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Journal articles on the topic "(Biol.)"
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Cotrina Cabello, Guillermo Gomer, Lorgio Noel Masgo Sanchez, Yosely Yomayra Tumbay Ambrocio, Italo Wile Alejos Patiño, Pedro Córdova Mendoza, and Alberto Rivelino Patiño Rivera. "Efectos del biol y súper biol en la producción agroecológica de la lechuga (lactuca sativa) variedad seda en el centro poblado de Chinchopampa –Chaglla – Pachitea – Huánuco." Julio-Diciembre 2020, no. 3 (July 6, 2020): 17–31. http://dx.doi.org/10.47058/joa3.2.
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El trabajo de investigación se realizó con el objetivo de conocer el efecto y rendimiento del biol y súper biol en la producción agroecológica de lechuga (lactuca sativa) variedad: “seda”. Se realizó en una parcela del C.P. Chinchopampa del Distrito de Chaglla-Huánuco. Las concentraciones estudiadas de biol y súper biol fueron 5%, 7.5% y 10%, y se aplicaron a 200 plantas de lechuga por tratamiento, cuya duración de la investigación fue 100 días. El diseño experimental fue el Diseño Completamente Azar, se evaluó: altura, diámetro, peso, análisis fisicoquímico, análisis organoléptico y microbiológico. Los tratamientos estudiados fueron la concentración de biol y súper biol al 5% (T1), 7.5% (T2), 10% (T3) y testigo (T0), se colocó 10 plantas de lechugas por tratamiento. Se realizó la prueba de significación de Duncan al 5%. Los resultados mostraron, que el tratamiento T3 de súper biol con 10% obtuvieron mayor diámetro 19.65 cm, peso 557.5 g y altura de 10.83 cm y el T2 con biol con 7.5 % el diámetro fue de 16.50 cm, peso 428.2 g y altura 9.48 cm. Así mismo las características isicoquímicas de la lechuga, el pH y acidez resultaron por encima de los valores permitidos, por ser cultivadas en suelos ácidos. Con relación a las características microbiológicas de Escherichia coli y Salmonella resultó que todos los tratamientos estaban bajo los límites permisibles. En el análisis organoléptico la mejor aceptación en textura y apariencia fue el T2 con súper biol con 7.5%. La relación beneficio costo: biol resultó siendo de 3.37 y por cada sol invertido se gana 2.37 soles, en súper biol se obtuvo 3.09 y por cada sol invertido se gana 2.09 soles. La aplicación del biol y súper biol es una alternativa ecológica para fertilizar cultivos, reduciendo el uso de fertilizantes químicos y los costos de producción.
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Mallén Rivera, Carlos. "BIOL. JUANA HUERTA CRESPO 1929 - 2011." Revista Mexicana de Ciencias Forestales 2, no. 5 (May 28, 2019): 3–4. http://dx.doi.org/10.29298/rmcf.v2i5.579.
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Hablar de la profesora Juana Huerta Crespo es hablar de toda una institución -en lo relativo a la enseñanza, investigación y servicio en el área forestal- debido a la relevancia de su trabajo que durante 54 años realizó en nuestro país, principalmente en la Universidad Autónoma Chapingo, donde en forma ininterrumpida y durante 46 años participó en la formación de un gran número de profesionistas forestales.
En el año de 1963, la bióloga Juana Huerta ingresó a la Escuela Nacional de Agricultura (ENA), hoy Universidad Autónoma Chapingo (UACh), para impartir clases. Hecho por demás trascendente, ya que fue de las primeras mujeres catedráticas en la ENA, junto con otras pioneras como la maestra Antonia González Embarcadero; así mismo, trabajaba en el entonces Instituto Nacional de Investigaciones Forestales (INIF), ubicado en el Distrito Federal, donde también vivía, lo que ocasionaba el traslado constante al Estado de México, entidad en la que se ubicaba la UACH.
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Day, P. L., W. C. Langston, and W. J. Darby. "Proc. SOc. Exp. Biol. and Med." Nutrition Reviews 37, no. 4 (April 27, 2009): 114–15. http://dx.doi.org/10.1111/j.1753-4887.1979.tb02227.x.
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Ploegh, Hidde. "A European slant on mol biol." Nature 413, no. 6857 (October 2001): 679–80. http://dx.doi.org/10.1038/35099630.
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Not Available, Not Available. "Corrigendum: Mar. Biol. 132: 21-28." Marine Biology 136, no. 2 (March 28, 2000): 378. http://dx.doi.org/10.1007/s002270050696.
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Gutierrez Arce, Felipe, Sandy Diaz Plasencia, Zulema Rojas Vásquez, Luis Asunción Vallejos Fernández, and Walter Gutierrez Arce. "Elaboración de abono orgánico (biol) para su utilización en la producción de alfalfa (Medicago sativa v. vicus) en Cajamarca." REVISTA PERSPECTIVA 20, no. 4 (February 7, 2020): 441–47. http://dx.doi.org/10.33198/rp.v20i2.00057.
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La presente investigación se llevó a cabo en el Fundo La Victoria, propiedad de la UniversidadNacional de Cajamarca, departamento de Cajamarca, ubicado en el distrito de Huacaríz Chicosector La Victoria. El objetivo de la investigación fue proponer la elaboración de biol como unaalternativa ecológica eficiente en la mejora de la producción de alfalfa, y, al mismo tiempo, disminuirel impacto ambiental producido por la ganadería. Los materiales utilizados para la obtencióndel biol fueron: estiércol de vacuno, suero de leche, agua, chancaca, sulfato de cobre, sulfato demagnesio, sulfato de zinc, clorato de calcio, bórax, y como elementos complementarios: sangrede vacuno, harina de huesos, vísceras de pollo y de pescado. A los 45 días de su elaboración, secosechó el biol, tomándose una muestra que fue enviada al laboratorio para el análisis químico deminerales. Los tratamientos en estudio fueron ubicados en tres parcelas de alfalfa cuya extensiónen cada una fue de 2 x 4 m2; el T0 fue el tratamiento testigo sin aplicación de biol, el T1 fue eltratamiento al que se le aplicó 5 cc de biol diluido en 5 litros de agua y el T2 fue el tratamientoal que se le aplico 7.5 cc de biol diluido en 5 litros de agua. La evaluación de los tratamientos seinició a los 10 días después del corte y en este mismo periodo se inició la aplicación del biol tantodel T1 como del T2 utilizando una bomba de mochila, luego a intervalos de 20, 30, 40 y 55 días.Al finalizar el último periodo de aplicación del biol, se procedió a medir la altura de la alfalfade los tres tratamientos en estudio, cuyo resultado fue de 62, 73 y 85 cm para cada tratamiento,respectivamente. También se procedió a medir la producción de alfalfa en Base Fresca (kg) yen Materia Seca (%), obteniéndose para T0, T1 y T2: 1,45, 1,98, 2,63, en base fresca, respectivamente;y 20.35, 21.04, 23.00 en Materia Seca, respectivamente. Se concluyó entonces quela aplicación de biol orgánico permite la optimización del recurso forrajero (alfalfa) y al mismotiempo se alza como una alternativa para mitigar el impacto ambiental causado por la ganadería.Palabras clave: Biol, estiércol, alfalfa, abono orgánico, Cajamarca, alternativa ecológica.
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Vogel, K., T. Opfermann, S. Wiegand, J. Biermann, M. Busch, T. Winkens, and M. Freesmeyer. "Relationship between estimated glomerular filtration rate and biological half-life of 131I." Nuklearmedizin 52, no. 05 (2013): 164–69. http://dx.doi.org/10.1055/s-0038-1625739.
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Summary Aim: This retrospective study sought to investigate the relationship between biological half-life (t 1/2 biol ) of 131I and estimated glomerular filtration rate (eGFR) in patients with thyroid carcinoma. Patients, methods: 96 patients with differentiated thyroid carcinoma (69 women, 27 men, mean age 64.0 ± 13.6 years) and diagnostic and therapeutic administration of 131I were considered. Patients with pronounced specific iodine storage were not included in the study. The eGFR was estimated according to the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula, the t 1/2 biol via dosimetry. Patients were subdivided in groups with normal clearance (NC) (n = 37, 38.5%), medium clearance (MC) (n = 48, 50.0%), and low clearance (LC) (n = 11, 11.5%) (eGFR _ 90; 60-89; 15-59 ml/min per 1.73 m2, respectively). The relationship between eGFR and t 1/2 biol of 131I was modeled using a power function. Results: The groups significantly differed in terms of age (NC 53.8, MC 68.6, and 78.0 years, respectively), serum creatinine levels (NC: 0.71; MC: 0.85; LC: 1.18 mg/dl), and t 1/2 biol (NC: 0.53; MC: 0.71; LC: 1.01 days). The t 1/2 biol was significantly influenced only by eGFR, and not by age, gender, or body weight. The relationship between t 1/2 biol of 131I and eGFR was described by the formula t 1/2 biol = 20.3 · eGFR−0.782. Conclusions: The calculated relationship between renal function and t 1/2 biol of 131I can be used in principle to estimate a dose reduction for patients with renal insufficiency. The model, however, gives erroneous results in individual cases and therefore a routine utilization cannot be recommended. Prospective studies are necessary, based on larger patient numbers and more accurate methods for dose rate measurement and GFR.
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DÍAZ, Percy, Cheryl TELLO, and Luis ARÉVALO-LÓPEZ. "EFECTO DEL USO DE TUTORES Y APLICACIÓN DE BIOFERTILIZANTES EN EL CRECIMIENTO Y DESARROLLO DE Plukenetia volubilis L. “SACHA INCHI”." Folia Amazónica 23, no. 2 (December 12, 2014): 119. http://dx.doi.org/10.24841/fa.v23i2.17.
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Se evaluó el efecto de dos tutores y cinco tipos de biofertilizantes en el crecimiento y desarrollo de Plukenetia volubilis L. sacha inchi en un suelo de baja fertilidad. La plantación se estableció utilizando el diseño de bloques completos al azar en parcelas divididas, siendo las parcelas principales dos sistemas de tutor y las sub parcelas cinco tipos de biofertilizantes. Los cinco biofertilizantes fueron: Biol, Biol mas frutos de Solanum torvum, Biol más hojas de Carica papaya, Biol más hojas de Cymbopogon citratus y Biol más hojas de Chondrodendron tomentosum, más un testigo (SB) por cada sistema de tutor, teniendo un total de doce tratamientos y tres bloques. Las dosis de aplicación fueron de 15 L.ha-1, divididas en aplicaciones quincenales a razón de 1.5 L.ha-1 en campo definitivo, las evaluaciones fueron realizadas cada quince días durante 5 meses. Los resultados indican que con los tratamientos T4 y T8 se redujeron los días para la fructificación, lográndose el mayor número de frutos con los tratamientos T4, T9 y T10, mejorando la productividad de plantas de P. volubilis L.
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Linares Gabriel, Ariadna, Catalino Jorge López-Collado, Mario Alejandro Hernández-Chontal, Joel Velasco-Velasco, and Gustavo López-Romero. "Application of soil amendments and their effect in the growth of heliconia." Ornamental Horticulture 24, no. 3 (September 28, 2018): 248–54. http://dx.doi.org/10.14295/oh.v24i3.1252.
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The Heliconias have a great potential as a cut flower and for this reason an adequate management of the crop is important. The objective of this research was the application of soil amendments (Biol and superabsorbent polymers - SAP) and the analysis on their effect in the growth of Heliconia psittacorum cv. Tropica. An experiment was established using a completely randomized design with four treatments and five repetitions: SAP (1 g plant-1), biol (20 mL plant-1) + SAP (1 g plant-1), biol (20 mL plant-1) and one control (without application). A 20 cm rhizome was planted per pot and were evaluated the height of the plant, the number of leaves, the leaf area and the number of shoots were measured. The analysis of variance did not show statistical differences (p ≤ 0.05) between treatments for the variables of the height of the plant, the leaf area and the number of shoots, but statistical differences were found for the variable number of leaves (p ≤ 0.05), and the best treatments were Biol, SAP, and Biol + SAP. With the application of the biol and SAP amendments, it was not possible to increase the plant height, the leaf area and the number of Heliconia shoots. Regarding the application of SAP to the not found significant results in Heliconia, it is expected that treatments with SAP show a better effect in the dry season.
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Lan, Weijie, and Don W. Cleveland. "A chemical tool box defines mitotic and interphase roles for Mps1 kinase." Journal of Cell Biology 190, no. 1 (July 12, 2010): 21–24. http://dx.doi.org/10.1083/jcb.201006080.
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In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments.
Dissertations / Theses on the topic "(Biol.)"
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Quintero, Emmeris Ivan Quintero. "Insumos e indicadores Biol?gicos em Agrossistemas com Bananeiras." Universidade Federal Rural do Rio de Janeiro, 2010. https://tede.ufrrj.br/jspui/handle/jspui/1165.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Studies were performed in the experimental area of Embrapa Agrobiologia, region - RJ, in order to evaluate the association of arbuscular mycorrhizal fungi (AMF) with a variety of banana ?Grand nine ", and the potential antagonist in AMF biocontrol nematodes. We also tested biological indicators and products as alternatives to monitoring and restoration of ecosystems with bananas. The first study evaluated the microbial activity in soil samples from two management systems with bananas in the municipality of Casimiro de Abreu, RJ. In the second study, was evaluated the AGAS organic product for the control of nematodes in banana. In the third, was evaluated the potential antagonist in AMF biocontrol nematode Radophulus similis and their contribution in the development of banana plants in the greenhouse. In the fourth study was estimated the effect of using two management systems with bananas in the community of soil fauna in Casimiro de Abreu, RJ. The indices of diversity, richness and density of macrofauna groups was calculate in each system. The results indicated no significant differences between management systems in relation to carbon and nitrogen levels of microbial biomass and soil organic carbon ratio vs. carbon microbial biomass in each season, while the variables soil basal respiration and metabolic quotient indicated that the organic farming system was greater efficiency of microbial biomass and the use of substrate by soil microorganisms than the system with conventional tillage. The organic product AGAS showed significant difference in population of the nematode Meloidogyne spp. and Radophulus similis both in samples of roots after 60 days of treated. In the field was control to phytoparasitic R. similis with the AGAS treatment showing a decrease in soil at 120 days. In the laboratory tests were performed with R. similis and the results demonstrated that the effects of exposure of nematodes to organic product showed a high percentage of control, especially in higher dosages with a 100% with respect to the nematicide effect in Radophulus. Regarding the development of plants in treatments with species of arbuscular mycorrhizal fungi inoculated in banana no significant difference. The foliar phosphorus analyzed varied significantly in the treatment with the fungus Scutellospora calospora, and foliar calcium and magnesium for the treatments with fungi: S. calospora, Entrhopospora colombiana and S. calospora + Glomus clarum. AMF reduced the population of the nematode R. similis in roots of banana plants in a greenhouse, and S. calospora and G. clarum were the most efficient. In soil macrofauna results indicated a reduction in the banana organic system, with lower density and lower richness of taxonomic groups when compared with the conventional system. The group of decomposers and predators showed better soil quality in organic farming system especially in the summer due to its greater diversity and density at this season of year.
Os trabalhos foram realizados com o objetivo de avaliar a associa??o de fungos micorr?zicos arbusculares (FMAs) com a variedade de banana ?Grand nine?, e o potencial antagonista dos FMAs no biocontrole dos nemat?ides. Tamb?m foram testados indicadores e insumos biol?gicos como alternativas para recupera??o e monitoramento de ecossistemas pertubados com bananeiras. O primeiro estudo avaliou a atividade microbiana do solo em amostras de dois sistemas de manejo com bananeiras no municipio de Casimiro de Abreu, RJ. No segundo estudo avaliou-se o insumo org?nico com ?cido glut?mico e saponinas (AGAS) para o controle de nemat?ides em bananeiras na Pesagro, Serop?dica, RJ. O terceiro avaliou o potencial antagonista dos FMAs no biocontrole do nemat?ide Radophulus similis e seu aporte no desenvolvimento de plantas de bananeira em casa de vegeta??o da Embrapa Agrobiologia. No quarto estudo se estimou o efeito do uso de dois sistemas de manejo com bananeiras na comunidade da macrofauna ed?fica em Casimiro de Abreu, RJ. Foram calculados os ?ndices de biodiversidade, riqueza e densidade dos grupos de macrofauna em cada sistema. Os resultados indicaram que n?o houve diferen?a significativa entre sistemas de manejo com rela??o a valores de carbono e nitrog?nio da biomassa microbiana, e rela??o carbono org?nico vs carbono da biomassa microbiana nas ?pocas de ver?o e inverno, enquanto que as vari?veis respira??o basal do solo e quociente metab?lico indicaram que no sistema com cultivo org?nico houve uma maior efici?ncia da biomassa microbiana e do uso do substrato pelos microorganismos do solo do que o sistema com cultivo convencional. O produto org?nico AGAS proporcionou uma redu??o nos ?ndices populacionais de Meloidogyne spp nas doses de 1,51 e 2,02 ml.cm?? e de Radophulus similis na dose de 2,02 ml.cm?? ambos nas amostras de ra?zes ap?s 60 dias das plantas serem tratadas. No campo houve redu??o da popul??o de R. similis no solo aos 120 dias ap?s o tratamento com AGAS nas doses de 0,5 e 1,0 ml.cm??. No laborat?rio, quando diferentes estadios de R. similis foram expostos ao produto AGAS nas doses 1,0; 1,5 e 2,0 ml.m?? observou-se uma alta taxa de mortalidade chegando a 100% nas doses mais altas demonstrando efeito nematicida ?in vitro?. Com rela??o ao desenvolvimento das plantas, nos tratamentos com esp?cies de fungos micorr?zicos arbusculares inoculadas em plantas de bananeiras n?o houve diferen?a significativa. Por?m o teor de f?sforo foliar analisado aumentou significativamente no tratamento com o fungo Scutellospora calospora, e nos teores foliares de c?lcio e magn?sio para os tratamentos com os fungos: S. calospora, Entrhopospora colombiana e S. calospora+Glomus clarum. Os FMAs reduziram a popula??o do nemat?ide R. similis nas ra?zes das plantas de bananeira em casa de vegeta??o, sendo que S. calospora e G. clarum foram as mais eficientes. Na macrofauna do solo os resultados indicaram uma redu??o no sistema org?nico com bananeira, apresentando menor densidade e menor riqueza de grupos taxon?micos quando comparado com o sistema convencional. Os grupos decompositores e predadores apresentaram no ver?o a maior diversidade e densidade indicando uma melhor qualidade do solo no sistema com cultivo org?nico.
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Silveira, Raniere Fagundes de Melo. "Atividades biol?gicas de xilana de sabugo de milho." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12555.
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Previous issue date: 2010-02-25Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
The corn cob is an agricultural by-product still little used, this in part due to the low knowledge of the biotechnological potential of their molecules. Xylan from corn cobs (XSM) is a polysaccharide present in greater quantity in the structure of plant and its biotechnology potential is little known. This study aimed to the extraction, chemical characterization and evaluation of biological activities of xylan from corn cobs. To this end, corncobs were cleaned, cut, dried and crushed, resulting in flour. This was subjected to a methodology that combines the use of alkaline conditions with waves of ultrasound. After methanol precipitation, centrifugation and drying was obtained a yield of 40% (g/g flour). Chemical analysis indicated a high percentage of polysaccharides in the sample (60%) and low contamination by protein (0.4%) and phenolic compounds (> 0.01%). Analysis of monosaccharide composition indicated the presence of xylose:glucose:arabinose:galactose:mannose:glucuronic acid in a molar ratio 50:20:15:10:2.5:2.5. The presence of xylan in the sample was confirmed by nuclear magnetic resonance (?H and ??C) and infrared spectroscopy (IR). Tests were conducted to evaluate the antioxidant potential of XSM. This showed a total antioxidant capacity of 48.45 EAA/g sample. However, did not show scavenging activity of superoxide and hydroxyl radical and also reducing power. But, showing a high capacity chelating iron ions with 70% with about 2 mg/mL. The ability to XSM to influence cell proliferation in culture was also evaluated. This polymer did not influence the proliferation of normal fibroblast cells (3T3), however, decreased the rate of proliferation of tumor cells (HeLa) in a dose-dependent, reaching an inhibition of about 50% with a concentration around 2 mg/mL. Analyzing proteins related to cell death, by immunoblotting, XSM increases the amount of Bax, Bcl-2 decrease, increase cytochrome c and AIF, and reduce pro-caspase-3, indicating the induction of cell death induced apoptosis dependent and independent of caspase. XSM did not show anticoagulant activity in the PT test. However, the test of activated partial thromboplastin time (aPTT), XSM increased clotting time at about 5 times with 600 ?g of sample compared with the negative control. The presence of sulfate on the XSM was discarded by agarose gel electrophoresis and IR. After carboxyl-reduction of XSM the anticoagulant activity decreased dramatically. The data of this study demonstrate that XSM has potential as antioxidant, antiproliferative and anticoagulant compound. Future studies to characterize these activities of XSM will help to increase knowledge about this molecule extracted from corn and allow their use in functional foods, pharmaceuticals and chemical industries.
O sabugo de milho ? um subproduto agr?cola ainda pouco utilizado, isto se deve em parte ao baixo conhecimento do potencial biotecnol?gico de suas biomol?culas. Xilana de sabugo de milho (XSM) ? um polissacar?deo presente em maior quantidade na estrutura do vegetal e seu potencial biotecnol?gico ? pouco conhecido. Este trabalho teve como objetivo a extra??o, caracteriza??o qu?mica e avalia??o de atividades biol?gicas de XSM. Sabugos de milho foram limpos, cortados, desidratados e triturados, dando origem a uma farinha. Esta foi submetida a uma metodologia que combina o uso de meio alcalino com ondas de ultra-som. Ap?s precipita??o metan?lica, centrifuga??o e secagem obteve-se um rendimento de 40% (g/g de farinha). An?lises qu?micas indicaram um alto percentual de polissacar?deos na amostra (60%) e baixa contamina??o por prote?nas (0.4%) e compostos fen?licos (>0.01%). An?lises da composi??o monossacar?dica por cromatografia em papel e por cromatografia l?quida de alta performance (CLAE) indicaram a presen?a de xilose:glicose:arabinose:galactose:manose:?cido glucur?nico em uma propor??o molar de 50:20:15:10:2,5:2,5. A presen?a de xilana na amostra foi confirmada por resson?ncia magn?tica nuclear (13C e 1H) e por espectroscopia de infravermelho (IR). Testes foram realizados para avalia??o do potencial antioxidante de XSM. Esta mostrou uma capacidade antioxidante total de 48.45 EAA/g de amostra. Contudo, a mesma n?o mostrou atividade sequestradora de super?xido, radical hidroxila bem como poder redutor. Em contra partida, apresentou 70% de atividade quelante de ?ons de ferro na concentra??o de 2 mg/mL. A capacidade de XSM em influenciar a prolifera??o celular em cultura tamb?m foi avaliada. Este polissacar?deo n?o influenciou a prolifera??o de c?lulas fibrobl?sticas normais (3T3), entretanto, diminuiu a taxa de prolifera??o de c?lulas tumorais (HeLa) de maneira dose-dependente, chegando a uma inibi??o de aproximadamente 50% com concentra??o em torno de 2 mg/mL. Analisando prote?nas relacionadas ? morte celular, atrav?s de immunoblotting, XSM aumenta a quantidade de Bax, citocromo c e AIF e diminui Bcl-2 e procaspase- 3, indicando a indu??o de morte celular por apoptose dependente e independente de caspase. XSM n?o apresentou atividade anticoagulante pelo teste de PT. Todavia, no teste de tempo de tromboplastina parcial ativada (aPTT), XSM aumentou o tempo de coagula??o em cerca de 5 vezes utilizando 600 ?g de amostra, quando comparadas com o controle negativo. A presen?a de sulfato ligado a XSM foi descartada por eletroforese em gel de agarose e por IR. Ap?s carboxirredu??o de XSM a atividade anticoagulante diminuiu drasticamente. Os dados deste trabalho demonstram que XSM apresenta potencial como composto antioxidante, antiproliferativo e anticoagulante. Estudos futuros de caracteriza??o dessas atividades do XSM contribuir?o para aumentar o conhecimento sobre esta mol?cula extra?da de milho e permitir?o a sua utiliza??o em alimentos funcionais, produtos farmac?uticos e ind?strias qu?micas.
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Frizzo, Matias Nunes. "Avalia??o das bases biol?gicas e sociais do temperamento." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2013. http://tede2.pucrs.br/tede2/handle/tede/5463.
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Previous issue date: 2013-02-08Temperament can be regarded as the basis of mood, behavior and personality. It has a strong biological basis, manifested early in the development of the individual, guiding the formation of habits and is relatively stable over time. Although it is known that there are environmental influences, the relationship of temperament with biological markers and social environment is not well defined. Evidence suggests that the temperament and personality traits predict psychiatric disorders and that most of them are recurrent and chronic. Thus, this study aims to investigate the biological and social basis of behavior and in animal models of traits to assess the relationship of temperament with hyperucemia and with self-report of having been bullied in humans. To study the neurobiological basis of this trait, we selected mice with high and low exploration of a central object in an open field. Out of one hundred mice tested, the ten mice with higher (HE) and lower exploratory (LE) activity were evaluated with gene expression (Genechip Mouse Gene 1.0 ST Array Affymetrix) in the striatum and frontal cortex. The results showed 118 and 86 differentially expressed genes (DEGs) in the striatum and frontal cortex, respectively. Through analysis of DEGs biological processes were significantly more enriched in nervous system were development and function and cell-to-cell signaling, particularly in the striatum. These results suggest the involvement of translational and post-translational processes as well as striatal synaptic elements in the trait differences of exploratory behavior. Human studies were conducted with the data collected in a large web-survey on psychological and psychiatric measures (BRAINSTEP). In the study of biological basis of behavior we analyzed temperament in 7.155 males (5.1% hyperuricemic) and 25.225 women (1.8% hyperuricemic). Hyperuricemic subjects scored higher in anger and lower in inhibition and control, but hyperuricemic women also showed a higher emotional sensitivity and a lower degree of volition and coping. Subjects with hyperuricemia present more more externalizing and unstable emotional traits and affective temperaments In the study of the social bases of temperament assessed bullying during childhood and adolescence, through a question on time of exposure to bullying (none, <1 year, 1-3 years and> 3 years). Emotional traits and affective temperaments were evaluated with The Affective and Emotional Composite Temperament Scale (AFECTS). About half of the sample reported exposure to bullying and 10% reported being victimized by peers for longer than 3 years. Longer exposure to bullying was associated with lower Volition, Coping and Control. Bullying victimization was also associated with a much lower proportion of euthymic and hyperthymic types in both genders, which was compensated by an increase mainly in the proportion of depressive, cyclothymic and volatile types. Being bullied was associated with a broad and profound impact on emotional and cognitive domains in all dimensions of emotional traits, and with internalized and unstable affective temperaments. These results, taken together, show the importance of social factors and serum markers, as well as genetic markers of temperament.
O temperamento pode ser considerado como a base do humor, do comportamento e da personalidade, tem uma base biol?gica forte, manifesta-se cedo no desenvolvimento do indiv?duo, norteia a forma??o dos h?bitos sendo relativamente est?vel no decorrer do tempo. Apesar de se saber que h? influ?ncias do meio, n?o est? bem definida a rela??o entre temperamento e o meio social. Evid?ncias sugerem que o temperamento e os tra?os de personalidade predisp?em aos transtornos psiqui?tricos e que a maioria deles ? recorrente e cr?nico. Dessa forma, o presente estudo tem como objetivo investigar as bases biol?gicas e sociais do temperamento em modelos animais de temperamento e avaliar a rela??o do temperamento com hiperuricemia (eleva??o dos n?veis s?ricos de ?cido ?rico) e com o autorrelato de ter sido v?tima de bullying em humanos. Na avalia??o das bases neurobiol?gicas do temperamento foram usados modelos animais, no qual foram selecionados camundongos com alta e baixa explora??o em um teste campo aberto. Foram testados cem camundongos, e posteriormente selecionados os dez camundongos mais exploradores (HE) e os dez menos exploradores (LE), cujo mRNA de c?rtex frontal e estriado foi coletado para posteriormente ser avaliado atrav?s de chips para avalia??o da express?o g?nica (Genechip Mouse Gene 1.0 ST Array - Affymetrix). Os resultados mostraram 86 e 118 genes expressos diferencialmente (DEGS) no estriado e no c?rtex frontal, respectivamente. Atrav?s da an?lise dos DEGs os processos biol?gicos mais significativamente enriquecidos foram o do desenvolvimento do sistema nervoso e da fun??o e sinaliza??o celular, especialmente no estriado, numa compara??o entre animas HE com LE. Estes resultados sugerem o envolvimento de processos de transla??o e p?s-tradu??o, assim como os elementos sin?pticos do estriado nas diferen?as de caracter?sticas de comportamento explorat?rio. Nos estudos em humanos, os dados foram coletados em um grande levantamento via Web atrav?s do Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP). No estudo de bases biol?gicas do temperamento em humanos, analisamos o temperamento em 7.155 homens (5,1% hiperuric?micos) e 22.225 mulheres (1,8% hiperuric?micas). Indiv?duos hiperuric?micos apresentaram escores mais elevados em raiva e inferiores na inibi??o e controle, j? as mulheres hiperuric?micas tamb?m mostram uma maior sensibilidade emocional e um menor grau de vontade e de enfrentamento. Os resultados demonstraram que indiv?duos com hiperuricemia t?m mais tra?os emocionais e temperamentos afetivos externalizados e inst?veis. No estudo sobre as bases sociais do temperamento avaliamos o bullying durante a inf?ncia e adolesc?ncia, atrav?s de uma pergunta sobre tempo de exposi??o ao bullying (nenhum, <1 ano, 1 a 3 anos e > 3 anos). Tra?os emocionais e temperamentos afetivos foram avaliados com a Escala de Temperamento Afetivo e Emocional (AFECTS). Cerca de metade da amostra relatou exposi??o ao bullying e 10% relataram ter sido v?timas por mais de 3 anos. Vitimas de bullying tamb?m apresentam uma propor??o muito menor de temperamentos eut?micos e hipert?micos em ambos os sexos, o que foi compensado por um aumento, principalmente, na propor??o de tra?os depressivos, ciclot?micos e vol?til. Sofrer bullying foi associado com um impacto amplo e profundo sobre os dom?nios cognitivos e emocionais em todas as dimens?es de tra?os emocionais, e com temperamento afetivo internalizado e inst?vel. Esses resultados, em conjunto, mostram a import?ncia de poss?veis marcadores s?ricos (?cido ?rico) e fatores gen?ticos e sociais sobre os tra?os de temperamento.
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Melo, Luciana Fentanes Moura de. "Extratos de Coccoloba alnifolia Casar e suas atividades biol?gicas." PROGRAMA DE P?S-GRADUA??O EM BIOQU?MICA, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/24994.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
O uso de plantas medicinais ? uma pr?tica comum da humanidade desde a antiguidade. Tal conhecimento baseado na experi?ncia tem sido repassado por muitas comunidades e grupos ?tnicos, e serve como ponto de partida para estudos bioqu?micos e farmacol?gicos dos princ?pios ativos presentes nas plantas. Para isto, neste trabalho foram avaliados o potencial antioxidante e tamb?m biol?gico, utilizando sistemas in vitro e in vivo dos diferentes extratos obtidos de folhas da planta Coccoloba alnifolia. Foram obtidos inicialmente seis extratos: hexano (EH), clorof?rmio (EC), etan?lico (EE), metan?lico (EM), ?gua final (EAF) e aquoso (EA) a partir das folhas frescas da planta. Posteriormente, foram avaliados o teor de a??car, prote?nas e compostos fen?licos. Os resultados obtidos na triagem fitoqu?mica sugerem a presen?a de fen?is, flavonoides, saponinas, n?cleo triterp?nicos e esteroidais e n?cleo esteroidal insaturado, j? com a metodologia de cromatografia em camada delgada (CCD), foi observado uma abund?ncia de flavonoides. Foram realizados quatro ensaios: Teste do Poder Redutor, Quela??o de ?ons Metais, Quela??o de Cobre e Atividade Sequestradora de Radical Hidroxila. Estes ensaios permitiram verificar que os extratos apresentaram atividade antioxidante nas concentra??es avaliadas de 100, 250 e 500 ?g/mL. Foi verificado principalmente para os extratos EE, EM e EA as atividades antioxidante nos ensaios poder redutor e sequestro do radical hidroxila. A correla??o de Pearson mostrou que estes dados est?o associados aos compostos fen?licos e a??cares. E com o modelo das linhagens celulares foi observado que a maioria dos extratos avaliados neste trabalho n?o mostrou-se citot?xico para as linhagens celulares. Os extratos tamb?m n?o inibiram o crescimento da levedura Candida parapsilosis. Os extratos obtidos da folha de C. alnifolia apresenta um potencial antioxidante interessante, e os resultados obtidos tanto nos modelos in vitro, como as linhagens celulares, refor?am que s?o necess?rios mais estudos para compreender o potencial destes extratos in vivo e identificar quais s?o as biomol?culas associadas com estas atividades e seus respectivos potenciais biotecnol?gicos.
The use of medicinal plants has been a common practice in folk medicine. This knowledge has been based on the experience that it has been passed though many generations. However, many times this knowledge do not have any scientific base. The molecules responsive for these activities are the secondary metabolic produce as a response to environmental conditions (biotic or abiotic stress). The Mata atl?ntica biome has a rich flora, which needs to be studied for its biological activities, and its potential to identify new biomolecules. In order to do this, six extracts (HE, CE, EE, ME, WEE e WE) were obtained from Coccoloba alnifolia leaves and then it was evaluated the antioxidant and the biological potential using different in vitro and in vivo systems. First, it was measured the sugar content, proteins and phenolic compounds. Based on these results, qualitative experiments were carried out to determine the secondary metabolites present in these extracts. It was detected the presence of phenols, flavonoids, saponins, triterpenic, and steroidal nuclei and unsaturated steroidal nuclei. After that, it was evaluated the antioxidant potential by four in vitro assay: Redution Power test, Metal Ion Chelation, Copper Chelation and Hydroxyl Radical Scavenging Activity. These assays allowed us verify that the extracts presented antioxidant activity at extract concentrations: 100, 250 and 500 ?g/mL. It was observed the ethanolic, methanolic and aqueous extracts had activity in reducing power and scavenging of the hydroxyl radical. The Pearson?s correlation showed that these results may be associated to the presence of phenolic compounds and sugars. The third in vitro model used in this work was cell culture. When it was used the 3T3 lineage it was observed that these extracts were not cytotoxic. However, it was not observed any antiproliferative activity in tumor cell lineages. In sumary, the data obtained here showed that using in vitro assays that these extracts in special ethanolic and aqueous had an interesting antioxidant potential and it will be important to go further in this research.
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Alves, Jovelina Samara Ferreira. "Estudo qu?mico e biol?gico de Genipa americana L. (Jenipapo)." PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMAC?UTICAS, 2014. https://repositorio.ufrn.br/jspui/handle/123456789/22388.
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Genipa americana Linnaeus (Rubiaceae), ocorre amplamente na regi?oNordeste e em outras regi?es do Brasil, como tamb?m em outros pa?ses. Sob oponto de vista medicinal, a esp?cie ? usada pela popula??o para diferentes finscomo: cat?rtico, antidiarr?ico, antigonorr?ico, antiulceroso, analg?sico, emcasos de s?filis, anemia, icter?cia, asma, dentre outros. Devido ao reconhecidouso popular e a escassez de estudos qu?micos e farmacol?gicos, o principalobjetivo deste estudo foi caracterizar os marcadores e/ou compostos ativos eavaliar atividades farmacol?gicas da esp?cie. O estudo iniciou-se com a coletade folhas, frutos maduros e verdes nas media??es da Praia de Barreta (N?siaFloresta-RN), dos quais as folhas foram submetidas ? secagem e moagem.Posteriormente, foram preparados os extratos hidroetan?licos (EH) das folhas,pericarpo e endocarpo dos frutos e fracionados com solventes org?nicos comordem de polaridade crescente (?ter de petr?leo, diclorometano, acetato deetila, e n-butanol). Para an?lise qualitativa do extrato das folhas e frutos foramutilizadas as t?cnicas de Cromatografia em Camada Delgada (CCD) eCromatografia L?quida de Alta Efici?ncia (CLAE). Diversos procedimentoscromatogr?ficos (Cromatografia L?quida a V?cuo, Cromatografia em ColunaCl?ssica e Cromatografia L?quida de Alta Efici?ncia Semi-preparativa) foramutilizados para o isolamento de compostos qu?micos. Adicionalmente,realizaram-se ensaios de atividade anti-inflamat?ria do extrato das folhas, nomodelo de peritonite aguda em camundongos e o ensaio de atividadeantimicrobiana, pelo m?todo de difus?o em disco, com extrato do endocarpo edas folhas de G. americana. Foi observado por CCD e CLAE a presen?a deflavonoides e iridoides no extrato das folhas e iridoides nos extratos dos dopericarpo e endocarpo dos frutos. A partir do extrato da folha foram isolados ecaracterizados dois iridoides, denominados tetrahidro-7-(hidroximetil)1-metoxiciclo-pentapiran-4-carbalde?do, in?dito para a esp?cie e o GF2,provavelmente in?dito na literatura, os carboidratos manitol e GF7 e cincoflavonoides GF4, GF5, GF6, GF8 e GF9. Os seis ?ltimos compostos est?o emfase de elucida??o estrutural. A partir do extrato do endocarpo foram isoladosos compostos GE1, GE2, GE3, GE4 e GE5, os quais est?o em fase deelucida??o estrutural. O extrato das folhas e do endocarpo de G. americanan?o apresentaram atividade antimicrobiana promissora. O extrato das folhasapresentou atividade anti-inflamat?ria nas doses 50, 100, 200 e 300 mg/Kg,observada por meio da inibi??o da migra??o de leuc?citos para o local dainflama??o. T?cnicas de elucida??o estrutural est?o sendo realizadas paraelucida??o de todos os compostos isolados de G. americana. O estudofitoqu?mico e de atividades farmacol?igicas desenvolvidos com as folhas daesp?cie s?o resultados inovadores, pois at? o momento era registrada apresen?a de irirdoides, monoterpenos, ?cidos carbox?licos apenas nos frutos daG. americana. Para as folhas da esp?cie n?o h? relatos na literatura sobre apresen?a de irid?ides e flavonoides.
Genipa americana Linnaeus (Rubiaceae), ocorre amplamente na regi?oNordeste e em outras regi?es do Brasil, como tamb?m em outros pa?ses. Sob oponto de vista medicinal, a esp?cie ? usada pela popula??o para diferentes finscomo: cat?rtico, antidiarr?ico, antigonorr?ico, antiulceroso, analg?sico, emcasos de s?filis, anemia, icter?cia, asma, dentre outros. Devido ao reconhecidouso popular e a escassez de estudos qu?micos e farmacol?gicos, o principalobjetivo deste estudo foi caracterizar os marcadores e/ou compostos ativos eavaliar atividades farmacol?gicas da esp?cie. O estudo iniciou-se com a coletade folhas, frutos maduros e verdes nas media??es da Praia de Barreta (N?siaFloresta-RN), dos quais as folhas foram submetidas ? secagem e moagem.Posteriormente, foram preparados os extratos hidroetan?licos (EH) das folhas,pericarpo e endocarpo dos frutos e fracionados com solventes org?nicos comordem de polaridade crescente (?ter de petr?leo, diclorometano, acetato deetila, e n-butanol). Para an?lise qualitativa do extrato das folhas e frutos foramutilizadas as t?cnicas de Cromatografia em Camada Delgada (CCD) eCromatografia L?quida de Alta Efici?ncia (CLAE). Diversos procedimentoscromatogr?ficos (Cromatografia L?quida a V?cuo, Cromatografia em ColunaCl?ssica e Cromatografia L?quida de Alta Efici?ncia Semi-preparativa) foramutilizados para o isolamento de compostos qu?micos. Adicionalmente,realizaram-se ensaios de atividade anti-inflamat?ria do extrato das folhas, nomodelo de peritonite aguda em camundongos e o ensaio de atividadeantimicrobiana, pelo m?todo de difus?o em disco, com extrato do endocarpo edas folhas de G. americana. Foi observado por CCD e CLAE a presen?a deflavonoides e iridoides no extrato das folhas e iridoides nos extratos dos dopericarpo e endocarpo dos frutos. A partir do extrato da folha foram isolados ecaracterizados dois iridoides, denominados tetrahidro-7-(hidroximetil)1-metoxiciclo-pentapiran-4-carbalde?do, in?dito para a esp?cie e o GF2,provavelmente in?dito na literatura, os carboidratos manitol e GF7 e cincoflavonoides GF4, GF5, GF6, GF8 e GF9. Os seis ?ltimos compostos est?o emfase de elucida??o estrutural. A partir do extrato do endocarpo foram isoladosos compostos GE1, GE2, GE3, GE4 e GE5, os quais est?o em fase deelucida??o estrutural. O extrato das folhas e do endocarpo de G. americanan?o apresentaram atividade antimicrobiana promissora. O extrato das folhasapresentou atividade anti-inflamat?ria nas doses 50, 100, 200 e 300 mg/Kg,observada por meio da inibi??o da migra??o de leuc?citos para o local dainflama??o. T?cnicas de elucida??o estrutural est?o sendo realizadas paraelucida??o de todos os compostos isolados de G. americana. O estudofitoqu?mico e de atividades farmacol?igicas desenvolvidos com as folhas daesp?cie s?o resultados inovadores, pois at? o momento era registrada apresen?a de irirdoides, monoterpenos, ?cidos carbox?licos apenas nos frutos daG. americana. Para as folhas da esp?cie n?o h? relatos na literatura sobre apresen?a de irid?ides e flavonoides.
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Nogueira, Lilian Capanema. "Resist?ncia adesiva ? microtra??o de restaura??es biol?gicas posteriores." UFVJM, 2014. http://acervo.ufvjm.edu.br:8080/jspui/handle/1/299.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)
A ?Restaura??o Biol?gica? ? uma t?cnica que pode oferecer uma excelente biocompatibilidade, desgaste fisiol?gico e mant?m as caracter?sticas est?ticas e funcionais da estrutura do dente tais como brilho de superf?cie, textura, dureza, tamanho, forma, cor e resili?ncia. O objetivo do presente estudo foi comparar pelo ensaio de microtra??o a resist?ncia ? ades?o de restaura??es biol?gicas ap?s cimenta??o no substrato dentin?rio em compara??o as convencionais restaura??es est?ticas cer?micas e analisar suas ?reas de fratura. Foram selecionados vinte e quatro terceiros molares humanos h?gidos, rec?m-extra?dos, que tiveram suas por??es coron?rias seccionadas em dentina e aleatoriamente divididos em dois grupos (n=12), grupo controle (Restaura??es Cer?micas IPS e.max ZirPress) e grupo experimental (Restaura??es Biol?gicas). Para confec??o das restaura??es biol?gicas, discos de dentina foram seccionados com espessura de 2,0 mm cada. Pastilhas de cer?mica foram confeccionadas com as mesmas dimens?es dos discos de dentina. As restaura??es foram cimentadas com cimento resinoso Rely X ARC e ap?s 24 horas submetidos a 10.000 ciclos de termociclagem (5-55?C). Os dentes foram seccionados perpendicularmente ? interface de uni?o, gerando palitos de 1 mm2 e submetidos a ensaio de microtra??o com velocidade de 0,5 mm/min, utilizando uma c?lula de carga de 5Kg. Foi realizada an?lise do padr?o de fratura em lupa estereosc?pica com o aumento de 40x. Esp?cimes representativos foram caracterizados por MEV/EDS para an?lise da morfologia geral e composi??o qu?mica elementar quantitativa dos materiais. Esp?cimes representativos de cada grupo foram submetidas ao protocolo de nanoinfiltra??o com AgNO3 e analisados em MEV. Os dados foram analisados pelo teste t de Student para esp?cimes independentes (p ? 0.05) e do qui-quadrado. N?o foi observada diferen?a estat?stica significativa em rela??o ? resist?ncia ? ades?o. Houve diferen?a significativa (p=0,015) quanto ao tipo de fratura, com 75% de fraturas adesivas para o grupo experimental. As restaura??es biol?gicas apresentaram comportamento semelhante em termos de resist?ncia ? ades?o, quando comparadas ?s restaura??es cer?micas, podendo vir a ser consideradas alternativas para o restabelecimento est?tico-funcional de dentes posteriores.
Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014.
ABSTRACT ?Biological restoration? offers excellent biocompatibility and maintains the esthetic and functional characteristics of the tooth, such as physiological wear, surface shine, texture, hardness, size, shape, color and resilience. The aim of the present study was to evaluate the bond strength of biological restorations on dentin in comparison to conventional porcelain restorations through a microtraction test and characterize areas of fracture. The crowns of 24 recently extracted sound human third molars were planed to the dentin and randomly divided into a control group (n = 12; porcelain restorations ? IPS e.max ZirPress) and experimental group (n = 12, biological restorations). Biological restorations were made from fragments of the teeth cut to a thickness of 2.0 mm. Porcelain crowns were made with the same dimensions as the biological fragments. All restorations were cemented with Rely X ARC resin and, after 24 hours, submitted to 10,000 thermal cycles (5 to 55 ?C). The teeth were sectioned perpendicularly to the interface of the union for the obtainment of samples measuring 1 mm2, which were submitted to microtraction using the EZ Test - L universal testing machine operating at 0.5 mm/min with a 5 Kg cell load. Standard fracture analysis was performed with a stereomicroscopic magnifying glass (magnification: 40 x). Representative samples were characterized by scanning electron microscopy (SEM) for the analysis of general morphology and the quantitative element composition of the materials. Additional representative samples from each group were submitted to nano-injection with AgNO3 and analyzed using SEM. Data analysis involved the Student?s t-test for independent samples and the chi-squared test (p ? 0.05). No significant difference in bond strength was found, but a significant difference was found regarding the type of fracture (p = 0.015), with an adhesive fracture rate of 75% in the experimental group. Biological restorations demonstrate similar behavior to that found in porcelain restorations with regard to bond strength and constitute a viable option for the reestablishment of function and esthetics on posterior teeth.
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Barroso, Poliana Ribeiro. "Fitoqu?mica e atividades biol?gicas de Miconia ferruginata DC. (Melastomataceae)." UFVJM, 2015. http://acervo.ufvjm.edu.br:8080/jspui/handle/1/759.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)
Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)
As plantas medicinais s?o fontes promissoras de novas drogas, em que a regi?o do Cerrado se destaca pela sua vasta biodiversidade. Dentre as plantas medicinais utilizadas nesta regi?o se encontra a esp?cie Miconia ferruginata DC. que ? conhecida como pixirica-do-campo ou babaten?o. Esta esp?cie ? utilizada no tratamento de doen?as de pele, e outras de origens inflamat?rias, parasit?rias e infecciosas, por?m os estudos qu?micos s?o escassos. Assim, os objetivos deste trabalho foram avaliar o perfil qu?mico e o potencial biol?gico da M. ferruginata (Melastomataceae). A esp?cie foi coletada no munic?pio de Diamantina, MG do qual foram preparados os extratos aquosos e etan?licos das folhas/flores e do caule. Por meio da triagem fitoqu?mica e das an?lises de CLAE-DAD-EM obteve-se um perfil qu?mico rico em compostos fen?licos. Foi poss?vel a identifica??o da presen?a de taninos, ?cidos fen?licos, flavonoides, e derivados glicosilados da quercetina. Pela an?lise dos constituintes vol?teis por CG-EM foi poss?vel identificar a presen?a de quatorze compostos, sendo eles pertencentes as classes dos sesquiterpenos, hidrocarbonetos, monoterpenos, fenilpropanoides e alco?is. No qual os sesquiterpenos ?-cariofileno e ?-humuleno foram os compostos majorit?rios, os quais s?o associados na literatura a diversas atividades biol?gicas, em especial a a??es anti-inflamat?rias, antif?ngicas e antitumorais. A an?lise das fra??es por CG-EM e CLAE-DAD foi poss?vel identificar catequinas, ?cido g?lico e flavon?is nos extratos aquosos e ?steres graxos e as subclasses das flavonas e flavon?is nos extratos etan?licos. Nas avalia??es biol?gicas os extratos etan?licos e aquosos apresentaram baixa toxicidade em c?lulas de mam?feros, em que a concentra??o selecionada para a avalia??o das demais atividades biol?gicas foi de at? 500 ?g/mL. Para a atividade antitumoral, os extratos apresentaram um grande potencial concentra??o dependente, com valores de IC50 variando de 56,44 a 180,4 ?g/mL. Bem como o tempo de exposi??o aumentou a pot?ncia de todos os extratos. Tamb?m foi observado que os extratos aquosos promoveram a inibi??o da prolifera??o de linf?citos estimulados por mit?genos, apresentando uma efic?cia em rela??o ? dexametasona, de 39,94% para o extrato das folhas a 45 ?g/mL, e de 57,3%, 137,4% e 251,8% para os extratos do caule a 15, 20 e 30 ?g/mL, respectivamente. Este efeito proliferativo pode estar relacionado ao potencial anti-inflamat?rio da M. ferruginata, relatada na medicina popular. Possivelmente, as atividades biol?gicas est?o relacionadas ao rico perfil qu?mico desta esp?cie, principalmente em compostos fen?licos. Para as atividades antimicrobianas, tripanocida 9 e leishmanicida n?o foram observadas a inibi??o do crescimento ou toxicidade frentes as cepas avaliadas. Desta forma este trabalho contribuiu para o conhecimento qu?mico e biol?gico da M. ferruginata. Por?m ensaios futuros utilizando as fra??es e subst?ncias isoladas, se fazem necess?rios para fortalecer os dados aqui apresentados e para demonstrar quais os mecanismos moleculares envolvidos nas atividades biol?gicas investigadas.
Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2015.
ABSTRACT Medicinal plants are reassuring sources of new drugs, in which the Cerrado region stands out for its broad biodiversity. Among the medicinal plants used in this same region is the species Miconia ferruginata DC. which is also known as pixirica-docampo or babaten?o. This species is used in the treatment of skin diseases, and other inflammatory, infectious and parasitic sources, despite the chemical studies about it are lacking. Therefore, the objectives of this study were to evaluate the chemical profile and biological potential of the M. ferruginata (Melastomataceae).The species was collected in Diamantina, MG, in which it was prepared for water and ethanol extraction of the leaves/flowers and stem. Through phytochemical screening and analysis of HPLC-MSDAD, we obtained a rich chemical profile in phenolic compounds. The identification of tannins, phenolic acids, flavonoids, glycosides of quercetin and derivativeshas been detected. For the analysis of volatile constituents by GC-MS, it was possible to identify the presence of fourteen compounds, namely belonging classes of sesquiterpenes, hydrocarbons, monoterpenes, phenylpropanoids and alcohols. For that,? and?- caryophyllene, humulenesesquiterpenes were the main components, which are associated in the literature several biological activities, especially anti-inflammatory, antifungal and antitumor activities.In the analysis of the fractions by GC-MS and HPLC-DAD, we identified catechins, gallic acid and flavonols in aqueous extracts,including fatty esters and subclass of flavones and flavonols in ethanol extracts. Within the biological evaluations, aqueous and ethanolic extracts showed low toxicity to mammalian cells, wherein the concentration selected for analysis of other biological activities was up to 500 ?g/mL. For antitumor activity, the extracts showed a great potential concentration-dependent, with IC50 values ranging from 56.44 to 180.4 ?g/mL. Just as the exposure time increased the potency of all extracts, it was also observed that aqueous extracts promoted inhibition of the proliferation of mitogen-stimulated lymphocytes, showing a efficacy when compared to dexamethasone, 39.94% for the extract from the leaves of 45 ?g/mL, and 57.3%, 137.4% and 251.8% for the extracts of stem of 15.20 and 30 ?g/mL, respectively. This proliferative effect may be related to the anti-inflammatory potential of M. ferruginata, reported in folk medicine. Possibly, the biological activities are related to the rich chemical profile of this species, mainly in phenolic compounds. For the antimicrobial, trypanocidal and leishmanicidal activities, we have not observed growth inhibition or toxicity fronts of the evaluated strains. Thus 11 this work contributed to the chemical and biological knowledge of M. ferruginata. Nevertheless, future trials using isolated fractions and substances are needed to strengthen the data presented here and to demonstrate the molecular mechanisms involved in the biological activities investigated. It is likely that the biological activities are related to the rich chemical profile of this species, mainly regarding phenolic compounds. For antimicrobial activity, trypanocidal and leishmanicidal, it was not observed growth inhibition or toxicity regarding the evaluated strains. Thus, this work contributed to the chemical and biological knowledge of the M. ferruginata. However, future trials using isolated fractions and substances are needed to strengthen the data presented here and to demonstrate the molecular mechanisms involved in the biological activities hereby investigated.
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Wakamatsu, Yuko. "Preface to Volume 11, the last volume of Fish Biol. J. MEDAKA." Laboratory of Freshwater Fish Stocks Bioscience and Biotechnology Center Nagoya University, 2007. http://hdl.handle.net/2237/13828.
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Zampirolli, Leticia Silotti. "Dialquilfosforilidrazonas derivadas de isatinas N - substitu?das com potencial atividade biol?gica." Universidade Federal Rural do Rio de Janeiro, 2009. https://tede.ufrrj.br/jspui/handle/jspui/2077.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES, Brasil.
A series of new dialkylphosphorylhydrazones (phosphorohydrazidic acid, N?-[1,2-dihydro-2- oxo-(R1)-3H-indole-3-iliden]- dialkyl esters was synthesized and characterized by IR, 1H, 13C and 31P NMR and mass spectroscopy. These dialkylphosphorylhydrazones were synthesized in three steps. The first step involved the synthesis of different dialkylphosphites which are obtained by the reaction of PCl3 with three mols of the corresponding alcohols. The second step consisted of the reaction between the dialkylphosphites and hydrazine in a two phase system, leading to the formation of the dialkylphosphorylhydrazines. Finally, the last step was the condensation of these dialkylphosphorylhydrazines with different N-substituted isatins. The analysis of the 1H, 13C and 31P NMR spectra showed the existence of the two possible diastereoisomers E and Z for compounds 1, 2, 6, 10 and 12, while for the remaining compounds only the Z isomer is present. Ten of these compounds were preliminarily tested for their inhibition potential against two protozoa (Trypanosoma cruzi and Leishmania amazonensis). All compounds tested showed cell proliferation inhibition of 98% at 50 ?M for Leishmania amazonensis, whereas for T. cruzi, inhibition of epimastigote cell proliferation was found to be higher than 75% for all compounds tested except 6, which showed a 59% inhibition. These ten compounds were also evaluated against Plasmodium falciparum, affording inhibitions higher than 90% for a 1mM concentration. These compounds were also investigated for their fungicidal activity against phytopatogenic Rhizoctonia solani and Fusarium oxysporum. Compounds 9 and 11 showed a miscelial growth inhibition of 58% for Rhizoctonia solani while compound 12 afforde a 72% inhibition. Compounds 1, 2, 11 and 12 gave Fusarium oxysporum inhibition higher than 52%. Finally, the compounds synthesized were also evaluated for their inhibitory potential against lettuce seed germination and it was observed that the same compounds which showed fungicidal activity were not able to inhibit seed germination.
Uma s?rie de 16 dialquilfosforilidrazonas (?cido fosforoidraz?dico, N? -[1,2-diidro-2-oxo-(R1)- 3H- indol-3-ilideno] -, ?ster de dialquila), sendo todas in?ditas, foram sintetizadas e caracterizadas pelas t?cnicas de espectrometria de IV, RMN de 1H, RMN de 13C, RMN de 31P e massas. As novas dialquilfosforilidrazonas foram sintetizadas em tr?s etapas de rea??o. A primeira etapa consistiu na s?ntese de diferentes fosfitos de dialquila que foram obtidos atrav?s da rea??o do tricloreto de f?sforo (PCl3) com tr?s mols do ?lcool correspondente. Na segunda etapa, a rea??o dos fosfitos de dialquila com a hidrazina, em um sistema bif?sico, levou ? forma??o das dialquilfosforilidrazinas. A ?ltima etapa foi a condensa??o destas dialquilfosforilidrazinas com diferentes isatinas substitu?das. A an?lise dos espectros de RMN de 1H, RMN de 13C, RMN de 31P das dialquilfosforilidrazonas mostraram a coexist?ncia dos dois poss?veis diastereois?meros E e Z, para os compostos 1, 2, 6, 10 e 12, enquanto que para os compostos restantes observou-se apenas o diastereois?mero Z. Dos compostos sintetizados, dez foram avaliados preliminarmente quanto ao potencial inibit?rio de prolifera??o de dois protozo?rios (Trypanosoma cruzi e Leishmania amazonensis). Para Leishmania amazonensis todos os compostos testados apresentaram inibi??o da prolifera??o celular de 98 % a 50 ?M. Enquanto que para T.cruzi verificou-se inibi??o da prolifera??o celular de epimastigotas superior a 75% para todos compostos testados, a exce??o do composto (6) cuja inibi??o foi de 59 %. Esses dez compostos tamb?m foram avaliados frente ao protozo?rio Plasmodium falciparum apresentando inibi??o superior a 90 % para todos os compostos testados, a uma concentra??o de 1mM. Essas dialquilfosforilidrazonas tamb?m tiveram a a??o fungicida avaliada frente aos fungos fitopatog?nicos (Rhizoctonia solani e Fusarium oxysporum). Em Rhizoctonia solani os compostos (9) e (11) apresentaram inibi??o do crescimento miscelial de 58 %, j? o composto (12) apresentou inibi??o de 72%. Para o Fusarium oxysporum destacaram-se os compostos (1, 2, 11 e 12) com inibi??o superior a 52 %. Esses compostos tamb?m foram avaliados quanto ao potencial inibit?rio de germina??o em sementes de alface e verificouse que os mesmos compostos que apresentaram efeitos fungist?ticos, n?o inibiram a germina??o de sementes de alface.
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Mac?do, Marina de Oliveira Cardoso. "Modifica??o de membranas de quitosana por plasma para uso biol?gico." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12681.
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Previous issue date: 2009-04-30Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Chitosan membranes have been modified by plasma, utilizing the following gases: nitrogen (N2), methane (CH4), argon (Ar), oxygen (O2) and hydrogen. The modified membranes by plasma were compared to the unmodified ones. The membranes were characterized by absorption assay, contact angle, atomic force microscopy (AFM). Also, permeability assay of sodium sulfamerazine from such membranes were carried out. Through the absorption assay and contact angle it was possible to obtain information of the wettability of the membranes and what changes the plasma treatment can promote in relation to it. The plasma treatment using oxygen promoted increase of the wetability and swelling while the samples treated with methane decrease of the wetability and swelling. Through the Optical Emission Spectroscopy (OES) it was possible to identify which species were present in the plasma during the treatment. And through the AFM analysis it was possible to observe the changes nanotopography occurred on the surface of the samples. Permeability assay were archived for all treated membranes and compared to no treated ones. Due to that assay it was possible verify which the plasma treatment increased the permeability spectrum of the membranes which has varied from 1,4548 *10-5cm2.min-1 to 2,7713*10-5cm2.min-1. Chitosan membranes with permeability varied are importance in systems drug delivery, to liberate a wide variety of drugs
Membranas de quitosana foram modificadas por plasma, utilizando os seguintes gases: nitrog?nio (N2), metano (CH4), arg?nio (Ar), oxig?nio (O2) e hidrog?nio (H2). Membranas n?o tratadas foram utilizadas para compara??o com as tratadas. As amostras foram caracterizadas por ensaio de ganho de massa (capacidade de absor??o de ?gua), ?ngulo de contato, microscopia de for?a at?mica (MFA) e quanto ? sua permeabilidade em rela??o ao f?rmaco sulfamerazina de s?dio. Atrav?s dos ensaios de absor??o e ?ngulo de contato foi poss?vel obter informa??es sobre a molhabilidade das membranas e quais mudan?as o tratamento a plasma pode promover em rela??o ? molhabilidade. O tratamento por plasma utilizando o oxig?nio promoveu um aumento da hidrofilicidade e do ganho de massa enquanto as amostras tratadas com metano tiveram uma diminui??o da hidrofilicidade e do ganho de massa. Atrav?s da Espectroscopia de Emiss?o ?tica (EEO) identificaram-se quais esp?cies estavam presentes no plasma durante o tratamento, pois estas influenciam o grau de molhabilidade das amostras, tornando-as mais hidrof?licas ou hidrof?bicas atrav?s da inser??o de grupos funcionais. Nos resultados da MFA foi poss?vel observar as modifica??es nanotopogr?ficas ocorridas na superf?cie das amostras, como o aumento da rugosidade em amostras tratadas com hidrog?nio e a diminui??o dessa rugosidade nas amostras tratadas com arg?nio. Ensaios de permea??o foram realizados para todas as membranas tratadas e comparados com as membranas n?o tratadas. Atrav?s desse ensaio foi poss?vel verificar que os tratamentos a plasma ampliaram o espectro de permeabilidade das membranas que variou de 1,4548 *10-5cm2.min-1 a 2,7713*10-5cm2.min-1. As amostras tratadas com oxig?nio apresentaram a menor permeabilidade enquanto que a amostras tratada com arg?nio apresentaram a maior permeabilidade. A obten??o de membranas de quitosana com permeabilidade variada ? de grande import?ncia na tecnologia de libera??o de f?rmacos, pois as mesmas podem ser utilizadas nos mais diversos sistemas carreadores de f?rmacos. Liberando uma ampla variedade de f?rmacos e/ou agente bioativos
Books on the topic "(Biol.)"
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Zittlau, Jörg. Warum Robben kein Blau sehen und Elche ins Altersheim gehen: Pleiten und Pannen im Bauplan der Natur. Berlin: Ullstein, 2008.
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Hsü, Kenneth J. Die letzten Jahre der Dinosaurier: Meteoriteneinschlag, Massensterben und die Folgen für die Evolutionstheorie. Basel: Birkhäuser, 1990.
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Žeiviniece, Anna. Dr. habil. biol. Alfons Piterāns: Bibliogrāfiskais rādītājs. Rīga: LU Akadēmiskais apgāds, 2005.
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Trainor, F. R. Biol ogical aspects of Scenedesmus (Chlorophyceae) - phenotypic plasticity. Berlin: J. Cramer, 1998.
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NA. Biol Concepts& Connectns& Get Ready for Biol. Addison Wesley Publishing Company, 2006.
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NA. Biology& Biol Study GD Unbnd& Get Rdy Biol. Addison Wesley Publishing Company, 2007.
Find full textBook chapters on the topic "(Biol.)"
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Villarreal, Alisson Patricia Bolaños, Diana Elizabeth García Tumipamba, and Freddy Vicente Cuarán Sarzosa. "Vermicomposting: Production of Humus and Biol." In Communication, Smart Technologies and Innovation for Society, 591–600. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4126-8_53.
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Subklewe, Marion, and Reuben Benjamin. "Management of Myelotoxicity (Aplasia) and Infectious Complications." In The EBMT/EHA CAR-T Cell Handbook, 151–55. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_29.
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AbstractHaematologic toxicity is the most common adverse event after CAR-T cell therapy, with a cumulative 1-year incidence of 58% (CTCAE grade ≥ 3) in the real-world setting (Wudhikarn et al., Blood Advances 2020). It is characterized by a biphasic temporal course and is often prolonged (Fried et al., Bone Marrow Transplant 2019, Rejeski et al., Blood et al. 2021a, b, Fig. 29.1). In a report of Axi-Cel-treated patients, only 30% demonstrated a neutrophil count >1 × 109/L and 50% showed a platelet count >50 × 109/L at 30 days following CAR-T cell treatment (Jain et al., Blood Advances 2020). In a long-term follow-up study of patients with ongoing CR and an absence of MDS, 16% of patients experienced prolonged significant cytopenias that lasted up to 22 months after CAR-T cell treatment (Cordeiro et al., Biol Blood Marrow Transplant 2020). These findings highlight that cytopenia can present long after lymphodepletion and the resolution of acute CRS. Risk factors include severe CRS/ICANS, cytopenia prior to initiation of lymphodepleting chemotherapy, and prior allogeneic stem cell transplantation (Jain et al., Blood Advances 2020, Fried et al., BMT, 2019). Importantly, cytopenia predisposes patients to severe infectious complications, which are the most frequent cause of non-relapse mortality (Nastoupil et al., JCO 2020).
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Schilbach, Leonhard, and Juha M. Lahnakoski. "Clinical Neuroscience Meets Second-Person Neuropsychiatry." In Social and Affective Neuroscience of Everyday Human Interaction, 177–91. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08651-9_11.
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AbstractDisturbances of social and affective processes are at the core of psychiatric disorders. Together with genetic predisposing factors, deprivation of social contact and dysfunctional relationships during development are some of the most important contributors to psychiatric disorders over the lifetime, while some developmental disorders manifest as aberrant social behavior early in life. That the cause of mental illness is rooted in the brain was long held as a truism, yet finding the causes for and neurobiological correlates of these conditions in the brain has proven and continues to be difficult (Venkatasubramanian G, Keshavan MS, Ann Neurosci 23:3–5. https://doi.org/10.1159/000443549, 2016). In clinical practice, psychiatric disorders are diagnosed based on categorical manuals, such as the DSM and ICD, which form a useful guide for clinical diagnosis and interventions. Yet, understanding the specific neural mechanisms leading to or characterizing distinct psychiatric conditions through this categorical approach has been slow (see, for example, Lynch CJ, Gunning FM, Liston C, Biol Psychiatry 88:83–94. https://doi.org/10.1016/j.biopsych.2020.01.012, 2020). Findings in the brain often do not seem to lend support to common mechanisms for the defined disorder categories. This is not particularly surprising because, in these diagnostic manuals, multiple combinations of symptoms can often lead to the same diagnosis, which is reflected in highly variable phenotypes of psychiatric disorders.
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"11 (biol) Biologie Biology." In 2019, 664. De Gruyter, 2019. http://dx.doi.org/10.1515/9783110616576-035.
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"11. (biol) Biologie/ Biology." In 2018, 645. De Gruyter, 2018. http://dx.doi.org/10.1515/9783110608144-038.
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"11 (biol) Biologie Biology." In IJBF (2016). Berlin, Boston: De Gruyter, 2016. http://dx.doi.org/10.1515/9783110419863-035.
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"11 (biol) Biologie / Biology." In 2021, 682. De Gruyter, 2021. http://dx.doi.org/10.1515/9783110723922-038.
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"11 (biol) Biologie / Biology." In 2022, 688. De Gruyter, 2022. http://dx.doi.org/10.1515/9783110769593-036.
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"Comparative Genomics of Brucella melitensis, B. suis, and B. abortus." In Brucella:Molecular & Cell Biol, 99–116. Taylor & Francis, 2005. http://dx.doi.org/10.1201/9780203017456-11.
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"Erythritol Metabolism and Virulence in Brucella." In Brucella:Molecular & Cell Biol, 245–56. Taylor & Francis, 2005. http://dx.doi.org/10.1201/9780203017456-17.
Full textConference papers on the topic "(Biol.)"
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Lin, Fang-Tsyr, Victor T. G. Lin, Vivian Y. Lin, Yun-Ju Lai, Chen-Shan Chen, Kang Liu, and Weei-Chin Lin. "Abstract POSTER-BIOL-1333: TRIP6 regulates p27KIP1to promote ovarian tumorigenesis." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1333.
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Meza-Perez, Selene, Maria de la Luz Garcia-Hernandez, Aaron Silva-Sanchez, Javier Rangel-Moreno, Uma Mudunuru, Edith M. Lord, and Troy D. Randall. "Abstract POSTER-BIOL-1337: Omentum promotes suppression against peritoneal tumors." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1337.
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Chhina, J., S. Dar, M. Deshpande, S. Giri, A. Munkarah, and R. Rattan. "Abstract POSTER-BIOL-1307: Bioenergetic adaptations in chemoresistant ovarian cancer cells." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1307.
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Matthews, Dylan P., Sherine Taylor, and Neveen A. Said. "Abstract POSTER-BIOL-1344: Epigenetic regulation of SPARC in ovarian cancer." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1344.
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Brown, Caitlin W., Alexander S. Brodsky, and Richard N. Freiman. "Abstract POSTER-BIOL-1352: Notch3 promotes anoikis resistance in ovarian cancer." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1352.
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Hansen, Karyn J., and Bennett Van Houten. "Abstract POSTER-BIOL-1314: Investigating fatty acid beta-oxidation in ovarian cancer cells." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1314.
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Hudson, LG, SR Kenney, Y. Guo, S. Adams, T. Rutledge, CY Muller, and A. Wandinger-Ness. "Abstract POSTER-BIOL-1320: Rho-family GTPases as therapeutic targets in ovarian cancer." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1320.
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Walsh, Christine, Hoorig Nassanian, Hasmik Agadjanian, Carl Miller, Sandra Orsulic, and Beth Karlan. "Abstract POSTER-BIOL-1348: No association between PARK2 and BRCA1-associated gynecologic cancers." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1348.
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Reeve, E. B. "MODEL STUDIES OF NEUTRALIZATION OF THROMBIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643277.
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A kinetic model, based on published studies of thrombin neutralization, is used to examine factors that limit spread of free thrombin in a simple plasma. It employs equations with presently available rate parameters which describe the courses of the major thrombin-binding reactions at 37°C in buffered saline solutions approximating plasma ultrafiltrate. Thrombin is bound reversibly by fibrinogen and fibrin-1 polymers as enzyme-substrate complexes (1) and by “fibrin” at a non-proteolyt ic site (2), and essentially irreversibly by antithrombins (3). These bindings reduce free thrombin levels and so limit spread of activity. The model equations with parameters from (1) and (3) show that thrombin neutralization by thrombin-substrate complexes is very brief and thrombin-antithrombin reactions are much too slow for early reduction of thrombin activity. However, parameters from (2) show that rapid reversible binding of thrombin by “fibrin” much reduces level of free thrombin and the level continues to fall as the thrombin is passed to the antithrombins. The model shows that a rapidly-acting antithrombin (e.g. heparin-ATIII) could reduce free thrombin fast enough to inhibit slower thrombin activations (e.g. of FXIII), and that a sufficient concentration of a reversible binder can govern the level of free thrombin. This suggests that a non-toxic reversible binder, with suitable Kd and half-life, would be valuable in treating thrombosis. Verification and extension of the model findings require better experimental definition of the parameters.(1) Lewis, S.D. et al. J. Biol. Chem. 260, 10192-10199, 1985.(2) Liu, C.Y. et al. J. Biol. Chem. 254, 10421-10425, 1979.(3) Jordan, R. et al. J. Biol. Chem. 254, 2902-2913, 1979. (Supported by grants from the Colorado Heart Foundation)
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Pejovic, Tanja, Yukie Bean, Jaeyeon Kim, Martin M. Matzuk, and Seth B. Coffelt. "Abstract POSTER-BIOL-1308: Macrophage infiltration in high-grade serous carcinomas of humans and mice." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1308.
Full textReports on the topic "(Biol.)"
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Nelson, Nathan, and Charles F. Yocum. Structure, Function and Utilization of Plant Photosynthetic Reaction Centers. United States Department of Agriculture, September 2012. http://dx.doi.org/10.32747/2012.7699846.bard.
Full textAbstract:
Light capturing and energy conversion by PSI is one of the most fundamental processes in nature. In the heart of these adaptations stand PSI, PSII and their light harvesting antenna complexes. The main goal of this grant proposal was to obtain by X-ray crystallography information on the structure of plant photosystem I (PSI) and photosystem II (PSII) supercomplexes. We achieved several milestones along this line but as yet, like several strong laboratories around the world, we have no crystal structure of plant PSII. We have redesigned the purification and crystallization procedures and recently solved the crystal structure of the PSI supercomplex at 3.3 Å resolution. Even though this advance in resolution appears to be relatively small, we obtained a significantly improved model of the supercomplex. The work was published in J. Biol. Chem. (Amunts et al., 2010). The improved electron density map yielded identification and tracing of the PsaK subunit. The location of an additional 10 ß-carotenes, as well as 5 chlorophylls and several loop regions that were previously uninterruptable have been modeled. This represents the most complete plant PSI structure obtained thus far, revealing the locations of and interactions among 17 protein subunits and 193 non-covalently bound photochemical cofactors. We have continued extensive experimental efforts to improve the structure of plant PSI and to obtain PSII preparation amenable to crystallization. Most of our efforts were devoted to obtain well-defined subcomplexes of plant PSII preparations that are amenable to crystallization. We studied the apparent paradox of the high sensitivity of oxygen evolution of isolated thylakoids while BBY particles exhibit remarkable resilience to the same treatment. The integrity of the photosystem II (PSII) extrinsic protein complement as well as calcium effects arise from the Ca2+ atom associated with the site of photosynthetic water oxidation were investigated. This work provides deeper insights into the interaction of PsbO with PSII. Sight-directed mutagenesis indicated the location of critical sites involved in the stability of the water oxidation reaction. When combined with previous results, the data lead to a more detailed model for PsbO binding in eukaryotic PSII.