Log in

Relevant bibliographies by topics / Biologiya fani / Journal articles

To see the other types of publications on this topic, follow the link: Biologiya fani.

Journal articles on the topic 'Biologiya fani'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Biologiya fani.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

PARDAYEVA, Matonat. "BO‘LAJAK BIOLOGIYA O‘QITUVCHILARIDA ILMIY – METODIK KOMPETENTLIKNI SHAKLLANTIRISH USULLARI." UzMU xabarlari 1, no. 1.5.1 (2024): 178–80. https://doi.org/10.69617/nuuz.v1i1.5.1.4760.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Uchkun, Raxmatov. "Talabalarni kasbiy kompetentligini rivojlantirishda integrativ bilimlardan foydalanish metodikasi." Maktabgacha va maktab ta'limi jurnali 1, no. 8 (2024): 5–8. https://doi.org/10.5281/zenodo.14616047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Muxammadjonova, Madinaxon. "KIMYO FANI TA'LIMINING DOLZARB MUAMMOLARI." ilm-fan 1, no. 24 (2023): 22–23. https://doi.org/10.5281/zenodo.8413826.

Full text

Abstract:

Qadim zamonlardan beri insoniyat ovqatlanishi, kiyinishi va boshpana qurib yashashi uchun atrofida mavjud bo’lgan narsalar, jismlardan foydalanib kelgan. Bunday ehtiyojlarning qonishi keyinchalik kimyo fani rivojlanishiga olib keldi. Kimyo fani tabiiy fanlar qatoriga kiradi va shuning uchun biologiya va fizika fanlari ham moddalarnng tarkibi, xususiyatlari va ishlatilishi bilan shug’ullanadi. Kimyo materiyada sodir bo’ladigan o’zgarishlarni tartibga soluvchi tamoyillarni o’rganadi.

APA, Harvard, Vancouver, ISO, and other styles

4

Yuldasheva, Malika Berdiyarovna. "PEDAGOGIK OLIY TA'LIM MUASSALARIDA "MOLEKULYAR BIOLOGIYA" FANINING O'QITILISHINI INNOVATSION YONDASHUV ASOSIDA TASHKIL ETILISHI." Educational Research in Universal Sciences 1, no. 6 (2022): 440–42. https://doi.org/10.5281/zenodo.7491719.

Full text

Abstract:

maqolada bo‘lajak biologiya fani o‘qituvchilarini tayyorlashda fundamental fan -molekulyar biologiyani o‘qitishga yangicha yondashuvning asosiy omillari to‘g‘risida so‘z boradi.

APA, Harvard, Vancouver, ISO, and other styles

5

Abduraximova, Feruzabonu Asqar qizi, and Gulsara Temirqulovna Ro'ziyeva. "TIBBIY BIOLOGIYA FANIDAN HAYOTNING HUJAYRAVIY ASOSLARI MAVZUSINI O'QITISHDA PEDOGOGIK TEXNOLAGIYALARDAN FOYDALANISH SAMARADORLIGI." JOURNAL OF UNIVERSAL SCIENCE RESEARCH 1, no. 5 (2023): 984–89. https://doi.org/10.5281/zenodo.7952578.

Full text

Abstract:

Tibbiyot oliy ta’lim muassasalarida Tibbiy biologiya. Umumiy genetika fani asosiy fanlardan biri hisoblanadi. Bu fanni yaxshi o’zlashtirgan talabalar tibbiyot olamini chuqurroq anglashi oson bo’ladi. Shu sababli tibbiy biologiya fanini o’qitishning yangi axborot va peadagogik texnologiyalarini yaratish muhim dolzarb masala hisoblanadi. Ushbu maqolada tibbiy biologiya fanidan hayotning hujayra asoslari mavzusini o’qitishda yangi pedagogik texnologiyalarni qo’llash imkoniyatlari o’rganilgan. Ilmiy adabiyotlar troflicha tahlil qilingan va eng qulay va sam

APA, Harvard, Vancouver, ISO, and other styles

6

Dilso'z, Quldosheva. "Biologiya darslari ekologik ta'lim va tarbiyani rivojlantirish omili sifatida." «Maktabgacha va maktab ta'limi» jurnali 3, no. 5 (2025): 12–15. https://doi.org/10.5281/zenodo.15584966.

Full text

Abstract:

Mazkur ishda biologiya darslarining ekologik ta’lim va tarbiyani rivojlantirishdagi o‘rni tahlil qilingan.Biologiya fani o‘quvchilarda tabiatga bo‘lgan mas’uliyatli munosabatni shakllantirish, ekologik ongni rivojlantirish va tabiatresurslaridan barqaror foydalanishni o‘rgatishda muhim ahamiyatga ega. Darslar ekologik muammolarni tushunishgayordam beradi va yosh avlodni atrof-muhitni saqlashga undaydi. O‘quvchilarga yashil iqtisodiyot, barqaror rivojlanish vaekologik xavfsizlik haqida ma’lumot berish orqali ular o‘z hayotlarida to‘g&l

APA, Harvard, Vancouver, ISO, and other styles

7

M., R. Hayitov. "Tarbiya koloniyasi o'quvchilarining kreativ fikrlash layoqatini shakllantirishning ayrim jihatlari (Biologiya o'quv fani misolida)." «Maktabgacha va maktab ta'limi» jurnali 3, no. 2 (2025): 7–10. https://doi.org/10.5281/zenodo.14939361.

Full text

Abstract:

Mazkur maqolada tarbiya koloniyalarida tahsil olayotgan o‘quvchilarga biologiya fanini o‘qitish jarayonidakreativ fikrlash layoqatini shakllantirishning o‘ziga xos xususiyatlari bayon etilgan.

APA, Harvard, Vancouver, ISO, and other styles

8

Кadirova, Latofat Talatovna. "MAKTABIM FAXRIM MENING." O'qituvchi 3, no. 7 (2022): 8–9. https://doi.org/10.5281/zenodo.6387323.

Full text

Abstract:

Joriy yilning 15.02.2022-yil kuni Toshkent shahar, Yunusobod tumanidagi 271- sonli maktabda shu hududda joylashgan barcha maktablarning kimyo va biologiya fani òqituvchilari uchun O’zbekiston Respublikasi Prezidentining 2020 yil 12 avgustdagi PQ - 4805 qarori ijrosini ta'minlash maqsadida, ilmiy-amaliy seminar tashkil etildi. Seminarda ToshPTI qoshidagi akademik litsey o‘qituvchisi X.Sobirov, Kimyo Тexnologiyalar Instituti qoshidagi akademik litsey o’qituvchisi N.Hasanova, Yunusobod tumani XTB tabiiy fanlar metodisti H.N.Jalolov, 271-sonli maktab direktori L.T.Kadi

APA, Harvard, Vancouver, ISO, and other styles

9

M.A.Farmonova. "MOBIL ILOVALAR ORQALI OʻQITISH META-TA'LIMNING TARKIBIY QISMI SIFATIDA OʻRNI VA FOYDALANISH SAMARADORLIGI". ilm-fan 1, № 17 (2023): 102–5. https://doi.org/10.5281/zenodo.8153214.

Full text

Abstract:

Mazkur maqola oliy ta’lim muassasalarida yetuk, har tomonlama shakllangan, ilg’or texnologiyali bilimlar bilan qurollangan mutaxassislar yetishtiish maqsadida ta’limda qoʻllaniladigan eng soʻngi texnologiyalar haqida ma’lumotlar keltirilgan. Xususan oliy ta’lim muassasalarida biologiya fanlar turkumidan Botanika fani oʻqitish samaradorligini oshirishga qaratilgan mobil- metodik guruhlar faoliyatining nazariy va amaliy ahamiyati boʻyicha ilmiy fikr mulohazalar keltirilgan. Zamonaviy ta’lim turi boʻlgan Meta-ta’lim mobil ilovali texnologiyalar bilan qoʻl

APA, Harvard, Vancouver, ISO, and other styles

10

Qarshiboyev, Jahongir Hazratqulovich, Ilhom Abdurahmonov, and Dilrabo Shodiyeva. "MIRZACHO'LDA TARQALGAN BURCHOQDOSHLAR." O'ZBEKISTONDA FANLARARO INNOVATSIYALAR VA ILMIY TADQIQOTLAR JURNALI 2, no. 18 (2023): 60–64. https://doi.org/10.5281/zenodo.7834201.

Full text

Abstract:

<em>Dunyo aholisining soni yildan yilga ortib bormoqda. Binobarin, biologiya fani oldida turgan muhim vazifalardan biri insonlarning oziq-ovqatga bo’lgan ehtiyojini qondirishga qaratilgan nazariy va amaliy muammolarni hal etishdan iborat. </em><em>Oqsil-kishilik hayotidagi asosiy rol o’ynovchi hech narsa bilan almashtirib bo’lmaydigan moddadir</em><em>. Hayvon oqsili qimmat bo’lgani uchun aholini arzon va sifatli o’simlik oqsili mahsulotlari bilan taminlashdek dolzarb muamo turibdi, bu borada eng yaxshi yechim bu burchoqdoshlar oilasi vakillarini ko’proq o&r

APA, Harvard, Vancouver, ISO, and other styles

11

Axmedova, Mavjuda Turg'unovna. "BIOLOGIYA DARSLARIDA INTERFAOL METODLARDAN FOYDALANISH." PEDAGOGS international research journal 2, no. 1 (2022): 208–15. https://doi.org/10.5281/zenodo.5920050.

Full text

Abstract:

<strong>Annotatsiya: </strong>Taqdim etilayotgan bu maqolada biologiya darslarida qo’llaniladigan samarali interfaol usullar, tadbir va ochiq dars ishlanmalaridan namunalar keltirilgan bo’lib, bu jamlanma biologiya fani o’qituvchilari uchun xizmat qilsa ajab emas. <strong>1.“Kamalak” usuli .</strong> Bu usulni biror bob yoki bo’lim yuzasidan o’tkazish mumkin.Bunda birinchi ustindagi asosiy tushunchalar har xil ranglarda beriladi. Jadvalning qolgan qismlarida so’zlar aralash yozilgan bo’ladi. O’quvchilar ushbu tushunchalarni asosiy tus

APA, Harvard, Vancouver, ISO, and other styles

12

Cheung, Ronald S., Maria Castella, and Toshiyasu Taniguchi. "Disparate Requirements for the Phosphorylation of Distinct Sites on the Fanconi Anemia Group I Protein." Blood 124, no. 21 (2014): 358. http://dx.doi.org/10.1182/blood.v124.21.358.358.

Full text

Abstract:

Abstract Fanconi Anemia (FA) is a blood disorder characterized by bone marrow failure, predisposition to hematologic malignancy and sensitivity to interstrand crosslinking agents. Patients with FA carry inherited mutations in any one of at least 16 known Fanconi Anemia Group (FANC) proteins that coordinate to function in a DNA repair pathway (the FA pathway). The activation of this pathway centers on two of these, Fanconi Anemia Group D2 protein (FANCD2) and Fanconi Anemia Group I protein (FANCI), which must undergo both phosphorylation and ubiquitination in order for the pathway to function p

APA, Harvard, Vancouver, ISO, and other styles

13

Shain, Kenneth H., Vasco Oliveira, Danielle Yarde, Linda Mathews, and William S. Dalton. "A Novel Upregulation of Fanconi Anemia/BRCA DNA Repair Pathway Is Observed Upon Co-Culture of Bone Marrow Stroma with Multiple Myeloma Cell Lines: A Potential New Participant(s) in Environment Mediated Drug Resistance." Blood 114, no. 22 (2009): 2798. http://dx.doi.org/10.1182/blood.v114.22.2798.2798.

Full text

Abstract:

Abstract Abstract 2798 Poster Board II-774 Multiple Myeloma (MM) is an incurable malignancy of mature clonal B cells. The refractory nature of MM has long been attributed to the acquisition of drug resistance. Traditionally, mechanisms of drug resistance have been defined by acquired changes in the expression or function of specific gene products. To this end, we have recently demonstrated that selected resistance to the cytotoxic agent melphalan correlated with increased expression of components of the Fanconi Anemia (FA)/BRCA DNA repair pathway and a concomitant increase in repair of DNA int

APA, Harvard, Vancouver, ISO, and other styles

14

Fang, Fang. "Fang Fang." Current Biology 21, no. 12 (2011): R444—R446. http://dx.doi.org/10.1016/j.cub.2011.04.042.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Pipaon, Carlos, Sara Bravo Navas, Iñigo Romon, Eulogio Conde, and Lucrecia Yanez San Segundo. "Elevated FANCA Expression Marks a Worse Prognosis in Chronic Lymphocytic Leukemia. Evidence of a New Role of FANCA in the Stability of p53 By a Neddylation-Related Mechanism." Blood 132, Supplement 1 (2018): 5541. http://dx.doi.org/10.1182/blood-2018-99-113398.

Full text

Abstract:

Abstract Background: Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries. It is characterized by a failure in the mechanisms of apoptosis that leads to an accumulation of mature B cells in peripheral blood, bone marrow and lymphoid organs. With exceptions, CLL is considered incurable and some patients show a worse prognosis related to the expression of certain cytogenetic or molecular markers such as p53 dysfunction (17p13 deletion or TP53 inactivation), 11q23 deletion, unmutated IgVH and the presence of a complex karyotype. FANC proteins have be

APA, Harvard, Vancouver, ISO, and other styles

16

Fain, Gordon. "Gordon Fain." Current Biology 26, no. 5 (2016): R184—R185. http://dx.doi.org/10.1016/j.cub.2016.01.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Airik, Merlin, Haley Arbore, Elizabeth Childs, et al. "Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys." Antioxidants 12, no. 4 (2023): 900. http://dx.doi.org/10.3390/antiox12040900.

Full text

Abstract:

Karyomegalic interstitial nephritis (KIN) is a genetic adult-onset chronic kidney disease (CKD) characterized by genomic instability and mitotic abnormalities in the tubular epithelial cells. KIN is caused by recessive mutations in the FAN1 DNA repair enzyme. However, the endogenous source of DNA damage in FAN1/KIN kidneys has not been identified. Here we show, using FAN1-deficient human renal tubular epithelial cells (hRTECs) and FAN1-null mice as a model of KIN, that FAN1 kidney pathophysiology is triggered by hypersensitivity to endogenous reactive oxygen species (ROS), which cause chronic

APA, Harvard, Vancouver, ISO, and other styles

18

Fang, Emily, Campbell Bunce, Philip Payne, et al. "Abstract 1537: DRIVE-Biologics: All the steps from discovery to development of novel biological entities." Cancer Research 83, no. 7_Supplement (2023): 1537. http://dx.doi.org/10.1158/1538-7445.am2023-1537.

Full text

Abstract:

Abstract Biologics first revolutionized cancer treatment in the late 1900s with the approval of rituximab and trastuzumab, two monoclonal antibodies targeting antigens expressed on tumor cells. Another milestone was achieved in the early 2010s with the approval of antibodies targeting immune checkpoints. Nowadays, the discovery and development of new biological entities and biological therapeutic products represent a rapidly growing market in various therapeutic areas, with about 10 to 15 biologics being approved each year. We have built a premium expert ecosystem services - DRIVE-Biologics -

APA, Harvard, Vancouver, ISO, and other styles

19

Li, Shengguo, and Sungkyoo Hong. "A Study on the Elements of Literature by Analyzing the Lyrics of “Chinese Style” by Fang Wenshan." Korean Society of Culture and Convergence 44, no. 7 (2022): 743–53. http://dx.doi.org/10.33645/cnc.2022.7.44.7.743.

Full text

Abstract:

This study is an in-depth analysis of the Chinese-style work of modern Chinese lyricist Fang Wen shan. Fang Wen shan's work has been evaluated as a lyric containing ancient elements, so the characteristics of creation and literary elements contained in the lyrics of the song “Fa Ru Xue” were studied. To this end, in order to analyze the characteristics of the rhyme, artistic conception, and rhetoric of the notice contained in the lyrics, Fang When san’s creative career was investigated, and previous studies on Fang Wen shan’s work were found. Through prior research on Fang Wen shan’s work, the

APA, Harvard, Vancouver, ISO, and other styles

20

Hoang, Tung T., and Herbert P. Schweizer. "Characterization of Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI): a Target for the Antimicrobial Triclosan and Its Role in Acylated Homoserine Lactone Synthesis." Journal of Bacteriology 181, no. 17 (1999): 5489–97. http://dx.doi.org/10.1128/jb.181.17.5489-5497.1999.

Full text

Abstract:

ABSTRACT The Pseudomonas aeruginosa fabI structural gene, encoding enoyl-acyl carrier protein (ACP) reductase, was cloned and sequenced. Nucleotide sequence analysis revealed that fabIis probably the last gene in a transcriptional unit that includes a gene encoding an ATP-binding protein of an ABC transporter of unknown function. The FabI protein was similar in size and primary sequence to other bacterial enoyl-ACP reductases, and it contained signature motifs for the FAD-dependent pyridine nucleotide reductase and glucose/ribitol dehydrogenase families, respectively. The chromosomal fabIgene

APA, Harvard, Vancouver, ISO, and other styles

21

Ting, Ya-Chih, Horng-Huey Ko, Hui-Chun Wang, et al. "Biological evaluation of secondary metabolites from the roots of Myrica adenophora." Phytochemistry 103 (July 31, 2014): 89–98. https://doi.org/10.1016/j.phytochem.2014.04.003.

Full text

Abstract:

Ting, Ya-Chih, Ko, Horng-Huey, Wang, Hui-Chun, Peng, Chien-Fang, Chang, Hsun-Shuo, Hsieh, Pei-Chen, Chen, Ih-Sheng (2014): Biological evaluation of secondary metabolites from the roots of Myrica adenophora. Phytochemistry 103: 89-98, DOI: 10.1016/j.phytochem.2014.04.003, URL: http://dx.doi.org/10.1016/j.phytochem.2014.04.003

APA, Harvard, Vancouver, ISO, and other styles

22

Liu, Haibin, Junfen Xu, Yanqin Yang, et al. "Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1." Proceedings of the National Academy of Sciences 118, no. 3 (2021): e2014195118. http://dx.doi.org/10.1073/pnas.2014195118.

Full text

Abstract:

Long noncoding RNAs (lncRNAs) play diverse roles in biological processes, but their expression profiles and functions in cervical carcinogenesis remain unknown. By RNA-sequencing (RNA-seq) analyses of 18 clinical specimens and selective validation by RT-qPCR analyses of 72 clinical samples, we provide evidence that, relative to normal cervical tissues, 194 lncRNAs are differentially regulated in high-risk (HR)-HPV infection along with cervical lesion progression. One such lncRNA, lnc-FANCI-2, is extensively characterized because it is expressed from a genomic locus adjacent to the FANCI gene e

APA, Harvard, Vancouver, ISO, and other styles

23

Pan, Yue, Yuwei Hu, Xingmiao Zhou, Li Fang, and Chaoliang Lei. "Biological Characteristics and Environmental Adaptation of Four Phenotypes ofPropylea japonica(Thunberg) (Coleoptera: Coccinellidae)." Coleopterists Bulletin 64, no. 3 (2010): 249–55. https://doi.org/10.1649/0010-065x-64.3.249.11.

Full text

Abstract:

Pan, Yue, Hu, Yuwei, Zhou, Xingmiao, Fang, Li, Lei, Chaoliang (2010): Biological Characteristics and Environmental Adaptation of Four Phenotypes ofPropylea japonica(Thunberg) (Coleoptera: Coccinellidae). The Coleopterists Bulletin 64 (3): 249-255, DOI: 10.1649/0010-065x-64.3.249.11, URL: http://dx.doi.org/10.1649/0010-065x-64.3.249.11

APA, Harvard, Vancouver, ISO, and other styles

24

Colnaghi, Luca, Mathew J. K. Jones, Xiomaris M. Cotto-Rios, Detlev Schindler, Helmut Hanenberg, and Tony T. Huang. "Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair." Blood 117, no. 7 (2011): 2247–56. http://dx.doi.org/10.1182/blood-2010-07-295758.

Full text

Abstract:

Abstract Fanconi anemia (FA) is a rare familial genome instability syndrome caused by mutations in FA genes that results in defective DNA crosslink repair. Activation of the FA pathway requires the FA core ubiquitin ligase complex-dependent monoubiquitination of 2 interacting FA proteins, FANCI and FANCD2. Although loss of either FANCI or FANCD2 is known to prevent monoubiquitination of its respective partner, it is unclear whether FANCI has any additional domains that may be important in promoting DNA repair, independent of its monoubiquitination. Here, we focus on an FA-I patient-derived FAN

APA, Harvard, Vancouver, ISO, and other styles

25

Moriel-Carretero, María, Sara Ovejero, Marie Gérus-Durand, Dimos Vryzas, and Angelos Constantinou. "Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors." Journal of Cell Biology 216, no. 12 (2017): 4007–26. http://dx.doi.org/10.1083/jcb.201702136.

Full text

Abstract:

Proteins disabled in the cancer-prone disorder Fanconi anemia (FA) ensure the maintenance of chromosomal stability during DNA replication. FA proteins regulate replication dynamics, coordinate replication-coupled repair of interstrand DNA cross-links, and mitigate conflicts between replication and transcription. Here we show that FANCI and FANCD2 associate with splicing factor 3B1 (SF3B1), a key spliceosomal protein of the U2 small nuclear ribonucleoprotein (U2 snRNP). FANCI is in close proximity to SF3B1 in the nucleoplasm of interphase and mitotic cells. Furthermore, we find that DNA replica

APA, Harvard, Vancouver, ISO, and other styles

26

Massengo-Tiassé, R. Prisca, and John E. Cronan. "Vibrio cholerae FabV Defines a New Class of Enoyl-Acyl Carrier Protein Reductase." Journal of Biological Chemistry 283, no. 3 (2007): 1308–16. http://dx.doi.org/10.1074/jbc.m708171200.

Full text

Abstract:

Enoyl-acyl carrier protein (ACP) reductase catalyzes the last step of the fatty acid elongation cycle. The paradigm enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan. However, some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK and FabL. The genome of the Gram-negative bacterium, Vibrio cholerae lacks a gene encoding a homologue of any of the three known enoyl-ACP reductase isozymes suggesting that this organism encodes a novel fou

APA, Harvard, Vancouver, ISO, and other styles

27

Goodwin, Joel T. L., Simon P. Pawlowski, Peter D. Mayo, Peter J. Silk, Jon D. Sweeney, and N. Kirk Hillier. "Influence of trap colour, type, deployment height, and a host volatile on monitoring Orchestes fagi (Coleoptera: Curculionidae) in Nova Scotia, Canada." Canadian Entomologist 152, no. 1 (2019): 98–109. http://dx.doi.org/10.4039/tce.2019.63.

Full text

Abstract:

AbstractOrchestes fagi (Linnaeus) (Coleoptera: Curculionidae) is a pest of beech trees (Fagus sylvatica Linnaeus; Fagaceae) in Europe that has recently become established and invasive on American beech (Fagus grandifolia Ehrhart) in Nova Scotia, Canada. We tested the effects of trap type, trap colour, trap height, and lure on the numbers of O. fagi captured per trap with the objective of developing a survey tool to monitor the weevil’s spread. We captured O. fagi in significantly greater numbers on yellow, green, or white traps than on light blue, dark blue, or red traps. There were no signifi

APA, Harvard, Vancouver, ISO, and other styles

28

Mauro, Francesca R., Elena Giammartini, Maria S. De Propris, et al. "Fludarabine, Ara-C, Novantrone and Dexamethasone Plus Campath-1H for the Treatment of Patients with Chronic Lymphocytic Leukemia (CLL) and Adverse Clinical and Biologic Prognostic Features." Blood 108, no. 11 (2006): 2830. http://dx.doi.org/10.1182/blood.v108.11.2830.2830.

Full text

Abstract:

Abstract This study was conducted to determine the feasibility, safety and efficacy of the FAND plus Campath-1H combination (FAND-Cam) given to 19 previously treated CLL patients with adverse prognostic features. The median age was 55 years (range 43–65), the median duration of CLL was 68 months; 89 % of patients were unmutated, 74% CD38+ and 75% ZAP-70+. A 17p− deletion was observed in 5/11 evaluable cases. The median number of prior treatments was 2 (range 1–6). Seventeen patients (89%) were refractory to prior therapy, which included fludarabine in 14 (fludarabine, n = 3; fludarabine-cyclop

APA, Harvard, Vancouver, ISO, and other styles

29

Pierer, M., U. Wagner, C. Baerwald, and O. Malysheva. "Indikationen und Wirksamkeit der Anti-TNF-Therapie." Arthritis und Rheuma 29, no. 04 (2009): 205–13. http://dx.doi.org/10.1055/s-0037-1620170.

Full text

Abstract:

ZusammenfassungRheumatische Erkrankungen sind schwere Erkrankungen, die mit anhaltenden Schmerzen einhergehen, zum Verlust an Lebensqualität, Funktion, Arbeitsfähigkeit und auch zur Verkürzung des Lebens führen können. Sie verursachen erhebliche Kosten für das Gesundheitssystem. Mehrere Biologika als neue „disease modifying antirheumatic drugs“ sind in die Therapie von rheumatoider Arthritis, Spondyloarthropathien, Psoriasis-Arthritis und idiopathischer juveniler Arthritis eingeführt worden. Es fand sich eine zum Teil große Effektivität der Biologika, wobei dieser Artikel sich auf die Anti-TNF

APA, Harvard, Vancouver, ISO, and other styles

30

Broeckhoven, Chris, and Anton du Plessis. "Has snake fang evolution lost its bite? New insights from a structural mechanics viewpoint." Biology Letters 13, no. 8 (2017): 20170293. http://dx.doi.org/10.1098/rsbl.2017.0293.

Full text

Abstract:

Venomous snakes—the pinnacle of snake evolution—are characterized by their possession of venom-conducting fangs ranging from grooved phenotypes characterizing multiple lineages of rear-fanged taxa to tubular phenotypes present in elapids, viperids and atractaspidines. Despite extensive research, controversy still exists on the selective pressures involved in fang phenotype diversification. Here, we test the hypothesis that larger fangs and consequently a shift to an anterior position in the maxilla evolved to compensate for the costs of structural changes, i.e. higher stress upon impact in tub

APA, Harvard, Vancouver, ISO, and other styles

31

Zhu, Weile, Huiyang Wang, Yuheng Wang, Shengde Liu, Jianglei Di, and Liyun Zhong. "Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance." Nanomaterials 14, no. 24 (2024): 2036. https://doi.org/10.3390/nano14242036.

Full text

Abstract:

The in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal enhancement in recent years. However, biological cells are often immersed in different formulations of culture medium with varying refractive indexes and are highly sensitive to the temperature of the microenvironment. This necessitates that SERS meets the requirements of refractive index insensitivit

APA, Harvard, Vancouver, ISO, and other styles

32

Enderle, Janina, Annika Dorn, and Holger Puchta. "DNA- and DNA-Protein-Crosslink Repair in Plants." International Journal of Molecular Sciences 20, no. 17 (2019): 4304. http://dx.doi.org/10.3390/ijms20174304.

Full text

Abstract:

DNA-crosslinks are one of the most severe types of DNA lesions. Crosslinks (CLs) can be subdivided into DNA-intrastrand CLs, DNA-interstrand CLs (ICLs) and DNA-protein crosslinks (DPCs), and arise by various exogenous and endogenous sources. If left unrepaired before the cell enters S-phase, ICLs and DPCs pose a major threat to genomic integrity by blocking replication. In order to prevent the collapse of replication forks and impairment of cell division, complex repair pathways have emerged. In mammals, ICLs are repaired by the so-called Fanconi anemia (FA) pathway, which includes 22 differen

APA, Harvard, Vancouver, ISO, and other styles

33

Doekes, Harmen P., Ino Curik, István Nagy, János Farkas, György Kövér, and Jack J. Windig. "Revised Calculation of Kalinowski’s Ancestral and New Inbreeding Coefficients." Diversity 12, no. 4 (2020): 155. http://dx.doi.org/10.3390/d12040155.

Full text

Abstract:

To test for the presence of purging in populations, the classical pedigree-based inbreeding coefficient (F) can be decomposed into Kalinowski’s ancestral (FANC) and new (FNEW) inbreeding coefficients. The FANC and FNEW can be calculated by a stochastic approach known as gene dropping. However, the only publicly available algorithm for the calculation of FANC and FNEW, implemented in GRain v 2.1 (and also incorporated in the PEDIG software package), has produced biased estimates. The FANC was systematically underestimated and consequently, FNEW was overestimated. To illustrate this bias, we cal

APA, Harvard, Vancouver, ISO, and other styles

34

Ali, Abdullah M., Changhu Du, Thiyam R. Singh, and Ruhikanta A. Meetei. "Elucidating the Molecular Architecture of the FA-Core Complex Utilizing Biochemical Purification Approach." Blood 110, no. 11 (2007): 1683. http://dx.doi.org/10.1182/blood.v110.11.1683.1683.

Full text

Abstract:

Abstract FA is a rare, recessive disorder characterized by progressive bone marrow failure, developmental abnormalities, chromosome instability, cellular hypersensitivity to DNA cross-linking agents, and predisposition to cancer, mainly leukemias and squamous cell carcinomas of the head and neck. FA is genetically heterogeneous, represented by at least thirteen different complementation groups. The genes corresponding to groups A, B, C, D1 (BRCA2), D2, E, F, G, I, J, L, M and N have been cloned. The Fanconi proteins FANC -A, -B, -C, -E, -F, -G, -L, -M along with another newly discovered protei

APA, Harvard, Vancouver, ISO, and other styles

35

Loupe, Jacob M., Ricardo Mouro Pinto, Kyung-Hee Kim, et al. "Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out." Human Molecular Genetics 29, no. 18 (2020): 3044–53. http://dx.doi.org/10.1093/hmg/ddaa196.

Full text

Abstract:

Abstract Recent genome-wide association studies of age-at-onset in Huntington’s disease (HD) point to distinct modes of potential disease modification: altering the rate of somatic expansion of the HTT CAG repeat or altering the resulting CAG threshold length-triggered toxicity process. Here, we evaluated the mouse orthologs of two HD age-at-onset modifier genes, FAN1 and RRM2B, for an influence on somatic instability of the expanded CAG repeat in Htt CAG knock-in mice. Fan1 knock-out increased somatic expansion of Htt CAG repeats, in the juvenile- and the adult-onset HD ranges, whereas knock-

APA, Harvard, Vancouver, ISO, and other styles

36

Maung, Kyaw Zeya, James X. Gray, Paul J. Leo, et al. "Whole Exome Sequencing of Acute Myeloid Leukaemia Patients Identifies Somatic and Germline Mutations in Fanconi Anaemia Genes." Blood 124, no. 21 (2014): 698. http://dx.doi.org/10.1182/blood.v124.21.698.698.

Full text

Abstract:

Abstract Introduction - AML is a complex group of malignancies, with heterogeneity in morphology, cytogenetics, molecular characteristics, aggressiveness and importantly, in its response to treatment and survival outcomes. Next generation sequencing by the Cancer Genome Atlas Research Network analysed 200 primary AML cases and identified 23 genes that display recurrent somatic mutations at varying frequency in AML (NEJM 368(22):2059-2074). Defects in DNA repair are frequently identified in treatment-related AML and inherited mutations in genes of DNA repair pathways predispose patients to myel

APA, Harvard, Vancouver, ISO, and other styles

37

Reich-Slotky, Ronit, Christina A. Kabbash, Phyllis Della-Latta, et al. "Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages." Journal of Bacteriology 191, no. 16 (2009): 5262–71. http://dx.doi.org/10.1128/jb.00175-09.

Full text

Abstract:

ABSTRACT We report here that gemfibrozil (GFZ) inhibits axenic and intracellular growth of Legionella pneumophila and of 27 strains of wild-type and multidrug-resistant Mycobacterium tuberculosis in bacteriological medium and in human and mouse macrophages, respectively. At a concentration of 0.4 mM, GFZ completely inhibited L. pneumophila fatty acid synthesis, while at 0.12 mM it promoted cytoplasmic accumulation of polyhydroxybutyrate. To assess the mechanism(s) of these effects, we cloned an L. pneumophila FabI enoyl reductase homolog that complemented for growth an Escherichia coli strain

APA, Harvard, Vancouver, ISO, and other styles

38

Li, Landing, Winnie Tan, and Andrew J. Deans. "Structural insight into FANCI–FANCD2 monoubiquitination." Essays in Biochemistry 64, no. 5 (2020): 807–17. http://dx.doi.org/10.1042/ebc20200001.

Full text

Abstract:

Abstract The Fanconi anemia (FA) pathway coordinates a faithful repair mechanism for DNA damage that blocks DNA replication, such as interstrand cross-links. A key step in the FA pathway is the conjugation of ubiquitin on to FANCD2 and FANCI, which is facilitated by a large E3 ubiquitin ligase complex called the FA core complex. Mutations in FANCD2, FANCI or FA core complex components cause the FA bone marrow failure syndrome. Despite the importance of these proteins to DNA repair and human disease, our molecular understanding of the FA pathway has been limited due to a deficit in structural s

APA, Harvard, Vancouver, ISO, and other styles

39

Vinciguerra, Patrizia, Susana Godinho, Kalindi Parmar, David Pellman, and Alan D'Andrea. "Cytokinesis Failure in Fanconi Anemia Pathway Deficient Murine Hematopoietic Stem Cells." Blood 114, no. 22 (2009): 495. http://dx.doi.org/10.1182/blood.v114.22.495.495.

Full text

Abstract:

Abstract Abstract 495 Fanconi Anemia (FA) is a rare recessive chromosomal-instability disorder characterized by congenital malformations, a high predisposition to cancer, and progressive bone marrow failure. FA is genetically heterogeneous and, to date, thirteen FA genes have been identified (FANCA, -B, -C, -D1, -D2, -E, -F, -G, -I, -J, -L, -M, -N). The thirteen encoded FA proteins cooperate in a common DNA repair pathway active during the Synthesis (S) phase of the cell cycle. DNA damage detected during replication results in the monoubiquitination of two FA proteins, FANCD2 and FANCI, that t

APA, Harvard, Vancouver, ISO, and other styles

40

Qiang, Ze-xuan, Yi-shen Qiu, Hui Li, Ji-bo Bai, and Xiyao Chen. "Study of 2-D photon crystal Fano slab filters for biological sensing." Optoelectronics Letters 5, no. 4 (2009): 260–62. http://dx.doi.org/10.1007/s11801-009-9011-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Casadio, Melina. "Fanni Gergely: Exploring centrosome biology." Journal of Cell Biology 215, no. 3 (2016): 294–95. http://dx.doi.org/10.1083/jcb.2153pi.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Mekinian, A., M. Vautier, M. Resche-Rigon та ін. "AB0508 EFFICACY AND SAFETY OF TNF-Α ANTAGONISTS AND TOCILIZUMAB IN TAKAYASU ARTERITIS: MULTICENTER EUROPEAN RETROSPECTIVE STUDY OF 203 PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1552.2–1552. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3574.

Full text

Abstract:

Background:Takayasu arteritis (TA) is a chronic inflammatory large-vessel vasculitis, predominantly affecting the aorta and its main branchesObjectives:To assess safety and efficacy of biologics (i.e. TNF-α antagonists and tocilizumab) in patients with Takayasu arteritis (TA).Methods:We conducted a retrospective multicenter study in referral centers from Europe and several countries in the world about biological-targeted therapies in Takayasu arteritis during the period from January 2017 to September 2019.Results:Retrospective multicenter study of characteristics and outcome of 49 TA patients

APA, Harvard, Vancouver, ISO, and other styles

43

Rajdl, Kamil, and Petr Lansky. "Fano factor estimation." Mathematical Biosciences and Engineering 11, no. 1 (2014): 105–23. http://dx.doi.org/10.3934/mbe.2014.11.105.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Maung, Kyaw Ze Ya, Paul Leo, Anna L. Brown, et al. "Rare Variants Affecting the Fanconi Anaemia DNA Repair Genes Associate with Increased Risk for AML." Blood 128, no. 22 (2016): 41. http://dx.doi.org/10.1182/blood.v128.22.41.41.

Full text

Abstract:

Abstract While there have been extensive studies to define the roles of recurrent somatic mutations in AML, the contribution of germline variants to AML initiation and progression is less well established. DNA repair disorders often predispose patients to developing myeloid malignancies. In particular, biallelic mutations affecting FANC genes cause the recessive heritable bone marrow failure syndrome Fanconi Anemia (FA), which is associated with >800-fold increased risk of progression to AML. A recent explosion of cancer predisposition studies has also revealed the importance of germlineFAN

APA, Harvard, Vancouver, ISO, and other styles

45

Radka, Christopher D., Matthew W. Frank, Jiangwei Yao, Jayaraman Seetharaman, Darcie J. Miller, and Charles O. Rock. "The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)." Journal of Biological Chemistry 295, no. 22 (2020): 7635–52. http://dx.doi.org/10.1074/jbc.ra120.013336.

Full text

Abstract:

Enoyl-acyl carrier protein reductase (FabI) catalyzes a rate-controlling step in bacterial fatty-acid synthesis and is a target for antibacterial drug development. A phylogenetic analysis shows that FabIs fall into four divergent clades. Members of clades 1–3 have been structurally and biochemically characterized, but the fourth clade, found in members of phylum Bacteroidetes, is uncharacterized. Here, we identified the unique structure and conformational changes that distinguish clade 4 FabIs. Alistipes finegoldii is a prototypical Bacteroidetes inhabitant of the gut microbiome. We found that

APA, Harvard, Vancouver, ISO, and other styles

46

KAPOOR, Mili, C. Chandramouli REDDY, M. V. KRISHNASASTRY, Namita SUROLIA, and Avadhesha SUROLIA. "Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan." Biochemical Journal 381, no. 3 (2004): 719–24. http://dx.doi.org/10.1042/bj20031821.

Full text

Abstract:

Triclosan is a potent inhibitor of FabI (enoyl-ACP reductase, where ACP stands for acyl carrier protein), which catalyses the last step in a sequence of four reactions that is repeated many times with each elongation step in the type II fatty acid biosynthesis pathway. The malarial parasite Plasmodium falciparum also harbours the genes and is capable of synthesizing fatty acids by utilizing the enzymes of type II FAS (fatty acid synthase). The basic differences in the enzymes of type I FAS, present in humans, and type II FAS, present in Plasmodium, make the enzymes of this pathway a good targe

APA, Harvard, Vancouver, ISO, and other styles

47

Maltarollo, Vinicius Gonçalves. "Classification of Staphylococcus Aureus FabI Inhibitors by Machine Learning Techniques." International Journal of Quantitative Structure-Property Relationships 4, no. 4 (2019): 1–14. http://dx.doi.org/10.4018/ijqspr.2019100101.

Full text

Abstract:

Enoyl-acyl carrier protein reductase (FabI) is a key enzyme in the fatty acid metabolism of gram-positive bacteria and is considered a potential target for new antibacterial drugs development. Indeed, triclosan is a widely employed antibacterial and AFN-1252 is currently under phase-II clinical trials, both are known as FabI inhibitors. Nowadays, there is an urgent need for new drug discovery due to increasing antibacterial resistance. In the present study, classification models using machine learning techniques were generated to distinguish SaFabI inhibitors from non-inhibitors successfully (

APA, Harvard, Vancouver, ISO, and other styles

48

Bibens, Laurie, Jean-Paul Becker, Alexandra Dassonville-Klimpt, and Pascal Sonnet. "A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs." Pharmaceuticals 16, no. 3 (2023): 425. http://dx.doi.org/10.3390/ph16030425.

Full text

Abstract:

Resistance to antimicrobial drugs is currently a serious threat to human health. Consequently, we are facing an urgent need for new antimicrobial drugs acting with original modes of action. The ubiquitous and widely conserved microbial fatty acid biosynthesis pathway, called FAS-II system, represents a potential target to tackle antimicrobial resistance. This pathway has been extensively studied, and eleven proteins have been described. FabI (or InhA, its homologue in mycobacteria) was considered as a prime target by many teams and is currently the only enzyme with commercial inhibitor drugs:

APA, Harvard, Vancouver, ISO, and other styles

49

Alajlani, Muaaz. "Biological activities of the traditional chinese medicine formula Fang Feng Tong Sheng San." Intrinsic Activity 4, Suppl. 3 (2016): A1.8. http://dx.doi.org/10.25006/ia.4.s3-a1.8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Alter, Blanche P., Bari J. Ballew, Neelam Giri, et al. "Novel Fanci Mutations in Fanconi Anemia with Vacterl Association." Blood 126, no. 23 (2015): 4780. http://dx.doi.org/10.1182/blood.v126.23.4780.4780.

Full text

Abstract:

Abstract Introduction: Fanconi anemia (FA) is associated with mutations in at least 18 genes in the FA/BRCA DNA repair pathway. Some patients with FA have features of the VACTERL association (vertebral anomalies, anal atresia, congenital heart disease, trachea-esophageal fistula, esophageal atresia, renal, and limb anomalies [radius and/or thumb]). Any three anomalies are required to be classified as VACTERL association. The presence of this association among cases with FA is considered to be 5%; the frequency of FA among those with VACTERL association is unknown. Objective: To determine the g

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!