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1

Hart, John P., and Malcolm R. Smyth. "Electroanalysis of biologically important compounds." Analytica Chimica Acta 244 (1991): 295–96. http://dx.doi.org/10.1016/s0003-2670(00)82517-9.

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2

Covington, A. K. "Electroanalysis of biologically important compounds." Electrochimica Acta 36, no. 14 (1991): 2196. http://dx.doi.org/10.1016/0013-4686(91)85234-x.

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3

Bartlett, P. N. "Electroanalysis of biologically important compounds." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 310, no. 1-2 (1991): 454. http://dx.doi.org/10.1016/0022-0728(91)85283-u.

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4

Perrett, D. "Electroanalysis of biologically important compounds." Chromatographia 38, no. 11-12 (1994): 792. http://dx.doi.org/10.1007/bf02269638.

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5

Kissinger, P. T. "Electroanalysis of biologically important compounds." Journal of Chromatography B: Biomedical Sciences and Applications 568, no. 1 (1991): 270. http://dx.doi.org/10.1016/0378-4347(91)80364-i.

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6

Mugesh, Govindasamy, Wolf-Walther du Mont, and Helmut Sies. "Chemistry of Biologically Important Synthetic Organoselenium Compounds." Chemical Reviews 101, no. 7 (2001): 2125–80. http://dx.doi.org/10.1021/cr000426w.

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7

Deshmukh, A. R., B. Bhawal, D. Krishnaswamy, Vidyesh Govande, Bidhan Shinkre, and A. Jayanthi. "Azetidin-2-ones, Synthon for Biologically Important Compounds †." Current Medicinal Chemistry 11, no. 14 (2004): 1889–920. http://dx.doi.org/10.2174/0929867043364874.

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8

Karaaslan, Cigdem, and Sibel Suzen. "Electrochemical Behavior of Biologically Important Indole Derivatives." International Journal of Electrochemistry 2011 (2011): 1–10. http://dx.doi.org/10.4061/2011/154804.

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Voltammetric techniques are most suitable to investigate the redox properties of a new drug. Use of electrochemistry is an important approach in drug discovery and research as well as quality control, drug stability, and determination of physiological activity. The indole nucleus is an essential element of a number of natural and synthetic products with significant biological activity. Indole derivatives are the well-known electroactive compounds that are readily oxidized at carbon-based electrodes, and thus analytical procedures, such as electrochemical detection and voltammetry, have been de
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9

Moriarty, Robert M., Yi-Yin Ku, and Udai S. Gill. "Novel cyclopentadienyl ruthenium(II) complexes of biologically important compounds." Journal of the Chemical Society, Chemical Communications, no. 24 (1987): 1837. http://dx.doi.org/10.1039/c39870001837.

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10

Honda, Y., R. Navarro-Gonzalez, and C. Ponnamperuma. "Chemical yields of biologically important compounds from electric discharges." International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 33, no. 3 (1989): 287. http://dx.doi.org/10.1016/1359-0197(89)90202-6.

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11

Mugesh, Govindasamy, Wolf-Walther du Mont, and Helmut Sies. "ChemInform Abstract: Chemistry of Biologically Important Synthetic Organoselenium Compounds." ChemInform 32, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.200139275.

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12

Rajeev, Jain, and Bhadauria Akhilesh. "Synthesis ·of some biologically important hydrazono and azomethine compounds." Journal of Indian Chemical Society Vol. 84, Feb 2007 (2007): 197–99. https://doi.org/10.5281/zenodo.5814795.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, Madhya Pradesh, India <em>E-mail</em> : gwlsosmica@sancharnet. in <em>Fax</em>: 91-751-346209 <em>Manuscript received 16 February 2004, revised 12 October 2006, accepted 12 December 2006</em> 2-(4&#39;-Sulphonamoylphenyl)hydrazonoindane-1,3-diones (la-e) were synthesized by coupling indanc-1,3-dionc with diazotized sulphonamides. 3-(4&#39; -Sulphonamoylphenyl) azomethineindoles (2a-e) and 3- aminobenzothiazolyl) azomethineindole (3) were synthesised by refluxing indole-3-carboxaldehyde with sulfonamide derivatives and 3- amino
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13

Gupta, Khushbu, and Tejpal Singh Chundawat. "Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds." Asian Journal of Chemistry 31, no. 12 (2019): 2698–706. http://dx.doi.org/10.14233/ajchem.2019.22205.

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Green route of biogenic synthesis of heterocyclic compounds via microbes (bacteria, fungi, virus, yeast, algae, etc.) has the potential to deliver clean manufacturing technology. The application of biocatalysts for the synthesis of novel compounds has attracted increasing attention over the past few years and consequently, high demands have been placed on the identification of new biocatalysts for organic synthesis. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies. The
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14

Yu, Bin, Hui Xing, De-Quan Yu, and Hong-Min Liu. "Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update." Beilstein Journal of Organic Chemistry 12 (May 18, 2016): 1000–1039. http://dx.doi.org/10.3762/bjoc.12.98.

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Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these compounds, enantioenriched 3-hydroxyoxindole scaffolds also exist in natural products and have proven to possess promising biological activities. A large number of catalytic asymmetric strategies toward the construction of 3-hydroxyoxindoles based on transition metal catalysis and organocatalysis have been reported in the last decades. Additio
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15

Berger, Rainer. "The Synthesis of Biologically Important Organic Compounds from Abiologic Systems." Bulletin des Sociétés Chimiques Belges 72, no. 3-4 (2010): 255–63. http://dx.doi.org/10.1002/bscb.19630720309.

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16

Sinko, J., J. Rajchard, Z. Balounova, and L. Fikotova. " Biologically active substances from water invertebrates: a review." Veterinární Medicína 57, No. 4 (2012): 177–84. http://dx.doi.org/10.17221/5914-vetmed.

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Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. The real sources of compounds with these antipredatory effects are probably not marine invertebrates themselves, but microscopic symbionts or food which they feed on. Bryostatins from bryozoan species Bugula neritina are produced by a bacterial symbiont called Candidatus Endobugula sertula. They have
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17

Škvareninová, Katarína, Štefan Baláž, Ernest Šturdík, Miroslav Veverka, Jana Adamcová, and Jana Olexová. "Biologically Important Physicochemical Properties of Some Cephalosporins." Collection of Czechoslovak Chemical Communications 57, no. 8 (1992): 1739–46. http://dx.doi.org/10.1135/cccc19921739.

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In the series of cephalosporin derivatives, consisting of eight 7-(R1-CH2-CO-NH)cephalosporanic acids and of seven analogical compounds with 3-acetoxymethyl replaced by 3-CH3, physicochemical properties, which are expected to play a role in their antibacterial effects (the transport rate parameters and partition coefficients in the systems 1-octanol-water and 1-octanol-buffer, dissociation constants of the 4-carboxyl group, reactivity towards L-glutathione imitating the nucleophilic groups of the cell components and hydrolysis rate parameters), were determined. Linear dependences were observed
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18

Thakur, Abhinay, Rohit Sharma, Vivek Sheel Jaswal, Eugenie Nepovimova, Ashun Chaudhary, and Kamil Kuca. "Psoralen: A Biologically Important Coumarin with Emerging Applications." Mini-Reviews in Medicinal Chemistry 20, no. 18 (2020): 1838–45. http://dx.doi.org/10.2174/1389557520666200429101053.

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Coumarin belongs to a class of lactones that are fundamentally comprised of a benzene ring fused to an α-pyrone ring; these lactones are known as benzopyrones. Similarly, coumarin has a conjugated electron-rich framework and good charge-transport properties. Plants produce coumarin as a chemical response to protect themselves from predation. Coumarins are used in different products, such as cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks, and they play a relevant role in natural products and in organic and medicinal chemistry. In addition, as candi
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19

Baláž, Štefan, Ernest Šturdík, Regina Ujhelyová, et al. "Biologically Important Physicochemical Properties of Kojic Acid Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 3 (1993): 693–701. http://dx.doi.org/10.1135/cccc19930693.

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Physicochemical properties (hydrophobicity, acidity, metal complexing ability), which are expected to play a role in biological activity of kojic acid derivatives, were determined for 35 compounds. The structure-property relationship were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correlation factors according t
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20

Cheruiyot, Koech Samson, Michaela Plechatá, Wasu Pathom-aree, Zdenek Kamenik, and Amit Jaisi. "Strategies for Actinobacteria Isolation, Cultivation, and MetaboliteProduction that Are Biologically Important." ACS Omega 10, no. 16 (2025): 15810–7050. https://doi.org/10.1021/acsomega.5c01344.

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21

Elkhateeb, Waill A., Dina E. El-Ghwas, and Daba GM. "Mushrooms and Lichens the Factory of Important Secondary Metabolites: Review." Journal of Biomedical Research & Environmental Sciences 4, no. 6 (2023): 1072–82. http://dx.doi.org/10.37871/jbres1770.

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Mushrooms and lichens are plentiful source of nutritional and medicinal compounds. However, medicinal uses of the mushrooms and lichens still need to be worked out for their biological activities. Mushrooms and Lichens have reserved their position centuries ago as food and medicine. They are rich in nutrients and in biologically active compounds that belong to different chemical classes. Capabilities of different members of mushrooms and Lichens have encouraged researchers to investigate further applications of these macrofungi and lichens in fields of food and pharmaceutical industries and al
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22

Karan, Ram, Pooja Agarwal, Mukty Sinha, and Neelima Mahato. "Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry." ChemEngineering 5, no. 4 (2021): 73. http://dx.doi.org/10.3390/chemengineering5040073.

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This paper intended to explore and discover recent therapeutic agents in the area of medicinal chemistry for the treatment of various diseases. Heterocyclic compounds represent an important group of biologically active compounds. In the last few years, heterocyclic compounds having quinazoline moiety have drawn immense attention owing to their significant biological activities. A diverse range of molecules having quinazoline moiety are reported to show a broad range of medicinal activities like antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, antibacterial, antioxidant and o
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23

Roberts, Stanley M., M. Gabriella Santoro, and Eugene S. Sickle. "The emergence of the cyclopentenone prostaglandins as important, biologically active compounds." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (July 9, 2002): 1735–42. http://dx.doi.org/10.1039/b110043m.

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24

Parkash, Ram, Hari Om Gupta, and Jatinder Dutt. "Chronopotentiometric studies of certain biologically important compounds at tubular graphite electrode." Collection of Czechoslovak Chemical Communications 56, no. 9 (1991): 1833–37. http://dx.doi.org/10.1135/cccc19911833.

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The chronopotentiometric studies of certain phenothiazines in hydrodynamic systems at a solution flow-through tubular graphite electrode were carried out in sulfuric acid of different concentrations. A well-defined single wave (involving 2 electrons) in 0.1M H2SO4 and two waves (involving 1 electron each) in 2.0M H2SO4 were observed. Phenothiazines are oxidized trough the formation of a monocation radical by the elimination of one electron from the lone pair of N-atom. The monocation radical is stable in sulfuric acid of a moderate concentration and is unstable in neutral or less acidic soluti
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25

Winterbourn, Christine C., and Diana Metodiewa. "Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide." Free Radical Biology and Medicine 27, no. 3-4 (1999): 322–28. http://dx.doi.org/10.1016/s0891-5849(99)00051-9.

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26

Roberts, Stanley M., M. Gabriella Santoro, and Eugene S. Sickle. "The Emergence of the Cyclopentenone Prostaglandins as Important, Biologically Active Compounds." ChemInform 34, no. 1 (2003): no. http://dx.doi.org/10.1002/chin.200301235.

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27

Naicker, Tricia. "Special Issue: Advances in the Synthesis of Biologically Important Intermediates/Drugs." Applied Sciences 13, no. 4 (2023): 2390. http://dx.doi.org/10.3390/app13042390.

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28

Amadi, Ugochukwu B., Martin O. C. Ogwuegbu, Conrad K. Enenebeaku, and Gerald O. Onyedika. "A Review on Synthesis, Lanthanide Complexes and Biological Activites of Hydrazone Derivatives of Hydrazinecarbothioamides." International Research Journal of Pure and Applied Chemistry 24, no. 5 (2023): 54–63. http://dx.doi.org/10.9734/irjpac/2023/v24i5825.

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Hydrazinecarbothioamides are important intermediates with biological activities in organic chemistry synthesis, especially in the synthesis of biologically active heterocyclic scaffolds and compounds. The uniqueness in of synthesis and a wild range of pharmaceutical, medicinal biological potentials and properties, their preferred application as building brick in and the synthesis of heterocyclic and other important organic compounds and nonlinear optical (NLO) materials have made them attractive derivatives of thiosemicarbazides in the recent years. In this review, a detailed account in terms
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29

Siddharth, Saket, and Ravishankar V. Rai. "Actinomycetes as a Paramount Source of Biologically Important Enzyme Inhibitors – “A Boon to Mankind”." Current Bioactive Compounds 15, no. 1 (2019): 19–30. http://dx.doi.org/10.2174/1573407213666170116161747.

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Background:Bioactive compounds from microorganisms have been widely studied for several biological, therapeutic and pharmaceutical importances. Bacterial secondary metabolites have proven their worth as a prolific source of antibiotics, antifungal, antiviral, anticholesterol and immunosuppressant. The majority of inhibitors are secondary metabolites of varying chemical moieties produced by microorganisms among which actinomycetes are most important due to their tremendous diversity. Actinomycetes are most economically and commercially important prokaryotes known for their metabolic versatility
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30

Kochetkov, Konstantin A., Olga N. Gorunova, and Natalia A. Bystrova. "Biologically Oriented Hybrids of Indole and Hydantoin Derivatives." Molecules 28, no. 2 (2023): 602. http://dx.doi.org/10.3390/molecules28020602.

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Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct C–C bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought r
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31

Karpenko, Yu V., S. M. Kulish, and N. А. Al Halaf. "Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5-disubstituted 1,3,4-oxadiazoles (Part 2)." Current issues in pharmacy and medicine: science and practice 14, no. 3 (2021): 390–98. http://dx.doi.org/10.14739/2409-2932.2021.3.243664.

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Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,3,4-oxadiazoles have been of interest to chemists owing to their diverse therapeutic potential; the studies focus mainly on the principles of combinatorial chemistry with a broad spectrum of biological activity. In the continuation of the review article, the general literature sources that consider chemical heteryl derivatives of 2,5-disubstitute
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32

VJ, Dessy, S. R. Sivakumar, Mariat George, and Steffy Francis. "GC–MS analysis of bioactive compounds present in different extracts of rhizome of Curcuma aeruginosa Roxb." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 13–19. http://dx.doi.org/10.22270/jddt.v9i2-s.2589.

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To analyze and characterize the chemical composition of the different crude extracts from the rhizome of Curcuma aeruginosa Roxb a medicinal plant.The air-dried rhizomes were powdered and subjected to Soxhlet extraction using solvent n-hexane and Supercritical fluid extraction. Then, each of the extracts was further subjected to gas chromatography-mass spectrometry. Qualitative determination of the different biologically active compounds from crude extracts of C aeruginosa Roxb using gas chromatography–mass spectrometry revealed different types of high and low molecular weight chemical entitie
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33

N., M. Chavhan, V. Badadhe P., S. Bhagat S., S. Joshi R., G. Mandhane P., and H. Gill C. "Synthesis of some biologically important pyrazoles and pyrazoline derivatives." Journal of Indian Chemical Society Vol. 88, Mar 2011 (2011): 457–60. https://doi.org/10.5281/zenodo.5766093.

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Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, Maharashtra, India <em>E-mail</em> : chgill50@yahoo.com Radhabai Kale Mahila Mahavidyalaya, Ahmednagar-414 001, Maharashtra, India Manuscript received 01 June 2009, revised 09 July 2010, accepted 20 July 2010 1-(2-Hydroxyphenyl)ethanone (1) on treatment with 3-(benzofuran-2-yl)-1-phenyl-lH-p,-razole-4-carbaldehyde (2) gave corresponding chalcones (3). These chalcones on treatment with DMSO/I<sub>2</sub> and hydrazine hydrate gave 2-heteroaryl chromones (4) and pyrazolines (6). The chromones (4) on treatm
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34

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, and Divya Rama. "Synthetic applications of biologically important Mannich bases: An updated review." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (2023): 001–15. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0015.

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Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ion (OH- ), cyanide ion (CN-), ammonia and water, which involves the condensation of three components, viz., ammonia or a primary amine or a secondary amine or with amides, a non-enolizable aldehyde, usually formaldehyde and a compound containing an active hydrogen atom. These three compounds condense with the concomitant release of the water molecule to produce a new base known as a mannich base, in which the active
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35

Ibadullaуeva, G. S., A. A. Azembaev, and G. S. Nazarov. "QUALITATIVE AND QUANTITATIVE DETERMINATION OF FLAVONOIDS IN EXTRACT FROM PLANT RAW MATERIALS OF CAMEL TONE (ALHAGE PSEUDALHAGI)." Biosafety and Biotechnology, no. 16 (September 12, 2024): 48–60. http://dx.doi.org/10.58318/2957-5702-2023-16-48-60.

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This review analyzes the qualitative and quantitative content of biologically active substances in the raw material of camel thorn (Alhage pseudalhagi). During the study, the extract from the plant material Alhage pseudalhagi was obtained with the help of ultrasound. The method of determining the amount of flavonoids, antioxidants and other important biologically active compounds in plant raw materials with biological properties is considered. It has been established that the ultrasonic extraction method allows obtaining a large amount of flavonoids and extractive substances. The technology of
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36

Yang, Yan-Tao, Jun-Fang Zhu, Guochao Liao, Hai-Jiang Xu, and Bin Yu. "The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents." Current Medicinal Chemistry 25, no. 19 (2018): 2233–44. http://dx.doi.org/10.2174/0929867325666171129131311.

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Background: Antibiotic resistance is one of the biggest threats to global health today, leading to higher medical costs and increased mortality. Because of the emergence and rapid spread of new resistance mechanisms globally, a growing number of infections are becoming harder to treat as the antibiotics used to treat them become less effective. Therefore, the development of new effective antimicrobial agents is still urgently needed. In last decades, a large number of structurally novel spirooxindoles have been synthesized mainly based on the ylide intermediates generated in situ and further a
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37

Kurbanoglu, Sevinc, Mehmet Altay Unal, and Sibel A. Ozkan. "Recent developments on electrochemical flow injection in pharmaceuticals and biologically important compounds." Electrochimica Acta 287 (October 2018): 135–48. http://dx.doi.org/10.1016/j.electacta.2018.04.217.

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38

Yang, Yu-pei, Nusrat Hussain, Liu Zhang, et al. "Kadsura coccinea: A rich source of structurally diverse and biologically important compounds." Chinese Herbal Medicines 12, no. 3 (2020): 214–23. http://dx.doi.org/10.1016/j.chmed.2020.03.006.

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39

Tylko, Grzegorz, Wincenty M. Kilarski, and Marek Mikrut. "Indirect Measurement of Biologically Important Compounds by Means of X-Ray Microanalysis." Microchimica Acta 139, no. 1-4 (2002): 189–93. http://dx.doi.org/10.1007/s006040200060.

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40

Honda, Yasuhiro, Rafael Navarro-González, and Cyril Ponnamperuma. "A quantitative assay of biologically important compounds in simulated primitive earth experiments." Advances in Space Research 9, no. 6 (1989): 63–66. http://dx.doi.org/10.1016/0273-1177(89)90209-3.

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41

Raypa, Pratima, A. K. Verma, Salil Tewari, and Ashutosh Dubey. "Analysis of Medicinally Important Phytocompounds from Adina cordifolia Roots." International Journal of Current Microbiology and Applied Sciences 13, no. 6 (2024): 240–45. http://dx.doi.org/10.20546/ijcmas.2024.1306.025.

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The present study aimed to investigate the bioactive phytochemical constituents of Adina cordifolia through GC-MS analysis. To identify the pharmacologic important compounds present in Adina cordifolia roots, extracts were prepared using cold extraction method in different solvents of different polarity, namely chloroform, ethyl acetate, acetone and methanol. Gas chromatography-mass spectrometry (GC-MS) was performed to identify the phytocompounds present in the plant extracts using the National Institute of Standards and Technology (NIST) library. A wide range of fatty acids and plant compoun
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42

Salakhutdinov, Nariman F., Konstantin P. Volcho, and Olga I. Yarovaya. "Monoterpenes as a renewable source of biologically active compounds." Pure and Applied Chemistry 89, no. 8 (2017): 1105–17. http://dx.doi.org/10.1515/pac-2017-0109.

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AbstractMonoterpenes and their derivatives play an important role in the creation of new biologically active compounds including drugs. The review focuses on the data on various types of biological activity exhibited by monoterpenes and their derivatives, including analgesic, anti-inflammatory, anticonvulsant, antidepressant, anti-Alzheimer, anti-Parkinsonian, antiviral, and antibacterial (anti-tuberculosis) effects. Searching for novel potential drugs among monoterpene derivatives shows great promise for treating various pathologies. Special attention is paid to the effect of absolute configu
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43

Rajchard, J. "Sex pheromones in amphibians: a review ." Veterinární Medicína 50, No. 9 (2012): 385–89. http://dx.doi.org/10.17221/5637-vetmed.

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Amphibians are interesting animals, very often kept by aquarists and vivarists. Their ability of intraspecific chemical signalization belongs to very interesting biological features. The skin glands of anurans secrete various biologically active compounds. The pheromones are peptides consisting of various numbers of amino acid residues and their synthesis is regulated by hormones (e.g. prolactin and androgens). Similarly, the responsiveness of the vomeronasal epithelium to some of these compounds is enhanced by some hormonal substances (prolactin and oestrogen). Hypophyseal hormones, arginine
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44

Barbuceanu, Stefania-Felicia, and Octavian Tudorel Olaru. "Synthesis and Evaluation of Biologically Active Compounds from Heterocycles Class." Molecules 30, no. 2 (2025): 394. https://doi.org/10.3390/molecules30020394.

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45

Mithlesh, Pawan K. Pareek, Hemraj Chippa, Ravikant, and Krishan G. Ojha. "Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety." Collection of Czechoslovak Chemical Communications 75, no. 3 (2010): 275–87. http://dx.doi.org/10.1135/cccc2009051.

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2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.
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46

Panda, Siva S., Adel S. Girgis, Marian N. Aziz, and Mohamed S. Bekheit. "Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold." Molecules 28, no. 2 (2023): 618. http://dx.doi.org/10.3390/molecules28020618.

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Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.
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47

Ziarani, Ghodsi M., Fatemeh Mohajer, Razieh Moradi, and Parisa Mofatehnia. "The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds." Current Organic Synthesis 16, no. 7 (2019): 953–67. http://dx.doi.org/10.2174/1570179416666190925162215.

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Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I
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48

Hosny, Mona A., Wafaa A. Mokbe, and Emtithal A. El-Sawi. "Synthesis and Evaluation of Important Biologically Active Heterocyclic Compounds: Schiff Bases, Oxadiazole and Pyrazolyl Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 9, no. 2 (2013): 1892–99. http://dx.doi.org/10.24297/jac.v9i2.2341.

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In this work, we prepared an excellent yield of (2-oxo-2H-pyrano[3,2-h] quinolin-4-yl) acetic acid; compound (1) and from the reaction of it with hydrazine hydrate (100%) we obtain 2-(2-oxo-2H-pyrano [3,2-h] quinolin-4-yl) aceto hydrazide (2) which is the starting material for the synthesis of several series of new compounds: such as schiff’s bases (3a-e) and compound (4) in good yields, hydrazide derivatives like compound (5), derivatives of mercapto oxadiazole as compound (6) and derivatives of pyrazolyl as compound (7). All these compounds were found to possess high antimicrobial activity a
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49

Sultanova, R. M., N. S. Khusnutdinova, Yu G. Borisova, G. Z. Raskildina, and S. S. Zlotsky. "SYNTHESIS OF POLYSUBSTITUTED CYCLIC ACETALS AND THEIR BIOLOGICAL ACTIVITY." Izvestia Ufimskogo Nauchnogo Tsentra RAN, no. 2 (June 16, 2025): 114–25. https://doi.org/10.31040/2222-8349-2025-0-2-114-125.

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The review summarizes the key research results in the development of methods and approaches to the production of cyclic acetals based on petrochemical products. The use of 1,3-dioxacyclanes in the synthesis of a number of practically important compounds, including biologically active ones, is briefly noted. The use of 1,3-dioxacycloalkanes in the synthesis of polyfunctional heterocyclic compounds is considered separately. The possibilities of using synthesized substances as biologically active compounds are shown.
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50

El-Behairy, Mohammed Farrag, Rasha M. Hassan, and Eirik Sundby. "Enantioselective Chromatographic Separation and Lipase Catalyzed Asymmetric Resolution of Biologically Important Chiral Amines." Separations 8, no. 10 (2021): 165. http://dx.doi.org/10.3390/separations8100165.

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Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or methoxyacetamides RS-(1b–4b) in enantiopure/enriched form was investigated. Compounds S-1, S-2, R-1b, R-1a, andR-2b were prepared in enantiopure form (ee &gt; 99%) while compounds S-4, R-2a, and R-4a were achieved in ee 9%, 80%, and 76%, respectively. Many baselines enantioselective HPLC separations of amines 1–4, their cyanoacetamides (1a–4a), and methoxyacetamides (1b–4b) were
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