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Dissertations / Theses on the topic 'Biologically active compounds'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Omar, Muhammad Nor bin. "Synthesis of biologically active compounds." Thesis, Liverpool John Moores University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343121.

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2

Burnell, Erica Sinead. "Synthesis of biologically active compounds." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-biologically-active-compounds(a009591b-d439-4ff7-9e6f-36199a33e7c8).html.

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Part 1 describes the synthesis of (2S,3S,4R,5R)-5-(6-(((7-bromo-2-(dimethylamino)-4-((3-methylisoxazol-5-yl)methoxy)benzo[d]oxazol-5-yl)methyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide, a selective A3 adenosine receptor agonist, and one of a number of adenosine analogues designed by Muscagen Ltd. with the purpose of treating cardiac ischaemia. The target compound was derived from a condensation of the known modified adenosine, (3aS,4S,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-N,2,2-trimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide with 5-(aminomethyl)-7-bromo-N,
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3

Salunkhe, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3270.

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4

Dhokte, U. P. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3299.

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5

Naik, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3274.

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6

Khobragade, D. A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2529.

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7

Kumar, A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1989. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3326.

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8

Bhonsle, J. B. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1992. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3034.

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9

Vidyasagar, V. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3228.

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10

Reddy, P. S. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3232.

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11

Nachman, J. "Structural studies on biologically active compounds." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356662.

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12

Birch, D. J. "The synthesis of biologically active compounds." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233498.

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13

Wilson, Jennifer M. "Synthesis of biologically active heterocyclic compounds." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/45/.

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More than 11 million people worldwide are diagnosed with cancer every year. New cancer drugs are required that are more effective and selective. Nitrogen mustard alkylating agents crosslink DNA inhibiting transcription and replication. Use of the mustard pharmacophore as part of a macrocycle allows metal complexation and produces a prodrug. Hypoxic tumour cells have increased concentrations of reductase enzymes which could lead to reduction of the complex in situ and release of a cytotoxic drug. Human African Trypanosomiasis is commonly known as Sleeping Sickness and affects over 36 countries
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14

Whapham, Catherine. "Biologically-active compounds in seaweed extracts." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310473.

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15

Upadhye, B. K. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2974.

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16

Menon, R. B. "Synthetic studies on biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2970.

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17

Gupta, M. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3254.

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18

Kamalam, M. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3221.

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19

Joshi, G. S. "Synthetic studies in biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3288.

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20

Kher, S. M. "Synthetic studies in biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1990. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3000.

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21

Garyali, K. "Synthesis of some biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3240.

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22

Sivadasan, L. "Synthesis of some biologically active compounds." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2228.

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23

Bhosale, S. S. "Synthetic studies in biologically active organic compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3217.

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24

Randad, R. S. "Synthetic transformations leading to biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3223.

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25

Jadhav, C. B. "Study of biologically active compounds by hplc." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1991. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1995.

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26

Mutlu, Esra. "Synthetic and Analytical Studies of Biologically Active Compounds." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489838.

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first part of the project aimed to access tetralone intermediates required for the benzo[f]quinazoline inhibitors of thymidylate synthase. The project focussed sibility ofusing the intramolecular Buchner reaction to devise a short route from ailable starting materials. Hence, this route to the tetralones was via Rh(II) decomposition of precursor diazoketones. The synthesis of benzoquinazolines bus routes was relatively long, problematical and not cost effective. It was found of diazoketones with Rh(II) catalysis lead to the desired tetralones in e yields (Scheme 1). 1. Synthesis of tetralones
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27

Bandini, Elisa <1966&gt. "Biologically Active Compounds Via 2-Aza-1,3-Dienes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/476/1/PhD_Thesis_BANDINI_ELISA.pdf.

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28

Bandini, Elisa <1966&gt. "Biologically Active Compounds Via 2-Aza-1,3-Dienes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/476/.

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29

Deo, M. G. "Studies in biologically active compounds using chromatography techniques." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3268.

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30

Gharpure, M. M. "Synthesis of biologically active compounds and their analogues." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3307.

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31

Patil, V. J. "Synthesis of some biologically active compounds from carbohydrates." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3239.

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32

Askew, Stuart Clive. "Some studies of biologically active S-nitrosothiols." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/15189.

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S-nitrosothiols are effective NO-donating drugs which can elicit vasodilation of vascular tissue and disaggregate or inhibit the aggregation of platelets in blood. The chemistries of two S-nitrosothiols, S-nitroso-N-acetyl-DL-penicillamine (SNAP) and S-nitrosoglutathione (GSNO) have been investigated in an attempt to identify the chemical and physiological mechanisms which underlie their biological actions as vasodilators and modulators of platelet behaviour. Although SNAP and GSNO have been found to be susceptible to decomposition by similar chemical mechanisms, such as by thermal and photoch
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33

Begum, Lovely. "The synthesis of fluorinated analogues of biologically active compounds." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343327.

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34

MIERI, M. DE. "CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/148883.

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Biologically active compounds are usually polyfunctional molecules bearing one or more stereocenters. Enzyme catalyzed transformations are well suitable for their preparation since they act in a very mild and selective manner. The study of three selected biocatalyzed transformations has been the aim of my PhD researches. The first project, regards the development of an advantageous and mild method to selectively transform the 24-hydroxyl function of ascomycin, a 23-membered macrolactam, bearing two secondary alcoholic moieties bounded at position 24 and 32 of its macrocycle. This selective pro
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35

N, Dhawane A. "Synthetic studies towards camptothecin and other biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2010. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3731.

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36

Bhamare, N. K. "New methods for the synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3293.

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37

Witherington, Jason. "Novel synthetic methods enabling the construction of biologically active compounds." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386942.

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38

Wickens, Kristen M. "A search for biologically active compounds in Acacia (Mimosaceae) species." Thesis, Curtin University, 2003. http://hdl.handle.net/20.500.11937/1262.

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Indigenous Australians were also known to use plants for medicinal purposes. For thousands of years, Indigenous Australians have used native plants as a source of medicinal agents. Some tribes living in Central Australia still, to this day, prefer to use traditional medicines in favour of the more common and readily available western medicines. A number of plant species endemic to Australia are listed in various Aboriginal pharmacopoeias, with approximately one-third of those species belonging to two genera, Acacia and Eremophila. Of the 1100 recognised species of Acacia, approximately 900 occ
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39

Wickens, Kristen M. "A search for biologically active compounds in Acacia (Mimosaceae) species." Curtin University of Technology, Department of Environmental Biology, 2003. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=15212.

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Indigenous Australians were also known to use plants for medicinal purposes. For thousands of years, Indigenous Australians have used native plants as a source of medicinal agents. Some tribes living in Central Australia still, to this day, prefer to use traditional medicines in favour of the more common and readily available western medicines. A number of plant species endemic to Australia are listed in various Aboriginal pharmacopoeias, with approximately one-third of those species belonging to two genera, Acacia and Eremophila. Of the 1100 recognised species of Acacia, approximately 900 occ
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40

Mosconi, Elisa <1981&gt. "Stereoselective synthesis of heterocycles as intermediates of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3432/1/Mosconi_Elisa_tesi.pdf.

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The aim of this thesis was to investigate the synthesis of enantiomerically enriched heterocycles and dehydro-β-amino acid derivatives which can be used as scaffolds or intermediates of biologically active compounds, in particular as novel αvβ3 and α5β1 integrin ligands. The starting materials of all the compounds here synthesized are alkylideneacetoacetates. Alkylidene derivates are very usefull compounds, they are usually used as unsaturated electrophiles and they have the advantage of introducing different kind of functionality that may be further elaborated. In chapter 1, regio- and stere
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41

Mosconi, Elisa <1981&gt. "Stereoselective synthesis of heterocycles as intermediates of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3432/.

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The aim of this thesis was to investigate the synthesis of enantiomerically enriched heterocycles and dehydro-β-amino acid derivatives which can be used as scaffolds or intermediates of biologically active compounds, in particular as novel αvβ3 and α5β1 integrin ligands. The starting materials of all the compounds here synthesized are alkylideneacetoacetates. Alkylidene derivates are very usefull compounds, they are usually used as unsaturated electrophiles and they have the advantage of introducing different kind of functionality that may be further elaborated. In chapter 1, regio- and stere
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42

Reddy, P. S. "Synthesis of some biologically active compounds and some natural products." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3261.

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43

Esmati, Nasim. "Synthesis of Biologically Active Compounds via Multicomponent Reactions and Evaluation of Their Biological Activities." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525897360405194.

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44

D’Aurizio, Antonio <1978&gt. "Microwave-Mediated Hetero Diels-Alder reaction: Synthesis of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1641/1/D%27Aurizio_Antonio_Tesi.pdf.

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Heterocyclic compounds represent almost two-thirds of all the known organic compounds: they are widely distributed in nature and play a key role in a huge number of biologically important molecules including some of the most significant for human beings. A powerful tool for the synthesis of such compounds is the hetero Diels-Alder reaction (HDA), that involve a [4+2] cycloaddition reaction between heterodienes and suitable dienophiles. Among heterodienes to be used in such six-membered heterocyclic construction strategy, 3-trialkylsilyloxy-2-aza-1,3-dienes (Fig 1) has been demonstrated parti
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45

D’Aurizio, Antonio <1978&gt. "Microwave-Mediated Hetero Diels-Alder reaction: Synthesis of biologically active compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1641/.

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Heterocyclic compounds represent almost two-thirds of all the known organic compounds: they are widely distributed in nature and play a key role in a huge number of biologically important molecules including some of the most significant for human beings. A powerful tool for the synthesis of such compounds is the hetero Diels-Alder reaction (HDA), that involve a [4+2] cycloaddition reaction between heterodienes and suitable dienophiles. Among heterodienes to be used in such six-membered heterocyclic construction strategy, 3-trialkylsilyloxy-2-aza-1,3-dienes (Fig 1) has been demonstrated parti
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46

Pathak, A. B. "Synthetic studies towards camptothecin, its analogues and other biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2637.

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47

Sivappa, R. "Total synthesis of camptothecin and its analogues and biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2002. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2858.

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48

Jadhav, G. S. "Studies in the synthesis of new chromophoric and biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Poona, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/6132.

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49

彭向榮 and Heung-wing Pang. "Studies toward the total synthesis of biologically active cyclodepsipeptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31227752.

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50

Zembower, David Ewing. "The synthesis and structure-activity relationships of biologically active anthraquinones." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/26250.

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