To see the other types of publications on this topic, follow the link: Biomaterials.
Journal articles on the topic 'Biomaterials'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Biomaterials.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Ujjawal, Deepa, and Vikas Pruthi. "D-2 STUDY OF BIOFILM FORMATION ON BIOMATERIAL SURFACES(Session: Biomaterials)." Proceedings of the Asian Symposium on Materials and Processing 2006 (2006): 71. http://dx.doi.org/10.1299/jsmeasmp.2006.71.
Full text
2
Macedo Iunes Carrera, Thaisa, Lélio Fernando Ferreira Soares, Suzane Cristina Pigossi, and Priscilla Barbosa Ferreira Soares. "Assessment of knowledge of biomaterial used in periodontics among dentistry students: a cross -sectional study." Concilium 24, no. 17 (August 31, 2024): 352–66. http://dx.doi.org/10.53660/clm-3844-24r28.
Full textAbstract:
Aim: This study aimed to evaluate the degree of knowledge of biomaterials used in periodontics of dentistry undergraduate students from different semesters and universities in Brazil. Materials and Methods: The sample comprised 210 students from the fifth and tenth semesters of dentistry graduation courses. A two-part (Part I, sociodemographic items; Part II, 15 objective questions about biomaterials used in periodontics) questionnaire survey was conducted using Google Forms. Results: Most participants reported having some knowledge of biomaterials (57%), with 48% stating they had little knowledge. during graduation; were interested in biomaterials; considered feasible the use of biomaterials during the graduation course. Most students considered biomaterial use safe (97%) and specific qualification for biomaterial use to be unnecessary (58%). No statistically significant association was found between sociodemographic factors and the degree of knowledge of biomaterials. Discussion: The opportunity to work with biomaterials during graduation was associated with the degree of knowledge of biomaterials. Most participants did not have the opportunity to work with biomaterials during graduation and considered that they knew nothing or little about biomaterials. Conclusion: Based on the results, we conclude that there is a gap in theoretical and practical knowledge regarding biomaterial use in periodontics in dentistry graduation courses in Brazil.
3
Kroiča, Juta, Ingus Skadiņš, Ilze Salma, Aigars Reinis, Marina Sokolova, Dagnija Rostoka, and Natālija Bērza. "Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics / Bionoārdāmu Polimēru Saturošu Un Ar Antibiotiskajām Vielām Piesūcinātu Biomateriālu Antibakteriālās Efektivitātes Noteikšana." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 70, no. 4 (August 1, 2016): 220–26. http://dx.doi.org/10.1515/prolas-2016-0035.
Full textAbstract:
Abstract Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.
4
Susin, Cristiano, Jaebum Lee, Tiago Fiorini, Ki-Tae Koo, Peter Schüpbach, Amanda Finger Stadler, and Ulf ME Wikesjö. "Screening of Hydroxyapatite Biomaterials for Alveolar Augmentation Using a Rat Calvaria Critical-Size Defect Model: Bone Formation/Maturation and Biomaterials Resolution." Biomolecules 12, no. 11 (November 12, 2022): 1677. http://dx.doi.org/10.3390/biom12111677.
Full textAbstract:
Background: Natural (bovine-/equine-/porcine-derived) or synthetic hydroxyapatite (HA) biomaterials appear to be the preferred technologies among clinicians for bone augmentation procedures in preparation for implant dentistry. The aim of this study was to screen candidate HA biomaterials intended for alveolar ridge augmentation relative to their potential to support local bone formation/maturation and to assess biomaterial resorption using a routine critical-size rat calvaria defect model. Methods: Eighty adult male Sprague Dawley outbred rats obtained from a approved-breeder, randomized into groups of ten, were used. The calvaria defects (ø8 mm) either received sham surgery (empty control), Bio-Oss (bovine HA/reference control), or candidate biomaterials including bovine HA (Cerabone, DirectOss, 403Z013), and bovine (403Z014) or synthetic HA/ß-TCP (Reprobone, Ceraball) constructs. An 8 wk healing interval was used to capture the biomaterials’ resolution. Results: All biomaterials displayed biocompatibility. Strict HA biomaterials showed limited, if any, signs of biodegradation/resorption, with the biomaterial area fraction ranging from 22% to 42%. Synthetic HA/ß-TCP constructs showed limited evidence of biodegradation/erosion (biomaterial area fraction ≈30%). Mean linear defect closure in the sham-surgery control approximated 40%. Mean linear defect closure for the Bio-Oss reference control approximated 18% compared with 15–35% for the candidate biomaterials without significant differences between the controls and candidate biomaterials. Conclusions: None of the candidate HA biomaterials supported local bone formation/maturation beyond the native regenerative potential of this rodent model, pointing to their limitations for regenerative procedures. Biocompatibility and biomaterial dimensional stability could suggest their potential utility as long-term defect fillers.
5
Goldis, Goldis, and Chirila. "Biomaterials in Gastroenterology: A Critical Overview." Medicina 55, no. 11 (November 12, 2019): 734. http://dx.doi.org/10.3390/medicina55110734.
Full textAbstract:
In spite of the large diversity of diagnostic and interventional devices associated with gastrointestinal endoscopic procedures, there is little information on the impact of the biomaterials (metals, polymers) contained in these devices upon body tissues and, indirectly, upon the treatment outcomes. Other biomaterials for gastroenterology, such as adhesives and certain hemostatic agents, have been investigated to a greater extent, but the information is fragmentary. Much of this situation is due to the paucity of details disclosed by the manufacturers of the devices. Moreover, for most of the applications in the gastrointestinal (GI) tract, there are no studies available on the biocompatibility of the device materials when in intimate contact with mucosae and other components of the GI tract. We have summarized the current situation with a focus on aspects of biomaterials and biocompatibility related to the device materials and other agents, with an emphasis on the GI endoscopic procedures. Procedures and devices used for the control of bleeding, for polypectomy, in bariatrics, and for stenting are discussed, particularly dwelling upon the biomaterial-related features of each application. There are indications that research is progressing steadily in this field, and the establishment of the subdiscipline of “gastroenterologic biomaterials” is not merely a remote projection. Upon the completion of this article, the gastroenterologist should be able to understand the nature of biomaterials and to achieve a suitable and beneficial perception of their significance in gastroenterology. Likewise, the biomaterialist should become aware of the specific tasks that the biomaterials must fulfil when placed within the GI tract, and regard such applications as both a challenge and an incentive for progressing the research in this field.
6
Uthai, Wichai, Kreunate Jittiporn, PongThanya Pongsuda, and Aumnate Chuanchom. "D-5 BIOMATERIAL INDICATOR FOR PATHOGEN SAFE IN FERMENTED PRODUCTS(Session: Biomaterials)." Proceedings of the Asian Symposium on Materials and Processing 2006 (2006): 74. http://dx.doi.org/10.1299/jsmeasmp.2006.74.
Full text
7
Atheena, Milagi Pandian S., Murugan Rashika, M. Sudherson, and Sakthi M. Kriya. "Biomaterial strategies for immune system enhancement and tissue healing." i-manager’s Journal on Future Engineering and Technology 20, no. 1 (2024): 1. https://doi.org/10.26634/jfet.20.1.21086.
Full textAbstract:
Recent biomaterials like nanoparticles, graphene, and functional hydrogels are advancing tissue engineering and disease therapy through immunomodulation, tissue regeneration, and cancer therapy. This study explores the role of biomaterials in enhancing immune responses and promoting tissue regeneration. Implantable biomaterials offer innovative therapeutic effects in various disease situations. Understanding the interactions between biomaterials and host cells is crucial for creating therapeutic biomaterials that facilitate tissue integration and mitigate foreign body reactions. This study emphasizes how biomaterial properties, like size, shape, surface composition, and mechanical characteristics, influence immune cell responses, particularly macrophage polarization, which is crucial for minimizing inflammation and supporting tissue repair. The findings underscore the importance of tailored biomaterial design to mitigate foreign body reactions, improve biocompatibility, and ultimately enhance patient outcomes.
8
Ramesh, B., Anandhi R J, Vanya Arun, Atul Singla, Pradeep Kumar Chandra, Vandana Arora Sethi, and Ahmed Salam Abood. "A Review on Biomaterials for Neural Interfaces: Enhancing Brain-Machine Interfaces." E3S Web of Conferences 505 (2024): 01005. http://dx.doi.org/10.1051/e3sconf/202450501005.
Full textAbstract:
Biomaterials are essential to the development of neural interfaces, including brainmachine interfaces. Biomaterial methods improve neural interface functionality, compatibility, and longevity, enabling brain-device communication. An extensive investigation of biomaterials utilized in brain electrode arrays, neural probes, & implantable devices rely on how materials affect neural signals recording, stimulation, & tissue contact. It also investigates how biomaterials, bioelectronics and 3D printing could improve neural interfaces. Biomaterials modulate neuroinflammatory responses, enhance brain tissue regeneration, and promote neural interface longevity. This study shows the potential for change of biomaterial-based neural interfaces in neuroprosthetics, neurological rehabilitation, and fundamental neuroscience research, addressing the need for brain-machine relationship and neurotechnology innovation. These findings suggest expanding biomaterials research and development to advance and sustain neural interface technologies for future use.
9
Courtney, J. M., L. Irvine, C. Jones, S. M. Mosa, L. M. Robertson, and S. Srivastava. "Biomaterials in Medicine - A Bioengineering Perspective." International Journal of Artificial Organs 16, no. 3 (March 1993): 164–71. http://dx.doi.org/10.1177/039139889301600311.
Full textAbstract:
Biomaterials are considered with an emphasis on those used in artificial organs. Attention is drawn to the importance of the polymeric biomaterials and factors which affect their properties. Functions of membranes, sorbents, blood tubing, ventricular diaphragms and cell culture substrates are examined in order to obtain a summary of fundamental properties. Observations are made on the importance of blood compatibility assessment and its association with a biomaterial structure-property relationship. Blood-biomaterial interactions are discussed in terms of an overall relationship between the three components –- blood, biomaterial and antithrombotic agent, with examples given of factors influencing each component. Cell-biomaterial interactions are examined in the areas of toxicity evaluation and the promotion of cell attachment and growth, where an overall relationship is described for the cell, growth medium and growth factors, and the biomaterial acting as a substrate.
10
Lu, Tao, Yuqin Qiao, and Xuanyong Liu. "Surface modification of biomaterials using plasma immersion ion implantation and deposition." Interface Focus 2, no. 3 (March 21, 2012): 325–36. http://dx.doi.org/10.1098/rsfs.2012.0003.
Full textAbstract:
Although remarkable progress has been made on biomaterial research, the ideal biomaterial that satisfies all the technical requirements and biological functions is not available up to now. Surface modification seems to be a more economic and efficient way to adjust existing conventional biomaterials to meet the current and ever-evolving clinical needs. From an industrial perspective, plasma immersion ion implantation and deposition (PIII&D) is an attractive method for biomaterials owing to its capability of treating objects with irregular shapes, as well as the control of coating composition. It is well acknowledged that the physico-chemical characteristics of biomaterials are the decisive factors greatly affecting the biological responses of biomaterials including bioactivity, haemocompatibility and antibacterial activity. Here, we mainly review the recent advances in surface modification of biomaterials via PIII&D technology, especially titanium alloys and polymers used for orthopaedic, dental and cardiovascular implants. Moreover, the variations of biological performances depending on the physico-chemical properties of modified biomaterials will be discussed.
11
Gokcekuyu, Yasemin, Fatih Ekinci, Mehmet Serdar Guzel, Koray Acici, Sahin Aydin, and Tunc Asuroglu. "Artificial Intelligence in Biomaterials: A Comprehensive Review." Applied Sciences 14, no. 15 (July 28, 2024): 6590. http://dx.doi.org/10.3390/app14156590.
Full textAbstract:
The importance of biomaterials lies in their fundamental roles in medical applications such as tissue engineering, drug delivery, implantable devices, and radiological phantoms, with their interactions with biological systems being critically important. In recent years, advancements in deep learning (DL), artificial intelligence (AI), machine learning (ML), supervised learning (SL), unsupervised learning (UL), and reinforcement learning (RL) have significantly transformed the field of biomaterials. These technologies have introduced new possibilities for the design, optimization, and predictive modeling of biomaterials. This review explores the applications of DL and AI in biomaterial development, emphasizing their roles in optimizing material properties, advancing innovative design processes, and accurately predicting material behaviors. We examine the integration of DL in enhancing the performance and functional attributes of biomaterials, explore AI-driven methodologies for the creation of novel biomaterials, and assess the capabilities of ML in predicting biomaterial responses to various environmental stimuli. Our aim is to elucidate the pivotal contributions of DL, AI, and ML to biomaterials science and their potential to drive the innovation and development of superior biomaterials. It is suggested that future research should further deepen these technologies’ contributions to biomaterials science and explore new application areas.
12
Ayasaka, Kentaro, Mrunalini Ramanathan, Ngo Xuan Huy, Ankhtsetseg Shijirbold, Tatsuo Okui, Hiroto Tatsumi, Tatsuhito Kotani, Yukiho Shimamura, Reon Morioka, and Takahiro Kanno. "Evaluation of Hard and Soft Tissue Responses to Four Different Generation Bioresorbable Materials-Poly-l-Lactic Acid (PLLA), Poly-l-Lactic Acid/Polyglycolic Acid (PLLA/PGA), Uncalcined/Unsintered Hydroxyapatite/Poly-l-Lactic Acid (u-HA/PLLA) and Uncalcined/Unsintered Hydroxyapatite/Poly-l-Lactic Acid/Polyglycolic Acid (u-HA/PLLA/PGA) in Maxillofacial Surgery: An In-Vivo Animal Study." Materials 16, no. 23 (November 27, 2023): 7379. http://dx.doi.org/10.3390/ma16237379.
Full textAbstract:
Bone stabilization using osteosynthesis devices is essential in maxillofacial surgery. Owing to numerous disadvantages, bioresorbable materials are preferred over titanium for osteofixation in certain procedures. The biomaterials used for osteosynthesis in maxillofacial surgery have been subdivided into four generations. No study has compared the tissue responses generated by four generations of biomaterials and the feasibility of using these biomaterials in different maxillofacial surgeries. We conducted an in vivo animal study to evaluate host tissue response to four generations of implanted biomaterial sheets, namely, PLLA, PLLA/PGA, u-HA/PLLA, and u-HA/PLLA/PGA. New bone volume and pertinent biomarkers for bone regeneration, such as Runx2, osteocalcin (OCN), and the inflammatory marker CD68, were analyzed, and the expression of each biomarker was correlated with soft tissues outside the biomaterial and toward the host bone at the end of week 2 and week 10. The use of first-generation biomaterials for maxillofacial osteosynthesis is not advantageous over the use of other updated biomaterials. Second-generation biomaterials degrade faster and can be potentially used in non-stress regions, such as the midface. Third and fourth-generation biomaterials possess bioactive/osteoconductivity improved strength. Application of third-generation biomaterials can be considered panfacially. Fourth-generation biomaterials can be worth considering applying at midface due to the shorter degradation period.
13
Kret, Paulina, Anna Bodzon-Kulakowska, Anna Drabik, Joanna Ner-Kluza, Piotr Suder, and Marek Smoluch. "Mass Spectrometry Imaging of Biomaterials." Materials 16, no. 18 (September 21, 2023): 6343. http://dx.doi.org/10.3390/ma16186343.
Full textAbstract:
The science related to biomaterials and tissue engineering accounts for a growing part of our knowledge. Surface modifications of biomaterials, their performance in vitro, and the interaction between them and surrounding tissues are gaining more and more attention. It is because we are interested in finding sophisticated materials that help us to treat or mitigate different disorders. Therefore, efficient methods for surface analysis are needed. Several methods are routinely applied to characterize the physical and chemical properties of the biomaterial surface. Mass Spectrometry Imaging (MSI) techniques are able to measure the information about molecular composition simultaneously from biomaterial and adjacent tissue. That is why it can answer the questions connected with biomaterial characteristics and their biological influence. Moreover, this kind of analysis does not demand any antibodies or dyes that may influence the studied items. It means that we can correlate surface chemistry with a biological response without any modification that could distort the image. In our review, we presented examples of biomaterials analyzed by MSI techniques to indicate the utility of SIMS, MALDI, and DESI—three major ones in the field of biomaterials applications. Examples include biomaterials used to treat vascular system diseases, bone implants with the effects of implanted material on adjacent tissues, nanofibers and membranes monitored by mass spectrometry-related techniques, analyses of drug-eluting long-acting parenteral (LAPs) implants and microspheres where MSI serves as a quality control system.
14
Sanyal, Arka, Anushikha Ghosh, Chandrashish Roy, Ishanee Mazumder, and Pasquale Marrazzo. "Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization." Journal of Functional Biomaterials 14, no. 7 (July 4, 2023): 352. http://dx.doi.org/10.3390/jfb14070352.
Full textAbstract:
The field of biomedical engineering highly demands technological improvements to allow the successful engraftment of biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one of the primary suitable materials employed and functionalized to enhance their biocompatibility and thus confer advantageous features after graft implantation. Incorporating bioactive substances from nature is a good technique for expanding or increasing the functionality of biomaterial scaffolds, which may additionally encourage tissue healing. Our ecosystem provides natural resources, like honeybee products, comprising a rich blend of phytochemicals with interesting bioactive properties, which, when functionally coupled with biomedical biomaterials, result in the biomaterial exhibiting anti-inflammatory, antimicrobial, and antioxidant effects. Bee pollen is a sustainable product recently discovered as a new functionalizing agent for biomaterials. This review aims to articulate the general idea of using honeybee products for biomaterial engineering, mainly focusing on describing recent literature on experimental studies on biomaterials functionalized with bee pollen. We have also described the underlying mechanism of the bioactive attributes of bee pollen and shared our perspective on how future biomedical research will benefit from the fabrication of such functionalized biomaterials.
15
Boffito, Monica, and Gianluca Ciardelli. "Biomaterials Tailoring at the Nanoscale for Tissue Engineering and Advanced Therapies." Nanomaterials 11, no. 5 (May 6, 2021): 1221. http://dx.doi.org/10.3390/nano11051221.
Full textAbstract:
The definition of the term “biomaterial” dates back to 1991, during the 2nd Consensus Conference on the Definitions in Biomaterials organized by the European Society of Biomaterials in Chester (UK) [...]
16
Shymanskyi, Volodymyr, and Yaroslav Sokolovskyy. "Finite Element Calculation of the Linear Elasticity Problem for Biomaterials with Fractal Structure." Open Bioinformatics Journal 14, no. 1 (November 19, 2021): 114–22. http://dx.doi.org/10.2174/18750362021140100114.
Full textAbstract:
Aims: The aim of this study was to develop the mathematical models of the linear elasticity theory of biomaterials by taking into account their fractal structure. This study further aimed to construct a variational formulation of the problem, obtain the main relationships of the finite element method to calculate the rheological characteristics of a biomaterial with a fractal structure, and develop application software for calculating the components of the stress-strain state of biomaterials while considering their fractal structure. The obtained results were analyzed. Background: The development of adequate mathematical models of the linear elasticity theory for biomaterials with a fractal structure is an urgent scientific task. Finding its solution will make it possible to analyze the rheological behavior of biomaterials exposed to external loads by taking into account the existing effects of memory, spatial non-locality, self-organization, and deterministic chaos in the material. Objective: The objective of this study was the deformation process of biomaterials with a fractal structure under external load. Methods: The equations of the linear elasticity theory for the construction of the mathematical models of the deformation process of biomaterials under external load were used. Mathematical apparatus of integro-differentiation of fractional order to take into account the fractal structure of the biomaterial was used. A variational formulation of the linear elasticity problem while taking into account the fractal structure of the biomaterial was formulated. The finite element method with a piecewise linear basis for finding an approximate solution to the problem was used. Results: The main relations of the linear elasticity problem, which takes into account the fractal structure of the biomaterial, were obtained. A variational formulation of the problem was constructed. The main relations of the finite-element calculation of the linear elasticity problem of a biomaterial with a fractal structure using a piecewise-linear basis are found. The main components of the stress-strain state of the biomaterial exposed to external loads are found. Conclusion: Using the mathematical apparatus of integro-differentiation of fractional order in the construction of the mathematical models of the deformation process of biomaterials with a fractal structure makes it possible to take into account the existing effects of memory, spatial non-locality, self-organization, and deterministic chaos in the material. Also, this approach makes it possible to determine the residual stresses in the biomaterial, which play an important role in the appearance of stresses during repeated loads.
17
Ratner, Buddy D., Anne B. Johnston, and Thomas J. Lenk. "Biomaterial surfaces." Journal of Biomedical Materials Research 21, S1 (April 1987): 59–89. http://dx.doi.org/10.1002/j.1097-4636.1987.tb00005.x.
Full textAbstract:
The nature of a biomaterial surface governs the processes involved in biological response. Surface properties such as surface chemistry, surface energy, and morphology may be measured in order to understand the surface region of a biomaterial. In this article, we describe the surface characteristics of a few common biomaterials, review the techniques used to measure surface properties, and discuss the application of surface information in developing novel and improved biomaterials.
18
Skadiņš, Ingus, Juta Kroiča, Ilze Salma, Aigars Reinis, Marina Sokolova, and Dagnija Rostoka. "The Level of Inflammatory Cytokines and Antimicrobial Peptides after Composite Material Implantation and Contamination with Bacterial Culture." Key Engineering Materials 721 (December 2016): 245–50. http://dx.doi.org/10.4028/www.scientific.net/kem.721.245.
Full textAbstract:
As biomaterial implantation is a traumatic process, especially if the implanted object becomes contaminated by bacteria, it can cause a significant increase in the production of inflammatory cytokines. An increase in the level of inflammatory cytokines can be used as a marker of biomaterial associated infection (BAI) in surrounding tissues. To prevent BAI and production of inflammatory cytokines, biomaterials with antibiotics should be used, in particular biomaterials with prolonged release of antibiotics. In this in vivo study, the level of inflammatory cytokines (interleukine – 10 (IL-10), beta-defensin-2 and tumor necrosis factors (TNF-alpha)) was determined in surrounding tissues after composite material implantation in vivo and wound contamination with Staphylococcus epidermidis (S. epidermidis) or Pseudomonas aeruginosa (P. aeruginosa). The results show that the level of inflammatory cytokines is normal in surrounding tissues after implantation of biomaterials with prolonged release of antibiotics. Biomaterials with rapid release of antibiotics also show normal levels of inflammatory cytokines. The level of inflammatory cytokines increases in cases if biomaterials without antibiotics are implanted in vivo, thus being an indication of inflammation process and BAI.
19
Reinis, Aigars, Māra Pilmane, Agnese Stunda, Jānis Vētra, Juta Kroiča, Dagnija Rostoka, Ģirts Šalms, Antons Vostroilovs, Aleksejs Dons, and Līga Bērziņa-Cimdiņa. "An In Vitro and In Vivo Study on the Intensity of Adhesion and Colonization by Staphylococcus epidermidis and Pseudomonas aeruginosa on Originally Synthesized Biomaterials With Different Chemical Composition and Modified Surfaces and Their Effect on Expression of TNF-α, β-Defensin 2 and IL-10 in Tissues." Medicina 47, no. 10 (November 5, 2011): 80. http://dx.doi.org/10.3390/medicina47100080.
Full textAbstract:
The aim of this study was to determine adhesion and colonization of bacteria on the surface of originally synthesized glass-ceramic biomaterials and their effect on inflammation reactions in tissues surrounding the implant. Materials and Methods. Biomaterial discs were contaminated with bacterial suspensions of 10, 102, and 103 colony forming units (CFU)/mL (P. aeruginosa ATCC 27853 and S. epidermidis ATCC 12228), and after 2 hours of cultivation, the intensity of bacterial adhesion was determined. For in vivo tests, the samples were contaminated with 102 and 103 CFU/mL cultivated at 37oC for 2 h to ensure bacterial adhesion. Contaminated biomaterial samples were implanted in the interscapular area of chinchilla rabbits for 2 and 4 weeks. The biomaterials were removed, and using plate count and sonification methods, bacterial colonization on the surface of biomaterials was determined. Moreover, the expression of TNF-α, β-defensin 2, and IL-10 in the surrounding tissues was assessed by using immunohistochemistry methods. Results. P. aeruginosa more intensively colonized biomaterials in the in vivo study as compared with S. epidermidis. Il-10 is a regulatory cytokine, which reduces the intensity of inflammatory cell activity, thus reducing nonspecific resistance of the organism. Conclusions. The expression of TNF-α and IL-10 was not affected by short (2 and 4 weeks) biomaterial implantation. Pronounced cytokine expression in tissues around implanted biomaterials contaminated with P. aeruginosa was observed.
20
Gottenbos, B., F. Klatter, H. C. Van Der Mei, H. J. Busscher, and P. Nieuwenhuis. "Late Hematogenous Infection of Subcutaneous Implants in Rats." Clinical Diagnostic Laboratory Immunology 8, no. 5 (September 1, 2001): 980–83. http://dx.doi.org/10.1128/cdli.8.5.980-983.2001.
Full textAbstract:
ABSTRACT Late biomaterial-centered infection is a major complication associated with the use of biomaterial implants. In this study biomaterials that had been implanted subcutaneously in rats were hematogenously challenged with bacteria 4 weeks after implantation. Bacteria were spread either by intravenous injection or by stimulation of bacterial translocation. It was found that none of the biomaterials was infected by hematogenous spread, whereas 5% of the implants were infected by perioperative contamination. We conclude that late hematogenous infection of subcutaneous biomaterials does not occur in the rat. For humans as well, there are growing doubts whether implants actually become infected through hematogenous routes; it is thought that late infections may be caused by delayed appearance of perioperatively introduced bacteria.
21
BALTATU, Madalina Simona, Petrica VIZUREANU, Andrei Victor SANDU, Iustinian BALTATU, Doru Dumitru BURDUHOS-NERGIS, and Marcelin BENCHEA. "PROSPECTS ON TITANIUM BIOMATERIALS." European Journal of Materials Science and Engineering 8, no. 4 (December 20, 2023): 201–12. http://dx.doi.org/10.36868/ejmse.2023.08.04.201.
Full textAbstract:
Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either a therapeutic or diagnostic one. Biomaterials have a rich history of evolution, as they have continuously transformed from simple inert substances to complex, interactive materials, designed to communicate with biological systems and promote tissue regeneration and healing. Titanium, due to its excellent biocompatibility, corrosion resistance, and mechanical properties, has established its place as one of the most used biomaterials, particularly in orthopedics and dental applications. This article provides an overview of titanium as a biomaterial, highlighting its properties, applications, and recent advancements.
22
Bonini, Fabien, Sébastien Mosser, Flavio Maurizio Mor, Anissa Boutabla, Patrick Burch, Amélie Béduer, Adrien Roux, and Thomas Braschler. "The Role of Interstitial Fluid Pressure in Cerebral Porous Biomaterial Integration." Brain Sciences 12, no. 4 (March 22, 2022): 417. http://dx.doi.org/10.3390/brainsci12040417.
Full textAbstract:
Recent advances in biomaterials offer new possibilities for brain tissue reconstruction. Biocompatibility, provision of cell adhesion motives and mechanical properties are among the present main design criteria. We here propose a radically new and potentially major element determining biointegration of porous biomaterials: the favorable effect of interstitial fluid pressure (IFP). The force applied by the lymphatic system through the interstitial fluid pressure on biomaterial integration has mostly been neglected so far. We hypothesize it has the potential to force 3D biointegration of porous biomaterials. In this study, we develop a capillary hydrostatic device to apply controlled in vitro interstitial fluid pressure and study its effect during 3D tissue culture. We find that the IFP is a key player in porous biomaterial tissue integration, at physiological IFP levels, surpassing the known effect of cell adhesion motives. Spontaneous electrical activity indicates that the culture conditions are not harmful for the cells. Our work identifies interstitial fluid pressure at physiological negative values as a potential main driver for tissue integration into porous biomaterials. We anticipate that controlling the IFP level could narrow the gap between in vivo and in vitro and therefore decrease the need for animal screening in biomaterial design.
23
Sorg, Heiko, Daniel J. Tilkorn, Jörg Hauser, and Andrej Ring. "Improving Vascularization of Biomaterials for Skin and Bone Regeneration by Surface Modification: A Narrative Review on Experimental Research." Bioengineering 9, no. 7 (July 4, 2022): 298. http://dx.doi.org/10.3390/bioengineering9070298.
Full textAbstract:
Artificial tissue substitutes are of great interest for the reconstruction of destroyed and non-functional skin or bone tissue due to its scarcity. Biomaterials used as scaffolds for tissue regeneration are non-vascularized synthetic tissues and often based on polymers, which need ingrowth of new blood vessels to ensure nutrition and metabolism. This review summarizes previous approaches and highlights advances in vascularization strategies after implantation of surface-modified biomaterials for skin and bone tissue regeneration. The efficient integration of biomaterial, bioactive coating with endogenous degradable matrix proteins, physiochemical modifications, or surface geometry changes represents promising approaches. The results show that the induction of angiogenesis in the implant site as well as the vascularization of biomaterials can be influenced by specific surface modifications. The neovascularization of a biomaterial can be supported by the application of pro-angiogenic substances as well as by biomimetic surface coatings and physical or chemical surface activations. Furthermore, it was confirmed that the geometric properties of the three-dimensional biomaterial matrix play a central role, as they guide or even enable the ingrowth of blood vessels into a biomaterial.
24
Nii, Teruki, and Yoshiki Katayama. "Biomaterial-Assisted Regenerative Medicine." International Journal of Molecular Sciences 22, no. 16 (August 12, 2021): 8657. http://dx.doi.org/10.3390/ijms22168657.
Full textAbstract:
This review aims to show case recent regenerative medicine based on biomaterial technologies. Regenerative medicine has arousing substantial interest throughout the world, with “The enhancement of cell activity” one of the essential concepts for the development of regenerative medicine. For example, drug research on drug screening is an important field of regenerative medicine, with the purpose of efficient evaluation of drug effects. It is crucial to enhance cell activity in the body for drug research because the difference in cell condition between in vitro and in vivo leads to a gap in drug evaluation. Biomaterial technology is essential for the further development of regenerative medicine because biomaterials effectively support cell culture or cell transplantation with high cell viability or activity. For example, biomaterial-based cell culture and drug screening could obtain information similar to preclinical or clinical studies. In the case of in vivo studies, biomaterials can assist cell activity, such as natural healing potential, leading to efficient tissue repair of damaged tissue. Therefore, regenerative medicine combined with biomaterials has been noted. For the research of biomaterial-based regenerative medicine, the research objective of regenerative medicine should link to the properties of the biomaterial used in the study. This review introduces regenerative medicine with biomaterial.
25
Kim, Alexia, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, and Michelle Griffin. "Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response." Bioengineering 10, no. 12 (December 11, 2023): 1411. http://dx.doi.org/10.3390/bioengineering10121411.
Full textAbstract:
Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the complex biomaterial–host cell interactions that occur within the tissue microenvironment is crucial for the development of therapeutic biomaterials that promote tissue integration and minimize the foreign body response. Recent modifications of specific material properties enhance the immunomodulatory capabilities of the biomaterial and actively aid in taming the immune response by tuning interactions with the surrounding microenvironment either directly or indirectly. By incorporating modifications that amplify anti-inflammatory and pro-regenerative mechanisms, biomaterials can be optimized to maximize their healing benefits in harmony with the host immune system.
26
Macnair, R., M. J. Underwood, and G. D. Angelini. "Biomaterials and cardiovascular devices." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 6 (June 1, 1998): 465–71. http://dx.doi.org/10.1243/0954411981534222.
Full textAbstract:
In the field of cardiovascular surgery there is presently a lack of biomaterials possessing essential characteristics of the native tissue or organ which is to be replaced. This paper describes various biomaterials that have been introduced into the circulatory system and the complex reactions that subsequently occur. The risk of infection is also discussed as well as prevention and treatment regimes that can be used. Examples of future biomaterial development are outlined in an attempt to achieve biocompatibility.
27
Savin, Liliana, Tudor Pinteala, Dana Nicoleta Mihai, Dan Mihailescu, Smaranda Stefana Miu, Mihnea Theodor Sirbu, Bogdan Veliceasa, Dragos Cristian Popescu, Paul Dan Sirbu, and Norin Forna. "Updates on Biomaterials Used in Total Hip Arthroplasty (THA)." Polymers 15, no. 15 (August 2, 2023): 3278. http://dx.doi.org/10.3390/polym15153278.
Full textAbstract:
One of the most popular and effective orthopedic surgical interventions for treating a variety of hip diseases is total hip arthroplasty. Despite being a radical procedure that involves replacing bone and cartilaginous surfaces with biomaterials, it produces excellent outcomes that significantly increase the patient’s quality of life. Patient factors and surgical technique, as well as biomaterials, play a role in prosthetic survival, with aseptic loosening (one of the most common causes of total hip arthroplasty failure) being linked to the quality of biomaterials utilized. Over the years, various biomaterials have been developed to limit the amount of wear particles generated over time by friction between the prosthetic head (metal alloys or ceramic) and the insert fixed in the acetabular component (polyethylene or ceramic). An ideal biomaterial must be biocompatible, have a low coefficient of friction, be corrosion resistant, and have great mechanical power. Comprehensive knowledge regarding what causes hip arthroplasty failure, as well as improvements in biomaterial quality and surgical technique, will influence the survivability of the prosthetic implant. The purpose of this article was to assess the benefits and drawbacks of various biomaterial and friction couples used in total hip arthroplasties by reviewing the scientific literature published over the last 10 years.
28
Skadiņš, Ingus, Juta Kroiča, Ilze Salma, Aigars Reinis, Marina Sokolova, and Dagnija Rostoka. "Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 73, no. 2 (May 1, 2019): 177–84. http://dx.doi.org/10.2478/prolas-2019-0028.
Full textAbstract:
Abstract Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In this in vitro study, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa was studied by evaluating the expression of inflammatory cytokines (Interleukin-10 (IL-10), -defensin-2 and tumour necrosis factor alpha (TNF- )) in tissue surrounding implanted biomaterials in vivo. The results of this study demonstrated that hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers had a prolonged antibacterial effect in comparison to biomaterials without biodegradable polymers. Surrounding tissue displayed higher levels of inflammatory cytokines when implanted biomaterials had not been previously impregnated with antibiotics.
29
Leeuwenburgh, Sander. "Self-healing biomaterials for medical applications." MATEC Web of Conferences 378 (2023): 01003. http://dx.doi.org/10.1051/matecconf/202337801003.
Full textAbstract:
Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties are required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing in order to improve the functionality of traditional biomaterials in terms of their mechanical, handling and biological properties. This presentation will provide a comprehensive overview of the field of self-healing biomaterials, ranging from self-healing of capsule-filled dental fillers and bone cements, to the self-healing behavior of modern injectable hydrogels used in regenerative medicine. More specifically, the presentation will highlight why self-healing properties of biomaterials are crucial for minimally invasive injection into the human body and achieve successful tissue regeneration.
30
de Kanter, Anne-Floor J., Karin R. Jongsma, and Annelien L. Bredenoord. "How Smart are Smart Materials? A Conceptual and Ethical Analysis." Studia Universitatis Babeş-Bolyai Bioethica 66, Special Issue (September 9, 2021): 64. http://dx.doi.org/10.24193/subbbioethica.2021.spiss.36.
Full textAbstract:
"Today, a person can receive a hip implant to replace a deformed, swollen hip joint or a pacemaker to sustain the beating rhythm of their heart. Thanks to Regenerative Medicine, soon, it may become possible not just to replace, but to re-grow healthy tissues after injury or disease. To this end, tissue engineers are designing ‘smart’, ‘life-like’ biomaterial implants to activate the inherent regenerative capacity of the human body. Such a smart life-like biomaterial may for example stimulate re-growth of a fresh, living heart valve after implantation in a patient’s heart. However, the meaning of the smartness and lifelikeness of these synthetic biomaterials is conceptually unclear. Therefore, in this paper, we first aim to unravel the meaning of the terms ‘smart’ and ‘life-like’, and next, analyse what ethical and societal implications are associated with this new generation of biomaterial implants as a result. Our conceptual analysis reveals that the biomaterials are considered ‘smart’ because they can communicate with human tissues and ‘life-like’ because they are structurally similar to these tissues. Moreover, the biomaterial artifacts are designed to integrate to a high degree with the living tissue of the human body. While these characteristics provide the biomaterials with their therapeutic potential, we argue that it complicates a) the irreversibility of the implantation process, b) questions of ownership regarding the biomaterial implant, and c) the sense of embodiment of the receiver of the implant. Overall, timely anticipation and consideration of these ethical challenges will promote responsible development of biomaterials in Regenerative Medicine. "
31
Mahdi, Nour Muhammad Salih, Ayad K. Hassan, Fatima J. Al-Hasani, and Waleed Ameen Mahmoud Al-Jawher. "Classification Of Biomaterials and Their Applications." Journal Port Science Research 7, no. 3 (August 12, 2024): 281–99. http://dx.doi.org/10.36371/port.2024.3.7.
Full textAbstract:
Biomaterials, designed to interact with living systems, play a vital role in various medical applications. Classifying these materials effectively is crucial for understanding their properties and ensuring optimal use. Biomaterials are classified based on their chemical composition, structure, and properties relevant for biological applications. In this paper five types of Biomaterials classification methods are given namely. Chemical, Functional, Source of biomaterials, Structural and Smart levels classification. Each of these five-biomaterial classification method offers unique advantages and disadvantages. Chemical Classification is simple and well-established method, easy to understand and interpret and provides a basic framework for material identification. Functional Classification is directly related to the application of the biomaterial, provides insight into the desired material properties and useful for identifying materials for specific therapeutic needs. Source-Based Classification is straightforward method based on material origin and can be useful for initial categorization and understanding general material properties (e.g., natural materials often biocompatible). Structural Classification provides information about material properties like strength, degradation, and permeability and can be relevant for understanding biocompatibility and material performance. Smart Level Classification captures the advanced functionalities of next-generation biomaterials, provides insights into targeted drug delivery or controlled cell interactions and useful for identifying materials for specific therapeutic applications. The most suitable method depends on the specific context and information needs.
32
Ruth, Serunjogi. "Cytokine Modulation with Biomaterials: Engineering the Immune Response for Tissue Repair and Regeneration." Research Output Journal of Public Health and Medicine 4, no. 3 (December 4, 2024): 37–41. https://doi.org/10.59298/rojphm/2024/433741.
Full textAbstract:
Cytokines are key regulators of the immune response and play critical roles in tissue repair and regeneration. Modulating the cytokine environment at sites of injury can improve healing by reducing chronic inflammation and promoting tissue remodeling. Biomaterials have emerged as effective platforms for delivering cytokines in a controlled and localized manner, providing spatial and temporal regulation of the immune response. This review discusses various biomaterial-based strategies for cytokine modulation, including hydrogels, nanoparticles, and scaffolds, each designed to influence immune cell behavior and enhance tissue regeneration. Biomaterials can be engineered to deliver specific cytokines, such as interleukin-10 (IL-10) or transforming growth factor-beta (TGF-β), which help suppress inflammation and promote the differentiation of stem cells or other progenitor cells. Applications of cytokine-modulating biomaterials in wound healing, bone regeneration, cardiac repair, and nerve regeneration are explored. Additionally, challenges such as achieving precise cytokine release, maintaining cytokine stability, and the complexity of immune regulation are addressed. Advances in biomaterial design hold great potential for developing “smart” systems capable of adjusting cytokine delivery based on the evolving tissue environment. The use of cytokine-modulating biomaterials represents a promising approach to improving clinical outcomes in regenerative medicine and tissue engineering. Keywords: Cytokine modulation, Biomaterial, Tissue regeneration, Immune response, Inflammation, Controlled release
33
Batool, Fareeha, Hayriye Özçelik, Céline Stutz, Pierre-Yves Gegout, Nadia Benkirane-Jessel, Catherine Petit, and Olivier Huck. "Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration." Journal of Tissue Engineering 12 (January 2021): 204173142110414. http://dx.doi.org/10.1177/20417314211041428.
Full textAbstract:
Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.
34
Bedini, Rossella, Deborah Meleo, and Raffaella Pecci. "3D Microtomography Characterization of Dental Implantology Bone Substitutes Used In Vivo." Key Engineering Materials 541 (February 2013): 97–113. http://dx.doi.org/10.4028/www.scientific.net/kem.541.97.
Full textAbstract:
After a short introduction to bone substitute biomaterials and X-ray microtomography, this article describes a research work carried out for in-vitro characterization of bone substitute biomaterials as well as for in-vivo investigation of human bone grafted with biomaterials. Three different bone substitute biomaterials have been analyzed in-vitro by means of 3D microtomographic technique, while human bone samples grafted with bone substitute biomaterials are investigated by 3D microtomography and histological techniques. 3D images of bone substitutes and human bone samples with biomaterials have been obtained, together with morphometric parameters, by microtomography . 2D histological images have also been obtained by traditional technique only for human bone samples with biomaterials. Compared to traditional histological analysis, 3D microtomography shows better results for investigating bone tissue and bone substitute biomaterial, and in a short time. Nevertheless, histological analysis remains the best technique for the observation of soft tissue and blood vessels.
35
Choi, Sung-ryul, Ji-won Kwon, Kyung-soo Suk, Hak-sun Kim, Seong-hwan Moon, Si-young Park, and Byung Ho Lee. "The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future." Materials 16, no. 10 (May 10, 2023): 3633. http://dx.doi.org/10.3390/ma16103633.
Full textAbstract:
As the area and range of surgical treatments in the orthopedic field have expanded, the development of biomaterials used for these treatments has also advanced. Biomaterials have osteobiologic properties, including osteogenicity, osteoconduction, and osteoinduction. Natural polymers, synthetic polymers, ceramics, and allograft-based substitutes can all be classified as biomaterials. Metallic implants are first-generation biomaterials that continue to be used and are constantly evolving. Metallic implants can be made from pure metals, such as cobalt, nickel, iron, or titanium, or from alloys, such as stainless steel, cobalt-based alloys, or titanium-based alloys. This review describes the fundamental characteristics of metals and biomaterials used in the orthopedic field and new developments in nanotechnology and 3D-printing technology. This overview discusses the biomaterials that clinicians commonly use. A complementary relationship between doctors and biomaterial scientists is likely to be necessary in the future.
36
Kartashkov, Dmitry. "Components of the Human Body as Objects of Civil Law." Pravovedenie 65, no. 4 (2021): 404–20. http://dx.doi.org/10.21638/spbu25.2021.403.
Full textAbstract:
The article deals with legal problems of the emergence and death of various categories of biomaterials, such as human organs, tissues, and cells, as well as cell lines derived from them. The author shows the main features of the proprietary legal nature of biomaterials from the point of view of the theory of civil law through the prism of the principles of materialism and economic value. The article also examines the emergence of the right to biomaterials according to two models: initial and derivative, which makes it possible to reveal the paradox of the human body as a source of biomaterials. The author shows that the human body is a point of partial coincidence of the object of law and the subject of law, which creates a locus of legal uncertainty. It is proposed to resolve the paradox either using the construction of the “natural environment” of the human body, or through the idea of organic self-ownership. The author makes a reasoned choice in favor of the latter. The article also provides a classification of various biomaterials from the point of view of traditional proprietary characteristics: movability, divisibility, substitutability, etc. The very possibility to talk about biomaterials in this way illustrates in detail their proprietary legal nature. Then the author builds a model of civil relations between the participants in the organ transplant process through the classic triad of the owner’s rights: ownership, usage and disposal. The author, relying on the theory of the transactional nature of informed consent, hypothesizes that the donor has an unnamed property right: the right to destroy the seized biomaterial. Such a right, contrary to the prevailing understanding, does not arise from informed consent as such, but follows the property, since it does not depend on the change in the owner of the biomaterial. The author shows that the totality of the features set out in the article: materiality, the possibility of proprietary legal classification and the presence of derivative property rights following the biomaterial, strengthens the view of biomaterials as objects of property rights.
37
Panebianco, CJ, JH Meyers, J. Gansau, WW Hom, and JC Iatridis. "Balancing biological and biomechanical performance in intervertebral disc repair: a systematic review of injectable cell delivery biomaterials." European Cells and Materials 40 (November 18, 2020): 239–58. http://dx.doi.org/10.22203/ecm.v040a15.
Full textAbstract:
Discogenic back pain is a common condition without approved intervertebral disc (IVD) repair therapies. Cell delivery using injectable biomaterial carriers offers promise to restore disc height and biomechanical function, while providing a functional niche for delivered cells to repair degenerated tissues. This systematic review advances the injectable IVD cell delivery biomaterials field by characterising its current state and identifying themes of promising strategies. Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines were used to screen the literature and 183 manuscripts met the inclusion criteria. Cellular and biomaterial inputs, and biological and biomechanical outcomes were extracted from each study. Most identified studies targeted nucleus pulposus (NP) repair. No consensus exists on cell type or biomaterial carrier, yet most common strategies used mesenchymal stem cell (MSC) delivery with interpenetrating network/co-polymeric (IPN/CoP) biomaterials composed of natural biomaterials. All studies reported biological outcomes with about half the studies reporting biomechanical outcomes. Since the IVD is a load-bearing tissue, studies reporting compressive and shear moduli were analysed and two major themes were found. First, a competitive balance, or ‘seesaw’ effect, between biomechanical and biological performance was observed. Formulations with higher moduli had inferior cellular performance, and vice versa. Second, several low-modulus biomaterials had favourable biological performance and matured throughout culture duration with enhanced extracellular matrix synthesis and biomechanical moduli. Findings identify an opportunity to develop next-generation biomaterials that provide high initial biomechanical competence to stabilise and repair damaged IVDs with a capacity to promote cell function for long-term healing.
38
Rudolf, Rebeka, and Karlo Raić. "Ageing of Advanced Biomaterials." Metallurgical and Materials Data 2, no. 1 (April 2, 2024): 1–5. http://dx.doi.org/10.30544/mmd21.
Full textAbstract:
The paper presents the ageing processes of advanced biomaterials. The medical profession considers ageing as a syndrome of universal, progressive, irreversible processes that take place at the molecular level (DNA, proteins, lipids) and at the organ level. Ageing is treated quite differently by the engineering profession, which considers it as wear, degradation, corrosion and deformation. In the tissue over time, changes in temperature, changes in pH value and the effect of large forces lead to changes in biomaterials, which are known in the literature as biomaterial ageing processes.
39
Pinheiro, Juliana Campos, Braz da Fonseca Neto, Jabes Gennedyr da Cruz Lima, Yunes Araújo Silva, Gabriel Gomes da Silva, Isaac Pessoa Santiago Morais, and Dennys Ramon de Melo Fernandes Almeida. "Use of biomaterials in the surgical regenerative treatment of peri-implantitis: systematic review." Research, Society and Development 10, no. 12 (September 20, 2021): e275101220454. http://dx.doi.org/10.33448/rsd-v10i12.20454.
Full textAbstract:
The aim of this study was to review the scientific literature regarding the effectiveness of different biomaterials in the regenerative treatment of peri-implantitis. A systematic literature search was performed in PubMed/Medline, Web of Science, Science Direct, Embase, and the Cochrane Collaboration Library. Studies on the use of biomaterials in the regenerative treatment of peri-implantitis were selected. The search strategy retrieved 253 articles. After selection, six articles met all inclusion criteria and were included in the present systematic review. The studies showed that an initial therapeutic approach consisting of plaque control and implant surface decontamination and subsequent surgery for biomaterial placement were essential for the successful regenerative treatment of peri-implantitis defects. Analysis of all biomaterials used in surgical regenerative treatment showed that bovine bone grafts provided superior outcomes in terms of new bone formation compared to autogenous grafts and nanocrystalline hydroxyapatite. It is important to note that porous titanium granules have emerged as a promising biomaterial for the regenerative treatment of peri-implantitis. In conclusion, biomaterials are promising for the treatment of peri-implant bone defects and the number of in silico biomaterials that can provide treatment of excellence to patients with this condition is expected to increase in the near future.
40
Sadeghian Dehkord, Ehsan, Greet Kerckhofs, Philippe Compère, France Lambert, and Liesbet Geris. "An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation." Journal of Functional Biomaterials 14, no. 7 (July 22, 2023): 388. http://dx.doi.org/10.3390/jfb14070388.
Full textAbstract:
Facial trauma, bone resection due to cancer, periodontal diseases, and bone atrophy following tooth extraction often leads to alveolar bone defects that require bone regeneration in order to restore dental function. Guided bone regeneration using synthetic biomaterials has been suggested as an alternative approach to autologous bone grafts. The efficiency of bone substitute materials seems to be influenced by their physico-chemical characteristics; however, the debate is still ongoing on what constitutes optimal biomaterial characteristics. The purpose of this study was to develop an empirical model allowing the assessment of the bone regeneration potential of new biomaterials on the basis of their physico-chemical characteristics, potentially giving directions for the design of a new generation of dental biomaterials. A quantitative data set was built composed of physico-chemical characteristics of seven commercially available intra-oral bone biomaterials and their in vivo response. This empirical model allowed the identification of the construct parameters driving optimized bone formation. The presented model provides a better understanding of the influence of driving biomaterial properties in the bone healing process and can be used as a tool to design bone biomaterials with a more controlled and custom-made composition and structure, thereby facilitating and improving the clinical translation.
41
Eslami-Kaliji, Farshid, Niloufar Hedayat Nia, Jonathan R. T. Lakey, Alexandra M. Smink, and Mohammadreza Mohammadi. "Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials." Polymers 15, no. 5 (March 6, 2023): 1313. http://dx.doi.org/10.3390/polym15051313.
Full textAbstract:
Long term function of implantable biomaterials are determined by their integration with the host’s body. Immune reactions against these implants could impair the function and integration of the implants. Some biomaterial-based implants lead to macrophage fusion and the formation of multinucleated giant cells, also known as foreign body giant cells (FBGCs). FBGCs may compromise the biomaterial performance and may lead to implant rejection and adverse events in some cases. Despite their critical role in response to implants, there is a limited understanding of cellular and molecular mechanisms involved in forming FBGCs. Here, we focused on better understanding the steps and mechanisms triggering macrophage fusion and FBGCs formation, specifically in response to biomaterials. These steps included macrophage adhesion to the biomaterial surface, fusion competency, mechanosensing and mechanotransduction-mediated migration, and the final fusion. We also described some of the key biomarkers and biomolecules involved in these steps. Understanding these steps on a molecular level would lead to enhance biomaterials design and improve their function in the context of cell transplantation, tissue engineering, and drug delivery.
42
Cadman, Joseph, Yu Hang Chen, Shi Wei Zhou, and Qing Li. "Creating Biomaterials Inspired by the Microstructure of Cuttlebone." Materials Science Forum 654-656 (June 2010): 2229–32. http://dx.doi.org/10.4028/www.scientific.net/msf.654-656.2229.
Full textAbstract:
The microstructure of cuttlebone is investigated using Scanning Electron Microscopy (SEM). A graded aspect ratio of the base cells between layers is evident in some samples. A method for designing graded biomaterials mimicking this cuttlebone microstructure is developed. Simplified 3D biomaterial samples are created using CAD software. These biomaterials are fabricated using a stereolithographic apparatus (SLA). The homogenisation technique is used to evaluate the mechanical properties of the original cuttlebone sample and the fabricated biomaterial sample. Good agreement is found between the Young’s moduli of corresponding layers. However, it is inconclusive whether the Young’s moduli have a proportional relationship to the aspect ratio of the base cell at this stage of the study.
43
Diviesti, Karla, and Richard C. Holz. "Catalytic Biomaterials for Atrazine Degradation." Catalysts 13, no. 1 (January 7, 2023): 140. http://dx.doi.org/10.3390/catal13010140.
Full textAbstract:
In this paper, triazine hydrolase from Arthrobacter aurescens TC1 (TrzN) was successfully immobilized in alginate beads (TrzN:alginate), alginate beads coated in chitosan (TrzN:chitosan), and tetramethylorthosilicate (TMOS) gels using the sol–gel method (TrzN:sol–gel) for the first time. TrzN:alginate and TrzN:chitosan hydrolyzed 50 µM of atrazine in 6 h with negligible protein loss with an ~80% conversion rate. However, the TrzN:sol–gel biomaterial converted >95% of a 50 µM atrazine solution in an hour with negligible protein loss. The treatment of each of these biomaterials with trypsin confirmed that the catalytic activity was due to the encapsulated enzyme and not surface-bound TrzN. All three of the biomaterials showed potential for long-term storage and reuse, with the only limitation arising from the loss of protein in the storage buffer for the TrzN:alginate and TrzN:chitosan biomaterials, not the denaturation of the encapsulated TrzN. TrzN:sol–gel stood out, with ~100% activity being retained after 10 consecutive reactions. Additionally, the materials stayed active in methanol concentrations <10%, suggesting the ability to increase the solubility of atrazine with organic solvents. The structural integrity of the TrzN:alginate and TrzN:chitosan materials became limiting in extreme pH conditions, while TrzN:sol–gel outperformed WT TrzN. Overall, the TrzN:sol–gel biomaterial proved to be the best atrazine dichlorination biocatalyst. As sol–gels can be cast into any desired shape, including pellets, which can be used in columns, the TrzN:sol–gel biomaterial provides a new avenue for the design of bioremediation methodologies for the removal of atrazine from the environment.
44
Allizond, Valeria, Sara Comini, Anna Maria Cuffini, and Giuliana Banche. "Current Knowledge on Biomaterials for Orthopedic Applications Modified to Reduce Bacterial Adhesive Ability." Antibiotics 11, no. 4 (April 15, 2022): 529. http://dx.doi.org/10.3390/antibiotics11040529.
Full textAbstract:
A significant challenge in orthopedics is the design of biomaterial devices that are able to perform biological functions by substituting or repairing various tissues and controlling bone repair when required. This review presents an overview of the current state of our recent research into biomaterial modifications to reduce bacterial adhesive ability, compared with previous reviews and excellent research papers, but it is not intended to be exhaustive. In particular, we investigated biomaterials for replacement, such as metallic materials (titanium and titanium alloys) and polymers (ultra-high-molecular-weight polyethylene), and biomaterials for regeneration, such as poly(ε-caprolactone) and calcium phosphates as composites. Biomaterials have been designed, developed, and characterized to define surface/bulk features; they have also been subjected to bacterial adhesion assays to verify their potential capability to counteract infections. The addition of metal ions (e.g., silver), natural antimicrobial compounds (e.g., essential oils), or antioxidant agents (e.g., vitamin E) to different biomaterials conferred strong antibacterial properties and anti-adhesive features, improving their capability to counteract prosthetic joint infections and biofilm formation, which are important issues in orthopedic surgery. The complexity of biological materials is still far from being reached by materials science through the development of sophisticated biomaterials. However, close interdisciplinary work by materials scientists, engineers, microbiologists, chemists, physicists, and orthopedic surgeons is indeed necessary to modify the structures of biomaterials in order to achieve implant integration and tissue regeneration while avoiding microbial contamination.
45
Tosiriwatanapong, Terawat, and Weerachai Singhatanadgit. "Zirconia-Based Biomaterials for Hard Tissue Reconstruction." Bone and Tissue Regeneration Insights 9 (January 1, 2018): 1179061X1876788. http://dx.doi.org/10.1177/1179061x18767886.
Full textAbstract:
Implantable biomaterials are increasingly important in the practice of modern medicine, including fixative, replacement, and regeneration therapies, for reconstruction of hard tissues in patients with pathologic osseous and dental conditions. A number of newly developed advanced biomaterials have been introduced as promising candidates for tissue reconstruction. Among these, zirconia-based biomaterials have gained attention as a biomaterial for hard tissue reconstruction due to superior mechanical properties and good chemical and biological compatibilities. This review summarizes the types of zirconia, advantages of zirconia-based biomaterials for hard tissue reconstruction including bone and dental tissues, responses of tissue and cells to zirconia, and surface modifications for enhanced bioactivity of zirconia. Current and future applications of zirconia-based biomaterials for bone and dental reconstruction, ie, medical implanted devices, dental prostheses, and biocompatible osteogenic scaffolds, are also discussed.
46
Ige, Oladeji O., Lasisi E. Umoru, and Sunday Aribo. "Natural Products: A Minefield of Biomaterials." ISRN Materials Science 2012 (May 7, 2012): 1–20. http://dx.doi.org/10.5402/2012/983062.
Full textAbstract:
The development of natural biomaterials is not regarded as a new area of science, but has existed for centuries. The use of natural products as a biomaterial is currently undergoing a renaissance in the biomedical field. The major limitations of natural biomaterials are due to the immunogenic response that can occur following implantation and the lot-to-lot variability in molecular structure associated with animal sourcing. The chemical stability and biocompatibility of natural products in the body greatly accounts for their utilization in recent times. The paper succinctly defines biomaterials in terms of natural products and also that natural products as materials in biomedical fields are considerably versatile and promising. The various types of natural products and forms of biomaterials are highlighted. Three main areas of applications of natural products as materials in medicine are described, namely, wound management products, drug delivery systems, and tissue engineering. This paper presents a brief history of natural products as biomaterials, various types of natural biomaterials, properties, demand and economic importance, and the area of application of natural biomaterials in recent times.
47
Gristina, A. G., G. Giridhar, B. L. Gabriel, P. T. Naylor, and Q. N. Myrvik. "Cell Biology and Molecular Mechanisms in Artificial Device Infections." International Journal of Artificial Organs 16, no. 11 (November 1993): 755–64. http://dx.doi.org/10.1177/039139889301601103.
Full textAbstract:
Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacement and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barrier to the extended use of these devices is bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Adhesion-mediated infections are extremely resistant to antibiotics and host defenses and frequently persist until the biomaterial or foreign body is removed. The pathogenesis of adhesive infections is related, in part, to preferential colonization of “inert” substrata whose surfaces are not integrated with healthy tissues composed of living cells and intact extracellular polymers. Tissue integration is an interesting parallel to microbial adhesion and is a desired phenomenon for the biocompatibility of certain implants and biomaterials. Tissue integration requires a form of eukaryocytic adhesion or compatibility with possible chemical integration to an implant surface. Many of the fundamental principles of interfacial science apply to both microbial adhesion and to tissue integration and are general to and independent of the substratum materials involved. Interactions of biomaterials with bacteria and tissue cells are directed not only by specific receptors and outer membrane molecules on the cell surface, but also by the atomic geometry and electronic state of the biomaterial surface. An understanding of these mechanisms is important to all fields of medicine and is derived from and relevant to studies in microbiology, biochemistry, and physics. Modifications of biomaterial surfaces at an atomic level will allow the programming of cell-to-substratum events, thereby diminishing infection by enhancing tissue compatibility or integration, or by directly inhibiting bacterial adhesion.
48
Al-Maawi, Sarah, James L. Rutkowski, Robert Sader, C. James Kirkpatrick, and Shahram Ghanaati. "The Biomaterial-Induced Cellular Reaction Allows a Novel Classification System Regardless of the Biomaterials Origin." Journal of Oral Implantology 46, no. 3 (February 18, 2020): 190–207. http://dx.doi.org/10.1563/aaid-joi-d-19-00201.
Full textAbstract:
Several different biomaterials are being introduced for clinical applications. However, no current material-specific systematic studies define parameters for evaluating these materials. The aim of this retrospective animal study is to classify biomaterials according to the in vivo induced cellular reaction and outline the clinical consequence of the biomaterial-specific cellular reaction for the regeneration process. A retrospective histologic analysis was performed for 13 polymeric biomaterials and 19 bone substitute materials (BSMs) (of various compositions and origins) that were previously implanted in a standardized subcutaneous model. Semiquantitative analyses were performed at days 3, 15, and 30 after implantation according to a standardized score for the induction of multinucleated giant cells (MNGCs) and vascularization rate. The induced cellular reaction in response to different polymeric materials allowed their classification according to the MNGC score in the following groups: class I induced no MNGCs at any time point, class II induced and maintained a constant number of MNGCs over 30 days, and class III induced MNGCs and provided an increasing number over 30 days. All BSMs induced MNGCs to varying extents. Therefore, the resultant BSM classifications are as follows: class I induced MNGCs with a decreasing number, class II induced and maintained constant MNGCs over 30 days, and class III induced MNGCs with increasing number over 30 days. These observations were mostly related to the biomaterial physicochemical properties and were independent of the biomaterial origin. Consequently, the induction of MNGCs and their increase over 30 days resulted in disintegration of the biomaterial. By contrast, the absence of MNGCs resulted in an integration of the biomaterial within the host tissue. This novel classification provides clinicians a tool to assess the capacity and suitability of biomaterials in the intended clinical indication for bone and soft tissue implantations.
49
Guhathakurta, Soma, and Satish Galla. "Progress in cardiovascular biomaterials." Asian Cardiovascular and Thoracic Annals 27, no. 9 (September 26, 2019): 744–50. http://dx.doi.org/10.1177/0218492319880424.
Full textAbstract:
In 1986, the European Society of Biomaterials Consensus Conference gave a simplified definition of biomaterials as “a non-viable material used in a medical device intended to interact with biological systems”. This seems to be more appropriate when we look into the versatility of applications of biomaterials in the health sector, especially in cardiovascular practice. This field has expanded exponentially in every direction, with multifunctional capability. Heart valves have undergone an evolution in biomaterials and design. Patches and conduits have been developed to correct anatomical deficits, and solutions have been found for narrowing or ballooning of the arteries. Research is ongoing to find replacements for every part of this system by creating replicas made of various materials. To investigate problems pertaining to the cardiovascular system, catheters have undergone an astounding leap in material optimization. In these three sectors, the trends, successes, and failures are worth discussing. This review mainly focuses on the types of biomaterial used for making cardiovascular devices and their advantages and limitations.
50
Wu, Min, Zhihui Lu, Keke Wu, Changwoo Nam, Lin Zhang, and Jinshan Guo. "Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing." Journal of Materials Chemistry B 9, no. 35 (2021): 7063–75. http://dx.doi.org/10.1039/d1tb00847a.
Full textAbstract:
This paper reviews the recent progress in nitric oxide (NO) donors, biomaterial vectors, biomaterial-based NO delivery systems and NO synthetic enzyme mimics, and emphasizes the application potentials of NO releasing biomaterials in chronic wound healing.