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Dissertations / Theses on the topic 'Biochemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Suttisansanee, Uthaiwan. "Biochemistry in Bacterioferritin." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2983.

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Bacterioferritin, an iron storage protein having a 24-subunit quaternary structure, was used as a model for the study of host-guest interactions and guest encapsulation, making use of its spherical cage-like structure. A hexahistidine-affinity tag fused to the C-terminus of each bacterioferritin subunit was constructed. The C-terminus of each subunit points toward the inside of the cavity, while the N-terminus is exposed on the surface of the protein. The hexaHistag was able to form strong interactions with a nickel-nitrilotriacetic acid linked dye molecule (guest) and this interactio

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2

Hoh, Hon Bing. "Biochemistry of keratoconus." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266879.

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3

Chen, Xiaoren. "Biochemistry of Prox1 function /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 160 p, 2007. http://proquest.umi.com/pqdweb?did=1456284231&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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4

Rix, Louise Katharine. "Biochemistry of heart disease." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334889.

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5

Chapman, A. "Biochemistry of Trichomonas vaginalis." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373578.

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6

Lawrence, Fiona Jane. "The biochemistry of keratoconus." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268784.

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7

Beacham, Tracey. "Biochemistry of transgenic wheats." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55160/.

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This investigation uses transgenic wheat lines carrying the <italic> Pisum sativum</italic> glycerol 3-phosphate acyl transferase gene and /or the <italic>Arabidopsis thaliana</italic> acyl ACP thioesterase gene to determine their role of these genes in producing the altered metabolic and physiological traits seen in wild type plants grown under enhanced greenhouse conditions. We identified and analysed lines with insertions of the lipid metabolism genes. Plant lines bombarded with the same transgenes, showed a huge diversity in genotypes and demonstrated the haphazard nature of particle bomba

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8

Huang, Po-Ssu Rees Douglas C. "Biochemistry and molecular biophysics /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-06012004-214823.

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9

Woodhouse, Jennifer Ann. "Plutonium pharmacokinetics and blood biochemistry." Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/20148/.

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Since its discovery in the early 1940s the element plutonium has been seen by mankind as both an opportunity and a threat. As a radioactive nuclide plutonium presents health hazards in its handling and if mankind is to make the most of this element's potential benefits it is essential that these hazards be understood. Both overestimation and underestimation of these hazards are damaging to its proper utilisation. Many studies have been carried out to determine the effects of plutonium exposure and a broad picture of the biological behaviour of plutonium has been built up. Radiological protecti

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10

Nasir-ud-Din. "Glycoconjugate biochemistry : structure-function relationship." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/27105.

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In this thesis studies on the following glycoconjugates are presented: bacterial, <I>Micrococcus lysodeikticus, </I>cell wall, simian cervical mucin, human pulmonary mucin, bovine gallbladder mucin, sperm surface glycoproteins and glycoconjugates of malarial parasite, <I>Plasmodium falciparum. </I>The information obtained on the structure of these complex carbohydrates utilising chemical, enzymatic, immunological and physical methods provided insight into the understanding, in particular, of structure-function relationship, degradation and biosynthesis of these macromolecules. Studies on model

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11

Locklin, Rachel M. S. "Biochemistry of bone cell differentiation." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363755.

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12

Davis, Jason John. "Fullerene biochemistry and surface investigations." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244592.

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13

Parker, David Alan. "Metabonomic studies in nutritional biochemistry." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500322.

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14

Wehrfitz, Josa-Marie. "The biochemistry of heterotrophic nitrification." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318038.

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15

Springer, Sebastian Hartmut. "The biochemistry of antigen presentation." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:34d1afd2-fafc-4732-8e43-e00dcd8460d1.

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This thesis describes studies on the binding of peptides to the murine major histocompatibility complex (MHC) class I molecule H-2D<sup>b</sup> (D<sup>b</sup>). The expression of the recombinant soluble D<sup>b</sup> molecule in Chinese hamster ovary cells and its subsequent purification by nickel affinity chromatography, gel filtration, and preparative native isoelectric focusing are reported. The product is the correct molecule, homogeneous, a dimer of dimers, and free of endogenous peptide. A novel binding assay based on the enhancement of natural tryptophan fluorescence by the binding of p

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16

Vuillard, Laurent Michel Marie. "The biochemistry of connective tissue." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19376.

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17

Yap, Ivan Kok-Seng. "Integrated metabonomic studies in liver biochemistry." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/8902.

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18

Song, Jina. "Coagulation factor V : pathology and biochemistry." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5595.

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ROLE OF GLU96, ASP1O2 AND ASP111 IN FACTOR V Coagulation factor V activity is unmasked by thrombin-mediated excision of the central B domain resulting in a noncovalent heterodimer, factor Va. To understand the role of individual amino acids in maintaining the Ca²⁺-depenadent subunit interaction, G1u96 (E96A), Asp1O2 (D1O2A) or Asp111 (D111A) were mutated because of known effects on chelator sensitivity. The primary clotting activity of each mutant was reduced by “40%. Demonstrating at least two distinct inhibition mechanisms, only D111A was further inhibited by thrombin pre-treatment consisten

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19

Nabbs, Brent Kenneth. "The chemistry and biochemistry of hydroxymethylpyrroles." Thesis, University of Canterbury. Chemistry, 1999. http://hdl.handle.net/10092/7302.

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This thesis examines the chemistry and biochemistry of hydroxyrnethylpyrroles of the type 1.9 (X = OH). Pyrrolic compounds play an important role in many areas of chemistry and biology. A large number of biomolecules which are essential for life are derived from simple pyrrole precursors, eg porphyrins and haemoglobin. In addition, pyrroles have been utilised as building blocks and key intermediates in synthesis. Chapter One gives a general introduction to the biological, chemical and medical applications of pyrroles, such as in the biosynthesis of uroporphyrinogen III 1.20, their use as inte

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20

Lone, Anna Mari. "The Biochemistry and Physiology of Peptidases." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10693.

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Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which is a peptidase involved in several human deletion syndromes, including hypotonia-cystinuria syndrome (HCS). Phenotypes tentatively attributed to PREPL deletion include hypotonia and decreased growth hormone (GH) levels. However, little is known about the mechanisms by which PREPL deletion causes these phenotypes. To better understand PREPL catalytic activity, we used an activit

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21

Jordan, Peter A. "Physico-chemical studies of aluminium biochemistry." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294654.

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22

Bailey, A. C. "Biochemistry and pharmacology of beta-bungarotoxin." Thesis, University of Essex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372585.

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23

Foster, S. J. "Biochemistry of Bacillus megaterium spore germination." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384466.

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24

Duvold, Tore. "Chemistry and biochemistry of bacterial isoprenoids." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13195.

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Il etait unanimement accepte que la biosynthese des isoprenoides passait par le mevalonate. Des etudes recentes ont revele l'existence d'une voie alternative independante du mevalonate passante par le glyceraldehyde 3-phosphate (gap) et la pyruvate via une condensation et un rearrangement. Nous avons etudie le role du 2-c-methyleerythritol comme precurseur dans cette voie. En effet, des incorporations de glucose marque au #1#3c ont montre que chez corynebacterium ammoniagenes les squelettes du methylerythritol et des unites isopreniques etait formes de la meme facon. L'incorporation de #2h-2-c

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25

Pearce, Nicholas David. "An investigation of biochemistry higher education as a process of socialisation into the culture of the biochemistry community." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396269.

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26

Engström, Gunnar. "Temperamental diagnostics and biochemistry in suicide attempters." Lund : Dept. of Clinical Neuroscience, Division of Psychiatry, University Hospital, 1997. http://books.google.com/books?id=y9lrAAAAMAAJ.

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27

Messier, Marc D. "The chemistry and biochemistry of aromatase inhibitors." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6735.

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Aromatase is the last enzyme in estrogenesis, and as such is of central importance in estrogen metabolic and reproductive processes. Four central postulates of aromatase active site topology were elaborated: 1. The C-19 cavity postulate predicted that a cavity exists in aromatase. Steroids synthesized to investigate this postulate have confirmed that a 6A deep pocket exists to accommodate C-19 androgen derivatives. 2. The C-3 chelation postulate suggested that chelating groups at the C-3 position might constitute a new generation of aromatase inhibitors and cause aromatase inactivation. Steroi

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28

Abebe, Adal T. "Biochemistry of 1,2-dehydro-n-acetyldopamine derivatives." Thesis, University of Massachusetts Boston, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3564657.

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<p> Dehydrodopa/dopamine derivatives form an important group of biomolecules participating in sclerotization of all arthropod cuticles, gluing and cementing mussels and related organisms to solid surfaces, and defense reactions of countless marine and invertebrate organisms. Yet very little information is available on the biochemistry of these highly reactive and unstable molecules. To understand their physiological role, I conducted a thorough biochemical study on three representative compounds that cover the entire plethora of dehydrodopa/dopamine derivatives. Employing diode array UV-visibl

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29

Partington, Joanna Clair. "Biochemistry and molecular biology of potato bruising." Thesis, Royal Holloway, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265182.

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30

Baverstock, Jenny. "Biochemistry of visual transduction in squid photoreceptors." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302983.

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31

Langmack, Keith Antony. "Structure and biochemistry of squid photoreceptor microvilli." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253282.

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32

Channell, Guy Andrew. "Oxidative flavour chemistry and biochemistry in parsley." Thesis, University of Nottingham, 1996. http://eprints.nottingham.ac.uk/13970/.

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Deterioration of flavour quality during processing and storage is often brought about by oxidative processes. These typically involve oxygen or an active form of oxygen in effecting transformation of a wide range of volatile and non-volatile compounds, including key quality chemicals, flavour precursors and antioxidants. To investigate the nature of the chemical and biochemical change within vegetables and herbs, unblanched frozen parsley was selected as a suitable tissue. The chemical status of parsley during technological processing was determined using novel analytical protocols (SNCV A/SNC

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33

Bhatia, Jeetendra. "Biochemistry of visual transduction in cuttlefish receptors." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271670.

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34

Brown, Andrew M. G. "Biochemistry, tissue culture and pharmacology of Tanacetum." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363563.

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35

Buckberry, Lorraine Dawn. "The biochemistry of mammalian C-S lyases." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276184.

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36

Shams, Saleema Bashir. "Some new micro analytical techniques in biochemistry." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245056.

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37

Law, Samantha P. "The microbial biochemistry of slow sand filters." Thesis, Robert Gordon University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270109.

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38

Partridge, Robert James. "The biochemistry of the bovine preimplantation embryo." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245866.

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39

Taylor, Stephen Murray. "Rheology and biochemistry of whey protein gels." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308255.

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40

Rastall, Robert A. "The cell surface biochemistry of Erwinia amylovora." Thesis, University of Greenwich, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258366.

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41

McGeary, Sean E. (Sean Edward). "Understanding microRNA targeting with high-throughput biochemistry." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130661.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, February, 2021<br>Cataloged from the official PDF of thesis. Vita.<br>Includes bibliographical references.<br>MicroRNAs (miRNAs) are short RNAs that, in complex with Argonaute (AGO) proteins, guide repression of mRNA targets. miRNAs negatively regulate most mammalian mRNAs, and disruption of this regulation often results in severe defects at the cellular and organismal level. miRNA repression occurs primarily through base-pairing between the miRNA seed region (nucleotides 2-8) and mRNA 3'-UTR sites, leading to transi

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42

Darkwa, Alfred Anthony. "Growth and biochemistry of hardy European orchids." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495011.

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43

Oikonomou, Eftychia. "Molecular biology and biochemistry of brain tumours." Thesis, Aston University, 2004. http://publications.aston.ac.uk/11021/.

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Elucidating some molecular mechanisms and biochemistry of brain tumours is an important step towards the development of adjuvant medical therapies. The present study concentrates on cholecystokinin (CCK), a gut-brain peptide that has been described to be able to induce mitosis of rat gliomas as well as hormone secretion by the anterior pituitary, via the CCK-B receptor. The significance of a polymorphism in the growth hormone releasing hormone (GHRH) receptor (GHRH-R) gene was also determined. Finally, defects in the b-catenin gene, an important component of the developmental pathway, in a sub

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44

Churchill, Thomas Allen Carleton University Dissertation Biology. "Metabolic biochemistry of freeze tolerance in vertebrates." Ottawa, 1992.

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45

Bunn, Tristan. "Prion protein biochemistry in Creutzfeldt-Jakob disease." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23281.

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46

Jones, Colleen P. "Biochemistry of Selenium in Pariette Wetlands, Utah." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/3303.

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The Pariette Wetlands was constructed to provide wildlife habitat in an arid environment. Elevated levels of selenium (Se) have been detected in water, soil, and biota. Selenium concentrations have ranged from below detection limit to four times the water quality criterium limit. Here we report on three interrelated research topics: 1) selenium mass balance and flux in water, 2) selenium accumulation, concentration and volatilization of water and plant tissues; and 3) selenium sorption by upland and wetlands soils. 1) Mass balance and mass water flux of selenium for the Pariette Wetlands were

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47

Carlsson, Jens. "Challenges in Computational Biochemistry: Solvation and Ligand Binding." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8738.

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<p>Accurate calculations of free energies for molecular association and solvation are important for the understanding of biochemical processes, and are useful in many pharmaceutical applications. In this thesis, molecular dynamics (MD) simulations are used to calculate thermodynamic properties for solvation and ligand binding.</p><p>The thermodynamic integration technique is used to calculate p<i>K</i><sub>a</sub> values for three aspartic acid residues in two different proteins. MD simulations are carried out in explicit and Generalized-Born continuum solvent. The calculated p<i>K</i><sub>a</

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48

Thong, Kam-Wah. "Biochemistry of sulphur-containing amino acids in trichomonads." Thesis, University of Glasgow, 1986. http://theses.gla.ac.uk/1635/.

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49

Miller, S. Shea. "Oat beta-glucan: Biochemistry, structure and genetic variation." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7507.

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An enzymatic assay designed for measurement of $\beta$-glucan in barley was modified to allow measurement of total $\beta$-glucan content in oats by manipulating the grinding and incubation protocol. Using the modified enzymatic assay, the range of genetic and environmental variation of $\beta$-glucan content in Canadian domestic and breeder's lines of oats was assessed using several cultivars grown in 5 locations in eastern Canada in 3 growing seasons. Analysis of variance indicated that the predominant source of variation was genetic. A second assay using Flow Injection Analysis (FIA) to mea

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50

Kelly, Ronan. "Biophysics and biochemistry of the pancreatic β-cell". Thesis, University of Oxford, 1989. https://ora.ox.ac.uk/objects/uuid:e815cdec-ad16-4271-84e8-4ec8aaac842e.

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The β-cells of the pancreatic islets of Langerhans are the endocrine cells which secrete the hypoglycaemic hormone insulin. The primary stimulus for insulin secretion is an increase in the plasma glucose concentration, although secretion can be modulated by a variety of hormones and neurotransmitters. The immediate signal for insulin release is calcium entry through the β-cell plasma membrane. Primary secretagogues are glucose and those other secretagogues capable of initiating insulin secretion (e.g. glyceraldehyde, leucine, 2- ketoisokaproate); secondary secretagogues are those whi

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