Academic literature on the topic 'Biodentine™'
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Journal articles on the topic "Biodentine™"
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Abuarqoub, Duaa, Nazneen Aslam, Hanan Jafar, Zakariya Abu Harfil, and Abdalla Awidi. "Biocompatibility of Biodentine™ ® with Periodontal Ligament Stem Cells: In Vitro Study." Dentistry Journal 8, no. 1 (February 8, 2020): 17. http://dx.doi.org/10.3390/dj8010017.
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Biodentine™ is a tricalcium silicate-based cement material that has a great impact on different biological processes of dental stem cells, compared to other biomaterials. Therefore, we aimed to investigate the optimum biocompatible concentration of Biodentine™ with stem cells derived from periodontal ligament (hPDLSCs) by determining cell proliferation, cytotoxicity, migration, adhesion and mineralization potential. hPDLSCs were treated with Biodentine™ extract at different concentrations; 20, 2, 0.2 and 0.02 mg/mL. Cells cultured without Biodentine™ were used as a blank control. The proliferation potential of hPDLSCs was evaluated by MTT viability analysis for 6 days. Cytotoxicity assay was performed after 3 days by using AnnexinV/7AAD. Migration potential was investigated by wound healing and transwell migration assays at both cellular and molecular levels. The expression levels of chemokines CXCR4, MCP-1 and adhesion molecules FGF-2, FN, VCAM and ICAM-1 were measured by qPCR. The communication potentials of these cells were determined by adhesion assay. In addition, mineralization potential was evaluated by measuring the expression levels of osteogenic markers; ALP, OCN, OPN and Collagen type1 by qPCR. Our results showed significant increase in the proliferation of hPDLSCs at low concentrations of Biodentine™ (2, 0.2 and 0.02 mg/mL) while higher concentration (20 mg/mL) exhibited cytotoxic effect on the cells. Moreover, 2 mg/mL Biodentine™ showed a significant increase in the migration, adhesion and mineralization potentials of the derived cells among all concentrations and when compared to the blank control. Our findings suggest that 2 mg/mL of Biodentine™ is the most biocompatible concentration with hPDLSCs, showing a high stimulatory effect on the biological processes.
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Aljdaimi, Abtesam, Hugh Devlin, and Mark Dickinson. "Effect of the Er: YAG laser on the shear bond strength of conventional glass ionomer and BiodentineTM to dentine." European Journal of Dentistry 12, no. 03 (July 2018): 380–85. http://dx.doi.org/10.4103/ejd.ejd_410_17.
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ABSTRACTObjectives: The purpose of this study was to determine if Er: YAG laser etching improves the shear bond strength (SBS) of Biodentin™ and GC Fuji IX® to dentine. Materials and Methods: Forty human dentine specimens were standardized and embedded in stone. The specimens were randomized into four groups (n = 10). Twenty samples were treated with the Er: YAG laser radiation and 10 of these restored with GC Fuji IX® and 10 with Biodentine™. The remaining 20 specimens acted as controls (no laser treatment); 10 were restored with GC Fuji IX® and 10 with Biodentin™. All samples were then stored in an incubator at 37.5°C and 100% humidity for 7 days. The SBS was determined using a Zwick universal testing machine. A two-way analysis of variance test was used to evaluate the statistical difference in SBS between the groups. An independent sample t-test was used to determine the statistical significance of differences between control and lased groups within the same material. Results: A highly statistically significant difference in SBS was found with the laser treatment (P = 0.0001) and material (i.e., Biodentin™ or Fuji IX® (P = 0.0001). The GC Fuji IX® group recorded the highest mean SBS required to dislodge the material from the laser-treated dentine surface (1.77 ± 0.22 Mega-Pascal [MPa]). The mean SBS of Biodentin™ to dentine following the laser radiation (1.12 ± 0.16 MPa) was significantly greater compared to the nonlased dentine (0.53 ± 0.09). Pearson Chi-square test indicated a nonsignificant relation between shear strength and mode of failure (P = 0.467). Conclusion: Laser etching of the dentine surfaces yielded a significant increase in the bond strength for both GC Fuji IX® and Biodentin™. The SBS of Biodentin™ to dentine is greater than with conventional glass ionomer (Fuji IX®).
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Paula, Anabela, Mafalda Laranjo, Carlos Miguel Marto, Ana Margarida Abrantes, João Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Manuel M. Ferreira, Maria Filomena Botelho, and Eunice Carrilho. "Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast Activity." Materials 12, no. 7 (April 11, 2019): 1184. http://dx.doi.org/10.3390/ma12071184.
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(1) Background: When pulp exposure occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain the vitality and function of the tissue. The aim of this work was to assess the cytotoxicity and bioactivity of three different direct pulp capping materials, calcium hydroxide (Life®), mineral trioxide aggregate (WhiteProRoot®MTA) and calcium silicate (Biodentine™), in an odontoblast-like mouse cell line (MDPC-23). (2) Methods: Metabolic activity was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (MTT)assay, viability by the sulforhodamine B (SRB) assay, and the type of death and cell cycle analysis by flow cytometry. Alkaline phosphatase was evaluated by polymerase chain reaction (PCR), and dentin sialoprotein expression was assessed by immunocytochemistry. Mineralization was determined by the Alizarin Red S colorimetric assay and quantified by spectrophotometry. (3) Results: Life® induced a decrease in metabolic activity and viability, which is associated with an increase cell death. WhiteProRoot®MTA and Biodentine™ induced similar effects in cytotoxicity assays, with an increase in the expression of dentin sialoprotein (DSP) and formation of mineralized deposits, especially with Biodentine™. (4) Conclusions: The results of WhiteProRoot®MTA confirm its indication for these therapies, justifying its recognition as the “gold standard”. Biodentine™ may be an alternative, since they promote the same cellular response that mineral trioxide aggregate (MTA) does.
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Poplai, Gaurav, and Sameer Jadhav. "Effect of Acidic Environment on the Push-out Bond Strength of Biodentine™." World Journal of Dentistry 3, no. 4 (2012): 313–15. http://dx.doi.org/10.5005/jp-journals-10015-1180.
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ABSTRACT Introduction An apical sealing material may be exposed to an inflamed environment with low pH levels. The change in physical and chemical properties of mineral trioxide aggregate has been well-documented in the presence of low pH. However, on literature search there is no documentation of the effect of low pH on Biodentine™. Aim To compare the effects of various levels of acidic pH on the push-out bond strength of Biodentine™. Materials and methods Forty root dentin slices from single rooted human teeth were sectioned horizontally. The canal lumens were instrumented to obtain a standardized diameter of 1.3 mm and filled with Biodentine™. The specimens were then randomly divided into four groups (n = 10) and wrapped in pieces of gauze soaked in phosphate buffer saline solution (pH = 7.4) and butyric acid buffered at pH values of 4.4, 5.4 and 6.4 respectively. They were incubated at 37°C for 4 days. Push-out test were then carried out using universal testing machine. The data was analyzed using one-way analysis of variance (ANOVA) technique with Tukey's correction for multiple group comparisons. Results Data was subjected to one-way ANOVA using Tukey's post hoc test. Group I (control, pH = 7.4) showed greatest bond strength of 19.5 ± 0.9 MPa. The least push-out bond strength of 11.7 ± 0.5 MPa was observed in Group IV where the specimens were soaked at pH 4.4. A p-value less than 0.05 were considered to be statistically significant. Conclusion The force needed to displace Biodentine was significantly lower in samples stored at lower pH values. How to cite this article Poplai G, Jadhav S, Hegde V. Effect of Acidic Environment on the Push-out Bond Strength of Biodentine™. World J Dent 2012;3(4):313-315.
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Suárez-Franco, J. L., B. I. Cerda-Cristerna, A. Suárez-Porras, R. E. Flores-Ventura, M. Trujillo-Hernández, and R. Trueba-García. "Physicochemical study of Biodentine™-dentine tissue interphase." Dental Materials 35 (2019): e39. http://dx.doi.org/10.1016/j.dental.2019.08.079.
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Paula, Anabela, Eunice Carrilho, Mafalda Laranjo, Ana M. Abrantes, João Casalta-Lopes, Maria Filomena Botelho, Carlos Miguel Marto, and Manuel M. Ferreira. "Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective Clinical Study." Materials 12, no. 20 (October 16, 2019): 3382. http://dx.doi.org/10.3390/ma12203382.
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(1) Background: Recently, tricalcium silicate cements, such as Biodentine™, have emerged. This biomaterial has a calcium hydroxide base and characteristics like mineral aggregate trioxide cements, but has tightening times that are substantially more suitable for their application and other clinical advantages. (2) Methods: A retrospective clinical study was conducted with 20 patients, which included a clinical evaluation of the presence or absence of pulp inflammation compatible symptoms, radiographic evaluation of the periapical tissues, and structural alterations of the coronary restoration that supports pulp capping therapies with Biodentine™ and WhiteProRoot®MTA. (3) Results: This clinical study revealed similar success rates between mineral trioxide cement and tricalcium silicates cements at 6 months, with 100% and 95% success rates, respectively. There were no statistically significant differences between both biomaterials and between these and the various clinical circumstances, namely the absolute isolation of the operating field, exposure size, the aetiology of exposure, and even the type of restorative material used. (4) Conclusions: Biodentine™ demonstrated a therapeutic effect on the formation of a dentin bridge accompanied by slight inflammatory signs, with a high clinical success rate, indicating the possibility of its effective and safe use in dental pulp direct capping in humans, similar to the gold standard material.
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Chinadet, W., T. Sutharaphan, and P. Chompu-inwai. "Biodentine™ Partial Pulpotomy of a Young Permanent Molar with Signs and Symptoms Indicative of Irreversible Pulpitis and Periapical Lesion: A Case Report of a Five-Year Follow-Up." Case Reports in Dentistry 2019 (September 12, 2019): 1–5. http://dx.doi.org/10.1155/2019/8153250.
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The purpose of this paper was to report the five-year success of Biodentine™ partial pulpotomy in a young permanent molar, with signs and symptoms indicative of irreversible pulpitis and periapical lesion, in a nine-year-old girl. Preoperative clinical examination revealed a large carious lesion of the left mandibular permanent first molar. The patient reported pain on percussion. The tooth responded positively to the electric pulp test and had lingering pain after cold testing. A periapical radiograph showed a deep carious lesion and periapical lesion. Based on the clinical and radiographical examination, the tooth had signs and symptoms indicative of irreversible pulpitis and periapical lesion. During caries removal, pulp exposure occurred, and 2-3 mm in depth of pulp tissue at the exposure site was removed. Haemorrhage was controlled within four minutes with 2.5% sodium hypochlorite-moistened cotton pellets. Biodentine™ was then applied as both a pulp dressing and a temporary restoration. At the following visit, composite resin was placed over the Biodentine™ as a final restoration. During a five-year follow-up, the tooth was asymptomatic, had positive responses to sensibility tests, and had no discolouration. Follow-up radiographs showed a dentine bridge and periapical healing.
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Brenes-Valverde DDS, Karen, Elian Conejo-Rodríguez PhD, José Roberto Vega-Baudrit PhD, Mauricio Montero-Aguilar MSc, and Daniel Chavarría-Bolaños MSc, PhD. "Evaluation of Microleakage by Gas Permeability and Marginal Adaptation of MTA and Biodentine™ Apical Plugs: In Vitro Study." Odovtos - International Journal of Dental Sciences 20, no. 1 (November 16, 2017): 57–67. http://dx.doi.org/10.15517/ijds.v0i0.28952.
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The endodontic treatment of teeth with incomplete development is always a complex task. Nowadays, biomaterials such as bioceramics offers promising clinical evidence that supports its use. However, the standardization of its use for apexification purpose still needs a deeper understanding of the materials’ behavior. The aim of this investigation was to evaluate the marginal adaptability and microleakage by gas permeability of MTA and Biodentine™ apical plugs in an in vitro model. Materials and methods: Twenty-four single rooted human teeth were selected according to previously stablished inclusion criteria. All samples were prepared obtaining standard cylindrical internal canals with a diameter of 1.3 mm. Root canals were gently rinsed using 5.25% sodium hypochlorite and EDTA 17%. The apical 3mm and remaining coronal dental structure were sectioned to obtain 10mm roots. Roots were randomly assigned to 3 different groups as follows: GROUP A: MTA (n=10), GROUP B: Biodentine™ (n=10) and Group C: Control (positive n=1, negative n=3). MTA and Biodentine™ were prepared according to manufacturer’s indications, and apical plugs of 4mm were passively placed in the correspondent teeth. All samples were stored in saline solution for 7 days at 37°C before evaluation. Samples were mounted in cylindrical sample-holders using epoxy resin. Microleakage was evaluated with an automatic permeability detector that calculates nitrogen diffusion between the material-root interphase. After microleakage evaluation, the samples were recovered and analyzed by scanning electron microscopy (SEM). Microleakage results were analyzed using Chi-square and adaptation was evaluated with a descriptive analysis. Results: None of the evaluated materials completely avoided the nitrogen microleakage (positive leakage of 10% and 20% of samples for MTA and Biodentine™ respectively); with no statistical significant difference between groups (p=0.527). All apical plugs showed good adaptation under SEM, at 30x, 200x, 1000x and 2500x; with microscopical structures similar to previous reports. Conclusions: Both bioceramics behave similar when used as apical barriers to avoid permeability, with acceptable marginal adaptation. Further in vivo studies are needed to validate these results.
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Brenes-Valverde DDS, Karen, Elian Conejo-Rodríguez PhD, José Roberto Vega-Baudrit PhD, Mauricio Montero-Aguilar MSc, and Daniel Chavarría-Bolaños MSc, PhD. "Evaluation of Microleakage by Gas Permeability and Marginal Adaptation of MTA and Biodentine™ Apical Plugs: In Vitro Study." Odovtos - International Journal of Dental Sciences 20, no. 1 (November 16, 2017): 57–67. http://dx.doi.org/10.15517/ijds.v20i1.28952.
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The endodontic treatment of teeth with incomplete development is always a complex task. Nowadays, biomaterials such as bioceramics offers promising clinical evidence that supports its use. However, the standardization of its use for apexification purpose still needs a deeper understanding of the materials’ behavior. The aim of this investigation was to evaluate the marginal adaptability and microleakage by gas permeability of MTA and Biodentine™ apical plugs in an in vitro model. Materials and methods: Twenty-four single rooted human teeth were selected according to previously stablished inclusion criteria. All samples were prepared obtaining standard cylindrical internal canals with a diameter of 1.3 mm. Root canals were gently rinsed using 5.25% sodium hypochlorite and EDTA 17%. The apical 3mm and remaining coronal dental structure were sectioned to obtain 10mm roots. Roots were randomly assigned to 3 different groups as follows: GROUP A: MTA (n=10), GROUP B: Biodentine™ (n=10) and Group C: Control (positive n=1, negative n=3). MTA and Biodentine™ were prepared according to manufacturer’s indications, and apical plugs of 4mm were passively placed in the correspondent teeth. All samples were stored in saline solution for 7 days at 37°C before evaluation. Samples were mounted in cylindrical sample-holders using epoxy resin. Microleakage was evaluated with an automatic permeability detector that calculates nitrogen diffusion between the material-root interphase. After microleakage evaluation, the samples were recovered and analyzed by scanning electron microscopy (SEM). Microleakage results were analyzed using Chi-square and adaptation was evaluated with a descriptive analysis. Results: None of the evaluated materials completely avoided the nitrogen microleakage (positive leakage of 10% and 20% of samples for MTA and Biodentine™ respectively); with no statistical significant difference between groups (p=0.527). All apical plugs showed good adaptation under SEM, at 30x, 200x, 1000x and 2500x; with microscopical structures similar to previous reports. Conclusions: Both bioceramics behave similar when used as apical barriers to avoid permeability, with acceptable marginal adaptation. Further in vivo studies are needed to validate these results.
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Alotaibi, J., S. Saji, and M. V. Swain. "FTIR characterization of the setting reaction of biodentine™." Dental Materials 34, no. 11 (November 2018): 1645–51. http://dx.doi.org/10.1016/j.dental.2018.08.294.
Full textDissertations / Theses on the topic "Biodentine™"
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Fonseca, Tiago Silva da. "Resposta tecidual induzida por Biodentine™e MTA Branco em subcutâneo de ratos /." Araraquara, 2014. http://hdl.handle.net/11449/115646.
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Orientador: Paulo Sergio CerriCo-orientador: Juliane Maria Guerreiro Tanomaru
Banca: Manuel de Jesus Simões
Banca: Mario Tanomaru Filho
Resumo: BiodentineTM é um biomaterial à base de silicato de cálcio produzido, segundo o fabricante, com o intuito de apresentar propriedades físico-químicas e biológicas superiores ao MTA. Nosso objetivo foi avaliar a resposta tecidual promovida por BiodentineTM (BDT) e MTA Angelus Branco em subcutâneo de ratos. Foram utilizados ratos adultos distribuídos em 3 grupos (n=20/grupo), segundo o material preenchendo os tubos de polietileno implantados no subcutâneo: BDT, MTA e GC (controle, tubos vazios). Após 7, 15, 30 e 60 dias, os implantes e os tecidos adjacentes foram processados para parafina. Cortes longitudinais das cápsulas adjacentes aos implantes foram corados com H&E, tricrômico de Masson, Picrosirius e submetidos ao Alcian Blue (AB) e reações imuno-histoquímicas para IL-6 e FGF-1. Obteve-se a densidade numérica de células inflamatórias (CI), de células imunomarcadas para IL-6 e FGF-1 e de mastócitos AB-positivos, além da porcentagem de colágeno birrefringente. Os dados foram submetidos à ANOVA e teste Tukey (p≤0,05). O número de CI e de células imunomarcadas para IL-6 e FGF-1 foi significantemente maior aos 7 dias em todos os grupos. Diferenças significantes no número de células IL-6-positivas não foram observadas entre BDT e MTA aos 30 e 60 dias; aos 60 dias, diferenças significantes no número de CI também não foram detectadas. O número de células FGF-1-positivas foi significantemente maior no grupo BDT em comparação ao grupo MTA, em todos os períodos. A densidade numérica de mastócitos e a porcentagem de colágeno aumentaram significantemente ao longo do tempo. Aos 60 dias, o número de mastócitos e o conteúdo de colágeno foram significantemente maiores nos grupos BDT e MTA, respectivamente. A redução significante do processo inflamatório, concomitante à redução na imunoexpressão para IL-6, indica que ambos os materiais são biocompatíveis. A acentuada imunoexpressão de FGF-1 aos 7 dias...
Abstract: BiodentineTM is a new calcium silicate-based biomaterial which presents improved physicochemical and biological properties compared to MTA. The aim of this study was to evaluate the tissue reaction promoted by BiodentineTM (BDT) and MTA Angelus White in rat subcutaneous. Adult rats were distributed into 3 groups (n=20/group) according to the implanted materials: BDT, MTA or CG (Control group; empty tubes). After 7, 15, 30 and 60 days, the implants and adjacent tissues were fixed and embedded in paraffin. Longitudinal sections of the capsule adjacent to implants were stained with H&E, Masson's trichrome, Picrosirius and submitted to Alcian Blue (AB). Immunohistochemical reactions for IL-6 and FGF-1 were also performed. The number of inflammatory cells (IC), IL-6 and FGF-1 immunolabeled cells, AB-positive mast cells as well as birefringent collagen percentage were obtained. Data were statistically analyzed by ANOVA and Tukey test (p≤0.05). The number of IC and IL-6 and FGF-1 immunolabeled cells were significantly high at 7 days in all groups. At 30 and 60 days, significant differences in the number of IL-6-positive cells were not detected between BDT and MTA. At 60 days, statistical difference in the IC number was not observed between BDT and MTA groups. In all periods, the number of FGF-1-positive cells was significant higher in BDT group in comparison to MTA. The numerical density of mast cells and collagen percentage increased over time. At 60 days, mast cells number and collagen content were significantly high in BDT and MTA groups, respectively. A significant reduction of inflammatory process and IL-6 immunoexpression indicates that both materials are biocompatible. Intense FGF-1 immunoexpression at 7 days suggests that this factor may be responsible, at least in part, for fibroblast proliferation and subsequent collagen formation in the capsules. Since a strong correlation between mast cells number and collagen density was detected...
Mestre
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Fonseca, Tiago Silva da [UNESP]. "Resposta tecidual induzida por Biodentine™e MTA Branco em subcutâneo de ratos." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/115646.
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000806813.pdf: 3961779 bytes, checksum: 134f6d96d64debccca8243b79f70742a (MD5)BiodentineTM é um biomaterial à base de silicato de cálcio produzido, segundo o fabricante, com o intuito de apresentar propriedades físico-químicas e biológicas superiores ao MTA. Nosso objetivo foi avaliar a resposta tecidual promovida por BiodentineTM (BDT) e MTA Angelus Branco em subcutâneo de ratos. Foram utilizados ratos adultos distribuídos em 3 grupos (n=20/grupo), segundo o material preenchendo os tubos de polietileno implantados no subcutâneo: BDT, MTA e GC (controle, tubos vazios). Após 7, 15, 30 e 60 dias, os implantes e os tecidos adjacentes foram processados para parafina. Cortes longitudinais das cápsulas adjacentes aos implantes foram corados com H&E, tricrômico de Masson, Picrosirius e submetidos ao Alcian Blue (AB) e reações imuno-histoquímicas para IL-6 e FGF-1. Obteve-se a densidade numérica de células inflamatórias (CI), de células imunomarcadas para IL-6 e FGF-1 e de mastócitos AB-positivos, além da porcentagem de colágeno birrefringente. Os dados foram submetidos à ANOVA e teste Tukey (p?0,05). O número de CI e de células imunomarcadas para IL-6 e FGF-1 foi significantemente maior aos 7 dias em todos os grupos. Diferenças significantes no número de células IL-6-positivas não foram observadas entre BDT e MTA aos 30 e 60 dias; aos 60 dias, diferenças significantes no número de CI também não foram detectadas. O número de células FGF-1-positivas foi significantemente maior no grupo BDT em comparação ao grupo MTA, em todos os períodos. A densidade numérica de mastócitos e a porcentagem de colágeno aumentaram significantemente ao longo do tempo. Aos 60 dias, o número de mastócitos e o conteúdo de colágeno foram significantemente maiores nos grupos BDT e MTA, respectivamente. A redução significante do processo inflamatório, concomitante à redução na imunoexpressão para IL-6, indica que ambos os materiais são biocompatíveis. A acentuada imunoexpressão de FGF-1 aos 7 dias...
BiodentineTM is a new calcium silicate-based biomaterial which presents improved physicochemical and biological properties compared to MTA. The aim of this study was to evaluate the tissue reaction promoted by BiodentineTM (BDT) and MTA Angelus White in rat subcutaneous. Adult rats were distributed into 3 groups (n=20/group) according to the implanted materials: BDT, MTA or CG (Control group; empty tubes). After 7, 15, 30 and 60 days, the implants and adjacent tissues were fixed and embedded in paraffin. Longitudinal sections of the capsule adjacent to implants were stained with H&E, Masson’s trichrome, Picrosirius and submitted to Alcian Blue (AB). Immunohistochemical reactions for IL-6 and FGF-1 were also performed. The number of inflammatory cells (IC), IL-6 and FGF-1 immunolabeled cells, AB-positive mast cells as well as birefringent collagen percentage were obtained. Data were statistically analyzed by ANOVA and Tukey test (p?0.05). The number of IC and IL-6 and FGF-1 immunolabeled cells were significantly high at 7 days in all groups. At 30 and 60 days, significant differences in the number of IL-6-positive cells were not detected between BDT and MTA. At 60 days, statistical difference in the IC number was not observed between BDT and MTA groups. In all periods, the number of FGF-1-positive cells was significant higher in BDT group in comparison to MTA. The numerical density of mast cells and collagen percentage increased over time. At 60 days, mast cells number and collagen content were significantly high in BDT and MTA groups, respectively. A significant reduction of inflammatory process and IL-6 immunoexpression indicates that both materials are biocompatible. Intense FGF-1 immunoexpression at 7 days suggests that this factor may be responsible, at least in part, for fibroblast proliferation and subsequent collagen formation in the capsules. Since a strong correlation between mast cells number and collagen density was detected...
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Ramos, Eduardo Coimbra de Oliveira. "Utilização de cimentos biocerâmicos em endodontia: biodentine™." Master's thesis, 2017. http://hdl.handle.net/10284/6559.
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Introdução e objectivos:
Com o presente trabalho, propomos-nos a analisar o que a literatura científica actual, tem vindo a relatar, relativamente aos cimentos Biocerâmicos à base de silicato de cálcio, mais específicamente o material denominado por Biodentine™. Propomo-nos a tentar esclarecer se as características anunciadas como promissoras pelo fabricante nas diversas aplicações deste cimento se confirmam na realidade, através da pesquisa e análise bibliográfica de estudos já realizados.
Materiais e Métodos:
Para a realização da pesquisa bibliográfica foram usados os motores de busca e bases de dados da “Pub med”, “scielo” e “Google académico”. Foram selecionados artigos de revisão bibliográfica, meta-análise e estudos randomizados, disponíveis em língua inglesa, que no âmbito da pesquisa de seleção estivessem limitados temporalmente desde o ano 2000 a 2017, tendo sido este o critério de inclusão principal.
Discussão:
Foram referênciadas as diversas utilizações indicadas do Biodentine™, que, como cimento da família dos cimentos à base de silicato de cálcio, apresenta vantagens relativamente a cimentos tradicionais como Hidróxido de Cálcio, Ionómero de Vidro, Óxido de Zinco-Eugenol e, mesmo relativamente ao actual MTA.
Conclusão:
Concluiu-se que o Biodentine™ apresenta bom comportamento nas utilizações que lhe são indicadas, respondendo de forma expectável às solicitações de que é alvo. Notou-se no entanto, que devem ser feitos mais estudos sobre a utilização do mesmo, nomeadamente nos casos em que foi notada que a sua dificuldade de remoção pode prejudicar o retratamento endodôntico.Introduction and objectives: This bibliographical revision purposes to refer what the actual scientific literature has been mentioning about the Bioceramic, calcium-silicate based cements, specifically Biodentine™. It aims to confirm if its promising characteristics referred by the manufacturer on the diverse mentioned applications, based on bibliographic research of scientific, studies are indeed real. Material and methods: To perform the bibliographic research there were used the “Pub med”, “scielo” and “Google académico” databases and search engines. The articles selected were bibliographic revision, meta-analysis or randomized studies kind, published in English language between 2000 and 2017, being this, the main inclusion criteria. Discussion: Diverse Biodentine™ indications were referred and it was noticed that being a calcium silicate based cement, it has diverse advantages relatively to other cements like calcium hydroxide, glass ionomer, zinc oxide eugenol, and even to the actual MTA. Conclusion: It was possible to conclude that Biodentine™ has a good behavior on its indicated uses, and its response to solicitations of usage is very satisfactory. It was, nevertheless, noted a need for more future studies to be performed on its usage behavior, namely on the cases that the removal of Biodentine™ was noted as being somewhat difficult when an endodontic retreatment is needed.
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Batista, Melissa Cordeiro Malta Anes. "Resistências adesivas de diferentes sistemas adesivos ao MTA e Biodentine™." Master's thesis, 2014. http://hdl.handle.net/10400.26/13767.
Full textAbstract:
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizObjetivos: Comparar as resistências adesivas de diferentes sistemas adesivos ao ProRoot® MAT e BIODENTINE™ em três intervalos de tempo. Materiais e métodos: Foram preparados 180 blocos de acrílico, os quais foram preenchidos com ProRoot® MTA (n=90) ou BIODENTINE™ (n=90) e divididos em 18 grupos (n=10), consoante a estratégia adesiva (Scotchbond™ Universal - versão etch & rinse (SUER), Scotchbond™ Universal - versão self-etch (SUSE) e Adper™ Scotchbond™ 1 XT (SB)), e os tempos de envelhecimento, (7 dias (7d), 72 horas (72H) e 4 horas/12 minutos (4H/12Min)), num ambiente a 37ºC e 100% de humidade. A todos os espécimes foi aplicada resina composta (Grandio® SO). Após 24H, em estufa, foram realizados testes de resistência adesiva ao corte e avaliou-se o tipo de falha de união. Os valores das resistências adesivas e os tipos de falha de união foram analisados com os testes de Mann-Whitney e de Kruskal-Wallis, tendo-se definido um nível de significância de 5%. Resultados: Relativamente ao substrato, observaram-se diferenças estatisticamente significativas entre os valores médios de resistência adesiva obtidos para cada estratégia adesiva: ProRoot® MTA [variação entre 7,02MPa (SUSE) e 3,22MPa (SB), (p=0,014)]; BIODENTINE™ [variação entre 7,07MPa (SUER) e 3,23MPa (SBS), (p=0,002)]. Considerando os tempos de envelhecimento, no caso do ProRoot® MTA as resistências adesivas variaram entre 7,64MPa (72H) e 3,14MPa (7d) com diferenças estatisticamente significativas (p=0,007). Os resultados diferiram relativamente ao BIODENTINE™ com variações entre 6,10MPa (7d) e 3,37MPa (12 Min) sem diferenças estatisticamente significativas (p=0,181). Conclusões: Diferentes estratégias adesivas resultaram em diferentes resistências adesivas nos dois substratos estudados. Não foram encontradas diferenças significativas nas resistências adesivas destes adesivos no três intervalos de tempo.
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Carvalho, Joana Araújo. "Análise espectrofotométrica in vitro da descoloração coronária induzida por vários cimentos biocerâmicos." Master's thesis, 2017. http://hdl.handle.net/10400.26/19965.
Full textAbstract:
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizObjetivo: Avaliar e quantificar in-vitro a descoloração coronária induzida por materiais biocerâmicos e a sua influência na determinante “tempo”. Materiais e Métodos: Prepararam-se 44 dentes monoradiculares humanos, divididos em quatro grupos (n=11): G1 - controlo negativo; G2 - preenchimento com White MTA ProRoot® (Dentsply, York, USA), G3 - preenchimento com Biodentine™ (Septodont, Saint-Maur-des-Fossés, França) e o G4 - preenchimento com TotalFill® BC RRM™ Fast Set Putty (FKG, Crêt-du-Locle 4, CH-2304, La Chaux-de-Fonds, Switzerland). Posteriormente à colocação destes cimentos biocerâmicos, os dentes foram imersos em soro fisiológico e sujeitos a vários períodos de incubação a 37º C (t24h: 24h, t7d: 7 dias e t30d: 30 dias; t0 e t1 corresponderam aos momentos antes da incubação, antes e após aplicação imediata do material respectivamente). Efetuou-se a análise estatística descritiva e inferencial. O teste Q Cochran testou a descoloração coronária nos diferentes grupos, o teste Kruskal Wallis verificou diferenças na descoloração nos quatro grupos experimentais e por fim o teste de Friedman testou a variação de descoloração nos diferentes grupos ao longo do tempo. Foi determinado um nível de significância de 5%. Resultados: Todos os grupos experimentais apresentaram descoloração coronária ao longo do tempo G1 - (p= 0,001), G2 - (p <0,001), G3 - (p=0,001) e G4 - (p= 0,006) não sendo significativa entre grupos (p> 0,05). No intervalo de tempo final [t7d-t30d] o grupo TotalFill foi o que apresentou maior descoloração (ΔE = 7,29), seguido do MTA (ΔE = 6,64), Controlo (ΔE = 6,40) e Biodentine (ΔE = 5,49). No entanto, esta descoloração não foi estatisticamente significativa (p= 0,779). Dos quatro grupos experimentais o que mais variou, apesar de no final todos os grupos apresentarem descoloração idêntica, foi o grupo MTA (p= 0,037) nos intervalos de tempo [t0-t1] e [t24h-t7d]. Conclusões: Todos os materiais induziram descoloração ao longo do tempo, mas sem diferenças significativas comparativamente com o grupo de controlo.
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Penques, Eduardo Soares. "Clinical evidence of vital pulp therapy in cariously exposed permanent mature teeth systematic review and meta-analysis." Master's thesis, 2021. http://hdl.handle.net/10400.26/38247.
Full textAbstract:
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizIntroduction: The treatment of teeth can be carried out using different vital pulp therapies (direct pulp capping, partial pulpotomy and total pulpotomy) which are reported in the literature as viable options given their high short-term success rate. Methodology: A bibliographic search was carried out between 01/01/2011 and 10/03/2021, in the databases of PubMed, B-on, Scopus and Web of Science, following the search protocol registered in PROSPERO under number CRD42021256409, having as based on the following research question: "What is the relative effectiveness of vital pulp therapy protocols used to treat teeth with pulp involvement?" risk of bias analysis was performed with the RoB2 tool. The meta-analysis initially synthesized only evidence from direct comparisons through the RevMan web platform, using models for randomized effects. A network meta-analysis was then performed, using Stata 17 software, to synthesize the available evidence, integrating direct and indirect estimates. Results: Sixteen studies were included in this review, after applying the inclusion criteria to the research results. After risk assessment of bias and data processing with metaanalysis tools, the data showed that the treatment of total pulpotomy with biodentin is probably the best treatment option in vital pulp therapy, followed by partial pulpotomy with MTA and direct pulp capping with MTA and total pulpotomy with MTA. Conclusion: Vital pulp treatments are an interesting treatment option that allows the maintenance of pulp vitality associated with good long-term results. The new biomaterials have proven to be superior to established treatments, with MTA presenting good results both in direct pulp capping and in partial and total pulpotomy, with biodentin presenting itself as the best result, but only in total pulpotomy.
Introdução: O tratamento de dentes pode ser efectuado recorrendo a diferentes terapias de polpa vital (proteção pulpar direta, pulpotomia parcial e pulpotomia total) as quais se encontram reportadas, na literatura, como opções viáveis dado apresentarem elevada taxa de sucesso a curto prazo. Metodologia: Foi realizada uma pesquisa bibliográfica entre 01/01/2011 e 03/10/2021, nas bases de dados do PubMed, B-on, Scopus e Web of Science, seguindo o protocolo de busca registrado na PROSPERO sob o nº CRD42021256409, tendo como base a seguinte questão de investigação: "Qual a eficácia relativa dos protocolos de terapia de polpa vital utilizados para tratar dentes com envolvimento pulpar?” foi realizada análise de risco de viés com a ferramenta RoB2. A meta-análise sintetizou inicialmente apenas a evidência proveniente de comparações diretas através da plataforma RevMan web, utilizando modelos para efeitos randomizados. Foi posteriormente realizada uma meta-análise em rede, usando o software Stata 17, para sintetizar a evidência disponível, integrando as estimativas directas e indirectas. Resultados: Foram incluídos dezasseis estudos na presente revisão, após aplicação dos critérios de inclusão aos resultados da pesquisa. Após avaliação de risco de enviesamento e processamento de dados com ferramentas de meta-análise, os dados mostraram que o tratamento de pulpotomia total com Biodentine™ é provavelmente a melhor opção de tratamento na terapia pulpar vital, seguido de pulpotomia parcial com MTA e capeamento pulpar direto com MTA e pulpotomia total com MTA. Conclusão: Os tratamentos da polpa vital são uma opção de tratamento interessante que permite a manutenção da vitalidade pulpar associada a bons resultados a longo prazo. Os novos biomateriais têm se mostrado superiores aos tratamentos já estabelecidos, com o MTA apresentando bons resultados tanto na proteção pulpar directa quanto na pulpotomia parcial e total, com o Biodentine™ apresentando-se como o melhor resultado, mas apenas na pulpotomia total.
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Brito, Beatriz Constantino Almada de. "Materiais de proteção pulpar direta. Qual a melhor opção terapêutica?" Master's thesis, 2021. http://hdl.handle.net/10400.26/38903.
Full textAbstract:
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizNa área de proteção pulpar a quantidade de materiais que surgem no mercado com indicação para este tipo de procedimento é cada vez maior. O hidróxido de cálcio considerado durante algumas décadas como o gold standard apresenta diversas desvantagens que poderão comprometer o sucesso do tratamento a médio/longo prazo. O MTA tem sido o material de eleição utilizado para a proteção da polpa dentária de modo a preservar a vitalidade pulpar. Apesar das grandes vantagens do MTA, este material apresenta algumas desvantagens, nomeadamente a nível de manipulação e custo, fazendo surgir novos materiais como o Biodentine™. O Biodentine™ é um material mais recente, com maior biocompatibilidade, menor custo e mais fácil utilização. As indicações para a aplicação do Biodentine™ são semelhantes às do MTA, no entanto mais estudos terão que ser feitos para uma utilização mais generalizada ou até ser considerado gold standard. Em relação aos materiais atualmente utilizados em proteção pulpar direta existentes no mercado, nomeadamente os mais recentemente introduzidos, são necessários mais estudos clínicos.
In the area of pulp protection, the quantity of possible materials to be used on the market is increasing. Calcium Hydroxide, considered as the first gold standard, has several disadvantages that could compromise the success of the work in the medium / long term. MTA has been the material of choice used to protect the dental pulp in order to preserve the pulp vitality. Despite the great advantages of MTA, it presents some disadvantages, namely in terms of handling and cost, giving rise to new materials such as Biodentine™. Biodentine™ is a newer material, with greater biocompatibility, lower cost and easier to use. The indications for the application of Biodentine™ are similar to those of MTA, however more studies have to be done for its use on a larger scale. Regarding the materials currently used in direct pulp protection on the market, namely the most recently introduced, further clinical studies are needed.
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Fernandes, Carla Adriana Rebelo. "Citotoxicidade de materiais indicados em proteções pulpares diretas: estudo in vitro." Master's thesis, 2014. http://hdl.handle.net/10316/36290.
Full textAbstract:
Trabalho final do 5º ano com vista à atribuição do grau de mestre no âmbito do ciclo de estudos de Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina da Universidade de Coimbra.Introdução: A avaliação dos materiais dentários tem vindo a demonstrar particular interesse dado, determinados componentes, poderem provocar efeitos citotóxicos em contacto com o complexo dentino-pulpar, aquando dos procedimentos de proteções pulpares. Historicamente vários materiais foram utilizados nesse sentido, incluindo o hidróxido de cálcio, sendo actualmente considerados como “gold standard” os cimentos trióxidos minerais, como o MTA. A introdução de novos materiais semelhantes e com as mesmas indicações clínicas, como o novo cimento à base de silicato de cálcio (Biodentine™), exige a necessidade de testar as suas caraterísticas citotóxicas, até ao momento parcamente investigadas. Objetivo: o objetivo deste estudo experimental é a avaliação da citotoxicidade dos materiais utilizados em proteções pulpares diretas (Life, White ProRoot MTA e Biodentine™) in vitro. Com isto, pretende-se efetuar o estudo comparativo dos materiais através de diferentes parâmetros de avaliação da citotoxicidade. Materiais e métodos: a linha celular de fibroblastos humanos (HFF1) foi incubada com diferentes concentrações de Life, White ProRoot MTA e Biodentine™, utilizando a metodologia dos meios condicionados segundo a norma ISO 10993-5, durante 24, 72 e 120 horas. A avaliação da atividade metabólica foi realizada através do ensaio do MTT, a avaliação do conteúdo proteico foi realizada através do ensaio da sulforrodamina B e a avaliação dos tipos de morte celular foi realizada através do ensaio da citometria de fluxo. Resultados: A citotoxicidade do Life e Biodentine™ diminui com o aumento das diluições, no entanto, ao longo do tempo a citotoxicidade do Life tendencialmente aumenta e a do Biodentine™ diminui. Estes resultados apresentam diferenças estatisticamente significativas em relação ao controlo. O White ProRoot MTA mantém um padrão de biocompatibilidade semelhante em todas as diluições, que tendencialmente aumenta com o tempo. O Life mostrou ser o material mais citotóxico, seguindo-se o Biodentine™ e finalmente o White ProRoot MTA. Conclusão: A atividade metabólica e viabilidade celular dos materiais relaciona-se com as diluições efetuadas e/ou com o tempo de exposição aos meios condicionados. Tal como esperado, o Life devido aos seus padrões de citotoxicidade elevados, não é recomendável para utilização em protecções pulpares diretas. O White ProRoot MTA, devido às sua biocompatibilidade e propriedades que apresenta, demonstra ser um material eficaz e recomendável para esse fim. Quanto ao Biodentine™, apesar de serem previstos níveis de toxicidade semelhantes ao White ProRoot MTA , isso não se verifica para diluições iniciais. Apesar das suas propriedades físicas, tempo de presa e manipulação favoráveis, novos estudos de citotoxicidade devem ser efetuados de modo a utilizá-lo seguramente como uma alternativa viável ao White ProRoot MTA. Introduction: The evaluation of dental materials has shown particular interest because certain components may cause cytotoxic effects in contact with the pulp-dentin complex, when the pulp capping procedure occurs. Historically, various materials were used in this purpose, including calcium hydroxide, however, the trioxides mineral cements (like MTA) are currently considered the gold standard. With the introduction of new materials with equal clinical indications as the new cement based on calcium silicate (Biodentine ™), becomes indispensable to test their cytotoxic patterns, even more so, with the lack of studies regarding this topic. Objective: The aim of this experimental study is to evaluate the cytotoxicity in vitro of direct pulp capping materials (Life, White ProRoot MTA and Biodentine™). With this, we intend to carry out a comparative study of material through different cytotoxicity valuation parameters. Materials and methods: The fibroblast cell line (HFF1) was incubated with different concentrations of Life, White ProRoot MTA and Biodentine™, using extracting techniques according to the ISO 10993-5 standard, during 24, 72 and 120 hours. The assessment of metabolic activity was performed using the MTT assay, the protein content appraisal was performed using the sulforhodamine B assay and the assessment of the cell’s death types was performed with flow cytometry assay. Results: The Biodentine™ and Life cytotoxicity decreases with the increase in dilution, however, over time the cytotoxicity of Life tends to increase while in Biodentine™ it decreases. These results demonstrate statistically significant differences when compared to the control sample. The White ProRoot MTA retains a similar biocompatibility pattern across all the dilutions, which tends to increase over time. Life revealed as the most cytotoxic, followed by Biodentine™ and White ProRoot MTA. Conclusion: The metabolic activity and cell viability of the materials relates with the dilutions realized and/or with the time exposed to conditioned media. As expected, due to the high cytotoxicity levels, Life is not recommended for the use in direct pulp capping. White ProRoot MTA, taking in account its biocompatibility and proprieties demonstrated, is safe to say that it is a type of material adequate to the propose treatment. Referring to Biodentine™, despite being expected toxicity levels similar to White ProRoot MTA, this does not happen for initial dilutions. Although its physical proprieties, setting time and favorable handling, new cytotoxicity studies should be performed in order to use it safely as a viable alternative to White ProRoot MTA.
Books on the topic "Biodentine™"
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About, Imad, ed. Biodentine™. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80932-4.
Full textBook chapters on the topic "Biodentine™"
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Rajasekharan, Sivaprakash. "BiodentineTM: Applications in Pulpotomy of Deciduous Teeth." In Biodentine™, 87–102. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_6.
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Atmeh, Amre R., and Timothy F. Watson. "BiodentineTM Physico-Chemical Properties: From Interactions with Dental Tissues to Ageing." In Biodentine™, 11–30. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_2.
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Galler, Kerstin M., and Tatiana M. Botero. "Clinical Application of BiodentineTM in Regenerative Endodontics/Revitalization." In Biodentine™, 207–21. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_11.
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Widbiller, Matthias, Charlotte Jeanneau, Kerstin M. Galler, Patrick Laurent, and Imad About. "Biocompatibility and Bioactive Properties of BiodentineTM." In Biodentine™, 31–50. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_3.
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Dammaschke, Till, and Mariusz Lipski. "BiodentineTM Applications in Furcation Perforation and Root Resorption." In Biodentine™, 177–206. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_10.
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Bakopoulou, Athina, Anna Koutrouli, and Imad About. "Calcium Silicate-Based Cement (Biodentine™) as a Bioactive Material for the Long-Term Preservation of Pulp Vitality in Restorative Dentistry and Prosthodontics." In Biodentine™, 147–76. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_9.
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Martens, Luc, and Rita Cauwels. "BiodentineTM Applications in Traumatology and Fractures." In Biodentine™, 103–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_7.
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Taha, Nessrin, and Papimon Chompu-inwai. "BiodentineTM Applications in Irreversible Pulpitis Management in Children and Adults." In Biodentine™, 121–46. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_8.
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Banerjee, Avijit, and Montse Mercadé. "BiodentineTM Clinical Applications in Vital Pulp Therapy in Permanent Teeth." In Biodentine™, 67–86. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_5.
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Lundy, Fionnuala T., Thomas Giraud, Ikhlas A. El-Karim, and Imad About. "BiodentineTM in Inflammation and Pain Control." In Biodentine™, 51–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80932-4_4.
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