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Dissertations / Theses on the topic 'Biological active compound'

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Published: 5 June 2025
Last updated: 1 August 2025

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1

Esmati, Nasim. "Synthesis of Biologically Active Compounds via Multicomponent Reactions and Evaluation of Their Biological Activities." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525897360405194.

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2

Omar, Muhammad Nor bin. "Synthesis of biologically active compounds." Thesis, Liverpool John Moores University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343121.

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3

Burnell, Erica Sinead. "Synthesis of biologically active compounds." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-biologically-active-compounds(a009591b-d439-4ff7-9e6f-36199a33e7c8).html.

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Part 1 describes the synthesis of (2S,3S,4R,5R)-5-(6-(((7-bromo-2-(dimethylamino)-4-((3-methylisoxazol-5-yl)methoxy)benzo[d]oxazol-5-yl)methyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide, a selective A3 adenosine receptor agonist, and one of a number of adenosine analogues designed by Muscagen Ltd. with the purpose of treating cardiac ischaemia. The target compound was derived from a condensation of the known modified adenosine, (3aS,4S,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-N,2,2-trimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide with 5-(aminomethyl)-7-bromo-N,
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4

Salunkhe, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3270.

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5

Dhokte, U. P. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3299.

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6

Naik, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3274.

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7

Khobragade, D. A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2529.

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8

Kumar, A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1989. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3326.

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9

Bhonsle, J. B. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1992. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3034.

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10

Vidyasagar, V. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3228.

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11

Reddy, P. S. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3232.

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12

Mohamadi, Shahrzad. "Electrochemical screening of biological membrane active compounds." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8619/.

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Interactions of biomembrane-active compounds with phospholipid monolayers on microfabricated Pt/Hg electrodes in an on-line high throughput flow system are demonstrated by recording capacitance current peak changes in rapid cyclic voltammograms (RCV). Detection limits of the compounds' effects on the layer have been estimated from the data. Compounds studied include steroids, polycyclic aromatic hydrocarbons, tricyclic antidepressants, tricyclic phenothiazines pyridinium compounds, spiperone and spiperone analogues and a range of serotonin and dopamine receptor ligands. The results show that t
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13

Nachman, J. "Structural studies on biologically active compounds." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356662.

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14

Birch, D. J. "The synthesis of biologically active compounds." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233498.

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15

Wilson, Jennifer M. "Synthesis of biologically active heterocyclic compounds." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/45/.

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More than 11 million people worldwide are diagnosed with cancer every year. New cancer drugs are required that are more effective and selective. Nitrogen mustard alkylating agents crosslink DNA inhibiting transcription and replication. Use of the mustard pharmacophore as part of a macrocycle allows metal complexation and produces a prodrug. Hypoxic tumour cells have increased concentrations of reductase enzymes which could lead to reduction of the complex in situ and release of a cytotoxic drug. Human African Trypanosomiasis is commonly known as Sleeping Sickness and affects over 36 countries
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16

Whapham, Catherine. "Biologically-active compounds in seaweed extracts." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310473.

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17

Upadhye, B. K. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2974.

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18

Menon, R. B. "Synthetic studies on biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2970.

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19

Gupta, M. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3254.

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20

Kamalam, M. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3221.

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21

Joshi, G. S. "Synthetic studies in biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3288.

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22

Kher, S. M. "Synthetic studies in biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3000.

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23

Garyali, K. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3240.

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24

Sivadasan, L. "Synthesis of some biologically active compounds." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2228.

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25

Bhosale, S. S. "Synthetic studies in biologically active organic compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3217.

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26

Randad, R. S. "Synthetic transformations leading to biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3223.

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27

Jadhav, C. B. "Study of biologically active compounds by hplc." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1991. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1995.

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28

Mutlu, Esra. "Synthetic and Analytical Studies of Biologically Active Compounds." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489838.

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first part of the project aimed to access tetralone intermediates required for the benzo[f]quinazoline inhibitors of thymidylate synthase. The project focussed sibility ofusing the intramolecular Buchner reaction to devise a short route from ailable starting materials. Hence, this route to the tetralones was via Rh(II) decomposition of precursor diazoketones. The synthesis of benzoquinazolines bus routes was relatively long, problematical and not cost effective. It was found of diazoketones with Rh(II) catalysis lead to the desired tetralones in e yields (Scheme 1). 1. Synthesis of tetralones
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29

Bandini, Elisa <1966&gt. "Biologically Active Compounds Via 2-Aza-1,3-Dienes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/476/1/PhD_Thesis_BANDINI_ELISA.pdf.

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30

Bandini, Elisa <1966&gt. "Biologically Active Compounds Via 2-Aza-1,3-Dienes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/476/.

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31

Deo, M. G. "Studies in biologically active compounds using chromatography techniques." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3268.

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32

Gharpure, M. M. "Synthesis of biologically active compounds and their analogues." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3307.

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33

Patil, V. J. "Synthesis of some biologically active compounds from carbohydrates." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3239.

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34

Askew, Stuart Clive. "Some studies of biologically active S-nitrosothiols." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/15189.

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S-nitrosothiols are effective NO-donating drugs which can elicit vasodilation of vascular tissue and disaggregate or inhibit the aggregation of platelets in blood. The chemistries of two S-nitrosothiols, S-nitroso-N-acetyl-DL-penicillamine (SNAP) and S-nitrosoglutathione (GSNO) have been investigated in an attempt to identify the chemical and physiological mechanisms which underlie their biological actions as vasodilators and modulators of platelet behaviour. Although SNAP and GSNO have been found to be susceptible to decomposition by similar chemical mechanisms, such as by thermal and photoch
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35

Martelli, Giulia <1990&gt. "Synthesis and biological potential of new active β-lactam based compounds". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8868/1/Martelli_Giulia_tesi.pdf.

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This thesis is divided in three main chapters and reports the research work performed during a three year-PhD programme under the supervision of Prof. Daria Giacomini. The main subject of this dissertation concerns the design and synthesis of new classes of monocyclic β-lactam compounds and their biological potential. β-lactams in fact are really evergreen bioactive molecules, primarily known for their efficiency as antibiotics, but more recently considered also for a great number of diverse activities. The search for novel active azetidinone compounds has been deeply studied and pioneered
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36

Begum, Lovely. "The synthesis of fluorinated analogues of biologically active compounds." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343327.

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37

MIERI, M. DE. "CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/148883.

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Biologically active compounds are usually polyfunctional molecules bearing one or more stereocenters. Enzyme catalyzed transformations are well suitable for their preparation since they act in a very mild and selective manner. The study of three selected biocatalyzed transformations has been the aim of my PhD researches. The first project, regards the development of an advantageous and mild method to selectively transform the 24-hydroxyl function of ascomycin, a 23-membered macrolactam, bearing two secondary alcoholic moieties bounded at position 24 and 32 of its macrocycle. This selective pro
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38

N, Dhawane A. "Synthetic studies towards camptothecin and other biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2010. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3731.

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39

Bhamare, N. K. "New methods for the synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3293.

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40

Witherington, Jason. "Novel synthetic methods enabling the construction of biologically active compounds." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386942.

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41

Wickens, Kristen M. "A search for biologically active compounds in Acacia (Mimosaceae) species." Thesis, Curtin University, 2003. http://hdl.handle.net/20.500.11937/1262.

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Indigenous Australians were also known to use plants for medicinal purposes. For thousands of years, Indigenous Australians have used native plants as a source of medicinal agents. Some tribes living in Central Australia still, to this day, prefer to use traditional medicines in favour of the more common and readily available western medicines. A number of plant species endemic to Australia are listed in various Aboriginal pharmacopoeias, with approximately one-third of those species belonging to two genera, Acacia and Eremophila. Of the 1100 recognised species of Acacia, approximately 900 occ
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42

Wickens, Kristen M. "A search for biologically active compounds in Acacia (Mimosaceae) species." Curtin University of Technology, Department of Environmental Biology, 2003. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=15212.

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Indigenous Australians were also known to use plants for medicinal purposes. For thousands of years, Indigenous Australians have used native plants as a source of medicinal agents. Some tribes living in Central Australia still, to this day, prefer to use traditional medicines in favour of the more common and readily available western medicines. A number of plant species endemic to Australia are listed in various Aboriginal pharmacopoeias, with approximately one-third of those species belonging to two genera, Acacia and Eremophila. Of the 1100 recognised species of Acacia, approximately 900 occ
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43

Mosconi, Elisa <1981&gt. "Stereoselective synthesis of heterocycles as intermediates of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3432/1/Mosconi_Elisa_tesi.pdf.

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The aim of this thesis was to investigate the synthesis of enantiomerically enriched heterocycles and dehydro-β-amino acid derivatives which can be used as scaffolds or intermediates of biologically active compounds, in particular as novel αvβ3 and α5β1 integrin ligands. The starting materials of all the compounds here synthesized are alkylideneacetoacetates. Alkylidene derivates are very usefull compounds, they are usually used as unsaturated electrophiles and they have the advantage of introducing different kind of functionality that may be further elaborated. In chapter 1, regio- and stere
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44

Mosconi, Elisa <1981&gt. "Stereoselective synthesis of heterocycles as intermediates of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3432/.

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The aim of this thesis was to investigate the synthesis of enantiomerically enriched heterocycles and dehydro-β-amino acid derivatives which can be used as scaffolds or intermediates of biologically active compounds, in particular as novel αvβ3 and α5β1 integrin ligands. The starting materials of all the compounds here synthesized are alkylideneacetoacetates. Alkylidene derivates are very usefull compounds, they are usually used as unsaturated electrophiles and they have the advantage of introducing different kind of functionality that may be further elaborated. In chapter 1, regio- and stere
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45

Reddy, P. S. "Synthesis of some biologically active compounds and some natural products." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3261.

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46

Boukes, Gerhardt Johannes. "The in vitro biological activities of three Hypoxis species and their active compounds." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1228.

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The African potato is used as an African traditional medicine for its nutritional and medicinal properties. Most research has been carried out on H. hemerocallidea, with very little or nothing on other Hypoxis spp. The main aim of this project was to provide scientific data on the anticancer, anti-inflammatory and antioxidant properties of H. hemerocallidea, H. stellipilis and H. sobolifera chloroform extracts and their active compounds. The hypoxoside and phytosterol contents of the three Hypoxis spp. were determined using TLC, HPLC and GC. H. hemerocallidea and H. sobolifera chloroform extra
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47

D’Aurizio, Antonio <1978&gt. "Microwave-Mediated Hetero Diels-Alder reaction: Synthesis of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1641/1/D%27Aurizio_Antonio_Tesi.pdf.

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Heterocyclic compounds represent almost two-thirds of all the known organic compounds: they are widely distributed in nature and play a key role in a huge number of biologically important molecules including some of the most significant for human beings. A powerful tool for the synthesis of such compounds is the hetero Diels-Alder reaction (HDA), that involve a [4+2] cycloaddition reaction between heterodienes and suitable dienophiles. Among heterodienes to be used in such six-membered heterocyclic construction strategy, 3-trialkylsilyloxy-2-aza-1,3-dienes (Fig 1) has been demonstrated parti
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48

D’Aurizio, Antonio <1978&gt. "Microwave-Mediated Hetero Diels-Alder reaction: Synthesis of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1641/.

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Heterocyclic compounds represent almost two-thirds of all the known organic compounds: they are widely distributed in nature and play a key role in a huge number of biologically important molecules including some of the most significant for human beings. A powerful tool for the synthesis of such compounds is the hetero Diels-Alder reaction (HDA), that involve a [4+2] cycloaddition reaction between heterodienes and suitable dienophiles. Among heterodienes to be used in such six-membered heterocyclic construction strategy, 3-trialkylsilyloxy-2-aza-1,3-dienes (Fig 1) has been demonstrated parti
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49

Pathak, A. B. "Synthetic studies towards camptothecin, its analogues and other biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2637.

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50

Sivappa, R. "Total synthesis of camptothecin and its analogues and biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2002. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2858.

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