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Dissertations / Theses on the topic 'Biological basis'

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1

Sugarman, Franz. "The biological basis of schizophrenia /." Online version of thesis, 1991. http://hdl.handle.net/1850/11644.

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Wickett, John C. "The biological basis of general intelligence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28528.pdf.

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3

Brookner, Carrie Kazinoff. "Biological basis of cervical tissue autofluorescence /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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4

Camfield, David Alan. "The biological basis of openness to experience." Swinburne Research Bank, 2008. http://hdl.handle.net/1959.3/49815.

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Thesis (PhD) - Swinburne University of Technology, Brain Sciences Institute, 2008.<br>[A thesis submitted for the degree of] Doctor of Philosophy, Brain Sciences Institute, Swinburne University of Technology - 2008. Typescript. Includes bibliographical references (p. 250-272) and index.
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Jokisch, Daniel. "The neuropsychological basis of perception of biological motion." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97349638X.

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Erickson, Cynthia Ann. "Brain and behavior: Searching for the biological basis of learning." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186534.

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The hippocampus is a brain structure known to be important for learning and memory, more specifically for the acquisition of spatial information. Hebb (1940) suggested that storage of information in the brain may involve modifications in the strength of synaptic connections. One example of an artificially-induced synaptic alteration that may share common mechanisms with memory formation is long-term synaptic enhancement (LTE). Recently, behaviorally-induced changes in hippocampal synapses have been discovered to occur in conjunction with exploratory behavior. This type of change has been calle
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Gu, Chen Ph D. Massachusetts Institute of Technology. "The molecular basis for tumor growth suppression by tRNA methyltransferase 9-like (TRM9L)." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112512.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The human tRNA methyltransferase 9-like (TRM9L) gene is a homolog of yeast Trm9 and human ALKBH8 and it has an important function in suppressing tumor growth in colorectal cancer. Loss of heterozygosity events on the Chromosome 8p22 loci, where TRM9L is located, are overrepresented in a wide variety of cancers, including prostate cancer, breast carcinoma, and hepatocellular carcinoma; downregulation of TRM9L expre
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Bashir, Amreen. "Exploring the biological basis for Salmonella persistence in food manufacturing environments." Thesis, Aston University, 2016. http://publications.aston.ac.uk/28847/.

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The persistence of Salmonella spp. in low moisture foods is a challenge for the food industry as despite control strategies already in place, notable outbreaks still occur. The aim of this study was to characterise isolates of Salmonella, known to be persistent in the food manufacturing environment, by comparing their microbiological characteristics with a panel of matched clinical and veterinary isolates. The gross morphology of the challenge panel was phenotypically characterised in terms of cellular size, shape and motility. In all the parameters measured, the factory isolates were indistin
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Alhaj-Hussein, Baraa Tajuddin. "Investigating the biological and genetic basis in 'Helicobacter pylori' biofilm formation." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558365.

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Cowling, Jenny Elizabeth. "Physiological basis for biological invasion : the terrestrial amphipod Arcitalitrus dorrieni Hunt 1925." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247178.

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Burkhart, Jessica Cheri, Chelsea Takamatsu, Daniel Gray, and Carol A. Barnes. "Understanding the Biological Basis of Cognitive Aging: The Role of Inhibitory Interneurons." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/578894.

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Previous studies reveal decreases in hippocampal interneuron cell densities during normal aging. However, considerable variation in results exists within the literature. Overall, interneuron populations show either decreases or conservation in cell numbers expressing calcium binding proteins parvalbumin (PV) and calbindin (CB), and neuropeptides somatostatin (SOM) and neuropeptite Y (NPY) in hippocampal subregions of CA1, CA3, dentate granule cell layer, and dentate hilus. Notably, only few of the past aging studies showed correlations in cell loss with behavioral impairments in aged animals.
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Barcelo, Batllori Silvia Barcelo. "Synthesis of sulforaphane and inhibition of cytochrome P450 enzymes as a basis for antigenotoxicity." Thesis, Aston University, 1997. http://publications.aston.ac.uk/15677/.

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Sulforaphane was synthesised with an overall yield of 15%, essentially via 1-methylsulfinylphthalimidobutane, which was oxidised to the sulfoxide moiety. Sulforaphane was a competitive inhibitor of CYPO2E1 in acetone-induced Sprague-Dawley rat microsomes (Ki 37.9 4.5 M), as measured by the p-nitrophenol hydroxylase assay. Ethoxyresorufin deethylase activity (EROD), a measurement of CYP1A activity, was also inhibited by sulforaphane (100 M) but was not competitive, and a preincubation time-dependence was observed. In view of these results, the capacity of sulforaphane to inhibit N-nitrosodimeth
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13

Ellis, Richard John. "Basis for the biocontrol of Pythium by fluorescent pseudomonads." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:980ebd0a-5cd5-4408-858e-55e184e8566a.

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The aim of this thesis was to gain an understanding of the molecular and ecological basis for the biological control of Pythium by fluorescent pseudomonads. A fluorescent pseudomonad biocontrol agent (BCA), Pseudomonas fluorescens 54/96, identified as a potential candidate for commercial development, was analysed together with transposon induced mutants in a variety of assays for anti-fungal activity (Chapter 2). It was revealed that 54/96 had a fungistatic effect generated by a number of different mechanisms, which included nutrient competition and antibiosis. The synecology of this organism
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Andorf, Sandra. "A systems biological approach towards the molecular basis of heterosis in Arabidopsis thaliana." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5117/.

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Heterosis is defined as the superiority in performance of heterozygous genotypes compared to their corresponding genetically different homozygous parents. This phenomenon is already known since the beginning of the last century and it has been widely used in plant breeding, but the underlying genetic and molecular mechanisms are not well understood. In this work, a systems biological approach based on molecular network structures is proposed to contribute to the understanding of heterosis. Hybrids are likely to contain additional regulatory possibilities compared to their homozygous parents an
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Le, Yevgeniya. "Immunocamouflage : the biophysical and biological basis of immunoprotection by grafted methoxypoly(ethylene glycol)." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/20562.

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Development of novel approaches for the direct immunomodulation of allogeneic donor cells would have significant utility in tissue transplantation. Immunocamouflage of cell surfaces by covalently grafted methoxypoly(ethylene glycol) (mPEG; PEGylation) has emerged as a promising approach. While previous studies demonstrated the in vitro and in vivo efficacy of immunocamouflaged allogeneic cells and viruses, the biophysical mechanisms of immunoprotection have not been well-defined due to the labile nature of biological samples. To overcome this limitation, polystyrene latex particles (1.2 and
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Stevenson, Leonard. "A molecular basis for the biological control activity of a pseudomonas fluorescens strain." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240424.

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17

Lau, Johnny King Lam. "The neural basis of object perception : dissociating action and semantic processing." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6811/.

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This thesis has evaluated the roles of dorsal and ventral processing streams in recognition and use of objects. Four main empirical studies are presented. First, to investigate how the cortical brain processes semantic and action knowledge in different object-related tasks, I examined structural data from stroke patients (Chapter 2) and functional data from healthy individuals (Chapter 3) using a voxel-wise statistical analysis method. Using data of different modalities (structural CT, fMRI) from different sources (patients’ lesions; healthy subjects’ functional activity) handled with a system
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Wijeyekoon, Ruwani Shamila. "The biological basis of heterogeneity in Parkinson's disease : insights from an innate immune perspective." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283202.

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The biological basis of the clinical heterogeneity in Parkinson's Disease (PD) is unclear. It is likely to involve complex interactions between genetic and environmental factors and between a range of pathological processes, including protein homeostasis and immune system function. Microglial activation in the brain and peripheral innate immune changes are known to occur in PD. Recently genetic, animal and cellular studies have linked several innate immune related genes and proteins (e.g. HLADR, TREM2, TLR2, TLR4, caspase-1) to PD and provided evidence that they may have a role in PD pathogene
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Khan, Tahmina. "Investigation of the biological and chemical basis underpinning contact lens solution induced corneal staining." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-the-biological-and-chemical-basis-underpinning-contact-lens-solution-induced-corneal-staining(3d84a7c2-54d9-4c8f-92ad-4d4fa6134c07).html.

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Purpose: Sodium fluorescein ('fluorescein') is the most commonly used diagnostic ophthalmic dye for clinical assessment of the ocular surface. An increase in fluorescein staining presents after the use of certain multi-purpose solutions (MPS) and contact lenses, which is a clinical phenomenon known as solution induced corneal staining (SICS). The clinical relevance and mechanisms underpinning fluorescein staining however is conflicting in the literature. Currently a number of studies indicate fluorescein localises within cells that are healthy and metabolically active, in contrast to conventio
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Grano, Maldonado Mayra Ixchel. "The biological and behavioural basis of host selection in the transmission of Gyrodactylus (Monogenea)." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/3700.

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The ectoparasitic monogenean fluke, Gyrodactylus salaris, is a parasite known to be highly pathogenic to Atlantic salmon (Salmo salar). Although present in the environment of several neighbouring European countries, the UK is thought to be G. salaris-free, but, if national contingency plans to control this parasite are to be effective, it is vital that we understand the factors underlying its transmission from host to host. This study demonstrates that the majority of parasites transferring to new hosts are mature parasites that have reproduced at least once. Since, exploration and host transf
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Hidayat, Egi. "On Identification of Biological Systems." Doctoral thesis, Uppsala universitet, Avdelningen för systemteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215699.

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System identification finds nowadays application in various areas of biological research as a tool of empiric mathematical modeling and model individualization. A fundamental challenge of system identification in biology awaits in the form of response variability. Furthermore, biological systems tend to exhibit high degree of nonlinearity as well as significant time delays. This thesis covers system identification approaches developed for the applications within two particular biomedical fields: neuroscience and endocrinology. The first topic of the thesis is parameter estimation of the classi
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Barbany, Puig Montserrat. "Three Dimensional Simulitary of Molecules with biological interest on the basis of molecular interaction potentials." Doctoral thesis, Universitat Pompeu Fabra, 2006. http://hdl.handle.net/10803/7146.

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Una de les àrees més prometedores en recerca biomèdica i farmacèutica és el disseny molecular computacional, que intenta establir relacions entre propietats físico-químiques i activitat biològica. <br/>L'èxit d'aquestes tècniques depen críticament de la qualitat de la descripció molecular. En aquest sentit, metodologies basades en potencials d'interacció molecular (MIP) són eines útils per la comparació de compostos que presenten comportaments biològics semblants. <br/>Aquest projecte desenvolupa eines per comparar molècules basades en la caracterització de llurs MIPs. El programa de similarit
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23

Ghezzo, Alessandro <1962&gt. "The biological basis of autism spectrum disorders: evaluation of oxidative stress and erytrocyte membrane alterations." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7116/1/Ghezzo_Alessandro_tesi.pdf.

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This case-control study involved a total of 29 autistic children (Au) aged 6 to 12 years, and 28 gender and age-matched typically developing children (TD). We evaluated a high number of peripheral oxidative stress parameters, erythrocyte and lymphocyte membrane functional features and membrane lipid composition of erythrocyte. Erythrocyte TBARS, Peroxiredoxin II, Protein Carbonyl Groups and urinary HEL and isoprostane levels were elevated in AU (confirming an imbalance of the redox status of Au); other oxidative stress markers or associated parameters (urinary 8-oxo-dG, plasma Total antioxid
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Ghezzo, Alessandro <1962&gt. "The biological basis of autism spectrum disorders: evaluation of oxidative stress and erytrocyte membrane alterations." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7116/.

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This case-control study involved a total of 29 autistic children (Au) aged 6 to 12 years, and 28 gender and age-matched typically developing children (TD). We evaluated a high number of peripheral oxidative stress parameters, erythrocyte and lymphocyte membrane functional features and membrane lipid composition of erythrocyte. Erythrocyte TBARS, Peroxiredoxin II, Protein Carbonyl Groups and urinary HEL and isoprostane levels were elevated in AU (confirming an imbalance of the redox status of Au); other oxidative stress markers or associated parameters (urinary 8-oxo-dG, plasma Total antioxid
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Chittum, Harold S. "A Molecular Basis for Erythromycin Sensitivity and Resistance in Escherichia Coli." Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2655.

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The effect of erythromycin on the 50S ribosomal subunit during cell growth has been extensively investigated. Sucrose density gradient analysis of ribosomes formed in the presence and absence of the drug revealed a 50S specific assembly defect is partially responsible for erythromycin's inhibitory effects on wild type cells. Examination of two erythromycin-resistant mutants of E. coli (N281 and N282) revealed that mutant N281 (L22 mutant) but not N282 (L4 mutant) was assembly defective in the presence of the drug, although only at much higher drug concentrations (300 ug/ml vs. 75 ug/ml for wil
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Kurniawan, Veldri. "The neural basis of multisensory spatial and feature-based attention in vision and somatosensation." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/40755/.

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Attention refers to the cognitive processes that prioritise a subset of available sensory information for enhanced processing, and which can be directed towards spatial locations, object features, time, or other aspects of the environment. While the majority of research has focused on studying attention within sensory modalities, a growing body of evidence has demonstrated that attention interact with multisensory processes. Several neuroimaging studies have shown that higher cortical regions activated during attention to multiple sensory modalities overlap significantly with the dorsal and ve
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Masureel, Matthieu. "Molecular basis of secondary multidrug transport." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209479.

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The Major Facilitator Superfamily groups a vast number of secondary transporters that import or export distinct substrates. Among these, multidrug antiporters constitute a peculiar class of transporters, both because of their multispecificity, recognizing structurally very diverse substrates, and because of their transport mechanism, that relies on bilayer-mediated extrusion of cytotoxic compounds. An accurate and detailed description of the conformational changes that underlie the transport cycle is still lacking and the structural basis for energetic coupling in these transporters has not be
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Ross, Graham Andrew. "An investigation into the biological basis of #late effect' endpoints in the rectum of rats after radiation." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339103.

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Ford, Eleanora. "Mechanisms of reactions of nitrogen oxides with biological molecules and the chemical basis for cellular nitrosative stress." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367737.

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Scuridin, V. S., E. A. Nesterov, A. S. Rogov, V. L. Sadkin, and N. V. Varlamova. "Production and Medical-Biological Tests of Nanocolloids on the Basis of Aluminum Oxide Labeled by Technetium-99m." Thesis, Sumy State University, 2012. http://essuir.sumdu.edu.ua/handle/123456789/34933.

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The authors have studied regularities of adsorption of 99mTc (VII) on the activated gamma-oxide, Al2O3. It has been shown that the sorption capacity of the oxide on the radionuclide depends on its acid treatment. Technetium-99m recovery process in the presence of stannous Sn (II) with the aim to determine it is necessary and sufficient quantity, that would provide a complete "recovery" of 99mTc in the reaction mixture has been investigated. The adsorption process of the restored 99mTs on the nanoscale powder of gammaaluminum oxide has been studied, and the method of obtaining nanocolloids
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Sbragaglia, Valerio. "Biological rhythms in the Norway lobster (Nephrops Norvegicus L.) : Ecological modulation and genetic basis = Ritmos biológicos en la cigala (Nephrops norvegicus L.) : modulación ecológica y bases genéticas." Doctoral thesis, Universitat Politècnica de Catalunya, 2015. http://hdl.handle.net/10803/318164.

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Nephrops norvegicus is an important fishery resource for Europe. Its rhythmic burrowing behavior is strictly related to catchability. Here I studied such behavior under laboratory conditions. I investigated the combined effect of light and current cycles demonstrating that tidal current is an important parameter to take in account in fishery management plan not only for Nephrops. Then I used a transcriptomics and RT-qPCR approach on cDNA extracted from the eyestalk to elucidate the putative molecular genetics mechanisms underlying circadian gene regulation. My data are in accordance with the c
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Farrell, Katrina. "The biological basis and clinical correlates of the association between EBV-positive Hodgkin lymphoma and HLA class I." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4900/.

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Classical Hodgkin lymphoma (cHL) is one of the commonest lymphomas in the developed world, frequently affecting young adults. The majority of patients will be cured of their disease, but the toxicities of the therapy required to achieve this can lead to long-term morbidity in survivors. In addition, whilst most patients are cured, there remains approximately 15% -20% of patients who will not respond to primary therapy and may ultimately die of their disease. Approximately one-third of cases of cHL in the developed world are associated with the Epstein-Barr virus (EBV), where this association i
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Miao, Kai. "Microcirculation: Electrophysiological Basis for the Response of Endothelial Cells to Inflammatory Mediators-bradykinin." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etd/2749.

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Using conventional microelectrodes, I studied the electrical basis for determining the resting V$\sb{\rm m}$ in intact EC's from hamsters. The resting V$\sb{\rm m}$ were found to be $-$40 mV for aortic EC's and $-$43 mV for vena caval EC's. The contributions of ions to the resting V$\sb{\rm m}$ of aortic EC's were compared in terms of the transference number (t$\sb{\rm ion}$). To develop a technique for in situ monitoring changes in V$\sb{\rm m}$ of postcapillary venular EC's in the hamster mesentery, a voltage-sensitive fluorescent probe, bisoxonol, was used to load the cells and the fluoresc
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Beteta, Pacheco Edmundo. "The psychophisiology and the development of clinic psychology." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/99911.

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Up to date anatomical and biochemistry studies related to Brain mechanisms of behavior are reviewed. This type of research shold be work up in clinical psychology related to prevention, diagnostic and therapy of behavior disorders. In this way, the clinical psychology should make clinical research at differents age groups of the population. He will be able to study epidemiological risk factors together with neuropsychologycal tests and Brain imagind studies.<br>Se presentan los avances en Psicofisiología, destacando los estudios anatómicos y bioquímicos de los mecanismos cerebrales que intervi
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Wessling-Resnick, Marianne. "Molecular Basis of the Mechanism and Regulation of Receptor-GTP Binding Protein Interactions: A Thesis." eScholarship@UMMS, 1997. https://escholarship.umassmed.edu/gsbs_diss/100.

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The photon receptor, rhodopsin, and the GTP-binding regulatory protein, transducin, belong to a family of G protein-coupled receptors. The activation process through which guanine nucleotide exchange of the G protein is accomplished was investigated utilizing these components of the visual transduction system. Rhodopsin, modelled as an enzyme in its interaction with substrates, transducin and guanine nucleotides, was characterized to catalyze the G protein's activation by a double-displacement mechanism. Remarkable allosteric behavior was observed in these kinetic studies. Equilibrium binding
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Bugila, Abdalbaset Abusalah Ali. "Host-parasitoid relationships of Anagyrus sp. near pseudococci (Girault), (Hymenoptera, Encyrtidae), as a basis to improve biological control of pest mealybugs (Hemiptera, Pseudococcidae)." Doctoral thesis, ISA/UL, 2014. http://hdl.handle.net/10400.5/7341.

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Doutoramento em Engenharia Agronómica - Instituto Superior de Agronomia<br>The host-parasitoid relationships of Anagyrus sp. nr. pseudococci were investigated, including host selection behavior, host defenses, host suitability and parasitoid functional response in relation to five mealybug species with different phylogenetic relationships and geographical origins: i) a Mediterranean native species, Planococcus ficus, with a long co-evolutionary history with the parasitoid; ii) three alien species, Planococcus citri, Pseudococcus calceolariae and Pseudococcus viburni, with a more recent co
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Schanz, Johanna E. "Etablierung einer biologischen vaskularisierten Matrix als Grundlage für ein in vitro Lebertestsystem Establishment of a biological vascularized scaffold as a basis for in vitro liver test system /." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34146.

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Cowley, Lauren A. "Use of genome sequencing to investigate the molecular basis of bacteriaphage interaction of the Escherichia coli O157 typing phages and the elucidation of the biological and public health significance of phage type." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23583.

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Background Shiga toxin producing Escherichia coli (STEC) O157 causes severe gastrointestinal disease and haemolytic uremic syndrome, and has a major impact on public health worldwide with regular outbreaks and sporadic infection. Phage typing, i.e. the susceptibility of STEC O157 strains to a bank of 16 bacteriophages, has been used in the UK to differentiate STEC O157 for the past 25 years and the phage type (PT) can be an epidemiological marker of strains associated with severe disease or associated with cases that occur from foreign travel. However, little is known about the molecular inter
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Knaack, Sven. "Entwicklung und Charakterisierung von Scaffolds auf Basis von mineralisiertem Kollagen zur gezielten Wirkstofffreisetzung für die Knochengewebe-Regeneration." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-188547.

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Beim Tissue Engineering ist die Vaskularisierung von größeren Zell-Matrix-Konstrukten nach Implantation bis heute ein großes Problem. Durch das initiale Fehlen eines mikrovaskulären Netzwerkes kommt es zu einem raschen Zellsterben im Scaffold. Aufgrund dessen war das Ziel dieser Arbeit, im Sinne des in situ-Tissue Engineering ein Scaffold auf Basis von mineralisiertem Kollagen zu entwickeln, welches mit dem angiogenen Wachstumsfaktor VEGF funktionalisiert wird, um den Prozess der Vaskularisierung – die Einsprossung von Blutgefäßen – zu fördern und gleichzeitig durch Chemoattraktion in vivo Z
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Frizzo, Matias Nunes. "Avalia??o das bases biol?gicas e sociais do temperamento." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2013. http://tede2.pucrs.br/tede2/handle/tede/5463.

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Made available in DSpace on 2015-04-14T14:51:25Z (GMT). No. of bitstreams: 1 448546.pdf: 1722481 bytes, checksum: a40adfe8bfc8e436fd504a30736f22aa (MD5) Previous issue date: 2013-02-08<br>Temperament can be regarded as the basis of mood, behavior and personality. It has a strong biological basis, manifested early in the development of the individual, guiding the formation of habits and is relatively stable over time. Although it is known that there are environmental influences, the relationship of temperament with biological markers and social environment is not well defined. Evidence sugges
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Bauer-Mehren, Anna. "Integrative approaches to investigate the molecular basis of diseases and adverse drug reactions: from multivariate statistical analysis to systems biology." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7219.

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Despite some great success, many human diseases cannot be effectively treated, prevented or cured, yet. Moreover, prescribed drugs are often not very efficient and cause undesired side effects. Hence, there is a need to investigate the molecular basis of diseases and adverse drug reactions in more detail. For this purpose, relevant biomedical data needs to be gathered, integrated and analysed in a meaningful way. In this regard, we have developed novel integrative analysis approaches based on both perspectives, classical multivariate statistics and systems biology. A novel multilevel statistic
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Bueno, Nádia Maebara [UNESP]. "Bases biológicas para utilização de Trichospilus diatraeae (Hymenoptera: Eulophidae) para controle de Helicoverpa armigera (Lepidoptera: Noctuidae)." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/131920.

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Made available in DSpace on 2015-12-10T14:22:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-23. Added 1 bitstream(s) on 2015-12-10T14:28:41Z : No. of bitstreams: 1 000853174.pdf: 327916 bytes, checksum: 8b80e5d10c5f87704a801b1cac7b55a1 (MD5)<br>A espécie Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) é um inseto polífago, com ampla distribuição geográfica e considerada uma importante praga nas regiões do mundo em que ocorre. Na safra 2013/2014, a presença desse lepidóptero foi registrada pela primeira vez no Brasil, acarretando em perdas de produtividade. Essa espécie pos
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Bueno, Nádia Maebara 1988. "Bases biológicas para utilização de Trichospilus diatraeae (Hymenoptera: Eulophidae) para controle de Helicoverpa armigera (Lepidoptera: Noctuidae) /." Botucatu, 2015. http://hdl.handle.net/11449/131920.

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Orientador: Regiane Cristina Oliveira de Freitas Bueno<br>Coorientador: Carlos Frederico Wilcken<br>Banca:Everton Pires Soliman<br>Banca: Valmir Antonio Costa<br>Resumo: A espécie Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) é um inseto polífago, com ampla distribuição geográfica e considerada uma importante praga nas regiões do mundo em que ocorre. Na safra 2013/2014, a presença desse lepidóptero foi registrada pela primeira vez no Brasil, acarretando em perdas de produtividade. Essa espécie possui diversas características que a tornam de indiscutível importância, como o fato de dispe
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Anderson, Kalin A. "Implicit models of the biological bases of weight loss." CSUSB ScholarWorks, 1988. https://scholarworks.lib.csusb.edu/etd-project/341.

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45

Jaskulski, L?ia. "Liga??o do dom?nio Ets de ESE-3 ? sequ?ncia de DNA contendo as bases centrais 5 -GGAX-3 (X= A ou T) : an?lises cin?ticas e em equil?brio estimadas por resson?ncia plasm?nica de superf?cie." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2009. http://tede2.pucrs.br/tede2/handle/tede/5347.

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Made available in DSpace on 2015-04-14T14:50:56Z (GMT). No. of bitstreams: 1 412868.pdf: 709463 bytes, checksum: 24e54fc3c08be35252a751617c52ca4d (MD5) Previous issue date: 2009-04-02<br>Tem se mostrado que a prote?na ESE-3 (Fator espec?fico de epit?lio, do ingl?s epithelium-specific Ets factor, family member 3) desempenha importantes pap?is na determina??o do destino inicial da diferencia??o do epit?lio escamoso estratificado, na indu??o da express?o do receptor para um ligante que induz ? apoptose, relacionado com necrose tumoral, e em processos inflamat?rios de doen?as respirat?rias, tais
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Rocha, Helder Henrique Ribeiro. "The genetic basis of lifespan in Drosophila americana." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10080.

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Mestrado em Biologia Molecular e Celular<br>A compreensão da base molecular da variação fenotípica observada dentro e entre espécies, como acontece na longevidade, é um dos principais objetivos da Biologia. Em Drosophila melanogaster foram já identificados mais de 50 genes que podem contribuir para a definição do tempo de vida. Contudo, na maioria dos estudos, as conclusões são baseadas em mutações criadas artificialmente noa genes alvo. Desta forma, é improvável que o tipo de variação observada exista em populações naturais, e como tal não se encontra totalmente esclarecido se variação nestes
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Doucet, Cynthia. "On the biological bases of extraversion, sensory and motor considerations." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0012/NQ38781.pdf.

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Noatch, Matthew R. "An Evaluation of Chemical, Biological, and Combined Chemical-Biological Approaches for Controlling Snails in Aquaculture Ponds." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/198.

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Digenetic trematodes are a common pest problem in aquaculture where their unappetizing appearance often reduces the marketability of food fish. Aquatic snails are intermediate hosts in the trematode lifecycle and are commonly targeted with control measures to prevent the crop fish from becoming infected. I evaluated several chemical and biological snail control strategies as alternatives to the potentially invasive black carp. Copper sulfate, hydrated lime slurry, and several fish and decapod species were tested for effectiveness against physid (Physa spp.) and planorbid (Helisoma spp.) snails
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Rosa, Annachiara. "The cellular and molecular basis of the Nef requirement for HIV-1 infectivity." Doctoral thesis, Università degli studi di Trento, 2016. https://hdl.handle.net/11572/369203.

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Nef is an HIV -1 accessory protein with a fundamental role for virus replication in vivo and for the development of AIDS. Among its several activities, Nef is essential for full HIV-1 infectivity, a function highly prominent in lymphoid cells. So far, the mechanism by which Nef promotes HIV-1 infectivity has remained elusive. Over the course of 3 years, my PhD research activity has led to the identification of the host transmembrane protein SERINC5, and to a lesser extent SERINC3, as potent inhibitors of HIV-1 infectivity counteracted by the viral protein Nef [Rosa et al., 2015]. SERINC5 is pr
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Clark, Daniel G. "Physical and biological sources and sinks of nitrate in the Canary basin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq24817.pdf.

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