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Relevant bibliographies by topics / Biological cells characterization / Dissertations / Theses

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Dissertations / Theses on the topic 'Biological cells characterization'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Pillarisetti, Anand. "Mechanical manipulation and characterization of biological cells." College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8779.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Yao, Xiaosai. "Functional characterization of mobilized tumor cells." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90679.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 101-106).<br>Despite being responsible for 90% of cancer mortality, metastasis is not well understood. This thesis is focused on the circulation step of the metastatic cascade, examining three types of mobilized tumor cells: circulating tumor cells (CTCs), intraoperatively shed tumor cells, and malignant pleural effusions (MPE). We investigated the functional behavior of mobilized tumor cells in order to explai

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3

Goods, Brittany A. (Brittany Anne Thomas). "Molecular characterization of T cells across disease states in the central nervous system." Thesis, Massachusetts Institute of Technology, 2017. https://hdl.handle.net/1721.1/122830.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017<br>Cataloged from PDF version of thesis. "February 2017."<br>Includes bibliographical references (pages 157-170).<br>The local cytokine milieu shapes the nature and function of immune cells and by extension the overall course of tissue-specific immune responses. In the context of cancer and autoimmunity, two opposing immune responses, the local immune environment can lead to dysfunctional T cell states. Understanding the mechanisms that distinguish these two states is key to identifying unique pat

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4

Söderdahl, Therese. "Characterization of biotransformation systems in human cells : focus on stem cells and their progeny /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-206-4/.

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5

Beickelman, Amy C. "The synthesis and biological characterization of a potential hypoxic cell sensitizer /." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1197412856.

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Thesis (M.S.)--University of Toledo, 2007.<br>Typescript. "Submitted as partial fulfillment of the requirements for The Master of Pharmaceutical Sciences." "A thesis entitled"--at head of title. Bibliography: leaves 53-55.

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6

Mudumba, Sreenivasu. "Characterization of polyamine-induced differentiation in PC12 cells." Scholarly Commons, 1997. https://scholarlycommons.pacific.edu/uop_etds/2609.

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The present investigation focused on three different aspects of polyamine involvement in induction of cell differentiation and neurite outgrowths: effects of polyamines on isolated bovine brain tubulin assembly, effects of polyamines on dopamine levels in PC12 cells, and influence of differentiating agents on polyamine and acetylpolyamine levels in PC12 cells. Among the polyamines, only spermine significantly induced tubulin assembly starting at 60 $\mu$M concentration (p $<$ 0.05). Colchicine at 100 $\mu$M concentration, and calcium chloride at 5 mM concentration inhibited spermine-induced po

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7

Gyger, Markus. "Active and Passive Biomechanical Measurements for Characterization and Stimulation of Biological Cells." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-124199.

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From a physical perspective biological cells consist of active soft matter that exist in a thermodynamic state far from equilibrium. Not only in muscles but also during cell proliferation, wound healing, embryonic development, and many other physiological tasks, generation of forces on the scale of whole cells is required. To date, cellular contractions have been ascribed to adhesion dependent processes such as myosin driven stress fiber formation and the development of focal adhesion complexes. In this thesis it is shown for the first time that contractions can occur independently of focal ad

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8

Yang, Yanyin. "Synthesis, characterization, microfabrication and biological applications of conducting polymers." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127316668.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 192 p.; also includes graphics (some col.). Includes bibliographical references (p. 183-192). Available online via OhioLINK's ETD Center

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9

Hashimura, Yasunori 1980. "Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28529.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Includes bibliographical references (leaves 81-83).<br>Although embryonic stem (ES) cells and their pluripotent capability have been elucidated for decades, little study has been done on obtaining the pluripotency profile of ES cells in the incipient stages of differentiation. In this research, an ES cell line with transfected green fluorescent protein (GFP) co-expressed by an Oct-4 promoter was analyzed by fluorescence-activated cell sorter (FACS) to obtain such profile. As Oct-4 is an ES cell d

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Wack, Kathryn E. (Kathryn Eilleen) 1978. "Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/18041.

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Thesis (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Includes bibliographical references (leaves 59-61).<br>One of the major challenges in liver research today lay in the understanding of the complex relationship between liver structure and function. The highly orchestrated events that take place in the liver to maintain homeostasis require the presence of all liver cell types. In vivo experiments offer only a snapshot of the liver, and usually involve perturbation of normal function through injury or experimental disease. The role of cell-cell intera

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11

Antecol, Michael Hal. "Biochemical and biological characterization of normal skin fibroblasts from individuals predisposed to dominantly inherited cancers." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74010.

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12

Laterza, Claudio <1980&gt. "Circulating Endothelial Progenitor Cells: isolation and biological characterization of EPCs from healthy subjects and nephropatic patients." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4745/.

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Nel 1997 venne isolata una popolazione cellulare con caratteristiche appartenenti a cellule endoteliali mature e a cellule progenitrici ; le cellule appartenenti a queste popolazione furono denominate EPCs (cellule endoteliali progenitrici circolanti) e fu messa in evidenza la loro capacità di dare origine a vasculogenesi postnatale. Lo scopo dello studio è stata la caratterizzazione di tale popolazione cellulare in termini biologici e la valutazione delle differenze delle EPCs in soggetti sani e nefropatici in emodialisi. È stata infine valutata l’eventuale capacità della Vitamina D di in

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13

Amirouche, Amin. "Integration of functions dedicated to the mechanical solicitation and characterization of biological cells in microfluidic devices." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1226/document.

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Cette thèse vise à évaluer deux techniques différentes pour la distinction d'échantillons biologiques mécaniquement altérés. Les deux approches ont été mises au point et étudiées avec un objectif à long terme qui est l'application de ces méthodes au diagnostic basé sur le phénotype mécanique. Bien que, nous avons élaboré ces approches dans le cas de globules rouges (GR), comme leurs propriétés mécaniques peuvent être affectées par des pathologies importantes, tous les concepts développés dans ce travail peuvent être adaptés à d'autres types de cellules.Nous avons caractérisé les propriétés méc

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14

Shrestha, Ramesh. "Micro-Pipette Thermal Sensor: A Unique Technique for Thermal Characterization of Microfluids, Microspheres, and Biological Cells." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703406/.

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In this research work, an innovative method for measurement of thermal conductivity of a small volume of liquids, microsphere, and the single cancer cell is demonstrated using a micro-pipette thermal sensor (MPTS). The method is based on laser point heating thermometry (LPHT) and transient heat transfer. When a single pulse of a laser beam heats the sensor tip which is in contact with the surrounding liquids or microsphere/cells, the temperature change in the sensor is reliant on the thermal properties of the surrounding sample. We developed a model for numerical analysis of the temperature ch

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Moutinho, Cátia. "Characterization of the DNA methylation patterns of chemosensitive and chemoresistant human cancer cells: Biological and clinical impact." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/286599.

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Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful patient’s treatment. Understanding the cellular mechanisms leading to chemoresistance may dramatically impact on the way chemotherapeutic drugs are used. Then, it would allow selecting the most suitable personalized therapy. It has become increasingly clear that many chemotherapeutic agents kill susceptible cells through the induction of the physiological cell death program. Accordingly, deregula

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Gadepalli, Venkat Sundar. "ISOLATION AND CHARACTERIZATION OF MULTIPOTENT LUNG STEM CELLS FROM p53 MUTANT MICE MODELS." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3644.

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Recent advances in understanding lung biology have shown evidence for the existence of resident lung stem cells. Independent studies in identifying and characterizing these somatic lung stem cells have shown the potential role of these cells in lung repair and regeneration. Understanding the functional characteristics of these tissue resident stem/progenitor cells has gained much importance with increasing evidence of cancer stem cells, cells in a tumor tissue with stem cell characteristics. Lung cancer is most commonly characterized by loss of p53 function which results in uncontrolled cell d

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17

Gosselin, Edmund J. "Characterization of Antigen-Specific Antigen Processing by the Resting B cell: a Thesis." eScholarship@UMMS, 1988. https://escholarship.umassmed.edu/gsbs_diss/199.

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An optimal antibody response to a thymus-dependent antigen requires cooperation between the B cell and an antigen-specific helper T cell. Major histocompatibility complex restriction of this interaction implies that the helper T cell recognizes antigen on the B cell surface in the context of MHC molecules, and that the antigen-specific B cell gets help by acting as an antigen presenting cell for the helper T cell. However, a number of studies have shown that normal resting B cells are ineffective as antigen presenting cells, implying that the B cell must leave the resting state before it can i

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Strahonja, Andreja. "Characterization, Mechanisms and Modulation of Calcium Signals in Glia: a Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/215.

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Glia are non-excitable cells found in nervous tissue, and have an important role in synaptic plasticity and the maintenance of neuronal environment, as well as the activity, development, degeneration, and repair of neurons. Glial cells are interconnected via gap junctions to form a multicellular syncytium and utilize intercellular and intracellular Ca2+signals to regulate their functions. Glial Ca2+ signals regulate important cell functions that include gene expression, cell proliferation, metabolism, ion transport systems, release of cell products, and cell death. Consequently, significant al

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19

Pelletier, Diane Beatrice. "Identification and partial biological characterization of autocrine growth inhibitory activity in Nb2 lymphoma cell conditioned medium." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185002.

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The purpose of these studies was to determine whether lactogen-dependent Nb2-11c cells and lactogen-independent Nb2-SP cells differ with respect to morphology and autocrine growth control. To this end, the ultrastructural and surface morphology of both Nb2 cell lines was analyzed and the autocrine growth modulatory activity of Nb2 cell conditioned medium (Nb2-CM) was determined. The autocrine growth inhibitory activity of Nb2-CM was biologically characterized and attempts were made to biochemically characterize and purify the Nb2 cell autocrine growth inhibitor as well as to determine its mech

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Yang, Chiming. "Parathyroid hormone effects on marrow stromal cells for potantial bone regeneration applications : delivery systems development and biological characterization." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/15882.

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Despite the inherent ability of bone tissue to regenerate upon damage, there are incidences such as ‘critical’ defects where the damaged and lost bone will not repair or regenerate itself. Thus, the natural bone regeneration process must be augmented with the application of therapeutic agents (growth factors, hormones, cells). In addition, in every possible scenario where surgical interventions are performed, there exists the risk of infections that must be minimized and managed with the administration of antibiotics. The overall goals of this thesis were to engineer, develop, and characterize

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Yang, Chiming. "Parathyroid hormone effects on marrow stromal cells for potential bone regeneration applications : delivery systems development and biological characterization." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/15882.

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Despite the inherent ability of bone tissue to regenerate upon damage, there are incidences such as ‘critical’ defects where the damaged and lost bone will not repair or regenerate itself. Thus, the natural bone regeneration process must be augmented with the application of therapeutic agents (growth factors, hormones, cells). In addition, in every possible scenario where surgical interventions are performed, there exists the risk of infections that must be minimized and managed with the administration of antibiotics. The overall goals of this thesis were to engineer, develop, and characteriz

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22

Castro, Smirnov Fidel Antonio. "Physicochemical characterization of DNA-based bionanocomposites using nonafibrous clay minerals : biological applications." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112260/document.

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Parmi les différents minéraux argileux, la sépiolite, qui est un silicate fibreux naturel, est un potentiel nano-transporteur prometteur pour le transfert non-viral de biomolécules. Il a en effet été montré que la sépiolite interagissait avec des molécules biologiques telles que les lipides, les polysaccharides et les protéines. Dans ce travail, nous démontrons que la sépiolite interagit également efficacement avec différents types de molécules d'ADN (génomique, plasmidique, oligonucléotides simple et double brin), et nous présentons la première étude détaillée sur les mécanismes d'interaction

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23

Padgaonkar, Amol. "Discovery, Biological and Structural Characterization of ON108600, a Novel Kinase Inhibitor in Triple Negative Breast Cancer." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/269327.

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Molecular Biology and Genetics<br>Ph.D.<br>Selective killing of tumor cells requires the identification of drug targets critical to pathways that drive or support cancer progression. Protein kinases are an important class of intracellular enzymes involved in the regulation of biochemical pathways, deregulation of these kinases has been strongly implicated in cancer progression. To identify possible oncogenic kinases to which tumor cells might be selectively addicted, we screened the ON108 series of ATP-mimetic small molecule inhibitors in various triple negative breast cancer (TNBC) and normal

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Lucchesi, Pamela A. "Plasma Membrane Processes in Smooth Muscle: Characterization of Ca²⁺ Transport and Muscarinic Cholinergic Receptors: A Thesis." eScholarship@UMMS, 1989. https://escholarship.umassmed.edu/gsbs_diss/135.

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The thesis research was designed to study the characteristics of two important physiological processes in smooth muscle: Ca2+ transport mediated by the plasmalemmal Ca2+-ATPase and muscarinic receptor-G protein interactions. In resting smooth muscle, several Ca2+ extrusion or sequestration processes offset the passive inward leak of Ca2+. Although biochemical evidence suggests that the plasmalemmal Ca2+ pump plays a key role in this process, the precise role of this enzyme could not be proven until a reliable estimate of the inward Ca2+ leak was measured. Recent studies using dispersed smooth

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McDonald, Lucas J. "Synthesis and Characterization of Novel Flavonoid-Based Fluorescent Sensors and other Sensors with Excited State Intramolecular Proton Transfer for Biological Applications." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524658238472646.

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Väisänen, M. R. (Marja-Riitta). "Type XIII collagen:characterization of ectodomain shedding and its biological implications in mammalian cells, characterization of type XIII collagen expression in human cancers." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514279085.

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Abstract Type XIII collagen is an integral membrane protein in type II orientation. In cells and tissues type XIII collagen has been located in various adhesive structures, like focal adhesions. Due to this, its biological role has been implicated in cell adhesion. This collagen also exists as a soluble protein due to the release of the ectodomain from the plasma membrane. In this thesis, ectodomain shedding, i.e. enzymatic release of the extracellular domain, was studied in detail, focusing on the phenomenon as it occurs in mammalian cells. It was found that the ectodomain is released by me

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Le-Niculescu, Helen. "Characterization of the biological roles of the JNK MAPK pathways in mammalian cells : specific and stringent activation of the JNKK2-JNK signaling module /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9984810.

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Gyger, Markus [Verfasser], Josef A. [Akademischer Betreuer] Käs, Josef A. [Gutachter] Käs, and Manfred [Gutachter] Radmacher. "Active and Passive Biomechanical Measurements for Characterization and Stimulation of Biological Cells / Markus Gyger ; Gutachter: Josef A. Käs, Manfred Radmacher ; Betreuer: Josef A. Käs." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238526705/34.

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Xu, Minzhen. "Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation". eScholarship@UMMS, 1991. https://escholarship.umassmed.edu/gsbs_diss/99.

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The antibody class switch is achieved by DNA recombination between the sequences called switch (S) regions located 5' to immunoglobulin (Ig) heavy chain constant (CH) region genes. This process can be induced in cultured B cells by polyclonal stimulation and switching can be directed to specific antibody classes by certain lymphokines. These stimuli may regulate the accessibility of CH genes and their S regions to a recombinase as indicated by hypomethylation and transcriptional activity. For example, RNAs transcribed from specific unrearranged (germ-line) CH genes are induced prior to switchi

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Yin, Zhao. "Characterization of the biological function of AtEXO70E2." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/483.

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Exocyst positive organelle (EXPO) is a newly discovered double membrane organelle involved in exocytosis and likely other vesicle trafficking processes. EXPO is likely generated from the ER, fused with plasma membrane and released a single membrane vesicle to cell exterior. The Arabidopsis protein Exo70E2 was found to be associated with EXPO and therefore is considered as a marker of EXPO and might play a role in EXPO-mediated vesicle trafficking. Understanding the biological function of AtExo70E2 (abbreviated as E2 in this thesis) will be very helpful in unraveling the function of EXPO. The a

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Levinson, Joshua N. "Functional and cell biological characterization of Saccharomyces cerevisiae Kre5p." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33798.

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Saccharomyces cerevisiae Kre5p is important for the biosynthesis of beta-1,6-glucan, which is required for proper cell wall assembly and architecture. A functional and cell biological analysis of Kre5p was conducted to further elucidate its role in beta-1,6-glucan synthesis. Kre5p was found to be a primarily soluble N-glycoprotein of &sim;200 kD that localizes to the endoplasmic reticulum. Observation of Kre5p-deficient cells reveals a severe cell wall morphological defect, and kre5Delta cells were shown to have only residual levels of beta-1,6-glucan. KRE6 was identified as a multicopy suppre

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32

Hjeij, Fatima. "Caractérisation diélectrique de cellules biologiques par diélectrophorèse haute fréquence." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0039/document.

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Les travaux présentés dans ce manuscrit de thèse concernent le développement d’une méthode de caractérisation électrique de cellules biologiques, sans marquage, basée sur la diélectrophorèse Ultra Haute Fréquence (DEP-UHF). Sous l’action d’un champ électrique alternatif non uniforme, les cellules biologiques sont soumises à des forces de déplacement essentiellement liées à leurs propriétés diélectriques. En particulier, aux hautes fréquences, le champ électrique pénètre à l’intérieur de la cellule et interagit donc avec son contenu intracellulaire. Il est donc possible d’accéder à une «signat

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33

Beickelman, Amy C. "The Synthesis and Biological Characterization of a Potential Hypoxic Cell Sensitizer." University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1197412856.

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34

Bos, Cindy Renee. "Characterization of membrane traffic from the cell surface to the Golgi complex." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1059144443.

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Morrill, Joyce Catherine. "Characterization of the down regulation of antibody production in high cell density perfusion culture." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/32602.

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O'Neill, Ryan C. "Biochemical and cell biological characterization of 2', 3'-cyclic nucleotide 3'-phosphodiesterase isoform 2." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38253.

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2',3'-cyclic nucleotide 3 '-phosphodiesterase is one of the earliest expressed myelin-associated genes. Highest levels of this protein are produced in oligodendrocytes, the myelinating cells of the central nervous system. Schwann cells, the myelinating cells of the peripheral nervous system possess lower levels, followed by non-neural cells, such as lymphocytes, retinal cells and thymocytes. There are two isoforms of CNP: CNP1 (46kDa) and CNP2 (48kDa). CNP2 differs from CNP1 only by a 20 amino acid N-terminal extension. In addition, CNP2 is more heavily phosphorylated than CNP1. Although a mes

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Nealey, Luke T. "The isolation, characterization, and biological testing of xyloglucan from suspension cultured lobloly pine cell spent medium." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/5749.

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Najberg, Mathie. "Development, physico-chemical characterization and biological evaluation of silk fibroin/hyaluronic acid freeze-dried sponges for the trapping of Glioblastoma cells Reversing the tumor target: Establishment of a tumor trap Development of a non-toxic and non-denaturing formulation process for encapsulation of SDF-1α into PLGA/PEG-PLGA nanoparticles to achieve sustained release". Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0040.

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Le glioblastome (GBM) est une tumeur dévastatrice du système nerveux central. Malgré un traitement agressif, les récidives sont inévitables et l'application d'une stratégie thérapeutique efficace demeure un défi. Le concept révolutionnaire de piège à cellules cancéreuses peut offrir de nouvelles opportunités. L'objectif est d'attirer et de confiner les cellules cancéreuses résiduelles entourant la cavité chirurgicale dans un implant polymère biomimétique délivrant des molécules chimio attractantes. Le SDF-1α, également appelé CXCL12, se lie sélectivement au récepteur CXCR4 à la surface des cel

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Barth, Mareike [Verfasser], and Werner W. [Akademischer Betreuer] Franke. "The cell and molecular biological characterization of cell-cell junctions in mammalian heart valves / Mareike Barth ; Betreuer: Werner W. Franke." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/117922874X/34.

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Younis, Shady. "Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329190.

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The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. A mutation in the binding site of ZBED6, located in an intron of IGF2, disrupts the binding and leads to 3-f

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Chu, Wei. "Mouse Mast Cell Proteases: Induction, Molecular Cloning, and Characterization." Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2656.

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Tryptase, a mast cell-specific serine protease with trypsin-like specificity, has been identified in a mouse mast cell line (ABFTL-6) based on it's enzymatic activity, inhibition properties, and cross-reactivity to a human mast cell tryptase antibody. The effects of fibroblast-conditioned medium and sodium butyrate on ABFTL-6 mast cell differentiation and tryptase expression have been examined. ABFTL-6 mouse mast cells undergo phenotypic changes upon culturing in media supplemented with fibroblast-conditioned media at 50% or 1 mM sodium butyrate. The induced cells increased in

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Volk, Anna-Luisa. "Cell line and protein engineering tools for production and characterization of biologics." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-212931.

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Our increasing understanding of disease mechanisms coupled with technological advances has facilitated the generation of pharmaceutical proteins, which are able to address yet unmet medical needs. Diseases that were fatal in the past can now be treated with novel biological medications improving and prolonging life for many patients. Pharmaceutical protein production is, however, a complex undertaking, which is by no means problem-free. The demand for more complex proteins and the realization of the importance of post-translational modifications have led to an increasing use of mammalian cells

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Di, Silvio Desire. "Physical-chemical characterization of nanoparticles in relevant biological environments and their interactions with the cell surface." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/58403/.

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Nanoparticles (NPs) are versatile tools for nanomedicine and tuning features such as material, size and charge, imaging and targeting can be accomplished. However, NPs behaviour in vivo is modified upon interaction with the biological matter and formation of a protein corona (PC) coating the NP. The PC determines the NP biological identity and it is the ultimate interface with the surrounding environment. Therefore, a deep characterization of the NPs in biological media is important to predict adverse effects and improve NPs design. The aim of this thesis was to understand the effect of the PC

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Segerer, Gabriela [Verfasser], and Antje [Gutachter] Gohla. "Characterization of cell biological and physiological functions of the phosphoglycolate phosphatase AUM / Gabriela Segerer ; Gutachter: Antje Gohla." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1174929111/34.

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Valenciano, Murillo Ana Lisa. "Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/79769.

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Trypanosoma brucei species are vector-borne protozoan parasites that cause Human African typanosomiasis (HAT) and nagana in cattle. In humans, the diseases caused by these parasites are fatal if left untreated. Treatments for these diseases are complicated because the approved drugs for treatment are ineffective against the parasites and have many toxic side effects associated with their use. There is a clear need to identify new therapeutics that are less toxic and more effective against T. brucei. Our approach for identifying new therapies is to identify novel targets in the parasite that ca

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Martínez, Barriocanal Agueda. "Molecular and functional characterization of irem-3, a new activating member of the cmrf/irem family." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7159.

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En los últimos años hemos sido testigos de la identificación de múltiples familias de receptores inmunológicos. En este contexto encontramos la recientemente descrita familia IREM/CD300 localizada en la región cromosómica 17q25.1 y restringida en expresión a las células de origen mieloide. El locus humano se compone de dos genes codificantes para receptores con propiedades inhibidoras (IRp60/CD300a y IREM-1/CD300f), dos genes codificantes para receptores con naturaleza activadora (IREM-2/CD300e y IREM-3/CD300b) y dos genes codificantes para receptores con características que no permiten su inc

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Blanco, Carcache Peter Josephin. "Chemical Characterization and Biological Evaluation of Secondary Metabolites Isolated from Glycosmis ovoidea." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1580383951030389.

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Manrique, Blanco Thibaldo Javier. "The partial purification and characterization of a soluble activator for the sodium adenosinetriphosphatase from rat cerebral cortex and the effect of cholinergic agents." Scholarly Commons, 1986. https://scholarlycommons.pacific.edu/uop_etds/2117.

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Burnette-Vick, Bonnie A. "Characterization of Two Temperature-sensitive Mutants of Escherichia Coli Exhibiting an Altered L22 Ribosomal Protein." Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2645.

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Analysis of E. coli strains SK1047 and SK1048 have shown them to be temperature-sensitive, protein-synthesis deficient. An alteration in ribosomal protein L22 was detected in both strains using two dimensional gel electrophoresis. Protein L22 was purified from both strains by reversed phase high performance liquid chromatography and from two dimensional electrophoretic gels. Purified ribosomal protein L22 was labeled by reductive methylation and used in 23S RNA binding assays with and without ribosomal protein L4. At the permissive temperature, protein L22 from SK1047 bound less efficiently th

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Baiti, Risa Nurin. "Characterization of nano-mechanical properties of biological lipid membranes with circular mode atomic force microscopy." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2403/document.

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Les membranes cellulaires sont impliquées dans de nombreux processus cellulaires : la diffusion des médicaments et des ions, la transduction des signaux, la génération d'énergie, le développement cellulaire (fusion et fission). Les bicouches phospholipides sont les principaux composants des membranes cellulaires, elles constituent une barrière dynamique protégeant les réactions biochimiques cellulaires. La détermination des propriétés biochimiques et mécaniques des bicouches lipidiques et leur évolution avec les conditions environnementales est nécessaire pour étudier la nature des processus c

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