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Journal articles on the topic 'Biomaterials, regenerative medicine, carbohydrates, proteins'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Farjana, H. Nilofer, and G. Mohan Valiathan. "Cissus quadrangularis: A comprehensive review as an emerging biomaterial for periodontal regeneration." Journal of Oral Research and Review 17, no. 1 (2025): 87–92. https://doi.org/10.4103/jorr.jorr_27_24.

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Cissus quadrangularis (CQ) is known for its use as a folk medicine for pharmacological properties such as antimicrobial, antiulcer, anti-inflammatory, antitumor, antihemorrhagic, antiallergic, antidiabetic, and antioxidant properties. It is known for its significant role in fracture healing and bone regeneration. To date, it is safe without any adverse effects when used within normal limits. It contains phytoconstituents such as carbohydrates, phytosterols, flavonoids, triterpenoids, glycosides, tannins, saponins, proteins, Vitamin C, alkaloids, and calcium. The alveolar bone is the tooth-supp

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Fernández-Villa, Daniel, Mirta Jiménez Gómez-Lavín, Cristina Abradelo, Julio San Román, and Luis Rojo. "Tissue Engineering Therapies Based on Folic Acid and Other Vitamin B Derivatives. Functional Mechanisms and Current Applications in Regenerative Medicine." International Journal of Molecular Sciences 19, no. 12 (2018): 4068. http://dx.doi.org/10.3390/ijms19124068.

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B-vitamins are a group of soluble vitamins which are cofactors of some of the enzymes involved in the metabolic pathways of carbohydrates, fats and proteins. These compounds participate in a number of functions as cardiovascular, brain or nervous systems. Folic acid is described as an accessible and multifunctional niche component that can be used safely, even combined with other compounds, which gives it high versatility. Also, due to its non-toxicity and great stability, folic acid has attracted much attention from researchers in the biomedical and bioengineering area, with an increasing num

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Nag, Kakon, and Toshihiro Akaike. "E-Cadherin – Fc Chimeric Protein-Based Biomaterial: Breaking the Barriers in Stem Cell Technology and Regenerative Medicine." Advanced Materials Research 810 (September 2013): 41–76. http://dx.doi.org/10.4028/www.scientific.net/amr.810.41.

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Chimeric proteins have been used for years for various purposes ranging from biomaterials to candidate drug molecules, and from bench to bulk. Regenerative medicine needs various kinds of proteins for providing essential factors for maintaining starting cells, like induced pluripotent stem cells (iPSC), and renewal, proliferation, targeted differentiation of these cells, and as extracellular matrix for the experimental cells. However, there are several challenges associated with making functional chimeric proteins for effective application as biomaterial in this field. Fc-chimeric protein tech

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Jahangirian, Azizi, Rafiee-Moghaddam, Baratvand, and Webster. "Status of Plant Protein-Based Green Scaffolds for Regenerative Medicine Applications." Biomolecules 9, no. 10 (2019): 619. http://dx.doi.org/10.3390/biom9100619.

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In recent decades, regenerative medicine has merited substantial attention from scientific and research communities. One of the essential requirements for this new strategy in medicine is the production of biocompatible and biodegradable scaffolds with desirable geometric structures and mechanical properties. Despite such promise, it appears that regenerative medicine is the last field to embrace green, or environmentally-friendly, processes, as many traditional tissue engineering materials employ toxic solvents and polymers that are clearly not environmentally friendly. Scaffolds fabricated f

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Li, Shuangyang, Qixuan Yu, Hongpeng Li, Meiqi Chen, Ye Jin, and Da Liu. "Self-Assembled Peptide Hydrogels in Regenerative Medicine." Gels 9, no. 8 (2023): 653. http://dx.doi.org/10.3390/gels9080653.

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Regenerative medicine is a complex discipline that is becoming a hot research topic. Skin, bone, and nerve regeneration dominate current treatments in regenerative medicine. A new type of drug is urgently needed for their treatment due to their high vulnerability to damage and weak self-repairing ability. A self-assembled peptide hydrogel is a good scaffolding material in regenerative medicine because it is similar to the cytoplasmic matrix environment; it promotes cell adhesion, migration, proliferation, and division; and its degradation products are natural and harmless proteins. However, fe

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Torres-Huerta, Ana Laura, Aurora Antonio-Pérez, Yolanda García-Huante, Nayelhi Julieta Alcázar-Ramírez, and Juan Carlos Rueda-Silva. "Biomolecule-Based Optical Metamaterials: Design and Applications." Biosensors 12, no. 11 (2022): 962. http://dx.doi.org/10.3390/bios12110962.

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Metamaterials are broadly defined as artificial, electromagnetically homogeneous structures that exhibit unusual physical properties that are not present in nature. They possess extraordinary capabilities to bend electromagnetic waves. Their size, shape and composition can be engineered to modify their characteristics, such as iridescence, color shift, absorbance at different wavelengths, etc., and harness them as biosensors. Metamaterial construction from biological sources such as carbohydrates, proteins and nucleic acids represents a low-cost alternative, rendering high quantities and yield

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Filipczak, Nina, Satya Siva Kishan Yalamarty, Xiang Li, Muhammad Muzamil Khan, Farzana Parveen, and Vladimir Torchilin. "Lipid-Based Drug Delivery Systems in Regenerative Medicine." Materials 14, no. 18 (2021): 5371. http://dx.doi.org/10.3390/ma14185371.

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The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems of

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Taghizadeh, Emad, Seyed Mohammad Mahdi Mirmohammadi, Arezoo Khosravi, Gholamreza Mojarab, and Hossein Shahoon. "Advances in Regenerative Medicine for the Treatment of Osteonecrosis of the Jaw." Galen Medical Journal 13, SP1 (2024): e3676. https://doi.org/10.31661/gmj.v13isp1.3676.

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Osteonecrosis of the jaw (ONJ) is a debilitating condition characterized by progressive bone tissue necrosis, commonly linked to bisphosphonates, radiation therapy, or trauma. Traditional treatments, such as surgical debridement and conservative management, often fail to fully restore bone function, driving the need for alternative therapeutic strategies. Regenerative medicine, particularly cellular therapies and biomaterials, has emerged as a promising field in ONJ treatment. This review explores recent advancements in regenerative approaches for ONJ, with a focus on Mesenchymal stem cells (M

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Kishan Shetty, Ashmitha, Serene Joy, Manasa Latha Biligowda, and Siddique Sha Muhammed Hussain. "Biomarkers of Pulpal Regeneration: Overview on Immunohistochemistry Analysis." ECS Transactions 107, no. 1 (2022): 17193–99. http://dx.doi.org/10.1149/10701.17193ecst.

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Immunocytochemistry (IHC) is a method that uses monoclonal and polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease. The method of recognizing a tissue component in situ utilizing unique antibody-antigen interactions in which the antibody is precisely labelled is referred to as IHC. It can be used to identify and localize well-known cellular structures and also extracellular matrix components. This method similarly provides information on the temporospatial distribution of newly discovered carbohydrates and proteins in development, illness

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Khosropanah, Mohammad Hossein, Mahdi Alizadeh Vaghasloo, Mehdi Shakibaei, et al. "Biomedical applications of silkworm ( Bombyx Mori ) proteins in regenerative medicine (a narrative review)." Journal of Tissue Engineering and Regenerative Medicine 16, no. 2 (2021): 91–109. http://dx.doi.org/10.1002/term.3267.

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Lee, Jung-Hwan, Ji-Young Yoon, Jun Hee Lee, Hae-Hyoung Lee, Jonathan C. Knowles, and Hae-Won Kim. "Emerging biogenesis technologies of extracellular vesicles for tissue regenerative therapeutics." Journal of Tissue Engineering 12 (January 2021): 204173142110190. http://dx.doi.org/10.1177/20417314211019015.

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Extracellular vesicles (EVs), including exosomes, carry the genetic packages of RNA, DNA, and proteins and are heavily involved in cell-cell communications and intracellular signalings. Therefore, EVs are spotlighted as therapeutic mediators for the treatment of injured and dysfunctional tissues as well as biomarkers for the detection of disease status and progress. Several key issues in EVs, including payload content and bioactivity, targeting and bio-imaging ability, and mass-production, need to be improved to enable effective therapeutics and clinical translation. For this, significant effo

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Vacchini, Mattia, Rana Edwards, Roberto Guizzardi, et al. "Glycan Carriers As Glycotools for Medicinal Chemistry Applications." Current Medicinal Chemistry 26, no. 35 (2019): 6349–98. http://dx.doi.org/10.2174/0929867326666190104164653.

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Carbohydrates are one of the most powerful and versatile classes of biomolecules that nature uses to regulate organisms’ biochemistry, modulating plenty of signaling events within cells, triggering a plethora of physiological and pathological cellular behaviors. In this framework, glycan carrier systems or carbohydrate-decorated materials constitute interesting and relevant tools for medicinal chemistry applications. In the last few decades, efforts have been focused, among others, on the development of multivalent glycoconjugates, biosensors, glycoarrays, carbohydrate-decorated biomaterials f

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Zhang, Hengtong, Xixi Wu, Liang Quan, and Qiang Ao. "Characteristics of Marine Biomaterials and Their Applications in Biomedicine." Marine Drugs 20, no. 6 (2022): 372. http://dx.doi.org/10.3390/md20060372.

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Oceans have vast potential to develop high-value bioactive substances and biomaterials. In the past decades, many biomaterials have come from marine organisms, but due to the wide variety of organisms living in the oceans, the great diversity of marine-derived materials remains explored. The marine biomaterials that have been found and studied have excellent biological activity, unique chemical structure, good biocompatibility, low toxicity, and suitable degradation, and can be used as attractive tissue material engineering and regenerative medicine applications. In this review, we give an ove

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Kapat, Kausik, Sakshi Kumbhakarn, Rahul Sable, Prashil Gondane, Shruti Takle, and Pritiprasanna Maity. "Peptide-Based Biomaterials for Bone and Cartilage Regeneration." Biomedicines 12, no. 2 (2024): 313. http://dx.doi.org/10.3390/biomedicines12020313.

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The healing of osteochondral defects (OCDs) that result from injury, osteochondritis, or osteoarthritis and bear lesions in the cartilage and bone, pain, and loss of joint function in middle- and old-age individuals presents challenges to clinical practitioners because of non-regenerative cartilage and the limitations of current therapies. Bioactive peptide-based osteochondral (OC) tissue regeneration is becoming more popular because it does not have the immunogenicity, misfolding, or denaturation problems associated with original proteins. Periodically, reviews are published on the regenerati

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Shabbir Ali, Abdallah, Rabia Gul, Halima Usman, and Faiza Naseer. "Applications of Natural Polymers in Regenerative Medicine and Tissue Engineering." Pharmaceutical Communications 2, no. 1 (2023): 47–61. http://dx.doi.org/10.55627/pharma.002.01.0299.

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Natural polymers, or biopolymers, are widely utilized in regenerative medicine and tissue engineering. These polymers, derived from proteins, polysaccharides, and nucleic acids, serve as biomaterials for scaffolds, drug delivery systems, and bioactive materials that mimic the extracellular matrix. They offer advantages such as biocompatibility, biodegradability, versatility, and integration with gene therapy. Collagen, gelatin, chitosan, hyaluronic acid, fibrin, and alginate are commonly used natural polymers in regenerative medicine. They promote cell growth, tissue formation, wound healing,

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Chilwant, Mansi, Valentina Paganini, Mariacristina Di Gangi, et al. "From Sea to Therapy: Marine Biomaterials for Drug Delivery and Wound Healing." Pharmaceuticals 18, no. 8 (2025): 1093. https://doi.org/10.3390/ph18081093.

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Marine biomass represents a valuable yet underexploited resource for the development of high-value biomaterials. Recent advances have highlighted the significant potential of marine-derived polysaccharides, proteins, and peptides in biomedical applications, most notably in drug delivery and wound healing. This review provides a comprehensive synthesis of current research on the extraction, processing and pharmaceutical valorization of these biopolymers, with a focus on their structural and functional properties that allow these materials to be engineered into nanocarriers, hydrogels, scaffolds

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Mitchell, Juan, and Kevin W. H. Lo. "The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine." Biomedicines 11, no. 9 (2023): 2507. http://dx.doi.org/10.3390/biomedicines11092507.

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Cell adhesion is essential for cell survival, communication, and regulation, and it is of fundamental importance in the development and maintenance of tissues. Cell adhesion has been widely explored due to its many important roles in the fields of tissue regenerative engineering and cell biology. This is because the mechanical interactions between a cell and its extracellular matrix (ECM) can influence and control cell behavior and function. Currently, biomaterials for regenerative medicine have been heavily investigated as substrates for promoting a cells’ adhesive properties and subsequent p

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Batool, Fareeha, Hayriye Özçelik, Céline Stutz, et al. "Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration." Journal of Tissue Engineering 12 (January 2021): 204173142110414. http://dx.doi.org/10.1177/20417314211041428.

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Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with th

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Di Francesco, Dalila, Carolina Di Varsavia, Simona Casarella, et al. "Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine." International Journal of Molecular Sciences 25, no. 2 (2024): 740. http://dx.doi.org/10.3390/ijms25020740.

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Matrix-bound nanovesicles (MBVs) are a recently discovered type of extracellular vesicles (EVs), and they are characterised by a strong adhesion to extracellular matrix structural proteins (ECM) and ECM-derived biomaterials. MBVs contain a highly bioactive and tissue-specific cargo that recapitulates the biological activity of the source ECM. The rich content of MBVs has shown to be capable of potent cell signalling and of modulating the immune system, thus the raising interest for their application in regenerative medicine. Given the tissue-specificity and the youthfulness of research on MBVs

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Rubí-Sans, Gerard, Irene Cano-Torres, Soledad Pérez-Amodio, Barbara Blanco-Fernandez, Miguel A. Mateos-Timoneda, and Elisabeth Engel. "Development and Angiogenic Potential of Cell-Derived Microtissues Using Microcarrier-Template." Biomedicines 9, no. 3 (2021): 232. http://dx.doi.org/10.3390/biomedicines9030232.

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Tissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies fail in mimicking the tissue’s extracellular matrix properties. In order to mimic native tissue conditions, we developed cell-derived matrix (CDM) microtissues (MT). Our methodology uses poly-lactic acid (PLA) and Cultispher® S microcarriers’ (MCs’) as scaffold templates, which are seeded with rat bone marrow mesenchymal stem cells (rBM-MSCs). The scaffold template allows c

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Ortiz-Arrabal, Olimpia, Ramón Carmona, Óscar-Darío García-García, et al. "Generation and Evaluation of Novel Biomaterials Based on Decellularized Sturgeon Cartilage for Use in Tissue Engineering." Biomedicines 9, no. 7 (2021): 775. http://dx.doi.org/10.3390/biomedicines9070775.

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Because cartilage has limited regenerative capability, a fully efficient advanced therapy medicinal product is needed to treat severe cartilage damage. We evaluated a novel biomaterial obtained by decellularizing sturgeon chondral endoskeleton tissue for use in cartilage tissue engineering. In silico analysis suggested high homology between human and sturgeon collagen proteins, and ultra-performance liquid chromatography confirmed that both types of cartilage consisted mainly of the same amino acids. Decellularized sturgeon cartilage was recellularized with human chondrocytes and four types of

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Davies, Rebecca, and Nicola Kuiper. "Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy." Bioengineering 6, no. 1 (2019): 22. http://dx.doi.org/10.3390/bioengineering6010022.

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Articular cartilage is composed of chondrons within a territorial matrix surrounded by a highly organized extracellular matrix comprising collagen II fibrils, proteoglycans, glycosaminoglycans, and non-collagenous proteins. Damaged articular cartilage has a limited potential for healing and untreated defects often progress to osteoarthritis. High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing progress to late osteoarthritis. One such strategy, autologous chondrocyte implantation (ACI), was first reported in 1994 as a treatment for deep focal arti

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Adachi, Tetsuya, Yoshiro Tahara, Kenta Yamamoto, et al. "Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine." Gels 10, no. 3 (2024): 206. http://dx.doi.org/10.3390/gels10030206.

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Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel structure. Nanogels have a three-dimensional network structure of cross-linked polymer chains, which have a high water content, a volume phase transition much faster than that of a macrogel, and a quick response to external stimuli. As it is possible to transmit substances according to the three-dimensional me

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Goker, Funda, Lena Larsson, Massimo Del Fabbro, and Farah Asa’ad. "Gene Delivery Therapeutics in the Treatment of Periodontitis and Peri-Implantitis: A State of the Art Review." International Journal of Molecular Sciences 20, no. 14 (2019): 3551. http://dx.doi.org/10.3390/ijms20143551.

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Background: Periodontal disease is a chronic inflammatory condition that affects supporting tissues around teeth, resulting in periodontal tissue breakdown. If left untreated, periodontal disease could have serious consequences; this condition is in fact considered as the primary cause of tooth loss. Being highly prevalent among adults, periodontal disease treatment is receiving increased attention from researchers and clinicians. When this condition occurs around dental implants, the disease is termed peri-implantitis. Periodontal regeneration aims at restoring the destroyed attachment appara

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Lindholm, T. Sam, and Tom C. Lindholm. "The Skull Defect Model in Measuring Osteoinductivity." Journal of Musculoskeletal Research 02, no. 02 (1998): 123–39. http://dx.doi.org/10.1142/s0218957798000147.

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Research on regeneration and experimental or clinical repair of cranial defects commenced already one hundred years ago. Principally spontaneous regeneration, intramembraneous bone healing, starts from the edges, proceeding to the center of the defect. A skull defect exceeding some critical limitations lacks the capacity for spontaneous healing. This kind of situation is named a "critical size" defect. The skull defect model is eminently suitable for testing osteoconduction and induction following local implantation of biomaterials and growth factors. There are numerous reports especially on o

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Narayanan, Raghuvaran, Chun-Chieh Huang, and Sriram Ravindran. "Hijacking the Cellular Mail: Exosome Mediated Differentiation of Mesenchymal Stem Cells." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3808674.

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Bone transplantation is one of the most widely performed clinical procedures. Consequently, bone regeneration using mesenchymal stem cells and tissue engineering strategies is one of the most widely researched fields in regenerative medicine. Recent scientific consensus indicates that a biomimetic approach is required to achieve proper regeneration of any tissue. Exosomes are nanovesicles secreted by cells that act as messengers that influence cell fate. Although exosomal function has been studied with respect to cancer and immunology, the role of exosomes as inducers of stem cell differentiat

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Miyata, T., and K. Kurokawa. "Carbonyl Stress: Increased Carbonyl Modification of Proteins by Autoxidation Products of Carbohydrates and Lipids in Uremia." International Journal of Artificial Organs 22, no. 4 (1999): 195–98. http://dx.doi.org/10.1177/039139889902200402.

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Zamudio-Ceja, Ruth Betsabe, Rene Garcia-Contreras, Patricia Alejandra Chavez-Granados, et al. "Decellularized Scaffolds of Nopal (Opuntia Ficus-indica) for Bioengineering in Regenerative Dentistry." Journal of Functional Biomaterials 14, no. 5 (2023): 252. http://dx.doi.org/10.3390/jfb14050252.

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Opuntia Ficus-indica, or nopal, is traditionally used for its medicinal properties in Mexico. This study aims to decellularize and characterize nopal (Opuntia Ficus-indica) scaffolds, assess their degradation and the proliferation of hDPSC, and determine potential pro-inflammatory effects by assessing the expression of cyclooxygenase 1 and 2 (COX-1 and 2). The scaffolds were decellularized using a 0.5% sodium dodecyl sulfate (SDS) solution and confirmed by color, optical microscopy, and SEM. The degradation rates and mechanical properties of the scaffolds were determined by weight and solution

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Huffer, Amelia, Mingyang Mao, Katherine Ballard, and Tugba Ozdemir. "Biomimetic Hyaluronan Binding Biomaterials to Capture the Complex Regulation of Hyaluronan in Tissue Development and Function." Biomimetics 9, no. 8 (2024): 499. http://dx.doi.org/10.3390/biomimetics9080499.

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Within native ECM, Hyaluronan (HA) undergoes remarkable structural remodeling through its binding receptors and proteins called hyaladherins. Hyaladherins contain a group of tandem repeat sequences, such as LINK domains, BxB7 homologous sequences, or 20–50 amino acid long short peptide sequences that have high affinity towards side chains of HA. The HA binding sequences are critical players in HA distribution and regulation within tissues and potentially attractive therapeutic targets to regulate HA synthesis and organization. While HA is a versatile and successful biopolymer, most HA-based th

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Chen, Jianwei, Duchao Zhou, Zhenguo Nie, et al. "A scalable coaxial bioprinting technology for mesenchymal stem cell microfiber fabrication and high extracellular vesicle yield." Biofabrication 14, no. 1 (2021): 015012. http://dx.doi.org/10.1088/1758-5090/ac3b90.

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Abstract Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are promising candidates for regenerative medicine; however, the lack of scalable methods for high quantity EV production limits their application. In addition, signature EV-derived proteins shared in 3D environments and 2D surfaces, remain mostly unknown. Herein, we present a platform combining MSC microfiber culture with ultracentrifugation purification for high EV yield. Within this platform, a high quantity MSC solution (∼3 × 108 total cells) is encapsulated in a meter-long hollow hydrogel-microfiber via coaxial biop

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Cicuéndez, Mónica, Laura Casarrubios, María José Feito, et al. "Effects of Human and Porcine Adipose Extracellular Matrices Decellularized by Enzymatic or Chemical Methods on Macrophage Polarization and Immunocompetence." International Journal of Molecular Sciences 22, no. 8 (2021): 3847. http://dx.doi.org/10.3390/ijms22083847.

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The decellularized extracellular matrix (ECM) obtained from human and porcine adipose tissue (AT) is currently used to prepare regenerative medicine bio-scaffolds. However, the influence of these natural biomaterials on host immune response is not yet deeply understood. Since macrophages play a key role in the inflammation/healing processes due to their high functional plasticity between M1 and M2 phenotypes, the evaluation of their response to decellularized ECM is mandatory. It is also necessary to analyze the immunocompetence of macrophages after contact with decellularized ECM materials to

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Tassara, Eleonora, Caterina Oliveri, Luigi Vezzulli, et al. "2D Collagen Membranes from Marine Demosponge Chondrosia reniformis (Nardo, 1847) for Skin-Regenerative Medicine Applications: An In Vitro Evaluation." Marine Drugs 21, no. 8 (2023): 428. http://dx.doi.org/10.3390/md21080428.

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Research in tissue engineering and regenerative medicine has an ever-increasing need for innovative biomaterials suitable for the production of wound-dressing devices and artificial skin-like substitutes. Marine collagen is one of the most promising biomaterials for the production of such devices. In this study, for the first time, 2D collagen membranes (2D-CMs) created from the extracellular matrix extract of the marine demosponge Chondrosia reniformis have been evaluated in vitro as possible tools for wound healing. Fibrillar collagen was extracted from a pool of fresh animals and used for t

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Xu, Zhenyuan, Jacob A. Orkwis, and Greg M. Harris. "Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases." International Journal of Molecular Sciences 22, no. 9 (2021): 4821. http://dx.doi.org/10.3390/ijms22094821.

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Schwann cells (SCs) are a highly plastic cell type capable of undergoing phenotypic changes following injury or disease. SCs are able to upregulate genes associated with nerve regeneration and ultimately achieve functional recovery. During the regeneration process, the extracellular matrix (ECM) and cell morphology play a cooperative, critical role in regulating SCs, and therefore highly impact nerve regeneration outcomes. However, the roles of the ECM and mechanotransduction relating to SC phenotype are largely unknown. Here, we describe the role that matrix stiffness and cell morphology play

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Miyamoto, Yoshitaka. "Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes." Gels 9, no. 4 (2023): 321. http://dx.doi.org/10.3390/gels9040321.

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Organ transplantation is the first and most effective treatment for missing or damaged tissues or organs. However, there is a need to establish an alternative treatment method for organ transplantation due to the shortage of donors and viral infections. Rheinwald and Green et al. established epidermal cell culture technology and successfully transplanted human-cultured skin into severely diseased patients. Eventually, artificial cell sheets of cultured skin were created, targeting various tissues and organs, including epithelial sheets, chondrocyte sheets, and myoblast cell sheets. These sheet

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Mano, J. F., G. A. Silva, H. S. Azevedo, et al. "Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends." Journal of The Royal Society Interface 4, no. 17 (2007): 999–1030. http://dx.doi.org/10.1098/rsif.2007.0220.

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The fields of tissue engineering and regenerative medicine aim at promoting the regeneration of tissues or replacing failing or malfunctioning organs, by means of combining a scaffold/support material, adequate cells and bioactive molecules. Different materials have been proposed to be used as both three-dimensional porous scaffolds and hydrogel matrices for distinct tissue engineering strategies. Among them, polymers of natural origin are one of the most attractive options, mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good bio

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Malcor, Jean-Daniel, Emma J. Hunter, Natalia Davidenko, et al. "Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture." Regenerative Biomaterials 7, no. 5 (2020): 471–82. http://dx.doi.org/10.1093/rb/rbaa025.

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Abstract Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue repair. Collagen biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered tissues. Three-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions, followed by chemical cross-linking which maintains their stability. However, cross-linking scaffolds renders their biological activity sub

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Elnour, Mohamed Salih, Samar Abdelrazeg, Rafeezul Mohamed, Manoj Lakshmanan, Kumar Sudesh, and Bakiah Shaharuddin. "Polyhydroxyalkanoate (PHA) and Wharton Jelly-mesenchymal Stem Cells (MSCs) for Corneal Regenerative Therapeutic Strategy." Malaysian Journal of Medicine and Health Sciences 20, no. 4 (2024): 235–44. https://doi.org/10.47836/mjmhs.20.4.29.

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Introduction: Corneal regenerative medicine is a contemporary approach involving the use of biomaterials, biological factors and stem cells to reduce dependence on native tissue supply for transplantation. This study aims to investigate cellularized polyhydroxyalkanoate (PHA) scaffold with human telomerase-immortalized cornea epithelial cells (HTCEC) in combination with Wharton Jelly-Mesenchymal stem cells (MSC) or its conditioned media (CM) for ocular surface regeneration. Materials and methods: The PHA employed in this investigation, P(3HB-co-4HB-co-5HV-co3HHx), was biosynthesized from Cupri

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Marín, Lina Orozco, Yuliet Montoya та John Bustamante. "Biological Evaluation of Thermosensitive Hydrogels of Chitosan/Hydrolyzed Collagen/β-GP in an In Vitro Model of Induced Cardiac Ischemia". Polymers 16, № 15 (2024): 2206. http://dx.doi.org/10.3390/polym16152206.

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Ischemic events can culminate in acute myocardial infarction, which is generated by irreversible cardiac lesions that cannot be restored due to the limited regenerative capacity of the heart. Cardiac cell therapy aims to replace injured or necrotic cells with healthy and functional cells. Tissue engineering and cardiovascular regenerative medicine propose therapeutic alternatives using biomaterials that mimic the native extracellular environment and improve cellular and tissue functionality. This investigation evaluates the effect of thermosensitive hydrogels, and murine fetal ventricular card

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Gasperini, Luca, João F. Mano, and Rui L. Reis. "Natural polymers for the microencapsulation of cells." Journal of The Royal Society Interface 11, no. 100 (2014): 20140817. http://dx.doi.org/10.1098/rsif.2014.0817.

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The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an attractive procedure for many biomedical and biotechnological applications, such as xenotransplantation, maintenance of stem cell phenotype and bioprinting of three-dimensional scaffolds for tissue engineering and regenerative medicine. In this review, we focus on naturally derived polymers that can form hydrogels under mild conditions and that are thus capable of entrapping cells within controlled volumes. Our emphasis will be on polysaccharides and proteins, including agarose, alginate, carrageenan, chi

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Dzobo, Kevin, Keolebogile Shirley Caroline M. Motaung, and Adetola Adesida. "Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review." International Journal of Molecular Sciences 20, no. 18 (2019): 4628. http://dx.doi.org/10.3390/ijms20184628.

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The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix (ECM), cells, and inductive biomolecules. Regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. The coupling of regenerative medici

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Chun, So Young, Jun Nyung Lee, Yun-Sok Ha, et al. "Optimization of extracellular matrix extraction from human perirenal adipose tissue." Journal of Biomaterials Applications 35, no. 9 (2021): 1180–91. http://dx.doi.org/10.1177/0885328220984594.

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Human adipose tissue includes useful substrates for regenerative medicine such as the extracellular matrix (ECM), but most perirenal fat tissue is wasted after kidney surgery. Since a lot of adipose tissue can be procured after a kidney, we extracted ECM from human perirenal adipose tissue and optimized the extraction process. To verify the efficacy for ECM extraction, we compared the products in several steps. Perirenal adipose tissue was either finely homogenized or underwent crude manual dissection. The amount of extracted ECM was quantified with ELISA for verification of the initial tissue

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Branković, Marija, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, and Nikola Kotorcevic. "Review of Spider Silk Applications in Biomedical and Tissue Engineering." Biomimetics 9, no. 3 (2024): 169. http://dx.doi.org/10.3390/biomimetics9030169.

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, i

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Fernandez-Medina, T., C. Vaquette, M. N. Gomez-Cerezo, and S. Ivanovski. "Characterization of the Protein Corona of Three Chairside Hemoderivatives on Melt Electrowritten Polycaprolactone Scaffolds." International Journal of Molecular Sciences 24, no. 7 (2023): 6162. http://dx.doi.org/10.3390/ijms24076162.

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In tissue engineering, the relationship between a biomaterial surface and the host’s immune response during wound healing is crucial for tissue regeneration. Despite hemoderivative functionalization of biomaterials becoming a common tissue-engineering strategy for enhanced regeneration, the characteristics of the protein–biomaterial interface have not been fully elucidated. This study characterized the interface formed by the adsorbed proteins from various hemoderivatives with pristine and calcium phosphate (CaP)-coated polycaprolactone (PCL) melt electrowritten scaffolds. PCL scaffolds were f

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Perez-Valle, Arantza, Cristina Del Amo, and Isabel Andia. "Overview of Current Advances in Extrusion Bioprinting for Skin Applications." International Journal of Molecular Sciences 21, no. 18 (2020): 6679. http://dx.doi.org/10.3390/ijms21186679.

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Bioprinting technologies, which have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, are currently being exploited for the fabrication of human skin in regenerative medicine. We performed a systematic review to appraise the latest advances in 3D bioprinting for skin applications, describing the main cell phenotypes, signaling proteins, and bioinks used in extrusion platforms. To understand the current limitations of this technology for skin bioprinting, we briefly address the relevant aspects of sk

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Markey, Miles W., Caroline D. Pena, Tadmiri Venkatesh, Li Cai, and Maribel Vazquez. "Retinal Progenitor Cells Exhibit Cadherin-Dependent Chemotaxis across Transplantable Extracellular Matrix of In Vitro Developmental and Adult Models." Journal of Tissue Engineering and Regenerative Medicine 2023 (August 24, 2023): 1–10. http://dx.doi.org/10.1155/2023/1381620.

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Retinal degeneration is an escalating public health challenge, as diseases such as age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa cause irreversible vision loss in millions of adults each year. Regenerative medicine has pioneered the development of stem cell replacement therapies, which treat degeneration by replacing damaged retinal neurons with transplanted stem-like cells (SCs). While the collective migration of SCs plays critical roles during retinal development, our understanding of collective SC behaviors within biomaterials transplanted into adult tissu

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Yeo, Giselle C., Alexey Kondyurin, Elena Kosobrodova, Anthony S. Weiss, and Marcela M. M. Bilek. "A sterilizable, biocompatible, tropoelastin surface coating immobilized by energetic ion activation." Journal of The Royal Society Interface 14, no. 127 (2017): 20160837. http://dx.doi.org/10.1098/rsif.2016.0837.

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Biomimetic materials which integrate with surrounding tissues and regulate new tissue formation are attractive for tissue engineering and regenerative medicine. Plasma immersion ion-implanted (PIII) polyethersulfone (PES) provides an excellent platform for the irreversible immobilization of bioactive proteins and peptides. PIII treatment significantly improves PES wettability and results in the formation of acidic groups on the PES surface, with the highest concentration observed at 40–80 s of PIII treatment. The elastomeric protein tropoelastin can be stably adhered to PIII-treated PES in a c

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Ilić-Stojanović, Snežana, Ljubiša Nikolić, and Suzana Cakić. "A Review of Patents and Innovative Biopolymer-Based Hydrogels." Gels 9, no. 7 (2023): 556. http://dx.doi.org/10.3390/gels9070556.

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Biopolymers represent a great resource for the development and utilization of new functional materials due to their particular advantages such as biocompatibility, biodegradability and non-toxicity. “Intelligent gels” sensitive to different stimuli (temperature, pH, ionic strength) have different applications in many industries (e.g., pharmacy, biomedicine, food). This review summarizes the research efforts presented in the patent and non-patent literature. A discussion was conducted regarding biopolymer-based hydrogels such as natural proteins (i.e., fibrin, silk fibroin, collagen, keratin, g

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Toledo, Anna L. M. M., Talita N. da Silva, Arianne C. dos S. Vaucher, et al. "Polymer Nanofibers for Biomedical Applications: Advances in Electrospinning." Current Applied Polymer Science 4, no. 3 (2021): 190–209. http://dx.doi.org/10.2174/2452271604666211122122557.

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Background: The demand for novel biomaterials has been exponentially rising in the last years as well as the searching for new technologies able to produce more efficient products in both drug delivery systems and regenerative medicine. Objective: The technique that can pretty well encompass the needs for novel and high-end materials with a relatively low-cost and easy operation is the electrospinning of polymer solutions. Methods: Electrospinning usually produces ultrathin fibers that can be applied in a myriad of biomedical devices including sustained delivery systems for drugs, proteins, bi

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Goto, Kashia, Daisuke Watanabe, Kazuki Yanagida, Tatsuya Takagi, and Akio Mizushima. "Harnessing miRNA-Containing Extracellular Vesicles from Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Regeneration of Bone Defects: A Narrative Review of Mechanisms, Biomaterials, and Clinical Translation." Cancers 17, no. 15 (2025): 2438. https://doi.org/10.3390/cancers17152438.

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We present a narrative review focusing on the therapeutic potential of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) in regenerating bone defects, particularly those resulting from surgical treatment of malignant bone and soft tissue tumors. These large bone defects pose significant challenges for reconstruction and functional recovery, highlighting the need for innovative regenerative strategies. Background: MSCs, which can differentiate into various cell types, are known for their immunosuppressive properties and ability to promote tissue repair. MSC-EVs, rich in bioactiv

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Ávila-Salas, Fabián, and Esteban F. Durán-Lara. "An Overview of Injectable Thermo-Responsive Hydrogels and Advances in their Biomedical Applications." Current Medicinal Chemistry 27, no. 34 (2020): 5773–89. http://dx.doi.org/10.2174/0929867325666190603110045.

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Background:: Injectable hydrogels are a thermo-responsive system based on biomaterials. Injectable hydrogels have been broadly investigated mainly as vehicles or scaffolds of therapeutic agents that include drugs, proteins, cells, and bioactive molecules among others, utilized in the treatment of diseases such as cancers and the repair and regeneration of tissues. Results: : There are several studies that have described the multiple features of hydrogels. However, the main aspect that breaks the paradigm in the application of hydrogels is the thermoresponsiveness that some of them have, which

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