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Journal articles on the topic 'Biochemistry and cell biology not elsewhere classified'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2023

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1

Ho, Gwendolyn, Ted Wun, Qian Li, Ann M. Brunson, Aaron S. Rosenberg, Brian Jonas, and Theresa Keegan. "Decreased Early Mortality Associated with Treatment of Acute Myeloid Leukemia (AML) at NCI-Designated Cancer Centers in California." Blood 128, no. 22 (December 2, 2016): 391. http://dx.doi.org/10.1182/blood.v128.22.391.391.

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Abstract Background Patients with solid tumors treated at a National Cancer Institute designated cancer center (NCI-CC) have been found to have improved survival when compared to those treated elsewhere. Few population-based studies have evaluated the association between location of care, complications associated with intensive therapy and early mortality (defined here as death ² 60 days from diagnosis) in patients with AML. Methods Using linked data from the California Cancer Registry and Patient Discharge Dataset from 1999 to 2012, we identified patients ³15 years of age diagnosed with AML w

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2

Atrash, Shebli, Qing Zhang, Xenofon Papanikolaou, Christoph Heuck, Aziz Bakhous, Jameel Muzaffar, Al-Ola Abdallah, and Bart Barlogie. "Characteristics and Prognosis Of IgM Multiple Myeloma." Blood 122, no. 21 (November 15, 2013): 1881. http://dx.doi.org/10.1182/blood.v122.21.1881.1881.

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Abstract Introduction Multiple Myeloma (MM) is considered a malignancy of post germinal center long-lived plasma cells. Nevertheless T-cell independent antigen stimulation before the exposure of the B-cell to the germinal center can happen and results to IgM secreting short lived plasma cells and lymphoplasmacytes representing thus a potential alternative normal counterpart for IgM plasma cell dyscrasias. IgM myeloma is an infrequent subtytpe of MM with an estimated prevalence of 0.5%. Due to its rarity little is known about its characteristics and prognosis in comparison with Waldestrom’s mac

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3

Gallamini, Andrea, Alessandro Rambaldi, Alberto Biggi, Silvia Tavera, Caterina Patti, Caterina Stelitano, Alessandro M. Gianni, et al. "BEACOPP Chemotherapy Is Able to Induce Durable Complete Remission in Poor-Prognosis Hodgkin’s Lymphoma Patients with a Positive Interim PET after 2 ABVD Cycles." Blood 112, no. 11 (November 16, 2008): 2594. http://dx.doi.org/10.1182/blood.v112.11.2594.2594.

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Abstract Background: Early interim-PET (PET-2) is the most powerful factor able to predict treatment outcome in advanced-stage Hodgkin Lymphoma (HL) patients treated with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine). The 2-y PFS of PET-2 positive patients is only 12%, but the optimal treatment for this patient subset is still unknown. For this reason in January 2006 a treatment policy was designed by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) to early intensify chemotherapy with BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine,

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4

Rotulo, Gioacchino Andrea, Blandine Beaupain, and Jean Donadieu. "ELANE Neutropenia Beyond the Classification into Cyclic Neutropenia and Severe Congenital Neutropenia: The Inconstant Time Clock." Blood 138, Supplement 1 (November 5, 2021): 986. http://dx.doi.org/10.1182/blood-2021-149759.

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Abstract Introduction: ELANE neutropenia represents the cause of 25-30% of the cases of congenital neutropenia. Classically, its appears in the literature as in OMIM, under two distinct entities: Severe congenital neutropenia (SCN) and cyclic neutropenia (CyN). The delineation between the 2 entities is the "cyclicity" i.e. the periodic variation of the absolute neutrophils count (ANC), also called a 21-day time clock 1. However, it is extremely difficult to obtain enough sequential complete blood counts (CBC) at the onset of the disease, during an enough length period, while the patient is not

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5

Masarova, Lucia, Prithviraj Bose, Naveen Pemmaraju, Zeev E. Estrov, Lingsha Zhou, Sherry A. Pierce, Jorge E. Cortes, Hagop M. Kantarjian, and Srdan Verstovsek. "Evaluation of Cytogenetic Stratifications in Myelofibrosis." Blood 132, Supplement 1 (November 29, 2018): 1763. http://dx.doi.org/10.1182/blood-2018-99-120225.

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Abstract Introduction: The revised cytogenetic risk stratification of patients with primary myelofibrosis (PMF) divided patients into 3 prognostic categories, with additional new category of very high risk patients (VHR). This score should enhance traditional classification incorporated in the Dynamic International Prognostic Scoring System-Plus (DIPPS-Plus). Objective: To evaluate the prognostic utility of cytogenetic stratifications (DIPSS-Plus and the revised cytogenetic model) in patients with PMF referred to our institution between 1984 and 2016. Methods: We retrospectively reviewed the c

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6

Nakano, Nobuaki, Hiroo Katsuya, Takahiro Itoyama, Mototsugu Shimokawa, Atae Utsunomiya, Shuichi Hanada, Tetsuya Eto, et al. "Impact of Chromosomal Abnormalities in Acute and Lymphoma Types Adult T-Cell Leukemia-Lymphoma." Blood 128, no. 22 (December 2, 2016): 4123. http://dx.doi.org/10.1182/blood.v128.22.4123.4123.

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Abstract Background: Adult T-cell leukemia-lymphoma (ATL), which is a hematological malignancy related to human T-lymphotropic virus type I (HTLV-1), is known as a malignant lymphoid disease with poor prognosis. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered a treatment modality to contribute prolonging the survival in some population of patients (Katsuya H et al. 2015 Blood). A small study indicated that ATL cells frequently have chromosomal abnormalities including various numerical aberrations and complex structural abnormalities (Kamada N et al. Cancer Res. 199

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7

Tomlins, Jo, Nick Telford, Mike Dennis, Tim Somervaille, Adrian Bloor, Jim Cavet, Mike Green, Sven Armin Sommerfeld, John Murray, and Samar Kulkarni. "Population Based Study of Cytogenetic Abnormalities in Addition to Philadelphia (Ph) Chromosome in Patients with Chronic Myeloid Leukaemia (CML) and Impact on Survival." Blood 124, no. 21 (December 6, 2014): 4567. http://dx.doi.org/10.1182/blood.v124.21.4567.4567.

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Abstract Ph chromosome is the hallmark of CML. However there are few reports of additional chromosomal abnormalities at the time of diagnosis and the impact this has on overall survival (OS). [NT1] The Cytogenetic laboratory at this hospital provides a regional service as a single facility. The data from this laboratory was combined with survival information to evaluate the impact of additional chromosomal changes on outcomes in patients with CML. Methods: This is a retrospective population based study, it was not possible to obtain consent from individual patients and details about haematolog

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8

Woyach, Jennifer A., Daphne Guinn, Amy S. Ruppert, James S. Blachly, Arletta Lozanski, Nyla A. Heerema, Weiqiang Zhao, et al. "the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL." Blood 128, no. 22 (December 2, 2016): 55. http://dx.doi.org/10.1182/blood.v128.22.55.55.

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Abstract The Bruton's Tyrosine Kinase (BTK) inhibitor ibrutinib is very effective in chronic lymphocytic leukemia (CLL). Resistance in CLL is at least in part mediated by acquired mutations in BTK or down-stream PLCG2. Here we describe the largest institutional cohort of CLL patients treated with ibrutinib, focusing on risk factors for relapse, prevalence of known resistance mutations, and development of a monitoring strategy to identify patients at risk for relapse. All 308 patients from The Ohio State University Comprehensive Cancer Center participating in 4 clinical trials of ibrutinib were

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9

Saskin, Aliza, Yulia Lin, Richard A. Wells, Martha Lenis, Alex Mamedov, Jeannie Callum, and Rena Buckstein. "Prophylactic Rh and Kell Antigen Matching Significantly Decreases Rates of Alloimmunization in Transfusion Dependent MDS Patients." Blood 124, no. 21 (December 6, 2014): 4297. http://dx.doi.org/10.1182/blood.v124.21.4297.4297.

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Abstract Background: 40-80 % of patients with myelodysplastic syndrome (MDS) become transfusion dependent during their disease course and are at risk for the development of alloimmunization. Red blood cell (RBC) alloantibodies can make finding compatible blood for transfusion more difficult, expensive and time consuming. Allommunization rates of approximately 30-47% have been reported in patients with sickle cell disease and the transfusion of RBCs prophylactically matched for Rh antigens E and C, and K antigens reduced the rate of alloimmunization from 3% to 0.5% per unit (Vichinsky et al, 20

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10

Girnius, Saulius K., Habte A. Yimer, Stephen J. Noga, Sudhir Manda, Roger M. Lyons, Kimberly Bogard, Presley Whidden, et al. "In-Class Transition (iCT) from Parenteral Bortezomib to Oral Ixazomib Proteasome Inhibitor (PI) Therapy Increases the Feasibility of Long-Term PI Treatment and Benefit for Newly Diagnosed Multiple Myeloma (NDMM) Patients in an Outpatient Setting: Updated Real-World Results from the Community-Based United States (US) MM-6 Study." Blood 136, Supplement 1 (November 5, 2020): 2–4. http://dx.doi.org/10.1182/blood-2020-140482.

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Background Long-term PI-based treatment is associated with improved outcomes in MM. Nonetheless, prolonged therapy with parenteral PIs (e.g. bortezomib) can be challenging in the real world, with median duration of therapy (DOT) of 4-7 months. Barriers to this long-term approach may include the burden of repeated intravenous/subcutaneous administration, difficulty travelling to/accessing treatment centers (e.g. due to environmental factors, travel restrictions, social/family situations), patient preference for treatment outside of a hospital or clinic setting, comorbidities, and toxicity. The

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11

Siva, Nayanah. "US stem cell climate improves, raising concerns elsewhere." Nature Medicine 15, no. 3 (March 2009): 224. http://dx.doi.org/10.1038/nm0309-224a.

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12

McClelland, Sarah E. "Single-cell approaches to understand genome organisation throughout the cell cycle." Essays in Biochemistry 63, no. 2 (May 15, 2019): 209–16. http://dx.doi.org/10.1042/ebc20180043.

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Abstract Mammalian genomes are ordered at several scales, ranging from nucleosomes (beads on a string), to topologically associated domains (TADs), laminar associated domains (LADs), and chromosome territories. These are described briefly below and we refer the reader to some recent comprehensive reviews on genome architecture summarising the current state of knowledge of the organisational principles of the nucleus [1,2]. Biological observations from populations of millions of individual cells can reveal consensus behaviour. New methods to study and interpret biological data at the single-cel

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13

Doi, Hiroshi, and Misako Kawakami. "Purification of aminopeptidase from Australian classified barley flour." International Journal of Biochemistry & Cell Biology 29, no. 2 (February 1997): 345–52. http://dx.doi.org/10.1016/s1357-2725(96)00094-5.

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14

Williams, R. J. P. "The history of proton-driven ATP formation." Bioscience Reports 13, no. 4 (August 1, 1993): 191–212. http://dx.doi.org/10.1007/bf01123502.

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This article sets down the beginnings of some thoughts in bio-energetics. It illustrates how difficult it is in science as elsewhere to know how a new idea is generated. The literature needs very careful examination and separation from personalities.

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15

Miyazaki, Kana, Motoko Yamaguchi, Hiroshi Imai, Tohru Kobayashi, Satoshi Tamaru, Kazuhiro Nishii, Masao Yuda, Hiroshi Shiku та Naoyuki Katayama. "Gene expression profiling of peripheral T-cell lymphoma including γδ T-cell lymphoma". Blood 113, № 5 (29 січня 2009): 1071–74. http://dx.doi.org/10.1182/blood-2008-07-166363.

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Abstract The gene expression profile of peripheral γδ T-cell lymphoma (γδTCL) has not been investigated. Using oligonucleotide microarrays, we analyzed total RNA from 7 patients with γδTCL (4 hepatosplenic, 1 cutaneous, 1 intestinal, and 1 thyroidal) and 27 patients with αβTCL (11 peripheral TCL-unspecified, 15 angioimmunoblastic TCL, and 1 hepatosplenic). Unsupervised microarray analyses classified all hepatosplenic γδTCLs into a single cluster, whereas other γδTCLs were scattered within the αβTCL distribution. We identified a T-cell receptor signature gene set, which accurately classified γδ

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16

Benga, Gheorghe, Victor Ioan Pop, Octavian Popescu, Ileana Benga, and William Ferdinand. "Amino acid composition of band 3 protein from red blood cells of normal and epileptic children." Bioscience Reports 11, no. 1 (February 1, 1991): 53–57. http://dx.doi.org/10.1007/bf01118605.

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Amino acid analyses of the band 3 protein purified from erythrocyte membranes of control and epileptic children showed that no major structural abnormalities of this protein could be linked with the red blood cell membrane alterations previously described in child epilepsy and, consequently, the molecular basis of these alterations should be looked for elsewhere.

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17

Yawalkar, Nikhil, Katalin Ferenczi, David A. Jones, Keiichi Yamanaka, Ki-Young Suh, Sarah Sadat, and Thomas S. Kupper. "Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma." Blood 102, no. 12 (December 1, 2003): 4059–66. http://dx.doi.org/10.1182/blood-2003-04-1044.

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Abstract Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T cells. A major feature of CTCL is profound immunosuppression, such that patients with advanced mycosis fungoides or Sézary syndrome have been compared with patients with advanced HIV disease and are susceptible to opportunistic infection. The etiology of this immunosuppression is unclear. We analyzed peripheral blood T cells of patients with CTCL with stage I to IV disease, using a sensitive beta-variable complementarity-determining region 3 spectratyping approach. Our data revealed a profound disruption of the complex

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18

Campbell, I. D. "Modular proteins at the cell surface." Biochemical Society Transactions 31, no. 6 (December 1, 2003): 1107–14. http://dx.doi.org/10.1042/bst0311107.

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Many proteins, including cell-surface receptors, extracellular matrix (ECM) proteins and intracellular signalling systems, are constructed from a relatively small number of domains or modules. Modularity provides biological systems with a convenient way of presenting binding sites on a stable protein scaffold, in the correct position for function; it also allows regulation by module rearrangement. Knowledge about modular proteins is increasing rapidly because of good databases and more systematic approaches to protein expression and structure determination. There have been a number of importan

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19

Dahlbäck, Björn. "Factor V Leiden and the genetics of myocardial infarction: we need to look elsewhere." Blood 100, no. 3 (August 1, 2002): 742. http://dx.doi.org/10.1182/blood-2002-06-1713.

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20

Hagiwara, Shotaro, Yoshinari Suzuki, Akihiro Nakayama, Akihiro Matsunaga, Yutaka Iida, and Mari Shimura. "Multiple Elements Classified Hematological Malignancies from Healthy Population." Blood 124, no. 21 (December 6, 2014): 5959. http://dx.doi.org/10.1182/blood.v124.21.5959.5959.

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Abstract Introduction It is a little known about how multiple elements interacts and functions in cells, although a specific element had already reported to take a role, enzymatic, transcriptional activities, etc. Although, several metals such as cadmium, nickel, lead, and chrome were known as carcinogen, it is also not known about relations of multiple elements in disease mechanisms. To investigate the impact of multiple elements on the features of hematological malignancies, we analyzed the multiple elements in the serum of patients with hematological malignancies and healthy persons. Method

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21

Dalton, WT Jr, MJ Ahearn, KB McCredie, EJ Freireich, SA Stass, and JM Trujillo. "HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3." Blood 71, no. 1 (January 1, 1988): 242–47. http://dx.doi.org/10.1182/blood.v71.1.242.242.

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Abstract The leukemia from which the human cell line HL-60 was derived was classified in 1976 as acute progranulocytic leukemia (APL), although it was recognized to show a number of atypical features. In the ensuing 10 years, the concept of APL and its integral association with t(15;17) has evolved, and the concept of APL as a morphologically recognizable entity has become embodied in the term French-American-British classification M3 (FAB-M3). It is now recognized that not every case of leukemia with a high proportion of progranulocytes can be classified as FAB-M3. We reviewed the light and u

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Dalton, WT Jr, MJ Ahearn, KB McCredie, EJ Freireich, SA Stass, and JM Trujillo. "HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3." Blood 71, no. 1 (January 1, 1988): 242–47. http://dx.doi.org/10.1182/blood.v71.1.242.bloodjournal711242.

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The leukemia from which the human cell line HL-60 was derived was classified in 1976 as acute progranulocytic leukemia (APL), although it was recognized to show a number of atypical features. In the ensuing 10 years, the concept of APL and its integral association with t(15;17) has evolved, and the concept of APL as a morphologically recognizable entity has become embodied in the term French-American-British classification M3 (FAB-M3). It is now recognized that not every case of leukemia with a high proportion of progranulocytes can be classified as FAB-M3. We reviewed the light and ultrastruc

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23

Harayama, S., and M. Rekik. "Bacterial aromatic ring-cleavage enzymes are classified into two different gene families." Journal of Biological Chemistry 264, no. 26 (September 1989): 15328–33. http://dx.doi.org/10.1016/s0021-9258(19)84830-5.

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24

Noguchi, Taro Q. P., Yuki Gomibuchi, Kenji Murakami, Hironori Ueno, Keiko Hirose, Takeyuki Wakabayashi, and Taro Q. P. Uyeda. "Dominant Negative Mutant Actins Identified in FlightlessDrosophilaCan Be Classified into Three Classes." Journal of Biological Chemistry 285, no. 7 (November 21, 2009): 4337–47. http://dx.doi.org/10.1074/jbc.m109.059881.

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25

Dimopoulos, Meletios A., Lia A. Moulopoulos, Alice Maniatis, and Raymond Alexanian. "Solitary plasmacytoma of bone and asymptomatic multiple myeloma." Blood 96, no. 6 (September 15, 2000): 2037–44. http://dx.doi.org/10.1182/blood.v96.6.2037.

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Abstract Most patients with multiple myeloma (MM) present with symptoms, have evidence of generalized disease, and require chemotherapy promptly to reduce the malignant clone. Some patients present with a local symptom from a single plasmacytoma but no myeloma elsewhere. Such patients usually become free of symptoms after local radiotherapy. In patients with MM without symptoms, the diagnosis is made on the basis of screening laboratory tests. In patients with either solitary plasmacytoma of bone or asymptomatic MM, systemic treatment should be deferred until there is evidence of disease progr

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Dimopoulos, Meletios A., Lia A. Moulopoulos, Alice Maniatis, and Raymond Alexanian. "Solitary plasmacytoma of bone and asymptomatic multiple myeloma." Blood 96, no. 6 (September 15, 2000): 2037–44. http://dx.doi.org/10.1182/blood.v96.6.2037.h8002037_2037_2044.

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Most patients with multiple myeloma (MM) present with symptoms, have evidence of generalized disease, and require chemotherapy promptly to reduce the malignant clone. Some patients present with a local symptom from a single plasmacytoma but no myeloma elsewhere. Such patients usually become free of symptoms after local radiotherapy. In patients with MM without symptoms, the diagnosis is made on the basis of screening laboratory tests. In patients with either solitary plasmacytoma of bone or asymptomatic MM, systemic treatment should be deferred until there is evidence of disease progression.

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Yamasaki, Masayuki, Satoko Moriwaki, Osamu Miyake, Wataru Hashimoto, Kousaku Murata, and Bunzo Mikami. "Structure and Function of a HypotheticalPseudomonas aeruginosaProtein PA1167 Classified into Family PL-7." Journal of Biological Chemistry 279, no. 30 (May 10, 2004): 31863–72. http://dx.doi.org/10.1074/jbc.m402466200.

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28

Worrillow, Lisa, Sharon Barrans, Simon Crouch, Matthew Care, Alex Smith, Russell Patmore, Reuben Tooze, Eve Roman, and Andrew Jack. "RQ-PCR Provides a Superior Alternative to Immunohistochemistry In Defining Prognostic Groups In DLBCL, and Predicts Treatment Failure with CHOP-R." Blood 116, no. 21 (November 19, 2010): 2484. http://dx.doi.org/10.1182/blood.v116.21.2484.2484.

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Abstract Abstract 2484 Diffuse large B cell lymphoma (DLBCL) is a heterogenous disease, which has been subclassified into germinal centre (GCB) and activated B-cell (ABC) type using gene expression profiling. This has been shown to separate DLBCL into distinct prognostic sub-groups in patients treated with either CHOP or CHOP-R therapy. A number of published immunohistochemistry algorithms have attempted to replicate this subclassification using a limited number of markers, however, despite being widely adopted, the reproducibility of the algorithms has proven difficult, possibly due to the su

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29

Trautmann, Heiko, Anastasia Hadzidimitriou, Nikos Darzentas, Wolfram Klapper, Reiner Siebert, Hilmar Berger, Monika Szczepanowski, et al. "Evidence for Antigen-Driven Development of Molecularly Classified Burkitt Lymphomas." Blood 114, no. 22 (November 20, 2009): 317. http://dx.doi.org/10.1182/blood.v114.22.317.317.

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Abstract Abstract 317 Evidence for Antigen-driven Development of Molecularly Classified Burkitt Lymphomas The presence of somatic mutations and intraclonal diversity (ID) in the variable region of rearranged immunoglobulin (Ig) genes is commonly used as a marker of the cellular passage of B cells through the germinal center (GC) reaction in secondary lymphoid tissues following an in vivo antigen encounter. Such features have also been documented in different subgroups of aggressive B-cell lymphomas, suggesting that antigen selection pressure has taken place during lymphoma development. We unde

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30

CLARKSON, Joanna, Iain D. CAMPBELL, and Michael D. YUDKIN. "Phosphorylation induces subtle structural changes in SpoIIAA, a key regulator of sporulation." Biochemical Journal 372, no. 1 (May 15, 2003): 113–19. http://dx.doi.org/10.1042/bj20021748.

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The phosphorylation state of SpoIIAA is a key factor in the regulation of sporulation in Bacillus subtilis. Previous crystallographic studies had led to the conclusion that phosphorylation alters the binding affinity of SpoIIAA for its partner proteins solely through the additional charge and bulk of the phosphoryl group: small structural changes observed elsewhere in the protein were considered to be random fluctuations rather than the result of phosphorylation. The results presented in the present paper show that NMR studies detect the same subtle structural changes in solution as those seen

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31

De Salvo Cardullo, Luigi, Mirian C. Duerto, Dalila DV De Salvo, Rodolfo J. Salas-A, Jesus E. Weir-M, Ana M. Nuñez, Alonso A. Nuñez, et al. "Differential Diagnosis of Myelodisplastic Syndrome, with Flow Cytometry." Blood 114, no. 22 (November 20, 2009): 4860. http://dx.doi.org/10.1182/blood.v114.22.4860.4860.

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Abstract Abstract 4860 Our flow cytometry laboratory processed 38 bone marrow (BM) samples (24 males and 14 females) from patients with Myelodisplasic Syndrome diagnosis, from January 2008 to May 2009. Upon examination, most BM smears corresponded with an hypercellular bone marrow and increased intermediate and immature cells. All patients classified according to OMS for Myelodisplasic Syndromes. Twenty-four (n=24) patients (65%) presented RA, five (n=5) patients (13%) RAEB-1, one (n=1) 1% presented RARS, and eight (n=8) patients (21%) classified as RAEB-II. Cytogenetic result analyses for all

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Carey, Christopher Daniel, Daniel Gusenleitner, Zhang Xuan, Aliyah R. Sohani, Olga Weinberg, Hongbo Yu, Ben Chen, et al. "Resolving the Biological Heterogeneity of B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between DLBCL and BL (BCL-U) Using Quantitative Profiles of Oncogenic Signaling Networks." Blood 126, no. 23 (December 3, 2015): 3903. http://dx.doi.org/10.1182/blood.v126.23.3903.3903.

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Abstract BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) have characteristic cellular, phenotypic, and genetic characteristics that reflect their distinctive biology. These distinctions are attributable, in part, to differential activity of defined oncogenic signaling pathways, including TCF3/ID3, NFkB, MYC, and BCL2 (Carey et al, JMD, 2015). B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL (BCL-U) encompasses a group of tumors with ambiguous features and likely heterogeneous biology. We used targeted gene expression profiling and a m

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33

Fisher, RI, S. Dahlberg, BN Nathwani, PM Banks, TP Miller, and TM Grogan. "A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study." Blood 85, no. 4 (February 15, 1995): 1075–82. http://dx.doi.org/10.1182/blood.v85.4.1075.bloodjournal8541075.

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The objectives of this study were (1) to determine the clinical presentation and natural history associated with two newly recognized pathologic entities termed mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL), including the mucosa-associated lymphoid tissue (MALT) and monocytoid B-cell subcategories, and (2) to determine whether these entities differ clinically from the other relatively indolent non- Hodgkin's lymphomas with which they have been previously classified. We reviewed the conventional pathology and clinical course of 376 patients who had no prior therapy; had stage III/

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Megeney, Lynn A., and Michael A. Rudnicki. "Determination versus differentiation and the MyoD family of transcription factors." Biochemistry and Cell Biology 73, no. 9-10 (September 1, 1995): 723–32. http://dx.doi.org/10.1139/o95-080.

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The myogenic regulatory factors (MRFs) form a family of basic helix–loop–helix transcription factors consisting of Myf-5, MyoD, myogenin, and MRF4. The MRFs play key regulatory roles in the development of skeletal muscle during embryogenesis. Sequence homology, expression patterns, and genetargeting experiments have revealed a two-tiered subclassification within the MRF family. Myf-5 and MyoD are more homologous to one another than to the others, are expressed in myoblasts before differentiation, and are required for the determination or survival of muscle progenitor cells. By contrast, myogen

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35

Zimring, James C. "Established and theoretical factors to consider in assessing the red cell storage lesion." Blood 125, no. 14 (April 2, 2015): 2185–90. http://dx.doi.org/10.1182/blood-2014-11-567750.

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AbstractThe collection and storage of red blood cells (RBCs) is a logistical necessity to provide sufficient blood products. However, RBC storage is an unnatural state, resulting in complicated biological changes, referred to collectively as the “storage lesion.” Specifics of the storage lesion have been studied for decades, including alterations to cellular properties, morphology, molecular biology of carbohydrates, proteins and lipids, and basic metabolism. Recently, mass spectrometry–based “omics” technology has been applied to the RBC storage lesion, resulting in many new observations, the

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Tang, Xuemei, Peng Gu, and Wenming Lu. "A rare case of adult colocolic intussusception secondary to splenosis." Journal of International Medical Research 50, no. 8 (August 2022): 030006052211153. http://dx.doi.org/10.1177/03000605221115386.

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Intussusception is the invagination of a segment of bowel (intussusceptum) into the lumen of an adjacent segment (intussuscipiens). Adult intussusception is rare and typically asymptomatic, although bowel obstruction can be a predominant symptom, making it difficult to diagnose. Splenosis is an uncommon and benign disease, arising from the self-implantation of splenic tissue elsewhere in the body after splenectomy or splenic trauma. Colocolic intussusception secondary to splenosis is rare. We report a case of colon intussusception with a mass in the intussusception detected by ultrasound. Abdo

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Nickel, Robert Sheppard, Elizabeth Seashore, Adina L. Alazraki, John T. Horan, Monica Bhatia, and Ann E. Haight. "Improved Splenic Function after Stem Cell Transplant for Sickle Cell Disease." Blood 124, no. 21 (December 6, 2014): 3966. http://dx.doi.org/10.1182/blood.v124.21.3966.3966.

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Abstract Introduction: Splenic dysfunction is a critical complication of SCD that begins in early childhood and can cause fatal sepsis. Hematopoietic stem cell transplant (HSCT) is a proven cure for SCD, however, its long-term effect on the spleen in patients who had SCD is not well characterized. This information could be helpful to further inform medical professionals and families considering HSCT for SCD. Better understanding of the splenic function of patients after transplant for SCD could also provide important information regarding these patients' future risk of infection and other poss

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Poudyal, Hemant, and Lindsay Brown. "Should the pharmacological actions of dietary fatty acids in cardiometabolic disorders be classified based on biological or chemical function?" Progress in Lipid Research 59 (July 2015): 172–200. http://dx.doi.org/10.1016/j.plipres.2015.07.002.

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Barron, Michelle A., Neil Fishman, G. Mark Baillie, and Helga Brake. "Multicenter Evaluation of Fungal Prophylaxis in Hematopoietic Stem Cell Transplantation." Blood 108, no. 11 (November 16, 2006): 5293. http://dx.doi.org/10.1182/blood.v108.11.5293.5293.

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Abstract BACKGROUND: The University HealthSystem Consortium (UHC) conducted a benchmarking study to assess members’ compliance with published guidelines for prevention of fungal infections in hematopoietic stem cell transplant (HSCT) recipients. METHODS: Adult HSCT patients were evaluated by retrospective chart review of cases discharged between 01/01/04 and 06/30/05. Data collected included demographics, use of prophylaxis (px), and outcomes. Patients were classified as high or low risk for fungal infection according to NCCN and CDC guidelines. RESULTS: Thirteen UHC member hospitals submitted

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40

MONJUSHO, Hatsumi, Nozomu OKINO, Motohiro TANI, Mineko MAEDA, Motonobu YOSHIDA, and Makoto ITO. "A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum." Biochemical Journal 376, no. 2 (December 1, 2003): 473–79. http://dx.doi.org/10.1042/bj20030652.

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Ceramidases (CDases) are currently classified into three categories (acid, neutral and alkaline) based on their optimal pHs and primary structures. Here, we report the first exception to this rule. We cloned the CDase cDNA, consisting of 2142 nucleotides encoding 714 amino-acid residues, from the slime mould, Dictyostelium discoideum. The putative amino-acid sequence indicates 32–42% identity with various neutral CDases, but does not show any similarity to the acid and alkaline CDases, indicating the enzyme should be classified as a neutral CDase. However, overexpression of the cDNA in D. disc

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41

Makishima, Hideki, Kenichi Yoshida, Thomas LaFramboise, Bartlomiej P. Przychodzen, Matthew Ruffalo, Inés Gómez-Seguí, Yuichi Shiraishi, et al. "In Analogy to AML, MDS Can be Sub-Classified By Ancestral Mutations." Blood 124, no. 21 (December 6, 2014): 823. http://dx.doi.org/10.1182/blood.v124.21.823.823.

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Abstract Somatic mutations constitute key pathogenetic elements in MDS. Unbiased whole exome sequencing (WES) and deep NGS led to discovery of new somatic mutations and also to the recognition of i) tremendous diversity of mutations and their combinations; ii) individual intra-tumor heterogeneity and clonal hierarchy. Chromosomal lesions further increase the complexity of molecular defects. While in MDS molecular defects are acquired in order, observations made in AML highlight the importance of ancestral events; e.g., t(8;21), inv16 or t(15;17) and other lesions that are used as the basis for

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42

Moller, P., G. Moldenhauer, F. Momburg, B. Lammler, M. Eberlein-Gonska, S. Kiesel, and B. Dorken. "Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation." Blood 69, no. 4 (April 1, 1987): 1087–95. http://dx.doi.org/10.1182/blood.v69.4.1087.1087.

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Abstract This article reports eight primary mediastinal tumors occurring in young adults (19 to 43 years, mean 29.4 years), predominantly female (six of eight) adults. Most patients responded badly to aggressive therapy. Progression is presently noted in one patient; five patients died 10, 11, 13, 18, and 22 months after diagnosis. No patient developed leukemia. The tumors were highly proliferative, had a diffuse growth pattern, and comprised clear cells of variable size. They could not be classified histologically, but could, however, be immunohistologically characterized as B cell lymphomas.

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Moller, P., G. Moldenhauer, F. Momburg, B. Lammler, M. Eberlein-Gonska, S. Kiesel, and B. Dorken. "Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation." Blood 69, no. 4 (April 1, 1987): 1087–95. http://dx.doi.org/10.1182/blood.v69.4.1087.bloodjournal6941087.

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This article reports eight primary mediastinal tumors occurring in young adults (19 to 43 years, mean 29.4 years), predominantly female (six of eight) adults. Most patients responded badly to aggressive therapy. Progression is presently noted in one patient; five patients died 10, 11, 13, 18, and 22 months after diagnosis. No patient developed leukemia. The tumors were highly proliferative, had a diffuse growth pattern, and comprised clear cells of variable size. They could not be classified histologically, but could, however, be immunohistologically characterized as B cell lymphomas. In all c

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44

Macreadie, I., S. Sankovich, P. Failla, M. Lowe, C. Curtain, L. Castelli, and A. Azad. "HIV-1 Nef protein causes death in stressed yeast cells due to determinants near the N-terminus and elsewhere in Nef." IUBMB Life 46, no. 2 (October 1998): 277–86. http://dx.doi.org/10.1080/15216549800203792.

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45

Scott, Stuart, Richard Dillon, Christian Thiede, Sadia Sadiq, Ashley Cartwright, Clouston Hazel, Debbie Travis, Andrew D. Chantry, and Liam Whitby. "Assessment of Minimal/Measurable Residual Disease Testing in Acute Myeloid Leukaemia By Molecular Methods in an Interlaboratory Study." Blood 138, Supplement 1 (November 5, 2021): 3461. http://dx.doi.org/10.1182/blood-2021-152259.

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Abstract Background Minimal/measurable residual disease (MRD) testing is increasingly utilised and accepted as standard of care to manage a range of different haematological malignancies. It's use as a surrogate outcome in clinical trials of new therapies is being explored, where it has the potential to accelerate drug assessment and approval. The phenotypic and genetic heterogeneity of acute myeloid leukaemia (AML) has limited the use of MRD in this context; however, the European LeukaemiaNet (ELN) MRD working group have recently published consensus guidelines to standardise both flow cytomet

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46

Roston, Rebecca L., Kun Wang, Leslie A. Kuhn, and Christoph Benning. "Structural Determinants Allowing Transferase Activity in SENSITIVE TO FREEZING 2, Classified as a Family I Glycosyl Hydrolase." Journal of Biological Chemistry 289, no. 38 (August 6, 2014): 26089–106. http://dx.doi.org/10.1074/jbc.m114.576694.

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47

Rose, James D. "Corticosteroid actions from neuronal membrane to behavior: Neurophysiological mechanisms underlying rapid behavioral effects of corticosterone." Biochemistry and Cell Biology 78, no. 3 (April 2, 2000): 307–15. http://dx.doi.org/10.1139/o00-021.

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Investigation of the rapid suppression of male courtship clasping behavior by corticosterone in roughskin newts (Taricha granulosa) has led to the identification of a specific neuronal membrane receptor for this stress steroid. This paper describes studies of the neurophysiological effects of the rapid, membrane receptor mediated action of corticosterone on neurons that are involved in the control of clasping. In freely behaving newts, medullary neurons, including reticulospinal neurons, process clasp-triggering sensory signals and participate in control of clasping movements. Corticosterone i

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CORRIGAN, Douglas P., Danuta KUSZCZAK, Antonio E. RUSINOL, Douglas P. THEWKE, Christine A. HRYCYNA, Susan MICHAELIS, and Michael S. SINENSKY. "Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24." Biochemical Journal 387, no. 1 (March 22, 2005): 129–38. http://dx.doi.org/10.1042/bj20041359.

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The nuclear lamins form a karyoskeleton providing structural rigidity to the nucleus. One member of the lamin family, lamin A, is first synthesized as a 74 kDa precursor, prelamin A. After the endopeptidase and methylation reactions which occur after farnesylation of the CAAX-box cysteine, there is a second endoproteolysis that occurs 15 amino acids upstream from the C-terminal farnesylated cysteine residue. Studies with knockout mice have implicated the enzyme Zmpste24 (Face-1) as a suitable candidate to perform one or both of these proteolytic reactions. Evidence has been presented elsewhere

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De Vos, John, Dirk Hose, Thierry Reme, Hartmut Goldschmidt, Jean-Francois Rossi, Friedrich Cremer, and Bernard Klein. "The Human Plasma Cell Gene Expression Program." Blood 104, no. 11 (November 16, 2004): 3242. http://dx.doi.org/10.1182/blood.v104.11.3242.3242.

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Abstract Seven purified peripheral blood memory B-cells (BM), seven in-vitro-generated polyclonal plasmablastic cells (PPC) and seven purified bone marrow mature plasma cells (BMPC) were studied by oligonucleotide microarrays. All samples were obtained from healthy volunteers. The gene expression profiling of these samples was determined with Affymetrix pan genomic U133A + B arrays (44 928 oligonucleotide probesets). We determined that 2313 genes were differentially expressed between these three B cell categories (P 〈 0.01 by a Kruskal-Wallis test and a ratio between two categories 〉 3). These

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Gomes, Marilia, Sara Duarte, Carolina Afonso, Dulcelena Neves, Bárbara Almeida Marques, Carla Barros Lima, Adriana Roque, et al. "Prognostic Scoring Systems in Diffuse Large B Cell Lymphoma Patients - Is Kyoto Prognostic Index an Added Value?" Blood 138, Supplement 1 (November 5, 2021): 4574. http://dx.doi.org/10.1182/blood-2021-150959.

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Abstract Background: Diffuse large B cell Lymphoma (DLBCL), the most common non-Hodgkin lymphoma, is a clinical and biological heterogeneous entity. R-CHOP is the standard treatment, however 30%-40% of DLBCL patients will have primary refractory or relapsed disease. Several prognostic scoring systems, that include simple clinical parameters, have been developed to assist risk stratification and treatment decisions, namely the International Prognostic Index (IPI), the National Comprehensive Cancer Network IPI (NCCN-IPI) and the GELTAMO-IPI. However, the accurate identification of very high-risk

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