Relevant bibliographies by topics / Biomaterials

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Biomaterials'

Author: Grafiati
Published: 4 June 2021
Last updated: 24 March 2025

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Journal articles on the topic "Biomaterials"

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Ujjawal, Deepa, and Vikas Pruthi. "D-2 STUDY OF BIOFILM FORMATION ON BIOMATERIAL SURFACES(Session: Biomaterials)." Proceedings of the Asian Symposium on Materials and Processing 2006 (2006): 71. http://dx.doi.org/10.1299/jsmeasmp.2006.71.

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Macedo Iunes Carrera, Thaisa, Lélio Fernando Ferreira Soares, Suzane Cristina Pigossi, and Priscilla Barbosa Ferreira Soares. "Assessment of knowledge of biomaterial used in periodontics among dentistry students: a cross -sectional study." Concilium 24, no. 17 (August 31, 2024): 352–66. http://dx.doi.org/10.53660/clm-3844-24r28.

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Aim: This study aimed to evaluate the degree of knowledge of biomaterials used in periodontics of dentistry undergraduate students from different semesters and universities in Brazil. Materials and Methods: The sample comprised 210 students from the fifth and tenth semesters of dentistry graduation courses. A two-part (Part I, sociodemographic items; Part II, 15 objective questions about biomaterials used in periodontics) questionnaire survey was conducted using Google Forms. Results: Most participants reported having some knowledge of biomaterials (57%), with 48% stating they had little knowledge. during graduation; were interested in biomaterials; considered feasible the use of biomaterials during the graduation course. Most students considered biomaterial use safe (97%) and specific qualification for biomaterial use to be unnecessary (58%). No statistically significant association was found between sociodemographic factors and the degree of knowledge of biomaterials. Discussion: The opportunity to work with biomaterials during graduation was associated with the degree of knowledge of biomaterials. Most participants did not have the opportunity to work with biomaterials during graduation and considered that they knew nothing or little about biomaterials. Conclusion: Based on the results, we conclude that there is a gap in theoretical and practical knowledge regarding biomaterial use in periodontics in dentistry graduation courses in Brazil.
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Kroiča, Juta, Ingus Skadiņš, Ilze Salma, Aigars Reinis, Marina Sokolova, Dagnija Rostoka, and Natālija Bērza. "Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics / Bionoārdāmu Polimēru Saturošu Un Ar Antibiotiskajām Vielām Piesūcinātu Biomateriālu Antibakteriālās Efektivitātes Noteikšana." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 70, no. 4 (August 1, 2016): 220–26. http://dx.doi.org/10.1515/prolas-2016-0035.

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Abstract Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.
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Susin, Cristiano, Jaebum Lee, Tiago Fiorini, Ki-Tae Koo, Peter Schüpbach, Amanda Finger Stadler, and Ulf ME Wikesjö. "Screening of Hydroxyapatite Biomaterials for Alveolar Augmentation Using a Rat Calvaria Critical-Size Defect Model: Bone Formation/Maturation and Biomaterials Resolution." Biomolecules 12, no. 11 (November 12, 2022): 1677. http://dx.doi.org/10.3390/biom12111677.

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Background: Natural (bovine-/equine-/porcine-derived) or synthetic hydroxyapatite (HA) biomaterials appear to be the preferred technologies among clinicians for bone augmentation procedures in preparation for implant dentistry. The aim of this study was to screen candidate HA biomaterials intended for alveolar ridge augmentation relative to their potential to support local bone formation/maturation and to assess biomaterial resorption using a routine critical-size rat calvaria defect model. Methods: Eighty adult male Sprague Dawley outbred rats obtained from a approved-breeder, randomized into groups of ten, were used. The calvaria defects (ø8 mm) either received sham surgery (empty control), Bio-Oss (bovine HA/reference control), or candidate biomaterials including bovine HA (Cerabone, DirectOss, 403Z013), and bovine (403Z014) or synthetic HA/ß-TCP (Reprobone, Ceraball) constructs. An 8 wk healing interval was used to capture the biomaterials’ resolution. Results: All biomaterials displayed biocompatibility. Strict HA biomaterials showed limited, if any, signs of biodegradation/resorption, with the biomaterial area fraction ranging from 22% to 42%. Synthetic HA/ß-TCP constructs showed limited evidence of biodegradation/erosion (biomaterial area fraction ≈30%). Mean linear defect closure in the sham-surgery control approximated 40%. Mean linear defect closure for the Bio-Oss reference control approximated 18% compared with 15–35% for the candidate biomaterials without significant differences between the controls and candidate biomaterials. Conclusions: None of the candidate HA biomaterials supported local bone formation/maturation beyond the native regenerative potential of this rodent model, pointing to their limitations for regenerative procedures. Biocompatibility and biomaterial dimensional stability could suggest their potential utility as long-term defect fillers.
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Goldis, Goldis, and Chirila. "Biomaterials in Gastroenterology: A Critical Overview." Medicina 55, no. 11 (November 12, 2019): 734. http://dx.doi.org/10.3390/medicina55110734.

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In spite of the large diversity of diagnostic and interventional devices associated with gastrointestinal endoscopic procedures, there is little information on the impact of the biomaterials (metals, polymers) contained in these devices upon body tissues and, indirectly, upon the treatment outcomes. Other biomaterials for gastroenterology, such as adhesives and certain hemostatic agents, have been investigated to a greater extent, but the information is fragmentary. Much of this situation is due to the paucity of details disclosed by the manufacturers of the devices. Moreover, for most of the applications in the gastrointestinal (GI) tract, there are no studies available on the biocompatibility of the device materials when in intimate contact with mucosae and other components of the GI tract. We have summarized the current situation with a focus on aspects of biomaterials and biocompatibility related to the device materials and other agents, with an emphasis on the GI endoscopic procedures. Procedures and devices used for the control of bleeding, for polypectomy, in bariatrics, and for stenting are discussed, particularly dwelling upon the biomaterial-related features of each application. There are indications that research is progressing steadily in this field, and the establishment of the subdiscipline of “gastroenterologic biomaterials” is not merely a remote projection. Upon the completion of this article, the gastroenterologist should be able to understand the nature of biomaterials and to achieve a suitable and beneficial perception of their significance in gastroenterology. Likewise, the biomaterialist should become aware of the specific tasks that the biomaterials must fulfil when placed within the GI tract, and regard such applications as both a challenge and an incentive for progressing the research in this field.
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Uthai, Wichai, Kreunate Jittiporn, PongThanya Pongsuda, and Aumnate Chuanchom. "D-5 BIOMATERIAL INDICATOR FOR PATHOGEN SAFE IN FERMENTED PRODUCTS(Session: Biomaterials)." Proceedings of the Asian Symposium on Materials and Processing 2006 (2006): 74. http://dx.doi.org/10.1299/jsmeasmp.2006.74.

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Atheena, Milagi Pandian S., Murugan Rashika, M. Sudherson, and Sakthi M. Kriya. "Biomaterial strategies for immune system enhancement and tissue healing." i-manager’s Journal on Future Engineering and Technology 20, no. 1 (2024): 1. https://doi.org/10.26634/jfet.20.1.21086.

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Recent biomaterials like nanoparticles, graphene, and functional hydrogels are advancing tissue engineering and disease therapy through immunomodulation, tissue regeneration, and cancer therapy. This study explores the role of biomaterials in enhancing immune responses and promoting tissue regeneration. Implantable biomaterials offer innovative therapeutic effects in various disease situations. Understanding the interactions between biomaterials and host cells is crucial for creating therapeutic biomaterials that facilitate tissue integration and mitigate foreign body reactions. This study emphasizes how biomaterial properties, like size, shape, surface composition, and mechanical characteristics, influence immune cell responses, particularly macrophage polarization, which is crucial for minimizing inflammation and supporting tissue repair. The findings underscore the importance of tailored biomaterial design to mitigate foreign body reactions, improve biocompatibility, and ultimately enhance patient outcomes.
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Ramesh, B., Anandhi R J, Vanya Arun, Atul Singla, Pradeep Kumar Chandra, Vandana Arora Sethi, and Ahmed Salam Abood. "A Review on Biomaterials for Neural Interfaces: Enhancing Brain-Machine Interfaces." E3S Web of Conferences 505 (2024): 01005. http://dx.doi.org/10.1051/e3sconf/202450501005.

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Biomaterials are essential to the development of neural interfaces, including brainmachine interfaces. Biomaterial methods improve neural interface functionality, compatibility, and longevity, enabling brain-device communication. An extensive investigation of biomaterials utilized in brain electrode arrays, neural probes, & implantable devices rely on how materials affect neural signals recording, stimulation, & tissue contact. It also investigates how biomaterials, bioelectronics and 3D printing could improve neural interfaces. Biomaterials modulate neuroinflammatory responses, enhance brain tissue regeneration, and promote neural interface longevity. This study shows the potential for change of biomaterial-based neural interfaces in neuroprosthetics, neurological rehabilitation, and fundamental neuroscience research, addressing the need for brain-machine relationship and neurotechnology innovation. These findings suggest expanding biomaterials research and development to advance and sustain neural interface technologies for future use.
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Courtney, J. M., L. Irvine, C. Jones, S. M. Mosa, L. M. Robertson, and S. Srivastava. "Biomaterials in Medicine - A Bioengineering Perspective." International Journal of Artificial Organs 16, no. 3 (March 1993): 164–71. http://dx.doi.org/10.1177/039139889301600311.

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Biomaterials are considered with an emphasis on those used in artificial organs. Attention is drawn to the importance of the polymeric biomaterials and factors which affect their properties. Functions of membranes, sorbents, blood tubing, ventricular diaphragms and cell culture substrates are examined in order to obtain a summary of fundamental properties. Observations are made on the importance of blood compatibility assessment and its association with a biomaterial structure-property relationship. Blood-biomaterial interactions are discussed in terms of an overall relationship between the three components –- blood, biomaterial and antithrombotic agent, with examples given of factors influencing each component. Cell-biomaterial interactions are examined in the areas of toxicity evaluation and the promotion of cell attachment and growth, where an overall relationship is described for the cell, growth medium and growth factors, and the biomaterial acting as a substrate.
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Lu, Tao, Yuqin Qiao, and Xuanyong Liu. "Surface modification of biomaterials using plasma immersion ion implantation and deposition." Interface Focus 2, no. 3 (March 21, 2012): 325–36. http://dx.doi.org/10.1098/rsfs.2012.0003.

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Although remarkable progress has been made on biomaterial research, the ideal biomaterial that satisfies all the technical requirements and biological functions is not available up to now. Surface modification seems to be a more economic and efficient way to adjust existing conventional biomaterials to meet the current and ever-evolving clinical needs. From an industrial perspective, plasma immersion ion implantation and deposition (PIII&D) is an attractive method for biomaterials owing to its capability of treating objects with irregular shapes, as well as the control of coating composition. It is well acknowledged that the physico-chemical characteristics of biomaterials are the decisive factors greatly affecting the biological responses of biomaterials including bioactivity, haemocompatibility and antibacterial activity. Here, we mainly review the recent advances in surface modification of biomaterials via PIII&D technology, especially titanium alloys and polymers used for orthopaedic, dental and cardiovascular implants. Moreover, the variations of biological performances depending on the physico-chemical properties of modified biomaterials will be discussed.
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Dissertations / Theses on the topic "Biomaterials"

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FONTANA, FEDERICO. "Computational Approaches for biomaterials characterization and biomaterial-cell interactions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/301794.

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I biomateriali per applicazioni di ingegneria dei tessuti devono soddisfare diversi requisiti, come sicurezza, biocompatibilità e caratteristiche meccaniche appropriate. Il processo di sviluppo di questi biomateriali comprende diversi approcci scientifici, che vanno dall' in-silico all'in-vivo. L'ottimizzazione in silico delle caratteristiche dei biomateriali sta attirando un'attenzione sempre maggiore. Infatti, il miglioramento di questo approccio consentirà di ridurre i costi aggiuntivi nel processo di sviluppo dei biomateriali, a causa di caratterizzazioni sperimentali non necessarie. Secondo questo punto di vista, in questa tesi viene presentato un approccio di dinamica molecolare per la caratterizzazione dei biomateriali. Più in dettaglio, gli scaffold degli idrogel di peptidi autoassemblanti (SAP) sono stati studiati su nanoscala e microscala, al fine di chiarire le loro relazioni intrinseche struttura-proprietà-funzione. Le dinamiche molecolari atomistiche a grana grossa (CG-MD) sono state utilizzate per studiare i meccanismi di auto-assemblamento che portano alla formazione di scaffold peptidici. A causa della mancanza di informazioni strutturali cruciali nelle simulazioni CG-MD, l'innovativa suite software, denominata Morphoscanner, è stata impiegata per la classificazione dei modelli di aggregazione conformazionale dei SAP. Quindi, le proprietà meccaniche e i meccanismi di rottura delle nanostrutture SAP sono stati studiati attraverso le simulazioni MD vincolate. Queste evidenze hanno portato allo sviluppo di un approccio CG-MD che mira a chiarire la complessa interazione tra membrane cellulari e nanofibrille SAP. In particolare, le simulazioni MARTINI CG-MD sono state utilizzate per comprendere gli effetti della nanofibrille peptidiche sulla dinamica dei domini lipidici nelle membrane neurali. Tali risultati aprono nuove dimensioni nel campo della biomateriomica, consentendo di comprendere ed eventualmente controllare i complessi fenomeni che influenzano le proprietà meccaniche e la biocompatibilità dei biomateriali a base peptidica per applicazioni di ingegneria tissutale.
Biomaterials for tissue engineering applications have to comply with several requirements, such as safety, biocompatibility and appropriate mechanical features. The development process of these biomaterials encompasses several scientific approaches, ranging from in-silico to in-vivo. The in-silico optimization of biomaterials features is attracting even larger attention. Indeed, the improvement of this approach will allow to reduce additional costs int the biomaterials development process, due to unnecessary experimental characterizations. According to this point-of-view, in this thesis is presented a molecular dynamics approach for biomaterial characterization. More in details, self-assembling peptides (SAPs) hydrogels scaffolds have been investigated at the nano-scale and micro-scale, to elucidate their intrinsic structure-property-function relationships. The atomistic and coarse-grained molecular dynamics (CG-MD) have been used for the elucidation of self-assembling pathways of peptide-based scaffolds. Due to the lack of crucial structural information in CG-MD simulations, the innovative software suite, dubbed Morphoscanner, has been employed for the elucidation of conformational aggregation patterns of SAPs. Then, the mechanical properties and failure mechanisms of SAPs nanostructures have been investigated through the steered MD simulations. These evidences led the development of a CG-MD approach aiming to elucidate the complex interplay between cell membranes and SAPs nanofibrils. In particular, MARTINI CG-MD simulations have been used for understanding the effects of SAPS nanofibril on dynamics of lipid domains in neural membranes. Such achievements open up new dimensions in the field of biomateriomics, allowing to understand and eventually orchestrate the complex phenomena which affect the mechanical properties and biocompatibility of SAPs biomaterials for tissue engineering applications.
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Carlsson, Louise. "Hierarchical Micro- and Nanostructured Superhydrophobic Surfaces to Reduce Fibrous Encapsulation of Pacemaker Leads : Nanotechnology in Practical Applications." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71067.

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The purpose of this master’s thesis was to, by the use of nanotechnology, improve material properties of the biomedical polymer Optim™, used as the insulation of pacemaker leads. Improved material properties are required to reduce the extent of fibrous encapsulation of the leads. Today, laser ablation is used to be able to remove the pacemaker lead because of the fibrous tissue, which can cause the lead to adhere to vascular structures. Consequently, the laser ablation results in risks of damaging cardiovascular structures. Moreover, improved material properties are needed to reduce the friction at the surface and enhance the wear resistance. Large wearing occurs between the lead and the titanium pacemaker shell as well as lead against lead and the wearing can result in a damaged insulation, which in turn might result in removal of the device. To achieve these improved material properties a hierarchically micro- and nanostructured and superhydrophobic surface was fabricated and to enhance the wear resistance, nanocomposites with 1 wt % and 5 wt % added hydroxyapatite nanoparticles were fabricated. The surface structures were fabricated via hot embossing and plasma treatment and were characterised with atomic force microscopy, environment scanning electron microscopy and with contact angle measurements. To evaluate the biological response to the surfaces, adsorption of radioisotope labelled human serum albumin proteins and adhesion of the human fibroblast cell line MRC-5 were studied. The results show that a superhydrophobic surface, with contact angle as high as 170.0 ± 0.4 °, can be fabricated via hierarchically micro- and nanostructures on an Optim™ surface. The fabricated surface is more protein resistant and cell resistant compared to a smooth surface. The nanocomposites fabricated, especially the one with 5 wt % nanoparticles added, show an enhanced abrasive wear resistance compared to Optim™ without added nanoparticles. In conclusion, a hierarchically micro- and nanostructured superhydrophobic surface of the pacemaker lead seems promising for reducing the extent of fibrous encapsulation and by fabricating a nanocomposite, the abrasive wear damage of the lead insulation can be reduced.
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Vásquez, Sancho Fabián. "Flexoelectricity in biomaterials." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/643308.

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La flexoelectricidad es la capacidad de los materiales para generar electricidad al deformarse de forma no homogénea. Es una propiedad de todos los materiales y, en principio, posible que existiera en biomateriales. De hecho, ya se ha observado en estereocilios del oído interno, apuntando a su importancia para la transducción acústico-eléctrica en la audición de mamíferos. Esta tesis investiga las propiedades flexoeléctricas de varios compuestos biocerámicos, que van desde los huesos hasta el coral, poniendo énfasis no solo en medir las propiedades flexoeléctricas, sino también en relacionarlas con su papel fisiológico. El Capítulo 1 introduce el tema de mecanoelectricidad de materiales y ofrece una visión general de los biomateriales estudiados en esta tesis. En el Capítulo 2, se desarrolla un análisis teórico de las propiedades mecanoeléctricas de los sistemas no homogéneos. En biomateriales, la flexoelectricidad y piezoelectricidad no pueden separarse tan fácilmente como en el caso de las muestras cristalinas o cerámicas que son regulares y con propiedades definidas. Los biomateriales nos obligaron a considerar situaciones en las que la flexoelectricidad y piezoelectricidad pueden actuar a la vez. También, situaciones en las que la piezoelectricidad es capaz de disfrazarse como flexoelectricidad o viceversa, con el objetivo de establecer el marco conceptual para las mediciones y los resultados de los siguientes capítulos. El Capítulo 3 describe y analiza las mediciones macroscópicas de flexoelectricidad en hidroxiapatita y huesos. La polarización inducida de ambos materiales arrojó resultados muy similares, lo que demuestra que la hidroxiapatita puede explicar la mayor parte de la polarización de los huesos sin necesidad de invocar la piezoelectricidad del colágeno. Teniendo en cuenta que la flexoelectricidad es más relevante a la microescala, donde los gradientes de deformación son más grandes, el Capítulo 4 desarrolla un modelo para estudiar los campos flexoeléctricos en torno a las microgrietas en los huesos. La magnitud de los campos eléctricos generados por un crack puede inducir la apoptosis en los osteocitos que es el primer paso en el proceso de remodelación ósea. En el Capítulo 5, realizamos experimentos in vitro con osteocitos y osteoblastos para determinar si los campos flexoeléctricos pueden afectar a las células. Observamos no solo que los campos flexoeléctricos generados por grietas pueden inducir apoptosis de células en el corto plazo, sino que, en los experimentos de cultivos a largo plazo, la flexoelectricidad también puede estimular la diferenciación de las células. En el Capítulo 6, exploramos las propiedades mecanoeléctricas de otros biomateriales como los dientes, coral y el martillo de un camarón. Los dientes están compuestos por los mismos constituyentes que los huesos, y por lo tanto, es un buen material para comparar con el hueso. Mientras tanto, el coral es un material comúnmente utilizado como injerto óseo debido a las similitudes con el hueso. Al comparar las propiedades flexoeléctricas de ambos materiales, pudimos determinar que también son muy similares, lo que nos lleva a pensar que la compatibilidad flexoeléctrica puede ser un factor de ayuda en el buen desempeño de los injertos óseos coralinos, una posibilidad que proponemos explorar en otros candidatos para injertos óseos. Finalmente, el martillo de un camarón tiene una capacidad sobresaliente para soportar el estrés sin fracturarse y este fenómeno nos motivó a estudiar las propiedades mecanoeléctricas del martillo, ya que la flexoelectricidad afecta las propiedades mecánicas de la materia. Finalmente, el Capítulo 7 brinda una descripción personal de las perspectivas y líneas futuras que podrían derivarse de esta investigación. La descripción completa de los procedimientos experimentales para experimentos electromecánicos y biológicos y el algoritmo de Mathematica que programé para calcular los campos flexoeléctricos alrededor de las grietas se encuentran en los apéndices.
Flexoelectricity is the ability of materials to generate electricity upon being bent, or, more generally, upon being inhomogeneously deformed. It is a property that is allowed by symmetry in all materials and, therefore, it was in principle possible that it existed in biomaterials –one precedent existed for their observation in inner-ear stereocilia, in fact, pointing to its importance for acousto-electric transduction in mammalian hearing. In this context, this thesis investigates into the flexoelectrical properties of several biologically-produced ceramic composites, ranging from bones to coral, putting emphasis not only on measuring the flexoelectrical properties, but also in connecting them to their potential physiological role. Chapter 1 introduces the topic of the mechanoelectric properties of piezoelectricity and flexoelectricity, and gives an overview of the biomaterials studied in this thesis. In Chapter 2, a theoretical analysis of the mechanoelectric properties of inhomogeneous systems is developed. For biomaterials, flexoelectricity and piezoelectricity cannot be as easily separeted as in the case of crystal or ceramic samples that are regular and with defined properties. The use of biomaterials forced us to consider situations in which flexoelectricity and piezoelectricity may act together. Situations in which piezoelectricity is able to disguise itself as flexoelectricity or vice-versa are presented, with an aim to lay the conceptual framework for the electromechanical measurements and results of the following chapters. Chapter 3 describes the characterization and analysis of macroscopic measurements of flexoelectricity in hydroxyapatite and bones. Bending-induced polarization of both kinds of samples yielded very similar results, which demonstrates that hydroxyapatite can account for most of the polarization of bones without needing to invoke collagen piezoelectricity. Considering that flexoelectricity is more relevant at the microscale, where strain gradients are bigger, in Chapter 4, we developed a model to study flexoelectric fields around microcracks in bones. We determined that the magnitude of the electric fields generated by a loaded crack can induce apoptosis in osteocytes. Osteocyte apoptosys is known to be the first step in the bone remodeling process. In Chapter 5, we performed in vitro experiments with osteocytes and osteoblast to probe whether flexoelectric fields are indeed able to affect cells. We observed not only that crack-generated flexoelectric fields experiments are able to induce apoptosys of cells in the short term, but in the long-term culture experiments, flexoelectricity is also able to stimulate the differentiation of cells. Finally, in Chapter 6, we explored the mechanoelectric properties of other Ceramic-based biomaterials such as teeth, coral skeleton, and the club of a stomapod. In the case of teeth, they are composed by the same constituents as bones, and they were therefore a good material to compare with bone. Meanwhile, coral skeleton is a material commonly used as a bone graft due to the similarities with bone. By comparing flexoelectric properties of both materials, we were able to determine that they are also very similar, leading us to hypothesise that flexoelectric compatibility may be a helping factor in the good performance of coral-based bone grafts, a possibility we propose to explore in other candidates for bone grafts. Finally, the club of a stomapod has an outstanding capacity to stand stress without fracture and this phenomenon motivated us to study the mechanoelectric properties of the club, as flexoelectricity is known to affect the mechanical properties of matter. Finally, Chapter 7 gives a personal overview of the perspectives and future lines that could derive from this research. The complete description of experimental procedures for electromechanical and biological experiments is in Appendix ), and Appendix B is the Mathematica algorithm that I programmed for calculating flexoelectric fields around cracks.
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Richter, Maja. "Study of immune and haemostatic response induced by protein multilayers." Thesis, Linköpings universitet, Tillämpad Fysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62304.

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FibMat2.0 is a fibrinogen multilayer developed by AddBIO. Other proteins such as immunoglobulin G (IgG) and human serum albumin (HSA) can also be used to build multilayers with the same technique. The aim of this study of FibMat2.0 was to investigate if the manufacturing of the protein multilayer would induce an immune or haemostatic response in the body. The multilayers of IgG and HSA were also studied. Methods such as null ellipsometry, imaging of coagulation and the cone-and-plate setup were used to study immune reactions, activation of the coagulation cascade, and stability of the multilayers. Small amounts of plasma proteins were adsorbed to fibrinogen multilayers, but complement proteins adsorbed only to the IgG matrix and high molecular weight kininogen (HMWK) adsorbed only to the HSA monolayer. The imaging of coagulation method indicated that the titanium surface and the HSA monolayer activate surface induced coagulation rapidly, whereas fibrinogen and IgG multilayers demonstrated longer coagulation times. Platelets and a few white blood cells were bound to titanium surfaces and fibrinogen multilayers, but not to IgG multilayers or HSA monolayers. A conclusion in this study is that the surface of an implant can be coated with FibMat2.0 without any risks, but more studies are needed to better understand the interactions between the surfaces prepared in the present study and the immune and the haemostatic systems of the human body.
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Matl, Florian. "Infected Biomaterials." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-95998.

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Jansson, Eva. "Blood protein coated model biomaterials : preparation, and cell and tissue response /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/tek798s.pdf.

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Karlsson, Linda. "Biomolecular interactions with porous silicon /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/tek804s.pdf.

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McGoldrick, Niamh. "Light triggered biomaterials." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579751.

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Implantable devices such as urethral catheters are the most commonly used urological devices. The most common problem affecting these devices is infection, leading to significant morbidity and eventual mortality. The challenge is to alleviate the long-term issue of device related infection. This study involved the development of light-responsive biomaterials, which demonstrated the controlled release of model therapeutic agents from within the polymer matrix, when irradiated with a specific wavelength of light. The use of light as a trigger for the release of a therapeutic agent from a polymeric matrix is attractive, as wavelength, intensity, site and duration of application of light can be coupled to release of the therapeutic agent. The pphotolabile ester of3,5-dimethoxybenzoin with a model acidic drug (ibuprofen) attached was synthesised and loaded into the polymer scaffold, which comprised of2-(hydroxyethyl) methacrylate crosslinked with ethyleneglycol dimethacrylate, once irradiated, the porous hydrogel allowed the diffusion of the model drug from the polymer matrix once liberated, and the retention of the photolytic by-product within the polymer structure. A second 3,5-dimethoxybenzoin ester was synthesised with ciprofloxacin attached, achieving controlled release of an antimicrobial in situ, thus preventing bacterial adherence and subsequent biofilm formation. The idea of chromatic orthogonality was explored and the 3,5-dimethoxybenzoin and nitrobenzyl derivatives were synthesised and utilised due to their differential reactivities at specific wavelengths, allowing multi-drug release, stimulated using monochromic light of different wavelengths. Light triggered transdermal drug delivery was examined,. novel pHEMA microneedles with the light reactive conjugate incorporated into the matrix were successfully synthesised. Drug release studies demonstrated the ability of the pHEMA microneedles to penetrate the synthetic skin and deliver the model drug ibuprofen. Modification of the surface ofa silicone biomaterial to allow the incorporation of two different porphyrins Meso- Tetraphenylporphyrin and Protoporphyrin IX was carried out, in order to develop an anti-adherent surface, preventing attachment of microorganisms and subsequent biofilm formation. An anti-infective surface has been developed which is successful at preventing bacterial colonisation of Gram-positive microorganism. The concept of light-triggered drug release of a model therapeutic agent from a hydrogel biomaterial has been demonstrated, it offers an exciting new prospect within drug delivery.
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McCullagh, S. D. "Novel silicone biomaterials." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273237.

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Engberg, Anna E. "Biomaterials and Hemocompatibility." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-5437.

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Biomaterials are commonly used in the medical clinic today; however, artificial materials can activate the cascade systems in the blood (complement-, coagulation-, contact- and fibrinolytic systems) as well as the platelets to various degrees. When an artificial surface comes in contact with blood, plasma proteins will be adsorbed to the surface within seconds. The composition of the layer of proteins differs between materials and is crucial for the hemocompatibility of the material. This thesis includes five projects. In Paper I the anticoagulants heparin and the thrombin inhibitor hirudin were evaluated in a whole blood model. Hirudin was found to be superior to low dose heparin since it did not affect the activation of the complement system nor the leukocytes. The most interesting observation was that expression of TF was seen on surface-attached monocytes in hirudin- treated blood but not heparin blood. In Paper II peptides from the streptococcal M-protein, which has affinity for the human complement inhibitor C4BP, were attached to a polymeric surface. When being exposed to blood the endogenous complement regulator was enriched at the surface of the material, via the M-peptides. With this new approach we created a self-regulatory surface, showing significant lowered material-induced complement activation. In Paper III apyrase, an enzyme which hydrolyzes nucleoside ATP and ADP, was immobilized on a polymer surface. Lower platelet activation and platelet-induced coagulation activation was seen for the apyrase-coated surface compared to control surfaces after exposure to whole human blood, due to the enzymes capability to degrade ADP released from activated platelets. In Paper IV and V we synthesized an array of polymeric materials which were characterized regarding physical-chemical properties, adsorption of plasma proteins, and hemocompatibility. The polymers showed widely heterogeneous protein adsorption. Furthermore, when the polymers were exposed to whole blood, two of the materials showed superior hemocompatibility (monitored as complement- and coagulation activation), compared to the reference poly(vinyl chloride).
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Books on the topic "Biomaterials"

1

Combe, E. C. Dental biomaterials. Boston: Kluwer Academic, 1999.

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Park, Joon B., and Roderic S. Lakes. Biomaterials. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-2156-0.

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Kulshrestha, Ankur S., Anil Mahapatro, and Lori A. Henderson, eds. Biomaterials. Washington, DC: American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1054.

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Migonney, Véronique, ed. Biomaterials. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781119043553.

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Byrom, David, ed. Biomaterials. London: Palgrave Macmillan UK, 1991. http://dx.doi.org/10.1007/978-1-349-11167-1.

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Hasirci, Nesrin, and Vasif Hasirci, eds. Biomaterials. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-0-306-48584-8.

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Helsen, Jozef A., and Yannis Missirlis. Biomaterials. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12532-4.

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Bhat, Sujata V. Biomaterials. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0328-5.

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Park, Joon Bu. Biomaterials. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4684-3423-1.

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Bhat, Sujata V. Biomaterials. Boston: Kluwer Academic Publishers, 2002.

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Book chapters on the topic "Biomaterials"

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Lawes, P. "Biomaterials." In Biomechanics of Normal and Pathological Human Articulating Joints, 285–311. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5117-4_14.

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Wesolowski, Robert A., Anthony P. Wesolowski, and Roumiana S. Petrova. "Biomaterials." In The World of Materials, 75–78. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-17847-5_12.

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Detsch, Rainer, Julia Will, Jasmin Hum, Judith A. Roether, and Aldo R. Boccaccini. "Biomaterials." In Cell Culture Technology, 91–105. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74854-2_6.

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Sillanpää, Mika, and Chaker Ncibi. "Biomaterials." In A Sustainable Bioeconomy, 185–231. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55637-6_6.

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Vaca-Garcia, Carlos. "Biomaterials." In Introduction to Chemicals from Biomass, 103–42. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470697474.ch5.

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Bayne, Stephen C. "Biomaterials." In Toothwear: The ABC of the Worn Dentition, 153–67. West Sussex, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118785058.ch9.

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Pei, Lei, Rachel Armstrong, Antoine Danchin, and Manuel Porcar. "Biomaterials." In Synthetic Biology, 103–43. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527659296.ch3.

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Bergmann, Carlos P., and Aisha Stumpf. "Biomaterials." In Dental Ceramics, 9–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-38224-6_2.

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Mittal, Manoj. "Biomaterials." In Functional and Smart Materials, 165–94. First edition. | Boca Raton, FL : CRC Press, 2020. |: CRC Press, 2020. http://dx.doi.org/10.1201/9780429298035-9.

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Sabu, S. "Biomaterials." In Fish Structural Proteins and its Derivatives: Functionality and Applications, 181–98. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-2562-5_8.

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Conference papers on the topic "Biomaterials"

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Karyasa, I. Wayan, and Enike Dwi Kusumawati. "Strategy for Developing Medical Inorganic-Organic Hybrid Biomaterials through the Improvement of Sericulture as a Producer of Renewable Active Biological Raw Materials." In 8th International Conference on Advanced Material for Better Future, 95–106. Switzerland: Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-yox7jx.

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The need for biomaterials is increasing as more and more health problems become more and more complex. Progress in the field of medical biomaterials is also accelerating, but the provision of renewable biomaterials continues to be of concern to the world as awareness of sustainable development in the field of chemistry and health. Various strategies in the development of medical biomaterials were studied through a narrative review of the literature. One of them is the strategy of developing inorganic-organic hybrid medical biomaterials through the cultivation of silkworms as producers of renewable biomaterial raw materials. Sericulture can produce active biomaterials such as sericin, fibroin and other renewable materials and those biomaterials can be combined with inorganic nanoparticles to produce medical functional biomaterials on an ongoing basis. The addition of antibacterial bioactive materials such as natural dyestuffs and inorganic nanoparticles of anti-bacterial agents can increase the productivity and quality of antimicrobial biomaterials produced by the cultivation of silkworms.
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Mar, Walter, Tomy Suarez, and Carlos Diaz Novo. "Functional Validation of Biomaterials for Tarsometatarsal Prosthesis." In 2024 IEEE URUCON, 1–4. IEEE, 2024. https://doi.org/10.1109/urucon63440.2024.10850337.

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Tuan, Rocky S. "Functional Analysis of Bone-Biomaterial Interface." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2675.

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Abstract Proper function and long-term stability of orthopaedic implants depend on the intimate association between bone cells and the implant biomaterial, a process known as osseointegration. Understanding the processes responsible for the establishment and maintenance of a functional bone-biomaterial interface and how these processes may be enhanced is crucial to the rational design and optimization of prosthetic devices. We have utilized cellular, molecular, and high-resolution imaging approaches to analyze the mechanistic basis of bone-biomaterial interactions. Specifically, we have characterized the initial adhesion of osteoblasts in terms of kinetics and relationship to the surface topography and chemistry of the biomaterials, particularly the cobalt-chrome and titanium alloys commonly used to fabricate orthopaedic prostheses. Results from these studies indicate that the long-term performance of osteoblasts adherent to biomaterials is crucially dependent on the characteristics of the initial adhesion step. Furthermore, osteoactive factors such as members of the transforming growth factor-β superfamily, including TGF-β1 and BMP-2, significantly enhance osteoblast cell adhesion. The molecular components responsible for the adhesion process include extracellular matrix proteins (e.g. fibronectin and collagen type I) and their cognate membrane receptors, the integrins. Our recent studies reveal that specific downstream, intracellular signaling events are also activated as a result of osteoblast adhesion, and that these signaling events are coupled to signal transduction mechanisms mediating growth factor activity. These events in combination regulate the continued expression and maintenance of the osteoblastic phenotype of the adherent cells, resulting in matrix maturation and mineralization, hallmarks of the bony tissue. Our current efforts focus on defining the target molecular pathways responsible for bone cell functioning on biomaterials, and the identification of critical biological and material parameters to optimize long-term osteoblast function and interaction with orthopaedically relevant biomaterials. The information gathered from these studies should provide a rational basis for the design of optimal implant biomaterials. (Supported in part by the NIH and the Annenberg Foundation)
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Gloeckner, D. Claire, and Michael S. Sacks. "Biaxial Fiber Kinematics and Structural Constitutive Modeling of Small Intestinal Submucosa." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0164.

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Abstract Small intestinal submucosa (SIS) has been studied as a potential biomaterial for use in tissue engineering applications. Extracted from the mammalian small bowel, it consists of two collagen fiber populations at ∼±30° from the longitudinal axis. We have previously investigated the biaxial mechanical properties of SIS (Sacks and Gloeckner, 1998), which were comparable to other bioprosthetic biomaterials. Our long-term goal is to develop structural constitutive models of implantable biomaterials made from SIS and other acellular materials. These models can aid in determining how well a biomaterial will perform in the virgin and remodeled states. Structural models require quantitative morphologic information, especially fiber structure and kinematics. In this study, we examined the change in the fiber kinematics at different states of biaxial stretch and developed an initial structural constitutive model for SIS.
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Sanders, Joan E., Sam T. Bishop, Charlotte E. Stiles, and Philipp K. Schuessler. "Fibroin and Polymer-Based Fibroporous Biomaterials: Candidate Materials for Biomechanical Implants?" In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0919.

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Abstract A technique from the paper manufacturing industry was used to manufacture fibroporous meshes for potential biomaterial implant applications. Meshes were made from small diameter (10 μm) bombyx mori cocoon silk (fibroin). Meshes with a range of fiber lengths were created, though at long fiber lengths flocculation (clumping of fibers) tended to occur. Load-deformation curves were nonlinear with lower slopes at high loads than at low loads, contrary to natural soft-tissue biomaterials. Single fiber in vivo studies to evaluate tissue response sensitivity to biomaterial architectural features demonstrated reduced fibrous encapsulation for smaller diameter fibers (2.6 μm) than larger ones (10 μm). Thus the use of small diameter fibers in biomaterial fibrous implants is a viable concept, and it should be pursued. However, alternative methods to the paper manufacturing process will need to be used for mesh fabrication.
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Chu, P. K. "Plasma-treated biomaterials." In The 33rd IEEE International Conference on Plasma Science, 2006. ICOPS 2006. IEEE Conference Record - Abstracts. IEEE, 2006. http://dx.doi.org/10.1109/plasma.2006.1707264.

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"Session 4: Biomaterials." In 2020 Mechatronics Systems and Materials (MSM). IEEE, 2020. http://dx.doi.org/10.1109/msm49833.2020.9202315.

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Mahmoud, Rahmatul, Quang Nguyen, Gordon Christopher, and Paul F. Egan. "3D Printed Food Design and Fabrication Approach for Manufacturability, Rheology, and Nutrition Trade-Offs." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-70663.

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Abstract 3D printing enables the production of personalized designs that are desirable in the medical industry for applications including orthopedics, tissue engineering, and personalized nutrition. Currently, the design process relies on trial-and-error approaches, especially for biomaterial development, and there is a need for methodologies to streamline the design process to facilitate automation. Here, we investigate a design methodology for printing foods by mixing novel biomaterial combinations informed by rheological measurements that indicate printability. The process consists of first printing basic designs with chocolate, marzipan, and potato biomaterials known to print consistently. Rheological measurements are collected for these materials and compared to a novel pumpkin biomaterial. The pumpkin had a higher complex modulus and lower mechanical loss tangent than all other biomaterials, therefore motivating the addition of rheological agents to reach more favorable properties. Varied concentrations of corn starch and guar gum were added to the pumpkin to improve printability while altering the nutrient distribution. A 4% inclusion of guar gum provided the most consistent pumpkin prints. A complex 3D object was fabricated with the 4% guar gum pumpkin material, therefore demonstrating the merits in using rheological properties to inform printability for use in design automation routines. The design approach enabled comparisons of relative nutrition and printability trade-offs to demonstrate a proof-of-concept user interface for design automation to facilitate customized food production. Further research to develop a complete design methodology for linking rheological properties to printability would promote consistent prediction of print quality for novel formulations to support design automation, with potential generalizability for diverse biomaterials.
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Ferreira, Pedro, and Gabriela Forman. "A Synaesthetic Design Study: a driver for the Perception of Colour on Textile Biomaterials Selection." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003528.

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The Selection of Materials is a field containing a group of criteria necessary to choose materials applied to the Design project. Several criteria were associated with this selection process, and just some of them were considered for the study (such as aesthetic properties related to colour and texture; intangible requirements like emotions, perceptions, and stimulus; and some specific biological properties connected to biomaterials in the textile context). The study aims to understand the visual colour stimulus of biomaterials from the perspective of the Synaesthetic Design phenomenon. The designer has a pertinent role in understanding the mechanism around social desires (environmental protection, impact of materials, transparency, traceability, and attractive products). Biomaterials are produced from various sources of feedstocks such as residues, wastes, and sub-products of raw materials. In these cases, the transformation of the materials is crucial to becoming valid on the market and desirable to the consumer. Thus, how can the designer create value opportunities using these materials? The literature review is a methodology integrated into this study through the addition of interdisciplinary areas that seek to generate systematic and holistic based reflections. The designer needs guidance on biomaterials and their visual interpretations, which are linked to emotions or sensorial desires of human behaviour and feelings to create empathy with them - specific materials based on descriptive criteria connected to the Selection of Materials field. Therefore, the study hopes to facilitate the growth of biomaterial application by offerings insight about these concepts and consideration on eventual opportunities for creating experiences and innovative products based on a thoughtful and informed selection, contributing to a deeper understanding of biomaterial and these properties within textiles, towards a Circular Bioeconomy view.
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Boland, Thomas, Xiaofeng Cui, Aditya Chaubey, Timothy C. Burg, Richard E. Groff, and Karen J. L. Burg. "Precision Printing of Cells and Biomaterials Onto 3D Matrices." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31023.

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The long term goal of our work is to develop a fabrication technique that allows precision placement of cells inside biomaterial constructs. Such spatial and temporal control of the chemistry and pattern geometry can provide new insights into fundamental aspects of cell-surface interactions. For example, cellular development can be dramatically effected by constraining cells to spread over a specific cell-surface contact area. The cell and biomaterial printing techniques developed here may prove particularly useful for exploring the interactions of anchorage-dependent cells with their environment in vitro. Our recent studies addressed the simultaneous printing of endothelial cells and biomaterials. The studies further demonstrated that cells can be printed onto polymer scaffolds or fibers without significant loss of cell activity. A combination of these methods may result in the construction of vascularized tissue with mechanical properties approaching those of native tissue.
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Reports on the topic "Biomaterials"

1

Urry, Dan W. Development of Elastomeric Polypeptide BIomaterials. Fort Belvoir, VA: Defense Technical Information Center, January 1998. http://dx.doi.org/10.21236/ada360942.

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Belcher, Angela M. Designed Electroresponsive Biomaterials: Sequence-Controlled Behavior. Fort Belvoir, VA: Defense Technical Information Center, June 2010. http://dx.doi.org/10.21236/ada533811.

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Sturrock, Charles P. Data and informatics needs in biomaterials. Gaithersburg, MD: National Institute of Standards and Technology, 2005. http://dx.doi.org/10.6028/nist.ir.7255.

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Daggett, Valerie. Simulation of Protein and Peptide-Based Biomaterials. Fort Belvoir, VA: Defense Technical Information Center, February 2002. http://dx.doi.org/10.21236/ada399142.

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Paige Perillat-Piratoine, Paige Perillat-Piratoine. Exploring self-powering biomaterials using embedded proteins. Experiment, March 2024. http://dx.doi.org/10.18258/67907.

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Snyder, A. P., Michael B. Wasserman, and Shirley A. Liebman. Time-Resolved Analytical Pyrolysis Mass Spectrometry of Biomaterials. Fort Belvoir, VA: Defense Technical Information Center, July 1991. http://dx.doi.org/10.21236/ada240624.

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Bruggeman, Peter. Non-Equilibrium Plasma Interactions with Biomaterials, Biological Solutions and Tissues. Office of Scientific and Technical Information (OSTI), January 2022. http://dx.doi.org/10.2172/1842416.

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Banasiak, Dennis, and Cody Ellens. Demonstration of pyrolysis based biorefinery concept for biopower, biomaterials and biochar. Office of Scientific and Technical Information (OSTI), August 2018. http://dx.doi.org/10.2172/1463690.

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Dragnea, Bogdan G. Final Scientific Report - Electromagnetic Interactions in Self-Assembled Metallo-Dielectric Biomaterials. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1354823.

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Dooley, James, Christopher Lanning, Juming Tang, Ren Yang, and Shuang Zhang. Preheating of Cold, High Moisture Particulate Biomaterials to Reduce Drying Time. Office of Scientific and Technical Information (OSTI), January 2023. http://dx.doi.org/10.2172/1922506.

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