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1

Callejas, Miriam Martinez. "Understanding bioidentical hormones and their effect on quality of life." Journal of Aesthetic Nursing 8, no. 10 (2019): 467–71. http://dx.doi.org/10.12968/joan.2019.8.10.467.

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It is important to understand the functions of the body's hormones and the options available to make the right choices for use in treating the symptoms of menopause. Bioidentical hormones are compounds that have exactly the same chemical and molecular structure as endogenous human hormones. In contrast, non-bioidentical—or synthetic—hormones are structurally dissimilar from endogenous hormones. Although it has been available for years, bioidentical compounded hormone therapy has gained popularity only recently. This article highlights the main functions of these hormones and how hormone imbala
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2

Callejas, Alison Culkin Miriam Martinez. "Understanding bioidentical hormones and their effect on quality of life." Journal of Prescribing Practice 2, no. 1 (2020): 18–22. http://dx.doi.org/10.12968/jprp.2020.2.1.18.

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It is important to understand the functions of the body's hormones and the options available to make the right choices for use in treating the symptoms of menopause. Bioidentical hormones are compounds that have exactly the same chemical and molecular structure as endogenous human hormones. In contrast, non-bioidentical—or synthetic—hormones are structurally dissimilar from endogenous hormones. Although it has been available for years, bioidentical compounded hormone therapy has gained popularity only recently. This article highlights the main functions of these hormones and how hormone imbala
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3

Sites, Cynthia K. "Bioidentical Hormones for Menopausal Therapy." Women's Health 4, no. 2 (2008): 163–71. http://dx.doi.org/10.2217/17455057.4.2.163.

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'Bioidentical hormones' is a term created by the lay media to refer to chemicals derived from plants that are modified to be structurally identical to endogenous human hormones. These compounds include estradiol, estrone, estriol, progesterone, testosterone and dehydroepiandrosterone when prescribed for menopausal women. Patients assume bioidentical hormones are natural and safer than synthetic hormones with regard to the risk of developing breast cancer and other diseases, but there is little evidence to support this belief. Proponents of this therapy also support the use of salivary hormone
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4

Richman, Susan. "Bioidentical hormones." American Journal of Obstetrics and Gynecology 203, no. 6 (2010): e7. http://dx.doi.org/10.1016/j.ajog.2010.08.008.

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5

Martins, Vera, Nick Legroux, Monica Lascar, and Marion Gluck. "Compounded bioidentical HRT improves quality of life and reduces menopausal symptoms." Journal of Prescribing Practice 2, no. 7 (2020): 384–90. http://dx.doi.org/10.12968/jprp.2020.2.7.384.

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Bioidentical hormone replacement therapy, a form of hormone balancing and treatment that uses hormones identical to the ones naturally produced by the body, is an effective and well-tolerated method of hormone replacement therapy. The Marion Gluck Clinic conducted a small-scale study to assess the effectiveness of compounded bioidentical hormone replacement therapy treatment protocols and their impact on the quality of life of women experiencing symptoms of the menopause. Quality of life was assessed by completing the Greene Climacteric Scale questionnaire before and after bioidentical hormone
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6

Chervenak, Judi. "Bioidentical hormones for maturing women." Maturitas 64, no. 2 (2009): 86–89. http://dx.doi.org/10.1016/j.maturitas.2009.08.002.

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7

Jaffe, Robert B., Leslie Salomone, and Richard J. Santen. "Bioidentical (Natural) Hormones and Menopause." Journal of Clinical Endocrinology & Metabolism 90, no. 11 (2005): 0. http://dx.doi.org/10.1210/jcem.90.11.9994.

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8

Quilligan, Edward J., Moon H. Kim, and Thomas J. Garite. "Live webinar on bioidentical hormones." American Journal of Obstetrics and Gynecology 203, no. 6 (2010): 519. http://dx.doi.org/10.1016/j.ajog.2010.08.006.

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9

FRIEDEN, JOYCE. "FDA Cracks Down on Bioidentical Hormones." Clinical Endocrinology News 3, no. 2 (2008): 1–2. http://dx.doi.org/10.1016/s1558-0164(08)70044-0.

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10

Fugh-Berman, Adriane, and Jenna Bythrow. "Bioidentical Hormones for Menopausal Hormone Therapy: Variation on a Theme." Journal of General Internal Medicine 22, no. 7 (2007): 1030–34. http://dx.doi.org/10.1007/s11606-007-0141-4.

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11

Pinter, Bojana. "The mis(t)ery of bioidentical hormones." Maturitas 81, no. 1 (2015): 158. http://dx.doi.org/10.1016/j.maturitas.2015.02.175.

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12

Panay, Nick, and Anna Fenton. "Bioidentical hormones: what is all the hype about?" Climacteric 13, no. 1 (2010): 1–3. http://dx.doi.org/10.3109/13697130903550250.

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13

Huntley, A. L. "Compounded or confused? Bioidentical hormones and menopausal health." Menopause International 17, no. 1 (2011): 16–18. http://dx.doi.org/10.1258/mi.2011.011009.

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14

Perkins, Meghan S., Renate Louw-du Toit, and Donita Africander. "Hormone therapy and breast cancer: emerging steroid receptor mechanisms." Journal of Molecular Endocrinology 61, no. 4 (2018): R133—R160. http://dx.doi.org/10.1530/jme-18-0094.

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Although hormone therapy is widely used by millions of women to relieve symptoms of menopause, it has been associated with several side effects such as coronary heart disease, stroke and increased invasive breast cancer risk. These side effects have caused many women to seek alternatives to conventional hormone therapy, including the controversial custom-compounded bioidentical hormone therapy suggested to not increase breast cancer risk. Historically, estrogens and the estrogen receptor were considered the principal factors promoting breast cancer development and progression; however, a role
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15

L’Hermite, M. "Bioidentical menopausal hormone therapy: registered hormones (non-oral estradiol ± progesterone) are optimal." Climacteric 20, no. 4 (2017): 331–38. http://dx.doi.org/10.1080/13697137.2017.1291607.

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16

Bhavnani, Bhagu R., and Frank Z. Stanczyk. "Misconception and Concerns about Bioidentical Hormones Used for Custom-Compounded Hormone Therapy." Journal of Clinical Endocrinology & Metabolism 97, no. 3 (2012): 756–59. http://dx.doi.org/10.1210/jc.2011-2492.

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17

Holtorf, Kent. "The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy?" Postgraduate Medicine 121, no. 1 (2009): 73–85. http://dx.doi.org/10.3810/pgm.2009.01.1949.

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18

Miller, Howard. "Response to “The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy?”." Postgraduate Medicine 121, no. 4 (2009): 172. http://dx.doi.org/10.3810/pgm.2009.07.2042.

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19

Sood, Richa, Roger A. Warndahl, Darrell R. Schroeder, et al. "Bioidentical compounded hormones: A pharmacokinetic evaluation in a randomized clinical trial." Maturitas 74, no. 4 (2013): 375–82. http://dx.doi.org/10.1016/j.maturitas.2013.01.010.

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20

Santoro, Nanette, Glenn D. Braunstein, Cherie L. Butts, Kathryn A. Martin, Michael McDermott, and JoAnn V. Pinkerton. "Compounded Bioidentical Hormones in Endocrinology Practice: An Endocrine Society Scientific Statement." Journal of Clinical Endocrinology & Metabolism 101, no. 4 (2016): 1318–43. http://dx.doi.org/10.1210/jc.2016-1271.

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21

Sood, R., L. Shuster, R. Smith, A. Vincent, and A. Jatoi. "Counseling Postmenopausal Women about Bioidentical Hormones: Ten Discussion Points for Practicing Physicians." Journal of the American Board of Family Medicine 24, no. 2 (2011): 202–10. http://dx.doi.org/10.3122/jabfm.2011.02.100194.

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22

&NA;. ""Bioidentical hormones" should be considered to have the same risks as traditional HRT,." Reactions Weekly &NA;, no. 1023 (2004): 3. http://dx.doi.org/10.2165/00128415-200410230-00006.

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23

Tsushima, Yumiko, and Alexandra Mikhael. "Bioidentical Hormone Replacement Therapy at a Hormone Clinic Causing Significant Virilization in a Post-Menopausal Women." Journal of the Endocrine Society 5, Supplement_1 (2021): A778. http://dx.doi.org/10.1210/jendso/bvab048.1583.

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Abstract Introduction: Bioidentical hormones (BH) are compounds that have the exact chemical and molecular composition as hormones produced in our bodies. The term typically refers to testosterone, progesterone, and androgens. Compounding pharmacies market these products as being individually tailored, safer, and more effective than modified hormones synthesized under FDA supervision. These compounded products are not subject to FDA approval for dose, purity, safety, or efficacy, which poses a risk to patients. Our case highlights the dangers of unmonitored BH replacement therapy (BHRT) use an
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24

Bosarge, Penelope M., and Sarah Freeman. "Bioidentical Hormones, Compounding, and Evidence-Based Medicine: What Women's Health Practitioners Need to Know." Journal for Nurse Practitioners 5, no. 6 (2009): 421–27. http://dx.doi.org/10.1016/j.nurpra.2009.03.011.

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25

Tatarchuk, T. F., Z. M. Dubossarska, V. I. Pyrohova, et al. "On the use of sex steroids in women during the COVID-19 pandemic." Reproductive Endocrinology, no. 58 (May 27, 2021): 9–16. http://dx.doi.org/10.18370/2309-4117.2021.58.9-16.

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The document was approved at an expanded meeting of the Ukrainian Society of Gynecological Endocrinology with the involvement of all board members and representatives of the Association of Obstetricians-Gynecologists of Ukraine, the Association of Pharmacologists of Ukraine, the Association of Anesthesiologists of Ukraine, as well during the Third Ukrainian School of Gynecological and Reproductive Endocrinology with international participation ISGE 19–20.03.21.The COVID-19 pandemic has significantly impacted medical practice, in terms of organizational and clinical practices, posing a number o
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26

Fishman, Jennifer R., Michael A. Flatt, and Richard A. Settersten. "Bioidentical hormones, menopausal women, and the lure of the “natural” in U.S. anti-aging medicine." Social Science & Medicine 132 (May 2015): 79–87. http://dx.doi.org/10.1016/j.socscimed.2015.02.027.

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27

Shufelt, Chrisandra L., and JoAnn E. Manson. "Menopausal Hormone Therapy and Cardiovascular Disease: The Role of Formulation, Dose, and Route of Delivery." Journal of Clinical Endocrinology & Metabolism 106, no. 5 (2021): 1245–54. http://dx.doi.org/10.1210/clinem/dgab042.

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Abstract Context This mini-review provides an overview of menopausal hormone therapy (HT) and cardiovascular disease (CVD) risk, with a focus on the role of hormone formulation, dose, and route of delivery. Methods This summary is based on authors’ knowledge in the field of menopausal HT and supplemented by a PubMed search using the terms “menopause hormone therapy,” “transdermal,” “estradiol,” “conjugated estrogens,” “bioidentical,” “cardiovascular disease,” “lipoproteins,” “glucose,” “progestogens,” “low dose.” Results Available evidence indicates that oral unopposed estrogens have a favorab
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28

Iftikhar, Salma, Lynne T. Shuster, Ruth E. Johnson, Sarah M. Jenkins, and Dietlind L. Wahner-Roedler. "Use of Bioidentical Compounded Hormones for Menopausal Concerns: Cross-Sectional Survey in an Academic Menopause Center." Journal of Women's Health 20, no. 4 (2011): 559–65. http://dx.doi.org/10.1089/jwh.2009.1915.

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29

Files, Julia A., Marcia G. Ko, and Sandhya Pruthi. "Bioidentical Hormone Therapy." Mayo Clinic Proceedings 86, no. 7 (2011): 673–80. http://dx.doi.org/10.4065/mcp.2010.0714.

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30

Richardson, Marcie K. "Bioidentical hormone therapy." Menopause 23, no. 4 (2016): 353–54. http://dx.doi.org/10.1097/gme.0000000000000629.

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31

Stuenkel, Cynthia A., and JoAnn E. Manson. "Compounded Bioidentical Hormone Therapy." JAMA Internal Medicine 177, no. 12 (2017): 1719. http://dx.doi.org/10.1001/jamainternmed.2017.5141.

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32

Pinkerton, JoAnn V., and Nanette Santoro. "Compounded bioidentical hormone therapy." Menopause 22, no. 9 (2015): 926–36. http://dx.doi.org/10.1097/gme.0000000000000420.

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33

Kaunitz, Andrew M., and Jonathan D. Kaunitz. "Compounded bioidentical hormone therapy." Menopause 22, no. 9 (2015): 919–20. http://dx.doi.org/10.1097/gme.0000000000000484.

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34

MacLennan, Alastair H., and David W. Sturdee. "The ‘bioidentical/bioequivalent’ hormone scam." Climacteric 9, no. 1 (2006): 1–3. http://dx.doi.org/10.1080/13697130500487166.

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35

Boothby, Lisa A., Paul L. Doering, and Simon Kipersztok. "Bioidentical hormone therapy: a review." Menopause 11, no. 3 (2004): 356–67. http://dx.doi.org/10.1097/01.gme.0000094356.92081.ef.

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36

Rosenthal, M. S. "Ethical problems with bioidentical hormone therapy." International Journal of Impotence Research 20, no. 1 (2007): 45–52. http://dx.doi.org/10.1038/sj.ijir.3901622.

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37

Pattimakiel, Lynn, and Holly L. Thacker. "Bioidentical hormone therapy: Clarifying the misconceptions." Cleveland Clinic Journal of Medicine 78, no. 12 (2011): 829–36. http://dx.doi.org/10.3949/ccjm.78a.10114.

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38

Dilks, Aly, and Emma Soos. "Bioidentical hormone replacement therapy: implications for practice." Journal of Aesthetic Nursing 8, no. 4 (2019): 166–71. http://dx.doi.org/10.12968/joan.2019.8.4.166.

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In recent years, there has been a cultural shift towards greater acknowledgement of the effects of menopause on women's health, wellbeing and their relationships at both work and home, and an awareness of the very acute need for these symptoms to be monitored and addressed holistically as and when they change. No longer is it accepted that women should just ‘get on with it’, or feel helpless that there are few resources available to help them. As a result, there has been an increase in interest in bio-identical hormone replacement therapy (BHRT), especially following a greater media coverage o
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39

Cicinelli, Ettore. "Bioidentical estradiol gel for hormone therapy in menopause." Expert Review of Obstetrics & Gynecology 2, no. 4 (2007): 423–30. http://dx.doi.org/10.1586/17474108.2.4.423.

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40

Newson, Louise, and Janice Rymer. "The dangers of compounded bioidentical hormone replacement therapy." British Journal of General Practice 69, no. 688 (2019): 540–41. http://dx.doi.org/10.3399/bjgp19x706169.

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41

Files, Julia A., Lisa N. Kransdorf, Marcia Ko, et al. "Bioidentical hormone therapy: An assessment of provider knowledge." Maturitas 94 (December 2016): 46–51. http://dx.doi.org/10.1016/j.maturitas.2016.08.014.

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42

Cirigliano, Michael. "Bioidentical Hormone Therapy: A Review of the Evidence." Journal of Women's Health 16, no. 5 (2007): 600–631. http://dx.doi.org/10.1089/jwh.2006.0311.

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43

Gersak, Ksenija, Miriam Z. Gersak, and Lucija Vrabic Dezman. "Overtreatment with “bioidentical” hormone replacement therapy – a case report." Maturitas 81, no. 1 (2015): 148. http://dx.doi.org/10.1016/j.maturitas.2015.02.147.

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44

Pinkerton, JoAnn V. "Think Twice Before Prescribing Custom-Compounded Bioidentical Hormone Therapy." Journal of Women's Health 23, no. 8 (2014): 631–33. http://dx.doi.org/10.1089/jwh.2014.1505.

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45

Whelan, Anne Marie, Jean-Pierre Thebeau, Tannis M. Jurgens, and Eileen Hurst. "Bioidentical hormone therapy: Nova Scotia pharmacists´ knowledge and beliefs." Pharmacy Practice (Internet) 10, no. 3 (2012): 159–67. http://dx.doi.org/10.4321/s1886-36552012000300006.

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46

Boothby, Lisa A., and Paul L. Doering. "Bioidentical hormone therapy: a panacea that lacks supportive evidence." Current Opinion in Obstetrics and Gynecology 20, no. 4 (2008): 400–407. http://dx.doi.org/10.1097/gco.0b013e3283081ae9.

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47

Pinkerton, JoAnn V. "What are the concerns about custom-compounded “bioidentical” hormone therapy?" Menopause 21, no. 12 (2014): 1298–300. http://dx.doi.org/10.1097/gme.0000000000000376.

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48

Yuksel, Nese, Laetitia Treseng, Bushra Malik, and Ubaka Ogbogu. "Promotion and marketing of bioidentical hormone therapy on the internet." Menopause 24, no. 10 (2017): 1129–35. http://dx.doi.org/10.1097/gme.0000000000000901.

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49

Pinkerton, JoAnn V. "Concerns about safety and efficacy of compounded bioidentical hormone therapy." Menopause 28, no. 8 (2021): 847–49. http://dx.doi.org/10.1097/gme.0000000000001813.

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50

Kozlov, P. V. "The Estrogen Component of Menopausal Hormone Therapy as a Preventive Strategy." Doctor.Ru 19, no. 8 (2020): 77–79. http://dx.doi.org/10.31550/1727-2378-2020-19-8-77-79.

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Objective of the Review: To discuss clinical and experimental research data, focused on some non-reproductive effects of estrogens and the role of menopausal hormone therapy (MHT) in ensuring women’s health during aging and preventing age-associated diseases. Key Points: Combination oral MHT is most effective in preventing cardiovascular diseases, metabolic syndrome, and diabetes mellitus, when initiated during the menopause transition. Individually tailored regimens containing the bioidentical estrogen 17β-estradiol and dydrogesterone, a metabolically neutral gestagen, ensure highly safe MHT.
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