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Dissertations / Theses on the topic 'Biological Crises'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Guillam, Elvis. "Les deux crises biologiques de la fin du Dévonien : les ostracodes marqueurs des variations paléoenvironnementales et des relations paléobiogéographiques." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS157.pdf.

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Au cours des temps géologiques, la vie s'est grandement complexifiée et a connu de nombreuses et importantes variations de biodiversité. Parmi les déclins du Phanérozoïque (-541.0 ± 1.0 Ma à actuel), cinq grandes crises sont considérées comme majeures. L'une d'elles, appelée événement Kellwasser, marque la limite entre le Frasnien et le Famennien (-372 ± 1.6 Ma). Elle est suivie à la transition Dévonien-Carbonifère par un second événement de premier ordre, appelé événement Hangenberg. Ces événements de nature anoxique auraient été déclenchés par les importants changements climatiques caractéri

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2

Lynteris, Christos. "Epidemic events : state-formation, class struggle and biopolitics in three epidemic crises of modern China." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/2150.

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Based on extended research on Chinese medical and epidemiological archival material dating back to the beginning of the 20th century, and on six months of internship in epidemiology in Beijing’s Medical School and in Haidian District’s Centre of Disease Control and Prevention, this thesis explores the conjunction of three major epidemiological crises in modern Chinese history with processes of State formation: the 1911 Manchurian pneumonic plague, the 1952 germ-warfare, and the 2003 SARS outbreak. Analysing the three crises as Events in line with Alain Badiou’s epistemology it seeks to establi

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3

Siebel, Anna Maria. "O papel do sistema purin?rgico e da via de sinaliza??o TOR em crises convulsivas e estresse oxidativo." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2013. http://tede2.pucrs.br/tede2/handle/tede/5474.

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Made available in DSpace on 2015-04-14T14:51:28Z (GMT). No. of bitstreams: 1 451454.pdf: 6697842 bytes, checksum: 890c954db41088b36538c3133a7c2606 (MD5) Previous issue date: 2013-09-27<br>Epilepsy, characterized by the occurrence of spontaneous and recurrent seizures, is one of the main chronic neurological diseases, affecting around 1% of the world's population. Adenosine is an endogenous modulator of neuronal excitability and has anticonvulsant properties. Thus, the modulation of adenosinergic signalling pathway may presents important effects on epilepsy. In this study we characterize diff

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4

Siebel, Anna Maria. "Efeito de crises convulsivas e f?rmacos antiepil?pticos em par?metros neuroqu?micos e moleculares em peixe zebra (Danio rerio)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/5392.

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Made available in DSpace on 2015-04-14T14:51:06Z (GMT). No. of bitstreams: 1 431137.pdf: 15580738 bytes, checksum: 8de463b0a32f5623e6e47a0d1d0edad2 (MD5) Previous issue date: 2011-03-10<br>A epilepsia ? uma desordem neuronal caracterizada pela ocorr?ncia de convuls?es espont?neas e recorrentes. Essa patologia e seu tratamento interferem em diversos mecanismos neurol?gicos. O sistema purin?rgico ? uma importante rota de sinaliza??o celular que emprega nucleot?deos e nucleos?deos extracelulares como mol?culas sinalizadoras. O neurotransmissor ATP atua atrav?s de receptores do tipo P2Y, acoplad

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Schwengber, Solange Pereira. "Utiliza??o de marcadores de cromossomo Y como ferramenta visando a elucida??o de casos de crimes sexuais na gen?tica forense." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2008. http://tede2.pucrs.br/tede2/handle/tede/5324.

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Made available in DSpace on 2015-04-14T14:50:52Z (GMT). No. of bitstreams: 1 405027.pdf: 58857 bytes, checksum: 3137651cc6ea0e3ba8d2644d92086797 (MD5) Previous issue date: 2008-08-28<br>Marcadores moleculares de cromossomo Y s?o essenciais ? per?cia em gen?tica forense. Os marcadores moleculares STR (Short Tandem Repeats) espec?ficos para o cromossomo Y s?o amplamente utilizados nos Laborat?rios de Per?cias. Entretanto, n?o havia dados estat?sticos pr?prios do Estado do Rio Grande do Sul, implicando na utiliza??o de bancos de dados alternativos (brasileiro e europeu). Assim, a forma??o de um

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Lopes, Rodrigo Pestana. "Efeitos neuroimunoend?crinos do estresse por abuso f?sico ou neglig?ncia na inf?ncia em mulheres com depress?o maior." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/5405.

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Made available in DSpace on 2015-04-14T14:51:10Z (GMT). No. of bitstreams: 1 431890.pdf: 1738256 bytes, checksum: 1de40e064eb7209fe3bee4e61b0b071b (MD5) Previous issue date: 2011-03-28<br>INTRODU??O: Sabe-se que experi?ncias traum?ticas na inf?ncia podem levar ao surgimento de dist?rbios psiqui?tricos na vida adulta, incluindo a depress?o maior (DM). Contudo, ainda se desconhece o grau de altera??es biol?gicas que eventos estressores traum?ticos vivenciados na inf?ncia podem produzir em indiv?duos com depress?o. OBJETIVOS: Investigar par?metros neuroend?crinos e imunol?gicos em mulheres adul

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7

Gusso, Darlan. "Efeito do Piriproxifeno sobre o desenvolvimento, par?metros comportamentais e end?crinos em larvas e adultos de Peixe-zebra (Danio rerio)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/7950.

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Submitted by PPG Biologia Celular e Molecular (bcm@pucrs.br) on 2018-04-04T12:33:24Z No. of bitstreams: 1 DARLAN_GUSSO_DIS.pdf: 1507228 bytes, checksum: e2389f511956dbb64bb7b767d8f73e40 (MD5)<br>Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-04-19T16:26:33Z (GMT) No. of bitstreams: 1 DARLAN_GUSSO_DIS.pdf: 1507228 bytes, checksum: e2389f511956dbb64bb7b767d8f73e40 (MD5)<br>Made available in DSpace on 2018-04-19T16:43:13Z (GMT). No. of bitstreams: 1 DARLAN_GUSSO_DIS.pdf: 1507228 bytes, checksum: e2389f511956dbb64bb7b767d8f73e40 (MD5) Previous issue d

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Menezes, Fabiano Peres. "Interfer?ncias na sinaliza??o adenosin?rgica durante a embriog?nese acarretam em altera??es duradouras na morfologia e na sensibilidade a pr?-convulsivantes em peixe-zebra (Danio rerio)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/8117.

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Submitted by PPG Biologia Celular e Molecular (bcm@pucrs.br) on 2018-05-24T14:27:28Z No. of bitstreams: 1 FABIANO_PERES_MENEZES_TES.pdf: 24793474 bytes, checksum: 8b7fdf3efa2bb4839dd339d485cee522 (MD5)<br>Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-06-11T14:26:49Z (GMT) No. of bitstreams: 1 FABIANO_PERES_MENEZES_TES.pdf: 24793474 bytes, checksum: 8b7fdf3efa2bb4839dd339d485cee522 (MD5)<br>Made available in DSpace on 2018-06-11T14:31:14Z (GMT). No. of bitstreams: 1 FABIANO_PERES_MENEZES_TES.pdf: 24793474 bytes, checksum: 8b7fdf3efa2bb4839dd339d485ce

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Siebel, Anna Maria. "O papel do sistema purinérgico e da via de sinalização TOR em crises convulsivas e estresse oxidativo." Pontifícia Universidade Católica do Rio Grande do Sul, 2013. http://hdl.handle.net/10923/5484.

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Made available in DSpace on 2013-10-11T13:35:16Z (GMT). No. of bitstreams: 1 000451454-Texto+Completo-0.pdf: 6697842 bytes, checksum: 890c954db41088b36538c3133a7c2606 (MD5) Previous issue date: 2013<br>Epilepsy, characterized by the occurrence of spontaneous and recurrent seizures, is one of the main chronic neurological diseases, affecting around 1% of the world's population. Adenosine is an endogenous modulator of neuronal excitability and has anticonvulsant properties. Thus, the modulation of adenosinergic signalling pathway may presents important effects on epilepsy. In this study we cha

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10

Young, Helena. "Experiences of mental health professionals : patient suicide and working in a crisis team." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55965/.

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This research thesis explores mental health professionals’ reactions to patient suicide and the emotional experiences of working in a Crisis Team. Chapter one is a literature review examining twelve empirical studies of the impact of patient suicide on mental health professionals and the resources they draw on to cope with the effects. The review revealed a range of personal and professional responses amongst professionals and highlighted the concept of blame in the coping process. Chapter two is a qualitative empirical study of seven clinicians’ emotional experiences of working in a UK Crisis

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11

Nilsson, Louise. "The biodiversity loss crisis in Southeast Asia." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24000.

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Denna kandidatuppsats gör en ansats till att belysa biodiversitetsproblematiken i Sydostasien, som är ett område med mycket hög artrikedom som samtidigt hotas av en intensifierad förlust av arter. Fyra ’biodiversitet hotspots’ omger Sydostasien, vilka indikerar platser med hög artrikedom vilka sammanfaller med hög förlust av habitat. Det största orsaken till förlust av biologisk mångfald i Sydostasien är omvandlingen utav artrika naturtyper till monokulturodlingar, och expansionen av jordbruk och urbana områden. För att undersöka den pågående biodiversitetsforskningen genomfördes en systematis

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12

Siebel, Anna Maria. "Efeito de crises convulsivas e fármacos antiepilépticos em parâmetros neuroquímicos e moleculares em peixe zebra (Danio rerio)." Pontifícia Universidade Católica do Rio Grande do Sul, 2011. http://hdl.handle.net/10923/1323.

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Made available in DSpace on 2013-08-07T18:41:37Z (GMT). No. of bitstreams: 1 000431137-Texto+Completo-0.pdf: 15580738 bytes, checksum: 8de463b0a32f5623e6e47a0d1d0edad2 (MD5) Previous issue date: 2011<br>Epilepsy is a neurological disorder characterized by the occurrence of spontaneous and recurrent seizures. This disease and its treatment influence diverse neurological pathways. The purinergic system is an essential route for cell-to-cell communication and employs extracellular nucleotides and nucleosides as signaling molecules. The neurotransmitter ATP mediates synaptic currents through act

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13

Piza, Patrícia Bonilha de Toledo. "ANÁLISE GENÉTICA DOS VESTÍGIOS DE CRIMES SEXUAIS." Pontifícia Universidade Católica de Goiás, 2012. http://localhost:8080/tede/handle/tede/2342.

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Made available in DSpace on 2016-08-10T10:38:31Z (GMT). No. of bitstreams: 1 PATRICIA BONILHA DE TOLEDO PIZA.pdf: 970259 bytes, checksum: e296c4994d48ecfafd048f3cc57617e4 (MD5) Previous issue date: 2012-08-31<br>In Brazil sexual violence is a crime. Rape and vulnerable rape are heinous crimes. It is estimated that only 10% of rapes are recorded and the SENASP point 42.946 police incidents in 2010. Most victims are women aged below 14 years. The absence of expert evidence difficult the sentencing of the offender. In victim, exams corpus delicti of carnal knowledge and research of semen when p

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Gaspary, Karina Vidarte. "Mem?ria de reconhecimento e localiza??o de objetos em peixe-zebra (Danio rerio) : influ?ncia da sinaliza??o glutamat?rgica e respostas end?crinas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/8023.

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Submitted by PPG Biologia Celular e Molecular (bcm@pucrs.br) on 2018-04-24T12:44:41Z No. of bitstreams: 1 KARINA_VIDARTE_GASPARY_DIS.pdf: 1111674 bytes, checksum: e2b2dc4b1b1eea8b10007b7c07f592ec (MD5)<br>Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-05-11T17:57:10Z (GMT) No. of bitstreams: 1 KARINA_VIDARTE_GASPARY_DIS.pdf: 1111674 bytes, checksum: e2b2dc4b1b1eea8b10007b7c07f592ec (MD5)<br>Made available in DSpace on 2018-05-11T18:03:07Z (GMT). No. of bitstreams: 1 KARINA_VIDARTE_GASPARY_DIS.pdf: 1111674 bytes, checksum: e2b2dc4b1b1eea8b10007b7c07f5

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15

Vasseur, Raphaël. "Extinctions et recouvrements de coraux au cours de la crise Pliensbachien - Toarcien." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0204/document.

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Le passage entre les étages géologiques du Pliensbachien et du Toarcien au Jurassique inférieur est suivi au Toarcien inférieur par un évènement anoxique d’importance planétaire (TOAE pour Toarcian Oceanic Anoxic Event). Dans les archives de l’histoire de la terre, ce moment correspond en bien des endroits à un temps de fossilisation massive de matière organique donnant ici où là des roches mères d’intérêt pétrolier. Si, en termes de fluctuation du niveau eustatique, ces évènements sont souvent situés dans une zone d’inondation maximale de 2ème ordre, ils sont aussi interprétés comme une pertu

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16

Fleck, Juliana. "MONTELUCASTE DIMINUI AS CRISES CONVULSIVAS EM ANIMAIS ABRASADOS E POTENCIALIZA O EFEITO ANTICONVULSIVANTE DO FENOBARBITAL." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/3855.

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Epilepsy is a chronic neurological disease characterized by recurrent, unprovoked seizures. Evidence suggests that inflammation plays a role in the pathophysiology of seizures. Although cysteinyl leukotrienes (CysLTs) have been implicated in seizures, no study has investigated whether blocking of CysLT1 receptors potentiates the anticonvulsant action of classic antiepileptic drugs, as well as the expression of CysLT receptors is altered by inflammation. In this study we showed that the inverse agonist of CysLT1 receptor, montelukast, synergistically increases the anticonvulsant action of pheno

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Morris, Nicola Louise. "A grounded theory study of the experiences of clinical psychologists working in crisis resolution and home treatment teams." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/37452/.

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There has been a rapid development and implementation of Crisis Resolution Home Treatment Teams (CRHT) in the United Kingdom over the past decade. The available research studies of this service provision to date have largely focussed on issues related to the ‘outputs’ of CRHT, for example cost efficacy and the impact on admission rates. There is no available research on the experiences of clinical psychologists within CRHT. This is despite the fact that it would seem that research exploring the experiences of clinical psychologists in CRHT is important, as working in a new area of service prov

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Medeiros, Jo?o Paulo do Vale de. "Ecossocialismo: a g?nese de uma ecologia social em assentamentos de reforma agr?ria a partir dos movimentos sociais do campo." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18243.

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Made available in DSpace on 2014-12-17T15:55:03Z (GMT). No. of bitstreams: 1 JoaoPVM_DISSERT.pdf: 1440684 bytes, checksum: f894b737f60bc93063040e0cfaa91846 (MD5) Previous issue date: 2013-02-18<br>The world`s ecology crisis has in the capitalism way of production one of the possible causes. The unstopped search for the profits, into unlimited exploration of limited resources, made a huge transformation in human relationships with the nature, causing environment devastation, shortage of resources and species disappearance. Arises the necessity of question the society m

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Hoffmann, Mauricio Scopel. "AVALIAÇÃO DA SUPLEMENTAÇÃO DE CREATINA EM RATOS COM TRAUMATISMO CRANIOENCEFÁLICO SOBRE A SUSCETIBILIDADE A CRISES EPILÉPTICAS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/8985.

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Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul<br>This study presents an analysis on the effects of creatine supplementation on parameters of susceptibility to seizures induced by subconvulsant dose of pentylenetetrazol (PTZ) in an experimental rat model of traumatic brain injury (TBI). TBI is an acute neurological event that can lead to chronic neurological disease, such as epilepsy. Given the magnitude of the problem, various forms of therapy is being tested, but many have failed and yet, few take into account the susceptibility to seizures as an outcome and concentrate on a ve

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Decker, Richard E. Jr. "Production and Biocompatibility of Spider Silk Proteins in Goat Milk." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7288.

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Due to its strength, flexibility, and biocompatibility, spider silk is a highly appealing material for applications in the medical field. Unfortunately, natural spider silk is difficult to obtain in large quantities because spiders are territorial and cannibalistic, making them impractical to farm. Synthetic spider silk proteins produced by transgenic hosts such as bacteria and goats have made it possible to obtain the quantities of spider silk needed to study it more fully and to investigate its potential uses. The spider silk proteins produced in our laboratory do not have an optimal purific

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Ruiz, Karine Pequeno Nakao. "Análise molecular de amostras negativas para o antígeno específico da próstata (PSA) coletadas de vítimas de crimes sexuais." Universidade Federal da Paraíba, 2017. http://tede.biblioteca.ufpb.br:8080/handle/tede/9469.

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Submitted by Vasti Diniz (vastijpa@hotmail.com) on 2017-09-08T14:06:42Z No. of bitstreams: 1 arquivototal.pdf: 2742380 bytes, checksum: cf8f43acdec2329a5d6d78a8a373b6b7 (MD5)<br>Made available in DSpace on 2017-09-08T14:06:42Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2742380 bytes, checksum: cf8f43acdec2329a5d6d78a8a373b6b7 (MD5) Previous issue date: 2017-04-20<br>The finding of sperm through the screening tests on samples collected from rape victims confirms the occurrence of the sexual act, but its absence usually closes biological research in the crime in question, leaving a gap abou

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Gould, Chandré. "South Africa's chemical and biological warfare programme 1981-1995." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1002396.

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In 1981 the apartheid military initiated a chemical and biological warfare (CBW) programme (code-named Project Coast). The programme, terminated in 1993, was aimed at developing novel irritating and incapacitating agents for internal and external use, covert assassination weapons for use against apartheid opponents, and defensive equipment for use by South African Defence Force (SADF) troops in Angola. The CBW programme was driven by a single individual, Dr Wouter Basson, who reported to a military management committee (the Co-ordinating Management Committee) which comprised a select group of

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Taufer, Clarissa Reginato. "Avaliação da diferenciação de células da crista neural de aves sobre matrizes de PuraMatrix." reponame:Repositório Institucional da UFSC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/180701.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2017.<br>Made available in DSpace on 2017-11-07T03:25:46Z (GMT). No. of bitstreams: 1 347991.pdf: 3464947 bytes, checksum: 4b9adce4d95c51c30b0828be864fb06e (MD5) Previous issue date: 2017<br>A crista neural (CN) é composta por células heterogêneas e multipotentes, e pode ser dividida em CN cefálica (CNC) e truncal (CNT). As células da CNC originam, in vivo, células neurais e mesenquimais, neste último caso, formando

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Reschke, Cristina Ruedell. "RECEPTORES EP1 E EP3 MODULAM AS CRISES EPILÉPTICAS INDUZIDAS POR PENTILENOTETRAZOL E ÁCIDO CAÍNICO EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3852.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Epilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. The

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Vasseur, Raphaël. "Extinctions et recouvrements de coraux au cours de la crise Pliensbachien - Toarcien." Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0204.

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Le passage entre les étages géologiques du Pliensbachien et du Toarcien au Jurassique inférieur est suivi au Toarcien inférieur par un évènement anoxique d’importance planétaire (TOAE pour Toarcian Oceanic Anoxic Event). Dans les archives de l’histoire de la terre, ce moment correspond en bien des endroits à un temps de fossilisation massive de matière organique donnant ici où là des roches mères d’intérêt pétrolier. Si, en termes de fluctuation du niveau eustatique, ces évènements sont souvent situés dans une zone d’inondation maximale de 2ème ordre, ils sont aussi interprétés comme une pertu

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Merisio, Paulo Roberto. "Avaliação de marcadores de lesão endotelial nas crises vasoclusivas das doenças falciformes / Paulo Roberto Merisio ; orientadora, Mara Albonei Dudeque Pianovski." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2012. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=2453.

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Dissertação (mestrado) - Pontifícia Universidade Católica do Paraná, Curitiba, 2012<br>Bibliografia: f. 50-61<br>Pacientes com doenca falciforme podem apresentar crises clinicas que prejudicam sua qualidade de vida. Com o intuito de contribuir para o conhecimento da fisiopatologia foi desenvolvido o presente trabalho tendo como objetivo analisar marcadores endotelia<br>Patients with sickle cell disease may have clinical seizures that impair their life quality. The aim of this study was to analyze endothelial markers in children and adolescents with sickle cell disease in order to contribute to

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O’Brien, Colleen. "DARK EMBRACE: ORESTES COMPLEX, CATATHYMIC CRISIS AND METHOD OF MURDER. A STUDY OF MATRICIDE IN A FORENSIC PSYCHIATRIC SAMPLE." Thesis, Laurentian University of Sudbury, 2014. https://zone.biblio.laurentian.ca/dspace/handle/10219/2197.

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A study was conducted to investigate and identify differences inherent in two subtypes of psychosis driven or mentally disordered homicide: matricide versus any other biological intrafamilial homicide or attempted homicide. Matricide was further investigated through the exploration of offence specific details, as well as demographic and diagnostic characteristics of persons who had committed (or attempted) homicide against the mother and were subsequently found not criminally responsible and detained by the Ontario Review Board between 1992 and 2012. Matricidal accused were more often diagnose

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Schwengber, Solange Pereira. "Utilização de marcadores de cromossomo Y como ferramenta visando a elucidação de casos de crimes sexuais na genética forense." Pontifícia Universidade Católica do Rio Grande do Sul, 2008. http://hdl.handle.net/10923/1360.

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Made available in DSpace on 2013-08-07T18:41:47Z (GMT). No. of bitstreams: 1 000405027-Texto+Parcial-0.pdf: 58857 bytes, checksum: 3137651cc6ea0e3ba8d2644d92086797 (MD5) Previous issue date: 2008<br>Marcadores moleculares de cromossomo Y são essenciais à perícia em genética forense. Os marcadores moleculares STR (Short Tandem Repeats) específicos para o cromossomo Y são amplamente utilizados nos Laboratórios de Perícias. Entretanto, não havia dados estatísticos próprios do Estado do Rio Grande do Sul, implicando na utilização de bancos de dados alternativos (brasileiro e europeu). Assim, a f

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Younis, Shady. "Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329190.

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The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. A mutation in the binding site of ZBED6, located in an intron of IGF2, disrupts the binding and leads to 3-f

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Valladares, Rodrigo, and Hanna Briheim. "Metoder och tillämpningar av CRISPR-Cas9 i cancerforskning. : Samt hur CRISPR-Cas9 kan implementeras i skolundervisningen." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166140.

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CRISPR-Cas9 är ett effektivt genredigeringsverktyg som har upptäckts på senare år. Verktyget härstammar från ett adaptivt immunförsvar hos prokaryoter. Tekniken används för att modifiera DNA hos växter, djur och människor på ett enkelt och billigt sätt. CRISPR-Cas9 har visat sig ha stor potential vid bekämpning av olika sjukdomar däribland cancer som idag är ett globalt hälsoproblem. Inom cancerforskningen ses CRISPR-Cas9 som ett lovande verktyg vid cancerterapi och läkemedelsutveckling. I denna studie sammanställer vi aktuella metoder och användningsområden med CRISPR-Cas9 inom cancerforsknin

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Pereira, Charlane Kelly Souto. "Estudo da ação psicofarmacológica de Herissantia crispa (L.) Brizicky (Malvaceae)." Universidade Federal da Paraíba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/6761.

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Made available in DSpace on 2015-05-14T12:59:45Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 884408 bytes, checksum: 448afd42d1cb8f67ef7beee9503e0735 (MD5) Previous issue date: 2009-11-11<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Herissantia crispa (L.) Brizicky popularly know as malvaísco is a plant which belongs to the Malvaceae family. There aren t many reports about H. crispa, however, steroids, flavonoids and glycosidic flavonoids with pharmacological activity have been isolated from this species. Other species of Malvaceae have been used in traditional medicin

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Ramos, Hryb Ana Belén. "Avaliação do potencial de diferenciação das células da crista neural truncal de aves cultivadas sobre Matrigel." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/106862.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2013.<br>Made available in DSpace on 2013-12-05T22:35:37Z (GMT). No. of bitstreams: 1 320037.pdf: 1679970 bytes, checksum: ef7c5e9994dac949503795a373ca9fb2 (MD5) Previous issue date: 2013<br>A Crista Neural (CN) constitui uma população de células que emergem a partir das pregas dorsais do neuroepitélio durante a neurulação. Estas células migram ao longo de todo o eixo antero-posterior embrionário dos vertebrados até

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Paladini, L. "BIOLOGICAL SIGNIFICANCE OF ALTERATIONS IN BRCA1 AND BRCA2 GENES AND RESPONSE TO DNA DAMAGE AGENTS IN HEREDITARY BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/488444.

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Background: Although the large number of studies investigating BRCA mutations and their clinical role in different populations and ethnicities, there is a lack of a systematic analysis on these alterations in Italian cohorts, including the analysis of Variants of Unknown biological and clinical Significance (VUS). Moreover, correct management of breast cancer patients tested positive for alterations in BRCA1 or BRCA2 genes is still controversial. We aimed to assess the biological and clinical relevance of BRCA alterations in a consecutive cohort of hereditary breast cancer patients, with parti

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Pereira, Charlane Kelly Souto. "Atividade antinociceptiva e anti-inflamatória de Herissantia crispa (L.) Brizicky em camundongos." Universidade Federal da Paraíba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6820.

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Made available in DSpace on 2015-05-14T13:00:02Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1186433 bytes, checksum: a2657e7816d226f92f3431c0227b0dbc (MD5) Previous issue date: 2013-09-09<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The Herissantia crispa (L.) Brizicky (Malvaceae), is composed of substances that have proven activities, such as anti-inflammatory, antinociceptive and antioxidant. There are few reports in the literature of this plant, but previous studies have determined, that H.crispa characteristics of drugs with antinociceptive and sedative-

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Ferreira, Diana Aline N?ga Morais. "Efeito anticonvulsivante de fra??es isoladas da pe?onha da formiga Dinoponera quadriceps (Formicidae: Ponerinae)." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20246.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-15T21:41:00Z No. of bitstreams: 1 DianaAlineNogaMoraisFerreira_DISSERT.pdf: 1601671 bytes, checksum: 0d50d44c04af4da6c6dd76cda2792325 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-20T00:00:50Z (GMT) No. of bitstreams: 1 DianaAlineNogaMoraisFerreira_DISSERT.pdf: 1601671 bytes, checksum: 0d50d44c04af4da6c6dd76cda2792325 (MD5)<br>Made available in DSpace on 2016-04-20T00:00:50Z (GMT). No. of bitstreams: 1 DianaAlineNogaMoraisFerreira_DISSERT.pdf: 1601671 bytes, che

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Lenz, Quéli Fernandes. "Envolvimento dos receptores CysLT1 nas crises induzidas por pentilenotetrazol em camundongos, na permeabilidade da barreira hematoencefálica e na modulação da enzima na+,k+-ATPase em hipocampo." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/3844.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Growing evidence has shown that leukotrienes are important contributors in the pathophysiology of several SNC inflammatory diseases where excitotoxicity is involved, including traumatic brain injury, encephalitis, Parkinson's disease, ischemia, epilepsy and neuropathic pain. However little is known about the molecular mechanism by which leukotrienes facilitate excitatory activity in the brain. Thus, in this study we investigated the effect of antagonists for cysteinyl leukotrienes receptors (CysLT) on PTZ-induced seizure in mice. B

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Teixeira, Bianca Luise. "Efeitos do fator de crescimento epidermal (EGF) na potencialidade e diferenciação das células da crista neural de aves." Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/95368.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2011<br>Made available in DSpace on 2012-10-26T00:43:50Z (GMT). No. of bitstreams: 1 296293.pdf: 595442 bytes, checksum: 4a44716096b914945e724217369d1213 (MD5)<br>A crista neural (CN) é uma população de células originadas das margens dorsais do tubo neural durante o desenvolvimento de vertebrados. Essas células possuem um alto potencial migratório e dão origem a múltiplos fenótipos como neurônios, células gliais, mela

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L?pez, Christian Camilo Garc?a. "Livre-arb?trio? Fatores psiconeuroend?crinos envolvidos no processo de tomada de decis?o sob risco em homens adultos jovens." PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/24442.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-12-04T20:41:47Z No. of bitstreams: 1 ChristianCamiloGarciaLopez_DISSERT.pdf: 2196830 bytes, checksum: 3aec0c3604ab6bb915398d3380ba6a61 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-12-07T19:26:20Z (GMT) No. of bitstreams: 1 ChristianCamiloGarciaLopez_DISSERT.pdf: 2196830 bytes, checksum: 3aec0c3604ab6bb915398d3380ba6a61 (MD5)<br>Made available in DSpace on 2017-12-07T19:26:20Z (GMT). No. of bitstreams: 1 ChristianCamiloGarciaLopez_DISSERT.pdf: 2196830 bytes, checksum:

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DI, LILLO ALESSIA. "CAN A PRECISELY-POSITIONED DNA DOUBLE-STRAND BREAK (DSB) ACTIVATE GENE EXPRESSION?" Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/884393.

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Our group previously demonstrated that when a DNA double-strand break (DSB) occurs, RNA polymerase II (RNAPII) is recruited to the exposed DNA ends and allows the by-directional synthesis of transcripts derived from exposed DNA ends that we called damage-induced long non-coding RNAs (dilncRNAs). Recently we reported that a DSB also recruits the full transcriptional machinery, in particular the preinitiation complex (PIC), just as commonly recruited at canonical RNA polymerase II-driven transcriptional promoters. This, blurs the distinction between a DSB and a transcriptional promoter. dilncRN

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Licon, Ana Laura. "Spiderworms: Using Silkworms as Hosts to Produce a Hybrid Silkworm-Spider Silk Fiber." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7591.

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Spider silk has received significant attention due to its fascinating mechanical properties. Given the solitary and cannibalistic behavior of spiders, spider silk farming is impractical. Unlike spiders, silkworms are capable of producing large quantities of a fibrous product in a manner mimetic to spiders, and there already exists an industry to process cocoons into threads and textiles for many applications. The combination of silk farming (sericulture), a millennia old practice, and modern advancements in genetic engineering has given rise to an innovative biomaterial inspired by nature; tra

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Janin, Grajcarek. "Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations." Kyoto University, 2020. http://hdl.handle.net/2433/253215.

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TAVELLA, SARA. "WEAPONIZING CRISPR/CAS9." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/908993.

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One of the major limits of current therapies against cancer and viral infections is the nonspecific toxicity that they often cause on healthy tissues because of their impact on important cellular mechanisms shared, to different extents, between diseased and healthy cells. For this reason, there is an unmet need for more specific and more effective therapies. Wherefore, the aim of my project is the development of a novel strategy, with potential for therapy, that allows the induction of sequence-specific DNA lesions (DNA double-strand break, DSB), by the use of the CRISPR/Cas9 system targ

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Soardi, Michela. "Generation of novel zebrafish models of sarcoglycanopathy." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426362.

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Sarcoglycanopathy is the collective name of four rare autosomal recessive diseases belonging to the limb-girdle muscular dystrophies type 2 (LGMD2C-F), due to mutations in SGCG, SGCA, SGCB, SGCD genes coding for γ-, α-, β- and δ- sarcoglycan (SG) respectively. SGs form a tetrameric sub-complex on the sarcolemma, closely linked to the dystrophin associated protein complex (DAPC) and play an essential role in assuring membrane integrity during muscle contraction (Bushby, 2009). Mutations in each SG gene cause the loss/reduction of the mutated protein as well as of the wild type (WT) partners wit

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Stringa, Blerta. "The effect of germline variants on the genesis of early somatic events in cancer explored via Cas9 genome editing." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/242372.

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Although the understanding of genetic predisposition to prostate cancer (PCa) has been improved through genome-wide association studies (GWAS), little is known about the biological implication of germline variants residing in coding or non-coding regions in cancer development and progression. Our hypothesis is that inherited variants may predispose to specific early recurrent genomic events observed in PCa adenocarcinomas, possibly in the context of variable androgen receptor (AR) signaling that changes during a man’s lifetime. Recent in silico analysis by our group on potential association b

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Stringa, Blerta. "The effect of germline variants on the genesis of early somatic events in cancer explored via Cas9 genome editing." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/242372.

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Although the understanding of genetic predisposition to prostate cancer (PCa) has been improved through genome-wide association studies (GWAS), little is known about the biological implication of germline variants residing in coding or non-coding regions in cancer development and progression. Our hypothesis is that inherited variants may predispose to specific early recurrent genomic events observed in PCa adenocarcinomas, possibly in the context of variable androgen receptor (AR) signaling that changes during a man’s lifetime. Recent in silico analysis by our group on potential association b

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Stens, Cassandra, Isabella Enoksson, and Sara Berggren. "The CRISPR-Cas system." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171997.

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Derived from and inspired by the adaptive immune system of bacteria, CRISPR has gone from basic biology knowledge to a revolutionizing biotechnological tool, applicable in many research areas such as medicine, industry and agriculture. The full mechanism of CRISPR-Cas9 was first published in 2012 and various CRISPR-Cas systems have already passed the first stages of clinical trials as new gene therapies. The immense research has resulted in continuously growing knowledge of CRISPR systems and the technique seems to have the potential to greatly impact all life on our planet. Therefore, this li

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RUBOLINO, CARMELA. "NEW FINDINGS INTO TARGET-DIRECTED MICRORNA DEGRADATION MECHANISM." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/945228.

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MiRNAs are a class of small non-coding RNAs that function in post-transcriptional gene silencing by interacting with target RNAs. A novel mechanism in control of miRNA levels, called Target-Directed miRNA degradation (TDMD), has been described, which involves specific transcripts able to interact with miRNAs and induce miRNA degradation. We showed that an endogenous RNA transcript, Serpine1, uses TDMD to control levels and activity of miR:30b/c in murine fibroblasts. It is unknown how many other TDMD transcripts exist; therefore, we developed TDMDfinder, a computational pipeline and free webto

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RICCI, RAFFAELE. "Activatory CRISPR/dCa9 as a therapeutic strategy in Dravet Syndrome." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365223.

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La sindrome di Dravet (SD) è una encefalopatia epilettica dello sviluppo, caratterizzata da crisi convulsive farmaco-resistenti e un alto rischio di morte improvvisa durante le crisi. L'80% dei pazienti presenta mutazioni eterozigoti sul gene SCN1A, con conseguente perdita della sua funzionalità, indicando che un meccanismo di aploinsufficienza sia alla base dell'insorgenza della patologia. SCN1A codifica per la subunità alfa del canale del sodio voltaggio-dipendente Nav1.1, essenziale per la generazione del potenziale d'azione (PA) negli interneuroni gabaergici (ING).Analisi di modelli animal

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DE, FLORIAN FANIA ROSSELLA. "Identification and characterization of therapeutic molecules affecting expression levels of the tumor suppressor DAB2IP in cancer." Doctoral thesis, Università degli Studi di Trieste, 2023. https://hdl.handle.net/11368/3042421.

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In tumors, the reciprocal communication between malignant cells and non-transformed stromal cells involves a variety of signaling proteins and modulators that cooperate to control proliferation, migration and apoptosis. Among them, the tumor suppressor DAB2IP, a Ras-GAP and signaling adaptor protein, modulates signal transduction in response to several extracellular stimuli, negatively regulating multiple oncogenic pathways. Accordingly, the loss of DAB2IP in tumor cells fosters metastasis and enhances chemo- and radio-resistance. DAB2IP is rarely mutated in cancer but is frequently downregula

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Souza, Gustavo Torres de. "Produção de células MDBK expressando a enzima CAS9 e edição do gene da beta-lactoglobulina pelo sistema CRISPR/Cas9." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/6049.

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