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Dissertations / Theses on the topic 'Bioinformatics (technology)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Benaim, Jalfon Carlos 1966. "Analysis of the bioinformatics industry." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8882.

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Thesis (S.M.M.O.T.)--Massachusetts Institute of Technology, Sloan School of Management, Management of Technology Program, 2001.<br>Includes bibliographical references (leaf 76).<br>The rise of the commercial genomic industry and the broadening application of genomic techniques in biology and medicine together with the growing availability of DNA sequence information have created a new industry: The Bioinformatics Industry. This thesis analyzes technologies, applications market and competitors in this industry and explores potential changes to the business models that are being used today. The

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2

Fakhry, Charbel Bader. "Exploring Strategies to Integrate Disparate Bioinformatics Datasets." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7472.

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Distinct bioinformatics datasets make it challenging for bioinformatics specialists to locate the required datasets and unify their format for result extraction. The purpose of this single case study was to explore strategies to integrate distinct bioinformatics datasets. The technology acceptance model was used as the conceptual framework to understand the perceived usefulness and ease of use of integrating bioinformatics datasets. The population of this study included bioinformatics specialists of a research institution in Lebanon that has strategies to integrate distinct bioinformatics data

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Cabral, Braulio J. "Exploring Factors Influencing Information Technology Portfolio Selection Process in Government-Funded Bioinformatics Projects." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2957.

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In 2012, the National Cancer Institute's (NCI) Board of Scientific Advisors (BSA) conducted a review of the Center for Biomedical Informatics and Information Technology's (CBIIT) bioinformatics program. The BSA suggested that the lack of a formal project selection process made it difficult to determine the alignment of projects with the mission of the organization. The problem addressed by this study was that CBIIT did not have an in-depth understanding of the project selection process and the factors influencing the process. The purpose of this study was to understand the project selection pr

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4

Mooney, Marie R. "Automated Technology for Elucidating Meal Microstructures of Rat Feeding Behavior." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282579902.

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5

Mohan, Amrita. "A study of intrinsic disorder and its role in functional proteomics." [Bloomington, Ind.] : Indiana University, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3386707.

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Thesis (Ph.D.)--Indiana University, Dept. of Informatics, 2009.<br>Title from PDF t.p. (viewed on Jul 22, 2010). Source: Dissertation Abstracts International, Volume: 70-12, Section: B, page: 7298. Adviser: Predrag Radivojac.

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6

Sullivan, Matthew John. "Applying knowledge-based techniques and artificial intelligence to automated problem solving in science, technology and bioinformatics." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287431.

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7

Roach, Kenneth L. (Kenneth Lee) 1979. "A microwell array cytometry system for high throughput single cell biology and bioinformatics." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/47850.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>Includes bibliographical references (p. 91-101).<br>Recent advances in systems biology and bioinformatics have highlighted that no cell population is truly uniform and that stochastic behavior is an inherent property of many biological systems. As a result, bulk measurements can be misleading even when particular care has been taken to isolate a single cell type, and measurements averaged over multiple cell populations in a tissue can be as misleading as the average height at an elementary school. Unfortunately,

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8

Jungjit, Suwimol. "New multi-label correlation-based feature selection methods for multi-label classification and application in bioinformatics." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/58873/.

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The very large dimensionality of real world datasets is a challenging problem for classification algorithms, since often many features are redundant or irrelevant for classification. In addition, a very large number of features leads to a high computational time for classification algorithms. Feature selection methods are used to deal with the large dimensionality of data by selecting a relevant feature subset according to an evaluation criterion. The vast majority of research on feature selection involves conventional single-label classification problems, where each instance is assigned a sin

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9

Coutu-Nadeau, Charles. "Evaluating the usability of diabetes management iPad applications." Thesis, Weill Medical College of Cornell University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1526000.

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<p> <b>Background</b> Diabetes is a major cause of morbidity and mortality in the United States. In 2012, 29.1 million people were estimated to have the condition, with type 2 diabetes accounting for 95% of all cases [1]. It is currently one of the most costly conditions in the country [2] and forecasts as a heavier burden for the U.S. with the prevalence expected to significantly increase [3]. For those who live with the disease, it is possible to manage diabetes in order to prevent or delay the onset of complications [4]. However the self-management regimen is complex and impacts nearly ever

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10

Zhu, Rui. "ProteinChip SELDI-TOF MS technology to identify serum biomarkers for neuroblastoma and hepatitis B virus-induced hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36392431.

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11

Venkatesan, Aravind. "Application of Semantic Web Technology to Establish Knowledge Management and Discovery in the Life Sciences." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-24074.

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The last three decades has seen the successful development of many high-throughput technologies that have revolutionised and transformed biological research. The application of these technologies has generated large quantities of data allowing new approaches to analyze and integrate these data, which now constitute the field of Systems Biology. Systems Biology aims to enable a holistic understanding of a biological system by mapping interactions between all the biochemical components within the system. This requires integration of interdisciplinary data and knowledge to comprehensively explore

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12

Ramraj, Varun. "Exploiting whole-PDB analysis in novel bioinformatics applications." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6c59c813-2a4c-440c-940b-d334c02dd075.

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The Protein Data Bank (PDB) is the definitive electronic repository for experimentally-derived protein structures, composed mainly of those determined by X-ray crystallography. Approximately 200 new structures are added weekly to the PDB, and at the time of writing, it contains approximately 97,000 structures. This represents an expanding wealth of high-quality information but there seem to be few bioinformatics tools that consider and analyse these data as an ensemble. This thesis explores the development of three efficient, fast algorithms and software implementations to study protein struct

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13

Lunev, Alexey. "Evaluation and visualization of complexity in parameter setting in automotive industry." Thesis, Uppsala universitet, Avdelningen för beräkningsvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362711.

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Parameter setting is a process primary used to specify in what kind of vehicle an electronic control unit of each type is used. This thesis is targeted to investigate whether the current strategy to measure complexity gives user satisfactory results. The strategy consists of structure-based algorithms that are an essential part of the Complexity Analyzer - a prototype application used to evaluate the complexity. The results described in this work suggest that the currently implemented algorithms have to be properly defined and adapted to be used in terms of parameter setting. Moreover, the

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14

Zhu, Rui, and 朱睿. "ProteinChip SELDI-TOF MS technology to identify serum biomarkers for neuroblastoma and hepatitis B virus-induced hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36392431.

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15

Cartey, Luke. "Domain-specific languages for massively parallel processors." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:60f1aa3d-ba7f-4a8e-9671-d5dadb5f6e2c.

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Massively Parallel Processors provide significantly higher peak performance figures than other forms of general purpose processors. However, this comes at a cost to the developer, who needs to deal with an increasingly complicated piece of hardware, for which applications need to be tweaked and optimised to achieve high performance. Domain-specific languages have been proposed as a potential solution to this complexity problem: generating GPU applications from high-level, declarative specifications. This thesis explores two related ideas: firstly, is it practical to synthesise DSLs from high-l

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Isaksson, Magnus. "Extracting Genomic Variations using Selector Technology." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-121429.

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This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. A common feature in this thesis work is to focus the analysis on DNA regions of interest. For example, this technique can be implemented in analysing candidate regions found by whole genome studies that need validation (global to local analysis), and applications r

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Wendler, Jason Patrick. "Accessing complex genomic variation in Plasmodium falciparum natural infections." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:c9f1ea37-7005-4757-a869-7eba82406a26.

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Genetic polymorphism in Plasmodium falciparum is a considerable obstacle to malaria intervention. Parasites have repeatedly evolved to overcome every front-line antimalarial deployed throughout history, and artemisinin resistant populations are expanding in Southeast Asia. Promising vaccine candidates routinely fail when challenged by the genetic diversity of natural parasite populations, and a recent trial using a blood-stage antigen showed immunity was allele specific. Modern sequencing technologies have revolutionized our understanding of parasite genomics and population genetics by providi

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Wilman, Henry R. "Computational studies of protein helix kinks." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:21225f0e-efed-49c6-af27-5d3fe78fa731.

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Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another. Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error in the kink angle. Second the B statistic, a statistically robust method for identifying kinks. Third, Alpha Helic

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Cruz, Pulido Diana Patricia. "Comparative transcriptome profiling of human and pig intestinal epithelial cells after Deltacoronavirus infection." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587711071257247.

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Iversen, Alexandra, Ebba Nordén, Julia Bjers, Filippa Wickström, Martin Zhou, and Mohamed Hassan. "Characterisation of Potential Inhibitors of Calmodulin from Plasmodium falciparum." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170268.

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Each year countless lives are affected and about half a million people die from malaria, a disease caused by parasites originating from the Plasmodium family. The most virulent species of the parasite is Plasmodium falciparum (P. falciparum). Calmodulin (CaM) is a small, 148 amino acid long, highly preserved and essential protein in all eukaryotic cells. Previous studies have determined that CaM is important for the reproduction and invasion of P. falciparum in host cells. The primary structure of human CaM (CaMhum) and CaM from P. falciparum (CaMpf) differ in merely 16 positions, making dif

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Ramasamy, Adaikalavan. "Increasing statistical power and generalizability in genomics microarray research." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:81ccede7-a268-4c7a-9bf8-a2b68634846d.

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The high-throughput technologies developed in the last decade have revolutionized the speed of data accumulation in the life sciences. As a result we have very rich and complex data that holds great promise to solving many complex biological questions. One such technology that is very well established and widespread is DNA microarrays, which allows one to simultaneously measure the expression levels of tens of thousands of genes in a biological tissue. This thesis aims to contribute to the development of statistics that allow the end users to obtain robust and meaningful results from DNA micro

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Bhattacharya, Kanishka. "Gene x gene interactions in genome wide association studies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6cb7ab29-90df-4d70-bc2f-531f874b79d0.

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Genome wide association studies (GWAS) have revolutionized our approach to mapping genetic determinants of complex human diseases. However, even with success from recent studies, we have typically been able to explain only a fraction of the trait heritability. GWAS are typically analysed by testing for the marginal effects of single variants. Consequently, it has been suggested that gene-gene interactions might contribute to the missing heritability of complex diseases. GWAS incorporating interaction effects have not been routinely applied because of statistical and computational challenges re

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23

Harley, Linda Rosemary. "The application of a knowledge based system to micro-electrode guided neurosurgery." Thesis, Available online, Georgia Institute of Technology, 2004, 2004. http://etd.gatech.edu/theses/available/etd-02042004-131540/unrestricted/harley%5Flinda%5Fr%5F200405%5Fms.pdf.

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Thesis (M. S.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2004.<br>Dr. Michael Hunter, Committee Member ; Dr. Alexander M. Puzrin, Committee Member ; Dr. Nelson Baker, Committee Chair. Includes bibliographical references.

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24

Wang, Yuepeng. "Integrative methods for gene data analysis and knowledge discovery on the case study of KEDRI's brain gene ontology a thesis submitted to Auckland University of Technology in partial fulfilment of the requirements for the degree of Master of Computer and Information sciences, 2008 /." Click here to access this resource online, 2008. http://hdl.handle.net/10292/467.

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Junior, Moacir Alves de Campos. "Arquitetura de computação em grade aplicada a saúde: um estudo de caso em bioinformática para oncologia." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/3/3142/tde-04082009-165710/.

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Atualmente o câncer e a terceira causa de óbitos em ambos os sexos e em todas as faixas de idade. O Ministério da Saúde relata que a alta complexidade da atenção ontológica demanda alto custo financeiro e alta tecnologia. Cada vez mais, as atividades de pesquisa, prevenção, diagnóstico e tratamento do câncer são realizadas sobre um domínio multidisciplinar envolvendo medicina, química, genética, bioinformática e engenharia. Estas atividades são responsáveis por gerar e manipular grandes quantidades de dados que são geograficamente distribuídos entre as unidades de tratamento deste país. Estes

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Belgard, Tildon Grant. "Comparative neurotranscriptomics in mammals and birds." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:932c796c-d219-4df3-85cc-7d9db19d7d6b.

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In this thesis I apply new sequencing technologies and analytical methods derived from genomics and computer science to the neuroanatomy of gene expression. The first project explores characteristics of gene expression across adult neocortical layers in a representative mammal – the mouse. Amongst the thousands of genes and transcripts differentially expressed across layers, I found common functional characteristics of genes that define certain layers, candidate cases of isoform switching, and over a thousand apparent long intergenic non-coding RNA transcripts. The second project compares patt

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Gibb, Matthew Michael James. "Myocardial microstructure and its role in propagation dynamics." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:69a1a65e-9a71-422c-86e8-c347cfabf21a.

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Computational modelling and simulation, in close interaction with experiments, has provided invaluable insight into the biochemical, mechanical and electrophysiological function and dysfunction of the heart. However, limitations in imaging techniques and computing resources have precluded the analysis of tissue architecture near the cellular scale and the effect of this architecture on cardiac function. It is the wider aim of this thesis to develop a framework to characterise cardiac microstructure and to investigate the role of microstructure in cardiac propagation dynamics and arrhythmogenes

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Rosmarin, Daniel Norris. "Germline determinants of 5-fluorouracil drug toxicity and patient survival in colorectal cancer." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d5e2c306-689c-4c53-b4c3-2c1001b04ec6.

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Despite a decade of publications investigating the effect of germline polymorphisms on both toxicity related to treatment with 5-fluorouracil-based (5-FU) chemotherapy and prognosis following diagnosis with colorectal cancer (CRC), few genetic biomarkers have been identified convincingly. For 5-FU toxicity and CRC prognosis, in four results chapters, this thesis aims to validate previously-reported genetic biomarkers, identify new markers, determine the mechanistic basis of associated polymorphisms, and expand upon methods in the field. The first three results chapters investigate genetic biom

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Levin, Nadine S. "Enacting molecular complexity : data and health in the metabonomics laboratory." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3a439abb-e010-404a-af90-ffa547acc59f.

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In this dissertation, I examine how biological data practices enable researchers to interact with and enact biological life in statistical ways, and how this poses challenges to the use and integration of biological knowledge with clinical practices. Instead of considering data as a pre-existing cognitive representation of the world, I combine scholarship on the anthropology of science with scholarship from science and technology studies to consider data as a form of material practice. I consider, in other words, how data is intertwined with technologies, people, and values, such that data is

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Cominetti, Allende Ornella Cecilia. "DifFUZZY : a novel clustering algorithm for systems biology." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:072d11e5-9bf1-4c47-9593-4cdb7327feaa.

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Current studies of the highly complex pathobiology and molecular signatures of human disease require the analysis of large sets of high-throughput data, from clinical to genetic expression experiments, containing a wide range of information types. A number of computational techniques are used to analyse such high-dimensional bioinformatics data. In this thesis we focus on the development of a novel soft clustering technique, DifFUZZY, a fuzzy clustering algorithm applicable to a larger class of problems than other soft clustering approaches. This method is better at handling datasets that cont

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Hellner, Joakim. "Introducing quality assessment and efficient management of cellular thermal shift assay mass spectrometry data." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311792.

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Recent advances in molecular biology has led to the discovery of many new potential drugs. However, difficulties with in situ analysis of ligand binding prevents quick advancement in clinical trials, which stresses the need for better direct methods. A relatively new methodology, called Cellular Thermal Shift Assay (CETSA), allows for detection of ligand binding in a cells natural environment and can be used in combination with Mass Spectrometry (MS) for readout. With help from the Pelago Bioscience team, I developed a pipeline for processing of CETSA MS data and a web based system for viewing

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Reschen, Michael. "Epigenetic approaches to the study of macrophages in atherosclerosis." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:cb314b79-afc5-48a0-aa05-fe57843b8dcc.

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Coronary artery disease (CAD) is caused by atherosclerosis, a chronic inflammatory response to modified lipoproteins. A key pathophysiological event is the lipid-induced transformation of macrophages into lipid-laden foam cells and their accumulation in atherosclerotic plaques. Heritable CAD risk is associated with common genetic variants at over 40 genomic loci; the underlying causal mechanisms remain largely unknown and could affect transcriptional regulation in foam cells. Epigenetic and gene expression changes were measured in primary human macrophages before and after exposure to atheroge

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Krohn, Jonathan Jacob Pastushchyn. "Genes contributing to variation in fear-related behaviour." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:1e8e40bd-9a98-405f-9463-e9423f0a60ca.

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Anxiety and depression are highly prevalent diseases with common heritable elements, but the particular genetic mechanisms and biological pathways underlying them are poorly understood. Part of the challenge in understanding the genetic basis of these disorders is that they are polygenic and often context-dependent. In my thesis, I apply a series of modern statistical tools to ascertain some of the myriad genetic and environmental factors that underlie fear-related behaviours in nearly two thousand heterogeneous stock mice, which serve as animal models of anxiety and depression. Using a Bayesi

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Voegele, Catherine. "Development of an integrated Information Technology System for management of laboratory data and next-generation sequencing workflows within a cancer genomics research platform." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10095/document.

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L'objectif de mon travail de thèse était de développer des outils bio informatiques permettant d'améliorer la traditionnelle gestion de l'information scientifique au sein d'un grand centre de recherche et en particulier au sein d'une plateforme de génomique. Trois outils ont été développés: un cahier de laboratoire électronique, un système de gestion de l'information de laboratoire pour des applications de génomique dont le séquençage de nouvelle génération, ainsi qu'un système de gestion des échantillons pour de grandes bio-banques. Ce travail a été réalisé en étroite collaboration avec des b

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Spreco, Armin. "Epidemiological and statistical basis for detection and prediction of influenza epidemics." Doctoral thesis, Linköpings universitet, Avdelningen för samhällsmedicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136553.

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A large number of emerging infectious diseases (including influenza epidemics) has been identified during the last century. The emergence and re-emergence of infectious diseases have a negative impact on global health. Influenza epidemics alone cause between 3 and 5 million cases of severe illness annually, and between 250,000 and 500,000 deaths. In addition to the human suffering, influenza epidemics also impose heavy demands on the health care system. For example, hospitals and intensive care units have limited excess capacity during infectious diseases epidemics. Therefore, it is important

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Klasson, Filip, and Patrik Väyrynen. "Development of an API for creating and editing openEHR archetypes." Thesis, Linköping University, Department of Biomedical Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17558.

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<p>Archetypes are used to standardize a way of creating, presenting and distributing health care data. In this master thesis project the open specifications of openEHR was followed. The objective of this master thesis project has been to develop a Java based API for creating and editing openEHR archetypes. The API is a programming toolbox that can be used when developing archetype editors. Another purpose has been to implement validation functionality for archetypes. An important aspect is that the functionality of the API is well documented, this is important to ease the understanding of the

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Haen, Roel. "Breast cancer related lymphedema." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:c4a83ffc-790f-46ec-bde2-3ac639dd7c89.

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Improvements in the treatment of breast cancer have resulted in better survival rates and less breast cancer related morbidity. Nevertheless, a significant group of patients still experience a diminished quality of life as a result of lymphedema. In the early, often reversible, stage of lymphedema patients can experience subjective changes in the affected area. However, with the traditionally available tools the lymphedema often remains clinically undetectable and patients are denied essential care that can prevent worsening. Furthermore, most lymphedema assessment tools fail to support a clea

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González, Ballester Miguel Ángel. "Morphometric analysis of brain structures in MRI." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:9b70d5d7-5a38-454c-b545-696b726092b8.

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Medical computer vision is a novel research discipline based on the application of computer vision methods to data sets acquired via medical imaging techniques. This work focuses on magnetic resonance imaging (MRI) data sets, particularly in studies of schizophrenia and multiple sclerosis. Research on these diseases is challenged by the lack of appropriate morphometric tools to accurately quantify lesion growth, assess the effectiveness of a drug treatment, or investigate anatomical information believed to be evidence of schizophrenia. Thus, most hypotheses involving these conditions remain un

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Fiebig, Michael. "Characterisation of the transcriptomes of Leishmania mexicana promastigotes and amastigotes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ff1a5033-e1a4-40cc-8204-7de904ba7aa2.

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Leishmania spp. undergo substantial adaptations from being promastigotes, found in sandflies, to being amastigotes, residing in parasitophorous vacuoles within mammalian macrophages. In the past, microarray studies have sought to elucidate these adaptations using axenic amastigote systems or amastigotes purified from host-cells, raising the question whether the observed transcriptomic signatures were a true reflection of intracellular amastigotes. Moreover, with ever-improving genome annotations being available, it is clear that these studies failed to address the transcriptomic behaviour of a

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Tsanas, Athanasios. "Accurate telemonitoring of Parkinson's disease symptom severity using nonlinear speech signal processing and statistical machine learning." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572585.

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This study focuses on the development of an objective, automated method to extract clinically useful information from sustained vowel phonations in the context of Parkinson’s disease (PD). The aim is twofold: (a) differentiate PD subjects from healthy controls, and (b) replicate the Unified Parkinson’s Disease Rating Scale (UPDRS) metric which provides a clinical impression of PD symptom severity. This metric spans the range 0 to 176, where 0 denotes a healthy person and 176 total disability. Currently, UPDRS assessment requires the physical presence of the subject in the clinic, is subjective

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Hrudíková, Radka. "Vytipování a sledování exprese genů ovlivňujících syntézu kyseliny hyaluronové ve streptococcus equi subsp. zooepidemicus pomocí technologie dna čipů a real time PCR." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-432922.

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Hyaluronic acid (HA) is an important substance, which is mostly used in pharmaceutical and cosmetic industry. This substance is commonly found in the human body. HA is one of the factors contributing to virulence of microorganisms. Some bacterial strains produce hyaluronic acid in the form of a mucoid capsule that encapsulates the cell to protect bacteria against the immune system of the host organism. One of the main producers is the bacterial strain Streptococcus equi subsp. zooepidemicus. Contipro a.s. uses the strain CO4A to produce hyaluronic acid in large scale. The production strain was

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Casero, Cañas Ramón. "Left ventricle functional analysis in 2D+t contrast echocardiography within an atlas-based deformable template model framework." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:b17b3670-551d-4549-8f10-d977295c1857.

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This biomedical engineering thesis explores the opportunities and challenges of 2D+t contrast echocardiography for left ventricle functional analysis, both clinically and within a computer vision atlas-based deformable template model framework. A database was created for the experiments in this thesis, with 21 studies of contrast Dobutamine Stress Echo, in all 4 principal planes. The database includes clinical variables, human expert hand-traced myocardial contours and visual scoring. First the problem is studied from a clinical perspective. Quantification of endocardial global and local funct

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Pelicaen, Rudy. "Genome-scale metabolic modeling of candidate functional starter cultures for cocoa bean fermentation." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/308886.

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Cocoa bean fermentation is an essential but spontaneous fermentation process to obtain the necessary raw material for the production of cocoa-derived products, among which chocolate. Successful cocoa bean fermentation processes are typically dominated by three microbial groups, namely yeasts, lactic acid bacteria, and acetic acid bacteria. The use of functional starter cultures may allow to gain a better control over the fermentation process. Previously, a number of candidate functional starter cultures have been proposed for the lactic acid bacteria, namely Lactobacillus fermentum 222 and Lac

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Traore, Seydou. "Computational approaches toward protein design." Thesis, Toulouse, INSA, 2014. http://www.theses.fr/2014ISAT0033/document.

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Le Design computationnel de protéines, en anglais « Computational Protein Design » (CPD), est un champ derecherche récent qui vise à fournir des outils de prédiction pour compléter l'ingénierie des protéines. En effet,outre la compréhension théorique des propriétés physico-chimiques fondamentales et fonctionnelles desprotéines, l’ingénierie des protéines a d’importantes applications dans un large éventail de domaines, y comprisdans la biomédecine, la biotechnologie, la nanobiotechnologie et la conception de composés respectueux del’environnement. Le CPD cherche ainsi à accélérer le design de p

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Agier, Marie. "De l'analyse de données d'expression à la reconstruction de réseau de gènes." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2006. http://tel.archives-ouvertes.fr/tel-00717382.

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Le premier aspect de ce travail concerne le pré-traitement et l'analyse de données d'expression dans le cadre de deux principaux projets dont l'objectif global est d'améliorer le diagnostic et le pronostic du cancer du sein et de mieux cibler les traitements. Un processus de pré-traitement des données d'expression optimisé a été mis en place et plusieurs analyses ont été réalisées et ont permis d'identifier des gènes permettant de mettre en evidence un profil d'expression caractéristique du statut ganglionnaire des patientes et de la réponse thérapeutique à un traitement chimiothérapeutique pa

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Mao, Linyong. "Application of Data Pipelining Technology in Cheminformatics and Bioinformatics." Thesis, 2002. http://hdl.handle.net/1805/322.

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Submitted to the faculty of the University Graduate School in partial fulfillment of the requirements for the degree Master of Sciences in the School of Informatics Indiana University December 2002<br>Data pipelining is the processing, analysis, and mining of large volumes of data through a branching network of computational steps. A data pipelining system consists of a collection of modular computational components and a network for streaming data between them. By defining a logical path for data through a network of computational components and configuring each component accordingly, a user

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Kuo, Yu-Lun, and 郭育倫. "Apply Cluster and Grid Computing Technology to Bioinformatics Applications." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/94838111871331986029.

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碩士<br>東海大學<br>資訊工程與科學系<br>92<br>In addition to the traditional massively parallel computers, distributed workstation clusters now play an important role in scientific computing perhaps due to the advent of commodity high performance processors, low-latency/high-band width networks and powerful development tools. As we know, bioinformatics tools can speed up the analysis of large-scale sequence data, especially about sequence alignment. Because the biology data set is large and need high throughput analysis and computation, we must use a lot of supercomputer to analyze the biology sequence. But

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Phillips, Andrew Bartlett. "An Integrative Review of the Literature on Technology Transformation in Healthcare." Thesis, 2012. https://doi.org/10.7916/D8JH3T8T.

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Healthcare transformation through technology is a core objective of health reform. It is important for decision makers to understand the likelihood that reform policies will in fact transform. This study evaluates evidence of technology transformation in healthcare through an integrative review of the healthcare and business literature, guided by the theory of punctuated equilibrium (TPE). TPE describes the process of transformation within organizations, markets, and groups. The theory explains transformation as a pattern of long periods of incremental change (equilibrium) punctuated by short

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Lai, Shu-Mei, and 賴淑美. "Apply the Emerging Technology of Web Services to Integrate Bioinformatics Resources." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/31329292239450383924.

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碩士<br>國立陽明大學<br>衛生資訊與決策研究所<br>91<br>Over the past few years, numerous organizations and people have developed various applications and generate biological data host in the bioinformatics field. Most biology analytic software tool has specific function. For laboratory experiment result, biologist researcher needs to synthesize the knowledge from varied databases and software resources. Therefore, integration of biology analytic resources is the essential work. However, the button-up approach of resource development resulted in incompatible problem between the software tools. Some

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Yen-Jen, Shih, and 施彥任. "A Study on the Integration of Heterogeneous Bioinformatics Resources based on Component Technology." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/39575388076088068372.

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碩士<br>長庚大學<br>資訊管理研究所<br>91<br>Lots of bioinformatics databases and software analysis tools are generated in the post-genome era. These bioinformatics resources work on different kinds of operation systems and database format. This study tried to solve the integration of the Heterogeneous bioinformatics resources. In this study, the Enterprise JavaBeans (EJB) software component technology is introduced for the system integration of bioinformatics resources, the eXtensible Markup Language (XML) technology is recommended as data interchange transfer format among heterogeneous database

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