Academic literature on the topic 'Biological heterogeneity'

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Journal articles on the topic "Biological heterogeneity"

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Rogina, Blanka. "Biological Heterogeneity." Innovation in Aging 4, Supplement_1 (2020): 854–55. http://dx.doi.org/10.1093/geroni/igaa057.3145.

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Abstract Studies of aging in invertebrates, mammalian animal models and humans have demonstrated increasing heterogeneity with aging in terms of varied facets of biological aging. In addition to growing heterogeneity, aging is also associated with qualitative and quantitative changes involving DNA methylation captured in epigenetic clocks of aging which seek to predict chronological and biological aging. Increased heterogeneity with aging is also evident in terms of posttranslational histone modification, gene expression, somatic clonal expansion, and increased degree of tissue mosaicism. Sene
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Fidler, Isaiah J. "Biological heterogeneity of cancer." Human Vaccines & Immunotherapeutics 8, no. 8 (2012): 1141–42. http://dx.doi.org/10.4161/hv.19643.

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Harrison, G. Ainsworth. "Social Heterogeneity and Biological Variation." Man 23, no. 4 (1988): 740. http://dx.doi.org/10.2307/2802602.

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Rubin, Harry. "The significance of biological heterogeneity." CANCER AND METASTASIS REVIEW 9, no. 1 (1990): 1–20. http://dx.doi.org/10.1007/bf00047585.

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Hiyama, E., and K. Hiyama. "Molecular and Biological Heterogeneity in Neuroblastoma." Current Genomics 6, no. 5 (2005): 319–32. http://dx.doi.org/10.2174/1389202054750202.

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Friedland, Robert P. "Alzheimer Disease: Clinical and Biological Heterogeneity." Annals of Internal Medicine 109, no. 4 (1988): 298. http://dx.doi.org/10.7326/0003-4819-109-4-298.

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Scanu, A. M., and G. M. Fless. "Lipoprotein (a). Heterogeneity and biological relevance." Journal of Clinical Investigation 85, no. 6 (1990): 1709–15. http://dx.doi.org/10.1172/jci114625.

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Gerashchenko, T. S., E. V. Denisov, N. V. Litviakov, et al. "Intratumor heterogeneity: Nature and biological significance." Biochemistry (Moscow) 78, no. 11 (2013): 1201–15. http://dx.doi.org/10.1134/s0006297913110011.

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Pu, Kyle Z., Zixuan Wang, and David Whitney. "Spatial Heterogeneity of Biological Motion Perception." Journal of Vision 21, no. 9 (2021): 2179. http://dx.doi.org/10.1167/jov.21.9.2179.

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Weiss, Paul S. "Nanoscience approaches to heterogeneity in biological systems." Nanomedicine: Nanotechnology, Biology and Medicine 14, no. 5 (2018): 1755. http://dx.doi.org/10.1016/j.nano.2017.11.053.

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Dissertations / Theses on the topic "Biological heterogeneity"

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Hodgkinson, Arran. "Mathematical Methods for Modelling Biological Heterogeneity." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS119.

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Les processus biologiques sont des phénomènes complexes, multi-échelles, présentant une hétérogénéité importante à travers l’espace, la structure et la fonction. De plus, ils impliquent des événements fortement corrélés et présentent des boucles de rétroaction à travers les échelles. Dans cette thèse, nous utilisons des représentations spatio-structuro-temporelles en grande dimension pour étudier l'hétérogénéité biologique à travers l'espace, la fonction biologique et le temps, et appliquons cette méthode à divers problèmes importants en biologie et en clinique.Nous commençons par introduire u
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Au, Y. C. "Synthesising heterogeneity : trends of visuality in biological sciences, circa 1970s-2000s." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1478180/.

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This is a case study of diagrams in a field of biological mechanism research (apoptosis), revealing that mechanism diagrams play a crucial role in the practice of developing mechanistic explanations for cell biology. This thesis supports and extends the existing literature in the following aspects: the relationship between scientific representation and practice (Daston and Galison, 2007), inter-field and inter-level integration in biological practice of mechanism research (Bechtel, 2006; Craver and Darden, 2013), and the assertive and engaging power of diagrams (Bender and Marrinan, 2010; Wood
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Mahajan, Vinay Subhash. "Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61227.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 125-137).<br>This thesis describes the identification and characterization of a novel 'layer' of intrinsic non-genetic functional heterogeneity within the seemingly homogeneous naive CD8⁺ T cell population in their survival and proliferation capacities. This heterogeneity is predictably marked by the surface level of CD5. NaYve CD8⁺ T cells that are also CD5hi have a greater intrinsic capacity to proliferate both in r
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Kendall, Bruce Edward. "Spatial structure and transient periodicity in biological dynamics." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187496.

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Structure, in its many forms, is a central theme in theoretical population ecology. At a mathematical level, it arises as nonuniformities in the topology of nonlinear dynamical systems. I investigate a mechanism wherein a chaotic time series can have episodes of nearly periodic dynamics interspersed with more 'typical' irregular dynamics. This phenomenon frequently appears in biological models, and may explain patterns of alternating biennial and irregular dynamics in measles epidemics. I investigate the interaction between spatial structure and density-dependent population regulation with a s
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Reid, Michael Steven. "The Role of Heterogeneity in Rhythmic Networks of Neurons." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14565.

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Engineers often view variability as undesirable and seek to minimize it, such as when they employ transistor-matching techniques to improve circuit and system performance. Biology, however, makes no discernible attempt to avoid this variability, which is particularly evident in biological nervous systems whose neurons exhibit marked variability in their cellular properties. In previous studies, this heterogeneity has been shown to have mixed consequences on network rhythmicity, which is essential to locomotion and other oscillatory neural behaviors. The systems that produce and control thes
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du, Plessis Darren Scott. "Temporal interactions with flamingo foraging plasticity: ecological effects on basal resources and benthic heterogeneity." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29623.

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The role of predation as a structuring agent of communities has been a focal area of research in marine ecology. Conversely, studies focusing on foraging plasticity, particularly by shorebirds, and consequences for benthic community structure, heterogeneity and ecosystem functioning have been limited in marine soft-sediments. Temporal interactions with foraging plasticity is an even greater knowledge gap. The primary goal of this dissertation was to expand on current understanding of foraging plasticity and the broader ecological role of Greater Flamingos as predators in marine sedimentary eco
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Donnelly, Robert Kevin. "An investigation of genetic heterogeneity in a biological sentinel species (Lumbricus rubellus)." Thesis, University of South Wales, 2011. https://pure.southwales.ac.uk/en/studentthesis/an-investigation-of-genetic-heterogeneity-in-a-biological-sentinel-species-lumbricus-rubellus(ab114364-d43b-49c2-b309-6cecd95dcaf2).html.

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Studies have indicated the existence of several possible sources of genetic heterogeneity within the sentinel species Lumbricus rubellus that could compromise its suitability for ecotoxicological assessment. The species appears to consist of two genetically divergent cryptic lineages and has been demonstrated to display genetic adaptation towards contaminants within some populations. In order to investigate the cryptic lineages of L rubellus further a combined morphological and DNA barcoding approach was undertaken, with both the mitochondria! COI gene being sequenced and external morphologica
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Parry-Jones, Nilima. "The clinical and biological heterogeneity of mantle cell lymphoma presenting with leukaemia." Thesis, Institute of Cancer Research (University Of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408862.

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Rennerfeldt, Deena Antoinette. "Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121873.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their demonstrated differentiation potential toward several lineages, but also due to the anti-inflammatory and immunomodulatory
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Habashy, Hany Onsy Fouad Ibrahim. "The biological heterogeneity of oestrogen receptor positive breast cancer and its phenotypic characterisation." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/29131/.

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Although global gene microarray studies have demonstrated the molecular heterogeneity of breast cancer (BC) and provided potential for clinical applications, the molecular subclassification of luminal/ER-positive tumours, which is the largest class of BC, remains unclear. Characterisation of luminal/ER-positive subtypes could have important implications in clinical decision-making and patient management. The patient study cohort is derived from a consecutive series of approximately 1902 cases of primary operable invasive breast carcinoma obtained from the Nottingham Tenovus Primary Breast Carc
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Books on the topic "Biological heterogeneity"

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Oliver, Caldecott Julian, and World Conservation Monitoring Centre, eds. Priorities for conserving global species richness and endemism. World Conservation Press, 1994.

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Libon, David J., Melissa Lamar, Rodney A. Swenson, and Kenneth M. Heilman, eds. Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190634230.001.0001.

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Alzheimer’s disease and vascular dementia are acknowledged as the two most common types of dementia. Each of these dementia syndromes are associated with prodromal clinical syndromes, often referred to as mild cognitive impairment. Recent research has demonstrated considerable heterogeneity regarding the underlying neuropathology associated with these dementia syndromes and their prodromal disorders. Thus, it is often difficult to understand how or what underlying biological substrate is actually responsible for the alterations in neurocognition and behaviour as seen in clinical evaluations. T
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Jinnah, H. A., Cecilia N. Prudente, Samuel J. Rose, and Ellen J. Hess. The Neurobiology of Dystonia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0010.

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The dystonias are a large group of disorders characterized by excessive muscle activity leading to abnormal movements. They are clinically diverse, affecting different parts of the body at all ages in both humans and other animals. They also are etiologically diverse, with causes that are either inherited due to specific dystonia-causing genes, or acquired because of nervous system injury or exposure to certain drugs or chemicals. Despite the clinical and etiological heterogeneity, there is an increasing appreciation that certain subgroups of dystonias share some biological abnormalities at th
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Ferraro, Kenneth F. Ageism. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190665340.003.0007.

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Negative views of aging are pervasive and pernicious, and arise, in part, from a failure to recognize the heterogeneity of the older adult population. Many people, at various ages, view the aging process pejoratively, thereby exaggerating the declines associated with growing older, Ageism also may entail unfair treatment toward older people, often manifest as neglect and exclusion. The consequences of ageism are notable, including accelerated declines in biological, psychological, and social functioning as well as ignoring or minimizing the intellectual and creative potential of older adults.
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Mann, Heřman, and Jiří Vencovský. Treatment of the idiopathic inflammatory myopathies. Edited by Hector Chinoy and Robert Cooper. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198754121.003.0017.

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The management of idiopathic inflammatory myopathies (IIM) poses a challenge due to disease heterogeneity, variable responses to treatment and limited data from controlled studies. High dose glucocorticoids, often combined with other immunosuppressive drugs, represent the most common pharmacotherapeutic approach. The importance of early commencement of supervised exercise is also stressed. In treatment resistant cases, the introduction of drug combinations is recommended, and intravenous immunoglobulins may also be effective. Currently available data do not support use of most biological agent
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Bargiotas, Theodoros. The Aetiology of Depression. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801900.003.0005.

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This chapter discusses the aetiology of depression. It begins with an overview of reasons why the aetiology of depression has been and still is difficult to define, including its heterogeneity and the wider philosophical and methodological challenges involved. It then considers life events and social determinants of depression as well as psychological factors relevant to depression, including childhood development and early experiences, parenting style, and personality and personality disorders. It also examines cognitive behavioural theories of depression, neuropsychology, and psychodynamic t
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Bohon, Cara. Research Domain Criteria. Edited by W. Stewart Agras and Athena Robinson. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190620998.013.2.

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A primary goal of the research domain criteria (RDoC) project from the National Institute of Mental Health in the United States is to better characterize and understand the pathology and etiology of mental illness by examining constructs with biological underpinnings and their effects on psychiatric symptoms. This endeavor shows promise in helping to better conceptualize dysfunction in the field of eating disorders, where there appears to be great heterogeneity within diagnostic groups. Treatments designed for a particular diagnosis may result in improved remission rates if they instead target
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Baune, Bernhard T., and Catherine Harmer, eds. Cognitive Dimensions of Major Depressive Disorder. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198810940.001.0001.

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The lifetime prevalence of 15% for major depressive disorder (MDD) within the general population is among the highest among all mental disorders. MDD is also one of the leading causes of disability and has been estimated to affect 300 million people worldwide. Clinical, functional, and biological correlates of MDD are frequently investigated almost exclusively based on research that defines depression as a categorical disorder assessed by established diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, a refocus of the clinical phenotype of depression is req
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With, Kimberly A. Essentials of Landscape Ecology. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198838388.001.0001.

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Essentials of Landscape Ecology is a new, comprehensive text that presents the principles, theory, methods, and applications of landscape ecology in an engaging and accessible format, supplemented by numerous examples and case studies from a variety of systems, including freshwater and marine “scapes.” Human activity has transformed landscapes worldwide on a scale that rivals or exceeds even the largest of natural forces, giving rise to a new geological age, the Anthropocene. As humans alter the structure and function of landscapes, the biological diversity and ecological relationships within
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Hüttemann, Andreas, and Alan Love. Reduction. Edited by Paul Humphreys. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199368815.013.26.

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Reduction and reductionism have been central philosophical topics in analytic philosophy of science for more than six decades. Together they encompass a diversity of issues from metaphysics and epistemology. This article provides an introduction to the topic that illuminates how contemporary epistemological discussions took their shape historically and limns the contours of concrete cases of reduction in specific natural sciences. The unity of science and the impulse to accomplish compositional reduction in accord with a layer-cake vision of the sciences, the seminal contributions of Ernest Na
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Book chapters on the topic "Biological heterogeneity"

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Navas-Moreno, Maria, and James W. Chan. "Laser Tweezers Raman Microspectroscopy of Single Cells and Biological Particles." In Cellular Heterogeneity. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7680-5_13.

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Downing, John A. "Biological Heterogeneity in Aquatic Ecosystems." In Ecological Studies. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3062-5_9.

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Slocum, Harry K., Gloria H. Heppner, and Youcef M. Rustum. "Cellular Heterogeneity of Human Tumors." In Biological Responses in Cancer. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-1236-9_8.

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Brown, Daniel V., Stanley S. Stylli, Andrew H. Kaye, and Theo Mantamadiotis. "Multilayered Heterogeneity of Glioblastoma Stem Cells: Biological and Clinical Significance." In Stem Cells Heterogeneity in Cancer. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14366-4_1.

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Bell, Duncan H. "Determinations of Functional Heterogeneity in Proteoliposomes." In Recent Advances in Biological Membrane Studies. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4979-2_9.

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Kim, Untae. "Factors Influencing the Generation of Phenotypic Heterogeneity in Mammary Tumors." In Biological Responses in Cancer. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-1236-9_5.

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Baykeev, R. F., and A. V. Filippov. "Dynamic Heterogeneity of Lipids in the Ether-Lecithin-Water System." In Spectroscopy of Biological Molecules. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0371-8_177.

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Maire, I., and P. Guibaud. "Type 3 Gaucher Disease: Clinical and Biological Heterogeneity." In Lipid Storage Disorders. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1029-7_11.

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Kim, Yoo-Ah. "Network Module Detection to Decipher Heterogeneity of Cancer Mutations." In Recent Advances in Biological Network Analysis. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57173-3_7.

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Leligdowicz, A., and M. A. Matthay. "Heterogeneity in Sepsis: New Biological Evidence with Clinical Applications." In Annual Update in Intensive Care and Emergency Medicine 2019. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-06067-1_40.

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Conference papers on the topic "Biological heterogeneity"

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Trofimova, M. S., M. S. Piotrovsky, and N. K. Lapshin. "Lateral heterogeneity of biological mebranes." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-440.

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Ragoonanan, Vishard, and Alptekin Aksan. "Quantification of Heterogeneity in Desiccating Droplets." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176250.

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Desiccated state biostabilization aims at stopping molecular motions and biochemical processes to halt degradation and to preserve functionality. Preservation by desiccation typically involves drying the biological material or the organism in a preservation solution, which typically contains non-reducing sugars (trehalose, sucrose, etc.) and salts [1]. Typically, preservation solutions (containing the biological material to be preserved) in the form of sessile droplets are deposited and dried on a surface in a controlled environment.
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Luboschik, Martin, Carsten Maus, Hans-Jorg Schulz, Heidrun Schumann, and Adelinde Uhrmacher. "Heterogeneity-based guidance for exploring multiscale data in systems biology." In 2012 IEEE Symposium on Biological Data Visualization (BioVis). IEEE, 2012. http://dx.doi.org/10.1109/biovis.2012.6378590.

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Calim, Ali, Muhammet Uzuntarla, and Mahmut Ozer. "Effects of heterogeneity on information processing in biological neural networks." In 2014 22nd Signal Processing and Communications Applications Conference (SIU). IEEE, 2014. http://dx.doi.org/10.1109/siu.2014.6830648.

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Wlodarczyk, Jakub, and Borys Kierdaszuk. "A New Approach to Interpretation of Heterogeneity of Fluorescence Decay in Complex Biological Systems." In European Conference on Biomedical Optics. OSA, 2005. http://dx.doi.org/10.1364/ecbo.2005.the7.

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Xu, Nan, Yunye Gong, Yili Zheng, Qiu Wang, and Peter C. Doerschuk. "3-D statistical characterization of the heterogeneity of biological macromolecular complexes by electron microscopy." In Signal Recovery and Synthesis. OSA, 2014. http://dx.doi.org/10.1364/srs.2014.stu3f.4.

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Wlodarczyk, Jakub, and Borys Kierdaszuk. "A new approach to interpretation of heterogeneity of fluorescence decay in complex biological systems." In European Conference on Biomedical Optics 2005, edited by Mary-Ann Mycek. SPIE, 2005. http://dx.doi.org/10.1117/12.633038.

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Moazed, F., C. M. Hendrickson, A. Jauregui, et al. "Cigarette Smoking Is Associated with Clinical and Biological Heterogeneity in Patients with the Acute Respiratory Distress Syndrome." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2710.

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Sigmans, Jessica, Willy Noort, Coleman Lindsley, et al. "Abstract PR12: Biological insights into tumor-bone marrow microenvironment interactions derived from a humanized murine model." In Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; February 26 — March 1, 2014; San Diego, CA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.chtme14-pr12.

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Endris, Volker, Michael Allgäuer, Jan Budczies, et al. "Abstract 4101: Spatial heterogeneity of tumor mutational burden (TMB) counts in pulmonary adenocarcinoma: Separating biological effects from technical artifacts." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4101.

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Reports on the topic "Biological heterogeneity"

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Harms, Nathan, Judy Shearer, James Cronin, and John Gaskin. Geographic and genetic variation in susceptibility of Butomus umbellatus to foliar fungal pathogens. Engineer Research and Development Center (U.S.), 2021. http://dx.doi.org/10.21079/11681/41662.

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Large-scale patterns of plant invasions may reflect regional heterogeneity in biotic and abiotic factors and genetic variation within and between invading populations. Having information on how effects of biotic resistance vary spatially can be especially important when implementing biological control because introduced agents may have different Impacts through interactions with host-plant genotype, local environment, or other novel enemies. We conducted a series of field surveys and laboratory studies to determine whether there was evidence of biotic resistance, as foliar fungal pathogens, in
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Colwell, F. S., R. Smith, J. K. Fredrickson, A. L. Reysenbach, J. P. Mckinley, and T. C. Onstott. Control of biologically Active Degradation Zones By Vertical Heterogeneity : Applications In Fractured Media. Office of Scientific and Technical Information (OSTI), 2001. http://dx.doi.org/10.2172/828363.

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Colwell, F. S., R. W. Smith, J. McKinley, J. Fredrickson, T. C. Onstott, and A. L. Reysenbach. Control of biologically active degradation zones by vertical heterogeneity: Applications in fractured media. 1997 annual progress report. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/13701.

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Colwell, F. S., R. Smith, J. P. McKinley, J. K. Fredrickson, T. C. Onstott, and A. L. Reysenbach. Control of biologically active degradation zones by vertical heterogeneity: Applications in fractured media. 1998 annual progress report. Office of Scientific and Technical Information (OSTI), 1998. http://dx.doi.org/10.2172/13702.

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