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Journal articles on the topic 'Biology - Carbohydrate Functionalized Nanomaterials'

Author: Grafiati

Published: 7 September 2023

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1

Fakayode, Olayemi J., Ncediwe Tsolekile, Sandile P. Songca, and Oluwatobi S. Oluwafemi. "Applications of functionalized nanomaterials in photodynamic therapy." Biophysical Reviews 10, no. 1 (2018): 49–67. http://dx.doi.org/10.1007/s12551-017-0383-2.

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2

Guan, Guijian, and Ming‐Yong Han. "Functionalized Hybridization of 2D Nanomaterials." Advanced Science 6, no. 23 (2019): 1901837. http://dx.doi.org/10.1002/advs.201901837.

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3

Sharma, Horrick, and Somrita Mondal. "Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine." International Journal of Molecular Sciences 21, no. 17 (2020): 6280. http://dx.doi.org/10.3390/ijms21176280.

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The usage of nanomaterials for cancer treatment has been a popular research focus over the past decade. Nanomaterials, including polymeric nanomaterials, metal nanoparticles, semiconductor quantum dots, and carbon-based nanomaterials such as graphene oxide (GO), have been used for cancer cell imaging, chemotherapeutic drug targeting, chemotherapy, photothermal therapy, and photodynamic therapy. In this review, we discuss the concept of targeted nanoparticles in cancer therapy and summarize the in vivo biocompatibility of graphene-based nanomaterials. Specifically, we discuss in detail the chem

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Liu, Yangkun, Gongmeiyue Su, Ruoyao Zhang, Rongji Dai, and Zhao Li. "Nanomaterials-Functionalized Hydrogels for the Treatment of Cutaneous Wounds." International Journal of Molecular Sciences 24, no. 1 (2022): 336. http://dx.doi.org/10.3390/ijms24010336.

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Hydrogels have been utilized extensively in the field of cutaneous wound treatment. The introduction of nanomaterials (NMs), which are a big category of materials with diverse functionalities, can endow the hydrogels with additional and multiple functions to meet the demand for a comprehensive performance in wound dressings. Therefore, NMs-functionalized hydrogels (NMFHs) as wound dressings have drawn intensive attention recently. Herein, an overview of reports about NMFHs for the treatment of cutaneous wounds in the past five years is provided. Firstly, fabrication strategies, which are mainl

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5

Alshamrani, Meshal. "Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials." Polymers 14, no. 6 (2022): 1221. http://dx.doi.org/10.3390/polym14061221.

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Nanotechnology is an important branch of science in therapies known as “nanomedicine” and is the junction of various fields such as material science, chemistry, biology, physics, and optics. Nanomaterials are in the range between 1 and 100 nm in size and provide a large surface area to volume ratio; thus, they can be used for various diseases, including cardiovascular diseases, cancer, bacterial infections, and diabetes. Nanoparticles play a crucial role in therapy as they can enhance the accumulation and release of pharmacological agents, improve targeted delivery and ultimately decrease the

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Branderhorst, Hilbert M., Rob Ruijtenbeek, Rob M. J. Liskamp, and Roland J. Pieters. "Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip." ChemBioChem 9, no. 11 (2008): 1836–44. http://dx.doi.org/10.1002/cbic.200800195.

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7

Dutta, Sutapa, Stefano Corni, and Giorgia Brancolini. "Atomistic Simulations of Functionalized Nano-Materials for Biosensors Applications." International Journal of Molecular Sciences 23, no. 3 (2022): 1484. http://dx.doi.org/10.3390/ijms23031484.

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Nanoscale biosensors, a highly promising technique in clinical analysis, can provide sensitive yet label-free detection of biomolecules. The spatial and chemical specificity of the surface coverage, the proper immobilization of the bioreceptor as well as the underlying interfacial phenomena are crucial elements for optimizing the performance of a biosensor. Due to experimental limitations at the microscopic level, integrated cross-disciplinary approaches that combine in silico design with experimental measurements have the potential to present a powerful new paradigm that tackles the issue of

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Koukalová, Tereza, Petr Kovaříček, Pavla Bojarová, et al. "Reversible Lectin Binding to Glycan-Functionalized Graphene." International Journal of Molecular Sciences 22, no. 13 (2021): 6661. http://dx.doi.org/10.3390/ijms22136661.

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The monolayer character of two-dimensional materials predestines them for application as active layers of sensors. However, their inherent high sensitivity is always accompanied by a low selectivity. Chemical functionalization of two-dimensional materials has emerged as a promising way to overcome the selectivity issues. Here, we demonstrate efficient graphene functionalization with carbohydrate ligands—chitooligomers, which bind proteins of the lectin family with high selectivity. Successful grafting of a chitooligomer library was thoroughly characterized, and glycan binding to wheat germ agg

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David, Christopher A. W., Michael Barrow, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, and Neill J. Liptrott. "In Vitro Determination of the Immunogenic Impact of Nanomaterials on Primary Peripheral Blood Mononuclear Cells." International Journal of Molecular Sciences 21, no. 16 (2020): 5610. http://dx.doi.org/10.3390/ijms21165610.

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Investigation of the potential for nanomaterials to generate immunogenic effects is a key aspect of a robust preclinical evaluation. In combination with physicochemical characterization, such assessments also provide context for how material attributes influence biological outcomes. Furthermore, appropriate models for these assessments allow accurate in vitro to in vivo extrapolation, which is vital for the mechanistic understanding of nanomaterial action. Here we have assessed the immunogenic impact of a small panel of commercially available and in-house prepared nanomaterials on primary huma

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Vázquez-González, Margarita, and Itamar Willner. "Aptamer-Functionalized Hybrid Nanostructures for Sensing, Drug Delivery, Catalysis and Mechanical Applications." International Journal of Molecular Sciences 22, no. 4 (2021): 1803. http://dx.doi.org/10.3390/ijms22041803.

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Sequence-specific nucleic acids exhibiting selective recognition properties towards low-molecular-weight substrates and macromolecules (aptamers) find growing interest as functional biopolymers for analysis, medical applications such as imaging, drug delivery and even therapeutic agents, nanotechnology, material science and more. The present perspective article introduces a glossary of examples for diverse applications of aptamers mainly originated from our laboratory. These include the introduction of aptamer-functionalized nanomaterials such as graphene oxide, Ag nanoclusters and semiconduct

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11

Serrasqueiro, Filipa, Ana Isabel Barbosa, Sofia A. Costa Lima, and Salette Reis. "Targeting the Mannose Receptor with Functionalized Fucoidan/Chitosan Nanoparticles Triggers the Classical Activation of Macrophages." International Journal of Molecular Sciences 24, no. 12 (2023): 9908. http://dx.doi.org/10.3390/ijms24129908.

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Understanding how nanoparticles’ properties influence their cellular interactions is a bottleneck for improving the design of carriers. Macrophage polarization governs their active role in solving infections or tissue repair. To unravel the effect of carbohydrate-targeting mannose receptors on the macrophage surface, drug-free fucoidan/chitosan nanoparticles were functionalized using mannose (M) and mannan (Mn). Polyelectrolyte complex nanoparticles were obtained upon chitosan self-assembly using fucoidan. The functionalized nanoparticles were characterized in terms of their physicochemical ch

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Rotella, Madeline, Alicia Briegel, John Hull, Anthony Lagalante, and Robert Giuliano. "Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers." Journal of Nanomaterials 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/204961.

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Surface functionalization of nanomaterials is an area of current investigation that supports the development of new biomaterials for applications in biology and medicine. Herein we describe the synthesis, characterization, and antibacterial properties of the first examples of antibiotic-labeled graphitic carbon nanofibers (GCNFs) covalently functionalized with aminoglycoside and quinolone antibiotics. Ruthenium tetroxide oxidation of herringbone GCNFs gave higher amounts of surface carboxyl groups than previous methods. These carboxyl groups served as sites of attachment for antibiotics by acy

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Tam, Dick Yan, and Pik Kwan Lo. "Multifunctional DNA Nanomaterials for Biomedical Applications." Journal of Nanomaterials 2015 (2015): 1–21. http://dx.doi.org/10.1155/2015/765492.

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The rapidly emerging DNA nanotechnology began with pioneer Seeman’s hypothesis that DNA not only can carry genetic information but also can be used as molecular organizer to create well-designed and controllable nanomaterials for applications in materials science, nanotechnology, and biology. DNA-based self-assembly represents a versatile system for nanoscale construction due to the well-characterized conformation of DNA and its predictability in the formation of base pairs. The structural features of nucleic acids form the basis of constructing a wide variety of DNA nanoarchitectures with wel

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Zielińska, Daria, Andrzej Skrzypczak, Barbara Peplińska, and Sławomir Borysiak. "Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids." International Journal of Molecular Sciences 23, no. 24 (2022): 15807. http://dx.doi.org/10.3390/ijms232415807.

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The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials. This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity. Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer co

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Su, Chen, Kun Huang, Hao-Hong Li, You-Guang Lu, and Da-Li Zheng. "Antibacterial Properties of Functionalized Gold Nanoparticles and Their Application in Oral Biology." Journal of Nanomaterials 2020 (November 17, 2020): 1–13. http://dx.doi.org/10.1155/2020/5616379.

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As bacterial resistance is becoming increasingly serious, the development of antibacterial nanomaterials is an effective method of solving this problem. Gold nanoparticles have good stability and excellent biocompatibility and are easily modified, and their antibacterial properties can be enhanced by changing their structure and size or adding ingredients. Gold nanoparticles are also excellent drug carriers that can improve the antibacterial effects of loaded antibacterial drugs. After being modified and combined with other antibacterial drugs, gold nanoparticles can also play a better antibac

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Juárez-Maldonado, Antonio, Hortensia Ortega-Ortíz, América Berenice Morales-Díaz, et al. "Nanoparticles and Nanomaterials as Plant Biostimulants." International Journal of Molecular Sciences 20, no. 1 (2019): 162. http://dx.doi.org/10.3390/ijms20010162.

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Biostimulants are materials that when applied in small amounts are capable of promoting plant growth. Nanoparticles (NPs) and nanomaterials (NMs) can be considered as biostimulants since, in specific ranges of concentration, generally in small levels, they increase plant growth. Pristine NPs and NMs have a high density of surface charges capable of unspecific interactions with the surface charges of the cell walls and membranes of plant cells. In the same way, functionalized NPs and NMs, and the NPs and NMs with a corona formed after the exposition to natural fluids such as water, soil solutio

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Tupone, Maria Grazia, Gloria Panella, Michele d’Angelo, et al. "An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration." International Journal of Molecular Sciences 22, no. 23 (2021): 13047. http://dx.doi.org/10.3390/ijms222313047.

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Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity,

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Dash, Banendu Sunder, Gils Jose, Yu-Jen Lu, and Jyh-Ping Chen. "Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy." International Journal of Molecular Sciences 22, no. 6 (2021): 2989. http://dx.doi.org/10.3390/ijms22062989.

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Cancer is one of the deadliest diseases in human history with extremely poor prognosis. Although many traditional therapeutic modalities—such as surgery, chemotherapy, and radiation therapy—have proved to be successful in inhibiting the growth of tumor cells, their side effects may vastly limited the actual benefits and patient acceptance. In this context, a nanomedicine approach for cancer therapy using functionalized nanomaterial has been gaining ground recently. Considering the ability to carry various anticancer drugs and to act as a photothermal agent, the use of carbon-based nanomaterial

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Borghi, F. F., A. E. Rider, S. Kumar, Z. J. Han, D. Haylock, and K. Ostrikov. "Emerging Stem Cell Controls: Nanomaterials and Plasma Effects." Journal of Nanomaterials 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/329139.

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Stem cells (SC) are among the most promising cell sources for tissue engineering due to their ability to self-renew and differentiate, properties that underpin their clinical application in tissue regeneration. As such, control of SC fate is one of the most crucial issues that needs to be fully understood to realise their tremendous potential in regenerative biology. The use of functionalized nanostructured materials (NM) to control the microscale regulation of SC has offered a number of new features and opportunities for regulating SC. However, fabricating and modifying such NM to induce spec

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مريم خويطر. "Review: Electrochemical biosensors based on ZnO nanostructures." Journal of Pure & Applied Sciences 22, no. 1 (2023): 22–40. http://dx.doi.org/10.51984/jopas.v22i1.1456.

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In the last few decades’ electrochemical biosensors have witnessed vast developments due to the broad range of different applications, including health care and medical diagnosis, environmental monitoring and assessment, food industry, and drug delivery. Integration of nanostructured material with different disciplines and expertise of electrochemistry, solid-state physics, material science, and biology has offered the opportunity of a future generation of highly rapid, sensitive, stable, selective, and novel electrochemical biosensor devices. Among metal oxide nanomaterials, ZnO nanostructure

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21

Chu, Pat PY, Sudipto Bari, Leong U. Ling, et al. "Functionalized Carbon Nanotubes Increase the Viability of Post-Thaw Cord Blood Cells and Enhance the Overall Hematopoietic Progenitor Cell Expansion in Ex Vivo Culture." Blood 118, no. 21 (2011): 1327. http://dx.doi.org/10.1182/blood.v118.21.1327.1327.

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Abstract Abstract 1327 The clinical application of cord blood (CB) cells for transplantation is often hampered by the low cell number and viability from frozen cell sources. This problem could be partly resolved by ex vivo expansion and the improvement of CB viability through the use of a mesenchymal feeder cell layer or an appropriately designed material scaffold. Carbon-based nanomaterials have gained immense attention in biomedical applications in recent years, owing to their unique physicochemical characteristics. These novel materials have been applied as scaffolds in tissue engineering t

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Toma, Francesca Maria, Andrea Sartorel, Mauro Carraro, Marcella Bonchio, and Maurizio Prato. "Dendron-functionalized multiwalled carbon nanotubes incorporating polyoxometalates for water-splitting catalysis." Pure and Applied Chemistry 83, no. 8 (2011): 1529–42. http://dx.doi.org/10.1351/pac-con-10-11-12.

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Carbon nanotubes (CNTs) are versatile nanomaterials with applications spanning from medicinal chemistry and biology, to electronics as field effect transistors or energy as fuel cells. The major drawback stems from the CNT insolubility in most of the organic and aqueous media, which severely hampers the material processability. To overcome this problem, functionalization of CNTs is generally accomplished by either covalent strategies resulting in the modification of the CNT backbone via radical reactions, fluorination, and/or cycloaddition reactions, or noncovalent protocols, exploiting multip

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Kuo, Wen-Shuo, Chia-Yuan Chang, Keng-Shiang Huang, et al. "Amino-Functionalized Nitrogen-Doped Graphene-Quantum-Dot-Based Nanomaterials with Nitrogen and Amino-Functionalized Group Content Dependence for Highly Efficient Two-Photon Bioimaging." International Journal of Molecular Sciences 21, no. 8 (2020): 2939. http://dx.doi.org/10.3390/ijms21082939.

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We fabricated nanomaterials comprising amino-functionalized and nitrogen-doped graphene quantum dots (amino-N-GQDs) and investigated their photostability and intrinsic luminescence in the near-infrared spectrum to determine their suitability as contrast agents in two-photon imaging (TPI). We observed that amino-N-GQDs with a higher amount of bonded nitrogen and amino-functionalized groups (6.2%) exhibited superior two-photon properties to those with a lower amount of such nitrogen and groups (4.9%). These materials were conjugated with polymers containing sulfur (polystyrene sulfonate, PSS) an

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Della Camera, Giacomo, Dorelia Lipsa, Dora Mehn, Paola Italiani, Diana Boraschi, and Sabrina Gioria. "A Step-by-Step Approach to Improve Clinical Translation of Liposome-Based Nanomaterials, a Focus on Innate Immune and Inflammatory Responses." International Journal of Molecular Sciences 22, no. 2 (2021): 820. http://dx.doi.org/10.3390/ijms22020820.

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This study aims to provide guidelines to design and perform a robust and reliable physical-chemical characterization of liposome-based nanomaterials, and to support method development with a specific focus on their inflammation-inducing potential. Out of eight differently functionalized liposomes selected as “case-studies”, three passed the physical-chemical characterization (in terms of size-distribution, homogeneity and stability) and the screening for bacterial contamination (sterility and apyrogenicity). Although all three were non-cytotoxic when tested in vitro, they showed a different ca

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Silveri, Filippo, Flavio Della Pelle, Annalisa Scroccarello, et al. "Carbon Black Functionalized with Naturally Occurring Compounds in Water Phase for Electrochemical Sensing of Antioxidant Compounds." Antioxidants 11, no. 10 (2022): 2008. http://dx.doi.org/10.3390/antiox11102008.

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A new sustainable route to nanodispersed and functionalized carbon black in water phase (W-CB) is proposed. The sonochemical strategy exploits ultrasounds to disaggregate the CB, while two selected functional naturally derived compounds, sodium cholate (SC) and rosmarinic acid (RA), act as stabilizing agents ensuring dispersibility in water adhering onto the CB nanoparticles’ surface. Strategically, the CB-RA compound is used to drive the AuNPs self-assembling at room temperature, resulting in a CB surface that is nanodecorated; further, this is achieved without the need for additional reagent

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Nica, Ionela Cristina, Miruna S. Stan, Roua G. Popescu, et al. "Fe-N Co-Doped Titanium Dioxide Nanoparticles Induce Cell Death in Human Lung Fibroblasts in a p53-Independent Manner." International Journal of Molecular Sciences 22, no. 17 (2021): 9627. http://dx.doi.org/10.3390/ijms22179627.

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The advancement of nanotechnology in the last decade has developed an abundance of novel and intriguing TiO2-based nanomaterials that are widely used in many sectors, including industry (as a food additive and colorant in cosmetics, paints, plastics, and toothpaste) and biomedicine (photoelectrochemical biosensing, implant coatings, drug delivery, and new emerging antimicrobial agents). Therefore, the increased use of engineered nanomaterials in the industry has raised serious concern about human exposure and their unexpected cytotoxic effects. Since inhalation is considered the most relevant

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Zhao, C. H., X. P. Zhang, and L. Zhang. "RGD peptide functionalized graphene oxide: a bioactive surface for cell-material interactions." Digest Journal of Nanomaterials and Biostructures 17, no. 3 (2022): 989–97. http://dx.doi.org/10.15251/djnb.2022.173.989.

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Recently, functionalized graphene-based nanomaterials have gained tremendous attention in biomedical field owing to their biocompatibility, surface functionalizability and their unique mechanical, electronic, and optical properties. Herein, we report a facile one step modification of graphene oxide by RGD peptide, which is known to improve the tissue– material contact by highly specific binding to cellular membrane receptors known as integrins. A detailed structural and morphological characterization of the obtained RGD functionalized graphene oxide (GO-RGD) was performed. The synthesized bioa

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Nourafkan, E., Z. Hu, M. Garum, H. Esmaeili, and D. Wen. "Nanomaterials for subsurface application: study of particles retention in porous media." Applied Nanoscience 11, no. 6 (2021): 1847–56. http://dx.doi.org/10.1007/s13204-021-01843-2.

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AbstractThe ability to transport nanoparticles through porous media has interesting engineering applications, notably in reservoir capacity exploration and soil remediation. A series of core-flooding experiments were conducted for quantitative analysis of functionalized TiO2 nanoparticles transport through various porous media including calcite, dolomite, silica, and limestone rocks. The adsorption of surfactants on the rock surface and nanoparticle retention in pore walls were evaluated by chemical oxygen demand (COD) and UV–Vis spectroscopy. By applying TiO2 nanoparticles, 49.3 and 68.0 wt.%

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Tomaszewska, Emilia, Katarzyna Ranoszek-Soliwoda, Katarzyna Bednarczyk, et al. "Anti-HSV Activity of Metallic Nanoparticles Functionalized with Sulfonates vs. Polyphenols." International Journal of Molecular Sciences 23, no. 21 (2022): 13104. http://dx.doi.org/10.3390/ijms232113104.

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Metallic nanoparticles exhibit broad-spectrum activity against bacteria, fungi, and viruses. The antiviral activity of nanoparticles results from the multivalent interactions of nanoparticles with viral surface components, which result from the nanometer size of the material and the presence of functional compounds adsorbed on the nanomaterial surface. A critical step in the virus infection process is docking and entry of the virus into the host cell. This stage of the infection can be influenced by functional nanomaterials that exhibit high affinity to the virus surface and hence can disrupt

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Kędzierska, Marta, Nisrine Hammi, Joanna Kolodziejczyk-Czepas, et al. "Glassy-like Metal Oxide Particles Embedded on Micrometer Thicker Alginate Films as Promising Wound Healing Nanomaterials." International Journal of Molecular Sciences 23, no. 10 (2022): 5585. http://dx.doi.org/10.3390/ijms23105585.

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Micrometer-thicker, biologically responsive nanocomposite films were prepared starting from alginate-metal alkoxide colloidal solution followed by sol-gel chemistry and solvent removal through evaporation-induced assembly. The disclosed approach is straightforward and highly versatile, allowing the entrapment and growth of a set of glassy-like metal oxide within the network of alginate and their shaping as crake-free transparent and flexible films. Immersing these films in aqueous medium triggers alginate solubilization, and affords water-soluble metal oxides wrapped in a biocompatible carbohy

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González-Fernández, Carmen, Francisco Guillermo Díaz Baños, María Ángeles Esteban, and Alberto Cuesta. "Functionalized Nanoplastics (NPs) Increase the Toxicity of Metals in Fish Cell Lines." International Journal of Molecular Sciences 22, no. 13 (2021): 7141. http://dx.doi.org/10.3390/ijms22137141.

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Nanoplastics (NPs) are one of the most abundant environment-threatening nanomaterials on the market. The objective of this study was to determine in vitro if functionalized NPs are cytotoxic by themselves or increase the toxicity of metals. For that, we used 50 nm polystyrene nanoparticles with distinct surface functionalization (pristine, PS-Plain; carboxylic, PS-COOH; and amino PS-NH2) alone or combined with the metals arsenic (As) and methylmercury (MeHg), which possess an environmental risk to marine life. As test model, we chose a brain-derived cell line (SaB-1) from gilthead seabream (Sp

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Tripathi, Manoj, Luca Valentini, Yuanyang Rong, et al. "Free-Standing Graphene Oxide and Carbon Nanotube Hybrid Papers with Enhanced Electrical and Mechanical Performance and Their Synergy in Polymer Laminates." International Journal of Molecular Sciences 21, no. 22 (2020): 8585. http://dx.doi.org/10.3390/ijms21228585.

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Hybrid nanomaterials fabricated by the heterogeneous integration of 1D (carbon nanotubes) and 2D (graphene oxide) nanomaterials showed synergy in electrical and mechanical properties. Here, we reported the infiltration of carboxylic functionalized single-walled carbon nanotubes (C-SWNT) into free-standing graphene oxide (GO) paper for better electrical and mechanical properties than native GO. The stacking arrangement of GO sheets and its alteration in the presence of C-SWNT were comprehensively explored through scanning electron microscopy, X-ray photoelectron spectroscopy (XPS) and X-ray dif

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Wu, Yongyan, Yufeng Qian, Wei Peng, and Xuchen Qi. "Functionalized nanoparticles crossing the brain–blood barrier to target glioma cells." PeerJ 11 (July 4, 2023): e15571. http://dx.doi.org/10.7717/peerj.15571.

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Glioma is the most common tumor of the central nervous system (CNS), with a 5-year survival rate of <35%. Drug therapy, such as chemotherapeutic and immunotherapeutic agents, remains one of the main treatment modalities for glioma, including temozolomide, doxorubicin, bortezomib, cabazitaxel, dihydroartemisinin, immune checkpoint inhibitors, as well as other approaches such as siRNA, ferroptosis induction, etc. However, the filter function of the blood-brain barrier (BBB) reduces the amount of drugs needed to effectively target CNS tumors, making it one of the main reasons for poor drug eff

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Zheng, Haifu, and Xuezhong Du. "Multivalent protein binding in carbohydrate-functionalized monolayers through protein-directed rearrangement and reorientation of glycolipids at the air–water interface." Biochimica et Biophysica Acta (BBA) - Biomembranes 1808, no. 9 (2011): 2128–35. http://dx.doi.org/10.1016/j.bbamem.2011.04.019.

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Shan, Suyan, Shujuan Jia, Tom Lawson, Lu Yan, Mimi Lin, and Yong Liu. "The Use of TAT Peptide-Functionalized Graphene as a Highly Nuclear-Targeting Carrier System for Suppression of Choroidal Melanoma." International Journal of Molecular Sciences 20, no. 18 (2019): 4454. http://dx.doi.org/10.3390/ijms20184454.

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Tumorous metastasis is a difficult challenge to resolve for researchers and for clinicians. Targeted delivery of antitumor drugs towards tumor cells’ nuclei can be a practical approach to resolving this issue. This work describes an efficient nuclear-targeting delivery system prepared from trans-activating transcriptional activator (TAT) peptide-functionalized graphene nanocarriers. The TAT peptide, originally observed in a human immunodeficiency virus 1 (HIV-1), was incorporated with graphene via an edge-functionalized ball-milling method developed by the author’s research group. High tumor-t

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Endo, Masayuki, and Hiroshi Sugiyama. "DNA Origami Nanomachines." Molecules 23, no. 7 (2018): 1766. http://dx.doi.org/10.3390/molecules23071766.

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DNA can assemble various molecules and nanomaterials in a programmed fashion and is a powerful tool in the nanotechnology and biology research fields. DNA also allows the construction of desired nanoscale structures via the design of DNA sequences. Structural nanotechnology, especially DNA origami, is widely used to design and create functionalized nanostructures and devices. In addition, DNA molecular machines have been created and are operated by specific DNA strands and external stimuli to perform linear, rotational, and reciprocating movements. Furthermore, complicated molecular systems ha

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Rezayi, Majid, Pegah Mahmoodi, Hadis Langari, Behzad Behnam, and Amirhossein Sahebkar. "Conjugates of Curcumin with Graphene and Carbon Nanotubes: A Review on Biomedical Applications." Current Medicinal Chemistry 27, no. 40 (2020): 6849–63. http://dx.doi.org/10.2174/0929867326666191113145745.

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In the last decade, the use of carbon nanotubes and graphenes has been on the rise for various nanobiotechnological applications. Owing to their special characteristics, these two nanostructures of carbon allotropes have been studied for their capacity in the detection and treatment of many diseases. On the other hand, curcumin, a well-known antioxidant and anticancer natural product, is being extensively studied for numerous medicinal applications. Interestingly, many reports have shown great potentials of conjugates of curcumin and carbon nanotubes or graphenes. These conjugates, when proper

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Farhana, Aisha. "Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects." International Journal of Molecular Sciences 24, no. 4 (2023): 3493. http://dx.doi.org/10.3390/ijms24043493.

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Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a con

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Kędzierska, Marta, Sara Blilid, Katarzyna Miłowska, et al. "Insight into Factors Influencing Wound Healing Using Phosphorylated Cellulose-Filled-Chitosan Nanocomposite Films." International Journal of Molecular Sciences 22, no. 21 (2021): 11386. http://dx.doi.org/10.3390/ijms222111386.

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Marine polysaccharides are believed to be promising wound-dressing nanomaterials because of their biocompatibility, antibacterial and hemostatic activity, and ability to easily shape into transparent films, hydrogels, and porous foams that can provide a moist micro-environment and adsorb exudates. Current efforts are firmly focused on the preparation of novel polysaccharide-derived nanomaterials functionalized with chemical objects to meet the mechanical and biological requirements of ideal wound healing systems. In this contribution, we investigated the characteristics of six different cellul

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Carpita, Nicholas C., and Maureen C. McCann. "Redesigning plant cell walls for the biomass-based bioeconomy." Journal of Biological Chemistry 295, no. 44 (2020): 15144–57. http://dx.doi.org/10.1074/jbc.rev120.014561.

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Lignocellulosic biomass—the lignin, cellulose, and hemicellulose that comprise major components of the plant cell well—is a sustainable resource that could be utilized in the United States to displace oil consumption from heavy vehicles, planes, and marine-going vessels and commodity chemicals. Biomass-derived sugars can also be supplied for microbial fermentative processing to fuels and chemicals or chemically deoxygenated to hydrocarbons. However, the economic value of biomass might be amplified by diversifying the range of target products that are synthesized in living plants. Genetic engin

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Mitrofanova, I. V., I. V. Milto, I. V. Suhodolo, and G. Yu Vasyukov. "OPPORTUNITIES OF BIOMEDICAL USE OF CARBON NANOTUBES." Bulletin of Siberian Medicine 13, no. 1 (2014): 135–44. http://dx.doi.org/10.20538/1682-0363-2014-1-135-144.

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Nanomaterials – materials, whouse structure elements has proportions doesn’t exceed 100 nm. In superdispersed state matter acquire new properties. In the last decade, carbon nanotubes become the most popular nanomaterials, that cause attention of representatives of various scientific field. The сarbon nanotubes offer new opportunities for biological and medical applications: imaging at the molecular, cellular and tissue levels, biosensors and electrodes based on carbon nanotubes, target delivery of various substances, radiation and photothermal therapy. The most promising of carbon nanotubes i

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Grilli, Francesca, Parisa Hajimohammadi Gohari, and Shan Zou. "Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells." International Journal of Molecular Sciences 23, no. 12 (2022): 6802. http://dx.doi.org/10.3390/ijms23126802.

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Functionalized graphene oxide (GO) nanoparticles are being increasingly employed for designing modern drug delivery systems because of their high degree of functionalization, high surface area with exceptional loading capacity, and tunable dimensions. With intelligent controlled release and gene silencing capability, GO is an effective nanocarrier that permits the targeted delivery of small drug molecules, antibodies, nucleic acids, and peptides to the liquid or solid tumor sites. However, the toxicity and biocompatibility of GO-based formulations should be evaluated, as these nanomaterials ma

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Iłowska, Emilia, Jakub Barciszewski, Mariusz Jaskólski, Augustyn Moliński, Maciej Kozak, and Aneta Szymańska. "Identification of a Steric Zipper Motif in the Amyloidogenic Core of Human Cystatin C and Its Use for the Design of Self-Assembling Peptides." International Journal of Molecular Sciences 23, no. 10 (2022): 5800. http://dx.doi.org/10.3390/ijms23105800.

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Amyloid fibrils have been known for many years. Unfortunately, their fame stems from negative aspects related to amyloid diseases. Nevertheless, due to their properties, they can be used as interesting nanomaterials. Apart from their remarkable stability, amyloid fibrils may be regarded as a kind of a storage medium and as a source of active peptides. In many cases, their structure may guarantee a controlled and slow release of peptides in their active form; therefore, they can be used as a potential nanomaterial in drug delivery systems. In addition, amyloid fibrils display controllable stiff

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Conte, Raffaele, Anna Valentino, Francesca Di Cristo, et al. "Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells." International Journal of Molecular Sciences 21, no. 3 (2020): 869. http://dx.doi.org/10.3390/ijms21030869.

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MicroRNAs (miRNAs) play a pivotal role in regulating the expression of genes involved in tumor development, invasion, and metastasis. In particular, microRNA-124 (miR-124) modulates the expression of carnitine palmitoyltransferase 1A (CPT1A) at the post-transcriptional level, impairing the ability of androgen-independent prostate cancer (PC3) cells to completely metabolize lipid substrates. However, the clinical translation of miRNAs requires the development of effective and safe delivery systems able to protect nucleic acids from degradation. Herein, biodegradable polyethyleneimine-functional

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Lee, Jaewook, Ji-Heon Lee, Jagannath Mondal, et al. "Magnetofluoro-Immunosensing Platform Based on Binary Nanoparticle-Decorated Graphene for Detection of Cancer Cell-Derived Exosomes." International Journal of Molecular Sciences 23, no. 17 (2022): 9619. http://dx.doi.org/10.3390/ijms23179619.

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Multi-functionalized carbon nanomaterials have attracted interest owing to their excellent synergic properties, such as plasmon resonance energy transfer and surface-enhanced Raman scattering. Particularly, nanoparticle (NP)-decorated graphene (GRP) has been applied in various fields. In this study, silver NP (AgNP)- and magnetic iron oxide NP (IONP)-decorated GRP were prepared and utilized as biosensing platforms. In this case, AgNPs and GRP exhibit plasmonic properties, whereas IONPs exhibit magnetic properties; therefore, this hybrid nanomaterial could function as a magnetoplasmonic substra

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Aasi, Aref, Sadegh Aghaei, Matthew Moore, and Balaji Panchapakesan. "Pt-, Rh-, Ru-, and Cu-Single-Wall Carbon Nanotubes Are Exceptional Candidates for Design of Anti-Viral Surfaces: A Theoretical Study." International Journal of Molecular Sciences 21, no. 15 (2020): 5211. http://dx.doi.org/10.3390/ijms21155211.

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As SARS-CoV-2 is spreading rapidly around the globe, adopting proper actions for confronting and protecting against this virus is an essential and unmet task. Reactive oxygen species (ROS) promoting molecules such as peroxides are detrimental to many viruses, including coronaviruses. In this paper, metal decorated single-wall carbon nanotubes (SWCNTs) were evaluated for hydrogen peroxide (H2O2) adsorption for potential use for designing viral inactivation surfaces. We employed first-principles methods based on the density functional theory (DFT) to investigate the capture of an individual H2O2

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Shin, Kyujin, Yo Song, Yeongchang Goh, and Kang Lee. "Two-Dimensional and Three-Dimensional Single Particle Tracking of Upconverting Nanoparticles in Living Cells." International Journal of Molecular Sciences 20, no. 6 (2019): 1424. http://dx.doi.org/10.3390/ijms20061424.

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Lanthanide-doped upconversion nanoparticles (UCNPs) are inorganic nanomaterials in which the lanthanide cations embedded in the host matrix can convert incident near-infrared light to visible or ultraviolet light. These particles are often used for long-term and real-time imaging because they are extremely stable even when subjected to continuous irradiation for a long time. It is now possible to image their movement at the single particle level with a scale of a few nanometers and track their trajectories as a function of time with a scale of a few microseconds. Such UCNP-based single-particl

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Bai, Ding-Ping, Xin-Yu Lin, Yi-Fan Huang, and Xi-Feng Zhang. "Theranostics Aspects of Various Nanoparticles in Veterinary Medicine." International Journal of Molecular Sciences 19, no. 11 (2018): 3299. http://dx.doi.org/10.3390/ijms19113299.

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Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rodents extensively, still either studies or applications in veterinary medicine is not up to the level when compared to applications to human beings. The application in veterinary medicine and animal production is still relatively innovative. Recently, in the era of health care tech

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Mavridi-Printezi, Alexandra, Arianna Menichetti, Dario Mordini, and Marco Montalti. "Functionalization of and through Melanin: Strategies and Bio-Applications." International Journal of Molecular Sciences 24, no. 11 (2023): 9689. http://dx.doi.org/10.3390/ijms24119689.

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A unique feature of nanoparticles for bio-application is the ease of achieving multi-functionality through covalent and non-covalent functionalization. In this way, multiple therapeutic actions, including chemical, photothermal and photodynamic activity, can be combined with different bio-imaging modalities, such as magnetic resonance, photoacoustic, and fluorescence imaging, in a theragnostic approach. In this context, melanin-related nanomaterials possess unique features since they are intrinsically biocompatible and, due to their optical and electronic properties, are themselves very effici

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Zhang, Liangfang. "Nanoparticles Mimicking Platelets and Platelet Cloaking." Blood 134, Supplement_1 (2019): SCI—38—SCI—38. http://dx.doi.org/10.1182/blood-2019-121082.

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The diverse functions played by platelets such as immune evasion, subendothelium adhesion, and pathogen interactions hinge on unique surface moieties presented on the platelet membrane. This has inspired our recent development of platelet-mimicking nanoparticles by collecting and translocating human platelet membrane onto the surface of synthetic nanoparticles. The resulting platelet-like nanoparticles (denoted 'PNPs') possess a right-side-out unilamellar membrane coating functionalized with immunomodulatory and adhesion antigens associated with platelets. The PNPs faithfully present the entir

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