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Relevant bibliographies by topics / Bioorganic synthesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Bioorganic synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Dong, Hai. "Efficient Carbohydrate Synthesis By Intra- and Supramolecular Control." Doctoral thesis, Stockholm : Kemivetenskap, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9882.

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2

Carnell, Andrew John. "Cycloalkanone monooxygenase enzymes in organic synthesis." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293971.

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3

Kaptan, Yelda. "Utilization Of Scytalidium Thermophilum Phenol Oxidase In Bioorganic Synthesis." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605353/index.pdf.

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ABSTRACT UTILIZATION OF SCYTALIDIUM THERMOPHILUM PHENOL OXIDASE IN BIOORGANIC SYNTHESES Kaptan, Yelda M.S., Department of Biotechnology Supervisor: Prof. Dr. Z&uuml<br>mr&uuml<br>t B. &Ouml<br>gel Co-supervisor: Prof Dr. Ufuk Bakir September 2004, 90 pages In this study, the ultimate aim was to utilize phenol oxidases of Scytalidium thermophilum in bioorganic syntheses. For this purpose, studies were conducted towards enhancing the production of phenol oxidases by Scytalidium thermophilum, developing a suitable method for laccase activity assays, analyzing the effects of organic so

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4

Pradeepkumar, Pushpangadan Indira. "Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4247.

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5

Lam, Polo Chun Hung. "Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/40013.

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Cationâ Ï interaction is an important determinant in protein structure and function. Among the three proteinogenic aromatic amino acids, tryptophan (Trp) is the strongest cationâ Ï donor. We reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached at different position of the indole moiety. These new tryptophan regioisomers can effect a different mode of cationâ Ï interaction. In nature, dramatic increases in binding affinity can be achieved through multivalent binding. Following a fragmentation-dimerization approach, we synthesized

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6

Johansson, Susanne. "Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses." Doctoral thesis, Umeå universitet, Kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1641.

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The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. This thesis describes studies towards antiviral agents targeting adenovirus type 37 (Ad37), which causes the severe ocular infection epidemic keratoconjunctivitis (EKC). Cell surface oligosaccharides serve as cellular receptors for many pathogens, including

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7

Dahlgren, Markus. "Statistical molecular design, QSAR modeling, and scaffold hopping development of type III secretion inhibitors in Gram negative bacteria /." Doctoral thesis, Umeå : Department of Chemistry, Umeå Univ, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32506.

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8

Hussain, Shahed. "The development of novel biocatalytic routes for the synthesis of enantiomerically-pure chiral amines." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-development-of-novel-biocatalytic-routes-for-the-synthesis-of-enantiomericallypure-chiral-amines(eba89b88-6801-40cc-a3c3-9c5f1c518d0f).html.

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Chiral amines represent a pervasive structural motif found in various natural products, pharmaceuticals, agrochemicals and fine chemicals. Their preparation in single-enantiomer form continues to attract significant research attention and although many advances have been made in the area of synthetic organic chemistry to increase the scope of the routes to these moieties, there remains an ever-growing need of general strategies for the assembly of structurally-diverse amines which also conform to the efficiency and environmental requirements of modern manufacturing processes. This report inves

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9

Honcharenko, Dmytro. "Conformationally Constrained Nucleosides, Nucleotides and Oligonucleotides : Design, Synthesis and Properties." Doctoral thesis, Uppsala universitet, Bioorganisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8887.

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This thesis is based on six original research publications describing synthesis, structure and physicochemical and biochemical analysis of chemically modified oligonucleotides (ONs) in terms of their potential diagnostic and therapeutic applications. Synthesis of two types of bicyclic conformationally constrained nucleosides, North-East locked 1',2'-azetidine and North locked 2',4'-aza-ENA, is described. Study of the molecular structures and dynamics of bicyclic nucleosides showed that depending upon the type of fused system they fall into two distinct categories with their respective internal

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10

Vongvilai, Pornrapee. "Dynamic Covalent Resolution: Applications in System Screening and Asymmetric Synthesis." Doctoral thesis, Stockholm : Skolan för kemivetenskap, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11200.

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11

Trant, John F. "Importance of the Structural Components of C-linked Glycopeptides to Specific-antifreeze Activity: From Glycopeptides to Small Molecule Inhibitors of Ice Recrystallization." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20710.

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One of the largest problems in current medicine is the shortage of organs for transplant due to technological limitations in the storage of organs for any length of time. A possible solution to this problem would involve cryopreservation. However, current cryopreservatives such as sucrose or DMSO have concerning cytotoxic issues that limit their possible applications. A major cause of cryoinjury is the uncontrolled recrystallization of inter and intra-cellular ice crystals that occurs during the thawing process leading to mechanical damage and dehydration. The Ben lab has thus been interested

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12

Chorell, Erik. "Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37161.

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New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. Pilicides are a class of compounds based on a ring-fused 2-pyridone scaffold that target bacterial virulence by blocking the chaperone/usher pathway in E. coli and thereby inhibit the assembly of pili. This thesis describes the design, synthesis, and biological evaluation of compounds based on the pilicide scaffold with the

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13

Spjut, Sara. "Glycoconjugates synthesis and investigation of carbohydrate-protein interactions /." Doctoral thesis, Umeå : Kemiska institutionen, Umeå universitet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33841.

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14

Liu, Gu. "Target identification and validation studies in chemical biology & Synthesis of medium-sized ring containing compounds via oxidative fragmentation." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/986.

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Part I of this thesis describes the development of bioactive small molecules of relevance to the study of the apicomlexan parasite Toxoplasma gondii into useful chemical tools. The research includes the target identification and validation studies, using both chemical and biological methods. Chapter 1 provides an overview of chemical genetics with a particular emphasis on methods for the identification of the protein targets of bioactive small molecules. The concept of biochemical protein target identification techniques was introduced with a detailed discussion of interesting applications fro

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15

Mmelesi, Olga Kelebogile. "Synthesis and characterization of pine cone carbon supported iron oxide catalyst for dye and phenol degradation." Thesis, Vaal University of Technology, 2017. http://hdl.handle.net/10352/418.

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M. Tech. (Department of Chemical Engineering, Faculty of Engineering and Technology), Vaal University of Technology<br>Fenton oxidation is classified into two processes, homogeneous and heterogeneous. Homogeneous Fenton oxidation process, have been shown to be efficient in the degradation of organic pollutants. However, it was shown to have limitations which can be addressed by the heterogeneous Fenton oxidation. Despite the high efficiency of the heterogeneous Fenton oxidation process in the degradation of recalcitrant organic pollutants, the currents synthesis trends of the heterogeneous Fen

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16

Gullfot, Fredrika. "Synthesis of xyloglucan oligo- and polysaccharides with glycosynthase technology." Licentiate thesis, KTH, School of Biotechnology (BIO), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-10178.

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<p>Xyloglucans are polysaccharides found as storage polymers in seeds and tubers, and as cross-linking glycans in the cell wall of plants. Their structure is complex with intricate branching patterns, which contribute to the physical properties of the polysaccharide including its binding to and interaction with other glycans such as cellulose.</p><p>Xyloglucan is widely used in bulk quantities in the food, textile and paper making industries. With an increasing interest in technically more advanced applications of xyloglucan, such as novel biocomposites, there is a need to understand and contr

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17

Nygren, Patrik. "Bioorganisk fastfas syntes för att skapa intelligenta ytor." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2272.

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<p>This thesis investigates three different surface modifications, and the route to design and synthesize them. The thesis is therefore divided into three sub- projects. (i.) Design and synthesis of a peptide which secondary structure could be controlled by a negatively charged surface. (ii.) Design and synthesis of a cyclic peptide, that would self-organize prior to surface interaction, using the type I anti-freeze protein of a winter flounder as template. (iii.) The use of solid-phase synthesis to make the synthesis of SAM-molecules easier.</p>

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18

Rettig, Hartmut Arnim. "Methoden zur Synthese von definierten bioorganisch-synthetischen Blockcopolymeren." Phd thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982242581.

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19

Angelin, Marcus. "Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications." Doctoral thesis, KTH, Organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12524.

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This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis. Part one offers a general introduction, as well as a more detailed description of DCC, being the central concept of this thesis. Part two explores the potential of the nitroaldol reaction as a tool for constructing dynamic systems, employing benzaldehyde derivatives and nitroalkanes. This reaction is then applied in part three where a dynamic nitroaldol system is resolved

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20

Wazeerud-Din, Idris. "Synthetic Approaches towards Novel Isoform Selective PI3K Inhibitors and Their Biological Activities against Prostate Cancer Cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2018. http://digitalcommons.auctr.edu/cauetds/143.

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The development of novel imidazopyridines, which includes both tetrahydroimidazo[1,5-a]pyridine (rIMP) and imidazo[1,5-a]pyridine (IMP) was investigated using conventional and microwave induced procedures that afforded compounds at high yield of 88-96%. rIMP was synthesized using a two-step procedure that involved the microwave synthesis of IMP, then the reduction of the pyridine moiety of the fused imidazopyridine rings using 10% Pd/C and hydrazine monohydrate. The microwave synthesis of imidazopyridines involved the one pot reaction of 2-benzoylpyridine, substituted benzaldehyde and ammonium

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21

Tung, Yu-Wen, and 童郁雯. "Synthesis and Bioorganic Studies on Symplectoteuthis Bioluminescence." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/12278088521912818994.

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碩士<br>國立清華大學<br>化學系<br>100<br>A luminous squid, Symplectoteuthis oualaniensis, emits blue light, and its photoprotein has been named as symplectin. The luminous substrate of symplectin is dehydrocoelenterazine (DCL) as natural chromophore. A synthetic chromophore, 2,4-difluoro-dehydrocoelenterazine (2,4-diF-DCL), was found to emits 2 times bioluminescence light amount comparing to natural form chromophore (DCL). The exchange of chromophore between 2,4-diF-DCL and DCL in symplectin might happen during incubation at pH 6. To prove the exchange of the chromophores, several diF-DCL analogs with mo

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22

Paschal, Beth Martell 1975. "Bioorganic and biochemical studies of cyclopropane fatty acid synthase from Escherichia coli." 2003. http://hdl.handle.net/2152/12549.

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23

Tupec, Michal. "Chemoenzymová synthesa antivirálních profarmak." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-347803.

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Lipases have been widely applied in the manufacture of food products and in some areas of the industry, nowadays they are used in synthetic organic chemistry catalyzing the hydrolytic/esterification reactions under very mild conditions in the field of protecting groups or enantiomer resolution. In this study, the commercial lipase from bacterium Pseudomonas fluorescens was immobilized using the sol-gel process into organosilicate materials with propyl, octyl or phenyl substituents. The highest hydrolytic activity was found in the enzyme on the octyl-derived carrier. The immobilized enzymes dif

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24

Kupeta, Albert Jerry Kafushe. "Synthesis of cross-linked pine cone biosorbent and its applications in industrial wastewater treatment." Thesis, 2014. http://hdl.handle.net/10352/340.

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M. Tech. (Department of Chemistry, Faculty of Applied and Computer Sciences) -- Vaal University of Technology<br>The widespread use of phenols and phenolic derivatives in industrial applications has resulted in their discharge as part of industrial wastewater. These chemicals are toxic and need to be removed from the aqueous environment. Amongst the available pollutant removal technologies, adsorption has been widely used due to its simplicity, ease of operation, cost-effectiveness and ability to sequester pollutants at very low concentrations. Different adsorbents have been applied for remova

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25

Vijayalakshmi, N. "Functional Dendritic Structures From Bile Acids : Supramolecular Hosts, Light Harvesters And Drug Carriers." Thesis, 2006. http://hdl.handle.net/2005/552.

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Functional Dendritic Structures from Bile Acids: Supramolelcular Hosts, Light Harvesters and Drug Carriers Chapter 1. An Overview of Functional Dendrimers. Dendrimers are welldefined, hyperbranched macromolecules that are prepared by highly controlled iterative methodologies. The ability to modulate the size, molecular weight, chemical functionalities and the position and number of functional groups in dendrimers make them promising candidates for a wide variety of applications. In this chapter, three areas 1) hostguest chemistry 2) light harvesting and 3) drug delivery, where dendrimers are

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26

Rettig, Hartmut Arnim [Verfasser]. "Methoden zur Synthese von definierten bioorganisch-synthetischen Blockcopolymeren / von Hartmut Arnim Rettig." 2006. http://d-nb.info/982242581/34.

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