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Journal articles on the topic 'BioInorganic Chemistry, Medicinal Chemistry'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Nurchi, Valeria M., and Guido Crisponi. "Editorial: Applications of Medicinal Bioinorganic Chemistry." Current Medicinal Chemistry 25, no. 1 (2018): 3–4. http://dx.doi.org/10.2174/092986732501180122141500.

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2

Schatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Edited by Enzo Alessio." Angewandte Chemie International Edition 50, no. 46 (2011): 10765–67. http://dx.doi.org/10.1002/anie.201104828.

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3

Schatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Herausgegeben von Enzo Alessio." Angewandte Chemie 123, no. 46 (2011): 10953–55. http://dx.doi.org/10.1002/ange.201104828.

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4

Kostova, Irena. "Editorial to the Special Issue: “Synthesis of Organic Ligands and Their Metal Complexes in Medicinal Chemistry”." Molecules 27, no. 11 (2022): 3644. http://dx.doi.org/10.3390/molecules27113644.

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5

Cohen, Seth M. "New approaches for medicinal applications of bioinorganic chemistry." Current Opinion in Chemical Biology 11, no. 2 (2007): 115–20. http://dx.doi.org/10.1016/j.cbpa.2007.01.012.

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6

Reedijk, Jan. "Bioinorganic chemistry." Science of Nature 74, no. 2 (1987): 71–77. http://dx.doi.org/10.1007/bf00366080.

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7

Erxleben, Andrea. "Transition metal salen complexes in bioinorganic and medicinal chemistry." Inorganica Chimica Acta 472 (March 2018): 40–57. http://dx.doi.org/10.1016/j.ica.2017.06.060.

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8

Ravichandran, S., R. M. Madhumitha Sri, Mahrukh Mehraj, and Chundru Sowmya. "The importance of transition metals as drug." International Journal of Clinical Biochemistry and Research 9, no. 1 (2022): 1–3. http://dx.doi.org/10.18231/j.ijcbr.2022.001.

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The last few decades have seen enormous advances in the area of bioinorganic chemistry, attracting scientists from various disciplines including chemistry, biology, agriculture and medicine. Metals are very important constituents preferred by nature that function in bio-chemical method for living organisms. Metal complexes are essential in the area of catalysis, material science, photochemistry and bio systems. Medicinal chemistry may exploit the unique feature of metal ions in concern with design of new drugs. The recent advancement in emerging field of inorganic chemistry, the act of transit

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9

Nurchi, Valeria M. "Medicinal bio-inorganic chemistry: papers from the Third International Summer School of Bioinorganic Medicinal Chemistry, Cagliari, Italy." Journal of Inorganic Biochemistry 199 (October 2019): 110798. http://dx.doi.org/10.1016/j.jinorgbio.2019.110798.

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10

Bhabak, Krishna P., Bhaskar J. Bhuyan, and Govindasamy Mugesh. "Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes." Dalton Transactions 40, no. 10 (2011): 2099. http://dx.doi.org/10.1039/c0dt01057j.

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11

Guo, Zijian, and Jing Zhao. "Editorial overview: Bioinorganic chemistry: Bio-medicinal functions of metal complexes." Current Opinion in Chemical Biology 43 (April 2018): A4—A5. http://dx.doi.org/10.1016/j.cbpa.2018.02.013.

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12

Andrade, Marta A., and Luísa M. D. R. S. Martins. "Novel Chemotherapeutic Agents - The Contribution of Scorpionates." Current Medicinal Chemistry 26, no. 41 (2020): 7452–75. http://dx.doi.org/10.2174/0929867325666180914104237.

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: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate comp

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13

Constable, Edwin C., Catherine E. Housecroft, Marc Creus, et al. "Bioorganic and Bioinorganic Chemistry." CHIMIA International Journal for Chemistry 64, no. 12 (2010): 846–54. http://dx.doi.org/10.2533/chimia.2010.846.

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14

Chayen, J. "Principles of bioinorganic chemistry." Cell Biochemistry and Function 13, no. 2 (1995): 153–54. http://dx.doi.org/10.1002/cbf.290130214.

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15

Vignais, P. "The bioinorganic chemistry of nickel." Biochimie 72, no. 5 (1990): 375–76. http://dx.doi.org/10.1016/0300-9084(90)90036-g.

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16

Keppler, Bernhard, Markus Galanski, and Annette Rompel. "Editorial: Topics in Bioinorganic Chemistry." Chemistry & Biodiversity 5, no. 8 (2008): 1435–36. http://dx.doi.org/10.1002/cbdv.200890133.

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17

Dawson, John H. "Bioinorganic chemistry: principles and practice." Chemistry & Biology 2, no. 3 (1995): 137–38. http://dx.doi.org/10.1016/1074-5521(95)90067-5.

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18

Rybak-Akimova, Elena. "Bioinorganic chemistry: A short course." Applied Biochemistry and Biotechnology 104, no. 2 (2003): 157–58. http://dx.doi.org/10.1007/s12010-003-0002-5.

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19

Notaro, Anna, and Gilles Gasser. "First Workshop on Metals in Medicine (2019): Translational Research in Medicinal Bioinorganic Chemistry." ChemBioChem 21, no. 19 (2020): 2706–7. http://dx.doi.org/10.1002/cbic.202000329.

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20

Tyeklar, Zoltan, and Kenneth D. Karlin. "Copper-dioxygen chemistry: a bioinorganic challenge." Accounts of Chemical Research 22, no. 7 (1989): 241–48. http://dx.doi.org/10.1021/ar00163a003.

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21

Orzeł, Łukasz, Maria Oszajca, Justyna Polaczek, Dominika Porębska, Rudi van Eldik, and Grażyna Stochel. "High-Pressure Mechanistic Insight into Bioinorganic NO Chemistry." Molecules 26, no. 16 (2021): 4947. http://dx.doi.org/10.3390/molecules26164947.

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Pressure is one of the most important parameters controlling the kinetics of chemical reactions. The ability to combine high-pressure techniques with time-resolved spectroscopy has provided a powerful tool in the study of reaction mechanisms. This review is focused on the supporting role of high-pressure kinetic and spectroscopic methods in the exploration of nitric oxide bioinorganic chemistry. Nitric oxide and other reactive nitrogen species (RNS) are important biological mediators involved in both physiological and pathological processes. Understanding molecular mechanisms of their interact

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22

Iakovidis, Isidoros, Ioannis Delimaris, and Stylianos M. Piperakis. "Copper and Its Complexes in Medicine: A Biochemical Approach." Molecular Biology International 2011 (June 15, 2011): 1–13. http://dx.doi.org/10.4061/2011/594529.

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The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of a novel generation of highly active drugs with minimized side effects which c

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23

Armstrong, Andrea F., and John F. Valliant. "The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy." Dalton Transactions, no. 38 (2007): 4240. http://dx.doi.org/10.1039/b709843j.

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24

Kravchik, M. V., I. A. Novikov, S. Yu Petrov, and S. E. Avetisov. "Bioinorganic chemistry of open-angle glaucoma: A review." Journal of Trace Elements in Medicine and Biology 62 (December 2020): 126652. http://dx.doi.org/10.1016/j.jtemb.2020.126652.

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25

Kola, Arian, Federico Nencioni, and Daniela Valensin. "Bioinorganic Chemistry of Micronutrients Related to Alzheimer’s and Parkinson’s Diseases." Molecules 28, no. 14 (2023): 5467. http://dx.doi.org/10.3390/molecules28145467.

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Metal ions are fundamental to guarantee the regular physiological activity of the human organism. Similarly, vitamins play a key role in many biological functions of the metabolism, among which are coenzymes, redox mediators, and antioxidants. Due to their importance in the human organism, both metals and vitamins have been extensively studied for their involvement in neurodegenerative diseases (NDs). However, the full potential of the interaction between vitamins and metal ions has not been fully explored by researchers yet, and further investigation on this topic is needed. The aim of this r

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26

Thorp, H. Holden. "Bioinorganic chemistry and drug design: here comes zinc again." Chemistry & Biology 5, no. 6 (1998): R125—R127. http://dx.doi.org/10.1016/s1074-5521(98)90166-1.

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27

Maurya, R. C., and H. Singh. "Oxovanadium(IV) Complexes Involving O,O‐Donor Environment of Bioinorganic and Medicinal Relevance." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 34, no. 2 (2004): 269–90. http://dx.doi.org/10.1081/sim-120028301.

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28

Sanjeev Kumar and Naresh Kumar. "Synthesis, Characterization of Trinuclear Containing Se (II) Donar Group of Ni (II) Complexes." International Journal of Scientific Research in Science and Technology 12, no. 2 (2025): 591–95. https://doi.org/10.32628/ijsrst251222601.

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For many years, metal complexes have piqued attention. Selenium atoms play key role in coordination of metal at the active sites of numerious metal biomolecules. The development of the field of bioinorganic chemistry has increased the interest in complexes of Selenium and serve as multifunctional properties. In view of contribution of studies on Selenium complexes containing ligands, we have prepared trinuclear complexes of Selenium (II) having formula [Se2NiMcBr2]. Selenium is an essential component of several measure metabolic pathways, including thyroid hormone metabolism antioxidant defenc

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29

Meyer, Franc. "Bioinorganic Chemistry. A Short Course. Von Rosette M. Roat-Malone." Angewandte Chemie 115, no. 48 (2003): 6104. http://dx.doi.org/10.1002/ange.200385959.

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30

Bryan, R. F. "Bioinorganic chemistry: inorganic elements in the chemistry of lifr by W. Kaim and B. Swederski." Acta Crystallographica Section B Structural Science 51, no. 2 (1995): 264. http://dx.doi.org/10.1107/s010876819509985x.

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31

Hecel, Aleksandra, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek, and Henryk Kozlowski. "Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy." Current Medicinal Chemistry 26, no. 4 (2019): 624–47. http://dx.doi.org/10.2174/0929867324666170920125943.

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Silver is a non-essential element with promising antimicrobial and anticancer properties. This work is a detailed summary of the newest findings on the bioinorganic chemistry of silver, with a special focus on the applications of Ag+ complexes and nanoparticles. The coordination chemistry of silver is given a reasonable amount of attention, summarizing the most common silver binding sites and giving examples of such binding motifs in biologically important proteins. Possible applications of this metal and its complexes in medicine, particularly as antibacterial and antifungal agents and in can

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32

Klein, Axel. "Bioinorganic Chemistry: A Practical Course. Von Nils Metzler-Nolte und Ulrich Schatzschneider." Angewandte Chemie 122, no. 13 (2010): 2329–30. http://dx.doi.org/10.1002/ange.200906918.

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33

Nogueira, Thais Cristina Mendonça, Lucas dos Santos Cruz, Maria Cristina Lourenço, and Marcus Vinicius Nora de Souza. "Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus." Letters in Drug Design & Discovery 16, no. 7 (2019): 792–98. http://dx.doi.org/10.2174/1570180815666180627122055.

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Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chemistry because of their structure and functionalities and are also used in bioinorganic chemistry as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from commercial pyridoxal hydrochloride and

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34

Gailer, Jürgen. "Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases." International Journal of Molecular Sciences 25, no. 6 (2024): 3393. http://dx.doi.org/10.3390/ijms25063393.

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The ongoing anthropogenic pollution of the biosphere with As, Cd, Hg and Pb will inevitably result in an increased influx of their corresponding toxic metal(loid) species into the bloodstream of human populations, including children and pregnant women. To delineate whether the measurable concentrations of these inorganic pollutants in the bloodstream are tolerable or implicated in the onset of environmental diseases urgently requires new insight into their dynamic bioinorganic chemistry in the bloodstream–organ system. Owing to the human exposure to multiple toxic metal(loid) species, the mech

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35

Bhowmik, K. R. Nath. "Biomedical Applications of Some Schiff Bases and Their Transition Metal Complexes: A Review." Asian Journal of Chemistry 36, no. 11 (2024): 2485–500. http://dx.doi.org/10.14233/ajchem.2024.32594.

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A diverse class of compounds known as Schiff bases and their metal complexes are synthesized via condensation of amino and carbonyl compounds. Schiff bases and their metal complexes have several applications in analytical, pharmacological, organic, bioinorganic, and material research, which has increased interest in this class of molecule. In a variety of reactions, even in the presence of moisture, many Schiff base metal complexes have outstanding catalytic activity. Schiff bases serve as versatile pharmacophores due to their ability to bind with metals of different oxidation states to form c

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36

Freisinger, Eva, and Roland K. O. Sigel. "The Bioinorganic Periodic Table." CHIMIA International Journal for Chemistry 73, no. 3 (2019): 185–93. http://dx.doi.org/10.2533/chimia.2019.185.

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37

Tialiou, Alexia, Jiamin Chin, Bernhard K. Keppler, and Michael R. Reithofer. "Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment." Biomedicines 10, no. 6 (2022): 1417. http://dx.doi.org/10.3390/biomedicines10061417.

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Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acy

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38

Johnstone, Timothy C., and Stephen J. Lippard. "Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]." JBIC Journal of Biological Inorganic Chemistry 19, no. 4-5 (2014): 667–74. http://dx.doi.org/10.1007/s00775-014-1109-6.

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39

Gupta, Rupal, Jenna Yehl, Mingyue Li, and Tatyana Polenova. "51V magic angle spinning NMR spectroscopy and quantum chemical calculations in vanadium bio-inorganic systems: current perspective." Canadian Journal of Chemistry 93, no. 9 (2015): 929–37. http://dx.doi.org/10.1139/cjc-2014-0557.

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In recent years, 51V magic angle spinning (MAS) NMR spectroscopy has been widely used to characterize vanadium centers in biology, biomimetic complexes, and inorganic compounds of medicinal and industrial relevance. It has been demonstrated that 51V NMR parameters are sensitive probes of the coordination geometry and chemical environment of the metal center, beyond the first coordination sphere. To establish the relationships between NMR parameters and structure of the vanadium centers, over the past decade a large series of coordination complexes have been analyzed by MAS NMR spectroscopy. It

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40

Watly, Joanna, Aleksandra Hecel, Paulina Kolkowska, Henryk Kozlowski, and Magdalena Rowinska-Zyrek. "Poly-Xaa Sequences in Proteins - Biological Role and Interactions with Metal Ions: Chemical and Medical Aspects." Current Medicinal Chemistry 25, no. 1 (2018): 22–48. http://dx.doi.org/10.2174/0929867324666170428104928.

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Background: The understanding of the bioinorganic and coordination chemistry of metalloproteins containing unusual poly-Xaa sequences, in which a single amino acid is repeated consecutively, is crucial for describing their metal binding-structure-function relationship, and therefore also crucial for understanding their medicinal potential. To the best of our knowledge, this is the first systematic review on metal complexes with polyXaa sequences. Methods: We performed a thorough search of high quality peer reviewed literature on poly-Xaa type of sequences in proteins, focusing on their biologi

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41

Martins, Francisco Mainardi, Yuri Clemente Andrade Sokolovicz, Morgana Maciél Oliveira, Carlos Serpa, Otávio Augusto Chaves, and Davi Fernando Back. "Synthesis, Structural Characterization, and In Silico Antiviral Prediction of Novel DyIII-, YIII-, and EuIII-Pyridoxal Helicates." Inorganics 13, no. 8 (2025): 252. https://doi.org/10.3390/inorganics13080252.

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The synthesis and structural characterization of three new triple-stranded helical complexes ([Dy2(L2)3]2Cl∙15H2O (C1), [Y2(L2)3]3(NO3)Cl∙14H2O∙DMSO (C2), and [Eu2(L4)3]∙12H2O (C3), where L2 and L4 are ligands derived from pyridoxal hydrochloride and succinic or adipic acid dihydrazides, respectively, were described. The X-ray data, combined with spectroscopic measurements, indicated that L2 and L4 act as bis-tridentate ligands, presenting two tridentate chelating cavities O,N,O to obtain the dinuclear complexes C1–C3. Their antiviral profile was predicted via in silico calculations in terms o

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42

Enass J. Waheed1, Ali M. A. Al-khazraji2, and Awf A. R. Ahmed3. "Nanogold-Bound Copper Complexes and Their Various Applications: A Review Article." Journal of Kufa for Chemical Sciences 2, no. 10 (2023): 270–89. http://dx.doi.org/10.36329/jkcm/2023/v2.i10.12497.

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The term "nano gold," also known as "gold nanoparticles," is commonly used. These particles are extremely small, with a diameter of less than 100 nm, which is only a fraction of the width of a human hair. Due to their tiny size, nano gold particles are often found in a colloidal solution, where they are suspended in a liquid stabilizer. This colloidal gold is essentially another name for nano gold. The main method for producing gold nanoparticles in a colloidal solution is the citrate synthesis technique, which involves combining different solutions to precipitate the gold nanoparticles[1-5].

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43

Rabinovich, Mikhail L. "Concepts and Models in Bioinorganic Chemistry. By Heinz-Bernhard Kraatz and Niels Metzler-Nolte." Biotechnology Journal 3, no. 3 (2008): 420–21. http://dx.doi.org/10.1002/biot.200890031.

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44

Kostova, Irena. "Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7." Molecules 29, no. 4 (2024): 824. http://dx.doi.org/10.3390/molecules29040824.

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With the progression in the field of bioinorganic chemistry, the role of transition metal complexes as the most widely used therapeutics is becoming a more and more attractive research area. The complexes of transition metals possess a great variety of attractive pharmacological properties, including anticancer, anti-inflammatory, antioxidant, anti-infective, etc., activities. Transition metal complexes have proven to be potential alternatives to biologically active organic compounds, especially as antitumor agents. The performance of metal coordination compounds in living systems is anticipat

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45

Leone, Linda, Flavia Nastri, and Angela Lombardi. "Natural, Designed and Engineered Metalloenzymes: Structure, Catalytic Mechanisms and Applications." International Journal of Molecular Sciences 24, no. 18 (2023): 14255. http://dx.doi.org/10.3390/ijms241814255.

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46

Meggers, Eric. "Concepts and Models in Bioinorganic Chemistry. Edited by Heinz-Bernhard Kraatz and Nils Metzler-Nolte." ChemBioChem 8, no. 1 (2007): 145. http://dx.doi.org/10.1002/cbic.200600395.

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47

Stoppa, Valentina, Edoardo Battistel, Marco Baron, et al. "Dinuclear gold(I) Complexes with Bidentate NHC Ligands as Precursors for Alkynyl Complexes via Mechanochemistry." Molecules 27, no. 13 (2022): 4317. http://dx.doi.org/10.3390/molecules27134317.

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The use of alkynyl gold(I) complexes covers different research fields, such as bioinorganic chemistry, catalysis, and material science, considering the luminescent properties of the complexes. Regarding this last application, we report here the synthesis of three novel dinuclear gold(I) complexes of the general formula [(diNHC)(Au-C≡CPh)2]: two Au-C≡CPh units are connected by a bridging di(N-heterocyclic carbene) ligand, which should favor the establishment of semi-supported aurophilic interactions. The complexes can be easily synthesized through mechanochemistry upon reacting the pristine dib

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48

Tsantis, Sokratis T., Demetrios I. Tzimopoulos, Malgorzata Holynska, and Spyros P. Perlepes. "Oligonuclear Actinoid Complexes with Schiff Bases as Ligands—Older Achievements and Recent Progress." International Journal of Molecular Sciences 21, no. 2 (2020): 555. http://dx.doi.org/10.3390/ijms21020555.

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Even 155 years after their first synthesis, Schiff bases continue to surprise inorganic chemists. Schiff-base ligands have played a major role in the development of modern coordination chemistry because of their relevance to a number of interdisciplinary research fields. The chemistry, properties and applications of transition metal and lanthanoid complexes with Schiff-base ligands are now quite mature. On the contrary, the coordination chemistry of Schiff bases with actinoid (5f-metal) ions is an emerging area, and impressive research discoveries have appeared in the last 10 years or so. The

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49

Maurya, R. C., and S. Rajput. "Oxovanadium(IV) complexes of bioinorganic and medicinal relevance: synthesis, characterization, and 3D molecular modeling and analysis of some oxovanadium(IV) complexes involving O,O-donor environment." Journal of Molecular Structure 687, no. 1-3 (2004): 35–44. http://dx.doi.org/10.1016/j.molstruc.2003.08.023.

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50

Shaik, Sason. "Computational Inorganic and Bioinorganic Chemistry. Herausgegeben von Edward I. Solomon, Robert A. Scott und R. Bruce King." Angewandte Chemie 122, no. 18 (2010): 3177–79. http://dx.doi.org/10.1002/ange.201000436.

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