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Dissertations / Theses on the topic 'Biomarker panels'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Singh, Amritpal. "Blood biomarker panels of the late phase asthmatic response." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58777.

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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.<br>Medicine, Faculty of<br>Experimental Medicine, Division of<br>Medicine, Department of<br>Graduate

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2

Hupf, Julian Johannes Magnus [Verfasser], and Carsten [Akademischer Betreuer] Jungbauer. "Evaluation eines innovativen Biomarker-Panels bei Patienten mit akutem Brustschmerz / Julian Johannes Magnus Hupf ; Betreuer: Carsten Jungbauer." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1176808761/34.

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3

Pujade, Laura. "Development of a biomarker panel for identifying stressed marine mammals." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3587.

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Increasing anthropogenic disturbance in marine ecosystems such as fishing, oil-drilling, and noise pollution can have detrimental effects on the reproduction and survival of apex predators such as marine mammals. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, resulting in increased circulating glucocorticoid (GCs) hormones, which alter expression of target genes encoding metabolic enzymes and other mediators of stress. Prolonged HPA axis stimulation may increase catabolism of nutrient stores and suppress immune and reproductive functions, impacting the fitness of marine mammal

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4

Zhang, Xi. "The development and validation of a salivary protein panel to diagnose heart failure." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122851/2/Xi_Zhang_Thesis.pdf.

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Heart failure (HF) is a severe complication that affects 26 million people world-wide the lack of early screening programs in HF hinders early detection and targeted treatment and hence contributes greatly to the deaths associated with HF. By using human saliva as an alternative medium, a multi-protein biomarker panel were discovered using Sequential Window Acquisition of All Theoretical fragment ion spectra – Mass Spectrometry (SWATHMS). This panel was further validated and demonstrated excellent diagnostic performance with an overall accuracy of 84%. The finding in this thesis has the potent

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5

Smith, Eve Mary Dorothy. "Developing a lupus nephritis urinary biomarker panel in children for use in a clinical trial." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3003957/.

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Background: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare, severe multisystem autoimmune disease affecting the kidney (Lupus Nephritis, LN) in up to 80% of children. Numerous individual urinary biomarkers have previously been investigated. No individual biomarker has achieved ‘excellence’ in differentiating active from inactive LN. Aims: (1) To assess performance of traditional clinical biomarkers for LN monitoring and prediction of LN outcomes. (2) To select biomarkers warranting assessment in a ‘LN biomarker panel’; to cross-sectionally assess if combining novel/traditional bi

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6

Qureshi, Ayesha. "Assessment of a novel biomarker panel for the earlier prediction of acute kidney injury in patients with diabetes mellitus undergoing coronary angiography and intervention." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2530.

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Diabetes mellitus triples the risk of developing coronary heart disease (CHD). The manifestations of CHD are more severe in patients with diabetes with both more extensive and more diffuse disease. Outcomes in patients with diabetes are significantly worse both in terms of Major Adverse Cardiovascular Events (MACE) overall and specifically following revascularisation procedures such as percutaneous coronary intervention (PCI). Furthermore patients with chronic kidney disease (CKD) are excluded from the vast majority of cardiology trials and therefore there is a lack of data for these patients.

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7

Pechańska, Paulina [Verfasser], Peter-Michael Akademischer Betreuer] Kloetzel, Uwe [Akademischer Betreuer] Ohler, and André [Akademischer Betreuer] [Rosenthal. "A novel approach to develop predictive biomarkers : prediction of response to anti-EGFR therapy in a large panel of patient-derived colorectal cancer xenograft models / Paulina Pechanska. Gutachter: Peter-Michael Kloetzel ; Uwe Ohler ; André Rosenthal." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://d-nb.info/1051848350/34.

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8

Beaudoux, Olivia. "Caractérisation anatomo-clinique et moléculaire du mélanome primitif muqueux Prognostic factors and incidence of primary mucosal melanoma: a population-based study in France Massively invasive orbital melanoma: Uveal or conjunctival origin? “Response to imatinib of a patient with double-mutant KIT metastatic penile melanoma." Thesis, Reims, 2020. http://www.theses.fr/2020REIMM201.

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Le mélanome (M) primitif muqueux (MM) est une tumeur maligne rare et grave, comprenant les M buccaux et nasopharyngés, vulvovaginaux, conjonctivaux, anorectaux et péniens (MP). Les oncogènes impliqués sont largement inconnus. Les cas non résécables et métastatiques sont peu sensibles aux traitements actuels, thérapies ciblées et immunothérapies. Afin de mieux caractériser ces cancers orphelins, nous avons: (1) étudié, sur la base des cas incidents de Champagne-Ardenne entre 2004 et 2014 (n=39), l'incidence annuelle (0,18/100000) et le ratio d'incidence MM/M cutané (1/50), la fréquence relative

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9

Jäger, Jochen [Verfasser]. "Deriving small diagnostic biomarker panels from genome wide, clinical microarray studies / Jochen Jäger." 2006. http://d-nb.info/981806643/34.

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10

Martin, Karina. "Utilising quantitative immunoproteomics to reveal differential autoantibody biomarker panels in serous ovarian cancer patients." Thesis, 2015. http://hdl.handle.net/2440/98148.

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Epithelial ovarian cancer accounts for 5% of all cancer deaths and greater than 50% of all gynaecological cancer deaths. It presents at a late clinical stage in more than 60% of patients, and is associated with a 5-year survival of only 30% in this group. In contrast, the 5-year survival for patients with organ-confined stage I ovarian cancer exceeds 90%, and most patients are cured of their disease. Thus, the detection of early stage ovarian cancer is the best way to improve survival. No clinically applicable method exists for the early detection of ovarian cancer. Hence, there is an unmet me

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11

Chiung-Ling and 廖瓊玲. "Application of Various Biomarkers and Their Panels in Distinguishing from Endocervical and Endometrial Adenocarcinomas." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/43500241675886899414.

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博士<br>中山醫學大學<br>醫學研究所<br>99<br>Objective: The choice of appropriate therapeutic plans for primary endocervical adenocarcinomas (ECA) and endometrial adenocarcinomas (EMA) depends on the tumor’s site of origin, because they have differing biological behaviors. Although careful morphologic examination usually results in a confident diagnosis, difficulties may also arise in the pathological examination of a large surgically resected specimen for a tumor that involves both the lower uterine segment and upper endocervix. When there is doubt and indistinguishable primaries, immunohistochemistry (IHC

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12

Lee, Che Jui, and 李哲睿. "Panel miRNAs in saliva as early detection biomarkers for oral cancer." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/z9xag8.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>102<br>Oral cancer is one of the most common malignance in the world, yet, it is short of useful tumor marker for clinical application. MicroRNAs (miRNAs) which have been reported participating in various cancer pathogenesis are stable and detectable in circulating compartment, further reveal their biomarker potential. Previously, our laboratory has determined specific miRNA profile associated with oral cancer. In this study, we selected 5 candidates to examine their potential of being oral cancer biomarkers in saliva of mouthwash, the non-invasive and easily obtai

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13

Chan, Alison Hui-Wai. "Validation of Candidate Biomarkers for the Development of a Multi-Parametric Panel for Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC)." Thesis, 2013. http://hdl.handle.net/1807/42707.

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High-throughput mass spectrometry has discovered a plethora of candidates in the biomarker field, however, subsequent verification and validation studies are urgently needed to assess the potential of novel biomarkers in the detection of pancreatic cancer. We have conducted extensive verification and validation studies on two of our most promising biomarkers CUZD1 and LAMC2 with a total of 715 blood samples. In our study, both markers demonstrated consistent diagnostic ability of early- and CA19.9 negative-PDAC cases. When used in combination with CA19.9, CUZD1 and LAMC2 were shown to signific

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14

Chen, Yun Ju, and 陳芸如. "Develop an in vitro immune-based diagnosis using a panel of multiple biomarkers for colorectal cancer detection." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/67251614751104103067.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>99<br>Colorectal cancer (CRC) has become the third leading cause of death since 1994. This study used proteomics technologies to find candidate proteins and observed their expression in both the tumor and normal tissues. Based on that observation, we discovered several proteins that are potential biomarkers. This study successful cloned the RPL36 and discussed it along with the previous targets including RPH3AL, SLP2, p53, survivin, ANXA4 and SEC61B. Firstly, we used western blot to detect RPL36 autoantibody and found a significant difference between CRC patients a

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15

Deng, Yu Ming, and 鄧育旻. "Development of a novel protein biomarker panel for lung cancer by integration of cancer cell secretome & pleural effusion proteome." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/01064472826294349514.

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碩士<br>長庚大學<br>生物醫學研究所<br>98<br>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, which is one of the most prominent causes of cancer-related mortality in Taiwan (17.5%). In this study, we integrate two adenocarcinoma cancer cell lines secretome, CL1-0, CL1-5 and human pleural effusion proteome from lung adenocarcinoma patients to discover serum/pleural effusion maker panel for NSCLC. Previously, we have generated two of lung adenocarcinoma cell lines secretome databases and one pleural effusion proteome database by one-dimensional gel electrophoresis in conjunction wi

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16

GAJOFATTO, Alberto. "An exploratory panel of cerebrospinal fluid biomarkers compared to standard diagnostic evaluation in initial demyelinating events suggestive of multiple sclerosis." Doctoral thesis, 2012. http://hdl.handle.net/11562/400135.

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Premessa: La diagnosi e il profilo prognostico di un primo evento demielinizzante (ED) del sistema nervoso centrale non sono di immediata definizione. La diagnosi di sclerosi multipla e di altre possibili eziologie è basata su una combinazione di criteri che spesso richiedono un lungo monitoraggio per essere soddisfatti, dal momento che singoli test con elevata sensibilità e specificità al momento dell’evento iniziale sono limitati. I fattori predittivi di attività di malattia e disabilità dopo un primo ED sono conosciuti solo in parte. Scopo dello studio: Indagare il valore di tau, proteina

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17

Reis, Sara Raquel Monteiro dos. "The Role of a Panel of Three Epigenetic Biomarkers in the Detection and Prognosis of Upper Urinary Tract Urothelial Carcinoma." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/70609.

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18

Reis, Sara Raquel Monteiro dos. "The Role of a Panel of Three Epigenetic Biomarkers in the Detection and Prognosis of Upper Urinary Tract Urothelial Carcinoma." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/70609.

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