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Dissertations / Theses on the topic 'Biological modelling'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Lemon, A. P. "Modelling the biological membrane." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760688.

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2

Lumley, James Andrew. "Molecular modelling of biological activity." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393752.

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3

Luo, Yang. "Stochastic modelling in biological systems." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610145.

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4

Billing, Alison Emslie. "Modelling techniques for biological systems." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/21917.

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The objective of this investigation has been to develop and evaluate techniques which are appropriate to the modelling and simulation of biological reaction system behaviour. The model used as the basis for analysis of modelling and simulation techniques is a reduced version of the biological model proposed by the IAWPRC Task Group for mathematical modell ing in wastewater treatment design. This limited model has the advantage of being easily manageable in terms of analysis and presentation of the simulation techniQues whilst at the same time incorporating a range of features encountered with
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5

Cotton-Barratt, Rebecca. "Modelling biological form in evolution." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/70973/.

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How are processes working at the individual level, the species level and the macro-ecological level connected? This thesis explores the theoretical and structural constraints on biological evolution. It does this by developing an evolutionary program to model biological form. This development was necessary as the existing models of evolution are poorly suited to modelling morphological constraint. The model of biological form developed in this thesis uses graphs to abstractly represent organisms and the relationships of their internal structure. We show that by increasing the number of degrees
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6

Djordjilovic, Vera. "Graphical modelling of biological pathways." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424702.

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Biological pathways underlie the basic functions of a living cell. They are complex diagrams featuring genes, proteins and other small molecules, showing how they work together to achieve a particular biological effect. From a technical point of view, they are networks represented through a graph where genes and their connections are, respectively, nodes and edges of a graph. The main research objective of this thesis is to develop a framework for simulating effects of gene silencing. To this end, we propose a three step approach. First, we refine the structure of a pathway via our C
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7

Hodgkinson, Arran. "Mathematical Methods for Modelling Biological Heterogeneity." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS119.

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Les processus biologiques sont des phénomènes complexes, multi-échelles, présentant une hétérogénéité importante à travers l’espace, la structure et la fonction. De plus, ils impliquent des événements fortement corrélés et présentent des boucles de rétroaction à travers les échelles. Dans cette thèse, nous utilisons des représentations spatio-structuro-temporelles en grande dimension pour étudier l'hétérogénéité biologique à travers l'espace, la fonction biologique et le temps, et appliquons cette méthode à divers problèmes importants en biologie et en clinique.Nous commençons par introduire u
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8

Sharma, A. "Modelling biological systems: a fractal approach." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1991. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3009.

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9

Fear, Elise Carolyn. "Modelling biological cells exposed to electric fields." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32685.pdf.

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10

Liu, Dianbo. "Modelling biological networks : topology, dynamics and generation." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/8ab98533-d17f-4ea5-adb7-62b23d1e42bc.

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11

Lumbers, Jeremy. "Rotating biological contactors : mechanisms, modelling and design." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47161.

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12

Romanel, Alessandro. "Dynamic Biological Modelling: a language-based approach." Doctoral thesis, Università degli studi di Trento, 2010. https://hdl.handle.net/11572/368272.

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Systems biology investigates the interactions and relationships among the components of biological systems to understand how they globally work. The metaphor “cells as computations†, introduced by Regev and Shapiro, opened the realm of biological modelling to concurrent languages. Their peculiar characteristics led to the development of many different bio-inspired languages that allow to abstract and study specific aspects of biological systems. In this thesis we present a language based on the process calculi paradigm and specifically designed to account for the complexity of signalling n
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13

Romanel, Alessandro. "Dynamic Biological Modelling: a language-based approach." Doctoral thesis, University of Trento, 2010. http://eprints-phd.biblio.unitn.it/282/1/PhD-Thesis.pdf.

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Systems biology investigates the interactions and relationships among the components of biological systems to understand how they globally work. The metaphor “cells as computations”, introduced by Regev and Shapiro, opened the realm of biological modelling to concurrent languages. Their peculiar characteristics led to the development of many different bio-inspired languages that allow to abstract and study specific aspects of biological systems. In this thesis we present a language based on the process calculi paradigm and specifically designed to account for the complexity of signalling netwo
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14

Palmisano, Alida. "Modelling and Inference Strategies for Biological Systems." Doctoral thesis, Università degli studi di Trento, 2010. https://hdl.handle.net/11572/368774.

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For many years, computers have played an important role in helping scientists to store, manipulate, and analyze data coming from many different disciplines. In recent years, however, new technological capabilities and new ways of thinking about the usefulness of computer science is extending the reach of computers from simple analysis of collected data to hypothesis generation. The aim of this work is to provide a contribution in the Computational Systems Biology field. The main purpose of this recent discipline is to enhance the intertwined relationship connecting Biology and Computer Science
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15

Palmisano, Alida. "Modelling and Inference Strategies for Biological Systems." Doctoral thesis, University of Trento, 2010. http://eprints-phd.biblio.unitn.it/433/1/PhDThesisAlida.pdf.

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For many years, computers have played an important role in helping scientists to store, manipulate, and analyze data coming from many different disciplines. In recent years, however, new technological capabilities and new ways of thinking about the usefulness of computer science is extending the reach of computers from simple analysis of collected data to hypothesis generation. The aim of this work is to provide a contribution in the Computational Systems Biology field. The main purpose of this recent discipline is to enhance the intertwined relationship connecting Biology and Computer Scienc
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16

Yeste, Lozano Jose. "Microphysiological systems for modelling and monitoring biological barriers." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664204.

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Los sistemas microfisiológicos (MPS) son modelos in vitro microfabricados que emulan las condiciones in vivo fisiológicamente relevantes, como la organización celular y las señales microambientales. Las microtecnologías han permitido el desarrollo de sofisticados MPS capaces de recapitular fielmente la fisiología a nivel de tejido y órgano. Los MPS son particularmente útiles para modelar barreras biológicas, es decir, epitelios y endotelios que separan la circulación sanguínea de los compartimentos tisulares. Su función de barrera es crucial para mantener la homeostasis en los órganos y
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17

Dreiwi, Hanan Ali. "Using transfer function analysis in modelling biological invasions." Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/3749.

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This thesis is made up of seven chapters and two appendices. Chapter 1 provides an introduction whilst Chapter 7 o ers a conclusion. In Chapter 2 we provide preliminaries on population projection models and robustness analysis. In Chapter 3 we introduce a stage-structured model in a context of biological invasions. Using a Transfer Function Approach, we provide a detailed analysis of the invasion model where the existence and local stability of all possible equilibria are characterised in terms of the underlying parameters of the model. In Chapter 4, a Lyapunov function approach is used to est
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18

Basse, Britta. "Case studies in mathematical modelling for biological conservation." Thesis, University of Canterbury. Mathematics & Statistics, 1999. http://hdl.handle.net/10092/4804.

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The use of mathematical modelling as a tool for investigating selected topics in conservation biology is the focus of this thesis. A continuous system of partial and ordinary differential equations model the age structured population dynamics of a cohort of endemic, threatened New Zealand North Island brown kiwi, Apteryx mantelli. Critical predation and recruitment rates of immature birds are estimated. Stoats, Mustela erminea, are the main predator of immature kiwi. A refinement to the model allows the calculation of acceptable stoat densities. In order to reduce stoats to this critical densi
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19

Bernardini, Francesco. "Membrane systems for molecular computing and biological modelling." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425607.

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20

Thompson-Walsh, Christopher David. "Semantics and extension of a biological modelling language." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648266.

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21

Sorokina, Oxana. "Understanding biological timing by modelling simple circadian clocks." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/14456.

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22

Pinto, Mark Alexander. "Modelling of biological systems using multidimensional population balances." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/8502.

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Biological systems are intrinsically heterogeneous and, consequently, their mathematical descriptions should account for this heterogeneity as it often influences the dynamic behaviour of the individual cells. For example, in the cell cycle dependent production ofproteins, it is necessary to account for the distribution of the individual cells with respect to their position in the cell cycle as this has a strong influence on protein production. A second notable example is the formation of cancerous cells. In this case, the failure of regulatory mechanisms results in the transition of somatic c
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23

Pitcher, Jannette. "Modelling biological responses to environmental variables in wetlands." Thesis, Pitcher, Jannette (1999) Modelling biological responses to environmental variables in wetlands. PhD thesis, Murdoch University, 1999. https://researchrepository.murdoch.edu.au/id/eprint/42298/.

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Eutrophication and hydrologic changes resulting from increased agricultural and industrial activities have contributed to the degradation and loss of wetlands worldwide. The need to understand the response of wetland components to changing environmental conditions and to assess and predict ecological consequences of these changes has therefore intensified. Ecological models are proving to be valuable tools in managing these threatened ecosystems. A dynamic, spatially-explicit simulation model was developed to study the effects of different environmental conditions on the dynamics of wetland
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24

Hall, Cameron Luke. "Modelling of some biological materials using continuum mechanics." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/37244/1/Cameron_Hall_Thesis.pdf.

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Continuum mechanics provides a mathematical framework for modelling the physical stresses experienced by a material. Recent studies show that physical stresses play an important role in a wide variety of biological processes, including dermal wound healing, soft tissue growth and morphogenesis. Thus, continuum mechanics is a useful mathematical tool for modelling a range of biological phenomena. Unfortunately, classical continuum mechanics is of limited use in biomechanical problems. As cells refashion the �bres that make up a soft tissue, they sometimes alter the tissue's fundamental mechanic
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25

Ellery, Adam J. "Modelling transport through biological environments that contain obstacles." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/106798/1/Adam_Ellery_Thesis.pdf.

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Transport through biological environments that are densely crowded with obstacles is often classified as anomalous, rather than Fickian diffusion. Researchers often describe these transport processes using either a random walk model or a fractional order differential equation model. To explore these ideas, we simulate transport through a crowded environment that is populated by impenetrable immobile obstacles. Our work suggests that it may be inappropriate to model transport through a crowded environment using these standard approaches. We develop a new analytical method for modelling the t
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26

De, Haast James Andrew. "Modelling South African cold-water coral habitats." Master's thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31361.

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Cold-water corals are found globally but little is known about energy flows associated with these habitats. The degree to which the benthic ecosystems containing cold-water corals are linked to the overlying pelagic ecosystems is also poorly understood. Observational studies have indicated that fish abundance is greater in the waters surrounding coldwater coral reefs compared to nearby waters over barren seafloor, implying enhanced productivity in the cold-water coral ecosystems. Support for this hypothesis is tested in this study using a customised Ecopath with Ecosim model. The model is appl
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27

Myerscough, Mary Ruth. "A chemotactic model of biological pattern formation." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329983.

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28

Lee, Jae-Young. "A coupled physical-biological model for the Clyde Sea." Thesis, Edinburgh Napier University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247319.

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29

Bown, James Louis. "Issues of scale in individual-based models : applications in fungal and plant community dynamics." Thesis, Abertay University, 2000. https://rke.abertay.ac.uk/en/studentTheses/87bed9b3-454c-48ac-bbf6-ca6058179af8.

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The central question addressed in this thesis is whether descriptions of the dynamics of ecological systems at one scale may be effectively used as descriptions of the dynamics of ecological systems at larger scales. This question is addressed in the context of the dynamics of fungal communities. A simple experimental system and complementary theoretical approach, in the form of an individual-based (cellular automaton) model, is presented. Experimental results derived from small-scale systems are used to quantify parameters of the model; results from large-scale experimental systems serve to t
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30

Iyaniwura, Sarafa Adewale. "Mathematical modelling of partially absorbing boundaries in biological systems." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58907.

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This project presents a mathematical framework for identifying partially permeable biological boundaries, and estimating the rate of absorption of diffusing objects at such a boundary based on limited experimental data. We used partial differential equations (PDEs) to derive probability distribution functions for finding a particle performing Brownian motion in a region. These distribution functions can be fit to data to infer the existence of a boundary. We also used the probability distribution functions together with maximum likelihood estimation to estimate the rate of absorption of object
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31

Liao, Shuohao. "High-dimensional problems in stochastic modelling of biological processes." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2d710a16-e790-47eb-8670-a4dcdd86f143.

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Stochastic modelling of gene regulatory networks provides an indispensable tool for understanding how random events at the molecular level influence cellular functions. A common challenge of stochastic models is to calibrate a large number of model parameters against the experimental data. Another difficulty is to study how the behaviour of a stochastic model depends on its parameters, i.e. whether a change in model parameters can lead to a significant qualitative change in model behaviour (bifurcation). This thesis addresses such computational challenges by a tensor-structured computational f
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32

Grosfils, Aline. "First principles and black box modelling of biological systems." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210677.

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Living cells and their components play a key role within biotechnology industry. Cell cultures and their products of interest are used for the design of vaccines as well as in the agro-alimentary field. In order to ensure optimal working of such bioprocesses, the understanding of the complex mechanisms which rule them is fundamental. Mathematical models may be helpful to grasp the biological phenomena which intervene in a bioprocess. Moreover, they allow prediction of system behaviour and are frequently used within engineering tools to ensure, for instance, product quality and reproducibility.
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33

Lamb, Angharad. "Mathematical Modelling of the Biological Stress Response to Chronium." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517846.

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34

Turner, Stephen. "Mathematical modelling of cancer invasion and biological cell movement." Thesis, Heriot-Watt University, 2002. http://hdl.handle.net/10399/438.

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35

Walker, Gillian Claire. "Modelling the propagation of terahertz radiation in biological tissue." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406881.

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36

Lones, Michael Adam. "Enzyme genetic programming : modelling biological evolvability in genetic programming." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399653.

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37

Lewis, Miranda Claire. "Mathematical modelling of the growth of soft biological tissues." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436982.

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38

Chung, Andy Heung Wing. "Novel mathematical and computational approaches for modelling biological systems." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/60405/.

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This work presents the development, analysis and subsequent simulations of mathematical models aimed at providing a basis for modelling atherosclerosis. This cardiovascular disease is characterized by the growth of plaque in artery walls, forming lesions that protrude into the lumen. The rupture of these lesions contributes greatly to the number of cases of stroke and myocardial infarction. These are two of the main causes of death in the UK. Any work to understand the processes by which the disease initiates and progresses has the ultimate aim of limiting the disease through either its preven
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39

Sweeney, Paul William. "Realistic numerical image-based modelling of biological tissue substrates." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10049410/.

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The development of preclinical tools to study fluid transport within biological tissue is critical to understanding not only the progression of disease, but the role of the microenvironment in healthy tissue. The limited availability of experimental data across all length scales provides scope for the development of mathematical models to simulate fluid transport throughout the microvasculature and surrounding tissue. Here, the novel REANIMATE (REAlistic Numerical Image-based Modelling of biologicAl Tissue substratEs) platform is developed which, guided by both ex vivo and in vivo imaging data
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40

Degasperi, Andrea. "Multi-scale modelling of biological systems in process algebra." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2946/.

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There is a growing interest in combining different levels of detail of biological phenomena into unique multi-scale models that represent both biochemical details and higher order structures such as cells, tissues or organs. The state of the art of multi-scale models presents a variety of approaches often tailored around specific problems and composed of a combination of mathematical techniques. As a result, these models are difficult to build, compose, compare and analyse. In this thesis we identify process algebra as an ideal formalism to multi-scale modelling of biological systems. Building
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41

Jankovic, Masha. "Modelling biological invasions : population cycles, waves and time delays." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31392.

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Biological invasions are rapidly gaining importance due to the ever-increasing number of introduced species. Alongside the plenitude of empirical data on invasive species there exists an equally broad range of mathematical models that might be of use in understanding biological invasions. This thesis aims to address several issues related to modelling invasive species and provide insight into their dynamics. Part I (Chapter 2) documents a case study of the gypsy moth, Lymantria dispar, invasion in the US. We propose an alternative hypothesis to explain the patchiness of gypsy moth spread entai
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42

Montagud, Aquino Arnau. "Modelling and analysis of biological systems to obtain biofuels." Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/17319.

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Esta tesis se centra en la construcción y usos de los modelos metabólicos a escala genómica para obtener biocombustibles de manera eficiente, como etanol e hidrógeno. Como organismo objetivo, se ha elegido a la cianobacteria Synechocystis sp. PCC6803. Este organismo ha sido estudiado como una potencial plataforma de producción alimentada por fotones, dada su capacidad de crecer solamente a partir de dióxido de carbono y fotones. Esta tesis versa acerca de los métodos para modelar, analizar, estimar y predecir el comportamiento del metabolismo de las células. La principal meta es extraer conoci
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43

Rocca, Alexandre. "Formal methods for modelling and validation of biological models." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAM028/document.

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L’objectif de cette thèse est la modélisation et l’étude de systèmes biologiques par l’intermédiaire de méthodes formelles. Les systèmes biologiques démontrent des comportements continus mais sont aussi susceptibles de montrer des changements abrupts dans leur dynamiques. Les équations différentielles ordinaires, ainsi que les systèmes dynamiques hybrides, sont deux formalismes mathématiques utilisés pour modéliser clairement de tels comportements. Un point critique de la modélisation de systèmes biologiques est la recherche des valeurs des paramètres du modèle afin de reproduire de manière pr
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44

Kumar, Vijay. "Modelling the physico-biological processes of eastern Arabian sea." Thesis, IIT Delhi, 2016. http://localhost:8080/xmlui/handle/12345678/7093.

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45

Tsafnat, Guy Computer Science &amp Engineering Faculty of Engineering UNSW. "Abstraction and representation of fields and their applications in biomedical modelling." Awarded by:University of New South Wales. School of Computer Science and Engineering, 2006. http://handle.unsw.edu.au/1959.4/24207.

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Computer models are used extensively to investigate biological systems. Many of these systems can be described in terms of fields???spatially- and temporally- varying scalar, vector and tensor properties defined over domains. For example, the spatial variation of muscle fibers is a vector field, the spatial and temporal variation in temperature of an organ is a scalar field, and the distribution of stress across muscle tissue is a tensor field. In this thesis I present my research on how to represent fields in a format that allows researchers to store and distribute them independently of model
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46

Chan, David Chung Chan. "Design, synthesis and biological evaluation of novel antifolates against Pneumocystis carinii." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250580.

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47

Raju, Rajesh Kumar. "Computational Modelling of Noncovalent Interactions in Chemical and Biological Recognition." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508602.

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48

Fenwick, John David. "Biological modelling of pelvic radiotherapy : potential gains from conformal techniques." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322314.

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49

Key, H. "The modelling of light attenuation and transmission in biological tissues." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238177.

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50

Ortiz, guzman John Erick. "Fast boundary element formulations for electromagnetic modelling in biological tissues." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2017. http://www.theses.fr/2017IMTA0051/document.

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Cette thèse présente plusieurs nouvelles techniques pour la convergence rapide des solutions aux éléments de frontière de problèmes électromagnétiques. Une attention spéciale a été dédiée aux formulations pertinentes pour les solutions aux problèmes électromagnétiques dans les tissus biologiques à haute et basse fréquence. Pour les basses fréquences, de nouveaux schémas pour préconditionner et accélérer le problème direct de l'électroencéphalographie sont présentés dans cette thèse. La stratégie de régularisation repose sur une nouvelle formule de Calderon, obtenue dans cette thèse, alors que
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