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Dissertations / Theses on the topic 'Biofluids'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Chen, Liwei. "Dense Matrices for Biofluids Applications." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-theses/579.

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In this report, we focus on Biofluids problems, specifically the Stokes Equation. The method of regularized Stokeslets can be derived from bound- ary integral equations derived from the Lorentz reciprocal identity. When body forces are known, this is a direct numerical approximation of an in- tegral, resulting in a summation to determine the fluid velocity. In certain cases, which this report is focused on, we know the velocity and want to determine the forces on a structure immersed in a fluid. This results in a lin- ear system Af = u, where A is a square dense matrix. We study different meth

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2

Akers, Walter John. "Flourescent molecular rotors as mechanosensors in biofluids." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4114.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 19, 2007) Vita. Includes bibliographical references.

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Sequeira, Suzanne Simone. "'1 NMR spectroscopic investigations into the metabolism and biochemical effects of model drugs and enzyme inducers in the rat." Thesis, Birkbeck (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342211.

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4

Untereiner, Valérie. "La spectroscopie infrarouge des biofluides dans le domaine biomédical : de l'analyse des facteurs pré-analytiques et analytiques aux applications cliniques." Thesis, Reims, 2020. http://www.theses.fr/2020REIMM205.

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Dans le domaine biomédical, l’identification de nouveaux marqueurs diagnostiques et pronostiques est un enjeu majeur pour améliorer la prise en charge des patients. A côté des techniques telles que la protéomique, la génomique, la transcriptomique, les techniques biophotoniques appliquées aux biofluides représentent une approche innovante pour mettre au point un nouvel outil diagnostique. L’objectif de ce travail a été d’analyser certains processus pré-analytiques et analytiques permettant la translation de la spectroscopie infrarouge à haut débit vers la clinique. Une revue bibliographique ap

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5

Kelly, Mark Joseph. "Metal ion equilibria in biofluids - copper and rheumatoid arthritis." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/9584.

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Includes bibliographies.<br>A computer model of blood plasma has been used to evaluate the factors affecting the ability of a ligand to increase the low molecular weight copper pool in vivo. The justification for using this speciation approach is based on the assumption that the low molecular weight copper complexes are important in the reduction of the inflammation associated with rheumatoid arthritis. Based on the results of the simulation, two novel ligands, 3,6,9, 12-tetra-azatetradecanedioic acid (dtda) and 3,6,9,-triazaundecanedioic acid (dtda) have been synthesised using a three step ro

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6

Harder, Ulrike. "Amino acid analysis in biofluids using LC-MS/MS." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-166180.

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Klinische Studien zeigen, dass die Zusammensetzung von zirkulierenden, freien AS im Blut, ein Marker für monogene und multigenetische Krankheiten ist. Die Analyse von hohen Probandenzahlen in klinischen Studien wird oftmals durch aufwendige und lange Probenaufarbeitungsschritte begrenzt. Im Rahmen der Metabolomics Plattform, die im Dr. von Haunerschen Kinderspitals etabliert wurde, wurde eine Hochdurchsatzmethode entwickelt, die eine selektive, sensitive, präzise und robuste Quantifizierung von 22 AS aus kleinen Probenvolumina ermöglicht. Im Laufe der Zeit konnten noch weitere Aminosäuren zur

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Walne, Amanda Jayne. "Pyridinium crosslinks in serum and other biofluids in health and disease." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363047.

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8

Teague, Claire Rachel. "NMR spectroscopic and chemometric approaches to investigate metabolic variation in biofluids." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414749.

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Guha, Indra Neil. "Exploring the diagnostic tools for the assessment of liver fibrosis using biofluids." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443044.

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10

Swales, John. "Mass spectrometry methods for profiling xenobiotic distribution in biofluids and whole tissues." Thesis, Sheffield Hallam University, 2018. http://shura.shu.ac.uk/22414/.

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Historically, studies of drug biodistribution are traditionally carried out in the later stages of pre-clinical pharmaceutical research and development (R&D) using radio-labelled techniques. Such studies are often slow, expensive and unselective, meaning resulting data can be complicated to deconvolute and too late in the development pipeline to change the medicine under investigation. Mass spectrometry imaging (MSI) has the potential to provide an unlabelled, multiplex method of mapping and quantifying molecular distributions within tissues at a much earlier stage in the R&D timeline, informi

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Dalirirad, Shima. "Developing Aptamer-based Biosensor for Onsite Detection of Stress Biomarkers in Noninvasive Biofluids." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595849507754655.

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12

Rocha, Cláudia Manuela Mesquita da. "Metabolic signature of lung cancer: a metabolomic study of human tissues and biofluids." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/13957.

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Doutoramento em Química<br>This thesis reports the application of metabolomics to human tissues and biofluids (blood plasma and urine) to unveil the metabolic signature of primary lung cancer. In Chapter 1, a brief introduction on lung cancer epidemiology and pathogenesis, together with a review of the main metabolic dysregulations known to be associated with cancer, is presented. The metabolomics approach is also described, addressing the analytical and statistical methods employed, as well as the current state of the art on its application to clinical lung cancer studies. Chapter 2 provides

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Parry, K. W. "Fuel cell based instrumentation for ethanol determination in alcoholic beverages, fermentations and biofluids." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380194.

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14

Jobard, Elodie. "Identification of Systemic Markers of Cancer from NMR Metabolomic Investigation of Human Biofluids." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0878.

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La métabolomique propose une approche basée sur l’étude d’une réponse métabolique globale et dynamique d’un organisme à des stimuli biologiques ou à des mutations génétiques et ainsi constitue un outil de recherche translationnel à fort potentiel en oncologie. Nous avons appliqué l’approche métabonomique par RMN à haut champ à l’analyse d’échantillons sanguins issus d’études cliniques coordonnées par le Centre Léon Bérard et pour la cohorte prospective E3N (Etude Epidémiologique auprès de femmes de la MGEN) dans le but d’identifier de marqueurs systémiques du cancer à partir de fluides biologi

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PALMAS, FRANCESCO. "Versatility and Clinical Applications of Metabolomics: Tissues and Biofluids Investigation for Pathological Clustering." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255984.

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Metabolomics is the discipline that comprehensively and simultaneously profile the metabolome within a sample or organism. Investigating the downstream processes from gene expression and protein synthesis to the metabolic network, metabolomics may be of pivotal importance for the design of new screening methodology, for the identification of novel biomarkers and for the study of diseases at molecular and biochemical level. To this end, the versatility of metabolomic strategy was exploited for the investigation of diverse clinical conditions and different phenotypes regarding pregnancy, n

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Heller, Anne. "Spektroskopische Untersuchungen zur Komplexbildung von Cm(III) und Eu(III) mit organischen Modellliganden sowie ihrer chemischen Bindungsform in menschlichem Urin (in vitro)." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-70475.

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Dreiwertige Actinide (An(III)) und Lanthanide (Ln(III)) stellen im Falle ihrer Inkorporation eine ernste Gefahr für die Gesundheit des Menschen dar. An(III) sind künstlich erzeugte, stark radioaktive Elemente, die insbesondere bei der nuklearen Energiegewinnung in Kernkraftwerken entstehen. Durch Störfälle oder nicht fachgerechte Lagerung radioaktiven Abfalls können sie in die Umwelt und die Nahrungskette des Menschen gelangen. Ln(III) sind hingegen nicht radioaktive Elemente, die natürlicherweise vorkommen und für vielfältige Anwendungen in Technik und Medizin abgebaut werden. Folglich kann d

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Bamba, Mamadou. "Development and application of novel computational intelligence techniques to the multivariate analysis of metabolomics biofluids datasets." Thesis, De Montfort University, 2017. http://hdl.handle.net/2086/16407.

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The present decades have witnessed major advances in the development and applications of Computational Intelligence Techniques (CITs), which are commonly associated with metabolomics and omics analyses related to diseases diagnosis. This includes, amongst others, research work performed on Niemann-Pick class 1 and 2 diseases (NPC1 and NPC2 respectively), the severest form of which may involve liver dysfunction. Some of the main reasons for the high frequency of CITs use in metabolomics studies are also related to the development of techniques to detect major discriminatory metabolite variables

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Khaled, Abdul Rahim Assaad Mr. "Non-isothermal characterization of squeezed thin films in the presence of biofluids and suspended ultrafine particles." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1071085983.

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Lind, Anne-Li. "Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-326180.

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Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. In this thesis, consisting of five studies, pain patient biofluids were analyzed with modern proteomic methods to identify biomarker candidates that can be used to improve our understanding of the pathophysiology chronic pain and lead to more effective treatments. Paper I is a proof of concept study, where

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Khaled, Abdul Rahim Assaad. "Non-isothermal characterization of squeezed thin films in the presence of biofluids and suspended ultrafine particles." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1071085983.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 172 p.; also includes graphics. Includes bibliographical references (p. 168-172).

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DALLA, MARTA SILVIA. "Development of nanostructured substrates for quantification of anticancer drugs in biofluids with Surface Enhanced Raman Scattering (SERS)." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908137.

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To date, therapeutic drug monitoring (TDM), that is the quantification of anticancer drugs in biofluids of oncological patients, is expensive and time consuming. Such a quantitative determination is crucial for a successful chemotherapic treatment due to the high interpatient variability of the anticancer drugs levels in biofluids. A frequent TDM turns out to be necessary to limit as far as possible the heavy side-effects of the treatment. Thus, the development of a new Point Of Care (POC) tool for a faster and less expensive TDM is highly desirable. Surface Enhanced Raman Scattering (SERS) is

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Pitts, Katie Lynn. "Rheological and Velocity Profile Measurements of Blood in Microflow Using Micro-particle Image Velocimetry." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24038.

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Microhemodynamics is the study of blood flow in small vessels, usually on the order of 50 to 100 µm. The in vitro study of blood flow in small channels is analogous to the in vivo study of the microcirculation. At this scale the Reynolds and Womersly numbers are significantly less than 1 and the viscous stress and pressure gradient are the main determinant of flow. Blood is a non-homogeneous, non-Newtonian fluid and this complex composition and behavior has a greater impact at the microscale. A key parameter is the shear stress at the wall, which is involved in many processes such as platel

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Fellman, Batya A. (Batya Ayala). "A study of a flapping flag in viscoelastic fluids and its implications for micro-scale swimming in biofluids." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45795.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.<br>Includes bibliographical references (leaf 37).<br>Biological cells and organisms employ a different method of propulsion when in viscous, viscolelastic fluids rather than Newtonian fluids. By studying the dynamics of a flag under a flow of a viscoelastic fluid, we hope to better understand the swimming dynamics in these biological fluids. A slender polysiloxane rod was placed in a rotating annulus filled with a cetyl pyridnium chloride micellar solution and also with a xanthan gum solution. Flapping

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Souza, Dyego Monteiro de. "Estudo do comportamento tribológico de aços tratados termoquimicamente lubrificados com biofluidos e óleo mineral." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-07112016-143049/.

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Tratamentos termoquímicos são processos utilizados pela indústria em componentes de sistemas mecânicos com o intuito de melhorar as suas propriedades superficiais, em especial o desempenho em desgaste. Esses sistemas são utilizados em conjunto com lubrificantes em máquinas e equipamentos dos mais variados tipos. Normalmente os lubrificantes mais usados em função do seu bom desempenho, são de base mineral. Entretanto, há vários estudos propondo o uso de lubrificantes de base vegetal mas pouco se conhece da interação da superfície com esses biofluidos. Sendo assim é importante se identificar com

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Hussain, Shawn. "Développement de méthodes biophotoniques appliquées aux biofluides pour le diagnostic rapide et non-invasif du cancer." Thesis, Reims, 2019. http://www.theses.fr/2019REIMP201.

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La spectroscopie vibrationnelle englobe les techniques optiques spécifiques de la spectroscopie infrarouge à transformée de Fourier (IRTF) et Raman (RS). Ces techniques sondent les vibrations moléculaires de l’échantillon lorsque la lumière interagit avec celui-ci, ce qui représente des ‘empreintes moléculaires’ de la composition chimique globale. Les deux techniques sont très prometteuses pour le diagnostic en santé, notamment dans le cadre des ‘biopsies liquides’, en particulier les biofluides. Cette étude a porté sur le développement des méthodologies bio-spectroscopiques pour l’analyse bio

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Du, Fuying, and 杜富滢. "Microchip-capillary electrophoresis devices with dual-electrode detectors for determination of polyphenols, amino acids andmetabolites in wine and biofluids." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48521693.

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The electrochemical detector provides a promising detection mode for capillary electrophoresis (CE) due to its excellent sensitivity, good portability, high selectivity, easy miniaturization, low capital and running cost. To widen its scope for determining trace analytes in complex samples, three dual-electrode detectors were fabricated to enable the determination of electro-inactive analytes, to assess co-eluted peaks and to give a large enhancement of the detection sensitivity by modifying electrode surface using multi-walled carbon nanotubes (MWNTs). To determine trace non-electroactive

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Grimm, Laura Marie [Verfasser], and S. [Akademischer Betreuer] Bräse. "Capturing and detection of small biomolecules by supramolecular approaches in water and biofluids / Laura Marie Grimm ; Betreuer: S. Bräse." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/1238147984/34.

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Devenport, Neil A. "Novel methods for the rapid and selective analysis of biological samples using hyphenated ion mobility-mass spectrometry with ambient ionization." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/14287.

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The increased use of mass spectrometry in the clinical setting has led to a demand for high sample throughput. Developments such as ultra high performance liquid chromatography and the ambient ionization techniques enable high sample throughput by reducing chromatographic run times or by removing the requirement for sample preparation and fractionation prior to analysis. This thesis assesses the reproducibility and robustness of these high throughput techniques for the analysis of clinical and pharmaceutical samples by ion mobility-mass spectrometry. The rapid quantitative analysis of the urin

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Monteiro, Anita-Ann. "Detection of exosomal mirna from different volumes of biofluids as biomarkers for the diagnosis of sepsis : Future diagnostics of sepsis." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17592.

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Sepsis, a life-threatening condition which results from a dysregulation of host response to infection and leads to multiple organ dysfunction, is a cause for great concern. The current gold standard of detection – Blood culturing – is a highly time-consuming process and so, research has proposed the use of biomarkers. Current biomarkers, C-reactive protein and Procalcitonin, though good indicators, individually show certain limitations with respect to the specificity and sensitivity. Hence, as a step forward from singleplex biomarkers, the development of a multi-marker panel was suggested. For

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Zhang, Xiaolu. "NANOPARTICLE BEHAVIOR IN BIOLOGICAL GELS AND BIOFLUIDS: THE IMPACT OF INTERACTIONS WITH CHARGED BIOGELS AND THE FORMATION OF PROTEIN CORONAS ON NANOPARTICLES." UKnowledge, 2015. http://uknowledge.uky.edu/chemistry_etds/57.

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With the rapid growth of nanotechnology, situations where nanomaterials will interact with biological systems will unquestionably grow. Therefore, it is increasingly understood that interactions between nanomaterials and biological environments will play an essential role in nanomedicine. Biological polymer networks, including mucus and the extracellular matrix, serve as a filter for the exchange of molecules and nanoparticles. Such polymer networks are complex and heterogeneous hydrogel environments that regulate transport processes through finely tuned particle-network interactions. In chapt

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Harder, Ulrike [Verfasser], and Berthold [Akademischer Betreuer] Koletzko. "Amino acid analysis in biofluids using LC-MS/MS : method development, validation and application in clinical research and dairy science / Ulrike Harder. Betreuer: Berthold Koletzko." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1048361772/34.

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Tang, Jianhua. "Development of a Novel Gradient Chromatofocusing Tandem Mass Spectrometry Technique for the Determination of Cationic Compounds in Biofluids; Identification of Caspase 3 Cleavage Sites of NHE-1 by High Performance Liquid Chromatography-Mass Spectrometry." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1247344073.

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Tang, Jianhua. "Development of a novel gradient chromatofocusing tandem mass spectometry technique for the determination of cationic compounds in biofluids identification of caspace 3 cleavage sites of nhe-1 by high performance liquid chromatography- mass spectrometry /." Cleveland, Ohio : Cleveland State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1247344073.

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Thesis (Ph. D.)--Cleveland State University, 2009.<br>Abstract. Title from PDF t.p. (viewed July 29, 2009). Includes bibliographical references (p. 105). Available online via the OhioLINK ETD Center and also available in print.

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Pendelton, Alice Mae. "Biofluid lubrication for artificial joints." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3205.

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Bruckner, Michael. "Biofluid Mechanics Of Embryo Transfer." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10159.

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Cette thèse porte sur l'étude du comportement hydrodynamique d'un embryon lors de la procédure de transfert suivant la fécondation in-vitro. Un couple sur six fait l'expérience de problèmes d'infertilité. Aujourd'hui 5 millions de nourrissons sont nés depuis la première fécondation in-vitro en 1978. En 2009, 1.5 millions de cycles de Procréation Médicalement Assistée étaient débutés, donnant ainsi naissance à350 000 nourrissons de par le monde. Le nombre de cycle est en constante augmentation de 5 à 10 % par an et le nombre de cycle de PMA pourrait être proche de 4 millions à l'horizon 2020. B

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Dickens, Alex. "Biofluid analysis to differentiate brain disease." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572775.

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It has been demonstrated that by using 1H NMR spectroscopy in combination with multivariate statistical modelling (PLS) it is possible, using urine samples obtained from rats, to distinguish between different types of CNS lesions. Against this background this thesis will explore whether the combination of 1H NMR and PLS modelling on biofluids can be used q-1eientify biomarkers in .. - different neurological diseases and in clinically relevant animal models of neurologic disease. The results in this thesis demonstrate that it is possible to separate sets of animals at different stages of diseas

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Bevan, Rhodri L. T. "A locally conservative Galerkin approach for subject-specific biofluid dynamics." Thesis, Swansea University, 2010. https://cronfa.swan.ac.uk/Record/cronfa42314.

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In this thesis, a parallel solver was developed for the modelling of blood flow through a number of patient-specific geometries. A locally conservative Galerkin (LCG) spatial discretisation was applied along with an artificial compressibility and characteristic based split (CBS) scheme to solve the 3D incompressible Navier-Stokes equations. The Spalart-Allmaras one equation turbulence model was also optionally employed. The solver was constructed using FORTRAN and the Message Passing Interface (MPI). Parallel testing demonstrated linear or better than linear speedup on hybrid patient-specific

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Costa, Pedro Miguel Rocha Cardoso Nunes da. "Análise do perfil proteico de biofluidos em pacientes com hemofilia A." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11762.

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Mestrado em Bioquímica - Bioquímica Clínica<br>A hemofilia A é um distúrbio hemorrágico congénito caracterizado pelo comprometimento da cascata de coagulação devido à ausência ou deficiência da atividade do fator VIII que é provocada por uma mutação presente no respetivo gene. As características clínicas e as complicações que acompanham os pacientes hemofílicos ao longo da sua vida, como hemorragias espontâneas ou artropatia resultante de hemartroses recorrentes, exigem o recurso frequente a serviços de saúde. Contudo, nem sempre se verifica uma correlação entre a severidade da doença,

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Richardson, Jordan Frederick. "Biofluid investigations using mass spectrometry : detection and characterisation of analgesic drug metabolites." Thesis, Keele University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545752.

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Honan, Mallory Cate. "Examination Of Bovine Rumen Fluid And Milk Fat Globule Membrane Proteome Dynamics." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1164.

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Proteomic technology has been increasingly incorporated into agricultural research, as characterization of proteomes can provide valuable information for potential biomarkers of health and physiological status of an animal. As dairy cattle are a dominant production animal in the USA, their biofluids such as milk, blood, urine, and rumen fluid have been examined by proteomic analysis. The research outlined herein was performed to further characterize the dynamics of specific proteomes and relate them to dairy cattle physiology. The first experiment evaluated the diurnal dynamicity of the rumen

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Lyons, Alexander. "The effect of isokinectic exercise on biofluid matrices as measured by 1H NMR spectroscopy." Thesis, University of East London, 2015. http://roar.uel.ac.uk/4772/.

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The biochemical basis of muscle function during stress imposed by isokinetic exercise has mainly focused on measuring muscle proteins (CK and myoglobin) and lactate present in the blood plasma, whereas the range of low-molecular weight metabolites during muscular stress has received limited attention. This study investigated the effect of concentric isokinetic exercise of the knee extensor and flexor muscles (functional to standing, walking and running), at 80% and 40%MVC intensities of equal workloads, on saliva, urine and blood serum matrices. A hypothesis-free approach was employed to mathe

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Postigo, Matheus Pereira. "Uso de ressonância magnética nuclear na análise metabolômica de biofluidos de animais tratados com ivermectina." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-24072012-164610/.

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A pesquisa bioquímica no campo da Metabolômica/Metabonômica tem se intensificado consideravelmente nos últimos anos, por sua capacidade de adquirir uma grande quantidade de informação a respeito do comportamento de um organismo através de seu metabolismo. Para isso, frequentemente faz uso da aplicação das mais diversas técnicas analíticas, como a Ressonância Magnética Nuclear. A Ivermectina é um fármaco de amplo uso no Brasil, dada a sua eficiência no controle de verminoses e pragas em gado (e humanos) e está aqui inserida no contexto metabolômico/metabonômico dadas as inúmeras violações ocorr

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ESPOSITO, ALESSANDRO. "Sviluppo e caratterizzazione di substrati SERS label-free per analisi di biofluidi e applicazioni biomediche." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3030740.

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Surface Enhanced Raman spectroscopy is a powerful analytical technique, in which are combined high sensitivity and chemical species recognition, which are provided by the surface signal enhancement and the vibrational fingerprinting of the Raman spectroscopy, respectively. Thus, the inelastic scattering (or Raman scattering) of the light is used to capture so-called Raman active vibrations in presence of an external source of light. On the base of this phenomenon, unique vibration can allow identifying with high selectivity a tremendous number of chemical structures. But, Raman scattering is d

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Alves, Levy Anderson César. "Estudo do metaboloma de biofluidos em pacientes pediátricos nefropatas e sua associação com a doença periodontal." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23132/tde-04112016-104007/.

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Metabolômica é a técnica que analisa quantitativamente metabólitos endógenos e exógenos de baixa massa molecular encontrados em biofluidos e tecidos. Estas pequenas moléculas representativas encontradas em um sistema biológico abrangem carboidratos, ácidos graxos, nucleotídeos, aminoácidos entre outras classes de compostos. Alguns estudos têm mostrado a importância da manutenção da saúde bucal para pacientes com doença renal crônica (DRC). DRC, um problema mundial de saúde pública, pode ser definida em função da presença de danos renais ou de uma taxa de filtração glomerular < 60 mL/min por 1.

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Levene, Clare. "Advanced Raman, SERS, and ROA studies of biomedical and pharmaceutical compounds in solution." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/advanced-raman-sers-and-roa-studies-of-biomedical-and-pharmaceutical-compounds-in-solution(1c05f618-b1c2-4663-870a-3d51b32dad7b).html.

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The primary purpose of this study was to investigate the combination of experimental and computational methods in the search for reproducible colloidal surface-enhanced Raman scattering of pharmaceutical compounds. In the search for optimal experimental conditions for colloidal surface-enhance Raman scattering, the amphipathic β-blocker propranolol was used as the target molecule. Fractional factorial designs of experiments were performed and a multiobjective evolutionary algorithm was used to find acceptable solutions, from the results, that were Pareto ranked. The multiobjective evolutionary

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Comerford, Andrew Peter. "Computational Models of Endothelial and Nucleotide Function." Thesis, University of Canterbury. Mechanical Engineering, 2007. http://hdl.handle.net/10092/1178.

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Atherogenesis is the leading cause of death in the developed world, and is putting considerable monetary pressure on health systems the world over. Although the risk factors are well understood, unfortunately, the initiation and development of this disease still remains relatively poorly understood, but it is becoming increasingly identifiable as a dysfunction of the endothelial cells that line the walls of arteries. The prevailing haemodynamic environment plays an important role in the focal nature of atherosclerosis to very specific regions of the human vasculature. Disturbed haemodynamics l

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Simmers, Phillip Charles. "Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535634635926094.

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Afonso, Maria do Rosário da Silva. "A física de alguns biofluídos : proposta de abordagem da sub-unidade "Mecânica de Fluídos"." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/2573.

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Mestrado em Ensino de Física e Química<br>Neste trabalho é proposta uma abordagem no ensino da Mecânica de Fluidos inovadora, tendo como objectivo primordial cativar o maior interesse dos alunos para o estudo da Física. Recorrendo a fenómenos físicos que ocorrem no corpo humano, é possível ensinar uma vasta gama de conteúdos de Física através da experimentação e da sua interpretação no contexto de Ciência, Tecnologia e Sociedade. Neste trabalho, são apresentadas algumas actividades experimentais de fácil execução na sala de aula e que possam contribuir para uma melhor eficácia no ensino/aprend

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Damon, Deidre Erin. "Development of Functionalized Paper-Based Sample Collection and Direct Mass Spectrometry Analysis Platforms." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1550776934984565.

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Biglino, Giovanni. "Experimental study of the mechanics of the intra-aortic balloon." Thesis, Brunel University, 2010. http://bura.brunel.ac.uk/handle/2438/4510.

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This thesis deals with the mechanics of the Intra-Aortic Balloon Pump (IABP), the most widely used temporary cardiac assist device, whose beneficial action is based on the principle of counterpulsation. The investigation is carried out in vitro in increasingly more realistic setups, including a mock circulatory system with physiological distribution of peripheral resistance and compliance in which IABP counterpulsation was simulated. Pressure and flow measurements show the effect of variables such as intra-luminal pressure, angle and aortic compliance on balloon hemodynamics. These data are co

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