Log in

Relevant bibliographies by topics / Biochemical Parameters and Histopathological Studies / Journal articles

To see the other types of publications on this topic, follow the link: Biochemical Parameters and Histopathological Studies.

Journal articles on the topic 'Biochemical Parameters and Histopathological Studies'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Biochemical Parameters and Histopathological Studies.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Sigacheva, T. B., and T. V. Gavruseva. "Diagnostic Value of Biochemical and Histopathological Characteristics of the Round Goby Neogobius melanostomus (Gobiidae) in Assessing of Aquatic Environment." Вопросы ихтиологии 63, no. 2 (2023): 226. http://dx.doi.org/10.31857/s0042875223020224.

Full text

Abstract:

Study of the transformation of biochemical reactions into histopathological alterations is of importance for their correct use as the biomarkers for early biodiagnostics of the aquatic environment quality. The purpose of the present investigation was to analyze the biochemical characteristics (activity of superoxide dismutase, catalase, aminotransferases, alkaline phosphatase, level of oxidized proteins and lipid peroxidation, albumin and urea concentrations) in tissues of round goby Neogobius melanostomus (Pallas, 1814) with different degrees of histopathological alterations. The results of h

APA, Harvard, Vancouver, ISO, and other styles

2

SHIMAA, A. B. D., S. A. E. EL-SAYED, and M. A. RIZK. "Significance of selected biochemical markers in predicting the outcome of schistosomiasis." Journal of the Hellenic Veterinary Medical Society 69, no. 1 (2018): 739. http://dx.doi.org/10.12681/jhvms.16397.

Full text

Abstract:

This study aimed to correlate the histopathological changes in mice liver with alterations either in liver tissue antioxidants enzymes (catalase and reduced glutathione (GSH)), oxidative stress marker (malondialdehyde (MDA)) or in serum liver function parameters (Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (T.P.) and albumin) to predict the outcome of schistosomiasis. Fourty male Swiss albino mice were used in this study and infected with Schistosoma mansoni for 2, 4, 6 and 8 weeks (8 mice for each group), while, the uninfected mice were used as negative con

APA, Harvard, Vancouver, ISO, and other styles

3

Santos, Joyce Alencar, Aline Arruda, Claudia Andrea Lima Cardoso, et al. "Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract ofJacaranda decurrensRoots in Adult Male Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/414821.

Full text

Abstract:

Jacaranda decurrenssubsp.symmetrifoliolataFarias & Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory and infectious diseases. Previous findings from our group reported scientifically thatJ. decurrenshas anti-inflammatory efficacy. However, more toxicological studies are needed to support and ensure its safe use. The present study was carried out to evaluate the toxic effects of a prolonged treatment with hydroethanolic root extract ofJ. decurrens(EJD) on hematological, biochemical, and reproductive parameters in adult male rats. The animals received b

APA, Harvard, Vancouver, ISO, and other styles

4

Chowdhury, Atanu Roy, Ramkrishna Brahmachari, and Soumyojit Saha. "Clinicobiochemical and pathological correlation in alcoholic liver disease among Indian patients." International Journal of Research in Medical Sciences 9, no. 3 (2021): 854. http://dx.doi.org/10.18203/2320-6012.ijrms20210890.

Full text

Abstract:

Background: Alcohol is one of the leading causes of “preventable” morbidity and mortality worldwide. It is associated with liver damage. A gray area is temporal relation between clinico-biochemical severity and histological changes in liver, neither this issue has been widely studied.Methods: A hospital based cross sectional clinico-pathological pilot study was undertaken in a tertiary care hospital in West Bengal in patients with a history of alcohol intake who had been admitted in the inpatient department of medicine. Assessment of patients with history of alcohol intake with respect to clin

APA, Harvard, Vancouver, ISO, and other styles

5

Amanat, Sasan, Fatemeh Ashkar, Mohammad Hassan Eftekhari, et al. "The effect of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices in rats with polycystic ovary syndrome." Clinical and Experimental Reproductive Medicine 48, no. 3 (2021): 236–44. http://dx.doi.org/10.5653/cerm.2020.04231.

Full text

Abstract:

Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, irregular menstruation, ovulatory dysfunction, and insulin resistance. Recent studies have reported the possible role of phytoestrogens in PCOS. This animal study aimed to evaluate the effects of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices on PCOS. Methods: PCOS was induced by 1 mg/kg of letrozole in adult Sprague-Dawley rats. The rats then received normal saline (PCOS group), 150 mg/kg of metformin, or 20 mg/kg of genistein dissolved in 1% methylcellulose sol

APA, Harvard, Vancouver, ISO, and other styles

6

Chika, Rose Onyema, Chinedu Ene Aloy, Nwazue Nwaoguikpe Reginald, and Uzoma Igwe Chidi. "Haematological and biochemical studies on Justicia secunda infusion used in treatment of anaemia." GSC Advanced Research and Reviews 20, no. 2 (2024): 057–68. https://doi.org/10.5281/zenodo.14948666.

Full text

Abstract:

The effect of ethanolic and infusion of <em>Justicia secunda</em> leaves in the animal organs was investigated using standard analytical protocols. A total of 40 albino rats divided into four groups of five rats each comprising one normal groups and three groups treated with 125, 250 and 500mg/kg body weight respectively. The infusion of <em>J. secunda</em> leaves was prepared using conventional methods. The hematological, biochemical and histological studies were also carried out as reported in previous literatures. The findings confirmed that <em>Justicia secunda</em

APA, Harvard, Vancouver, ISO, and other styles

7

Neha Sharma, Anila Negi, Dharambir Kashyap, Amanjit Bal, and Shalmoli Bhattacharyya. "Biochemical and histopathological evaluation of an in vivo model of breast cancer." GSC Biological and Pharmaceutical Sciences 16, no. 1 (2021): 202–10. http://dx.doi.org/10.30574/gscbps.2021.16.1.0193.

Full text

Abstract:

Though, the clinical management of breast cancer has improved significantly over the past 30 years, it still remains the leading cause of cancer-related female death worldwide. Prevention is the fundamental issue in breast cancer control, for which identification markers in terms of initiation and promotion are necessary. To understand this, an animal model which can recapitulate the early symptoms of breast cancer development and progression is required. Present study is an attempt to develop a convenient and economical in-vivo animal model of breast cancer suitable to conduct such study. Fem

APA, Harvard, Vancouver, ISO, and other styles

8

Fayzullin, Alexey, Natalia Ignatieva, Olga Zakharkina, et al. "Modeling of Old Scars: Histopathological, Biochemical and Thermal Analysis of the Scar Tissue Maturation." Biology 10, no. 2 (2021): 136. http://dx.doi.org/10.3390/biology10020136.

Full text

Abstract:

Mature hypertrophic scars (HSs) remain a challenging clinical problem, particularly due to the absence of biologically relevant experimental models as a standard rabbit ear HS model only reflects an early stage of scarring. The current study aims to adapt this animal model for simulation of mature HS by validating the time of the scar stabilization using qualitative and quantitative criteria. The full-thickness skin and perichondrium excision wounds were created on the ventral side of the rabbit ears. The tissue samples were studied on post-operation days (PODs) 30, 60, 90 and 120. The histopa

APA, Harvard, Vancouver, ISO, and other styles

9

Abd-Elhady, Hany Kamal, and Gamal Elsayed Abou-Elghar. "Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus." Journal of Plant Protection Research 53, no. 3 (2013): 263–70. http://dx.doi.org/10.2478/jppr-2013-0039.

Full text

Abstract:

Abstract Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects of abamectin were studied. The various biochemical parameters and histopathological changes were noted. A stomach tube was used to orally administer sublethal doses of abamectin suspended in corn

APA, Harvard, Vancouver, ISO, and other styles

10

Neha, Sharma, Negi Anila, Kashyap Dharambir, Bal Amanjit, and Bhattacharyya Shalmoli. "Biochemical and histopathological evaluation of an in vivo model of breast cancer." GSC Biological and Pharmaceutical Sciences 16, no. 1 (2021): 202–10. https://doi.org/10.5281/zenodo.5168650.

Full text

Abstract:

Though, the clinical management of breast cancer has improved significantly over the past 30 years, it still remains the leading cause of cancer-related female death worldwide. Prevention is the fundamental issue in breast cancer control, for which identification markers in terms of initiation and promotion are necessary. To understand this, an animal model which can recapitulate the early symptoms of breast cancer development and progression is required. Present study is an attempt to develop a convenient and economical <em>in-vivo </em>animal model of breast cancer suitable to cond

APA, Harvard, Vancouver, ISO, and other styles

11

Ghazanfar, Khalid, Showkat Ahmad Dar, Seema Akbar, et al. "Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats." Scientifica 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2683403.

Full text

Abstract:

Capsule Shaqeeqa, Unani formulation, is prescribed for the clinical treatment of diseases like sinusitis, headache, and migraine. The safety evaluation data of it is not available; in order to provide the safety data the present study was carried out. The study was carried out on four groups of rats (n=5). Two groups (one male and one female group) as normal controls were orally given water while the other two groups were orally given daily doses of drug at the dose level of 150 mg/kg of body weight for duration of 90 days. Physiological parameters like body weight, feed consumption, water con

APA, Harvard, Vancouver, ISO, and other styles

12

Dinc, Kemal, Sevil Kiremitli, Bahadir Suleyman, et al. "Effect of pycnogenol on ischemia/reperfusion-induced oxidative and inflammatory damage in the ovaries of rats." Tropical Journal of Pharmaceutical Research 22, no. 11 (2024): 2297–303. http://dx.doi.org/10.4314/tjpr.v22i11.8.

Full text

Abstract:

Purpose: To investigate the protective effect of pycnogenol (PYC) against ischemia/reperfusion (I/R) ovarian damage induced by experimental ovarian torsion in rats using biochemical and histopathological methods. Methods: Four groups of rats (n = 6) were randomly assigned and designated as follows – SG: sham group, PCG: pycnogenol (40 mg/kg) group, IRG: ovarian ischemia-reperfusion group, and PIR: pycnogenol (40 mg/kg) + ovarian ischemia-reperfusion group. In IRG and PYC treatment groups, ischemia was induced in the right ovary for two hours with vascular clips. The ovary was reperfused

APA, Harvard, Vancouver, ISO, and other styles

13

Hacıoğlu, Orkun, Rabia Buse Aksu, Sinem Yaren Akgül, and Tuğba Seval Fatma Toydemir Karabulut. "Hematological and blood biochemical differences in dogs with mammary dysplasia/ hyperplasia, bening or malignant mammary tumors." Journal of Istanbul Veterinary Sciences 8, no. 3 (2024): 273–81. https://doi.org/10.30704/http-www-jivs-net.1475777.

Full text

Abstract:

Mammary tumors are the most common neoplasms in female dogs. There are many factors involved in the development of mammary tumors. Recently, there is an increasing need for cost-effective prognostic markers derived from hematological parameters in dogs and cats with cancer. Our study was designed as a retrospective study to determine the significance of hematologic parameters in female dogs bearing with mammary tumors. For this, hematocrit (HCT), blood biochemistry, and some clinical and histopathological findings of female dogs with mammary gland masses that had undergone mastectomy (n = 100)

APA, Harvard, Vancouver, ISO, and other styles

14

Brasileiro de Vasconcelos, Carlos Fernando, Hélida Maria de Lima Maranhão, João Henrique da Costa-Silva, et al. "Chronic toxicological study of the stem bark aqueous extract from Libidibia ferrea Mart. ex Tul." Biomedical and Biopharmaceutical Research Journal 17, no. 2 (2020): 1–17. http://dx.doi.org/10.19277/bbr.17.2.238.

Full text

Abstract:

Libidibia ferrea Martius Ext Tul. has been used in popular medicine to treat a wide range of diseases such as diabetes, gastric ulcer, and cancer; however, no preclinical safety study of the stem bark aqueous extract has been identified. We studied the chronic toxicity of an aqueous extract of L. ferrea stem bark in mice with oral doses of 300 and 1500 mg/ kg/day for 12 weeks. As indicators of toxicity, body weight, as well as food and water intake, were evaluated. Analysis of biochemical and haematological parameters and histopathologic studies were also conducted. The groups treated with L.

APA, Harvard, Vancouver, ISO, and other styles

15

Mendes, PatrÍcia Franciscone, Karin Argenti Simon, and Isis Machado Hueza. "TOXIC AND IMMUNOTOXIC EVALUATION OF KETAMINE AND/OR ETHANOL IN RATS DURING 28 DAYS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 9 (2017): 205. http://dx.doi.org/10.22159/ijpps.2017v9i9.20582.

Full text

Abstract:

Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of this association.Methods: Wistar rats were distributed into four groups (n=8/group), each receiving one of the following treatments, for 28 d: K group (15 mg/kg of ketamine, intraperitoneally); E group [1.0 ml of ethanol 10% (approximately 0,08g/rat), gavage]; KE group, receiving both treatments; and Control (Co) group, receiving only vehicles. On day 29, animals were euthanized f

APA, Harvard, Vancouver, ISO, and other styles

16

Bala, N. "Toxicity Profiling of <i>Marsilea Minuta</i> Conjugated ZnO Nanoparticles for Therapeutics as Nanomedicine." Journal of Scientific Research 17, no. 1 (2025): 235–45. https://doi.org/10.3329/jsr.v17i1.71341.

Full text

Abstract:

Nanomedicine is widely explored nowadays for the treatment of life-threatening diseases, yet it comes with various challenges and questions. In this regard, the exploration of the sanative effect of nanoparticles on cell viability for therapeutic applications is going to be a highly developing research field. Nanomedicines should be properly screened before they can be proclaimed as future technology. The present study encapsulates the acute and sub-acute toxicological aspects of the Marsilea minuta conjugated ZnO (MM-ZnO) nanohybrids synthesized. Biochemical, hematological, and histopathologi

APA, Harvard, Vancouver, ISO, and other styles

17

Al-Rasheed, Nouf M., Laila Fadda, Hala A. Attia, Iman A. Sharaf, Azza M. Mohamed, and Nawal M. Al-Rasheed. "Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats." Acta Pharmaceutica 67, no. 1 (2017): 125–35. http://dx.doi.org/10.1515/acph-2017-0010.

Full text

Abstract:

AbstractThe study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO2injection caused a significant decrease in Hb in rats, while serum levels of TNF-α, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO2injection markedly reduced these parameters. Histopathological examina

APA, Harvard, Vancouver, ISO, and other styles

18

Genç, Buğra, Nilüfer Kuruca, Gül Fatma Yarım, et al. "Use of Fermented Black Tea (Camellia sinensis) Factory Wastes in Standard Rat Diets." Veterinary Sciences 12, no. 5 (2025): 451. https://doi.org/10.3390/vetsci12050451.

Full text

Abstract:

Although there are studies on the use of different tea extracts in animal diets, there are no studies on the use of fermented black tea factory production waste (FTFW) in rodent diets. This study aims to evaluate the effects of FTFW, considered an environmentally hazardous waste, in standard rat diets regarding nutritional, histopathological, and biochemical parameters. In this study, 40 male Wistar albino rats (70 days old, with a live weight of 200–250 g) were divided into four groups, each containing 10 rats. They were fed standard rat diets for 63 days, with varying amounts (0%, 3%, 5%, an

APA, Harvard, Vancouver, ISO, and other styles

19

Tolouei, SEL, GN da Silva, TZ Curi, et al. "Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats." Human & Experimental Toxicology 40, no. 1 (2020): 124–35. http://dx.doi.org/10.1177/0960327120945756.

Full text

Abstract:

Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as “major gomes,” is a Brazilian Cerrado plant used in traditional medicine and as a food source. Recent studies have demonstrated its diuretic effects. However, no studies have been performed on its effects on the reproductive system. Therefore, we aimed to investigate the effects of the ethanol-soluble fraction of T. paniculatum leaves (ESTP) on general toxicity and on the pubertal development of male and female Wistar rats. For this purpose, the uterotrophic and the pubertal assays were performed. In the uterotrophic test, fe

APA, Harvard, Vancouver, ISO, and other styles

20

I.U., Muhammad, Alhassan A.J., Imam A.A., Muhammad Y.Y., Mohammed A., and Alexander I. "Effect of Transfluthrin-Impregnated Insecticide Paper on Some Biochemical Parameters and Lung Histopathology in Rats." Chemistry Research Journal 2, no. 5 (2017): 9–14. https://doi.org/10.5281/zenodo.13950426.

Full text

Abstract:

Serum malondealdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and histological analysis of lungs were carried out in twenty rats exposed to smoke from transfluthrin impregnated insecticide paper. The rats were divided into five groups (I, II, III, IV and V) of four each. Group one served as control while Group II, III, IV and V were exposed to smoke from transfluthrin impregnated paper Insecticide for 15, 30, 60, 120 minutes daily for four weeks respectively. On the 29th day all the rats in the five groups were euthanized and blood sa

APA, Harvard, Vancouver, ISO, and other styles

21

Khalifa, Mohammed Ali, Amna Elhassan Hamad Mohammad, and Basher Mohamed Ahmed. "Acute and Subacute Toxicity Studies of Cyperus Papyrus Ash on Wistar Albino Rats." Pharmaceutical and Biomedical Research 8, no. 4 (2022): 279–90. http://dx.doi.org/10.32598/pbr.8.4.1021.1.

Full text

Abstract:

Background: Acute and subacute toxicity screenings of medicinal plants are the fastest way to evaluate the toxicological profiles of medicinal plants. It helps to have a quick idea of the harm or safety potency of drugs. This study aims to conduct an acute and subacute oral toxicity study on the Cyperus Papyrus (CP) ash in Wistar albino rats. CP is traditionally used for managing painful spasms, eye diseases, ulcers, fever, diarrhea, and inflammations. Further study is required to reflect the safety profile of this plant ash. Methods: Acute oral toxicity study of the CP ash was evaluated by us

APA, Harvard, Vancouver, ISO, and other styles

22

Souza, Keicy Sandy Silvestre de, Anna Christina de Almeida, Stephanie Pedrosa de Oliveira, et al. "Glycemic profile, inflammatory markers, biochemical and histopathological parameters of mice fed with fermented dairy beverage with clove essential oil." Research, Society and Development 10, no. 4 (2021): e22110413826. http://dx.doi.org/10.33448/rsd-v10i4.13826.

Full text

Abstract:

Previous studies have shown that the clove essential oil concentration of 200 mg/kg did not present toxicity and histopathological changes in the liver. Based on the evidence presented in this study, we decided to evaluate in vivo the ability of a previously developed fermented dairy beverage, tested only in vitro, in which the standard chemical preservative, potassium sorbate, was replaced by clove essential oil (2 μl/ml), to be a functional food. To this end, twenty-four male Swiss mice were divided into three groups and submitted insulin sensitivity (IST) and glucose tolerance (GTT) testing

APA, Harvard, Vancouver, ISO, and other styles

23

Kumar, Sunil, Priyanka Kumari, and Shoma Devi. "Antioxidative role of selected herbs against ethanol induced liver injury in rats." Journal of Applied and Natural Science 3, no. 2 (2011): 242–46. http://dx.doi.org/10.31018/jans.v3i2.187.

Full text

Abstract:

The purpose of this study was to know the hepatotoxicity of ethanol in laboratory rats Rattus rattus and to observe the individual and combined phytotherapeutic role of five herbs viz. Arctium lappa, Curcuma longa, Piper longum, Plumbago zeylanica and Terminalia chebula through biochemical and histopathological parameters. Ethanol is commonly used as solvent, pharmaceutical, drugs and alcohol abuse. Lipidperoxidation, glutathione content, urinary hydroxyproline, collagen and histopathological studies showed hepatotoxicity of 1 ml/kg bodyweight dose of ethanol and protective role of 100 mg/kg b

APA, Harvard, Vancouver, ISO, and other styles

24

Grewal, Amarjot Kaur, Nirmal Singh, and Thakur Gurjeet Singh. "Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway." Canadian Journal of Physiology and Pharmacology 97, no. 11 (2019): 1094–101. http://dx.doi.org/10.1139/cjpp-2019-0188.

Full text

Abstract:

Evidence has demonstrated that resveratrol preconditioning exhibits neuroprotection against cerebral ischemia–reperfusion (IR) injury. The current investigation aimed to explore whether pharmacological postconditioning, by administering resveratrol, after a sustained ischemia and prior to prolonged reperfusion abrogates cerebral IR injury. Cerebral IR-induced injury mice model was employed in this study to evaluate the neuroprotective effects of pharmacological postconditioning with resveratrol (30 mg/kg; i.p.) administered 5 min before reperfusion. We administered sirtinol, a SIRT1/2 selectiv

APA, Harvard, Vancouver, ISO, and other styles

25

Onu, A., Y. Saidu, M. J. Ladan, L. S. Bilbis, A. A. Aliero, and S. M. Sahabi. "Effect of Aqueous Stem Bark Extract ofKhaya senegalensison Some Biochemical, Haematological, and Histopathological Parameters of Rats." Journal of Toxicology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/803835.

Full text

Abstract:

The subchronic effect of aqueous stem bark extract ofKhaya senegalensison some biochemical, haematological, and histopathological parameters of rats was investigated. The rats were divided into six groups of five rats per group. Groups I to VI were administered graded doses of 0, 400, 800, 1200, 1600, and 2000 mg/kg bw, respectively. The result of study revealed that administration of theKhaya senegalensisfor twenty-eight days at the experimental dose resulted in significant (P<0.05) increase in urea, electrolytes (Na+, K+), and creatinine levels. The extract also significantly (P<0.05)

APA, Harvard, Vancouver, ISO, and other styles

26

P, Parameshwar, Y. N. Reddy, and Aruna Devi M. "Hepatoprotective and Antioxidant Activities of Zizphus rotundifolia (Linn.) against Carbon Tetrachloride-Induced Hepatic Damage in Rats." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 3 (2012): 1775–79. http://dx.doi.org/10.37285/ijpsn.2012.5.3.4.

Full text

Abstract:

 Many hepatoprotective herbal preparations have been recommended in alternative system of medicine for the treatment of hepatic disorders. There are few or no systemic studies have been done on protective efficacy of Ziziphus rotundifolia (Rhamnaceae) to treat liver diseases. In this study, hepatoprotective and antioxidant activity of ethanolic extracts was evaluated against CCl4-induced liver damage in rats. Liver damage was evidenced by elevated levels of biochemical parameters such as serum glutamate oxaloacetic acid transaminase, glutamate pyruvic transaminase and serum alkaline phos

APA, Harvard, Vancouver, ISO, and other styles

27

Filazi, Ayhan, Meltem Sireli, and Faruk Kalkan. "The influence of amitraz on biochemical parameters in mice." Human & Experimental Toxicology 22, no. 2 (2003): 99–101. http://dx.doi.org/10.1191/0960327103ht339cr.

Full text

Abstract:

In this study, the effect of amitraz on biochemical parameters of mice was studied. Mice were given amitraz by gavage at 15 or 45 mg/kg body weight. Since the drug was diluted with dimethylsulphoxide (DMSO), it was administered to another experimental animal group in order to determine its own effects on biochemical parameters. Following drug administration, 48 hours passed to let hepatic lesions develop and after that 1 mL of blood was taken from each mouse. They were killed by ether euthanasia for histopathological examination. The result of the analyses revealed that amitraz had no effect o

APA, Harvard, Vancouver, ISO, and other styles

28

Gonçalves, Meline Gomes, Matheus Anselmo Medeiros, Licyanne Ingrid Carvalho de Lemos, et al. "Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats." Nutrients 14, no. 3 (2022): 431. http://dx.doi.org/10.3390/nu14030431.

Full text

Abstract:

Diabetes mellitus (DM) is a worldwide health concern, and projections state that cases will reach 578 million by 2030. Adjuvant therapies that can help the standard treatment and mitigate DM effects are necessary, especially those using nutritional supplements to improve glycemic control. Previous studies suggest creatine supplementation as a possible adjuvant therapy for DM, but they lack the evaluation of potential morphological parameters alterations and tissue injury caused by this compound. The present study aimed to elucidate clinical, histomorphometric, and histopathological consequence

APA, Harvard, Vancouver, ISO, and other styles

29

Boye, Abayneh Tunta, Peter Etim Ekanem, Tesfamichael Berhe Hailu, Ifa Dereje Hordofa, and Mulu Shiferaw Asfaw. "Histopathological Evaluation of Ethanolic Leaf Extract of Lippia adoensis on Liver, Kidney, and Biochemical Parameters in Swiss Albino Mice." Hepatic Medicine: Evidence and Research Volume 14 (September 2022): 123–33. http://dx.doi.org/10.2147/hmer.s370927.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Weerakoon, Weerakoon Achchige Selvi Saroja, Pathirage Kamal Perera, Kamani Samarasinghe, Dulani Gunasekera, and Thusharie Sugandhika Suresh. "Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension." Evidence-Based Complementary and Alternative Medicine 2020 (November 28, 2020): 1–8. http://dx.doi.org/10.1155/2020/2891058.

Full text

Abstract:

Sudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. This study was aimed to determine the safety profile of the SP, and its novel preparation Sudarshana suspension (SS) on male Wistar rats and tolerance studies were conducted for healthy adult volunteers. Acute and subacute toxicity studies of the SS and hot water extract of SP were assessed in Wistar rats by observing the general behavior, analyzing biochemical and haematological parameters, and pathological observation. Heal

APA, Harvard, Vancouver, ISO, and other styles

31

Okpalakunne, SE, PC Unekwe, LC Chukwu, JE Okwara, and Aliyu Ramalan Mansur. "A scientific compendium of the effects of sildenafil citrate on the liver, kidney and heart of male albino rats at Nnewi, South East Nigeria." World Journal of Biology Pharmacy and Health Sciences 4, no. 2 (2020): 056–74. https://doi.org/10.5281/zenodo.4430957.

Full text

Abstract:

This study investigated the various effects of Sildenafil citrate on the liver, kidney and heart of male <em>albino rats</em>. Twenty eight male rats randomly divided into 4 groups and weighing 131-214g were used. While the animals in group 1 (control) received food and water only, those in the study groups 2,3&4 respectively received 25mg/kg, 50mg/kg and 100mg/kg of Sildenafil citrate orally, daily for 4 weeks. All animals were sacrificed and blood samples collected by cardiac puncture for analysis of biochemical parameters. The rats Liver, kidneys and hearts were subjected to histop

APA, Harvard, Vancouver, ISO, and other styles

32

Enoch Chibuike Okorochi, Chinenye Mary Okorochi, Innocent Onuoha, Jegede Olushola Olayinka, Adeyinka Samson Akinyo, and Mercy Ebriphiyo Eghagha. "Biochemical and histopathological effects of Moringa oleifera aqueous leaf extract on the kidney function in male Wistar rats." World Journal of Advanced Research and Reviews 26, no. 2 (2025): 3760–66. https://doi.org/10.30574/wjarr.2025.26.2.1981.

Full text

Abstract:

Moringa oleifera, a plant known for its nutritional and medicinal properties, has gained popularity in traditional and modern medicine. This study aimed to evaluate the effects of Moringa oleifera leaf extract on the histological and biochemical components of the kidney in male Wistar rats (Rattus norvegicus), hypothesizing that the extract may induce organ toxicity. Forty-eight rats were divided into four groups, receiving varying doses of the extract (1000, 2000, and 3000 mg/kg) for three weeks. Biochemical parameters, including urea and creatinine, were assessed, alongside histological exam

APA, Harvard, Vancouver, ISO, and other styles

33

Pandey, Rajat, and Ramakant Singh. "Azidothymidine induces severe hematological toxicity and hepatic injury in Charles Foster rats." International Journal of Basic & Clinical Pharmacology 6, no. 9 (2017): 2125. http://dx.doi.org/10.18203/2319-2003.ijbcp20173637.

Full text

Abstract:

Background: The present study aimed at evaluating the effects of azidothymidine (AZT) on hematologic and biochemical parameters in Charles Foster rats.Methods: Twelve adult healthy Charles Foster rats comprising of six male and six females were selected for study. Test rodents were divided into four groups containing three rodents each. Three males and three females served as control and remaining received AZT drug. Rodents were acclimatized for 10 days and drug was administered for 28 days. After the completion of drug administration, blood samples were collected and analyzed for hematologic

APA, Harvard, Vancouver, ISO, and other styles

34

Reddy, R. Mallikarjuna, Srikanth A, Sofia Kouser, et al. "Pharmacological Evaluation of the Impact of Fluoride-Contaminated Drinking Water on Brain Cognitive Function and Bone Health in Nalgonda and Warangal Rural Districts of Telangana in India." International Journal of Pharmaceutical Sciences and Nanotechnology 13, no. 4 (2020): 5036–46. http://dx.doi.org/10.37285/ijpsn.2020.13.4.10.

Full text

Abstract:

A systematic groundwater analysis was carried out in six villages of Narsampet in Warangal district and two villages of Narketpally in Nalgonda district of Telangana in India. These water samples were collected from respective areas and evaluated under four different categories viz. physico-chemical parameters (such as pH, Electric Conductivity (EC), Total Dissolved Solids (TDS), Turbidity, Alkalinity, Hardness, Chloride, Nitrates, Sulphates, Fluoride, Iron content) as per standard methods, behavioral changes i.e. measurement of learning and memory ability of rats (Rectangular maze, Morris wat

APA, Harvard, Vancouver, ISO, and other styles

35

Adams, R., B. I. Idemudia, E. E. Imarhiagbe, B. Ikhajiagbe, and F. O. Ekhaise. "EVALUATION OF POULTRY HOUSE DUST AND ITS EFFECT ON THE BIOCHEMICAL, HAEMATOLOGICAL AND HISTOLOGICAL PARAMETERS OF WISTAR RATS IN EDO STATE." Open Journal of Medical Research (ISSN: 2734-2093) 3, no. 1 (2022): 01–11. http://dx.doi.org/10.52417/ojmr.v3i1.307.

Full text

Abstract:

Poultry farmers and birds are exposed to poultry dust which is a byproduct of commercial poultry production. It increases the chances of developing serious respiratory conditions. Adult male Wistar rats were used in this study due to their stable hormonal status to investigate the effect of poultry dust (PM10) on the biochemical, haematological and histopathological parameters of the animals. The Wistar rats were exposed to dust samples collected from 9 poultry farms in Edo State. Indoor concentration of dust samples was determined monthly using a Casella Cel 712 micro dust pro air sampler fro

APA, Harvard, Vancouver, ISO, and other styles

36

Srividya, G., K. Adilaxmamma, and C. H. Srilatha. "PROTECTIVE EFFECT OF ACORUS CALAMUS RHIZOME IN PARACETAMOL EXPOSURE INDUCED HEPATOTOXICITY IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY." International Journal of Current Pharmaceutical Research 10, no. 3 (2018): 7. http://dx.doi.org/10.22159/ijcpr.2018v10i3.27218.

Full text

Abstract:

Objective: To study the hepatoprotective activity of an aqueous and alcoholic extract of Acorus calamus rhizomes against the paracetamol induced hepatotoxicity in rats.Methods: Hepatotoxicity was induced by oral administration of paracetamol and chemical parameters such as Glutathione peroxidase, Glutathione reductase, Glutathione, Catalase, lipid peroxidation and histopathological changes in liver was studied by comparing with Silymarin, a standard hepatoprotective drug.Results: Treatment of rats with aqueous and alcoholic extract of Acoruscalamus rhizome after paracetamol administration norm

APA, Harvard, Vancouver, ISO, and other styles

37

Rehman, Hasibur, Al Thbiani Aziz, Shalini Saggu, Adam L. VanWert, Nahla Zidan, and Sundeep Saggu. "Additive toxic effect of deltamethrin and cadmium on hepatic, hematological, and immunological parameters in mice." Toxicology and Industrial Health 33, no. 6 (2017): 495–502. http://dx.doi.org/10.1177/0748233716684710.

Full text

Abstract:

Exposure to natural and man-made environmental toxins concurrently can pose a greater threat to multiple organs. In the present work, we investigated interactions between deltamethrin (DM) and cadmium (Cd), whose mechanisms of action in humans are poorly understood. Albino mice were randomly divided into four groups, each containing six mice: saline as control, DM-treated, cadmium chloride (CdCl2)-treated, and CdCl2 plus DM treated. After 2 weeks of treatment biochemical and hematological effects, total leukocyte count (TLC), differential leukocyte count, humoral-mediated immune responses, and

APA, Harvard, Vancouver, ISO, and other styles

38

G, Gamit Kanan, and Raval Manan A. "TOXICOLOGICAL EVALUATION OF AYURVEDIC FORMULATION: GOKSHURADI GUGGULU." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 57. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19295.

Full text

Abstract:

Objective: To evaluate toxicological studies of Ayurvedic formulation Gokshuradi Guggulu (GG) on male Wistar rats.Methods: Acute toxicity study was conducted as per the Organisation for Economic Co-operation and Development guidelines.Results: Results from the present study have elucidated that treatment with GS exerted no significant signs of toxicity at dose level 2000 mg/kg body wt. There was no mortality observed in all the groups. Behavioral, biochemical, and hematological parameters and histopathological studies were not significantly much altered as compared to control group.Conclusion:

APA, Harvard, Vancouver, ISO, and other styles

39

Belem-Kabré, Wendkouni Leila Marie Esther, Ollo Da, Ernest Nogma Sombié, et al. "Therapeutic effect of aqueous extract from Ampelocissus africana (Lour) Merr rhizomes on testosterone-induced benign prostatic hyperplasia in Wistar rats." Journal of Herbmed Pharmacology 13, no. 2 (2024): 199–207. http://dx.doi.org/10.34172/jhp.2024.42388.

Full text

Abstract:

Introduction: Ampelocissus africana is a medicinal plant used to treat several diseases, including those affecting the prostate. This study investigated the effects of the aqueous extract of rhizomes from Ampelocissus africana (AAA) on a testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) model. Methods: The effect of the extract at 50, 150, and 300 mg/kg on BPH in male rats was assessed using daily subcutaneous injections of 3 mg/kg TP for four consecutive weeks. After the induction schedule, physical parameters, prostate index (PI), serum biochemical parameters, homogenat

APA, Harvard, Vancouver, ISO, and other styles

40

Salokhe, Shivani Shashikant, S. U. Kolhe, S. V. Tembhurne, and Dipali Hanmghar. "28 Days repeated oral toxicity study of Rosmarinus officinalis in Wistar Rats." Journal of Drug Delivery and Therapeutics 10, no. 6-s (2020): 67–74. http://dx.doi.org/10.22270/jddt.v10i6-s.4616.

Full text

Abstract:

Rosmarinus officinalis has long been used as a traditional oriental medicine. It is traditionally used as antioxidants as well as essential oil. Rosmarinus officinalis mainly contains the phenolic compounds which is responsible for the antioxidant property. In the present study, 28-day subacute oral dose toxicity studies of hydroalcoholic extracts of the plant of Rosmarinus officinalis were performed in Wistar rats. The repeated oral toxicity study was carried out to detect the no-observed adverse effect level (NOAEL). In this study, a total of 48 rats were classified into the control, low dos

APA, Harvard, Vancouver, ISO, and other styles

41

Shaikh, Sohrab A., Rajavel Varatharajan, and Arunachalam Muthuraman. "Palm Oil Derived Tocotrienol-Rich Fraction Attenuates Vascular Dementia in Type 2 Diabetic Rats." International Journal of Molecular Sciences 23, no. 21 (2022): 13531. http://dx.doi.org/10.3390/ijms232113531.

Full text

Abstract:

Vascular dementia (VaD) is a serious global health issue and type 2 diabetes mellitus (T2DM) patients are at higher risk. Palm oil tocotrienol-rich fraction (TRF) exhibits neuroprotective properties; however, its effect on VaD is not reported. Hence, we evaluated TRF effectiveness in T2DM-induced VaD rats. Rats were given a single dose of streptozotocin (STZ) and nicotinamide (NA) to develop T2DM. Seven days later, diabetic rats were given TRF doses of 30, 60, and 120 mg/kg orally for 21 days. The Morris water maze (MWM) test was performed for memory assessment. Biochemical parameters such as

APA, Harvard, Vancouver, ISO, and other styles

42

Nishat Fathima, Syeda, and S. Vasudeva Murthy. "CARDIOPROTECTIVE EFFECTS TO CHRONIC ADMINISTRATION OF ROSA DAMASCENA PETALS IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION: BIOCHEMICAL, HISTOPATHOLOGICAL AND ULTRASTRUCTURAL STUDIES." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1155–66. http://dx.doi.org/10.13005/bpj/1744.

Full text

Abstract:

The present study is designed to evaluate the cardioprotective effect of Rosa damascena petals called rose on isoproterenol-induced myocardial infarction in experimental rats. The experimental rats were divided into 4 groups, each consisting of 6 animals. Group 1 rats received standard diet and drinking water ad libitum for 45 days and will serve as a control group. Group 2 received a standard diet and drinking water ad libitum for 45 days. Group 3 Rats received metoprolol succinate via oral route at a daily dosage of 2.5 mg/Kg body weight for a period of 45 days. Group 4 Rats received Rosa da

APA, Harvard, Vancouver, ISO, and other styles

43

C. B, Harisha, Shridhar N.B, Sunilchandra U, et al. "Toxicological studies of Ageratum conyzoides in rats." International Journal of Zoology and Applied Biosciences 8, no. 3 (2023): 32–52. http://dx.doi.org/10.55126/ijzab.2023.v08.i03.006.

Full text

Abstract:

The study was taken up to evaluate the pharmacological and toxicological property of A. conyzoides plant. The yield of methanolic extract was found to be 6.8 %. The pH of methanolic extract of A. conyzoides (MEAC) was 5.86. It was dark green in colour and the was dry and powdery in consistency with aromatic odour. Acute oral and repeated dose 28-day oral toxicity studies of methanolic extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In sub-acute oral toxicity dose levels of 500, 1000 and 1500 mg/kg were administered daily for 28 days and compar

APA, Harvard, Vancouver, ISO, and other styles

44

Markkas, N., and Madhuramozhi Govindharajalu. "Protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats." Journal of Phytopharmacology 7, no. 1 (2018): 1–4. http://dx.doi.org/10.31254/phyto.2018.7101.

Full text

Abstract:

Diabetes mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Liver is the central metabolic organ in body responsible for glucose homeostasis, diabetes leads to hepatic dysfunction. In the present study to investigate the protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats. Hepatospecific enzymes (ALP, ALT and AST), protein and albumin content were activated when hepatocellular

APA, Harvard, Vancouver, ISO, and other styles

45

Abutaha, Nael, Mohammed Al-zharani, Amin A. Al-Doaiss, Almohannad Baabbad, Ahmed Mfreh Al-malki, and Hafedh Dekhil. "Anticancer, antioxidant, and acute toxicity studies of a Saudi polyherbal formulation, PHF5." Open Chemistry 18, no. 1 (2020): 472–81. http://dx.doi.org/10.1515/chem-2020-0047.

Full text

Abstract:

AbstractA popular polyherbal formulation prepared from five plants (PHF5) may have anticancer effects. However, there is a lack of adequate scientific evidence. We assessed the anticancer, antioxidant, and acute toxicity effects of PHF5. Cancer cells were treated with 0 to 300 μg/mL PHF5 extract. Established assays were used to assess cytotoxicity, apoptosis, and radical scavenging activities. In the acute toxicity study, mice were administered a single oral dose (2,000 mg/kg) of PHF5, and biochemical and histopathological parameters were assessed. The IC50 values of PHF5 on LoVo, HepG2, MCF-7

APA, Harvard, Vancouver, ISO, and other styles

46

Eslamifar, Zahra, Abbas Moridnia, Susan Sabbagh, Reza Ghaffaripour, Leila Jafaripour, and Mahin Behzadifard. "Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression." BioMed Research International 2021 (October 26, 2021): 1–11. http://dx.doi.org/10.1155/2021/2195238.

Full text

Abstract:

Background. Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation of the drug in renal proximal tubule cells causes nephrotoxicity and renal failure. Investigations showed nephrotoxicity as Cisplatin’s dose-limiting side effect. One of the Cisplatin toxicity mechanisms is generation of reactive oxygen species, which leads to oxidative stress and renal damage. The purpose of this study was evaluation of the modulating effects of Gallic acid on Cisplatin-induced variations including Caspase-3 and Clusterin expression and histopathological and bio

APA, Harvard, Vancouver, ISO, and other styles

47

Pongri, Adarki, and Ighodaro Igbe. "Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats." Herba Polonica 63, no. 3 (2017): 35–47. http://dx.doi.org/10.1515/hepo-2017-0017.

Full text

Abstract:

Summary Introduction: Different parts of Grewia mollis Juss. (Malvaceae) are commonly used in folk medicine to treat several ailments, including diarrhea, ulcers, rickets, cough and fever. Although several studies have proved its therapeutic effectiveness, there are very few toxicological studies on the plant. Objectives: This study was carried out to evaluate the acute and sub-chronic toxicity of the aqueous extract of G. mollis stem bark (GM) in animals. Methods: In the acute study, rats were orally administrated with GM at doses of 150, 300, 600, 1200, 2400, 4800 and 9600 mg/kg to determine

APA, Harvard, Vancouver, ISO, and other styles

48

Asiedu-Gyekye, Isaac J., Abdulai Seidu Mahmood, Charles Awortwe, and Alexander K. Nyarko. "Toxicological assessment of polyhexamethylene biguanide for water treatment." Interdisciplinary Toxicology 8, no. 4 (2015): 193–202. http://dx.doi.org/10.1515/intox-2015-0029.

Full text

Abstract:

Abstract Polyhexamethylene biguanide (PHMB) is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. There are regulatory concerns with regard to its safety in humans for water treatment. We decided to assess the safety of this chemical in Sprague-Dawley rats. PHMB was administered in a single dose by gavage via a stomach tube as per the manufacturer’s instruction within a dose range of 2 mg/kg to 40 mg/kg. Subchronic toxicity studies

APA, Harvard, Vancouver, ISO, and other styles

49

Kavita Kumari , Dr Umesh Kumar Gilhotra , Dr Rakesh Chawla. "HEPATOPROTECTIVE ACTIVITY OF NATURAL PLANTS IN ALBINO WISTAR RATS." Cuestiones de Fisioterapia 54, no. 4 (2025): 198–214. https://doi.org/10.48047/1gby7m56.

Full text

Abstract:

The aim of this study was Evaluation of hepatoprotective activity of natural plants in albino Wistarrats. In this study three plant was selected Dalbergia Sissoo, Hibiscus Rosa and Quisqualis Indicaand its ethanolic and hydro-alcoholic extract was prepared. Albino Wistar rats selected as animalfor this study. Extracted sample was used for the hepatoprotective activity in CCI4 inducedhepatotoxicity in rats. Silymarin was taken as standard drug. Various biochemical parameters asSGPT, SGOT, alkaline phosphatase, total bilirubin, total protein, Cholesterol were estimated byusing commercially avail

APA, Harvard, Vancouver, ISO, and other styles

50

Turkez, Hasan, Serkan Yıldırım, Elvan Sahin, et al. "Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study." Toxics 10, no. 8 (2022): 428. http://dx.doi.org/10.3390/toxics10080428.

Full text

Abstract:

Genetic, neuropathological and biochemical investigations have revealed meaningful relationships between aluminum (Al) exposure and neurotoxic and hematotoxic damage. Hence, intensive efforts are being made to minimize the harmful effects of Al. Moreover, boron compounds are used in a broad mix of industries, from cosmetics and pharmaceuticals to agriculture. They affect critical biological functions in cellular events and enzymatic reactions, as well as endocrinal and mineral metabolisms. There are limited dose-related data about boric acid (BA) and other boron compounds, including colemanite

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!