroun. "Elucidation of the biochemical significance of GM¦1 ganglioside in model membranes of perdeuterated 1,2-dimyristoyl-L-Ã-phosphatidylcholine, a Fourier transform infrared spectroscopic investigation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ48138.pdf.

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Mélykúti, Bence. "Theoretical advances in the modelling and interrogation of biochemical reaction systems : alternative formulations of the chemical Langevin equation and optimal experiment design for model discrimination." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d368c04c-b611-41b2-8866-cde16b283b0d.

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This thesis is concerned with methodologies for the accurate quantitative modelling of molecular biological systems. The first part is devoted to the chemical Langevin equation (CLE), a stochastic differential equation driven by a multidimensional Wiener process. The CLE is an approximation to the standard discrete Markov jump process model of chemical reaction kinetics. It is valid in the regime where molecular populations are abundant enough to assume their concentrations change continuously, but stochastic fluctuations still play a major role. We observe that the CLE is not a single equatio

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Yan, Qiang. "Metabolic Engineering of Serratia marcescens." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5348.

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The potential value of the chitin biomass (e.g. food waste) is recently considered being ignored by landfill. Chitin can be a potential cheap carbon source for converting into value-added chemicals by microorganisms. Serratia marcescens is a chitinolytic bacterium that harbors endogenous chitinase systems. With goals of characterzing S. marcescens chitinolytic capabilities and applying S. marcescens to chemical production from chitin, my dissertation main content includes five chapters: 1) Chapter 1 highlights background information of chitin source, S. marcescens and potential metabolic engin

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Alfonso, Durruty Marta Pilar. "Biosignificance of Harris lines as stress markers in relation to moderate undernutrition and bone growth velocity a New Zealand white rabbit model for the study of bone growth /." Diss., Online access via UMI:, 2008.

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50

Vallaster, Markus Parzival. "Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/913.

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Abstract:

Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nico

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