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Dissertations / Theses on the topic 'Biochemistry of glycoproteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Jefferies, W. A. "Lymphocyte surface glycoproteins." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355757.

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2

Duffy, Iain. "Analysis of measles virus glycoproteins." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324842.

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3

Wood, Sarah Louise. "Glycoproteins of the chromaffin granule membrane." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19427.

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4

Howe, T. "Biosynthesis of serum glycoproteins by isolated rat hepatocytes." Thesis, Bucks New University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371224.

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5

Burdge, Graham Charles. "Biochemical analysis of proteolytic fragments from desmosomal glycoproteins." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290426.

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6

Hemming, Richard John. "Radioautographical and biochemical studies on nucleoplasmic glycoproteins." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41298.

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EM radioautography was used to examine the tissue distribution of cells exhibiting nucleoplasmic labeling after being exposed to $ sp3$H-sugars or $ sp{35}$S-sulphate to indicate the general extent of the occurrence of nucleoplasmic glycoproteins within animal cells. The observation of some degree of such labeling in virtually all cells in tissues of three animal species suggests that nucleoplasmic glycoproteins are a common cellular feature. To better define the distribution and nature of the putative labeled nucleoplasmic glycoproteins, cultured cells were used as a model cell type for both

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7

Smith, Kevin David. "The site-specific glycosylation patterns of serum and membrane glycoproteins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315282.

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8

Brown, Vivienne Alison. "A study of cell surface glycoproteins in chronic lymphocytic leukaemia." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/12092.

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9

Zamani, Mohammad Reza. "The role of glycoproteins in neural plasticity in domestic chick." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293893.

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10

Uysal, Hamdi. "Extracellular matrix glycoproteins of skin fibroblasts in tuberous sclerosis." Thesis, University of Nottingham, 1995. http://eprints.nottingham.ac.uk/13094/.

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The first main objective of this project was to isolate cellular fibronectin from cultures of skin fibroblasts derived from tuberous sclerosis (TS) patients and normals and to compare their structures, paying particular attention to the content and pattern of carbohydrate (glycosylation). The second main objective of this project was to establish the expression and localisation of glycoproteins fibronectin, laminin and tenascin of the extracellular matrix (ECM) in cultures of skin fibroblasts derived from patients with TS and normal individuals. In order to achieve these objectives, fibroblast

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11

Craig, Sarah Jane. "The analysis of complex glycoproteins by capillary electrophoresis and mass spectrometry." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283361.

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12

Rankine, Susan M. "Changes in glycosylation on antibodies between normal patients and those with rheumatoid arthritis." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258151.

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13

Peiser, Leanne. "The role of the macrophage scavenger receptor in host defence." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393470.

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14

Youakim, Adel. "Tumour- and differentiation-associated changes in the carbohydrate structure of glycoproteins from human colonic cells." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75826.

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The structure of the carbohydrate associated with glycoproteins was examined in various human colonic tumour cells in culture following incubation with labeled sugars. Glycopeptides obtained by pronase digestion of the cell surface glycoproteins of three human colon tumours (HCT-8R, CaCo-2, and HCT-15) were compared with those from cells (CCL 239) derived normal adult colon. The tumour cells contain large molecular weight fucose-labeled glycopeptides that are absent in the CCL 239 cells. The large molecular weight fucose- and glucosamine-labeled glycopeptides from HCT-8R cells contain mainly m

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15

Ferreira, Sandra S. "Improving the rational design of antifreeze glycoproteins through identification of the parameters that influence ice recrystallization inhibition." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28336.

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Antifreeze glycoproteins (AFGPs) are a subclass of biological antifreezes isolated from Antarctic and Atlantic Teleost fish. These compounds have the ability to depress the freezing points of solutions as well inhibit ice crystal growth, thereby protecting fish from cryoinjury and death. Although native AFGPs have considerable promise as cryoprotectants, their limited bioavailability, cytotoxicity, biological instability and lengthy chemical syntheses have precluded their Widespread use. Consequently, Ben et al. have designed non-cytotoxic stable C-linked AFGPs with comparable ice recrystaliza

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16

Chen, Yuning. "Biochemical Characterization of Hydroxyproline-rich Glycoproteins in the Arabidopsis Root Cell Wall." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1352912989.

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17

Dong, Wen. "Extensin Peroxidase Identification and Characterization in Solanum lycopersicum." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1425894387.

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18

Marshall, Jocelyn R. "A Study of the Impact of Membrane Organization of Glycosphingolipid E-selectin Ligands and Glycoproteins on Head and Neck Cancer Cell Adhesion to Vascular Endothelium." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1313073422.

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19

Liang, Yan. "Identification and Characterization of Galactosyltransferases and Fucosyltransferases Involved in Arabinogalactan-Protein Glycosylation." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1343410954.

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20

Ward, J. "The biochemisry of the attatchment and release of the variant surface glycoprotein of Trypanosoma brucei brucei." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383373.

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21

Al-Kassab, A. S. K. "Glycoprotein production by human breast cancer tissue." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356554.

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22

Clark, Melanie Jane. "The structure of MRC OX-2 membrane glycoprotein." Thesis, University of Oxford, 1985. https://ora.ox.ac.uk/objects/uuid:4a98764e-7d08-4cda-a3aa-f50409c63383.

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The mouse monoclonal antibody MRC OX-2 recognises a rat cell surface glycoprotein of M<sub>R</sub> about 45,000 which is expressed on brain and lymphoid tissues. The OX-2 antigen is of interest because its tissue distribution and biochemical properties are similar to Thy-1, a cell surface antigen which is known to have a structure resembling an immunoglobulin domain. In this thesis, the structure of OX-2 antigen is determined to evaluate whether it shares sequence homology with Thy-1 and immunoglobulins. OX-2 antigen was purified from rat brain by monoclonal antibody affinity chromatography, a

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23

Chai, Wengang. "New approaches to mass spectrometric characterisation of glycoprotein oligosaccharides." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315393.

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24

Cayrol, Romain. "Study of class I and class II P-glycoprotein chimeras." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19436.

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The Multidrug drug resistance (MDR) phenotype is a major limitation to chemotherapy. The MDR phenotype arises when class I P-glycoproteins (P-gps) are overexpressed in cultured cells in vitro and in tumor cells in vivo. P-gps are encoded in rodents by three genes: mdr1, mdr2 and mdr3. Class I P-gps (Mdrl, Mdr3) confer drug resistance upon transfection in non-resistant cells and act as ATP dependent drug efflux pumps, class II P-gps (Mdr2) do not convey MDR but act as lipid flippases in the canalicular membranes of hepatocytes. P-gps are composed of twelve transmembrane domains and two nucleoti

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25

Bond, Tamara Dawn. "Volume-regulated ion channels with their interaction with P-glycoprotein." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339361.

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26

Yuahasi, Katia Kioko. "Mecanismos de formação da LDL eletronegativa (LDL-): efeito da glicoxidação e da lipólise." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-09122016-143030/.

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A fração plasmática da lipoproteína de baixa densidade (LDL) é formada por partículas de diferentes tamanhos, carga e densidade. Baseada na diferença de carga das partículas, a LDL pode ser subfracionada em LDL nativa (nLDL) e LDL eletronegativa (LDL‾). A LDL‾ está presente no plasma e possui propriedades aterogênicas e pró-inflamatórias, assim como, possui menor concentração de antioxidantes lipossolúveis, maior concentração de dienos conjugados, alterações conformacionais da apoliproteína B-100 e menor afinidade para o receptor da LDL em comparação com a nLDL. Concentrações eleva

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27

Allan, Linda M. "Studies on the surface epitopes of the Trypanosoma brucei variant surface glycoprotein." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335046.

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28

Bowers, Katherine Elisabeth. "Sorting of CD4 and the SIV envelope glycoprotein in the endocytic pathway." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286733.

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29

Spiciarich, David. "Chemical Glycoproteomics for Identification and Discovery of Glycoprotein Alterations in Human Cancer." Thesis, University of California, Berkeley, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10688096.

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<p> Changes in glycosylation have long been appreciated to be part of the cancer phenotype; sialylated glycans are found at elevated levels on many types of cancer and have been implicated in disease progression. However, the specific glycoproteins that contribute to cell surface sialylation are not well characterized, specifically in <i>bona fide</i> human cancer. Metabolic and bioorthogonal labeling methods have previously enabled enrichment and identification of sialoglycoproteins from cultured cells and model organisms. The goal of this work was to develop technologies that can be used for

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30

Keyston, Rebecca. "Homotypic and heterotypic adhesion mediated by biliary glycoprotein, BGP." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23900.

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Glycophosphatidyl-inositol (GPI)-linked carcinoembryonic antigen (CEA) family members, including CEA itself, are absent in rodents and seem to have evolved recently. We have shown previously that CEA-CEA binding required for intercellular adhesion involves a double reciprocal interaction between the N-terminal (N domain) and internal A3B3 domains of anti-parallel molecules on apposed cell surfaces. To answer the question of whether this binding mechanism also evolved with CEA, the adhesive binding mechanism for transmembrane biliary glycoprotein (BGP), presumably more primordial, was investiga

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31

Kwan, Tony 1972. "Structural and functional analysis of the mouse Mdr3 P-glycoprotein." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38069.

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Multidrug resistance in certain tumours in vivo and in cultured cells in vitro is caused by the overexpression of P-glycoprotein. Pgps are encoded by a small family of three genes in rodents (mdr1, mdr2, mdr3 ) and two in humans (MDR1, MDR2), and belong to the larger superfamily of ABC transporters, characterized by their ability to transport various substrates at the expense of ATP. Pgps are comprised of 12 transmembrane (TM) domains, some of which are involved in the binding of these drugs, and two intracellular nucleotide-binding (NB) domains that catalyze ATP hydrolysis. Communication occu

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32

Anderson, C. M. "Glycoprotein structure of components C2 and factor B of the human complement system." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375210.

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33

Rana, Tahir. "Synthesis of a C-linked antifreeze glycoprotein building block containing an internal olefin." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28186.

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Antifreeze glycoproteins (AFGPs) are polypeptide compounds found in the blood of Antarctic notothenioids and northern cod. These substances inhibit the growth and proliferation of ice in fish inhabiting sub-zero conditions. The structure of AFGPs, and the mechanism of ice growth inhibition at the molecular level have been a source of intense debate. Work in our laboratory involves the synthesis of AFGP analogues in an effort to discern the mechanism of ice growth inhibition and enhance antifreeze attributes for potential therapeutic applications. We have previously synthesized C-linked AFGP an

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34

Holdstock, Jolyon Guy. "Intracellular mechanisms mediating transcriptional regulation and secretion of the pituitary glycoprotein hormone alpha-subunit." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283413.

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35

Yule, Fiona Sara Bridget. "The correlation between the glycosylation of Alpha-1-acid glycoprotein and healing in wounds." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366836.

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36

Minuk, Jeffrey. "Studies on the intracellular sorting of the two myelin-associated glycoprotein isoforms." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23414.

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Myelin-associated glycoprotein (MAG) is amongst the earliest expressed myelin specific proteins. Its precise function remains unknown, though evidence supports a role for cell-cell adhesion. MAG may also act as a spacer molecule and could be involved in signal transduction. MAG is expressed as two isoforms, designated as L-MAG and S-MAG. Both share identical extracellular and transmembrane domains but differ in their cytoplasmic domains. L-MAG is expressed earlier during myelination than S-MAG. These features, as well as others, suggest that the isoforms have different functions. To confirm th

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37

Schiffner, Torben. "Refocusing antibody responses by chemical modification of vaccine antigens." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2b2cac0f-6be3-4f91-96e5-9888e02780d4.

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The envelope glycoprotein (Env) of Human Immunodeficiency Virus 1 (HIV-1) has developed several immune-evasion mechanisms to avoid the induction of neutralising antibodies, including immunodominant non-neutralising epitopes, conformational flexibility of conserved epitopes, and spontaneous subunit dissociation, thus impeding vaccine development. Here, chemical modification of Env-based vaccine antigens is explored to overcome these obstacles. Firstly, covalent fixation of Env by chemical cross-linking was used to stabilise the conformationally flexible structure and prevent subunit dissociatio

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38

Vilela, Marcelo Jose. "Monoclonal antibodies to desmosomal glycoprotein 1 : their contribution to cancer diagnosis and protein structure studies." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280459.

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39

Shell, Elizabeth. "Chemical Unfolding and Macromolecular Crowding of Alpha-1-Acid Glycoprotein." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1115047649.

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40

Hieber, A. David (Andrew David) 1966. "Characterisation of glycoprotein II from bovine adrenal medulla." Thesis, University of Auckland, 1993. http://hdl.handle.net/2292/1988.

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Glycoprotein II (GpII) is a glycoprotein isolated from the membranes of chromaffin granules in the adrenal medulla. The chromaffin granules of the adrenal medulla are responsible for the biosynthesis, storage and secretion of catecholamines, neuropeptides and various proteins. The abundance of chromaffin granules makes them an excellent model to further study the organelles specialized in the synthesis and secretion of hormones and neurotransmitters, from both endocrine and synaptic vesicles. When viewed by two-dimensional electrophoresis GpII is a heterogeneoug glycoprotein (80000-100000 dalt

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41

Dahabiyeh, Lina. "Targeted mass spectrometry for plasma glycoprotein profiling in pre-eclampsia." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35445/.

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Pre-eclampsia is a common hypertensive disorder of pregnancy that substantially affects maternal and neonatal morbidity and mortality worldwide. Despite decades of research, the aetiology of the disease remains poorly understood, and the clinical management of it is hampered by the lack of reliable diagnostic tests and effective therapy. Several screening tests have been suggested for the prediction of preeclampsia; however, none possess the sufficient specificity and sensitivity. Moreover, multiple pathways are known to be involved in the pathogenesis of pre-eclampsia, so it is very unlikely

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42

Pereira, Elisângela Monteiro. "Modificação induzida por β2-glicoproteína I na resposta oxidativa de polimorfonucleares humanos durante a fagocitose." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-11012018-141639/.

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β2-glicoproteína I (β2GPI) é encontrada (200µg/mL) no plasma, 60% livre e 40% em lipoproteínas. Esta proteína de fase aguda, com afinidade por superfícies negativas pode ser clivada pela plasmina. Fragmentos são purificados como dímeros ou multímeros de β2GPI. Formas monomérica e dimérica de β2GPI foram purificadas de soro humano e identificadas por SDS-PAGE, imunoblot e ELISA Somente a forma monomérica foi detectada no teste ELISA Os efeitos de ambas as formas sobre o burst respiratório de polimorfonucleares humanos (PMN), estimulados in vitro com zymosan opsonizado,

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43

McNally, Tracy Jane. "An investigation of the role of antiphospholipid antibodies and #beta#2 glycoprotein-I in the modulation of haemostasis." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339151.

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44

Wand, Nadina Ivanova. "Variant surface glycoprotein synthesis and cell cycle progression in Trypanosoma brucei." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:01bbdf34-8cb3-4942-a14d-d6ba3a3e669d.

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The unicellular eukaryote Trypanosoma brucei causes African Sleeping sickness and multiplies extracellularly in the bloodstream of the infected host. The parasite evades antibody-mediated lysis by switching its Variant Surface Glycoprotein (VSG) coat. Blocking VSG synthesis results in an abrupt growth inhibition and a precise pre-cytokinesis cell cycle arrest, with an accumulation of cells with two nuclei and two kinetoplasts. Additionally, induction of VSG RNAi triggers a global block in translation, which is not due to a general decrease in transcript levels. The mechanism behind this transl

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45

Tomotani, Ester Junko. "Imobilização da invertase em resina de troca iônica (tipo Dowex®): seu uso na modificação da sacarose." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-16082017-104536/.

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A invertase comercial (Bioinvert®) foi imobilizada por adsorção em resinas aniônicas do tipo Dowex® [1x8:50-400, 1x4:50-400 e 1x2:100-400, todos copolímeros estireno-divinilbenzênicos, porém de granulometria (50-400 mesh) e quantidades de ligações cruzadas diferentes (2-8%)] em meio aquoso. A melhor percentagem de adsorção da invertase nas resinas foi observada em pH 5,5 a 32°C, tendo o complexo Dowex®1x4-200/lnvertase apresentado índice de adsorção e coeficiente de imobilização iguais a 100%. Os parâmetros cinéticos e termodinâmicos foram determinados para a invertase solúvel e insolúvel de B

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46

Rodríguez, Torrecillas Ivan 1979. "Molecular basis to human P-glycoprotein reversion." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/586099.

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ABC (ATP-binding cassette) transporters are involved in translocate a wide spectrum of molecules across the lipid bilayer and some of them are associated with various diseases. They also have an important role in multidrug resistance (MDR) in cancer, which has been a major obstacle in cancer chemotherapy and in the treatment of leishmaniasis. While diverse transporters may confer MDR phenotype in bacteria, in human it is mainly achieved by five ABC proteins, among them P-glycoprotein/(ABCB1). To understand the structural basis of P-gp inhibitory activity, to determine the ligand bindi

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47

Fallahi, Firouzeh. "Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26898.

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Rabies virus, a negative sense single-stranded RNA virus, is the type member of the genus Lyssavirus of the Rhabdoviridae . The glycoprotein (G), which projects from the surface of the lyssavirus particle, is the only protein known to be capable of eliciting the production of neutralizing antibodies and knowledge of the antigenic nature of this protein is therefore important. Five different antigenic sites have been mapped on the G protein. In this study, the isolation of mutants resisting antibody neutralization (escape mutants) was attempted by a selection strategy employing three distinct s

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48

Powell, Kevin F. H. (Kevin Frederick Herbert). "Gene sequencing and in vitro synthesis of the rotavirus non-structural glycoprotein." Thesis, University of Auckland, 1986. http://hdl.handle.net/2292/2385.

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1. Recombinant DNA techniques have been applied to the dsRNA genome of the bovine rotavirus Nebraska Calf Scours Diarrhoea virus (NCDV). The sequence of a full - length cloned copy of genomic segment 10 of NCDV has been determined using the Sanger dideoxynucleoside sequencing technique by subcloning cDNA into M13 vectors. 2. Genomic segment 10 codes for the non-structural protein NCVP5, a protein which appears to be involved in virus maturation (Estes et al., 1983). Determination of the nucleic acid sequence of the gene has enabled the amino acid sequence o f the bovine NCVPS protein to be inf

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49

De, Champlain Annick. "Study of the key residues in close proximity to the ATP molecule in the nucleotide binding domains of P-glycoprotein by cysteine scanning mutagenesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80249.

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The three dimensional structure of P-gp nucleotide binding sites is unknown but a high resolution crystal structure was solved for the homodimer of HiSP, the ATP binding subunit of the bacterial ABC transporter histidine permease. The main goal was to test the hypothesis that the nucleotide binding domains (NBD) of P-gp are structurally and functionally conserved with HisP with respect to key residues in intimate contact with the ATP molecule and possibly involved in catalysis. The strategy adopted involves the insertion of cysteine residues at the desired position in a cysteine-less pr

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50

Ma, Jerome H. Y. "Atomistic studies of the dynamics of P-glycoprotein and its ligands." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e2e2bbe0-d4ae-4351-b339-c8e02ef3d3d9.

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A signifficant obstacle facing the healthcare industry is the phenomenon of multidrug resistance (MDR) in which a cell acquires simultaneous resistance to many unrelated drugs that it has never been exposed to. At the molecular level, MDR can be characterised by a reduction of intracellular drug levels due to their active efflux by multidrug transporters such as P-glycoprotein (Pgp). Pgp is able to efflux a phenomenally wide variety of chemically unrelated drugs and causal relationships have been established between its expression and the acquisition of MDR to numerous anticancer and central n

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