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Journal articles on the topic 'Biological cell manipulation'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

Gertz, Frederick, and Alexander Khitun. "Biological cell manipulation by magnetic nanoparticles." AIP Advances 6, no. 2 (2016): 025308. http://dx.doi.org/10.1063/1.4942090.

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2

Grad, Michael, Alan W. Bigelow, Guy Garty, Daniel Attinger, and David J. Brenner. "Optofluidic cell manipulation for a biological microbeam." Review of Scientific Instruments 84, no. 1 (2013): 014301. http://dx.doi.org/10.1063/1.4774043.

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3

Liu, Xing, and Xiaolin Zheng. "Microfluidic-Based Electrical Operation and Measurement Methods in Single-Cell Analysis." Sensors 24, no. 19 (2024): 6359. http://dx.doi.org/10.3390/s24196359.

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Cellular heterogeneity plays a significant role in understanding biological processes, such as cell cycle and disease progression. Microfluidics has emerged as a versatile tool for manipulating single cells and analyzing their heterogeneity with the merits of precise fluid control, small sample consumption, easy integration, and high throughput. Specifically, integrating microfluidics with electrical techniques provides a rapid, label-free, and non-invasive way to investigate cellular heterogeneity at the single-cell level. Here, we review the recent development of microfluidic-based electrica

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Choi, Charles, and Michael N. Nitabach. "Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits." Physiology 28, no. 3 (2013): 164–71. http://dx.doi.org/10.1152/physiol.00056.2012.

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Detection of secreted signaling molecules by cognate cell surface receptors is a major intercellular communication pathway in cellular circuits that control biological processes. Understanding the biological significance of these connections would allow us to understand how cellular circuits operate as a whole. Membrane-tethered ligands are recombinant transgenes with structural modules that allow them to act on cell-surface receptors and ion channel subtypes with pharmacological specificity in a cell-autonomous manner. Membrane-tethered ligands have been successful in the specific manipulatio

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5

Shishkin, Ivan, Hen Markovich, Yael Roichman, and Pavel Ginzburg. "Auxiliary Optomechanical Tools for 3D Cell Manipulation." Micromachines 11, no. 1 (2020): 90. http://dx.doi.org/10.3390/mi11010090.

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Advances in laser and optoelectronic technologies have brought the general concept of optomechanical manipulation to the level of standard biophysical tools, paving the way towards controlled experiments and measurements of tiny mechanical forces. Recent developments in direct laser writing (DLW) have enabled the realization of new types of micron-scale optomechanical tools, capable of performing designated functions. Here we further develop the concept of DLW-fabricated optomechanically-driven tools and demonstrate full-3D manipulation capabilities over biological objects. In particular, we r

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Hu, Songyu, and Dong Sun. "Automatic transportation of biological cells with a robot-tweezer manipulation system." International Journal of Robotics Research 30, no. 14 (2011): 1681–94. http://dx.doi.org/10.1177/0278364911413479.

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The positioning of biological cells has become increasingly important in biomedical research such as drug discovery, cell-to-cell interaction, and tissue engineering. Significant demand for both accuracy and productivity in cell manipulation highlights the need for automated cell transportation with integrated robotics and micro/nano-manipulation technologies. Optical tweezers, which use highly focused low-power laser beams to trap and manipulate particles at the micro/nanoscale, can be treated as special robot ‘end-effectors’ to manipulate biological objects in a noninvasive way. In this pape

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Fukuda, Toshio, and Kenji Inoue. "Special Issue on System Cell Engineering by Multiscale Manipulation." Journal of Robotics and Mechatronics 19, no. 5 (2007): 499. http://dx.doi.org/10.20965/jrm.2007.p0499.

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Recent advancements in micro/nano robotics and mechatronics technology have contributed to the discovery of new scientific knowledge in bioscience and the development of new treatments and examinations in medical fields. To promote interdisciplinary research among the engineering, biological, and medical fields and to promote further progress in these fields, Scientific Research on Priority Areas, ""System Cell Engineering by Multiscale Manipulation (Head Investigator: Toshio Fukuda),"" was begun in 2005. In this research area, we study system cell engineering seeking an understanding of commu

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8

Huang, Chen-Yu, Teng-Fu Hsieh, Wei-Chieh Chang, et al. "Magnetic Micro/Nano Structures for Biological Manipulation." SPIN 06, no. 01 (2016): 1650005. http://dx.doi.org/10.1142/s2010324716500053.

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Biomanipulation based on micro/nano structures is an attractive approach for biotechnology. To manipulate biological systems by magnetic forces, the magnetic labeling technology utilized magnetic nanoparticles (MNPs) as a common rule. Ferrofluid, well-dispersed MNPs, can be used for magnetic modification of the surface or as molds to form organized microstructures. For magnetic-based micro/nano structures, different methods to modulate magnetic field at the microscale have been developed. Specifically, this review focused on a new strategy which uses the concept of micromagnetism of patterned

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9

Nagai, Y. "S13.1 Manipulation of glycolipids in the cell and its cell biological consequences." Glycoconjugate Journal 10, no. 4 (1993): 304. http://dx.doi.org/10.1007/bf01210063.

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10

Yan, Songyuan, Zarya Rajestari, Timothy Clifford Morse, Harbour Li, and Lawrence Kulinsky. "Electrokinetic Manipulation of Biological Cells towards Biotechnology Applications." Micromachines 15, no. 3 (2024): 341. http://dx.doi.org/10.3390/mi15030341.

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The presented study demonstrates the capability of the template-based electrokinetic assembly (TEA) and guidance to manipulate and capture individual biological cells within a microfluidic platform. Specifically, dielectrophoretic (DEP) focusing of K-562 cells towards lithographically-defined “wells” on the microelectrodes and positioning singles cells withing these “wells” was demonstrated. K-562 lymphoblast cells, are widely used in immunology research. The DEP guidance, particularly involving positive DEP (pDEP), enables the controlled guidance and positioning of conductive and dielectric p

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11

Arai, Fumihito, Toshiaki Endo, Ryuji Yamauchi, and Toshio Fukuda. "3D 6DOF Manipulation of Microbead by Laser Tweezers." Journal of Robotics and Mechatronics 18, no. 2 (2006): 153–59. http://dx.doi.org/10.20965/jrm.2006.p0153.

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Laser tweezers are suitable for manipulation of a single microscopic biological object. It can manipulate micro bio-object by noncontact in closed space. Single cell manipulation is important for biological research works, and 3D 6DOF manipulation (Position control and Orientation control) is useful technique in many biological experiments. Here we proposed 3D synchronized laser manipulation system by which we can manipulate multiple micro-objects along each designed trajectory in 3D space. Position and orientation of microbeads can be controlled by the newly developed 3D synchronized laser mi

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12

Hu, Songyu, Heng Xie, Tanyong Wei, Shuxun Chen, and Dong Sun. "Automated Indirect Transportation of Biological Cells with Optical Tweezers and a 3D Printed Microtool." Applied Sciences 9, no. 14 (2019): 2883. http://dx.doi.org/10.3390/app9142883.

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Optical tweezers are widely used for noninvasive and precise micromanipulation of living cells to understand biological processes. By focusing laser beams on cells, direct cell manipulation with optical tweezers can achieve high precision and flexibility. However, direct exposure to the laser beam can lead to negative effects on the cells. These phenomena are also known as photobleaching and photodamage. In this study, we proposed a new indirect cell micromanipulation approach combined with a robot-aided holographic optical tweezer system and 3D nano-printed microtool. The microtool was design

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13

Luo, Tao, Lei Fan, Rong Zhu, and Dong Sun. "Microfluidic Single-Cell Manipulation and Analysis: Methods and Applications." Micromachines 10, no. 2 (2019): 104. http://dx.doi.org/10.3390/mi10020104.

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In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a genetically identical group are the same. This heterogeneity at the single-cell level has been recognized to be vital for the correct interpretation of diagnostic and therapeutic results of diseases, but has been masked for a long time by studying average responses from a population. To comprehensively understand cell heterogeneity, diverse manipulation and comprehensive analysis of cells at the single-cell level are demanded. However, using traditional biological tools, such as petri-dishes and well

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Fukuda, Toshio, Kenji Inoue, and Shoji Maruo. "Special Issue on Advances in System Cell Engineering by Multiscale Manipulation." Journal of Robotics and Mechatronics 22, no. 5 (2010): 567. http://dx.doi.org/10.20965/jrm.2010.p0567.

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Recent advances in micro- and nano-robotics and mechatronics have led to the discovery of new bioscientific knowledge and the development of new methods of medical treatments and examinations. Scientific Research on Priority Areas, “System Cell Engineering by Multiscale Manipulation” (Head Investigator: Toshio Fukuda), was begun in 2005 to promote interdisciplinary research among engineering, biological, and medical fields and to promote progress in these fields. System cell engineering seeks to understand communication and control principles of a single cell focusing on multiscale manipulatio

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Reed, William R., Carla R. Lima, Michael A. K. Liebschner, Christopher P. Hurt, Peng Li, and Maruti R. Gudavalli. "Measurement of Force and Intramuscular Pressure Changes Related to Thrust Spinal Manipulation in an In Vivo Animal Model." Biology 12, no. 1 (2022): 62. http://dx.doi.org/10.3390/biology12010062.

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Current knowledge regarding biomechanical in vivo deep tissue measures related to spinal manipulation remain somewhat limited. More in vivo animal studies are needed to better understand the effects viscoelastic tissue properties (i.e., dampening) have on applied spinal manipulation forces. This new knowledge may eventually help to determine whether positive clinical outcomes are associated with particular force thresholds reaching superficial and/or deep spinal tissues. A computer-controlled feedback motor and a modified Activator V device with a dynamic load cell attached were used to delive

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16

Cheah, C. C., X. Li, X. Yan, and D. Sun. "Simple PD Control Scheme for Robotic Manipulation of Biological Cell." IEEE Transactions on Automatic Control 60, no. 5 (2015): 1427–32. http://dx.doi.org/10.1109/tac.2014.2357132.

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17

Xie, Mingyang. "Autonomous robot-aided optical tweezer system for biological cell manipulation." International Journal of Advanced Manufacturing Technology 105, no. 12 (2019): 4953–66. http://dx.doi.org/10.1007/s00170-019-04683-1.

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18

Solano, Belen, Andrew J. Gallant, Gareth D. Greggains, David Wood, and Mary Herbert. "Low Voltage Microgripper for Single Cell Manipulation." Advances in Science and Technology 57 (September 2008): 67–72. http://dx.doi.org/10.4028/www.scientific.net/ast.57.67.

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In this work, we present the characterisation of an electrothermally actuated microgripper that operates in both dry and liquid media, and shows improved performance versus existing devices. The microgripper, fabricated in a combination of polymeric (SU8) and conductive materials (Au), is able to produce displacements up to 110 μm in air and 30 μm in liquid. In both cases, the voltage and the electrical power required is minimal (less than 3 V and 180 mW respectively) and so both, high temperatures and electrolysis, are prevented. Micromanipulation experiments have successfully demonstrated th

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19

Takahashi, Shunsuke, Masahiko Oshige, and Shinji Katsura. "DNA Manipulation and Single-Molecule Imaging." Molecules 26, no. 4 (2021): 1050. http://dx.doi.org/10.3390/molecules26041050.

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DNA replication, repair, and recombination in the cell play a significant role in the regulation of the inheritance, maintenance, and transfer of genetic information. To elucidate the biomolecular mechanism in the cell, some molecular models of DNA replication, repair, and recombination have been proposed. These biological studies have been conducted using bulk assays, such as gel electrophoresis. Because in bulk assays, several millions of biomolecules are subjected to analysis, the results of the biological analysis only reveal the average behavior of a large number of biomolecules. Therefor

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20

Juliano, Rudy L., Vidula R. Dixit, Hyunmin Kang, Tai Young Kim, Yuko Miyamoto, and Dong Xu. "Epigenetic manipulation of gene expression." Journal of Cell Biology 169, no. 6 (2005): 847–57. http://dx.doi.org/10.1083/jcb.200501053.

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Cell biologists have been afforded extraordinary new opportunities for experimentation by the emergence of powerful technologies that allow the selective manipulation of gene expression. Currently, RNA interference is very much in the limelight; however, significant progress has also been made with two other approaches. Thus, antisense oligonucleotide technology is undergoing a resurgence as a result of improvements in the chemistry of these molecules, whereas designed transcription factors offer a powerful and increasingly convenient strategy for either up- or down-regulation of targeted gene

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21

Santos, Rogério Lacerda dos, Matheus Melo Pithon, Fabiola Galbiatti Carvalho, Aretha Aliny dos Santos Ramos, and Maria Teresa Villela Romanos. "Mechanical and Biological Properties of Acrylic Resins Manipulated and Polished by Different Methods." Brazilian Dental Journal 24, no. 5 (2013): 492–97. http://dx.doi.org/10.1590/0103-6440201302293.

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This study evaluated the influence of the manipulation technique and polishing method on the flexural strength and cytotoxicity of acrylic resins. Two manipulation techniques and three polishing methods were used in the fabrication of acrylic plates that were divided into 6 groups (n=10). Groups MM, MC and MW: mass technique with mechanical polishing, chemical polishing and without polishing, respectively; and Groups SM, SC and SW: Saturation technique with mechanical polishing, chemical polishing and without polishing, respectively). Flexural strength was tested in a universal testing machine

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22

Vivek, Adithya, Guido Bolognesi, and Yuval Elani. "Fusing Artificial Cell Compartments and Lipid Domains Using Optical Traps: A Tool to Modulate Membrane Composition and Phase Behaviour." Micromachines 11, no. 4 (2020): 388. http://dx.doi.org/10.3390/mi11040388.

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New technologies for manipulating biomembranes have vast potential to aid the understanding of biological phenomena, and as tools to sculpt novel artificial cell architectures for synthetic biology. The manipulation and fusion of vesicles using optical traps is amongst the most promising due to the level of spatiotemporal control it affords. Herein, we conduct a suite of feasibility studies to show the potential of optical trapping technologies to (i) modulate the lipid composition of a vesicle by delivering new membrane material through fusion events and (ii) manipulate and controllably fuse

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23

NAITO, Mitsuru. "Development of avian embryo manipulation techniques and their application to germ cell manipulation." Animal Science Journal 74, no. 3 (2003): 157–68. http://dx.doi.org/10.1046/j.1344-3941.2003.00101.x.

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24

Kerr, Martin, Shireen A. Davies, and Julian A. T. Dow. "Cell-Specific Manipulation of Second Messengers." Current Biology 14, no. 16 (2004): 1468–74. http://dx.doi.org/10.1016/j.cub.2004.08.020.

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Akiyama, Y. "Design of Temperature-Responsive Cell Culture Surfaces for Cell Sheet Engineering." Cyborg and Bionic Systems 2021 (February 3, 2021): 1–15. http://dx.doi.org/10.34133/2021/5738457.

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Temperature-responsive cell culture surfaces, which modulate cell attachment/detachment characteristics with temperature, have been used to fabricate cell sheets. Extensive study on fabrication of cell sheet with the temperature-responsive cell culture surface, manipulation, and transplantation of the cell sheet has established the interdisciplinary field of cell sheet engineering, in which engineering, biological, and medical fields closely collaborate. Such collaboration has pioneered cell sheet engineering, making it a promising and attractive technology in tissue engineering and regenerati

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H. Korayem, M., Z. Rastegar, and M. Taheri. "Sensitivity Analysis of Nano-contact Mechanics Models in Manipulation of Biological Cell." Nanoscience and Nanotechnology 2, no. 3 (2012): 49–56. http://dx.doi.org/10.5923/j.nn.20120203.02.

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27

NAKAJIMA, Masahiro, Hirotaka HIDA, Yajing SHEN, Tsubasa KAKIO, Kazuo SATO, and Toshio FUKUDA. "2A2-S02 Biological Cell Analysis System using Comb-electrode Nanotool(Bio-Manipulation)." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2012 (2012): _2A2—S02_1—_2A2—S02_2. http://dx.doi.org/10.1299/jsmermd.2012._2a2-s02_1.

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28

Chu, Po-Yu, Chia-Hsun Hsieh, Chien-Ru Lin, and Min-Hsien Wu. "The Effect of Optically Induced Dielectrophoresis (ODEP)-Based Cell Manipulation in a Microfluidic System on the Properties of Biological Cells." Biosensors 10, no. 6 (2020): 65. http://dx.doi.org/10.3390/bios10060065.

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Cell manipulation using optically induced dielectrophoresis (ODEP) in microfluidic systems has attracted the interest of scientists due to its simplicity. Although this technique has been successfully demonstrated for various applications, one fundamental issue has to be addressed—Whether, the ODEP field affects the native properties of cells. To address this issue, we explored the effect of ODEP electrical conditions on cellular properties. Within the experimental conditions tested, the ODEP-based cell manipulation with the largest velocity occurred at 10 Vpp and 1 MHz, for the two cancer cel

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29

Zhang, Hu, and Kuo-Kang Liu. "Optical tweezers for single cells." Journal of The Royal Society Interface 5, no. 24 (2008): 671–90. http://dx.doi.org/10.1098/rsif.2008.0052.

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Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100 aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT

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Farasat, Malihe, Ehsan Aalaei, Saeed Kheirati Ronizi, et al. "Signal-Based Methods in Dielectrophoresis for Cell and Particle Separation." Biosensors 12, no. 7 (2022): 510. http://dx.doi.org/10.3390/bios12070510.

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Separation and detection of cells and particles in a suspension are essential for various applications, including biomedical investigations and clinical diagnostics. Microfluidics realizes the miniaturization of analytical devices by controlling the motion of a small volume of fluids in microchannels and microchambers. Accordingly, microfluidic devices have been widely used in particle/cell manipulation processes. Different microfluidic methods for particle separation include dielectrophoretic, magnetic, optical, acoustic, hydrodynamic, and chemical techniques. Dielectrophoresis (DEP) is a met

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Vodyakova, M. A., N. S. Pokrovsky, I. S. Semenova, V. A. Merkulov, and E. V. Melnikova. "Classification of Cell Therapy Products by Cell Manipulation Degree and Functions Performed: Analysis of International Regulatory Approaches." Regulatory Research and Medicine Evaluation 14, no. 5 (2024): 533–46. http://dx.doi.org/10.30895/1991-2919-2024-14-5-533-546.

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INTRODUCTION. The degree of processing (manipulation) of cells included in a cell product and the functions performed after administration (homologous/non-homologous use) determine the classification of the cell product as a transplant or an advanced therapy medicinal product (ATMP) and, hence, the regulatory aspects of the product’s life cycle. Currently, the legislation of the Eurasian Economic Union (EAEU) and the Russian Federation does not sufficiently explain the terms ‘minimal manipulation’ and ‘homologous/non-homologous use’, which may lead to the use of cell products with unproven saf

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Çağlayan, Zeynep, Yağmur Demircan Yalçın, and Haluk Külah. "A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis." Micromachines 11, no. 11 (2020): 990. http://dx.doi.org/10.3390/mi11110990.

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BioMEMS, the biological and biomedical applications of micro-electro-mechanical systems (MEMS), has attracted considerable attention in recent years and has found widespread applications in disease detection, advanced diagnosis, therapy, drug delivery, implantable devices, and tissue engineering. One of the most essential and leading goals of the BioMEMS and biosensor technologies is to develop point-of-care (POC) testing systems to perform rapid prognostic or diagnostic tests at a patient site with high accuracy. Manipulation of particles in the analyte of interest is a vital task for POC and

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Sitti, Metin, and Hideki Hashimoto. "Macro to Nano Tele-Manipulation Towards Nanoelectromechanical Systems." Journal of Robotics and Mechatronics 12, no. 3 (2000): 209–17. http://dx.doi.org/10.20965/jrm.2000.p0209.

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In this paper, manipulation systems from macro- to nanoworlds indispensable for constructing Nanoelectromechanical Systems (NEMS) are introduced, and a macro to Nanotelemanipulation System has been proposed. We selected the telerobotics manipulation for positioning micro/nanoobjects with sizes between 10nm and 10μm in 2D. A user interface enables operator to feel nanoforces using a haptic device, and see the 3D graphics of the nanoworld during manipulation. Force models, the manipulation strategy and teleoperation control are designed, and preliminary results are presented. Possible target app

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Park, Hyung-Joon, Hyunsik Hong, Ramar Thangam, et al. "Static and Dynamic Biomaterial Engineering for Cell Modulation." Nanomaterials 12, no. 8 (2022): 1377. http://dx.doi.org/10.3390/nano12081377.

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In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomateri

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35

Wilding, P., J. Pfahler, H. H. Bau, J. N. Zemel, and L. J. Kricka. "Manipulation and flow of biological fluids in straight channels micromachined in silicon." Clinical Chemistry 40, no. 1 (1994): 43–47. http://dx.doi.org/10.1093/clinchem/40.1.43.

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Abstract Analysis of minute sample volumes is a major analytical challenge that requires an understanding of fluid flow in microstructures. Accordingly, flow dynamics of biological fluids and cell suspensions in straight glass-capped silicon microchannels (40 to 150 microns wide, 20 and 40 microns deep) were studied. We demonstrated that these microstructures are appropriate components for microfluidic analytical devices. Different fluids were easily manipulated in the microchannels, and measurements of flow rate as a function of pressure for whole human blood, serum, plasma, and cell suspensi

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Vitorino, Rui, Sofia Guedes, João Pinto da Costa, and Václav Kašička. "Microfluidics for Peptidomics, Proteomics, and Cell Analysis." Nanomaterials 11, no. 5 (2021): 1118. http://dx.doi.org/10.3390/nano11051118.

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Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In p

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Uchida, M., M. Sato-Maeda, and H. Tashiro. "Micromanipulation: Whole-cell manipulation by optical trapping." Current Biology 5, no. 4 (1995): 380–82. http://dx.doi.org/10.1016/s0960-9822(95)00078-9.

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Tian, Zhenhua, Zeyu Wang, Peiran Zhang, et al. "Generating multifunctional acoustic tweezers in Petri dishes for contactless, precise manipulation of bioparticles." Science Advances 6, no. 37 (2020): eabb0494. http://dx.doi.org/10.1126/sciadv.abb0494.

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Acoustic tweezers are a promising technology for the biocompatible, precise manipulation of delicate bioparticles ranging from nanometer-sized exosomes to millimeter-sized zebrafish larva. However, their widespread usage is hindered by their low compatibility with the workflows in biological laboratories. Here, we present multifunctional acoustic tweezers that can manipulate bioparticles in a disposable Petri dish. Various functionalities including cell patterning, tissue engineering, concentrating particles, translating cells, stimulating cells, and cell lysis are demonstrated. Moreover, leak

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Bongaerts, Maud, Koceila Aizel, Emilie Secret, et al. "Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces." International Journal of Molecular Sciences 21, no. 18 (2020): 6560. http://dx.doi.org/10.3390/ijms21186560.

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The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles appears to be promising, since magnetic fields can act at a distance without interactions with the surrounding biological system. To control biological processes at a subcellular spatial resolution, magnetic nanoparticles can be used either to induce biochemical reactions locally or to apply forces on different elements of the cell. Here, we show that

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40

Cao, Yuhong, Enbo Ma, Stefano Cestellos-Blanco, et al. "Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules." Proceedings of the National Academy of Sciences 116, no. 16 (2019): 7899–904. http://dx.doi.org/10.1073/pnas.1818553116.

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We present a simple nanopore-electroporation (NanoEP) platform for delivery of nucleic acids, functional protein, and Cas9 single-guide RNA ribonucleoproteins into both adherent and suspension cells with up to 80% delivery efficiency and >95% cell viability. Low-voltage electric pulses permeabilize a small area of cell membrane as a cell comes into close contact with the nanopores. The biomolecule cargo is then electrophoretically drawn into the cells through the nanopores. In addition to high-performance delivery with low cell toxicity, the NanoEP system does not require specialized buffer

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Kojima, Nobuhiko, Ken Miura, Tomoki Matsuo, et al. "Rapid and Direct Cell-to-Cell Adherence Using Avidin-Biotin Binding System: Large Aggregate Formation in Suspension Culture and Small Tissue Element Formation Having a Precise Microstructure Using Optical Tweezers." Journal of Robotics and Mechatronics 22, no. 5 (2010): 619–22. http://dx.doi.org/10.20965/jrm.2010.p0619.

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Effectively organizing isolated cells to tissue elements having an appropriate microstructure is a fundamental issue in future tissue engineering, but biological cell-to-cell adhesion is too weak to assemble single cells directly. In order to overcome the difficulty, we applied an Avidin-Biotin Binding System (ABBS) to cell surfaces, and avidinylated and biotinylated cells could mutually bind in the short time they were mixed together. Unlike conventional intact cells, ABBS helped make larger spheroids. Interestingly, avidinylated and biotinylated cell adherence occurred within 1 sec using las

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Wang, Kunpeng, Zhelin Qu, Yifei Chen, et al. "Red Blood Cell-Based Biological Micromotors Propelled by Spiral Optical Fields." Photonics 12, no. 6 (2025): 531. https://doi.org/10.3390/photonics12060531.

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Micromotors play a crucial role in microsystems technology, with applications in nanoparticle propulsion, targeted drug delivery, and biosensing. Optical field propulsion, particularly optical tweezers (OTs), enables precise, noncontact control but traditionally relies on Gaussian traps, which require preprogramming and offer limited rotational control. Here, we introduce a micromotor driven by optical vortex beams, utilizing phase gradients to generate optical torque. This eliminates preprogramming and enables real-time control over rotation and positioning. Using this method, we design red b

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Lee, Moosung, Hervé Hugonnet, Mahn Jae Lee, Youngmoon Cho, and YongKeun Park. "Optical trapping with holographically structured light for single-cell studies." Biophysics Reviews 4, no. 1 (2023): 011302. http://dx.doi.org/10.1063/5.0111104.

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A groundbreaking work in 1970 by Arthur Ashkin paved the way for developing various optical trapping techniques. Optical tweezers have become an established method for the manipulation of biological objects, due to their noninvasiveness and precise controllability. Recent innovations are accelerating and now enable single-cell manipulation through holographic light structuring. In this review, we provide an overview of recent advances in optical tweezer techniques for studies at the individual cell level. Our review focuses on holographic optical tweezers that utilize active spatial light modu

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Jiang, Shengzhe, Dongping Wang, Kaidi Zhang, Baiquan Lin, Hanbin Ma, and Jun Yu. "41‐2: Invited Paper: Active‐matrix Digital Microfluidics System for High‐Throughput Droplet Sample Processing." SID Symposium Digest of Technical Papers 55, S1 (2024): 343–46. http://dx.doi.org/10.1002/sdtp.17078.

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We introduce a high‐throughput field programmable active‐matrix digital microfluidics system designed for large‐scale biological experiments. The fabricated microfluidics chip consists of a 640×280‐pixel array, each pixel measuring at 100×100 μm . This configuration enables the addressing of individual pixels, facilitating parallel droplet manipulation. The system utilizes 9T2C GOA circuits for generating row scanning signals, and 3T1C pixel circuits to provide driving voltage to individual pixels. The system exhibited a notably elevated proficiency in high‐resolution droplet generation and ma

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Haghizadeh, Anahita, Mariam Iftikhar, Shiba S. Dandpat, and Trey Simpson. "Looking at Biomolecular Interactions through the Lens of Correlated Fluorescence Microscopy and Optical Tweezers." International Journal of Molecular Sciences 24, no. 3 (2023): 2668. http://dx.doi.org/10.3390/ijms24032668.

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Understanding complex biological events at the molecular level paves the path to determine mechanistic processes across the timescale necessary for breakthrough discoveries. While various conventional biophysical methods provide some information for understanding biological systems, they often lack a complete picture of the molecular-level details of such dynamic processes. Studies at the single-molecule level have emerged to provide crucial missing links to understanding complex and dynamic pathways in biological systems, which are often superseded by bulk biophysical and biochemical studies.

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Li, Ying, Xiaoru Zhuang, and Fuzhou Niu. "Quantitative Investigation of the Link between Actin Cytoskeleton Dynamics and Cellular Behavior." Micromachines 13, no. 11 (2022): 1885. http://dx.doi.org/10.3390/mi13111885.

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Actin cytoskeleton reorganization, which is governed by actin-associated proteins, has a close relationship with the change of cell biological behavior. However, a perceived understanding of how actin mechanical property links to cell biological property remains unclear. This paper reports a label-free biomarker to indicate this interrelationship by using the actin cytoskeleton model and optical tweezers (OT) manipulation technology. Both biophysical and biochemical methods were employed, respectively, as stimuli for two case studies. By comparing the mechanical and biological experiment resul

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Ahmad Khalili, Amelia, Mohd Ahmad, Masaru Takeuchi, Masahiro Nakajima, Yasuhisa Hasegawa, and Razauden Mohamed Zulkifli. "A Microfluidic Device for Hydrodynamic Trapping and Manipulation Platform of a Single Biological Cell." Applied Sciences 6, no. 2 (2016): 40. http://dx.doi.org/10.3390/app6020040.

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He, Li, Jiuhong Huang, and Norbert Perrimon. "Development of an optimized synthetic Notch receptor as an in vivo cell–cell contact sensor." Proceedings of the National Academy of Sciences 114, no. 21 (2017): 5467–72. http://dx.doi.org/10.1073/pnas.1703205114.

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Detection and manipulation of direct cell–cell contact in complex tissues is a fundamental and challenging problem in many biological studies. Here, we report an optimized Notch-based synthetic receptor (synNQ) useful to study direct cell–cell interactions in Drosophila. With the synNQ system, cells expressing a synthetic receptor, which contains Notch activation machinery and a downstream transcriptional activator, QF, are activated by a synthetic GFP ligand expressed by contacting neighbor cells. To avoid cis-inhibition, mutually exclusive expression of the synthetic ligand and receptor is a

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Chuang, Sih-Chi, Shih-An Yu, Pei-Chia Hung, Hsien-Tsung Lu, Hieu-Trung Nguyen, and Er-Yuan Chuang. "Biological Photonic Devices Designed for the Purpose of Bio-Imaging with Bio-Diagnosis." Photonics 10, no. 10 (2023): 1124. http://dx.doi.org/10.3390/photonics10101124.

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The rapid progress in the fields of biomedical and biological photonic sciences has given rise to a substantial demand for biological photonic structures capable of interacting with living systems. These structures are expected to facilitate precise manipulation of incident light at small scales, enabling the detection of sensitive biological signals and the achievement of highly accurate cell structural imaging. The concept of designing biological photonic devices using innate biomaterials, particularly natural entities such as cells, viruses, and organs, has gained prominence. These innovati

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Immerstrand, C., K. Holmgren-Peterson, K. E. Magnusson, et al. "Conjugated-Polymer Micro- and Milliactuators for Biological Applications." MRS Bulletin 27, no. 6 (2002): 461–64. http://dx.doi.org/10.1557/mrs2002.146.

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AbstractThe development of new conjugated-polymer tools for the study of the biological realm, and for use in a clinical setting, is reviewed in this article. Conjugated-polymer actuators, based on the changes of volume of the active conjugated polymer during redox transformation, can be used in electrolytes employed in cell-culture media and in biological fluids such as blood, plasma, and urine. Actuators ranging in size from 10 μm to 100 μm suitable for building structures to manipulate single cells are produced with photolithographic techniques. Larger actuators may be used for the manipula

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