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1

Bowden, Pye. "Including the body in psychotherapy." Ata: Journal of Psychotherapy Aotearoa New Zealand 7, no. 1 (2001): 65–71. http://dx.doi.org/10.9791/ajpanz.2001.06.

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 This paper describes the development of Bioenergetic Analysis, one of the more recent psychotherapies to arrive in New Zealand. Bioenergetics opens up psychoanalytic theory and practice to include all aspects of the self: the mind, the body, emotion, energy and relationship. In doing so it provides a holistic psychotherapy for the twenty-first century. The paper describes Bioenergetic's beginnings with Wilhelm Reich, a contemporary of Freud, and its establishment by Alexander Lowen. It critiques Bioenergetic's association with the 'cathartic' approach of the 1960s and desc
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2

Sandage, Mary J., and Audrey G. Smith. "Muscle Bioenergetic Considerations for Intrinsic Laryngeal Skeletal Muscle Physiology." Journal of Speech, Language, and Hearing Research 60, no. 5 (2017): 1254–63. http://dx.doi.org/10.1044/2016_jslhr-s-16-0192.

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PurposeIntrinsic laryngeal skeletal muscle bioenergetics, the means by which muscles produce fuel for muscle metabolism, is an understudied aspect of laryngeal physiology with direct implications for voice habilitation and rehabilitation. The purpose of this review is to describe bioenergetic pathways identified in limb skeletal muscle and introduce bioenergetic physiology as a necessary parameter for theoretical models of laryngeal skeletal muscle function.MethodA comprehensive review of the human intrinsic laryngeal skeletal muscle physiology literature was conducted. Findings regarding intr
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3

Lowen, Alexander. "Al Lowen riflette sugli aspetti teorici dell'analisi bioenergetica e sulla sua esperienza negli ultimi quarant'anni." GROUNDING, no. 2 (July 2009): 17–32. http://dx.doi.org/10.3280/gro2008-002003.

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- Alexander Lowen recounts his meeting with Reich, its therapeutic experience with him and the reasons that led him to decide to continue the work of his teacher developing the bioenergetic analysis. As in his costume, biographical and theoretical elements are closely related.Key words: Wilhelm Reich, body, vegetoteraphy, bioenergetic analysisParole chiave: Wilhelm Reich, corpo, vegetoterapia, analisi bioenergetica
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4

Mahapatra, Gargi, Zhengrong Gao, James Bateman, et al. "Systemic Bioenergetic Capacity Changes with Cognitive Status and Insulin Sensitivity in Older Adults." Innovation in Aging 5, Supplement_1 (2021): 638. http://dx.doi.org/10.1093/geroni/igab046.2423.

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Abstract Systemic mitochondrial dysfunction is reported with AD progression, suggesting that peripheral blood cells may be used to investigate systemic mitochondrial alterations related to cognitive decline. We aimed to identify bioenergetic signatures associated with AD-related dementia and differences in insulin sensitivity associated with AD risk. We analyzed mitochondrial bioenergetics in peripheral blood cells collected from 365 older adults with varying cognitive status (normal, mild cognitive impairment, and AD) and insulin sensitivity. Normoglycemic individuals exhibited lower maximal
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5

Mahapatra, Gargi, Jaclyn Bergstrom, Suzanne Craft, and Anthony Molina. "PERIPHERAL BLOOD CELL MITOCHONDRIAL FUNCTIONS ARE ASSOCIATED WITH COGNITIVE PERFORMANCE AND ALZHEIMER’S DISEASE." Innovation in Aging 8, Supplement_1 (2024): 249–50. https://doi.org/10.1093/geroni/igae098.0807.

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Abstract Alzheimer’s disease (AD) dementia associates with systemic mitochondrial bioenergetic decline. We previously showed blood cell mitochondrial bioenergetics recapitulates bioenergetic capacity of highly metabolically active organs like brain, liver, and skeletal muscles, and peripheral blood mononuclear cell (PBMC) mitochondrial function relates to brain morphology. More recently, we examined PBMC and platelet bioenergetics in a cohort of older adults with dementia due to AD. We assessed mitochondrial function using complementary respirometric approaches in intact and permeabilized PBMC
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6

Chacko, Balu K., Philip A. Kramer, Saranya Ravi, et al. "The Bioenergetic Health Index: a new concept in mitochondrial translational research." Clinical Science 127, no. 6 (2014): 367–73. http://dx.doi.org/10.1042/cs20140101.

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Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and pr
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7

Strope, Taylor A., Cole J. Birky, and Heather M. Wilkins. "The Role of Bioenergetics in Neurodegeneration." International Journal of Molecular Sciences 23, no. 16 (2022): 9212. http://dx.doi.org/10.3390/ijms23169212.

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Bioenergetic and mitochondrial dysfunction are common hallmarks of neurodegenerative diseases. Decades of research describe how genetic and environmental factors initiate changes in mitochondria and bioenergetics across Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Mitochondria control many cellular processes, including proteostasis, inflammation, and cell survival/death. These cellular processes and pathologies are common across neurodegenerative diseases. Evidence suggests that mitochondria and bioenergetic disruption may drive pathological chan
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8

Coven, Arnold B. "The Bioenergetic Approach to Rehabilitation Counseling." Journal of Applied Rehabilitation Counseling 16, no. 2 (1985): 6–10. http://dx.doi.org/10.1891/0047-2220.16.2.6.

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The current focus on assisting the severely disabled confronts rehabilitation counselors with the demand of being more effective behavioral change agents. This article suggests that counselors try out Bioenergetics, a mindbody counseling approach. An overview of Bioenergetics theory is presented with examples of how it can be applied to the impaired. Guidelines for using Bioenergetic techniques are identified along with the necessary precautions.
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9

Patón, Mauricio, and Jorge Rodríguez. "Integration of bioenergetics in the ADM1 and its impact on model predictions." Water Science and Technology 80, no. 2 (2019): 339–46. http://dx.doi.org/10.2166/wst.2019.279.

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Abstract In this work, the integration of dynamic bioenergetic calculations in the IWA Anaerobic Digestion Model No. 1 (ADM1) is presented. The impact of bioenergetics on kinetics was addressed via two different approaches: a thermodynamic-based inhibition function and variable microbial growth yields based on dynamic Gibbs free energy calculations. The dynamic bioenergetic calculations indicate that the standard ADM1 predicts positive reaction rates under thermodynamically unfeasible conditions. The dissolved hydrogen inhibition approach used in ADM1 is, however, deemed as adequate, offering
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10

Lehrer, H. Matthew, Lauren Chu, Martica Hall, and Kyle Murdock. "009 Self-Reported Sleep Efficiency and Duration are Associated with Systemic Bioenergetic Function in Community-Dwelling Adults." Sleep 44, Supplement_2 (2021): A4. http://dx.doi.org/10.1093/sleep/zsab072.008.

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Abstract Introduction Sleep is important for aging, health, and disease, but its cellular role in these outcomes is poorly understood. Basic research suggests that disturbed and insufficient sleep impair mitochondrial bioenergetics, which is involved in numerous aging-related chronic conditions. However, the relationship between sleep and bioenergetics has not been examined in humans. We examined associations of self-reported sleep with systemic bioenergetic function in peripheral blood mononuclear cells (PBMCs) of community-dwelling adults. Methods N = 43 adults (79% female) ages 48–70 (M = 6
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11

Hill, Bradford G., Gloria A. Benavides, Jack R. Lancaster, et al. "Integration of cellular bioenergetics with mitochondrial quality control and autophagy." Biological Chemistry 393, no. 12 (2012): 1485–512. http://dx.doi.org/10.1515/hsz-2012-0198.

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Abstract Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of ‘healthy’ mitochondrial populations. The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally, the overall quality of the mitochondrial population and the relative abundance of mitochondria
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12

Cha, Yong-Mei, Petras P. Dzeja, Margaret M. Redfield, Win K. Shen, and Andre Terzic. "Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 4 (2006): H1686—H1692. http://dx.doi.org/10.1152/ajpheart.00384.2005.

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Deficient bioenergetic signaling contributes to myocardial dysfunction and electrical instability in both atrial and ventricular cardiac chambers. Yet, approaches capable to prevent metabolic distress are only partially established. Here, in a canine model of tachycardia-induced congestive heart failure, we compared atrial and ventricular bioenergetics and tested the efficacy of metabolic rescue with the vasopeptidase inhibitor omapatrilat. Despite intrinsic differences in energy metabolism, failing atria and ventricles demonstrated profound bioenergetic deficiency with reduced ATP and creatin
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13

Cockburn, Garry. "«Seeing what is so simply present”." Clinical Journal of the International Institute for Bioenergetic Analysis 23, no. 1 (2013): 75–99. http://dx.doi.org/10.30820/0743-4804-2013-23-75.

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Lowen’s ability to see the body was preternatural. His ability «to see what is so simply present” and to explain the whole personality in terms of the body has been an inspiration for all. Like Lowen, gifted first generation Bioenergetic therapists have generously passed on their knowledge to us. As time passes, so does the opportunity to learn from those who were personally influenced by Lowen. This raises issues of how new students of Bioenergetics can learn and keep the tradition alive. This article discusses these issues and provides a structured way of helping students learn some of the b
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14

Schroeter, Vincentia. "Integrating Regulation Therapy and Bioenergetic Analysis." Clinical Journal of the International Institute for Bioenergetic Analysis 24, no. 1 (2014): 105–32. http://dx.doi.org/10.30820/0743-4804-2014-24-105.

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Attachment theorists have recently become more interested in how bodily-based processes and interventions can contribute to their interest in the emotional regulation of arousal levels. A review of current concepts and techniques in integrative regulation therapy, including their value for Bioenergetics, will be examined. The literature of recent writings on attachment within Bioenergetics will be provided, along with a clinical vignette utilizing both approaches. The paper proposes that the Bioenergetic community answer the call to promote a somatic-energetic approach to the larger psychother
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15

Keane, Kevin N., Emily K. Calton, Vinicius F. Cruzat, Mario J. Soares, and Philip Newsholme. "The impact of cryopreservation on human peripheral blood leucocyte bioenergetics." Clinical Science 128, no. 10 (2015): 723–33. http://dx.doi.org/10.1042/cs20140725.

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Circulating immune cells are considered a source for biomarkers in health and disease, since they are exposed to nutritional, metabolic and immunological stimuli in the vasculature. Cryopreservation of leucocytes is routinely used for long-term storage and determination of phenotypic/functional changes at a later date. Exploring the role of bioenergetics and mitochondrial (dys)function in leucocytes is often examined by using freshly isolated cells. The aim of the pilot study described herein was to assess leucocyte bioenergetics in cryopreserved cells. Leucocytes were isolated from whole bloo
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16

González-Casacuberta, Ingrid, Dolores Vilas, Claustre Pont-Sunyer, et al. "Neuronal induction and bioenergetics characterization of human forearm adipose stem cells from Parkinson’s disease patients and healthy controls." PLOS ONE 17, no. 3 (2022): e0265256. http://dx.doi.org/10.1371/journal.pone.0265256.

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Neurodegenerative diseases, such as Parkinson’s disease, are heterogeneous disorders with a multifactorial nature involving impaired bioenergetics. Stem-regenerative medicine and bioenergetics have been proposed as promising therapeutic targets in the neurologic field. The rationale of the present study was to assess the potential of human-derived adipose stem cells (hASCs) to transdifferentiate into neuronal-like cells (NhASCs and neurospheres) and explore the hASC bioenergetic profile. hASC neuronal transdifferentiation was performed through neurobasal media and differentiation factor exposu
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17

Molina, Anthony. "BIOMARKERS AND DRIVERS OF MITOCHONDRIAL HEALTH AND AGING." Innovation in Aging 8, Supplement_1 (2024): 302. https://doi.org/10.1093/geroni/igae098.0984.

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Abstract In line with the principles of Geroscience, age-associated alterations in mitochondrial function have been shown to underlie a wide array of age-related diseases and conditions. This presentation will review mitochondrial bioenergetic profiling approaches that are being implemented in human/clinical studies. These include tissue and blood-based approaches that can serve as reliable biomarkers of mitochondrial health and have enabled researchers to examine the role of mitochondria in the physical and cognitive abilities of older adults. Importantly, we are also beginning to understand
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18

Shackelford, David B. "Abstract SY35-02: Spatial mapping of mitochondrial networks in lung cancer." Cancer Research 84, no. 7_Supplement (2024): SY35–02—SY35–02. http://dx.doi.org/10.1158/1538-7445.am2024-sy35-02.

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Abstract Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells. The mitochondria form highly organized networks, in which their outer and inner membrane structures define their bioenergetic capacity. However, in vivo studies delineating the relationship between the structural organization of mitochondrial networks and their bioenergetic activity have been limited. Here we present an in vivo structural and functional profiling of mitochondrial networks and bioenergetic phenotypes in non-small cell lung cancer (NSCLC) using an integrated platform comprised o
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19

Tyrrell, Daniel J., Manish S. Bharadwaj, Matthew J. Jorgensen, et al. "Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/7317251.

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Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer’s disease. In this study of nonhuman primates, we focus on mitochondrial function and bioenergetic capacity assessed by the respirometric profiling of monocytes, platelets, and frontal cortex mitochondria. Our data indicate that differences in the maximal respiratory capacity
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20

Nicholls, David G., and Samantha L. Budd. "Mitochondria and Neuronal Survival." Physiological Reviews 80, no. 1 (2000): 315–60. http://dx.doi.org/10.1152/physrev.2000.80.1.315.

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Mitochondria play a central role in the survival and death of neurons. The detailed bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+, generate reactive oxygen species, and undergo Ca2+-dependent permeabilization of their inner membrane are currently being applied to the function of mitochondria in situ within neurons under physiological and pathophysiological conditions. Here we review the functional bioenergetics of isolated mitochondria, with emphasis on the chemiosmotic proton circuit and the application (and occasional misapplication) of these principles
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Grimm, Amandine. "Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation?" Cells 10, no. 10 (2021): 2531. http://dx.doi.org/10.3390/cells10102531.

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The brain is the most energy-consuming organ of the body and impairments in brain energy metabolism will affect neuronal functionality and viability. Brain aging is marked by defects in energetic metabolism. Abnormal tau protein is a hallmark of tauopathies, including Alzheimer’s disease (AD). Pathological tau was shown to induce bioenergetic impairments by affecting mitochondrial function. Although it is now clear that mutations in the tau-coding gene lead to tau pathology, the causes of abnormal tau phosphorylation and aggregation in non-familial tauopathies, such as sporadic AD, remain elus
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Sharapova, Gulnaz, Sirina Sabirova, Marina Gomzikova, et al. "Mitochondrial Protein Density, Biomass, and Bioenergetics as Predictors for the Efficacy of Glioma Treatments." International Journal of Molecular Sciences 25, no. 13 (2024): 7038. http://dx.doi.org/10.3390/ijms25137038.

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The metabolism of glioma cells exhibits significant heterogeneity and is partially responsible for treatment outcomes. Given this variability, we hypothesized that the effectiveness of treatments targeting various metabolic pathways depends on the bioenergetic profiles and mitochondrial status of glioma cells. To this end, we analyzed mitochondrial biomass, mitochondrial protein density, oxidative phosphorylation (OXPHOS), and glycolysis in a panel of eight glioma cell lines. Our findings revealed considerable variability: mitochondrial biomass varied by up to 3.2-fold, the density of mitochon
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23

DiLeo, Matthew R., Rylea E. Hall, Heather L. Vellers, Chelsea L. Daniels, and Danielle E. Levitt. "Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review." International Journal of Molecular Sciences 25, no. 22 (2024): 12280. http://dx.doi.org/10.3390/ijms252212280.

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Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion c
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Phang, Howard, Stephanie Heimler, and Anthony Molina. "CHARACTERIZATION OF AGE-RELATED BIOENERGETIC DECLINE IN HUMAN DERMAL FIBROBLASTS." Innovation in Aging 7, Supplement_1 (2023): 768. http://dx.doi.org/10.1093/geroni/igad104.2482.

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Abstract Progressive mitochondrial dysfunction is a widely recognized hallmark of the human aging process. However, efforts to model bioenergetic decline in vitro largely fail to recapitulate the context of human aging and metabolic physiology, making investigation of age-related bioenergetic decline and targeted interventions difficult. We sought to model human bioenergetic decline in vitro by profiling the respiratory capacity of cultured human dermal fibroblasts from donors across the adult human lifespan. Primary human dermal fibroblasts (pHDF) are an attractive in vitro model to assess ag
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Kumar, Parveen, Robert A. Oster, Dean G. Assimos, Timothy J. Ness, and Tanecia Mitchell. "Bioenergetic profiles of peripheral mononuclear cells and systemic inflammation in women with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)." PLOS ONE 19, no. 2 (2024): e0298981. http://dx.doi.org/10.1371/journal.pone.0298981.

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Inflammation is thought to contribute to the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS). It is well-known that disruption in metabolism in immune cells contributes to inflammation in several inflammatory diseases. The purpose of this study was to investigate whether cellular bioenergetics is altered in monocytes and lymphocytes from women with IC/BPS, and if these alterations correlate with systemic inflammatory markers. Age and BMI matched adult healthy women (HS; n = 18) and women with IC/BPS (n = 18) were included in the study. Blood was collected to assess cellular bi
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26

Cardenuto, Léia M. "Creativity and Grounding in a Liquid World." Clinical Journal of the International Institute for Bioenergetic Analysis 24, no. 1 (2014): 85–103. http://dx.doi.org/10.30820/0743-4804-2014-24-85.

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After more than 14 years dwelling with the challenges of a Social Clinic in Focused Bioenergetics we intend to share our experience with the bioenergetic therapists community. In all those years we have learned much about the difficulties of establishing a line of work suitable to use the bioenergetic approach with troubled people in troubled social environments, in particular those outside of our consumer society. We had to rely more on a progressive approach than on a regressive one in order to bring the analytical process to a successful outcome, consistent with the focused bioenergetics me
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Acin-Perez, Rebeca, Cristiane Benincá, Byourak Shabane, Orian S. Shirihai, and Linsey Stiles. "Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives." Life 11, no. 9 (2021): 949. http://dx.doi.org/10.3390/life11090949.

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Mitochondrial bioenergetic function is a central component of cellular metabolism in health and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic homeostasis, and impairment of mitochondrial function underlies the development and progression of metabolic diseases and aging. However, measurement of mitochondrial bioenergetic function can be challenging in human samples due to limitations in the size of the collected sample. Furthermore, the collection of samples from human cohorts is often spread over multiple days and locations, which makes immediate sample
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Castillo, Rodrigo L., Emilio A. Herrera, Alejandro Gonzalez-Candia, et al. "Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–14. http://dx.doi.org/10.1155/2018/7239123.

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Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in the cardiac function under glycemic control deficiency conditions. This work aimed to determine the cardioprotective effects of quercetin (QUE) against the damage induced by a high-cholesterol (HC) diet in hyperglycemic rats, addressing intracellular antioxidant mechanisms and bioenergetics. Quercetin reduced HC-induced alterations in the lipid profile and glycemia in rats. I
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Pandya, Jignesh D., Matthew Valdez, Joyce E. Royland, Robert C. MacPhail, Patrick G. Sullivan, and Prasada Rao S. Kodavanti. "Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats." Journal of Aging Research 2020 (April 1, 2020): 1–11. http://dx.doi.org/10.1155/2020/7232614.

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Mitochondria play a central role in energy homeostasis and act as regulatory checkpoints for downstream metabolic responses and cell senescence processes during an entire life span. Acute or chronic environmental toxicant exposures have shown deleterious organ-specific human health issues at various life stages. Since mitochondria are a prime target for ensuing cellular bioenergetics responses and senescence, it is essential to understand mitochondrial bioenergetic responses in different organs over multiple life stages. Therefore, in the present study, we evaluated mitochondrial bioenergetic
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Armstrong, Jane A., Nicole J. Cash, Yulin Ouyang, et al. "Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift." Journal of Biological Chemistry 293, no. 21 (2018): 8032–47. http://dx.doi.org/10.1074/jbc.ra118.003200.

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Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca2+-dependent formation of the mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D (CypD), the formation of which causes ATP depletion and necrosis. Oxidative stress reportedly triggers MPTP formation and is elevated in clinical AP, but how reactive oxygen species influence cell death is unclear. Here, we assessed potential MPTP involvement in oxidant-induced effects on pancreatic acinar cell bioenergetics and fate. H2O2 application promoted acinar cell a
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Kovacevic, Bozica, Corina Mihaela Ionescu, Melissa Jones, et al. "The Effect of Deoxycholic Acid on Chitosan-Enabled Matrices for Tissue Scaffolding and Injectable Nanogels." Gels 8, no. 6 (2022): 358. http://dx.doi.org/10.3390/gels8060358.

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The pathophysiology of a multitude of diseases is influenced by bioenergetic dysfunction. Healthy mitochondria are presented as essential for the regulation and function of multiple cell types, including the cells of relevance for this research: pancreatic beta cells, muscle cells, and liver cells. Hence, effects of hydrogels (particularly nanogels) on bioenergetics needs to be taken into account when designing optimum delivery matrices. Several polymers have been suggested for use in hydrogels and nanogels, with focus on chitosan due to its range of beneficial properties. Bile acids have emer
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Martino Adami, Pamela V., Celia Quijano, Natalia Magnani, et al. "Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease." Journal of Cerebral Blood Flow & Metabolism 37, no. 1 (2016): 69–84. http://dx.doi.org/10.1177/0271678x15615132.

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Synaptic bioenergetic deficiencies may be associated with early Alzheimer's disease (AD). To explore this concept, we assessed pre-synaptic mitochondrial function in hemizygous (+/−)TgMcGill-R-Thy1-APP rats. The low burden of Aβ and the wide array of behavioral and cognitive impairments described in 6-month-old hemizygous TgMcGill-R-Thy1-APP rats (Tg(+/−)) support their use to investigate synaptic bioenergetics deficiencies described in subjects with early Alzheimer's disease (AD). In this report, we show that pre-synaptic mitochondria from Tg(+/−) rats evidence a decreased respiratory control
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Davies, Karen M., and Bertram Daum. "Role of cryo-ET in membrane bioenergetics research." Biochemical Society Transactions 41, no. 5 (2013): 1227–34. http://dx.doi.org/10.1042/bst20130029.

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To truly understand bioenergetic processes such as ATP synthesis, membrane-bound substrate transport or flagellar rotation, systems need to be analysed in a cellular context. Cryo-ET (cryo-electron tomography) is an essential part of this process, as it is currently the only technique which can directly determine the spatial organization of proteins at the level of both the cell and the individual protein complexes. The need to assess bioenergetic processes at a cellular level is becoming more and more apparent with the increasing interest in mitochondrial diseases. In recent years, cryo-ET ha
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Valenti, Daniela, Fiorenza Stagni, Marco Emili, Sandra Guidi, Renata Bartesaghi, and Rosa Anna Vacca. "Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone." Antioxidants 11, no. 1 (2021): 62. http://dx.doi.org/10.3390/antiox11010062.

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Down syndrome (DS), a major genetic cause of intellectual disability, is characterized by numerous neurodevelopmental defects. Previous in vitro studies highlighted a relationship between bioenergetic dysfunction and reduced neurogenesis in progenitor cells from the Ts65Dn mouse model of DS, suggesting a critical role of mitochondrial dysfunction in neurodevelopmental alterations in DS. Recent in vivo studies in Ts65Dn mice showed that neonatal supplementation (Days P3–P15) with the polyphenol 7,8-dihydroxyflavone (7,8-DHF) fully restored hippocampal neurogenesis. The current study was aimed t
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35

Schroeter, Vincentia. "Borderline Character Structure Revisited." Clinical Journal of the International Institute for Bioenergetic Analysis 19, no. 1 (2009): 31–51. http://dx.doi.org/10.30820/0743-4804-2009-19-31.

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Review and revision of borderline character type etiology and dynamics from bioenergetic point of view. Exploring revisions and offering new theories related to body-type, age, major blocks, and continuum on developmental phases chart from object relations schema. Included are views from prevailing theories in psychology and within bioenergetics as well as from a current scientific study. Treatment aspects are discussed and relational interventions included.
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Esparza, Orlando, Giovanny Hernandez, Rachelle Nuss, et al. "The Therapeutic Modalities of Sickle Cell Disease Reprogram the Platelet Functional-Bioenergetic Profile." Blood 138, Supplement 1 (2021): 957. http://dx.doi.org/10.1182/blood-2021-153908.

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Abstract BACKGROUND: Sickle cell disease (SCD) is a group of inherited hemoglobinopathies that continues to be highly morbid and lethal. SCD-associated platelet hyperreactivity is a well-recognized contributor to the pathophysiology of the disease via complex interactions with the immune system and endothelium. Aberrant platelet bioenergetics have been implicated as a biological mechanism for SCD-associated platelet hyperreactivity, however, little is known about the impact current medical interventions (e.g., hydroxyurea [HU] and red blood cell [RBC] exchange transfusions) have on the platele
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37

Swerdlow, Russell H. "Bioenergetic medicine." British Journal of Pharmacology 171, no. 8 (2014): 1854–69. http://dx.doi.org/10.1111/bph.12394.

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38

Munroe, Alex. "The Role of Bioenergetic Supervision in Bioenergetic Training." Clinical Journal of the International Institute for Bioenergetic Analysis 19, no. 1 (2009): 101–12. http://dx.doi.org/10.30820/0743-4804-2009-19-101.

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Supervision plays a key role in a trainee’s movement towards certification as a Bioenergetic Therapist. It is therefore important to clearly understand and discuss the components of Bioenergetic supervision. Some commonalities for supervision in psychology, social work and Bioenergetic Analysis are set out. Aspects of supervision that are unique to Bioenergetic Analysis are identified. The paper concludes with an exercise to help the reader experience some of the Bioenergetic concepts presented. The paper is a beginning attempt to contribute to this discussion.
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39

Hafstad, Arild. "The Mysterious Life Energy." Clinical Journal of the International Institute for Bioenergetic Analysis 28, no. 1 (2018): 27–43. http://dx.doi.org/10.30820/0743-4804-2018-28-27.

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The paper explores empirical validation of the bioenergetic concept by randomized controlled research on the orgone box. To improve concept validity the author anchors the bioenergetic concept in physical principles and metabolism, combined with principles from Bioenergetic Analysis. The research lends support to the bioenergetic concept by showing that «contextual” stimulation (in the orgone box) can increase free energy in the human organism, indicating influence on a human bioenergetic system. These studies show that the human bioenergetic system is under contextual influence. The orgone th
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40

Augsburger, Fiona, Elisa B. Randi, Mathieu Jendly, Kelly Ascencao, Nahzli Dilek, and Csaba Szabo. "Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells." Biomolecules 10, no. 3 (2020): 447. http://dx.doi.org/10.3390/biom10030447.

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3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. The current study was designed to investigate the functional role of 3-MST’s catalytic activity in the murine colon cancer cell line CT26. The novel pharmacological 3-MST inhibitor HMPSNE was used to assess cancer cell proliferation, migration and bioenergetics in vitro. Methods included measurements of cell viability (MTT and LDH assays), cell proliferation and in vitro wound healing (IncuCyte) and cellular bioenergetics (Seahorse extrace
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41

Liu, Haoming, Yingying Du, Jean-Philippe St-Pierre, et al. "Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state." Science Advances 6, no. 13 (2020): eaay7608. http://dx.doi.org/10.1126/sciadv.aay7608.

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Cellular bioenergetics (CBE) plays a critical role in tissue regeneration. Physiologically, an enhanced metabolic state facilitates anabolic biosynthesis and mitosis to accelerate regeneration. However, the development of approaches to reprogram CBE, toward the treatment of substantial tissue injuries, has been limited thus far. Here, we show that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold compared to commercialized poly(lactic acid) and calcium phosphate ceramic scaffolds. This material was composed o
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42

Kerr, S. R., and L. M. Dickie. "Bioenergetics of O+ Atlantic Herring (Clupea harengus harengus)." Canadian Journal of Fisheries and Aquatic Sciences 42, S1 (1985): s105—s110. http://dx.doi.org/10.1139/f85-266.

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On the basis of the limited published information on herring bioenergetics, together with general considerations from other species, we propose a preliminary bioenergetic model for Atlantic herring (Clupea harengus harengus). Application of the model to published data for five larval cohorts from each of two years shows that temperature and body size interact with the apparent availability of suitable prey to result in quite different metabolic environments that support relatively uniform growth.
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43

Adekunbi, Daniel, Cun Li, Peter Nathanielsz, and Adam Salmon. "SEX DIFFERENCES IN MITOCHONDRIAL RESILIENCE: EVIDENCE FROM BABOON HEPATOCYTES." Innovation in Aging 6, Supplement_1 (2022): 813. http://dx.doi.org/10.1093/geroni/igac059.2928.

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Abstract Events that occur in utero set the trajectory for later-life diseases and longevity. Compelling data exist for interactions between developmental programming and aging, but the underlying mechanisms are not clearly defined. Fetal exposure to glucocorticoids (GC) is associated with alteration in hepatic enzymes and metabolic function in later life. We previously reported increased hepatic lipid accumulation and obese phenotype in middle-age male baboons exposed to GC as fetuses. The mitochondria play significant roles in cellular processes including stress responses and possibly a nexu
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Affourtit, Charles, Ben Alberts, Jonathan Barlow, Jane E. Carré та Anthony G. Wynne. "Control of pancreatic β-cell bioenergetics". Biochemical Society Transactions 46, № 3 (2018): 555–64. http://dx.doi.org/10.1042/bst20170505.

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The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual as it implies that ATP flux is governed, to a significant extent, by ATP supply, while it is predominantly demand-driven in other cell types. Metabolic control is generally shared between different processes, but potential control of ATP consumption over β-cell bioenergetics has been largely ignored to date. The present paper offers a brief overview of experimental evidence that demons
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Fan, Yang-Yi, Laurie A. Davidson, Evelyn S. Callaway, Gus A. Wright, Stephen Safe, and Robert S. Chapkin. "A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 309, no. 1 (2015): G1—G9. http://dx.doi.org/10.1152/ajpgi.00052.2015.

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Evidence suggests that targeting cancer cell energy metabolism might be an effective therapeutic approach for selective ablation of malignancies. Using a Seahorse Extracellular Flux Analyzer, we have demonstrated that select environmental agents can alter colonic mitochondrial function by increasing respiration-induced proton leak, thereby inducing apoptosis, a marker of colon cancer risk. To further probe bioenergetics in primary intestinal cells, we developed methodology that can be modified and adapted to measure the bioenergetic profiles of colonic crypts, the basic functional unit of the
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Cegatti, Julia, and Leticia Polosecki. "Uses of the Sphere as a Motherfied Object in Bioenergetic Analysis." Clinical Journal of the International Institute for Bioenergetic Analysis 28, no. 1 (2018): 99–118. http://dx.doi.org/10.30820/0743-4804-2018-28-99.

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In this article we are going to present a «Biospheres” practice. It evolved as a result of integrating our formative experiences in Bioenergetics Analysis with the «Dynamic Sphere Postural Reorganization” (Esferodinamia Reorganización Postural, which will be referred to as «RP” technique). We describe the sphere (large rubber ball) qualities and how it can be helpful for body psychotherapy interventions. Finally, we look into two cases using this clinical tool. The sphere becomes an element that facilitates clinical and educational work in the contemporary Bioenergetic field.
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Bettinazzi, Stefano, Liliana Milani, Pierre U. Blier, and Sophie Breton. "Bioenergetic consequences of sex-specific mitochondrial DNA evolution." Proceedings of the Royal Society B: Biological Sciences 288, no. 1957 (2021): 20211585. http://dx.doi.org/10.1098/rspb.2021.1585.

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Doubly uniparental inheritance (DUI) represents a notable exception to the general rule of strict maternal inheritance (SMI) of mitochondria in metazoans. This system entails the coexistence of two mitochondrial lineages (F- and M-type) transmitted separately through oocytes and sperm, thence providing an unprecedented opportunity for the mitochondrial genome to evolve adaptively for male functions. In this study, we explored the impact of a sex-specific mitochondrial evolution upon gamete bioenergetics of DUI and SMI bivalve species, comparing the activity of key enzymes of glycolysis, fermen
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Osorio, Teresa, Ernest R. Scoma, Daniel H. Shain, et al. "The Glacier Ice Worm, Mesenchytraeus solifugus, Elevates Mitochondrial Inorganic Polyphosphate (PolyP) Levels in Response to Stress." Biology 11, no. 12 (2022): 1771. http://dx.doi.org/10.3390/biology11121771.

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The inorganic polymer, polyphosphate (polyP), is present in all organisms examined to date with putative functions ranging from the maintenance of bioenergetics to stress resilience and protein homeostasis. Bioenergetics in the glacier-obligate, segmented worm, Mesenchytraeus solifugus, is characterized by a paradoxical increase in intracellular ATP levels as temperatures decline. We show here that steady-state, mitochondrial polyP levels vary among species of Annelida, but were elevated only in M. solifugus in response to thermal stress. In contrast, polyP levels decreased with temperature in
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Nesbeth, Paula-Dene, Thomas Ziegler, Daiana Weiss, et al. "Linoleic Acid Reduces Oxidative Phosphorylation and Impairs Early Differentiation of MC3T3-E1 Osteoblast Precursor Cells." Current Developments in Nutrition 6, Supplement_1 (2022): 452. http://dx.doi.org/10.1093/cdn/nzac057.018.

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Abstract Objectives Untargeted metabolomics analyses by our group have shown that plasma linoleic acid (LA) was inversely associated with bone mineral density Z-score and that bone formation indices were associated with energy-generating metabolic pathways, including fatty acid b-oxidation, in adult cohorts. Here, we examined the effect of increasing LA concentrations on osteoblast precursor cell bioenergetics and osteoblast differentiation to determine whether high LA is detrimental to bone formation. Methods We treated MC3T3-E1 pre-osteoblastic cells with 0 µM (control), 1 μM, and 50 μM LA c
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Tasche, Jens. "Self-Regulation and Psychodynamics in Bioenergetic Analysis." Clinical Journal of the International Institute for Bioenergetic Analysis 31, no. 1 (2021): 59–78. http://dx.doi.org/10.30820/0743-4804-2021-31-59.

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This article presents ten theses containing theoretical considerations for a postgraduate curriculum as currently tested by the Polish Society for Bioenergetic Analysis. The bioenergetic notion of the self, of affect regulation and of mental defense are modified in order to allow for psychodynamic conflict-, structureand trauma-pathological concepts to be integrated into Bioenergetic Analysis. Among other advantages, this approach facilitates the work with structural disorders (narcissism, borderline personality disorder) in Bioenergetic Analysis.
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