Academic literature on the topic 'Biomolecular analyses'

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Journal articles on the topic "Biomolecular analyses"

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Raković, Dejan, Miroljub Dugić, Jasmina Jeknić-Dugić, Milenko Plavšić, Stevo Jaćimovski, and Jovan Šetrajčić. "On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/580491.

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In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by q
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Bates, Kathleen E., and Hang Lu. "Optics-Integrated Microfluidic Platforms for Biomolecular Analyses." Biophysical Journal 110, no. 8 (2016): 1684–97. http://dx.doi.org/10.1016/j.bpj.2016.03.018.

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Gopinath, Subash C. B., and Penmetcha K. R. Kumar. "Biomolecular discrimination analyses by surface plasmon resonance." Analyst 139, no. 11 (2014): 2678. http://dx.doi.org/10.1039/c3an02052e.

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Shinji, Seiichi, Zenya Naito, Toshiyuki Ishiwata, et al. "Pathological and Biomolecular Analyses of Colorectal Endocrine Carcinoma." Journal of Nippon Medical School 74, no. 1 (2007): 87–88. http://dx.doi.org/10.1272/jnms.74.87.

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Perlasca, Paolo, Marco Frasca, Cheick Tidiane Ba, et al. "Multi-resolution visualization and analysis of biomolecular networks through hierarchical community detection and web-based graphical tools." PLOS ONE 15, no. 12 (2020): e0244241. http://dx.doi.org/10.1371/journal.pone.0244241.

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The visual exploration and analysis of biomolecular networks is of paramount importance for identifying hidden and complex interaction patterns among proteins. Although many tools have been proposed for this task, they are mainly focused on the query and visualization of a single protein with its neighborhood. The global exploration of the entire network and the interpretation of its underlying structure still remains difficult, mainly due to the excessively large size of the biomolecular networks. In this paper we propose a novel multi-resolution representation and exploration approach that e
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Etibor, Temitope Akhigbe, Aidan O’Riain, Marta Alenquer, Christian Diwo, Sílvia Vale-Costa, and Maria João Amorim. "Challenges in Imaging Analyses of Biomolecular Condensates in Cells Infected with Influenza A Virus." International Journal of Molecular Sciences 24, no. 20 (2023): 15253. http://dx.doi.org/10.3390/ijms242015253.

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Biomolecular condensates are crucial compartments within cells, relying on their material properties for function. They form and persist through weak, transient interactions, often undetectable by classical biochemical approaches. Hence, microscopy-based techniques have been the most reliable methods to detail the molecular mechanisms controlling their formation, material properties, and alterations, including dissolution or phase transitions due to cellular manipulation and disease, and to search for novel therapeutic strategies targeting biomolecular condensates. However, technical challenge
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Tsumoto, K. "1SE52 Experimental approaches for systematic analyses of biomolecular interactions." Seibutsu Butsuri 45, supplement (2005): S16. http://dx.doi.org/10.2142/biophys.45.s16_1.

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Ranjbar, Bijan, and Pooria Gill. "Circular Dichroism Techniques: Biomolecular and Nanostructural Analyses- A Review." Chemical Biology & Drug Design 74, no. 2 (2009): 101–20. http://dx.doi.org/10.1111/j.1747-0285.2009.00847.x.

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Rudden, Lucas S. P., Samuel C. Musson, Justin L. P. Benesch, and Matteo T. Degiacomi. "Biobox: a toolbox for biomolecular modelling." Bioinformatics 38, no. 4 (2021): 1149–51. http://dx.doi.org/10.1093/bioinformatics/btab785.

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Abstract Motivation The implementation of biomolecular modelling methods and analyses can be cumbersome, often carried out with in-house software reimplementing common tasks, and requiring the integration of diverse software libraries. Results We present Biobox, a Python-based toolbox facilitating the implementation of biomolecular modelling methods. Availability and implementation Biobox is freely available on https://github.com/degiacom/biobox, along with its API and interactive Jupyter notebook tutorials.
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Rembe, Julian-Dario, Waseem Garabet, Jan-Wilm Lackmann, et al. "Assessment and Monitoring of the Wound Micro-Environment in Chronic Wounds Using Standardized Wound Swabbing for Individualized Diagnostics and Targeted Interventions." Biomedicines 12, no. 10 (2024): 2187. http://dx.doi.org/10.3390/biomedicines12102187.

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Background/Objectives: Patient-specific diagnostic and therapeutic approaches are important in the care of people with chronic wounds. The heterogeneity of underlying disease profiles and the diversity of the wound micro-environment make generalized approaches difficult. While high-throughput molecular diagnostic methods are increasingly widespread and available, the analysis of objective biomolecular disease patterns has not found its way into everyday wound management. The aim of this study is to evaluate the use of wound swab samples for the analysis of biomarkers and disease patterns in pe
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Dissertations / Theses on the topic "Biomolecular analyses"

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Göransson, Jenny. "Readout Strategies for Biomolecular Analyses." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9343.

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This thesis describes three readout formats for molecular analyses. A common feature in all works is probing techniques that upon specific target recognition ideally results in equimolar amounts of DNA circles. These are then specifically amplified and detected using any of the techniques presented herein. The first paper presents a method that enables homogeneous digital detection and enumeration of biomolecules, represented as fluorescence-labelled DNA macromolecules. This method offers precise measurements to be performed with a wide linear dynamic range. As an application, two closely rela
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Göransson, Jenny. "Readout Strategies for Biomolecular Analyses /." Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9343.

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Lin, Xiu-Mei [Verfasser], Volker [Akademischer Betreuer] Deckert, and Wolfgang [Akademischer Betreuer] Weigand. "Tip-enhanced Raman Spectroscopy (TERS) for Biomolecular Analyses at Nanometer / Xiu-Mei Lin. Gutachter: Volker Deckert ; Wolfgang Weigand." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1047579073/34.

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Lin, Xiu-Mei [Verfasser], Volker Akademischer Betreuer] Deckert, and Wolfgang [Akademischer Betreuer] [Weigand. "Tip-enhanced Raman Spectroscopy (TERS) for Biomolecular Analyses at Nanometer / Xiu-Mei Lin. Gutachter: Volker Deckert ; Wolfgang Weigand." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://nbn-resolving.de/urn:nbn:de:gbv:27-20140210-112607-2.

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Navarrete, Belda Vanessa. "Domesticación animal y primeras prácticas ganaderas en el noreste peninsular (5500-4500 cal BC). Integración de los análisis bioquímicos en arqueozoología." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/461194.

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En el presente trabajo de tesis doctoral se aborda la problemática de la dinámica del proceso de domesticación animal y las prácticas ganaderas iniciales en el extremo más occidental del área mediterránea a lo largo del intervalo temporal que abarca entre el 5.500-4.700 cal ANE. El objetivo principal de la tesis se aborda a partir del estudio de una muestra significativa de yacimientos neolíticos situados en el noreste de la Península Ibérica. Se ha evaluado con esta tesis doctoral los principales modelos explicativos planteados en torno a los orígenes del neolítico en la Península Ibérica,
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Zhang, Yingbo. "Microfluidic methods for biomolecular analysis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274931.

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Microfluidics is the science and technology of manipulating fluids at small scales ranging from microlitres (10$^{-6}$) to picolitres (10$^{-12}$). The fundamental physics is distinct from fluid behaviour on bulk scales and laminar flow is the key characteristic on this scale. Microfluidic systems have a wide range of applications in many disciplines from engineering to physics, chemistry and biotechnology. In this thesis, I explore different strategies exploiting the capabilities of microfluidic devices for manipulating and analysing biomolecules. A particular focus of the work is on the stud
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Tiwari, Purushottam Babu. "Multimode Analysis of Nanoscale Biomolecular Interactions." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1923.

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Biomolecular interactions, including protein-protein, protein-DNA, and protein-ligand interactions, are of special importance in all biological systems. These interactions may occer during the loading of biomolecules to interfaces, the translocation of biomolecules through transmembrane protein pores, and the movement of biomolecules in a crowded intracellular environment. The molecular interaction of a protein with its binding partners is crucial in fundamental biological processes such as electron transfer, intracellular signal transmission and regulation, neuroprotective mechanisms, and reg
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Heucke, Stephan F. "Advancing nanophotonic devices for biomolecular analysis." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-165294.

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Malleo, Daniele. "Impedance spectroscopy for cellular and biomolecular analysis." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/66388/.

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The application of microfabrication technology to molecular and cell biology has motivated the rapid development of a novel class of microdevices collectively known as ‘Lab On a Chip’ devices. Impedance spectroscopy is a non-invasive, label-free, analytical technique that is amenable to miniaturization, electronic integration, automation, and scalability within ‘LOC’ devices. This thesis describes a microfabricated device for performing continuous impedance analysis of individual cells held in an array of hydrodynamic traps. This device enables continuous long-term analysis of cells and time-d
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Ezzeddine, Bilal. "Instrumentation for multilinear analysis of biomolecular fluorescence /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487671640054913.

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Books on the topic "Biomolecular analyses"

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Hagen, Wilfred Raymond. Biomolecular EPR spectroscopy. Taylor & Francis, 2008.

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Maber, Jon. Data analysis for biomolecular sciences. Longman, 1999.

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M, Caprioli R., Malorni Antonio, and Sindona Giovanni, eds. Mass spectrometry in biomolecular sciences. Kluwer Academic, 1996.

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Koeppl, Heinz, Gianluca Setti, Mario di Bernardo, and Douglas Densmore, eds. Design and Analysis of Biomolecular Circuits. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6766-4.

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Nagata, Kazuhiro, and Hiroshi Handa, eds. Real-Time Analysis of Biomolecular Interactions. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-66970-8.

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Kessler, Christoph, ed. Nonradioactive Analysis of Biomolecules. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57206-7.

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H, Mantsch Henry, and Chapman Dennis 1927-, eds. Infrared spectroscopy of biomolecules. Wiley-Liss, 1996.

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Ham, Bryan M. Even electron mass spectrometry with biomolecular applications. Wiley, 2008.

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Santra, Tuhin Subhra, and Fan-Gang Tseng. Single Biomolecule Detection and Analysis. CRC Press, 2023. http://dx.doi.org/10.1201/9781003409472.

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Read, Randy. Advancing Methods for Biomolecular Crystallography. Springer Netherlands, 2013.

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Book chapters on the topic "Biomolecular analyses"

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Evershed, Richard P., and Katherine A. Clark. "Trends in Use of Organic Balms in Egyptian Mummification Revealed Through Biomolecular Analyses." In The Handbook of Mummy Studies. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-3354-9_9.

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Evershed, Richard P., and Katherine A. Clark. "Trends in Use of Organic Balms in Egyptian Mummification Revealed Through Biomolecular Analyses." In The Handbook of Mummy Studies. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1614-6_9-1.

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Quack, Salina, and David Dulin. "Surface Functionalization, Nucleic Acid Tether Characterization, and Force Calibration for a Magnetic Tweezers Assay." In Single Molecule Analysis. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3377-9_19.

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AbstractMagnetic tweezers are a force spectroscopy single-molecule technique. They enable the mechanical manipulation of biomolecules via the means of a magnetic particle under an attractive force applied by a magnetic field source. The magnetic particle is tethered to the glass surface of a flow chamber by the biomolecule, and functionalization strategies have been developed to reduce the nonspecific interactions of either the magnetic particles or biomolecules with the surface. Here, we describe two complementary strategies to achieve a high tether density while reducing the interactions of
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Bagshaw, Clive R. "Data Analysis." In Biomolecular Kinetics. CRC Press, 2017. http://dx.doi.org/10.1201/9781315120355-8.

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Dulin, David. "An Introduction to Magnetic Tweezers." In Single Molecule Analysis. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3377-9_18.

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AbstractMagnetic tweezers are a single-molecule force and torque spectroscopy technique that enable the mechanical interrogation in vitro of biomolecules, such as nucleic acids and proteins. They use a magnetic field originating from either permanent magnets or electromagnets to attract a magnetic particle, thus stretching the tethering biomolecule. They nicely complement other force spectroscopy techniques such as optical tweezers and atomic force microscopy (AFM) as they operate as a very stable force clamp, enabling long-duration experiments over a very broad range of forces spanning from 1
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Pattini, Linda, and Sergio Cerutti. "Biomolecular Sequence Analysis." In Advanced Methods of Biomedical Signal Processing. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118007747.ch20.

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Akbar Hussain, Erum, Zubi Sadiq, and Muhammad Zia-Ul-Haq. "Analysis of Betalains." In Betalains: Biomolecular Aspects. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95624-4_8.

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Puchkov, E. O. "Determining the Location and Movement of Biomolecules and Biomolecular Complexes in Single Microbial Cells." In Single Biomolecule Detection and Analysis. CRC Press, 2023. http://dx.doi.org/10.1201/9781003409472-7.

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Natarajan, Vijay, Patrice Koehl, Yusu Wang, and Bernd Hamann. "Visual Analysis of Biomolecular Surfaces." In Mathematics and Visualization. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-72630-2_14.

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Markey, Francis, and Franz Schindler. "Biomolecular-Interaction Analysis (BIA-Technology)." In Modern Optics, Electronics and High Precision Techniques in Cell Biology. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80370-3_9.

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Conference papers on the topic "Biomolecular analyses"

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Sharma, G., M. Badescu, A. Dubey, et al. "Kinematics and Workspace Analysis of Protein Based Nano-Motors." In ASME 2004 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/detc2004-57569.

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Kinematic and workspace analyses are performed to predict the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH environment. The conformational change produces a motion of about 10 nm, making the VPL a basic linear actuator, which can be further interfaced with other organic/inorganic nanoscale components such as DNA actuators and carbon nanotubes. This paper presents the principle of operation of the VPL motor and the development
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Murray, Kermit K., Michelle D. Beeson, and David H. Russell. "Laser Ionization of Biomolecules in Solution." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1994. http://dx.doi.org/10.1364/laca.1994.tha.5.

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Many powerful laser based methods are unavailable for the analysis of molecules in solution. Techniques for the analysis of liquids are particularly important for the study of biomolecules, whose natural environment is a water solution. Mass spectrometry is a powerful analytical technique, but liquids and mass spectrometers are fundamentally incompatible. We have developed a technique for laser ionization of biomolecules in solution by applying matrix-assisted laser desorption ionization (MALDI) to liquid aerosols. In the typical MALDI experiment, the analyte biomolecule is deposited from solu
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Lee, Donghee, Jeonghoon Lee, Choonho Park, and Jung Kyung Kim. "Simultaneous Measurements of Diffusion Coefficient on Cell Membrane by Fluorescence Photobleaching and Single Quantum Dot Tracking Techniques." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13027.

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The diffusion of biomolecules in plasma membranes is the key mechanism of their transportation. Lipid rafts, which are diffused on a plasma membrane, carry receptors and proteins. Receptors become the passages where viruses invade, and proteins play an important role in signaling and controlling functions of cells. If we know the characteristics of biomolecular motility and structural differences between normal cells and diseased cells, we could find out how to treat the disease. So, it is very important to develop the method which analyzes the dynamic biomolecular movement in the cell membran
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Merlo, Manuele, Fabio Negretto, and Franco Maria Montevecchi. "The Effect of the Electrostatic Field on the Deflection of Microcantilever Biosensors." In ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95155.

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Microcantilever biosensors offer the capability to detect specific molecular binding like complementary DNA fragment hybridization or specific antibody-antigen binding. The cantilever deflection, which can be optically detected, is caused by the adsorption of biological molecules like DNA fragments upon the microcantilever surface and the subsequent specific binding to the complementary species. The cantilever deflection is due to the surface stress induced by the free energy variation on the cantilever surface. Contributions to the free energy variation come from a number of interactions with
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Pan, Ming-Yang, Kuang-Li Lee, Likang Wang, and Pei-Kuen Wei. "Improving detection limit of surface plasmon resonance biosensor using digital method." In JSAP-OSA Joint Symposia. Optica Publishing Group, 2017. http://dx.doi.org/10.1364/jsap.2017.5p_a409_3.

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Surface plasmon resonance (SPR) sensor has been widely used in detection of biomolecular interaction due to its advantages of label-free and high sensitivity. The ligand-modified sensor surface specifically captures the analyte which results in a small increase of the refractive index (RI) that can be measured from the change in the optical response, such as intensity and wavelength. However, in real application of ultralow concentration, the distribution of caperaturing biomolecules on the sensing surface is usually nonuniform. The corresponding signals are averaged by whole detection area th
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Waghmare, Prashant R., and Sushanta K. Mitra. "Mechanism of Cell Transport in a Microchannel With Binding Between Cell Surface and Immobilized Biomolecules." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12691.

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Recent trends in micro and nano fabrication techniques have opened a new era for microfluidic based immunosensing devices. In immunosensing microfluidic device, the buffer solution transports the different biomolecules and cells. The interaction between the cell and surface of the microchannel takes place during this transport. In the present study, the effect of interaction between the cell and the immobilized biomolecule on the cell transport is analyzed theoretically. A single cell transport is studied with the interaction between the cell surface and the microchannel wall. The type of immo
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Yue, Min, Daniel E. Dedrick, Henry Lin, Srinath Satyanarayana, and Arunava Majumdar. "Microcantilever Arrays for Multiplexed Biomolecular Analysis." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32807.

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An accurate, efficient, and quantitative method for detection of multiple biomolecules, such as DNA and proteins, would benefit many bio-medical applications. These applications include diagnostics of complex diseases such as cancer, drug discovery, and development of fundamental scientific knowledge regarding signaling pathways. We have developed a chip-level microcantilever array designed for high-throughput biomolecular analysis. In particular, biological reactions on one surface of a microcantilever beam change its surface tension due to intermolecular energetic and entropic interactions.
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Karnik, Rohit, Chuanhua Duan, Kenneth Castelino, Rong Fan, Peidong Yang, and Arun Majumdar. "Transport of Ions and Molecules in Nanofluidic Devices." In ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62065.

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Interesting transport phenomena arise when fluids are confined to nanoscale dimensions in the range of 1–100 nm. We examine three distinct effects that influence ionic and molecular transport as the size of fluidic channels is decreased to the nanoscale. First, the length scale of electrostatic interactions in aqueous solutions becomes comparable to nanochannel size and the number of surface charges becomes comparable to the number of ions in the channel. Second, the size of the channel becomes comparable to the size of biomolecules such as proteins and DNA. Third, large surface area-to-volume
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Nguyen, Thai Huu, and Qiao Lin. "An Aptamer-Functionalized Microfluidic Platform for Biomolecular Purification and Sensing." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82142.

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Aptamers are oligonucleotides (DNA or RNA) that bind to chemical and biological analyte targets via affinity interactions. Through an in vitro synthetic process, aptamers can be developed for an extremely broad spectrum of analytes, such as small molecules, proteins, cells, viruses, and bacteria. Target recognition by aptamers is highly selective, as affinity interactions result in secondary aptamer conformational structures that specifically fit the target. The aptamer-target binding is also reversible and depends strongly on external stimuli such as pH and temperature. The specificity and st
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Waldherr, Steffen. "Robustness analysis of biomolecular networks." In 2014 European Control Conference (ECC). IEEE, 2014. http://dx.doi.org/10.1109/ecc.2014.6862637.

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Reports on the topic "Biomolecular analyses"

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López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez, and Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules: A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.

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Review question / Objective: Does the bioactive surface of titanium dental implants, based on biomolecules, influence osseointegration?. The aim of our study was to evaluate the role and efficacy of bioactive surfaces in osseointegration. Our review study limited the research interest to titanium dental implants coated with a biomolecule, i.e., an organic molecule produced by a living organism. Condition being studied: In recent years, much attention has been paid to topographical modifications of dental implant surfaces, as well as to their coating with biologically active substances.a bioact
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Chailapakul, Orawon. Novelty in Analytical Chemistry for Innovation of Detection. Chulalongkorn University, 2017. https://doi.org/10.58837/chula.res.2017.19.

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Analytical chemistry is the one of the most importance not only to all branches of chemistry but also to all the biological sciences, to engineering, and, more recently, medicine, public health, food, environment and the supply of energy in all forms. Therefore, the developments of novel detection methods play an important role to obtain both qualitative analysis and quantification of the chemical or biomolecule components of natural and artificial materials. This work has been separated into 3 groups for finishing the novelty in detection methods. First, novel nanomaterials-based or nanocompo
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Beebe, David J. An Advanced Platform for Biomolecular Detection and Analysis Systems. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada432950.

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Rodriguez Muxica, Natalia. Open configuration options Bioinformatics for Researchers in Life Sciences: Tools and Learning Resources. Inter-American Development Bank, 2022. http://dx.doi.org/10.18235/0003982.

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The COVID-19 pandemic has shown that bioinformatics--a multidisciplinary field that combines biological knowledge with computer programming concerned with the acquisition, storage, analysis, and dissemination of biological data--has a fundamental role in scientific research strategies in all disciplines involved in fighting the virus and its variants. It aids in sequencing and annotating genomes and their observed mutations; analyzing gene and protein expression; simulation and modeling of DNA, RNA, proteins and biomolecular interactions; and mining of biological literature, among many other c
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