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Dissertations / Theses on the topic 'Bioflavonoids'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Smith, Adam John. "Modulating the Pharmacokinetics of Bioflavonoids." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4226.

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One of the largest obstacles in drug development is to overcome solubility and bioavailability problems. Preformulation strategies such as nanoparticle formation are often employed but sometimes create new issues and are limited in their effectiveness and applications. Since the majority of drugs are marketed and sold as solid forms, drug delivery systems are not always desirable. This is where solid-state chemistry becomes important. Traditional solid-state chemistry approaches are often successful but are sometimes too restrictive and cannot be applied to certain compounds. Cocrystals h

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2

Allers, NJ, L. Hay, PJ Schutte, ML Steinmann, Plooy S. du, and LH Bohmer. "Long-term effects of a low dosage of grape seed proanthocyanidin extract on blood pressure in spontaneously hypertensive rats." South African Journal of Science, 2008. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000779.

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Most studies on the antihypertensive effects of bioflavonoids have reported short-term effects (within 7 weeks) at high concentrations (40–100 mg kg–1 day–1). The present study by contrast has investigated long-term effects of low concentrations of bioflavonoids on arterial blood pressure and left ventricular performance in spontaneously hypertensive rats (SHR). Spontaneously hypertensive rats were divided into a treated (n = 16) and a control (n = 16) group. The treated group received daily a grape seed proanthocyanidin extract (GSPE) at a concentration of 4mg kg–1day–1over six months. Arteri

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3

Chen, Rui. "Effects of bioflavonoids on cultured human retinal pigment epithelial cells." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206176.

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The thesis describes the effects of various plant flavonoids (curcumin, epigallocatechin-3-gallate [EGCG], luteolin, apigenin, myricetin, quercetin, and cyanidin) on the physiological properties and viability of cultured human retinal pigment epithelial (RPE) cells. It is described that, with the exception of EGCG, all flavonoids tested decrease dose-dependently the RPE cell proliferation, migration, and secretion of VEGF. Luteolin, apigenin, myricetin, and quercetin decreased the viability of RPE cells at higher concentrations, by triggering cellular necrosis. Curcumin decreased the viability

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4

Chinnam, Naga babu. "Inhibition of Escherichia coli ATP Synthase Using Bioflavonoids." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1298.

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ATP synthase is the fundamental means of the cellular energy production in all organisms. Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by being a molecular target for several inhibitors. Bioflavonoids are a class of plant secondary metabolites known to exhibit antioxidants, chemopreventive, and chemotherapeutic properties. Their actual mode of action is not clear; however, some bioflavonoid are known to block the action of enzymes and othe

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5

Lal, Priya Kumari. "Maternal prenatal consumption of bioflavonoids and phenolic acids and risk of childhood brain cancer." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1080569687.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 274 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: J. Schwartzbaum, School of Public Health. Includes bibliographical references (p. 171-203).

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6

Chen, Rui [Verfasser], and Wolfgang [Gutachter] Nörenberg. "Effects of bioflavonoids on cultured human retinal pigment epithelial cells / Rui Chen ; Gutachter: Wolfgang Nörenberg." Leipzig : Universitätsbibliothek Leipzig, 2016. http://d-nb.info/1240482736/34.

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7

Kim, Sea H. "Reconstituted HDL containing apolipoprotein E3 is a potential "nanovehicle" for transport and targeted delivery of bioflavonoids." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1527329.

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<p> The objective of this study is to develop a “nanovehicle” to transport resveratrol in the plasma and to targeted intracellular sites. Resveratrol is a bioflavonoid possessing a variety of biological activities. We incorporated resveratrol into reconstituted high-density lipoproteins (rHDL), which are water-soluble lipid/protein complexes. rHDL was prepared using apolipoprotein E3 (apoE3) N-terminal domain and phospholipids. The role of apoE3 NT domain is to mediate cellular uptake of lipoproteins via the low-density lipoprotein receptor (LDLr). Biochemical, biophysical and func

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8

Hayashi, Adam. "Effects of Daily Oral Injections of Quercetin on Implanted Colon-25 Tumor Growth in Balb-C Mice." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2525/.

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The effects of three oral dosages (0.4 mg, 0.8 mg, and 1.6 mg) of quercetin on Colon-25 tumors implanted in Balb-c mice were studied. The data in this study show that: (1) certain dosages of quercetin in alcohol solutions, reduces the weight, and size of implanted Colon-25 tumors in Balb-c mice, (2) these same dosages of quercetin all produce a profound neutrophilia combined with a significant lymphopenia at day 20 post-implantation, and (3) there was relatively little evidence of histological changes in the quercetin-treated tumor section which would indicate that the action(s) of quercetin i

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9

Петренко, О. А. "Антидисбіотична профілактика експериментальних гастропатій". Thesis, ДП "Український науково-дослідний інститут медицини транспорту МОЗ України", 2021. https://essuir.sumdu.edu.ua/handle/123456789/85340.

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Дисертаційну роботу присвячено дослідженню ролі ендогенної мікробіоти в розвитку гастропатій різної етіології, тобто обгрунтуванню дисбіотичного механізму патогенеза цих захворювань. На підставі експериментальних досліджень було вперше показано, що при дії етіологічних чинників в слизовій оболонці шлунка щурів завжди збільшується рівень біохімічного маркера запалення. Вперше показано, що розвиток гастропатій за механізмом дисбіозу, судячи по збільшенню його ступеню, знижують імунний захист слизової оболонки. Вперше показано, що експериментальна терапія гепатогенної гастропатії (після введення

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10

Castro, Fabrício Faleiros de [UNESP]. "Fitogênicos ou mono e diglicerídeos associados com ácidos orgânicos em dietas para leitões recém-desmamados." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/126416.

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Made available in DSpace on 2015-08-20T17:09:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-23. Added 1 bitstream(s) on 2015-08-20T17:26:32Z : No. of bitstreams: 1 000843210.pdf: 473237 bytes, checksum: 6bdb449fdfa3ecafefb424569cad3adf (MD5)<br>Objetivou-se avaliar os efeitos da utilização de fitogênicos (óleos essenciais e bioflavonoides) ou mono e diglicerídeos associados com ácidos orgânicos nas dietas de leitões, dos 21 aos 63 dias de idade, sobre desempenho, incidência de diarreia, taxa de passagem da digesta, características microbiológicas e morfofisiológicas do trato ga

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11

Alsabban, Hajer. "Assessing the efficacy of a bioflavonoid-based mouth rinse in reducing oral malodor related to removable orthodontic appliances in comparison to chlorhexidine." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62703.

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Halitosis is an unpleasant breath odor; it affects roughly 30-50% of the population. The major compounds that contribute to halitosis that originates from the mouth, typically referred to as oral malodor, are volatile sulfur compounds (VSCs), which are produced by a variety of microorganisms. It has been shown that orthodontic patients with acrylic appliances complain of oral malodor. The source of the odor is in part due to the nature of the appliance, which retains microorganisms that are not removed by mechanical cleaning so typically the addition of an antimicrobial agent, such as Chlorhex

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12

Osorio, Durango Edison Javier. "Búsqueda de sustancias bioactivas a partir de dos especies de la flora colombiana: alcaloides de "Phaedranassa dubia" (Amaryllidaceae) y biflavonoides de "Garcinia madruno" (Clusiaceae)." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/2618.

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El objetivo del presente trabajo ha sido la búsqueda de sustancias bioactivas en dos especies de la flora colombiana. Se pretendió aislar y caracterizar los metabolitos secundarios sintetizados por <i>Phaedranassa dubia</i> (Amaryllidaceae) y <i>Garcinia madruno</i> (Clusiaceae), además de estudiar la actividad antiprotozoaria <i>in vitro</i> y de evaluar la actividad antioxidante de los metabolitos aislados. El trabajo fitoquímico realizado con <i>Phaedranassa dubia</i> ha permitido el aislamiento de un nuevo alcaloide de tipo <i>Amaryllidaceae</i>, fedranamina, cuya estructura se ha establec

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13

Marcarini, Juliana Cristina [UNESP]. "Estudo do flavonóide rutina na citotoxicidade e análise de biomarcadores gênicos e bioquímicos de estresse genotóxico e oxidativo em cultura de células." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/100521.

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Made available in DSpace on 2014-06-11T19:30:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-05-20Bitstream added on 2014-06-13T18:41:10Z : No. of bitstreams: 1 marcarini_jc_dr_rcla_parcial.pdf: 265800 bytes, checksum: c6fbdf9127d68f8975699df1a232d5e7 (MD5) Bitstreams deleted on 2015-06-25T13:00:57Z: marcarini_jc_dr_rcla_parcial.pdf,. Added 1 bitstream(s) on 2015-06-25T13:03:19Z : No. of bitstreams: 1 000728824_20161231.pdf: 225457 bytes, checksum: 79edd21e91fa8d3d9aa45c8fb9480f5f (MD5) Bitstreams deleted on 2017-01-02T15:03:49Z: 000728824_20161231.pdf,. Added 1 bitstream(s) on

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14

Chen, Rui. "Effects of bioflavonoids on cultured human retinal pigment epithelial cells." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A14819.

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The thesis describes the effects of various plant flavonoids (curcumin, epigallocatechin-3-gallate [EGCG], luteolin, apigenin, myricetin, quercetin, and cyanidin) on the physiological properties and viability of cultured human retinal pigment epithelial (RPE) cells. It is described that, with the exception of EGCG, all flavonoids tested decrease dose-dependently the RPE cell proliferation, migration, and secretion of VEGF. Luteolin, apigenin, myricetin, and quercetin decreased the viability of RPE cells at higher concentrations, by triggering cellular necrosis. Curcumin decreased the viability

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15

"Protection of okadaic acid-induced tau hyperphosphorylation by bioflavonoids in neuroblastoma cells." 2008. http://library.cuhk.edu.hk/record=b5893426.

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Pan, Tak Yin.<br>Thesis submitted in: November 2007.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references.<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.i<br>Abstract (English) --- p.ii<br>Abstract (Chinese) --- p.iv<br>Content --- p.v<br>Abbreviations --- p.x<br>List of Figures --- p.xi<br>List of Tables --- p.xii<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1.1 --- Alzheimer's Disease --- p.1<br>Chapter 1.1.1 --- Cholinergic hypothesis --- p.2<br>Chapter 1.1.2 --- p-amyloid hypothesis --- p.2<br>Chapter 1.

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16

Malone, Sara Rae. "The bioavailability of 90MX cranberry powder and quercetin when administered to horses." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17519.

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17

Gupta, A. "Assessment of citrus bioflavonoid and phytosterol supplements for dipeptidyl peptidase-4 inhibitory activity." Thesis, 2020. https://eprints.utas.edu.au/35880/1/Gupta_whole_thesis.pdf.

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Background Diabetes is a chronic condition characterised by abnormal hyperglycaemic activity with type 2 diabetes accounting for 90% of diabetes cases. Prediabetes is a condition in which blood sugar levels are higher than normal, but do not fall in the range of diabetes. People with prediabetes suffer from either impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) and are at high risk of developing diabetes or cardiovascular related diseases. There is an increasing prevalence of type 2 diabetes worldwide which is causing significant morbidity, with statistics obtained from th

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18

Mendes, Luís Filipe Figueiredo. "Metabolomics study of flavonoid-induced metabolic reprogramming in human macrophages." Master's thesis, 2018. http://hdl.handle.net/10773/25305.

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The ability of macrophages to change between pro-inflammatory (M1-like) and anti-inflammatory (M2-like) phenotypes makes their modulation an attractive therapeutic strategy to mitigate excessive and/or chronic inflammation. Bioflavonoids are natural compounds with well documented anti-inflammatory activity. However, little is known about their molecular and metabolic effects on human macrophages. In this thesis, NMR metabolomics has been used to assess how different bioflavonoids (Quercetin, Naringenin and Naringin) modulate the metabolism of human macrophages, with a view to better understand

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19

Thomas, Howard, D. P. Dowling, and Maria G. Katsikogianni. "Bioflavonoid coated materials." 2014. http://hdl.handle.net/10454/11555.

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no<br>Polymeric materials are described which have a bioflavonoid coating, the bioflavonoid content of the coating comprising at least naringin and neohesperidin. The use of such coated polymeric materials is also described as well as the process for making the coated polymeric materials.

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20

Novotná, Martina. "Kapilární elektroforéza v analýze bioflavonoidů a fytofarmak." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-291043.

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A method based on capilllary zone electrophoresis (CZE) with UV detection was developed for simultaneous separation and determination of bioflavonoids hesperidin and diosmin. The analysis was performed in a fused silica capillary with effective lenght 60 cm and 50 μm I.D. UV detection was used at 207 nm. The optimum separation conditions were found out in this work. Samples were loaded hydrodynamically at a pressure of 50 mbar for 20 s. The background electrolyte consisted of 10 mM phosphate, 40 mM borate buffer with 10% MeOH, 15 mM -CD (pH* 8,0) at 25 řC. The separation voltage was +20 kV. M

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21

Moon, Young Jin. "Pharmacokinetics and pharmacodynamics of the bioflavonoid biochanin A." 2007. http://proquest.umi.com/pqdweb?did=1481671151&sid=3&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on Oct. 15, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Morris, Marilyn E. Includes bibliographical references.

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22

Marshall, Maria Jozefa. "The supplementation of a bioflavonoid product as an alternative for synthetic vitamin A and E in broiler diets." Diss., 2016. http://hdl.handle.net/2263/57258.

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Biological systems are subject to oxidative stress and free radical attack. Free radicals and reactive oxygen species are formed as by-products of aerobic metabolism and redox reactions that occur naturally in living organisms. When there is an imbalance in their production and elimination they can cause extensive tissue damage. In order to protect itself from damage of ROS and free radicals the body has antioxidant defence systems in place which consists of enzymatic- and non enzymatic systems. Vitamin A and Vitamin E are two antioxidants included in the diet that form part of these defence

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23

Brandt, Ina [Verfasser]. "Untersuchung der Proliferationshemmung von Brustkrebszellen durch das Bioflavonoid Quercetin in Kombination mit dem mTOR-Inhibitor Everolimus (RAD001) / vorgelegt von Ina Brandt." 2011. http://d-nb.info/1011014955/34.

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24

Marathe, Sandhya. "Modulation Of Bacterial Pathogenesis By Curcumin." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2335.

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Foodborne diseases are one among the diseases with high morbidity and mortality rate. The concern is raised with the emergence of pathogenic strains that are resistant to the available set of antibiotics. Conventional regimens fail to treat the infections caused by these pathogens prolonging the sickness leading to increased morbidity and mortality. The situation can get further complicated with the dietary intake of the host. Of late it has been understood that the dietary flavonoids play an important role in regulating the immune system. Curcumin, a pigment from turmeric, is one among such b

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25

Marathe, Sandhya. "Modulation Of Bacterial Pathogenesis By Curcumin." Thesis, 2012. http://hdl.handle.net/2005/2335.

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Foodborne diseases are one among the diseases with high morbidity and mortality rate. The concern is raised with the emergence of pathogenic strains that are resistant to the available set of antibiotics. Conventional regimens fail to treat the infections caused by these pathogens prolonging the sickness leading to increased morbidity and mortality. The situation can get further complicated with the dietary intake of the host. Of late it has been understood that the dietary flavonoids play an important role in regulating the immune system. Curcumin, a pigment from turmeric, is one among such b

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26

Oerding, Matthias [Verfasser]. "Einflüsse von Hyperthermie in Kombination mit Chemotherapie und dem Bioflavonoid Quercetin auf die Zellüberlebensraten und die Hitzeschockprotein-Expression der humanen Ewingsarkom-Zelllinien SK-ES-1 und RD-ES : Zellkinetikmessungen mit dem XTT-Essay und Nachweis der Proteinexpression mittels Western-Blot-Analyse / vorgelegt von Matthias Oerding." 2005. http://d-nb.info/978343417/34.

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