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Journal articles on the topic 'Bioenergetics – Research'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Chacko, Balu K., Philip A. Kramer, Saranya Ravi, et al. "The Bioenergetic Health Index: a new concept in mitochondrial translational research." Clinical Science 127, no. 6 (2014): 367–73. http://dx.doi.org/10.1042/cs20140101.

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Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and pr

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Davies, Karen M., and Bertram Daum. "Role of cryo-ET in membrane bioenergetics research." Biochemical Society Transactions 41, no. 5 (2013): 1227–34. http://dx.doi.org/10.1042/bst20130029.

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To truly understand bioenergetic processes such as ATP synthesis, membrane-bound substrate transport or flagellar rotation, systems need to be analysed in a cellular context. Cryo-ET (cryo-electron tomography) is an essential part of this process, as it is currently the only technique which can directly determine the spatial organization of proteins at the level of both the cell and the individual protein complexes. The need to assess bioenergetic processes at a cellular level is becoming more and more apparent with the increasing interest in mitochondrial diseases. In recent years, cryo-ET ha

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Acin-Perez, Rebeca, Cristiane Benincá, Byourak Shabane, Orian S. Shirihai, and Linsey Stiles. "Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives." Life 11, no. 9 (2021): 949. http://dx.doi.org/10.3390/life11090949.

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Mitochondrial bioenergetic function is a central component of cellular metabolism in health and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic homeostasis, and impairment of mitochondrial function underlies the development and progression of metabolic diseases and aging. However, measurement of mitochondrial bioenergetic function can be challenging in human samples due to limitations in the size of the collected sample. Furthermore, the collection of samples from human cohorts is often spread over multiple days and locations, which makes immediate sample

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Strope, Taylor A., Cole J. Birky, and Heather M. Wilkins. "The Role of Bioenergetics in Neurodegeneration." International Journal of Molecular Sciences 23, no. 16 (2022): 9212. http://dx.doi.org/10.3390/ijms23169212.

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Bioenergetic and mitochondrial dysfunction are common hallmarks of neurodegenerative diseases. Decades of research describe how genetic and environmental factors initiate changes in mitochondria and bioenergetics across Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Mitochondria control many cellular processes, including proteostasis, inflammation, and cell survival/death. These cellular processes and pathologies are common across neurodegenerative diseases. Evidence suggests that mitochondria and bioenergetic disruption may drive pathological chan

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Lehrer, H. Matthew, Lauren Chu, Martica Hall, and Kyle Murdock. "009 Self-Reported Sleep Efficiency and Duration are Associated with Systemic Bioenergetic Function in Community-Dwelling Adults." Sleep 44, Supplement_2 (2021): A4. http://dx.doi.org/10.1093/sleep/zsab072.008.

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Abstract Introduction Sleep is important for aging, health, and disease, but its cellular role in these outcomes is poorly understood. Basic research suggests that disturbed and insufficient sleep impair mitochondrial bioenergetics, which is involved in numerous aging-related chronic conditions. However, the relationship between sleep and bioenergetics has not been examined in humans. We examined associations of self-reported sleep with systemic bioenergetic function in peripheral blood mononuclear cells (PBMCs) of community-dwelling adults. Methods N = 43 adults (79% female) ages 48–70 (M = 6

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Shackelford, David B. "Abstract SY35-02: Spatial mapping of mitochondrial networks in lung cancer." Cancer Research 84, no. 7_Supplement (2024): SY35–02—SY35–02. http://dx.doi.org/10.1158/1538-7445.am2024-sy35-02.

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Abstract Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells. The mitochondria form highly organized networks, in which their outer and inner membrane structures define their bioenergetic capacity. However, in vivo studies delineating the relationship between the structural organization of mitochondrial networks and their bioenergetic activity have been limited. Here we present an in vivo structural and functional profiling of mitochondrial networks and bioenergetic phenotypes in non-small cell lung cancer (NSCLC) using an integrated platform comprised o

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Pietrangelo, Donatella, Caroline Lopa, Margherita Litterio, Maria Cotugno, Speranza Rubattu, and Angela Lombardi. "Metabolic Disturbances Involved in Cardiovascular Diseases: The Role of Mitochondrial Dysfunction, Altered Bioenergetics and Oxidative Stress." International Journal of Molecular Sciences 26, no. 14 (2025): 6791. https://doi.org/10.3390/ijms26146791.

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The study of metabolic abnormalities regarding mitochondrial respiration and energy production has significantly advanced our understanding of cell biology and molecular mechanisms underlying cardiovascular diseases (CVDs). Mitochondria provide 90% of the energy required for maintaining normal cardiac function and are central to heart bioenergetics. During the initial phase of heart failure, mitochondrial number and function progressively decline, causing a decrease in oxidative metabolism and increased glucose uptake and glycolysis, leading to ATP depletion and bioenergetic starvation, finall

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Drahota, Z., J. Houštěk, and A. Pecinová. "Czech Footprints in the Bioenergetics Research." Physiological Research, Suppl 1 (August 31, 2024): S23—S33. http://dx.doi.org/10.33549/physiolres.935395.

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Life manifests as growth, movement or heat production that occurs thanks to the energy accepted from the outside environment. The basis of energy transduction attracted the Czech researchers since the beginning of the 20th century. It further accelerated after World War II, when the new Institute of Physiology was established in 1954. When it was found that energy is stored in the form of adenosine triphosphate (ATP) that can be used by numerous reactions as energy source and is produced in the process called oxidative phosphorylation localized in mitochondria, the investigation focused on thi

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Riddle, Ryan C., and Thomas L. Clemens. "Bone Cell Bioenergetics and Skeletal Energy Homeostasis." Physiological Reviews 97, no. 2 (2017): 667–98. http://dx.doi.org/10.1152/physrev.00022.2016.

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The rising incidence of metabolic diseases worldwide has prompted renewed interest in the study of intermediary metabolism and cellular bioenergetics. The application of modern biochemical methods for quantitating fuel substrate metabolism with advanced mouse genetic approaches has greatly increased understanding of the mechanisms that integrate energy metabolism in the whole organism. Examination of the intermediary metabolism of skeletal cells has been sparked by a series of unanticipated observations in genetically modified mice that suggest the existence of novel endocrine pathways through

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Torres-Quesada, Omar, Carolina Doerrier, Sophie Strich, Erich Gnaiger, and Eduard Stefan. "Physiological Cell Culture Media Tune Mitochondrial Bioenergetics and Drug Sensitivity in Cancer Cell Models." Cancers 14, no. 16 (2022): 3917. http://dx.doi.org/10.3390/cancers14163917.

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Two-dimensional cell cultures are established models in research for studying and perturbing cell-type specific functions. However, many limitations apply to the cell growth in a monolayer using standard cell culture media. Although they have been used for decades, their formulations do not mimic the composition of the human cell environment. In this study, we analyzed the impact of a newly formulated human plasma-like media (HPLM) on cell proliferation, mitochondrial bioenergetics, and alterations of drug efficacies using three distinct cancer cell lines. Using high-resolution respirometry, w

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Srivastava, Rupesh K., Leena Sapra, and Pradyumna K. Mishra. "Osteometabolism: Metabolic Alterations in Bone Pathologies." Cells 11, no. 23 (2022): 3943. http://dx.doi.org/10.3390/cells11233943.

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Renewing interest in the study of intermediate metabolism and cellular bioenergetics is brought on by the global increase in the prevalence of metabolic illnesses. Understanding of the mechanisms that integrate energy metabolism in the entire organism has significantly improved with the application of contemporary biochemical tools for quantifying the fuel substrate metabolism with cutting-edge mouse genetic procedures. Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. These findings point to the poss

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Yoon, HongGyu, Junseong Park, Seo Jin Kim, et al. "RADT-28. DISRUPTION OF BIOENERGETICS ENHANCES RADIO-SENSITIVITY OF PATIENT-DERIVED GLIOBLASTOMA TUMORSPHERES." Neuro-Oncology 25, Supplement_5 (2023): v54—v55. http://dx.doi.org/10.1093/neuonc/noad179.0217.

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Abstract INTRODUCTION Glioblastoma (GBM), the most common primary brain tumor, has been associated with poor prognosis despite various treatment modalities, the surgical resection accompanied by chemotherapy and radiotherapy. Although the importance of radiotherapy is well known, its combination with bioenergetics regulators has not been established in clinical practice. Here, we hypothesized that bioenergetics regulators improve the radio-sensitivity of GBM-tumorspheres (TS). METHODS Gene expression profiles of GBM patient-derived TSs were obtained from microarray. In vitro efficacies of the

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Resneck-Sannes, Helen. "The Embodied Mind." Clinical Journal of the International Institute for Bioenergetic Analysis 17, no. 1 (2007): 39–56. http://dx.doi.org/10.30820/0743-4804-2007-17-39.

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Focus is on the salient aspects of neurobiological research, which are relevant for psychotherapy and particularly for Bioenergetics. This research concludes that the brain informs the body and the body in turn informs and sculpts the brain. The implications of this finding are discussed in relation to the Bioenergetic theory of character development. A brief overview of the anatomy and functions of the brain is presented with references to theories regarding the processing of traumatic memories. Finally, a more in-depth analysis of some of the findings from neuroscientific investigations are

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Saks, Valdur. "Molecular System Bioenergetics—New Aspects of Metabolic Research." International Journal of Molecular Sciences 10, no. 8 (2009): 3655–57. http://dx.doi.org/10.3390/ijms10083655.

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Liebers, David T., Wataru Ebina, and Dan V. Iosifescu. "Sodium-Glucose Cotransporter-2 Inhibitors in Depression." Harvard Review of Psychiatry 31, no. 4 (2023): 214–21. http://dx.doi.org/10.1097/hrp.0000000000000374.

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Abstract Novel treatment strategies that refract existing treatment algorithms for depressive disorders are being sought. Abnormal brain bioenergetic metabolism may represent an alternative, therapeutically targetable neurobiological basis for depression. A growing body of research points to endogenous ketones as candidate neuroprotective metabolites with the potential to enhance brain bioenergetics and improve mood. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally approved for the treatment of diabetes, induce ketogenesis and are associated with mood improvement in population-bas

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Frattaruolo, Luca, Graziantonio Lauria, Francesca Aiello, et al. "Exploiting Glycyrrhiza glabra L. (Licorice) Flavanones: Licoflavanone’s Impact on Breast Cancer Cell Bioenergetics." International Journal of Molecular Sciences 25, no. 14 (2024): 7907. http://dx.doi.org/10.3390/ijms25147907.

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Research on the energy metabolism of cancer cells is becoming a central element in oncology, and in recent decades, it has allowed us to better understand the mechanisms underlying the onset and chemoresistance of oncological pathologies. Mitochondrial bioenergetic processes, in particular, have proven to be fundamental for the survival of tumor stem cells (CSC), a subpopulation of tumor cells responsible for tumor recurrence, the onset of metastasis, and the failure of conventional anticancer therapies. Over the years, numerous natural products, in particular flavonoids, widely distributed in

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Pillai, Rashmi, Xiaoyu Zhang, and Yama Abassi. "Abstract 3248: Metabolic rewiring shifts engineered TCR T cell bioenergetics to enhance cytotoxicity." Cancer Research 84, no. 6_Supplement (2024): 3248. http://dx.doi.org/10.1158/1538-7445.am2024-3248.

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Abstract Background: Adoptive T cell-based transfer has shown tremendous success in hematological cancers. However, an important obstacle to using cell and gene therapy for solid tumors is the aggressive tumor microenvironment (TME). To significantly improve prognosis of subjects undergoing immunotherapy, it is essential to incorporate unique methods to drive T cell energy production and metabolism towards empowering T cells to dismantle the suppressive TME. This can promote anti-tumor effects and persistence of the transfused engineered T cells. In the present study we present a simple metabo

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Sultanova, Regina F., Ryan Schibalski, Irina A. Yankelevich, Krisztian Stadler, and Daria V. Ilatovskaya. "Sex differences in renal mitochondrial function: a hormone-gous opportunity for research." American Journal of Physiology-Renal Physiology 319, no. 6 (2020): F1117—F1124. http://dx.doi.org/10.1152/ajprenal.00320.2020.

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Sex differences (biological distinctions between males and females) present a complex interplay of genetic, developmental, biological, and environmental factors. More and more studies are shedding light on the importance of sex differences in normal physiology and susceptibility to cancer, cardiovascular and renal conditions, and neurodegenerative diseases. This mini-review is devoted to the role of sex dimorphisms in renal function, with a focus on the distinctions between male and female mitochondria. Here, we cover the aspects of renal mitochondrial bioenergetics where sex differences have

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Espino, Camille Lozano. "Enhancing Students’ Conceptual Understanding on Bioenergetics through BEEP Cards." International Journal of Research in Education and Science 10, no. 3 (2024): 543–60. http://dx.doi.org/10.46328/ijres.3471.

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The study examined the effectiveness of BEEP Cards (BioEnergetics Enhancement Play Cards) on students’ conceptual understanding of bioenergetics. The study involved one group of grade 11 students (n=29) from a public secondary school in the Philippines. The study employed a mixed-method research design, utilizing both quantitative and qualitative data to answer the research questions. Specifically, a one-group pretest-posttest action research design was used in this study. The study used a six-week exposure to the use of BEEP Cards. The quantitative data were obtained from a researcher-made an

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Cooper, Chris. "The return of the mitochondrion." Biochemist 27, no. 3 (2005): 5–6. http://dx.doi.org/10.1042/bio02703005.

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For a fresh-faced (well, apart from the beard) PhD graduate in 1989, mitochondrial bioenergetics might have seemed a strange choice of research path. Flushed with the general acceptance of the chemiosmotic theory, many felt that the area had passed its heyday. With the publication of its ‘bible’ (Bioenergetics, the definitive textbook by David Nicholls)1 the field, if not history, had come to a .

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Kovacevic, Bozica, Corina Mihaela Ionescu, Melissa Jones, et al. "The Effect of Deoxycholic Acid on Chitosan-Enabled Matrices for Tissue Scaffolding and Injectable Nanogels." Gels 8, no. 6 (2022): 358. http://dx.doi.org/10.3390/gels8060358.

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The pathophysiology of a multitude of diseases is influenced by bioenergetic dysfunction. Healthy mitochondria are presented as essential for the regulation and function of multiple cell types, including the cells of relevance for this research: pancreatic beta cells, muscle cells, and liver cells. Hence, effects of hydrogels (particularly nanogels) on bioenergetics needs to be taken into account when designing optimum delivery matrices. Several polymers have been suggested for use in hydrogels and nanogels, with focus on chitosan due to its range of beneficial properties. Bile acids have emer

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Roy Chowdhury, Subir, Eric D. J. Bouchard, Ryan Saleh, et al. "Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment." Cancers 12, no. 3 (2020): 650. http://dx.doi.org/10.3390/cancers12030650.

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Mitochondrial bioenergetics profiling, a measure of oxygen consumption rates, correlates with prognostic markers and can be used to assess response to therapy in chronic lymphocytic leukemia (CLL) cells. In this study, we measured mitochondrial respiration rates in primary CLL cells using respirometry to evaluate mitochondrial function. We found significant increases in mitochondrial respiration rates in CLL versus control B lymphocytes. We also observed amongst CLL patients that advanced age, female sex, zeta-chain-associated protein of 70 kD (ZAP-70+), cluster of differentiation 38 (CD38+),

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Obre, Emilie, and Rodrigue Rossignol. "Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy." International Journal of Biochemistry & Cell Biology 59 (February 2015): 167–81. http://dx.doi.org/10.1016/j.biocel.2014.12.008.

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Grishin, A. P., A. A. Grishin, and V. A. Grishin. "Research Results of Bioenergetics Factors Influence on Crop Production Yields Increase." Agricultural machinery and technologies 12, no. 2 (2018): 19–25. http://dx.doi.org/10.22314/2073-7599-2018-12-2-19-25.

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Caamaño-Teixeira, S., C. Iglesias, V. Gonzalez-Alvarez, V. Arce, J. Costoya, and R. Señaris. "P10.36.B ROLE OF AMPK IN GLIOBLASTOMA BIOENERGETICS." Neuro-Oncology 25, Supplement_2 (2023): ii71. http://dx.doi.org/10.1093/neuonc/noad137.234.

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Abstract BACKGROUND Glioblastoma is the most prevalent and aggressive primary brain tumor. AMP-activated kinase (AMPK), the main energy sensor of the cell, has been previously described by our group as a key factor in glioblastoma oncogenesis and proliferation and is known for taking part in tumoral metabolic transformation. Our group has also formerly reported how AMPK regulates the expression of lipoprotein receptors and alters lipid reliance of glioblastoma cells, suggesting AMPK orchestrates nutrient dependency and flexibility on glioblastoma. Overall, this evidence positions AMPK inhibiti

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Ohnishi, Tomoko, and S. Tsuyoshi Ohnishi. "A new trend in the complex I research field." Biological Chemistry 394, no. 5 (2013): 677–83. http://dx.doi.org/10.1515/hsz-2013-0117.

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Abstract To date, the 17th European Bioenergetics Conference (EBEC) in Freiburg, Germany (September 15–20, 2012) was the most exciting conference for the complex I (NADH-Q oxidoreductase) research field. A whole day of oral presentations was dedicated to complex I, including three plenary lectures and 11 symposium talks. In addition, 43 posters were dedicated to complex I projects. Here is a brief summary of an exciting paradigm shift from ‘structure major’ to ‘structure plus function’, clearly observed in the complex I research field.

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Roy Chowdhury, Subir, Amandeep Singh, Edwin Nguyen та ін. "Ibrutinib in Combination with Venetoclax Decreases Mitochondrial Bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α Signaling Pathway in CLL". Blood 134, Supplement_1 (2019): 1282. http://dx.doi.org/10.1182/blood-2019-127562.

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Objective: Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia in adults. Altered mitochondrial metabolism has been shown to be involved in the pathogenesis of CLL. Ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK), and venetoclax, an inhibitor of B-cell lymphoma 2 (Bcl-2) protein are approved therapies for CLL. The adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) signaling axis senses the metabolic demands of cells and regulates mitochondrial function. Silent information regulato

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Ciccarone, Fabio, Luca Di Leo, Giacomo Lazzarino, et al. "Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response." British Journal of Cancer 122, no. 2 (2019): 182–93. http://dx.doi.org/10.1038/s41416-019-0641-0.

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Abstract Background Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific enzymes or defective aerobic metabolism is associated with tumour growth. Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far. Methods Biochemical assays coupled with molecular biology, in silico, and cellular tools were applied to circumstantiate the impact of ACO2 in the breast cancer cell line MCF-7 metabolism. Fluorescence lifetime imaging microscopy (FLIM) of NAD

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Hards, Kiel, Gregory Cook, and Lars J. C. Jeuken. "Bacterial respiration keeps amazing us in the 21st century." Biochemist 43, no. 6 (2021): 22–26. http://dx.doi.org/10.1042/bio_2021_185.

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The last two decades have seen some remarkable discoveries in bacterial bioenergetics. In this article, we highlight how important societal issues such as antimicrobial resistance and sustainable fuel production have led to a renewed focus on the bioenergetics of bacteria, which is only beginning to show us how much we have left to learn. Advances in technology, particularly through biophysics, have further contributed to a rapid progress in our understanding of the respiratory chain complexes in bacteria. Blue-sky research has seamlessly merged with solutions to societal problems and we stand

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Lewis, Robert. "Bioenergetics In Search Of A Secure Self." Clinical Journal of the International Institute for Bioenergetic Analysis 17, no. 1 (2007): 135–64. http://dx.doi.org/10.30820/0743-4804-2007-17-135.

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This paper, based on my personal experience and more recently available biographical and autobiographical sources, is an attempt to reevaluate classical (Lowenian) bioenergetic analysis from a perspective based on recent research from the attachment paradigm. Specifically, it explores the use of the body, its energy and sexuality as substitutes for a secure relationship with a caregiver.

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Kelvin E Vulla, Beatrice Francis, Richard S Komba, and Zabron Janes. "Polyphosphates: Essential bioenergetic reservoirs and their role as critical nutrient depleters in biological system." International Journal of Life Science Research Archive 8, no. 1 (2025): 019–32. https://doi.org/10.53771/ijlsra.2025.8.1.0024.

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Polyphosphates are linear polymers of inorganic phosphate that play a pivotal role in cellular bioenergetics and metabolism across a wide range of organisms. This review article explores the multifaceted functions of polyphosphates as essential bioenergetic reservoirs, highlighting their ability to store and release energy, thereby facilitating various biochemical processes. We discuss the synthesis and degradation pathways of polyphosphates, their influence on ATP metabolism, and their regulatory roles in cellular signaling and stress responses. Additionally, we examine how polyphosphates act

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Resneck-Sannes, Helen. "Neuroscience, Attachment and Love." Clinical Journal of the International Institute for Bioenergetic Analysis 22, no. 1 (2012): 9–28. http://dx.doi.org/10.30820/0743-4804-2012-22-9.

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Findings from the neuroscientific research with its emphasis on attachment are presented. The focus of this research is primarily on the body in the brain and there is little interest or discussion of what goes on below the head. This neuroscientific view of attachment is contrasted with the attachment theories of Harry Harlow and Alexander Lowen, both based on the relationship between the mother and infant’s bodies. Other forms of somatic therapies are compared with bioenergetics, pointing out a few of the ideas they have borrowed from the theory and practice of bioenergetics, but have not tr

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Moncada, S. "A2. Nitric oxide and bioenergetics: Physiology and pathophysiology." Nitric Oxide 17 (2007): 9. http://dx.doi.org/10.1016/j.niox.2007.09.007.

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Stirling, Elizabeth, Ethan Willey-Shelkey, Adam Wilson, et al. "206 An immune-competent tumor organoid platform to test novel immune checkpoint combinations targeting the receptor CD47 in triple negative breast cancer." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A222. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0206.

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BackgroundImmune checkpoint blockade therapy targeting PD-L1 has recently been approved for metastatic triple negative breast cancer (TNBC) patients. However, a 7% response rate calls for better models and strategies to stimulate TN-tumor immunogenicity to increase patient response. Overexpression of the receptor CD47 impairs innate and adaptive tumor immunosurveillance when engaged to its counter receptor SIRPα or ligand thrombospondin-1. Co-expression of CD47 and PD-L1 is implicated with disease progression in TNBC patients. We examined through murine models and tumor organoid platforms whet

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Oliveira, Wellington de Almeida, Renata Emmanuele Assunção Santos, Gizele Santiago de Moura Silva, Kelli Nogueira Ferraz-Pereira, Ana Lisa do Vale Gomes, and Mariana Pinheiro Fernandes. "Mitochondrial bioenergetics and oxidative balance in in vitro arbovirus infection models: a systematic review." Research, Society and Development 11, no. 16 (2022): e266111637749. http://dx.doi.org/10.33448/rsd-v11i16.37749.

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Introduction: Viral infections affect oxidative metabolism and may have repercussions on mitochondrial alterations, compromising cellular homeostasis. Objectives: To assess mitochondrial bioenergetics and oxidative balance in in vitro arbovirus infection models. Methods: The review was written in accordance with the PRISMA and submitted to the Open Science FrameWork platform with DOI 10.17605 / OSF.IO / 8ZFSW. Were used the Descriptors/MeSH (Arbovirus, Arboviruses, Arbovirus infections, Mitochondria, Oxidative stress and Reactive oxygen species) was carried out on the platforms: PubMed, SCOPUS

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Gyllenhammer, Lauren E., Sonja Entringer, Claudia Buss, and Pathik D. Wadhwa. "Developmental programming of mitochondrial biology: a conceptual framework and review." Proceedings of the Royal Society B: Biological Sciences 287, no. 1926 (2020): 20192713. http://dx.doi.org/10.1098/rspb.2019.2713.

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Research on mechanisms underlying the phenomenon of developmental programming of health and disease has focused primarily on processes that are specific to cell types, organs and phenotypes of interest. However, the observation that exposure to suboptimal or adverse developmental conditions concomitantly influences a broad range of phenotypes suggests that these exposures may additionally exert effects through cellular mechanisms that are common, or shared, across these different cell and tissue types. It is in this context that we focus on cellular bioenergetics and propose that mitochondria,

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George, Mitchell J., James Bynum, Prajeeda Nair, et al. "Platelet biomechanics, platelet bioenergetics, and applications to clinical practice and translational research." Platelets 29, no. 5 (2018): 431–39. http://dx.doi.org/10.1080/09537104.2018.1453062.

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Barger, Jennifer F., and David R. Plas. "Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis." Endocrine-Related Cancer 17, no. 4 (2010): R287—R304. http://dx.doi.org/10.1677/erc-10-0106.

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Cancer biologists' search for new chemotherapy targets is reinvigorating the study of how cancer cell metabolism determines both oncogenic potential and chemotherapeutic responses. Oncogenic metabolic programs support the bioenergetics associated with resistance to programed cell death and provide biosynthetic building blocks for cell growth and mitogenesis. Both signal transduction pathway activation and direct mutations in key metabolic enzymes can activate the metabolic programs that support cancer cell growth. Cancer-associated metabolic programs include glycolysis, glutamine oxidation, an

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Borisov, Vitaliy B., and Elena Forte. "Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics." International Journal of Molecular Sciences 22, no. 23 (2021): 12688. http://dx.doi.org/10.3390/ijms222312688.

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This review focuses on the effects of hydrogen sulfide (H2S) on the unique bioenergetic molecular machines in mitochondria and bacteria—the protein complexes of electron transport chains and associated enzymes. H2S, along with nitric oxide and carbon monoxide, belongs to the class of endogenous gaseous signaling molecules. This compound plays critical roles in physiology and pathophysiology. Enzymes implicated in H2S metabolism and physiological actions are promising targets for novel pharmaceutical agents. The biological effects of H2S are biphasic, changing from cytoprotection to cytotoxicit

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Schmitt, Fabian, and Gunter P. Eckert. "Caenorhabditis elegans as a Model for the Effects of Phytochemicals on Mitochondria and Aging." Biomolecules 12, no. 11 (2022): 1550. http://dx.doi.org/10.3390/biom12111550.

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The study of aging is an important topic in contemporary research. Considering the demographic changes and the resulting shifts towards an older population, it is of great interest to preserve youthful physiology in old age. For this endeavor, it is necessary to choose an appropriate model. One such model is the nematode Caenorhabditis elegans (C. elegans), which has a long tradition in aging research. In this review article, we explore the advantages of using the nematode model in aging research, focusing on bioenergetics and the study of secondary plant metabolites that have interesting impl

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Kozhukhar, Natalya, and Mikhail F. Alexeyev. "35 Years of TFAM Research: Old Protein, New Puzzles." Biology 12, no. 6 (2023): 823. http://dx.doi.org/10.3390/biology12060823.

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Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable

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Ijare, Omkar, David Conway, Alan Cash, David Baskin, and Kumar Pichumani. "CBMT-49. OXALOACETATE ALTERS GLUCOSE METABOLISM IN GLIOBLASTOMA: 13C ISOTOPOMER STUDY." Neuro-Oncology 21, Supplement_6 (2019): vi43—vi44. http://dx.doi.org/10.1093/neuonc/noz175.171.

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Abstract Anhydrous enol-oxaloacetate (AEO) has demonstrated the ability to enhance neuronal cell bioenergetics and activate brain mitochondrial biogenesis. Since oxaloacetate has demonstrated positive effects on brain bioenergetics in neurodegenerative diseases we have begun to investigate whether AEO may also have a positive effect on the altered cellular metabolism found in cancer cells, particularly Glioblastoma multiforme. The “Warburg effect” describes an abnormal metabolic state in cancer, distinct from normal tissue, in which energy is generated through enhanced conversion of pyruvate t

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Bittman, Kevin S. "Immune Cell Metabolic Fitness for Life." Antibodies 11, no. 2 (2022): 32. http://dx.doi.org/10.3390/antib11020032.

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Adoptive cell therapy holds great promise for treating a myriad of diseases, especially cancer. Within the last decade, immunotherapy has provided a significant leap in the successful treatment of leukemia. The research conducted throughout this period to understand the interrelationships between cancer cells and infiltrating immune cells winds up having one very common feature, bioenergetics. Cancer cells and immune cells both need ATP to perform their individual functions and cancer cells have adopted means to limit immune cell activity via changes in immune cell bioenergetics that redirect

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Roh, Tae Hoon, Ji-Hyun Lee, Seo Jin Kim, et al. "A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres." Journal of Neuro-Oncology 156, no. 1 (2021): 139–51. http://dx.doi.org/10.1007/s11060-021-03903-7.

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Ramirez-Peña, Esmeralda, James Arnold, Vinita Shivakumar, et al. "The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression." Cancers 11, no. 10 (2019): 1610. http://dx.doi.org/10.3390/cancers11101610.

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Identifying bioenergetics that facilitate the epithelial to mesenchymal transition (EMT) in breast cancer cells may uncover targets to treat incurable metastatic disease. Metastasis is the number one cause of cancer-related deaths; therefore, it is urgent to identify new treatment strategies to prevent the initiation of metastasis. To characterize the bioenergetics of EMT, we compared metabolic activities and gene expression in cells induced to differentiate into the mesenchymal state with their epithelial counterparts. We found that levels of GLS2, which encodes a glutaminase, are inversely a

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Mewa-Ngongang, Maxwell, Heinrich W. du Plessis, Seteno K. O. Ntwampe, et al. "Biological Stoichiometric Analysis during Substrate Utilization and Secondary Metabolite Production by Non-Saccharomyces Yeasts Using Grape Pomace Extract as Fermentation Medium." Fermentation 7, no. 2 (2021): 89. http://dx.doi.org/10.3390/fermentation7020089.

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The emerging interest in the search for alternatives to synthetic preservatives has led to various successful research studies exploring the use of yeasts as potential biological control agents and producers of biopreservatives. The findings that yeasts could be used as producers of biopreservatives lacked some engineering considerations regarding cost-effective process design for scale-up, although partial process optimization using renewable agro-waste has been achieved. This study investigated the biological stoichiometry and bioenergetic parameters during yeast growth and secondary metabol

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Wang, Tianyuan, Adnin Ashrafi, Pouya Modareszadeh, et al. "An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases." Cancers 13, no. 16 (2021): 4142. http://dx.doi.org/10.3390/cancers13164142.

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Heme is an essential prosthetic group in proteins and enzymes involved in oxygen utilization and metabolism. Heme also plays versatile and fascinating roles in regulating fundamental biological processes, ranging from aerobic respiration to drug metabolism. Increasing experimental and epidemiological data have shown that altered heme homeostasis accelerates the development and progression of common diseases, including various cancers, diabetes, vascular diseases, and Alzheimer’s disease. The effects of heme on the pathogenesis of these diseases may be mediated via its action on various cellula

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Khatri, Shikha, and David R. Plas. "Targeting bioenergetics to enhance cancer chemotherapy: Mitochondria SLP into apoptosis." Cancer Biology & Therapy 8, no. 17 (2009): 1659–61. http://dx.doi.org/10.4161/cbt.8.17.9456.

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Cheng, G., J. Zielonka, D. McAllister, S. Tsai, M. B. Dwinell, and B. Kalyanaraman. "Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation." British Journal of Cancer 111, no. 1 (2014): 85–93. http://dx.doi.org/10.1038/bjc.2014.272.

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Mohamed Suhaimi, Nur-Afidah, Wai Min Phyo, Hao Yun Yap, et al. "Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient–Derived Xenografts." Molecular Cancer Therapeutics 16, no. 9 (2017): 2035–44. http://dx.doi.org/10.1158/1535-7163.mct-16-0793.

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