Relevant bibliographies by topics / Biologic growth and Biologic production

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Biologic growth and Biologic production'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Biologic growth and Biologic production"

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Dinarello, CA. "Biologic basis for interleukin-1 in disease." Blood 87, no. 6 (March 15, 1996): 2095–147. http://dx.doi.org/10.1182/blood.v87.6.2095.bloodjournal8762095.

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To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family, and the complexity of intracellular signaling. Mice deficient in IL-1Beta, IL-1Beta converting enzyme, and IL-1R type I have also been studied. Humans have been injected with IL- 1 (either IL-1alpha or IL-1beta) for enhancing bone marrow recovery and for cancer treatment. The IL-1-specific receptor antagonist (IL-1Ra) has also been tested in clinical trials. The topics discussed in this review include production and activities of IL-1 and IL-1Ra molecules, the effects of IL-1 on gene expression, functions of cell-bound and soluble IL-1 receptors, the importance of the IL-1R accessory protein, newly discovered signal transduction pathways, naturally occurring cytokines limiting IL-1 production or activity, the effects of blocking cyclooxygenase and nitric oxide, and the outcomes of IL-1 and IL-1 Ra in human trials. Special attention is paid to IL-1beta converting enzyme and programmed cell death. The roles of IL-1 in hematopoiesis, leukemia, atherosclerosis, and growth of solid tumors are also discussed. This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references. At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease.
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Nelson, Amy R., Barbara Fingleton, Mace L. Rothenberg, and Lynn M. Matrisian. "Matrix Metalloproteinases: Biologic Activity and Clinical Implications." Journal of Clinical Oncology 18, no. 5 (March 1, 2000): 1135. http://dx.doi.org/10.1200/jco.2000.18.5.1135.

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ABSTRACT: Tumor progression is a complex, multistage process by which a normal cell undergoes genetic changes that result in phenotypic alterations and the acquisition of the ability to spread and colonize distant sites in the body. Although many factors regulate malignant tumor growth and spread, interactions between a tumor and its surrounding microenvironment result in the production of important protein products that are crucial to each step of tumor progression. The matrix metalloproteinases (MMPs) are a family of degradative enzymes with clear links to malignancy. These enzymes are associated with tumor cell invasion of the basement membrane and stroma, blood vessel penetration, and metastasis. They have more recently been implicated in primary and metastatic tumor growth and angiogenesis, and they may even have a role in tumor promotion. This review outlines our current understanding of the MMP family, including the association of particular MMPs with malignant phenotypes and the role of MMPs in specific steps of the metastatic cascade. As scientific understanding of the MMPs has advanced, therapeutic strategies that capitalize on blocking the enzymes have rapidly developed. The preclinical and clinical evolution of the synthetic MMP inhibitors (MMPIs) is also examined, with the discussion encompassing important methodologic issues associated with determining clinical efficacy of MMPIs and other novel therapeutic agents.
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Kittler, EL, H. McGrath, D. Temeles, RB Crittenden, VK Kister, and PJ Quesenberry. "Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma." Blood 79, no. 12 (June 15, 1992): 3168–78. http://dx.doi.org/10.1182/blood.v79.12.3168.3168.

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Abstract The “stromal” or adherent cells of long-term murine Dexter explant bone marrow cultures provide the best in vitro model of the bone marrow microenvironment. Colony-stimulating factor-1 (CSF-1) is produced constitutively by these cells and is easily detected, but most investigators have not found constitutive production of the other hemolymphopoietic cytokines. We have previously reported the detection of granulocyte-macrophage-CSF (GM-CSF) in murine stromal cultures and its induction by the lectin Pokeweed mitogen. The present studies analyzing stromal cytokine messenger RNA (mRNA) production by standard Northern blot analysis show constitutive production of mRNAs for CSF-1, GM-CSF, granulocyte-CSF (G-CSF), c-kit ligand (KL), and interleukin-6 (IL-6), but not IL-3, IL-4, or IL-5 by 3-week irradiated or nonirradiated murine Dexter stromal cells. Exposure of stromal cells to Pokeweed mitogen or IL-1 16 hours before RNA harvest induces the messages for GM-CSF, G-CSF, KL, and IL-6, but not IL-3, IL-4, IL-5, or CSF-1. Polymerase chain reaction amplification of cDNA made with reverse transcriptase from stromal RNA using two separate sets of IL-3- specific primers shows the presence of IL-3 message in irradiated stromal cells, which is only detectable with this more sensitive technique. The factor-dependent cell lines FDC-P1 and 32D are supported by the stromal cells without the addition of exogenous growth factors, demonstrating a cytokine activity in these cultures that is inhibited by the addition of anti-IL-3 or anti-GM-CSF antibodies. These data indicate that murine Dexter stromal cells constitutively produce CSF-1, GM-CSF, G-CSF, IL-6, KL, and IL-3. This growth factor production could explain the support of granulocyte, macrophage, and megakaryocyte production and stem cell maintenance in Dexter-type long-term murine bone marrow cultures.
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Kittler, EL, H. McGrath, D. Temeles, RB Crittenden, VK Kister, and PJ Quesenberry. "Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma." Blood 79, no. 12 (June 15, 1992): 3168–78. http://dx.doi.org/10.1182/blood.v79.12.3168.bloodjournal79123168.

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The “stromal” or adherent cells of long-term murine Dexter explant bone marrow cultures provide the best in vitro model of the bone marrow microenvironment. Colony-stimulating factor-1 (CSF-1) is produced constitutively by these cells and is easily detected, but most investigators have not found constitutive production of the other hemolymphopoietic cytokines. We have previously reported the detection of granulocyte-macrophage-CSF (GM-CSF) in murine stromal cultures and its induction by the lectin Pokeweed mitogen. The present studies analyzing stromal cytokine messenger RNA (mRNA) production by standard Northern blot analysis show constitutive production of mRNAs for CSF-1, GM-CSF, granulocyte-CSF (G-CSF), c-kit ligand (KL), and interleukin-6 (IL-6), but not IL-3, IL-4, or IL-5 by 3-week irradiated or nonirradiated murine Dexter stromal cells. Exposure of stromal cells to Pokeweed mitogen or IL-1 16 hours before RNA harvest induces the messages for GM-CSF, G-CSF, KL, and IL-6, but not IL-3, IL-4, IL-5, or CSF-1. Polymerase chain reaction amplification of cDNA made with reverse transcriptase from stromal RNA using two separate sets of IL-3- specific primers shows the presence of IL-3 message in irradiated stromal cells, which is only detectable with this more sensitive technique. The factor-dependent cell lines FDC-P1 and 32D are supported by the stromal cells without the addition of exogenous growth factors, demonstrating a cytokine activity in these cultures that is inhibited by the addition of anti-IL-3 or anti-GM-CSF antibodies. These data indicate that murine Dexter stromal cells constitutively produce CSF-1, GM-CSF, G-CSF, IL-6, KL, and IL-3. This growth factor production could explain the support of granulocyte, macrophage, and megakaryocyte production and stem cell maintenance in Dexter-type long-term murine bone marrow cultures.
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Daynes, R. A., T. Dowell, and B. A. Araneo. "Platelet-derived growth factor is a potent biologic response modifier of T cells." Journal of Experimental Medicine 174, no. 6 (December 1, 1991): 1323–33. http://dx.doi.org/10.1084/jem.174.6.1323.

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Freshly isolated lymph node (LN) cells cultured in serum-containing medium were restricted to produce primarily interleukin 2 (IL-2) subsequent to T cell activation. Only minimal amounts of IL-4, IL-5, or interferon gamma (IFN-gamma) were produced under these conditions. Similar populations of LN cells cultured in serum-free medium were able to produce a variety of lymphokines after T cell activation, with the relative quantities of each species being dependent upon the lymphoid organ source of the lymphocytes. A similar relationship in the patterns of lymphokines produced by activated T cell hybridomas maintained under serum-free conditions was also observed, whereas activation in serum-supplemented media resulted in a predominant restriction to the secretion of IL-2. Additional studies determined that the entity in serum responsible for restricting T cell function in vitro was platelet-derived growth factor (PDGF). The PDGF-BB isoform was established to be the most active in the regulation of T cell function, enhancing IL-2 while depressing the production of IL-4, IL-5, and IFN-gamma at concentrations below 1 ng/ml. PDGF-AB was also found to be quite active, however, this isoform of PDGF was incapable of influencing IFN-gamma production at the concentrations tested. PDGF-AA was very weakly active. It therefore appears that PDGF, acting primarily through a beta receptor subunit (either alpha/beta- or beta/beta-type receptors) is able to influence profoundly the behavior of T cells, with some of its modulatory effects exhibiting isoform specificity. This is reflected by an enhancement in the production of IL-2, while simultaneously depressing the secretion of IL-4, IL-5, and IFN-gamma (PDGF-BB only) after T cell activation. Kinetic studies, where cell supernatants were analyzed both 24 and 48 h after T cell activation, suggested that "desensitization" to PDGF influences can occur naturally in vitro. Those species of lymphokines that were inhibited by PDGF over the first 24 h after activation could be produced at normal levels over the subsequent 24-h period. Finally, lymphokines maintained in the presence of PDGF-BB for greater than 24 h before their activation lost sensitivity to this growth factor. These cells regained responsiveness to PDGF after an additional incubation period in PDGF-free medium. Collectively, our data imply that the pattern of T cell lymphokines produced, plus the kinetics of their production after activation, are being controlled by the potent serum growth factor PDGF.(ABSTRACT TRUNCATED AT 400 WORDS)
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Mallis, Panagiotis, Catherine Stavropoulos-Giokas, and Efstathios Michalopoulos. "Introduction to the Special Issue on Stem Cell and Biologic Scaffold Engineering." Bioengineering 6, no. 3 (August 21, 2019): 72. http://dx.doi.org/10.3390/bioengineering6030072.

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Tissue engineering and regenerative medicine is a rapidly evolving research field that effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. In addition, tissue engineering requires the interaction of biologic scaffolds with cellular populations. Stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds, thus bringing artificial tissues one step closer to personalized medicine. In this special issue of Bioengineering, we highlight the beneficial effects of stem cells and scaffolds in the emerging field of tissue engineering. The current issue includes articles regarding the use of stem cells in tissue engineering approaches and the proper production of biologically based scaffolds like nerve conduit, esophageal scaffold, and fibrin gel.
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Newcom, SR, LH Muth, and ET Parker. "Production of monoclonal antibodies that detect Hodgkin's high molecular weight transforming growth factor-beta." Blood 75, no. 12 (June 15, 1990): 2434–37. http://dx.doi.org/10.1182/blood.v75.12.2434.2434.

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Abstract High molecular weight transforming growth factor-beta (TGF beta) is a physiologically active TGF secreted by nodular sclerosing Reed- Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGF beta from platelet-derived TGF beta using an enzyme-linked immunosorbent assay, neutralization of biologic activity, and Western blotting. These monoclonal antibodies directed at unique antigenic determinants (epitopes) of Hodgkin's TGF beta will allow further characterization of the role of Hodgkin's TGF beta in Hodgkin's disease and related entities.
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Newcom, SR, LH Muth, and ET Parker. "Production of monoclonal antibodies that detect Hodgkin's high molecular weight transforming growth factor-beta." Blood 75, no. 12 (June 15, 1990): 2434–37. http://dx.doi.org/10.1182/blood.v75.12.2434.bloodjournal75122434.

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High molecular weight transforming growth factor-beta (TGF beta) is a physiologically active TGF secreted by nodular sclerosing Reed- Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGF beta from platelet-derived TGF beta using an enzyme-linked immunosorbent assay, neutralization of biologic activity, and Western blotting. These monoclonal antibodies directed at unique antigenic determinants (epitopes) of Hodgkin's TGF beta will allow further characterization of the role of Hodgkin's TGF beta in Hodgkin's disease and related entities.
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Tosato, G., and KD Jones. "Interleukin-1 induces interleukin-6 production in peripheral blood monocytes." Blood 75, no. 6 (March 15, 1990): 1305–10. http://dx.doi.org/10.1182/blood.v75.6.1305.1305.

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Abstract Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet- derived growth factor. Some of these signals induce IL-6 effectively only in one cell type, and this selectivity of induction may explain selectivity of biologic effects. In the present study, we show that IL- 1 beta, previously known to be a potent inducer of IL-6 in fibroblasts, endothelial cells, and keratinocytes, but not in monocytes, is also a potent inducer of IL-6 in peripheral blood monocytes. High level IL-6 activity that could be neutralized by specific antibodies to IL-6 was detected in supernatants of IL-1-stimulated monocytes. Maximal induction required IL-1 concentrations of 10 ng/mL. As judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, IL-6 species of relative molecular mass of 19 to 26 Kd could be specifically immunoprecipitated from supernatants of IL-1- induced monocytes. Size heterogeneity is a reported feature of IL-6 produced in a variety of cell types, and monocyte-derived IL-6 induced by either IL-1 or LPS displayed similar size heterogeneity. The highly purified recombinant IL-1 beta preparation used contained little, if any, LPS. In addition, monocyte production of IL-6, induced by IL-1 beta, was specifically neutralized by anti-IL-1 beta antibodies, demonstrating that IL-1, rather than a contaminant in the IL-1 preparation, was responsible for IL-6 induction. A number of biologic activities have been ascribed both to IL-1 and IL-6. The finding that IL-1 induced IL-6 in monocytes may help in defining the spectrum of biologic activities of each of these interactive cytokines.
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Tosato, G., and KD Jones. "Interleukin-1 induces interleukin-6 production in peripheral blood monocytes." Blood 75, no. 6 (March 15, 1990): 1305–10. http://dx.doi.org/10.1182/blood.v75.6.1305.bloodjournal7561305.

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Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet- derived growth factor. Some of these signals induce IL-6 effectively only in one cell type, and this selectivity of induction may explain selectivity of biologic effects. In the present study, we show that IL- 1 beta, previously known to be a potent inducer of IL-6 in fibroblasts, endothelial cells, and keratinocytes, but not in monocytes, is also a potent inducer of IL-6 in peripheral blood monocytes. High level IL-6 activity that could be neutralized by specific antibodies to IL-6 was detected in supernatants of IL-1-stimulated monocytes. Maximal induction required IL-1 concentrations of 10 ng/mL. As judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, IL-6 species of relative molecular mass of 19 to 26 Kd could be specifically immunoprecipitated from supernatants of IL-1- induced monocytes. Size heterogeneity is a reported feature of IL-6 produced in a variety of cell types, and monocyte-derived IL-6 induced by either IL-1 or LPS displayed similar size heterogeneity. The highly purified recombinant IL-1 beta preparation used contained little, if any, LPS. In addition, monocyte production of IL-6, induced by IL-1 beta, was specifically neutralized by anti-IL-1 beta antibodies, demonstrating that IL-1, rather than a contaminant in the IL-1 preparation, was responsible for IL-6 induction. A number of biologic activities have been ascribed both to IL-1 and IL-6. The finding that IL-1 induced IL-6 in monocytes may help in defining the spectrum of biologic activities of each of these interactive cytokines.
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Dissertations / Theses on the topic "Biologic growth and Biologic production"

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Strandberg, Per Erik. "Mathematical models of bacteria population growth in bioreactors: formulation, phase space pictures, optimisation and control." Thesis, Linköping University, Department of Mathematics, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2337.

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There are many types of bioreactors used for producing bacteria populations in commercial, medical and research applications.

This report presents a systematic discussion of some of the most important models corresponding to the well known reproduction kinetics such as the Michaelis-Menten kinetics, competitive substrate inhibition and competitive product inhibition. We propose a modification of a known model, analyze it in the same manner as known models and discuss the most popular types of bioreactors and ways of controlling them.

This work summarises much of the known results and may serve as an aid in attempts to design new models.

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Rorrer, Rebecca Kathleen. "Veterinary Therapeutic and Biologic Agents in Virginia Sheep Production." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34574.

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Biological and therapeutic agents are used in food animal production to maintain animal health and well being, prevent and treat disease, and to maintain or enhance production. Concerns about the use of pharmaceutical agents in food animal production have been raised, especially in relation to food quality and safety. This study addressed the scarcity of information concerning the quantity of pharmaceuticals being used and the reasons for their use in sheep production. Additional goals included determining the sources of information used by shepherds in making treatment decisions and evaluating the economic impact that pharmaceutical usage has on sheep production. Thirty-nine Virginia sheep producers participated in this study of four months duration from March through September. After completing an initial questionnaire to determine flock and management characteristics, participants were asked to record all treatments with biological and therapeutic agents that occurred within their sheep flocks. A total of 14,310 treatments were recorded for a median of 1.5 treatments per sheep per month. Parasite control and vaccination were the most frequent reasons for treatment (64.9% and 15.2%, respectively) with vitamin/mineral supplementation being the next most common (8.8%). Price information was collected for 13,912 treatment events. An estimated total of $7,523.78 was spent on pharmaceutical treatment over the course of the study. This amounts to a cost of $0.63 per sheep per month of observation. Results of this study will enhance the ability of producers to evaluate treatment decisions, allow comparisons to be made between operations and provide a base of information for future research.
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Wachtel, Heather. "Polymorphisms and Biologic Effects of Acidic Mammalian Chitinase in Asthma." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-03102009-162717/.

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In this study, we hypothesize that human acidic mammalian chitinase (AMCase) binds and is regulated by the epidermal growth factor receptor (EGFR), and that AMCase interacts with Galectin-3 (Gal-3) to mediate anti-apoptotic functions. We further hypothesize that asthma-associated polymorphisms of AMCase alter chitinase activity and modulate anti-apoptotic effects. We investigated the interactions between AMCase, Gal-3 and EGFR by establishing binding and co-expression in vitro; apoptotic effects were evaluated via Annexin V/Propidium Iodide staining. Molecular cloning was performed to generate single nucleotide polymorphisms (SNPs) of AMCase associated with asthma. Our data showed that co-expression of AMCase and EGFR induces chitinase activity; we found that AMCase and Gal-3 bind each other in vitro, and that they co-localize in the cytoplasm of cells. Co-transfection of AMCase and Gal-3 demonstrates greater anti-apoptotic effect than Gal-3 alone, while recombinant Gal-3 induces apoptosis, which is not blocked by incubation with recombinant AMCase. From these data, we conclude that AMCase is regulated by EGFR, and that AMCase and Gal-3 physically interact, however contrary to our hypothesis, the anti-apoptotic effects of AMCase are unlikely to be mediated by Gal-3. Further exploration of this pathway using SNP constructs generated in this study will shed light on the mechanism of AMCase in asthma.
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Robinson, Stephen D. "The Historical Production of Elemental Phosphorus in Pinellas County, Florida: An Environmental Assessment." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002075.

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Gustafsson, Pär. "Forest-stream linkages : Experimental studies of foraging and growth of brown trout (Salmo trutta L)." Licentiate thesis, Karlstad University, Faculty of Social and Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1649.

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Riparian vegetation along streams and rivers affects the aquatic community in numerous ways and often operates as a link for energy flux between forest and streams. The studies presented in this licentiate thesis focus on light and terrestrial invertebrates, two factors influenced by riparian zone structure, which potentially affect stream ecosystems and thus also brown trout (Salmo trutta). Paper I is a laboratory experiment where I study size dependent foraging behavior on surface-drifting terrestrial invertebrates and benthic invertebrates by brown trout. The results show a size-dependent difference in foraging ability with large trout being better able to use terrestrial surface prey than small trout. I argue that such ontogenetic foraging differences are due to both morphological constraints (eg. gape limitation) and size dependent behavioral differences related to predation risk. Paper II consists of a 5 month-long 2x2 factorial design field experiment where my objective was to examine the effects of terrestrial invertebrate input and solar radiation (PAR) on different trophic levels in a boreal headwater stream. More specifically, I followed the effects of increased light and decreased terrestrial invertebrate subsidies on periphyton, benthic macroinvertebrates and two size classes of the top fish predator, brown trout. The results showed that the reduction of terrestrial invertebrate input had size- and seasonal-dependent effects on trout, where large trout had lower growth rates than small trout, mainly in summer. Diet analyses of trout supported growth differences in that large trout in unmanipulated enclosures consumed relatively more terrestrial prey than large trout living in enclosures with reduced terrestrial inputs. A higher reliance on terrestrial prey subsidies by large trout compared to small may be explained by ontogenetic differences in foraging and habitat choice. Despite a 2.5-fold increase in PAR, light did not have an effect on chlorophyll a biomass, nor was there an effect on the density or composition of benthic macroinvertebrates. The lack of effects on primary production may be explained by very low nutrient levels in the stream.

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Takaba, Kiyoaki. "A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic ischemic myocardium : evolving concept of biologic coronary artery bypass grafting." Kyoto University, 2007. http://hdl.handle.net/2433/135664.

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Davies, Oluwafemi. "Recombinant protein production in the chloroplast of microalgae : a systems biology approach." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/recombinant-protein-production-in-the-chloroplast-of-microalgae-a-systems-biology-approach(fe23d3a0-a882-48e0-8171-53cc05225db2).html.

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Several expression systems for recombinant protein production, essentially cells or whole organisms are currently in use today. Recently, research into recombinant protein production revealed a more attractive expression system based on the microalgae, C. reinhardtii, for significant savings in cost and production of correctly folded recombinant proteins. However, protein yield in the microalgae remain very low, non-predictable and whether this was due to limitations in the system was unclear. Using the expression of E. coli β-glucuronidase (gus) in C. reinhardtii chloroplast, the overall aim of the project was to address if the low recombinant gus yield in C. reinhardtii was due to limitations that affect growth and protein production, and if the fluxes for recombinant gus production were suboptimal (limiting). The finding was used to implement a strategy for a more predictable recombinant protein yield in C. reinhardtii. The research involved a range of experiments, analysis, and Flux Balance Analysis (FBA) modelling. The growth of C. reinhardtii cultures were characterized in autotrophic, heterotrophic and mixotrophic conditions to identify factors that limit growth and recombinant gus yields. These factors were availability of light, carbon and nitrogen substrates, pH changes, protein burden and energetic limitation (ATP). The highest biomass was obtained in autotrophic and mixotrophic cultures (>1 g/litre), the lowest biomass was in heterotrophic cultures (~0.4 g/litre). The recombinant gus yields on the basis of dry cell weight were: mixotrophic cultures (0.038%), autotrophic cultures (0.032%), heterotrophic cultures (0.026%). No detectable protein burden was observed for expression of recombinant gus in autotrophic and mixotrophic conditions, but protein burden was significant in heterotrophic condition (15 – 18% reduction in growth rate). A strategy that significantly increased growth and cell productivity (>3 fold) in heterotrophic condition was identified. FBA was used to identify suboptimal amino acid steady state fluxes (bottlenecks) that limited the gus yield. Using FBA modelling, model verifications and corrections, a strategy that significantly increased the yield of recombinant gus in each cell (~2 fold) was identified. Put together, the total increase represents a 6 fold increase in recombinant gus yield. Furthermore, this research presented a framework for identifying, analysing and understanding the effect of the uptake of individual amino acid towards recombinant protein yield.
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Boutros, Tarek. "Interferon-beta is a potent promoter of nerve growth factor production by astrocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0005/MQ37098.pdf.

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Pinna, Adriano. "Modelling growth dynamics and toxin production in Ostreopsis cf. ovata." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6763/.

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The benthic dinoflagellate O. ovata represents a serious threat for human health and for the ecology of its blooming areas: thanks to its toxicity this microalga has been responsible for several cases of human intoxication and mass mortalities of benthic invertebrates. Although the large number of studies on this dinoflagellate, the mechanisms underpinning O. ovata growth and toxin production are still far to be fully understood. In this work we have enriched the dataset on this species by carrying out a new experiment on an Adriatic O. cf. ovata strain. Data from this experiment (named Beta) and from another comparable experiment previously conducted on the same strain (named Alpha), revealed some interesting aspects of this dinoflagellate: it is able to grow also in a condition of strong intracellular nutrient deficiency (C:P molar ratio > 400; C:N > 25), reaching extremely low values of chlorophyll-a to carbon ratio (0.0004). Was also found a significant inverse relationships (r > -0.7) between cellular toxin to carbon and cellular nutrient to carbon ratios of experiment Alpha. In the light of these result, we hypothesized that in O. cf. ovata nutrient-stress conditions (intended as intracellular nutrient deficiency) can cause: i) an increase in toxin production; ii) a strong decrease in chlorophyll-a synthesis; iii) a lowering of metabolism associated with the formation of a sort of resting stage. We then used a modelling approach to test and critically evaluate these hypotheses in a mechanistic way: newly developed formulation describing toxin production and fate, and ad hoc changes in the already existent formulations describing chlorophyll synthesis, rest respiration, and mortality, have been incorporated in a simplified version of the European Regional Seas Ecosystem Model (ERSEM), together with a new ad hoc parameterization. The adapted model was able to accurately reproduce many of the trends observed in the Alpha experiment, allowing us to support our hypotheses. Instead the simulations of the experiment Beta were not fully satisfying in quantitative terms. We explained this gap with the presumed different physiological behaviors between the algae of the two experiments, due to the different pre-experimental periods of acclimation: the model was not able to reproduce acclimation processes in its simulations of the experiment Beta. Thus we attempt to simulate the acclimation of the algae to nutrient-stress conditions by manual intervention on some parameters of nutrient-stress thresholds, but we received conflicting results. Further studies are required to shed light on this interesting aspect. In this work we also improve the range of applicability of a state of the art marine biogeochemical model (ERSEM) by implementing in it an ecological relevant process such as the production of toxic compounds.
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Çebi, Zehra [Verfasser], Michael [Gutachter] Melkonian, and Burkhard [Gutachter] Becker. "Efficient microscale screening of various Haematococcus pluvialis strains for growth and astaxanthin production / Zehra Çebi ; Gutachter: Michael Melkonian, Burkhard Becker." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1138027219/34.

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Books on the topic "Biologic growth and Biologic production"

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Inke, Gábor. The protolobar structure of the human kidney: Its biologic and clinical significance. New York, NY: Liss, 1988.

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2

Oetting, Ronald D. The biologic and economic assessment of chlorpyrifos and diazinon in ornamentals and sod production. [Washington, D.C.?]: The Program, 1994.

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Primary production in arable crops: Above-ground growth dynamics, net production and nitrogen uptake. Uppsala: Swedish University of Agricultural Sciences, Dept. of Ecology and Environmental Research, 1987.

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Backéus, Ingvar. Aboveground production and growth dynamics of vascular bog plants in central Sweden. Uppsala: Svenska växtgeografiska sällskapet, 1985.

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Uskov, Aleksandr, Evgeniy Mozhaev, Lyudmila Uskova, and Elena Zakabunina. Potato growing. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1030568.

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The textbook covers the main topics related to the national economic significance, origin, distribution of potatoes; morphological and anatomical structure of potato plants. Features of potato biology by periods of growth and development, as well as its requirements for growing conditions are given. Technological methods of cultivation, the system of fertilization and protection from pests, diseases and weeds, seed production and varietal studies, the economy of potato production are presented. Meets the requirements of the Federal state educational standards of higher education of the latest generation for the preparation of bachelors. For undergraduate students studying in the field of "agronomy", as well as specialists in agricultural production.
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Fontanesi, Luca, ed. The genetics and genomics of the rabbit. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781780643342.0000.

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Abstract The purpose of the book is to present in one location a comprehensive overview of the progress of genetics in the rabbit, with a modern vision that integrates genomics to obtain a complete picture of the state of the art and of the applications in this species, defined according to the multiple uses and multi-faceted places that this species has in applied and fundamental biology. The 18 chapters cover several fields of genetics and genomics: Chapters 1 and 2 present the rabbit within the evolutionary framework, including the systematics, its domestication and an overview of the genetic resources (breeds and lines) that have been developed after domestication. Chapters 3-5 cover the rabbit genome, cytogenetics and genetic maps and immunogenetics in this species. Chapters 6-8 present the genetics and molecular genetics of coat colours, fibre traits and other morphological traits and defects. Chapters 9-13 cover the genetics of complex traits (disease resistance, growth and meat production traits, reproduction traits), reproduction technologies and genetic improvement in the meat rabbits. Chapters 14-18 present the omics vision, the biotech and biomodelling perspectives and applications of the rabbit. This book is addressed to a broad audience, including students, teachers, researchers, veterinarians and rabbit breeders.
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Dworkin, Ian, Daniel A. Fung, and Timothy T. Davis. Biologic and Regenerative Therapies. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0027.

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Low back pain is one of the most debilitating conditions worldwide, and a major cause is degenerative disc disease. Current therapies range from conservative treatments, such as medications, physical therapy, and other modalities, to more invasive treatments such as injections and surgery; however, these therapies neither stop the progression of degeneration nor restore function to the degenerating disc; they focus on symptom management, not on etiology. A novel approach to treating degenerative disc disease involves using regenerative therapies such as stem cells, growth factors, and gene therapy. The goal of these therapies is not just to decrease symptoms, but to reverse disc degeneration, while simultaneously enhancing current treatment modalities. Though clinical translation of regenerative therapies is in its infancy, in vitro and in vivo investigations have revealed these therapies’ potential in treating degenerative disc disease as well as a multitude of other musculoskeletal conditions.
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Carpenter, Graham. The EGF Receptor Family: Biologic Mechanisms and Role in Cancer. Academic Press, 2003.

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Carpenter, Graham. The EGF Receptor Family: Biologic Mechanisms and Role in Cancer. Academic Press, 2003.

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M, Wheeler R., and John F. Kennedy Space Center., eds. System development and early biological tests in NASA's biomass production chamber. [Kennedy Space Center, Fla.]: National Aeronautics and Space Administration, John F. Kennedy Space Center, 1990.

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Book chapters on the topic "Biologic growth and Biologic production"

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Miller, Sharon A., Janusz Z. Beer, Nelson T. Lao, and Barbara Z. Zmudzka. "Production and Persistence of UV-Induced Tan." In Biologic Effects of Light 2001, 113–26. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0937-0_10.

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Holick, E. A., Z. Lu, M. T. Holick, T. C. Chen, J. Sheperd, and M. F. Holick. "Production of Previtamin D3 by a Mercury Arc Lamp and a Hybrid Incandescent/Mercury Arc Lamp." In Biologic Effects of Light 2001, 205–12. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0937-0_20.

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Ferguson, Gary W., William H. Gehrmann, Stephen H. Hammack, Tai C. Chen, and Michael F. Holick. "Effects of Dietary Vitamin D and UVB Irradiance on Voluntary Exposure to Ultraviolet Light, Growth and Survival of the Panther Chameleon." In Biologic Effects of Light 2001, 193–203. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0937-0_19.

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Allain, Daniel. "Genetics of fibre and fur production in rabbits." In The genetics and genomics of the rabbit, 104–19. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781780643342.0007.

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Abstract This chapter aims to present the genetics of fibre and fur production in the rabbit. It focuses first on general biology of hair covering and hair development of the rabbit. A clear understanding of the biological basis of the coat is essential for a better understanding of the genetic basis of fibre and fur production. It then examines the genetic basis of hair growth pattern and coat composition for fibre and fur production. Selection of rabbit on coat colour, a component of fur production, will be dealt with very briefly. Genetics and molecular genetics of coat colour is the subject of Chapter 6 of this book.
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Rogol, A. D. "Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human." In Biologic Rhythms in Clinical and Laboratory Medicine, 167–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-78734-8_12.

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Mol, Jan A., Irma Lantinga van Leeuwen, Evert van Garderen, and Ad Rijnberk. "Progestin-induced Mammary Growth Hormone (GH) Production." In Biology of the Mammary Gland, 71–76. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46832-8_8.

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Andersen, J. A., J. M. Nielsen, G. L. Ottesen, and J. L. Thomsen. "In Situ Carcinoma of the Female Breast: Frequency, Growth Pattern and Biologic Significance." In Breast Diseases, 513–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73523-3_51.

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Reyes, Luis H., and Katy C. Kao. "Growth-Coupled Carotenoids Production Using Adaptive Laboratory Evolution." In Methods in Molecular Biology, 319–30. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7295-1_20.

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Dinarello, C. A. "Interleukin 1 Production from Various Cells and Measurement of its Multiple Biologic Activities." In Handbook of Experimental Pharmacology, 215–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73217-1_8.

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Schiele, Nathan R., David T. Corr, and Douglas B. Chrisey. "Laser Direct Writing of Idealized Cellular and Biologic Constructs for Tissue Engineering and Regenerative Medicine." In Laser-Surface Interactions for New Materials Production, 261–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03307-0_11.

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Conference papers on the topic "Biologic growth and Biologic production"

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Tsivka, K., Aleksandr Popov, M. Hafez, M. Rashad, and Natalya Kovaleva. "MAIN WAYS TO OPTIMIZE THE CULTIVATED PLANT PRODUCTIVITY ON LAND LIABLE TO DEGRADATION." In Land Degradation and Desertification: Problems of Sustainable Land Management and Adaptation. LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1684.978-5-317-06490-7/96-100.

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The purpose of this publication was to describe the main ways to optimize the productive process of cultivated plants on land subject to degradation. There are three kinds of correction: physical, chemical and biological. Biological correction is new way to optimize the production process of crops, which is a set of methods of directive effect on plant biology. The key points and essence of biological correction are considered. One of the most effective and economically justified methods of biological correction of plant productivity is non-root treatment of crops by humic substances (HSs) solutions, especially those containing essential macro-and microelements. Such treatments can reduce the negative effects of projected global climate change (excessive UV-B radiation, drought, etc.) on agricultural plants. As confirmation, the results of a field experiment conducted in the arid territory of Egypt are presented. Means of biological correction, such as: Azospirillum sp., vermicompost and HSs solutions (without and with trace elements) were very effective, they increased (more than 2.5 times!) the yield of wheat grain. Thus, to obtain a consistently high crop yield on land subject to degradation, especially in changing climatic conditions, it is necessary to apply three kinds of correction: physical, chemical and biological. Both physical correction and chemical one create the necessary conditions for the growth and development of plants, and biological correction "forces" plants to show their reserve functions, contributing to an additional increase in crop yield.
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Агеева, Полина, Polina Ageeva, Марина Матюхина, Marina Matyukhina, Наталья Почутина, and Natalya Pochutina. "EVALUATION OF NARROW-LEAFED LUPIN VARIETIES FOR SOME MORPHOLOGICAL AND BIOLOGICAL CHARACTERS." In Multifunctional adaptive feed production. ru: Federal Williams Research Center of Forage Production and Agroecology, 2019. http://dx.doi.org/10.33814/mak-2019-21-69-20-25.

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The article presents the tests results of narrow-leafed lupin for some morphological and biological characters: height and initial growth of plants, their productivity (seeds amount and weight), seed amount per a pod, microdistribution coefficient etc. Vars. Beloro-zovy 114, BL 78-07 and Hybrid 1215 stood out in plant height (68.6–81.3 sm); Uzkolistny 53-02, Belozerny 110 and Smena — in seeds amount per a pod (4.44–4.08 seeds). Low alkaloid content (0.038%) had the vars. Belorozovy 144 and Smena.
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Trofimov, I. A., L. S. Trofimova, E. P. Yakovleva, A. V. Emelyanov, E. V. Skripnikova, A. S. Gorbunov, O. P. Bykovskaya, et al. "Environmental management in crop production and agriculture in the Black earth zone of Russia." In Растениеводство и луговодство. Тимирязевская сельскохозяйственная академия, 2020. http://dx.doi.org/10.26897/978-5-9675-1762-4-2020-117.

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The main problems of environmental management in the crop production and agriculture in the Black earth zone of Russia are discussed. The solution to these problems focuses on perennial herbs, herbal ecosystems and agrolandscapes, biologic and greening agriculture.
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Wogan, David M., Alexandre K. da Silva, and Michael Webber. "Assessing the Potential for Algal Biofuels Production in Texas." In ASME 2009 3rd International Conference on Energy Sustainability collocated with the Heat Transfer and InterPACK09 Conferences. ASMEDC, 2009. http://dx.doi.org/10.1115/es2009-90235.

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This paper describes a unique analytical model created to assess the maximum potential for algae production in Texas. The model, which merges engineering, biology and geosciences into a singular analysis, aims to identify suitable growth locations and estimate the quantity of algae-based oils that can be potentially produced in Texas. The model incorporates geographically- and temporally-resolved data on sunlight, anthropogenic CO2 emissions, and saline or brackish water availability. These data are then overlaid with first-order biological approximations for algae growth calculations in order to create maps of algae growth potential. Solar insolation data were obtained from measurement locations throughout the state for varying time scales spanning many years from the Texas Solar Radiation Database (TSRDB). CO2 emissions were compiled from area and point sources (such as natural gas and coal-fired power plants) from the Energy Information Administration and Environmental Protection Agency. Water data for wastewater treatment plants and saline aquifers were obtained from the Texas Commission on Environmental Quality and the Texas Water Development Board. A home-built MATLAB code uses these data, along with engineering approximations and the ability to manipulate different assumptions to calculate algae growth by location and time period. For each location, the model calculates potential oil yield, biomass produced, growth rates, water and CO2 consumed and land used. Standard pond and tubular photobioreactor dimensions have been used to model real world production facilities. Realistic limits for growth rates, photosynthetic efficiencies, photosynthetic flux tolerances and oil content are also incorporated. These parameters can be varied to approximate different algae strains and growth conditions. The model assumes reactors to have ideal mixing, optimal pH and temperature controls in place. This preliminary resource assessment estimates that Texas receives an average of 375 W/m2 annually, produces 409 million tons per year of CO2 from the industrial and electrical power sectors and has approximately 1.4 trillion gallons per year of available water on a sustainable basis. The computational model estimates that between 44 and 167 million tons of algal biomass and 3.1 to 12 billion gallons of lipids can be produced annually in Texas based on the combination and availability of these resources.
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Nikolova, Marina. "ANALYSIS OF THE STATE AND TRENDS IN THE DEVELOPMENT OF ORGANIC PRODUCTION IN THE NORTH CENTRAL AREA." In AGRIBUSINESS AND RURAL AREAS - ECONOMY, INNOVATION AND GROWTH 2021. University publishing house "Science and Economics", University of Economics - Varna, 2021. http://dx.doi.org/10.36997/ara2021.255.

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Organic farming best meets the benchmarks set in the development of the Common Agricultural Policy after 2020, regarding the achievement of important goals related to economic efficiency, social responsibility and environmental protection. Therefore, the protection and restoration of biodiversity and natural ecosystems and the provision of sustainable food and production practices are key to our national economy. This requires the use of sustainable production models for effective management of the components of agricultural ecosystems, environmental protection and climate change. The focus of the study is on the regional specifics of an innovative agricultural model and its development potential for strengthening the socio-economic indicators in a specific region. The subject of the analysis is the characteristics of the organic production in the North Central Planning Region depending on the certified activities and the number of biological operators.
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Cecil, Denise L., Kyong Hwa Park, Ekram Gad, and Mary L. Disis. "Abstract 2401: IGF-IR peptide vaccine inhibits tumor growth via IFN-g-dependent biologic remodeling of the tumor." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2401.

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Volkova, E. S. "INFLUENCE OF FERTILIZERS AND BIOLOGICAL PREPARATIONS ON SOME INDICATORS OF GROWTH AND DEVELOPMENT OF FODDER WINTER RYE." In «Breeding, seed production, cultivation technology and processing of agricultural crops». Federal State Budgetary Scientific Institution Federal Scientific Rice Centre, 2021. http://dx.doi.org/10.33775/conf-2021-268-275.

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Shulaev, G. M., and R. K. Milushev. "IMPROVMENT THE BIOLOGICAL VALUE OF PORK." In INNOVATIVE TECHNOLOGIES IN SCIENCE AND EDUCATION. DSTU-Print, 2020. http://dx.doi.org/10.23947/itno.2020.467-471.

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The purpose - improve the quality of pig farming production through the use of functional feed additive at the final stage of feeding. The additive ingredients (in %): vitamin E - 0,32; vitamin D₃ - 0,30; vitamin C - 0,30; vitamin B₄ - 1,56; vitamin B₁₂ - 0,004; betaine - 10,00; %; bentonite - 77,166; Omek J – 0,15%; selen - 0,2 %; soya flour (filling substance) - 10,00. Components activity: vitamin E-50,0 of %; D₃ - 0,15,0 thousand ME in 1g; B₄ - 60,0 %; B₁₂ - 1,0%; Omek J - 2,0%; seleno-KI - 0,2 %. The functional feed additive is approved on fattened pigs of large white breed. Animals from control group received the mixed fodder constantly used in a factory, skilled - same as well as control, but the containing 1 % of the additive within 10 days before slaughter. Growth, some indicators of a metabolism, quality of meat are studied.
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PUSHKAREV, Ivan A., Nikolay V. SHANSHIN, Yuriy A. KHAPERSKY, Kristina V. KIREYEVA, and Antonina I. AFANASYEVA. "Biological Features and Growth Intensity of Calves after Introduction of Tissue Biostimulator to Dry Cows." In XVIII International Scientific and Practical Conference "Modern Trends in Agricultural Production in the World Economy". Sibac, 2020. http://dx.doi.org/10.32743/kuz.agri.2020.85-93.

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Woods, Pamela, Bradley A. Krisanits, Dion Foster, Lourdes M. Nogueira, Laura Spruill, Marvella E. Ford, Michael B. Lilly, Victoria J. Findlay, and David P. Turner. "Abstract B047: Advanced glycation end products promote prostate tumor growth and are a potential biologic consequence of lifestyle factors contributing to cancer disparity." In Abstracts: Eleventh AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; November 2-5, 2018; New Orleans, LA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp18-b047.

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Reports on the topic "Biologic growth and Biologic production"

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Saillant, Eric, Jason Lemus, and James Franks. Culture of Lobotes surinamensis (Tripletail). Mississippi Department of Marine Resources, January 2014. http://dx.doi.org/10.18785/ose.001.

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The Tripletail, Lobotes surinamensis, is a pelagic fish found in tropical and sub-tropical waters of all oceans. Tripletails are often associated with floating debris and make frequent incursions in bays and estuaries where they are targeted by recreational fishermen. In Mississippi waters the species is typically present during the late spring and summer season that also correspond to the period of sexual maturation and spawning (Brown-Peterson and Franks 2001). Tripletail is appreciated as a gamefish but is also prized for its flesh of superior quality. The fast growth rate of juveniles in captivity documented by Franks et al. (2001) and the excellent quality of Tripletail flesh both contribute to the potential of this species for marine aquaculture. In addition, the production of cultured juveniles would be precious to develop a better understanding of the biology, early life history and habitat use of Tripletail larvae and juveniles, a topic largely undocumented to date, through experimental releases and controlled studies. The culture of tripletail thus supports the Tidelands Trust Fund Program through improved conservation of natural resources, potential enhancement of fisheries productivity and potential development of a new economic activity on the Gulf coast producing tripletail via aquaculture. The Objective of this project was to initiate development of methods and techniques needed to spawn captive held tripletail broodfish and raise their offspring to evaluate their growth and development in captivity. In this report we will present the results of studies aiming to develop methods and protocols for captive spawning of tripletail and the first data obtained on the early development of tripletail larvae. A major issue that was encountered with tripletail broodstock development during the project lied in the difficulties associated with identifying the sex of adults caught in the wild and candidates for being incorporated in mating sets for spawning. This issue was addressed during the course of the project by examining the potential of a non-lethal method of hormonal sexing. The results of these preliminary investigations are presented in the third part of this report. All protocols used in the project were determined with the guidance of the Institutional Animal Care and Use Committee (IACUC) of the University of Southern Mississippi (USM IACUC protocol number 10100108).
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