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Dissertations / Theses on the topic 'Bioengineering'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Al-Hassan, Reingard. "Biomaterialien - Biomedizin - Bioengineering." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1169038192157-41852.

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Im Rahmen der VDB-Fortbildungsveranstaltung für Fachreferenten der Ingenieurwissenschaften, die am 8. und 9. Dezember 2005 in der SLUB Dresden stattfand, referierte Prof. Dr.-Ing. Hartmut Worch vom Institut für Werkstoffwissenschaften der TU Dresden (siehe auch SLUB-Kurier, 2006, Heft 1).

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2

Pozuelo, Ruiz Marta. "Bioengineering single-protein wires." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/462906.

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Electron Transfer (ET) is undoubtedly one of the most important processes in life. Molecularly well-defined ET pathways in complex protein ensembles play a vital role in biological processes such as cell respiration or photosynthesis. The fundamental understanding of ET processes in biology is important not only to understand such key natural processes but also to advance in the design of biomolecule/electrode interfaces for Bioelectronic applications. The development of new techniques such as scanning probe microscopies (SPM) played a key role. In particular, the electrochemical scanning tunn

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3

Bartelle, Benjamin B. "Bioengineering Novel Reporter Proteins." Thesis, New York University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3556976.

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<p> Visualization of gene expression has led to a revolution in biology over the past two decades. Primarily this visualization has occurred using fluorescent proteins, like GFP, that can be directly visualized with microscopy. Fluorescence imaging is limited by depth of penetration when applied to living mice or humans however. For this, MRI, ultrasound and other modalities are under continual development for <i>in vivo</i> applications. Ideally, every <i> in vivo</i> imaging modality would have their own reporter genes, allowing for unconstrained genetic studies of structure and function. Th

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4

Ip, Ling-yee Lyn, and 葉令怡. "Bioengineering and its applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B30425402.

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5

Trenner, Brian Robert. "Bioengineering for Land Stabilization." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253549875.

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6

GANAU, MARIO. "Bioengineering-enhanced neurosurgical solutions." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266684.

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The advancements in basic sciences and the availability of sophisticated technological aids have led over the last few years to the rise of innovative surgical strategies, the identification of better prognostic/predictive biomolecular factors, and the development of novel drugs all meant to profoundly impact the outcome of neurosurgical patients. This thesis touches upon the window of opportunity to exploit bioengineering techniques in three subspecialties of this vast discipline: neuro-oncology, radiosurgery and neuro-traumatology. After a thorough identification of some unresolved clinical

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7

Crowther, Damian C. "The bioengineering of targeted serpins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260598.

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8

Busuttil, Naudi Kurt. "Bone bioengineering for mandibular reconstruction." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2419/.

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The reconstruction of critical-size bone defects following tumour resection or bone loss due to trauma is topical today and relates to the complexity of the treatment involved and poor healing outcomes. In bone bioengineering, the current trends are to explore novel methods of repairing these defects by using various bone substitutes. Various graft materials have been used for the restoration of these defects. A graft ideally needs to promote osteogenesis, osteoinduction and osteoconduction. The aim of this investigation was to assess the histological, radiographic and mechanical properties of

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9

ANGELATS, LOBO DAVID. "DEVELOPMENT OF ALTERNATIVE BIOENGINEERING STRATEGIES." Doctoral thesis, Università degli studi di Brescia, 2022. http://hdl.handle.net/11379/560219.

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Concettualmente, la produzione additiva permette la rapida e precisa produzione delle parti complesse. La produzione additiva richiede di un disegno previo della parte da fabbricare per un software di progettazione assistita da computer (CAD, in inglese). A causa delle limitazioni del CAD software, particolarmente nelle curve, alcune delle parti stampate esige trattamenti aggiuntivi o di post lavorazione per ottenere la morfologia e la struttura desiderate. La produzione additiva e la stampa tridimensionale (3D) erano solo stabiliti nella area di ingegneria. Nell 21⁰ secolo, la idea di usare l

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10

ANGELATS, LOBO DAVID. "DEVELOPMENT OF ALTERNATIVE BIOENGINEERING STRATEGIES." Doctoral thesis, Università degli studi di Brescia, 2022. http://hdl.handle.net/11379/560196.

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Concettualmente, la produzione additiva permette la rapida e precisa produzione delle parti complesse. La produzione additiva richiede di un disegno previo della parte da fabbricare per un software di progettazione assistita da computer (CAD, in inglese). A causa delle limitazioni del CAD software, particolarmente nelle curve, alcune delle parti stampate esige trattamenti aggiuntivi o di post lavorazione per ottenere la morfologia e la struttura desiderate. La produzione additiva e la stampa tridimensionale (3D) erano solo stabiliti nella area di ingegneria. Nell 21⁰ secolo, la idea di usare l

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11

ANGELATS, LOBO DAVID. "DEVELOPMENT OF ALTERNATIVE BIOENGINEERING STRATEGIES." Doctoral thesis, Università degli studi di Brescia, 2022. http://hdl.handle.net/11379/560216.

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Concettualmente, la produzione additiva permette la rapida e precisa produzione delle parti complesse. La produzione additiva richiede di un disegno previo della parte da fabbricare per un software di progettazione assistita da computer (CAD, in inglese). A causa delle limitazioni del CAD software, particolarmente nelle curve, alcune delle parti stampate esige trattamenti aggiuntivi o di post lavorazione per ottenere la morfologia e la struttura desiderate. La produzione additiva e la stampa tridimensionale (3D) erano solo stabiliti nella area di ingegneria. Nell 21⁰ secolo, la idea di usare l

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12

Kuo, Cheng-Hwa. "Bioengineering scaffolds for cell migration assay." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707983.

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13

Forest, Fabien. "Bioengineering de greffons endothéliaux : versant cellulaire." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSES067.

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La cécité d’origine cornéenne est Ia deuxième cause de cécité dans le monde. Son traitement de choix est la kératoplastie. ll est aujourd’hui nécessaire de réfléchir à de nouvelles solutions pour remplacer la kératoplastie dans sa forme actuelle qui bien que satisfaisante, n’est pas totalement parfaite. En effet, les techniques actuelles de kératoplastie utilisent une allogreffe. Le greffon va subir chez le donneur une diminution de la densité des cellules endothéliales (CE) du greffon au fil du temps. Ce travail présente successivement les solutions abordées par le BiiGC pour produire des CE

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14

Browning, Alexander P. "Model complexity in biology and bioengineering." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/227787/1/Alexander_Browning_Thesis.pdf.

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In biology and bioengineering, mathematical and statistical analysis provides an understanding of biological systems that enables their control and manipulation. Tailoring mathematical and experimental complexity to the biological question of interest is crucial to avoid issues relating to parameter identifiability. We develop models and tools to bring new data-based insights to a range of contemporary problems in biology and bioengineering. These include data-focused stochastic models that describe complex cell interactions and decision making, incorporating biological systems into new engine

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15

Pescador, Álvarez Paula. "Colloidal and molecular assemblies for bioengineering applications." Doctoral thesis, Universitat Rovira i Virgili, 2007. http://hdl.handle.net/10803/8557.

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La técnica de recubrimiento "capa por capa' (layer-by-layer, LbL) de superficies cargadas mediante materiales con carga opuesta es una herramienta versátil para la fabricación de ensamblados moleculares e interfaces funcionales. Sus principales ventajas sobre otras metodologías, como las monocapas autoensambladas (SAM) o la técnica de Langmuir-Blodgett, son una enorme flexibilidad combinada con su gran simplicidad y bajo coste. Con instrumentación sencilla y protocolos de preparación simples, es posible ensamblar estructuras complejas y estables con un control nanométrico sobre su composición

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16

Bosch, Canals Begoña María. "A bioengineering approach for corneal endothelial regeneration." Doctoral thesis, Universitat Internacional de Catalunya, 2019. http://hdl.handle.net/10803/667398.

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Nowadays, there are approximately 10 million people worldwide with visual impairment due to corneal diseases. Currently, the main therapeutic solution is the transplant of a donor's cornea. The great majority of transplants is due to some failure in the inner layer of the cornea, which is called the corneal endothelium and this is mainly related with the inability of this layer to regenerate in vivo. However, transplants present several limitations such as the low number of healthy donors or immunological rejection by the patient. In order to overcome these problems, several researchers have

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17

Gamito, Pedro Santos Pinto. "Soil bioengineering : prototyping a new conceptual framework." Thesis, University of Salford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248897.

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18

Al-Gosaibi, A. M. "Bioengineering properties of soil stabilisers and mulches." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354534.

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19

Rebière, Alice. "Ultrashort laser bioengineering: Micropatterning of collagen fibers." Thesis, KTH, Tillämpad fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194398.

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20

Sclarsic, Sarah Mary Haiken. "A bioengineering roadmap for negative emissions technologies." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130839.

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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, February, 2021<br>Cataloged from the official PDF version of thesis.<br>Includes bibliographical references (pages 49-59).<br>Negative emissions technologies that can remove carbon dioxide from the atmosphere are a critical tool to limit global temperature rise and ocean acidification. Bioengineering capabilities have not been sufficiently assessed or utilized for the development of negative emissions technologies. Bioengineering holds the potential to improve the effic

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21

Barbosa, Joana Cristina Pacheco. "Lichenicidin: regulation, expression and bioengineering in E.coli." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/9548.

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Mestrado em Biotecnologia Molecular<br>A lichenicidina e um lantibiotico de classe II, naturalmente produzido por B. licheniformis I89. E constituida por dois peptidos denominados Blia e Blib. Este lantibiotico foi o primeiro a ser expresso completamente in vivo num hospedeiro Gram negativo (Escherichia coli). Neste trabalho, pretendeu-se avaliar o impacto da proteina LicR na biossintese da lichenicidina usando um sistema de expressao heterologa em E. coli. A estirpe de E. coli que nao contem o gene licR parece apresentar uma maior producao de lichenicidin do que a estirpe que contem todo o c

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22

Bisi, Maria Cristina <1983&gt. "Bioengineering of exercise: biomechanical and metabolic aspects." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2543/1/Bisi_MariaCristina_tesi.pdf.

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The field of research of this dissertation concerns the bioengineering of exercise, in particular the relationship between biomechanical and metabolic knowledge. This relationship can allow to evaluate exercise in many different circumstances: optimizing athlete performance, understanding and helping compensation in prosthetic patients and prescribing exercise with high caloric consumption and minimal joint loading to obese subjects. Furthermore, it can have technical application in fitness and rehabilitation machine design, predicting energy consumption and joint loads for the subjects who

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Bisi, Maria Cristina <1983&gt. "Bioengineering of exercise: biomechanical and metabolic aspects." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2543/.

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The field of research of this dissertation concerns the bioengineering of exercise, in particular the relationship between biomechanical and metabolic knowledge. This relationship can allow to evaluate exercise in many different circumstances: optimizing athlete performance, understanding and helping compensation in prosthetic patients and prescribing exercise with high caloric consumption and minimal joint loading to obese subjects. Furthermore, it can have technical application in fitness and rehabilitation machine design, predicting energy consumption and joint loads for the subjects who

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24

Schaefer, James William. "Bioengineering and reclamation to stabilize a lakeshore slope." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ40105.pdf.

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25

Tyber, Jeffrey Alan. "Mechanical behavior of materials for reconstructive bioengineering applications." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p1430186.

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26

Clark, J. E. "Principles of bioengineering with reference to East Nepal." Thesis, Cranfield University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526482.

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27

Lorenz, Astrid. "Bioengineering transgenic plants to detoxify nitroaromatic explosive compounds." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441030.

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28

Lassalle, Astrid. "Ultrashort Laser Bioengineering: Micropatterning of Cellularized Collagen Fibers." Thesis, KTH, Tillämpad fysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-208072.

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29

Waterhouse, Anna. "Bioengineering a coronary stent with covalently immobilised tropoelastin." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28916.

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This thesis describes the characterisation and development of covalently immobilised recombinant human tropoelastin (TE) on a plasma-activated coating (PAC) as a potential stent coating for the treatment of coronary artery disease. A biomimetic approach was used to create a biocompatible coating with an immobilised human protein to enhance biointegration of an implanted stent. A coating that enhanced endothelialisation while displaying low tbrombogenicity was developed and characterised in vitro and in vivo. Covalent binding of TE to PAC was verified using ELISA and radiolabelled TE. Modulati

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30

CROCE, STEFANIA. "Mesenchymal stromal cells on bioscaffold for liver bioengineering." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1329186.

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Tissue bioengineering is the creation of functional tissues or whole organs by manufacturing body parts ex vivo, seeding cells on a supporting scaffold. The final goal of organ bioengineering is the use of the bioengineered organs as ‘replacement parts’ for the human body. The need for bioengineered livers is significant: currently, the only effective treatment for end-stage liver failure is orthotopic liver transplantation. However, the shortage of organ donors results every year in the death of many patients in the waiting list. Moreover, the advantage of this technology is the use of autolo

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31

Groleau, Nicolas. "Model-based scientific discovery--a study in space bioengineering." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/12902.

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32

Jeewandara, Thamarasee M. "Bioengineering Stents for Proactive Biocompatibility: From Biomaterials to Stents." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14974.

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The thesis describes methods to characterize modified biomaterial surfaces in vitro, and investigate its short term implications at the artery interface in vivo. Plasma activated coating (PAC) technology has been previously deposited on a stainless steel biomaterial (316LSS), investigated in the stent form in vivo. Initial histopathology characterizations conducted with resin-artery-stents evaluate artery-stent interface interactions in vivo. The 7 day pilot study was followed by detailed material characterization and biofunctionalization on a modified cobalt chromium metal alloy L605, for the

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Mummery, Gavin Thomas. "Developing a high-resolution bioengineering model for slope stability analysis." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435426.

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Sharma, Vaibhav. "Bioengineering of a novel fibrinalginate scaffold for tissue engineering applications." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10037661/.

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Over the last few decades, developing reconstructed dermis with the potential of replacing the injured dermis is highly explored. Even though a range of dermal scaffolds are available commercially (Integra® and Matriderm®), none have shown the potential to regenerate injured skin similar to normal skin. Commercially available dermal scaffolds have a range of limitations such as wound contraction, scar formation and poor integration with the host tissue. Designing three dimensional scaffolds using tissue engineering approaches involves optimising the architectural design of the scaffold to prom

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Viray, Christina Marie. "Developing Innovative Bioengineering Platforms to Recapitulate Cell Microenvironments In Vitro." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24955.

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Bioprinting has recently emerged as a promising fabrication technique for developing 3D biologically functional, tissue-like constructs. Amongst the various bioprinting approaches, stereolithography (SLA) offers the highest feature resolutions that can be utilised to mimic the complex hierarchical architectures found within human tissues and organs. While significant efforts have been directed towards harnessing digital light processing (DLP) SLA techniques, less attention has been given towards the use of laser-based SLA and the corresponding development of cytocompatible bioresins for such s

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Thiabgoh, Ongard. "Novel Magneto-LC resonance Sensors for Industrial and Bioengineering Applications." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7650.

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The scientific studies associated with material engineering and device miniaturization are the core concepts for future technology innovation. The exploring and tailoring of material properties of amorphous magnetic microwires, recently, have revealed remarkable high sensitive magnetic field sensitivity down to the picoTesla regime at room temperature. This superior magnetometer is highly promising for active sensing and real-time monitoring building block for modern industrial devices and healthcare applications. The low-field, high sensitivity regime of the GMI response over a wide frequency

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37

Giupponi, L. "BOTANICAL CONTRIBUTIONS TO IMPROVE THE ASSESSMENT OF SOIL BIOENGINEERING WORKS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/488066.

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The research described in this PhD dissertation was conducted during the period 2014-2016 at the Centre of Applied Studies for the Sustainable Management and Protection of Mountain Areas (Ge.S.Di.Mont. - University of Milan) in Edolo (BS) with the objective of devising botanical methods/tools that could be useful for improving the evaluation of soil bioengineering works in mountain areas. This research has led to the formulation of two floristic-vegetational indices: the Ecological Index of Maturity (EIM) and the Index of Ecological Success (IES). These indices were applied to three study area

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Aebi, Dominic. "Bioengineering studies for improved fermentative hydrogen production and microbial electricity generation." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107894.

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To supplement the non-renewable energy sources which are heavily relied-upon today, much research is being done to develop environmentally-friendly "Green Energy" and biologically-based "Bio Energy".The potential of microbial fuel cells (MFCs) as one of these next-generation energy sources was the first of two main aspects of this Master's research. Their suitability as a waste valorization by means of bioelectricity generation was investigated. The study employed a 50ml, single-chamber MFC system to compare substrate removal and electrical production using both minimal media and waste media d

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Phairatana, Tonghathai. "Bioengineering of novel carbon-based biosensors for real-time biomedical use." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58345.

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The aim of this thesis was to develop novel carbon-based biosensors and sensors for real-time metabolite and drug detection, to provide the next generation of medical devices which can give clinicians relevant chemical information in real-time at the patient bedside. An autocalibration system was developed using LabSmith programmable components to give precise fluid delivery and excellent temporal control of multiple liquid streams. This enables a 5-point calibration to be carried out using two solutions in 12 minutes. Systems using chitosan, poly(ethylene glycol)diglycidyl ether hydrogel, ele

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Jorge, João Manuel Pereira. "Bioengineering of Lactococcus lactis through modulation of its major glucose transporter." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/9061.

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Mak, Wing Cheung. "The applications of layer-by-layer technology in bioengineering and bioanalytics /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202004%20MAK.

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Merino, Araneda German Enrique. "Bioengineering requirements for the intensive culture of California halibut (Paralichthys californicus) /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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Barnes, Devon. "In vitro bioengineering applications of melt electrowritten and hydrogel composite scaffolds." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212352/1/Devon_Barnes_Thesis.pdf.

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Two-dimensional cell cultures provide an inaccurate representation of how cells develop and are affected by disease and injury. Scaffold-based tissue engineering techniques that combine novel biomaterials and printing methods could assist in the design of more physiologically relevant, three-dimensional experimental tissue models. This thesis investigated the application of carbohydrate glass as a sacrificial material toward producing perfusable hydrogel devices using melt electrowriting, the development and optimisation of a three-dimensional bioengineered bone marrow microenvironment, and a

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TRAVERSARI, GABRIELE. "Analysis of multi-phase systems relevant to bioengineering and materials science." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/312667.

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In the thesis the focus is on the analysis of two multiphase systems related to biomedical engineering and materials science. The first part of the thesis is related to the long-term preservation of human Mesenchymal Stem Cells (hMSCs) from Umbilical Cord Blood (UCB) by means of cryopreservation, i.e. freezing the bio-specimens to cryogenic temperature, and drypreservation, i.e. air-drying at room temperature and atmospheric pressure. First, the peculiar osmotic behavior of hMSCs from UCB is analyzed by developing a novel mathematical model. Then, the addition and removal phases of a permeant

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Nguyen, Vina Le. "Structure-Property Relations of the Exoskeleton of the Ironclad Beetle (Zopherus Nodulosus Haldemani)." Thesis, Mississippi State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10642091.

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<p> In this study, structure-property relationships in the ironclad beetle (Zopherus nodulosus haldemani) exoskeleton are quantified to develop novel bio-inspired impact resistance technologies. The hierarchical structure of this exoskeleton was observed at various length scales for both the ironclad beetle pronotum and elytron. The exocuticle and endocuticle layers provide the bulk of the structural integrity and consist of chitin-fiber planes arranged in a Bouligand structure. The pronotum consists of a layered structure, while elytron consists of an extra layer with “tunnel-like&rdquo

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Wei, Chun-Shu. "Towards Brain Decoding for Real-World Drowsiness Detection." Thesis, University of California, San Diego, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10641645.

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<p> A brain-computer interface (BCI) allows human to communicate with a computer by thoughts. Recent advances in brain decoding have shown the capability of BCIs in monitoring physiological and cognitive state of the brain, including drowsiness. Since drowsy driving has been an urgent issue in vehicle safety that causes numerous deaths and injuries, BCIs based on non-invasive electroencephalogram (EEG) are developed to monitor drivers’ drowsiness continuously and instantaneously. Nonetheless, on the pathway of transitioning laboratory-oriented BCI into real-world applications, there are

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Middleton, Devon. "ACQUISITION, PROCESSING, AND ANALYSIS OF DIFFUSION TENSOR IMAGING AND ATROPHY MRI IN THE INJURED PEDIATRIC SPINAL CORD." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/470546.

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Bioengineering<br>Ph.D.<br>Spinal cord injury has the potential to be debilitating, particularly in the pediatric population. Identification of the exact injury level can be difficult from conventional structural Magnetic Resonance Imaging (MRI) scans, and younger children often have difficulty in participating in the clinical examinations that define neurologic damage. Because of limitations of existing clinical examinations and conventional imaging, more advanced quantitative imaging techniques are important for improvement in diagnostic and prognostic evaluation of spinal cord injury. A qua

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Pollard, David. "Histological Evaluation of the Effects of Diabetes on Renal Vasculature." Thesis, Clemson University, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13422945.

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<p> Diabetes mellitus currently affects 8.3% of the world’s population, roughly 387 million people as of 2014, with numbers rising steadily. Diabetes is a major risk factor for vascular pathology, affecting the vascular wall at the cellular and extracellular level. The field of tissue engineering has proven to have great potential in treating cardiovascular disease and kidney failure. In order to develop tissue-engineered replacements resistant to the alterations induced by a diabetic environment, the modifications of the native tissues are important to be elucidated. </p><p> Cardiovas

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Khormaee, Sariah. "Optimizing siRNA Efficacy through Alteration in the Target Cell-Adhesion Substrate Interaction." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/59.

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Abstract:

Short interfering RNA (siRNA) is a class of nucleotide drugs with a profound potential to improve patient health through its ability to silence the expression of specific genes at the post-transcriptional level. However, the clinical application of siRNA therapeutics remains hindered by a lack of efficient delivery systems that deposit siRNA into the cytoplasm of cells, a step necessary for siRNA’s silencing effect. Much research has focused on the development of siRNA delivery agents to overcome this challenge. There are no standard pre-clinical models for testing of siRNA delivery agents, an

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Fang, Shinong. "THE PREPARATION AND CHARACTERIZATION OF PRO-APOPTOTIC PEPTIDE ALA-VAL-PRO-ILE AND ITS DERIVATIVES." Master's thesis, Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/490963.

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Abstract:

Bioengineering<br>M.S.<br>The tetra-peptide sequence alanine-valine-proline-isoleucine (AVPI) is derived from a known inhibitor of apoptosis inhibitor proteins (IAPs) called Smac (second mitochondria-derived activator of caspases). Ala-Val-Pro-Ile can be further utilized as an anti-cancer agent by inhibiting the activities of apoptosis inhibitors so caspases can trigger apoptosis of cancer cells. AVPI, however, has poorly cell-penetration property thus limiting its ability to be utilized as a therapeutic agent for cancer treatments. We conjugated the AVPI molecule to a newly developed cell-pen

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